Structural position:

  • Domain Type: Fn3
  • Aligned Position: 103
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand F

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
E/G 15727 Fn3-1 71 rs1342638829 0.3032 -1.278 0.959 N 0.533 0.264 0.371157983038 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/G 15727 Fn3-1 71 rs1342638829 0.3032 -1.278 0.959 N 0.533 0.264 0.371157983038 gnomAD-4.0.0 1.59328E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43332E-05 0
E/D 15828 Fn3-2 71 None 0.2407 None 0.999 N 0.473 0.311 0.251639045875 gnomAD-4.0.0 1.59358E-06 None None None None N None 0 0 None 0 2.77948E-05 None 0 0 0 0 0
E/G 15828 Fn3-2 71 None 0.406 None 1.0 D 0.705 0.571 0.572690963233 gnomAD-4.0.0 2.73854E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59978E-06 0 0
E/K 15828 Fn3-2 71 rs1246983682 0.5491 None 0.999 N 0.529 0.369 0.406806705197 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 1.01626E-03 None 0 0 None 0 0 0 0 0
K/E 15929 Fn3-3 71 rs1386533299 0.1743 0.144 0.062 N 0.46 0.157 0.208816687407 gnomAD-2.1.1 6.04E-06 None None None None N None 0 0 None 0 0 None 4.79E-05 None 0 0 0
K/E 15929 Fn3-3 71 rs1386533299 0.1743 0.144 0.062 N 0.46 0.157 0.208816687407 gnomAD-4.0.0 1.22659E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.14977E-04 0
E/K 16124 Fn3-4 70 rs754392831 0.4351 -0.903 0.999 N 0.584 0.389 0.450441870249 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.68407E-04 None 0 None 0 0 0
W/R 16224 Fn3-5 70 rs148549746 0.9555 -0.819 1.0 N 0.812 0.521 0.578586219528 gnomAD-2.1.1 4.69E-05 None None None None N None 0 0 None 0 0 None 0 None 4.22E-05 8.67E-05 1.50286E-04
W/R 16224 Fn3-5 70 rs148549746 0.9555 -0.819 1.0 N 0.812 0.521 0.578586219528 gnomAD-3.1.2 5.27E-05 None None None None N None 2.42E-05 0 0 0 0 None 9.43E-05 0 8.83E-05 0 0
W/R 16224 Fn3-5 70 rs148549746 0.9555 -0.819 1.0 N 0.812 0.521 0.578586219528 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
W/R 16224 Fn3-5 70 rs148549746 0.9555 -0.819 1.0 N 0.812 0.521 0.578586219528 gnomAD-4.0.0 6.70232E-05 None None None None N None 1.33758E-05 0 None 0 0 None 9.51807E-05 0 8.20081E-05 0 6.46831E-05
E/D 16420 Fn3-6 70 rs2056859473 0.2803 None 0.999 N 0.472 0.289 0.229264304666 gnomAD-3.1.2 6.59E-06 None None None None N None 0 6.57E-05 0 0 0 None 0 0 0 0 0
E/D 16420 Fn3-6 70 rs2056859473 0.2803 None 0.999 N 0.472 0.289 0.229264304666 gnomAD-4.0.0 6.58857E-06 None None None None N None 0 6.57117E-05 None 0 0 None 0 0 0 0 0
E/G 16420 Fn3-6 70 rs1402412207 0.4376 -1.606 1.0 D 0.763 0.474 0.518585293439 gnomAD-2.1.1 4.04E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
E/G 16420 Fn3-6 70 rs1402412207 0.4376 -1.606 1.0 D 0.763 0.474 0.518585293439 gnomAD-4.0.0 1.59393E-06 None None None None N None 5.67408E-05 0 None 0 0 None 0 0 0 0 0
E/K 16420 Fn3-6 70 rs764682084 0.3713 -0.537 0.999 N 0.613 0.403 0.447609009685 gnomAD-2.1.1 2.02E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 3.57E-05 0
E/K 16420 Fn3-6 70 rs764682084 0.3713 -0.537 0.999 N 0.613 0.403 0.447609009685 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/K 16420 Fn3-6 70 rs764682084 0.3713 -0.537 0.999 N 0.613 0.403 0.447609009685 gnomAD-4.0.0 6.20235E-06 None None None None N None 0 0 None 0 0 None 0 0 7.63203E-06 1.09835E-05 0
K/N 16520 Fn3-7 71 rs779658426 0.8202 -1.194 1.0 N 0.724 0.254 0.187945064343 gnomAD-2.1.1 5.69E-05 None None None None N None 0 4.10654E-04 None 0 0 None 0 None 0 0 0
K/N 16520 Fn3-7 71 rs779658426 0.8202 -1.194 1.0 N 0.724 0.254 0.187945064343 gnomAD-4.0.0 2.26238E-05 None None None None N None 0 3.14861E-04 None 0 0 None 0 0 1.53058E-05 0 3.32127E-05
E/D 16620 Fn3-8 70 None 0.4867 None 0.434 N 0.208 0.128 0.246773566709 gnomAD-4.0.0 1.59388E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86208E-06 0 0
E/K 16620 Fn3-8 70 None 0.5018 None 0.998 N 0.551 0.413 0.348983352498 gnomAD-4.0.0 4.10813E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49923E-06 1.15977E-05 0
E/V 16620 Fn3-8 70 None 0.3942 None 1.0 N 0.789 0.524 0.506006782367 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
E/G 16821 Fn3-10 71 rs781091773 0.6083 -1.592 0.477 D 0.633 0.31 0.380730819819 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
E/G 16821 Fn3-10 71 rs781091773 0.6083 -1.592 0.477 D 0.633 0.31 0.380730819819 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 16821 Fn3-10 71 rs781091773 0.6083 -1.592 0.477 D 0.633 0.31 0.380730819819 gnomAD-4.0.0 1.36402E-05 None None None None N None 0 0 None 0 0 None 0 0 1.86551E-05 0 0
E/A 16923 Fn3-11 72 None 0.1686 None 0.999 N 0.696 0.49 0.424073947737 gnomAD-4.0.0 1.593E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8613E-06 0 0
E/K 16923 Fn3-11 72 None 0.3118 None 0.999 N 0.612 0.291 0.32082282376 gnomAD-4.0.0 6.84537E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99774E-07 0 0
E/A 17217 Fn3-13 71 None 0.2953 None 0.704 N 0.376 0.21 0.379020345274 gnomAD-4.0.0 6.84539E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65777E-05
E/D 17217 Fn3-13 71 None 0.3415 None 0.704 N 0.357 0.11 0.229924730088 gnomAD-4.0.0 1.36909E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79971E-06 0 0
E/G 17217 Fn3-13 71 None 0.5146 None 0.826 N 0.43 0.274 0.428630128466 gnomAD-4.0.0 6.84539E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99849E-07 0 0
E/K 17217 Fn3-13 71 rs1060500503 0.6046 -0.732 0.704 N 0.39 0.223 0.311079019809 gnomAD-2.1.1 8.05E-06 None None None None N None 1.294E-04 0 None 0 0 None 0 None 0 0 0
E/K 17217 Fn3-13 71 rs1060500503 0.6046 -0.732 0.704 N 0.39 0.223 0.311079019809 gnomAD-4.0.0 3.42267E-06 None None None None N None 2.9933E-05 0 None 0 0 None 0 1.73792E-04 8.99849E-07 1.16009E-05 1.65772E-05
E/G 17440 Fn3-14 72 rs2055527887 0.4522 None 1.0 N 0.753 0.563 0.471052466308 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.95236E-04 None 0 0 0 0 0
E/G 17440 Fn3-14 72 rs2055527887 0.4522 None 1.0 N 0.753 0.563 0.471052466308 gnomAD-4.0.0 2.5668E-06 None None None None N None 0 0 None 0 2.44427E-05 None 0 0 0 0 2.85095E-05
E/K 17440 Fn3-14 72 None 0.4163 None 0.999 N 0.61 0.394 0.383921772103 gnomAD-4.0.0 1.59447E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43419E-05 0
D/N 17639 Fn3-16 71 None 0.1191 None 0.989 N 0.553 0.329 0.292787519742 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 1.94099E-04 0 None 0 0 1.3125E-06 0 0
E/A 17832 Fn3-17 69 None 0.2715 None 0.998 N 0.63 0.516 0.406945738958 gnomAD-4.0.0 2.05392E-05 None None None None N None 0 0 None 0 0 None 0 0 2.51963E-05 0 3.31565E-05
M/I 17932 Fn3-18 71 rs1195735577 0.8312 None 0.993 N 0.397 0.359 0.472504041403 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
M/T 17932 Fn3-18 71 None 0.7558 None 0.979 N 0.383 0.263 0.7014751448 gnomAD-4.0.0 6.8479E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00101E-07 0 0
Q/H 18136 Fn3-19 72 None 0.1907 None 0.927 N 0.423 0.074 0.154104182512 gnomAD-4.0.0 7.32324E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.78336E-05
K/R 18344 Fn3-21 73 None 0.0929 None 0.217 N 0.18 0.089 0.283761946502 gnomAD-4.0.0 1.59322E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86162E-06 0 0
E/D 18654 Fn3-23 76 rs2053252489 0.2412 None 0.977 N 0.482 0.236 0.26169431596 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/D 18654 Fn3-23 76 rs2053252489 0.2412 None 0.977 N 0.482 0.236 0.26169431596 gnomAD-4.0.0 6.57869E-06 None None None None N None 2.41418E-05 0 None 0 0 None 0 0 0 0 0
E/K 18654 Fn3-23 76 rs879244493 0.1209 None 0.955 N 0.533 0.307 0.198526703765 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/K 18654 Fn3-23 76 rs879244493 0.1209 None 0.955 N 0.533 0.307 0.198526703765 gnomAD-4.0.0 6.57981E-06 None None None None N None 2.41429E-05 0 None 0 0 None 0 0 0 0 0
E/V 18654 Fn3-23 76 None 0.1678 None 0.997 N 0.843 0.382 0.492134657179 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/V 18854 Fn3-24 71 None 0.2913 None 0.994 N 0.799 0.443 0.486779940545 gnomAD-4.0.0 1.43365E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.39454E-05 1.73762E-05
D/E 18958 Fn3-25 75 None 0.1197 None 0.002 N 0.11 0.078 0.136095386433 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
D/H 18958 Fn3-25 75 rs576158850 0.2939 -0.96 0.97 N 0.539 0.3 0.307966526162 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
D/H 18958 Fn3-25 75 rs576158850 0.2939 -0.96 0.97 N 0.539 0.3 0.307966526162 gnomAD-4.0.0 6.84403E-07 None None None None N None 0 0 None 0 2.52372E-05 None 0 0 0 0 0
D/N 18958 Fn3-25 75 rs576158850 0.0975 -0.322 0.91 N 0.479 0.197 None gnomAD-2.1.1 4.43E-05 None None None None N None 0 2.9E-05 None 0 2.79611E-04 None 0 None 0 4.46E-05 0
D/N 18958 Fn3-25 75 rs576158850 0.0975 -0.322 0.91 N 0.479 0.197 None gnomAD-3.1.2 5.92E-05 None None None None N None 4.83E-05 6.56E-05 0 0 0 None 0 0 7.36E-05 2.07297E-04 0
D/N 18958 Fn3-25 75 rs576158850 0.0975 -0.322 0.91 N 0.479 0.197 None 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
D/N 18958 Fn3-25 75 rs576158850 0.0975 -0.322 0.91 N 0.479 0.197 None gnomAD-4.0.0 5.64075E-05 None None None None N None 5.33518E-05 1.66756E-05 None 0 1.11717E-04 None 1.56226E-05 0 6.35871E-05 3.29497E-05 3.20195E-05
D/V 18958 Fn3-25 75 rs2052516508 0.1594 None 0.023 N 0.419 0.259 0.348983352498 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/V 18958 Fn3-25 75 rs2052516508 0.1594 None 0.023 N 0.419 0.259 0.348983352498 gnomAD-4.0.0 6.57843E-06 None None None None N None 2.41418E-05 0 None 0 0 None 0 0 0 0 0
A/D 19253 Fn3-27 71 rs1310871071 0.2577 -1.149 0.124 N 0.65 0.245 0.354183961838 gnomAD-2.1.1 4.8E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.11E-05 0
A/T 19253 Fn3-27 71 None 0.0882 None 0.124 N 0.506 0.088 0.1749357433 gnomAD-4.0.0 3.3199E-06 None None None None N None 0 0 None 0 0 None 0 0 5.95781E-06 0 0
A/V 19253 Fn3-27 71 rs1310871071 0.1546 None 0.22 N 0.563 0.229 0.267299060538 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/V 19253 Fn3-27 71 rs1310871071 0.1546 None 0.22 N 0.563 0.229 0.267299060538 gnomAD-4.0.0 6.57964E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47132E-05 0 0
T/N 19354 Fn3-28 71 None 0.2447 None 0.961 N 0.442 0.259 0.328486982098 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
D/Y 19549 Fn3-29 71 rs1472080899 0.2169 0.095 0.997 N 0.785 0.433 0.341696514166 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
D/Y 19549 Fn3-29 71 rs1472080899 0.2169 0.095 0.997 N 0.785 0.433 0.341696514166 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
D/Y 19549 Fn3-29 71 rs1472080899 0.2169 0.095 0.997 N 0.785 0.433 0.341696514166 gnomAD-4.0.0 4.33978E-06 None None None None N None 0 0 None 3.37952E-05 0 None 0 0 1.69559E-06 3.2946E-05 1.60195E-05
Q/H 19649 Fn3-30 71 rs886038922 0.2379 None None D 0.205 0.119 0.124217242631 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/H 19649 Fn3-30 71 rs886038922 0.2379 None None D 0.205 0.119 0.124217242631 gnomAD-4.0.0 4.95879E-06 None None None None N None 0 0 None 0 0 None 0 0 6.7821E-06 0 0
Q/E 19946 Fn3-32 70 None 0.0856 None 0.679 N 0.347 0.237 0.17948927462 gnomAD-4.0.0 6.84517E-07 None None None None N None 0 0 None 0 2.53331E-05 None 0 0 0 0 0
Q/K 19946 Fn3-32 70 rs758522183 0.1502 -0.414 0.679 N 0.4 0.233 0.177238962908 gnomAD-2.1.1 3.23E-05 None None None None N None 0 0 None 0 0 None 2.6166E-04 None 0 0 0
Q/K 19946 Fn3-32 70 rs758522183 0.1502 -0.414 0.679 N 0.4 0.233 0.177238962908 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
Q/K 19946 Fn3-32 70 rs758522183 0.1502 -0.414 0.679 N 0.4 0.233 0.177238962908 gnomAD-4.0.0 1.36397E-05 None None None None N None 0 0 None 0 0 None 0 0 0 2.41625E-04 0
Q/R 19946 Fn3-32 70 rs750885374 0.1631 -0.539 0.912 N 0.381 0.245 0.195762928549 gnomAD-2.1.1 3.23E-05 None None None None N None 0 0 None 0 0 None 2.61643E-04 None 0 0 0
Q/R 19946 Fn3-32 70 rs750885374 0.1631 -0.539 0.912 N 0.381 0.245 0.195762928549 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06868E-04 0
Q/R 19946 Fn3-32 70 rs750885374 0.1631 -0.539 0.912 N 0.381 0.245 0.195762928549 gnomAD-4.0.0 1.36393E-05 None None None None N None 0 0 None 0 0 None 0 0 0 2.41604E-04 0
E/K 20241 Fn3-34 71 None 0.2021 None 0.999 D 0.603 0.382 0.460881144077 gnomAD-4.0.0 6.84335E-07 None None None None N None 0 0 None 0 2.52029E-05 None 0 0 0 0 0
E/Q 20241 Fn3-34 71 rs200212521 0.1612 -0.584 1.0 N 0.609 0.337 None gnomAD-2.1.1 1.20048E-03 None None None None N None 1.2409E-04 2.26296E-04 None 0 0 None 1.63409E-04 None 4.31586E-03 1.62184E-03 7.03631E-04
E/Q 20241 Fn3-34 71 rs200212521 0.1612 -0.584 1.0 N 0.609 0.337 None gnomAD-3.1.2 1.1243E-03 None None None None N None 2.17181E-04 2.09808E-03 0 0 0 None 3.85773E-03 0 1.26474E-03 4.14079E-04 4.78927E-04
E/Q 20241 Fn3-34 71 rs200212521 0.1612 -0.584 1.0 N 0.609 0.337 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
E/Q 20241 Fn3-34 71 rs200212521 0.1612 -0.584 1.0 N 0.609 0.337 None gnomAD-4.0.0 1.30959E-03 None None None None N None 1.99984E-04 7.0014E-04 None 0 0 None 3.73426E-03 9.91408E-04 1.45138E-03 3.07456E-04 1.13666E-03
T/A 20340 Fn3-35 70 rs2050022624 0.0785 None 0.826 N 0.383 0.108 0.144782658237 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
T/A 20340 Fn3-35 70 rs2050022624 0.0785 None 0.826 N 0.383 0.108 0.144782658237 gnomAD-4.0.0 3.71994E-06 None None None None N None 0 0 None 0 0 None 0 1.64799E-04 2.54372E-06 1.09895E-05 1.602E-05
E/Q 20442 Fn3-36 72 rs751412533 0.2154 None 0.999 N 0.563 0.316 0.475112344478 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93874E-04 None 0 0 0 0 0
E/Q 20442 Fn3-36 72 rs751412533 0.2154 None 0.999 N 0.563 0.316 0.475112344478 gnomAD-4.0.0 6.57082E-06 None None None None N None 0 0 None 0 1.94326E-04 None 0 0 0 0 0
E/V 20637 Fn3-37 69 None 0.6605 None 1.0 N 0.793 0.544 0.627796283164 gnomAD-4.0.0 1.5918E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85945E-06 0 0
I/M 20738 Fn3-38 71 rs1388003753 0.1363 -0.556 0.934 N 0.486 0.143 0.431379191433 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.57E-05 0
I/M 20738 Fn3-38 71 rs1388003753 0.1363 -0.556 0.934 N 0.486 0.143 0.431379191433 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/M 20738 Fn3-38 71 rs1388003753 0.1363 -0.556 0.934 N 0.486 0.143 0.431379191433 gnomAD-4.0.0 6.81869E-06 None None None None N None 0 0 None 0 0 None 0 0 8.47719E-06 0 1.60159E-05
I/T 20738 Fn3-38 71 rs1455500759 0.2773 None 0.022 N 0.189 0.213 0.428630128466 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 20738 Fn3-38 71 rs1455500759 0.2773 None 0.022 N 0.189 0.213 0.428630128466 gnomAD-4.0.0 6.57938E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47163E-05 0 0
E/K 21033 Fn3-40 71 None 0.3093 None 0.992 N 0.523 0.372 0.366466682447 gnomAD-4.0.0 6.9166E-07 None None None None N None 0 0 None 0 0 None 0 0 9.04753E-07 0 0
E/K 21140 Fn3-41 77 rs765307639 0.2199 None 0.885 D 0.495 0.28 0.347659731818 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/K 21140 Fn3-41 77 rs765307639 0.2199 None 0.885 D 0.495 0.28 0.347659731818 gnomAD-4.0.0 1.86058E-06 None None None None N None 1.33579E-05 0 None 0 0 None 0 0 1.696E-06 0 0
E/Q 21140 Fn3-41 77 rs765307639 0.1576 -1.191 0.322 N 0.34 0.169 0.207176502487 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 5.66E-05 None 0 None 0 0 0
E/Q 21140 Fn3-41 77 rs765307639 0.1576 -1.191 0.322 N 0.34 0.169 0.207176502487 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94175E-04 None 0 0 0 0 0
E/Q 21140 Fn3-41 77 rs765307639 0.1576 -1.191 0.322 N 0.34 0.169 0.207176502487 gnomAD-4.0.0 1.86058E-06 None None None None N None 0 0 None 0 6.73098E-05 None 0 0 0 0 0
E/K 21335 Fn3-42 70 rs773791222 0.2098 -0.918 0.999 N 0.592 0.362 None gnomAD-2.1.1 2.14E-05 None None None None N None 2.06731E-04 0 None 0 0 None 0 None 0 7.82E-06 0
E/K 21335 Fn3-42 70 rs773791222 0.2098 -0.918 0.999 N 0.592 0.362 None gnomAD-3.1.2 5.26E-05 None None None None N None 1.93181E-04 0 0 0 0 None 0 0 0 0 0
E/K 21335 Fn3-42 70 rs773791222 0.2098 -0.918 0.999 N 0.592 0.362 None gnomAD-4.0.0 1.11583E-05 None None None None N None 1.87056E-04 0 None 0 0 None 0 0 1.69566E-06 0 3.2041E-05
E/A 21629 Fn3-44 71 None 0.2149 None 0.999 N 0.708 0.515 0.48512917806 gnomAD-4.0.0 1.59189E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85964E-06 0 0
E/D 21629 Fn3-44 71 rs779232091 0.277 -0.977 0.999 D 0.485 0.276 0.230578612272 gnomAD-2.1.1 7.15E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.57E-05 0
E/D 21629 Fn3-44 71 rs779232091 0.277 -0.977 0.999 D 0.485 0.276 0.230578612272 gnomAD-3.1.2 1.32E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
E/D 21629 Fn3-44 71 rs779232091 0.277 -0.977 0.999 D 0.485 0.276 0.230578612272 gnomAD-4.0.0 3.84484E-06 None None None None N None 1.6917E-05 0 None 0 0 None 0 0 4.78842E-06 0 0
E/K 21629 Fn3-44 71 rs746364765 0.3294 -0.543 0.999 N 0.615 0.396 0.430923071578 gnomAD-2.1.1 6.07E-05 None None None None N None 0 4.80769E-04 None 0 0 None 0 None 0 0 0
E/K 21629 Fn3-44 71 rs746364765 0.3294 -0.543 0.999 N 0.615 0.396 0.430923071578 gnomAD-3.1.2 3.29E-05 None None None None N None 0 3.27654E-04 0 0 0 None 0 0 0 0 0
E/K 21629 Fn3-44 71 rs746364765 0.3294 -0.543 0.999 N 0.615 0.396 0.430923071578 gnomAD-4.0.0 1.79749E-05 None None None None N None 0 4.16861E-04 None 0 6.69105E-05 None 0 0 8.47756E-07 0 0
E/G 21729 Fn3-45 71 rs1317452229 0.7059 None 1.0 N 0.733 0.563 0.465549362696 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 21729 Fn3-45 71 rs1317452229 0.7059 None 1.0 N 0.733 0.563 0.465549362696 gnomAD-4.0.0 6.57531E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47102E-05 0 0
E/K 21729 Fn3-45 71 rs375439506 0.8524 -0.607 0.999 N 0.611 0.424 0.326074293725 gnomAD-2.1.1 4.03E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
E/K 21729 Fn3-45 71 rs375439506 0.8524 -0.607 0.999 N 0.611 0.424 0.326074293725 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/K 21729 Fn3-45 71 rs375439506 0.8524 -0.607 0.999 N 0.611 0.424 0.326074293725 gnomAD-4.0.0 4.33928E-06 None None None None N None 2.67094E-05 0 None 0 0 None 0 1.64582E-04 1.69567E-06 1.09835E-05 1.60179E-05
E/Q 21729 Fn3-45 71 rs375439506 0.3943 None 1.0 N 0.631 0.392 None gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/Q 21729 Fn3-45 71 rs375439506 0.3943 None 1.0 N 0.631 0.392 None gnomAD-4.0.0 2.47959E-06 None None None None N None 2.67094E-05 0 None 0 0 None 0 0 0 2.19669E-05 0
Q/E 21829 Fn3-46 73 None 0.0969 None 0.349 N 0.392 0.205 0.158396225186 gnomAD-4.0.0 1.36967E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79982E-06 0 0
Q/R 21829 Fn3-46 73 rs886038921 0.1177 -0.124 0.008 N 0.235 0.215 0.112648838833 gnomAD-2.1.1 8.09E-06 None None None None N None 0 5.83E-05 None 0 0 None 0 None 0 0 0
Q/R 21829 Fn3-46 73 rs886038921 0.1177 -0.124 0.008 N 0.235 0.215 0.112648838833 gnomAD-4.0.0 3.18916E-06 None None None None N None 0 4.58127E-05 None 0 0 None 0 0 0 0 0
E/K 22025 Fn3-47 70 rs772896091 0.6663 -0.436 0.999 N 0.607 0.312 0.406945738958 gnomAD-2.1.1 8.07E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 8.91E-06 0
E/K 22025 Fn3-47 70 rs772896091 0.6663 -0.436 0.999 N 0.607 0.312 0.406945738958 gnomAD-4.0.0 3.18683E-06 None None None None N None 0 2.28938E-05 None 0 0 None 0 0 2.86134E-06 0 0
E/G 22125 Fn3-48 71 None 0.3881 None 1.0 N 0.702 0.472 0.433600339574 gnomAD-4.0.0 1.59223E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86025E-06 0 0
E/K 22125 Fn3-48 71 rs752675920 0.2746 -0.854 1.0 N 0.591 0.385 0.355865052028 gnomAD-2.1.1 2.82E-05 None None None None N None 0 1.73963E-04 None 0 5.59E-05 None 0 None 0 0 0
E/K 22125 Fn3-48 71 rs752675920 0.2746 -0.854 1.0 N 0.591 0.385 0.355865052028 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 22125 Fn3-48 71 rs752675920 0.2746 -0.854 1.0 N 0.591 0.385 0.355865052028 gnomAD-4.0.0 8.05873E-06 None None None None N None 0 1.00077E-04 None 0 2.23404E-05 None 0 0 3.39127E-06 0 3.20359E-05
Q/P 22227 Fn3-49 72 rs1403005823 0.0618 None 0.028 N 0.403 0.228 0.270001397563 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
Q/P 22227 Fn3-49 72 rs1403005823 0.0618 None 0.028 N 0.403 0.228 0.270001397563 gnomAD-4.0.0 6.57566E-06 None None None None N None 2.41289E-05 0 None 0 0 None 0 0 0 0 0
Q/R 22227 Fn3-49 72 rs1403005823 0.1353 None 0.007 N 0.265 0.219 0.130388298395 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
Q/R 22227 Fn3-49 72 rs1403005823 0.1353 None 0.007 N 0.265 0.219 0.130388298395 gnomAD-4.0.0 6.57566E-06 None None None None N None 2.41289E-05 0 None 0 0 None 0 0 0 0 0
S/C 22423 Fn3-50 70 None 0.0881 None 0.994 N 0.479 0.445 0.41337360676 gnomAD-4.0.0 8.40235E-06 None None None None N None 0 0 None 0 0 None 0 0 9.18763E-06 0 0
S/P 22423 Fn3-50 70 None 0.2136 None 0.007 N 0.229 0.193 0.126345400529 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
E/K 22518 Fn3-51 68 rs371063328 0.132 0.119 0.865 N 0.528 0.235 None gnomAD-2.1.1 8.05E-06 None None None None N None 1.29216E-04 0 None 0 0 None 0 None 0 0 0
E/K 22518 Fn3-51 68 rs371063328 0.132 0.119 0.865 N 0.528 0.235 None gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/K 22518 Fn3-51 68 rs371063328 0.132 0.119 0.865 N 0.528 0.235 None gnomAD-4.0.0 1.31543E-05 None None None None N None 4.82812E-05 0 None 0 0 None 0 0 0 0 0
E/Q 22518 Fn3-51 68 None 0.1178 None 0.284 N 0.244 0.165 0.248417906384 gnomAD-4.0.0 2.40078E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62517E-06 0 0
E/D 22713 Fn3-52 71 rs768845661 0.4371 -1.129 0.999 D 0.471 0.304 0.298403945805 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
E/D 22713 Fn3-52 71 rs768845661 0.4371 -1.129 0.999 D 0.471 0.304 0.298403945805 gnomAD-4.0.0 1.5923E-06 None None None None N None 0 0 None 0 2.77747E-05 None 0 0 0 0 0
E/K 22713 Fn3-52 71 rs895744220 0.5388 None 0.999 N 0.585 0.354 0.317958651998 gnomAD-4.0.0 2.73762E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59876E-06 0 0
E/Q 22713 Fn3-52 71 rs895744220 0.2752 -0.878 1.0 N 0.611 0.334 0.297031009988 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 6.5445E-04 None 0 None 0 0 0
E/Q 22713 Fn3-52 71 rs895744220 0.2752 -0.878 1.0 N 0.611 0.334 0.297031009988 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93874E-04 None 0 0 0 0 0
E/Q 22713 Fn3-52 71 rs895744220 0.2752 -0.878 1.0 N 0.611 0.334 0.297031009988 gnomAD-4.0.0 1.85966E-06 None None None None N None 0 0 None 0 6.69762E-05 None 0 0 0 0 0
E/K 22813 Fn3-53 71 None 0.7275 -0.689 0.999 N 0.627 0.358 None gnomAD-2.1.1 3.04134E-04 None None None None N None 0 5.66E-05 None 7.26041E-03 0 None 0 None 0 4.7E-05 2.81849E-04
E/K 22813 Fn3-53 71 None 0.7275 -0.689 0.999 N 0.627 0.358 None gnomAD-3.1.2 1.77552E-04 None None None None N None 0 1.31148E-04 0 6.05536E-03 0 None 0 0 5.88E-05 0 0
E/K 22813 Fn3-53 71 None 0.7275 -0.689 0.999 N 0.627 0.358 None gnomAD-4.0.0 1.65513E-04 None None None None N None 1.33554E-05 5.00283E-05 None 6.86228E-03 0 None 0 0 2.79782E-05 0 4.32429E-04
E/Q 22813 Fn3-53 71 rs200797552 0.3075 None 1.0 N 0.653 0.335 0.347879110917 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93424E-04 None 0 0 0 0 0
E/Q 22813 Fn3-53 71 rs200797552 0.3075 None 1.0 N 0.653 0.335 0.347879110917 gnomAD-4.0.0 1.23971E-06 None None None None N None 0 0 None 0 4.46887E-05 None 0 0 0 0 0
E/A 23109 Fn3-55 70 rs1212757037 0.7244 -1.211 0.958 N 0.648 0.511 0.418344901717 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
E/A 23109 Fn3-55 70 rs1212757037 0.7244 -1.211 0.958 N 0.648 0.511 0.418344901717 gnomAD-4.0.0 1.36865E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79922E-06 0 0
E/D 23109 Fn3-55 70 None 0.7415 None 0.067 N 0.205 0.181 0.280987212366 gnomAD-4.0.0 1.59189E-06 None None None None N None 0 0 None 0 0 None 0 2.41546E-04 0 0 0
E/K 23109 Fn3-55 70 rs727503571 0.7478 None 0.958 N 0.549 0.345 0.377097596864 gnomAD-3.1.2 1.32E-05 None None None None N None 0 6.55E-05 0 0 1.93648E-04 None 0 0 0 0 0
E/K 23109 Fn3-55 70 rs727503571 0.7478 None 0.958 N 0.549 0.345 0.377097596864 gnomAD-4.0.0 3.04523E-06 None None None None N None 0 6.15536E-05 None 0 1.13714E-04 None 0 0 1.205E-06 0 0
T/I 23209 Fn3-56 71 rs910182014 0.0958 None 0.175 N 0.429 0.152 0.223847106136 gnomAD-4.0.0 6.84284E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99562E-07 0 0
T/P 23209 Fn3-56 71 None 0.1051 None 0.175 N 0.387 0.232 0.193865811164 gnomAD-4.0.0 1.59163E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85915E-06 0 0
T/S 23209 Fn3-56 71 rs910182014 0.0799 -1.162 None N 0.115 0.105 0.148003135375 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/S 23209 Fn3-56 71 rs910182014 0.0799 -1.162 None N 0.115 0.105 0.148003135375 gnomAD-4.0.0 1.36857E-06 None None None None N None 0 4.47227E-05 None 0 0 None 0 0 0 0 0
K/R 23311 Fn3-57 72 rs1025638052 0.088 None 0.892 N 0.471 0.26 0.354396617058 gnomAD-4.0.0 1.59333E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02828E-05
E/D 23504 Fn3-58 70 None 0.1413 None None N 0.109 0.083 0.240491677333 gnomAD-4.0.0 6.84291E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99557E-07 0 0
E/Q 23504 Fn3-58 70 rs1362847983 0.1869 -0.858 0.002 N 0.199 0.116 0.275641507738 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 0 9.19118E-04
E/Q 23504 Fn3-58 70 rs1362847983 0.1869 -0.858 0.002 N 0.199 0.116 0.275641507738 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/Q 23504 Fn3-58 70 rs1362847983 0.1869 -0.858 0.002 N 0.199 0.116 0.275641507738 gnomAD-4.0.0 5.07505E-06 None None None None N None 0 6.15612E-05 None 0 0 None 0 0 3.61491E-06 0 3.40298E-05
E/A 23600 Fn3-59 69 rs1168061388 0.2214 -0.729 0.945 N 0.531 0.315 0.378847511475 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
E/A 23600 Fn3-59 69 rs1168061388 0.2214 -0.729 0.945 N 0.531 0.315 0.378847511475 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/A 23600 Fn3-59 69 rs1168061388 0.2214 -0.729 0.945 N 0.531 0.315 0.378847511475 gnomAD-4.0.0 6.57488E-06 None None None None N None 2.41255E-05 0 None 0 0 None 0 0 0 0 0
E/D 23600 Fn3-59 69 None 0.4354 None 0.815 N 0.423 0.179 0.358134431457 gnomAD-4.0.0 1.59193E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85919E-06 0 0
E/G 23600 Fn3-59 69 None 0.4415 None 0.998 N 0.695 0.404 0.424313518543 gnomAD-4.0.0 2.40067E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62502E-06 0 0
E/D 23796 Fn3-60 71 rs878854330 0.4513 None 0.008 N 0.151 0.079 0.12205267543 gnomAD-4.0.0 1.59336E-06 None None None None N None 5.66059E-05 0 None 0 0 None 0 0 0 0 0
E/V 23796 Fn3-60 71 None 0.3848 None 0.949 N 0.719 0.459 0.566737540366 gnomAD-4.0.0 1.59334E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8618E-06 0 0
A/T 23994 Fn3-62 71 rs2154171332 0.0764 None 0.01 N 0.101 0.1 0.112648838833 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
A/V 23994 Fn3-62 71 rs772886864 0.1075 -0.291 0.27 N 0.33 0.15 0.240491677333 gnomAD-2.1.1 3.22E-05 None None None None N None 0 1.15949E-04 None 9.97E-05 0 None 0 None 0 1.78E-05 1.65837E-04
A/V 23994 Fn3-62 71 rs772886864 0.1075 -0.291 0.27 N 0.33 0.15 0.240491677333 gnomAD-3.1.2 2.63E-05 None None None None N None 0 2.61917E-04 0 0 0 None 0 0 0 0 0
A/V 23994 Fn3-62 71 rs772886864 0.1075 -0.291 0.27 N 0.33 0.15 0.240491677333 gnomAD-4.0.0 1.67338E-05 None None None None N None 0 2.3338E-04 None 1.01386E-04 0 None 0 0 5.08615E-06 0 6.40492E-05
E/D 24394 Fn3-65 72 rs750460710 0.1408 -1.259 0.434 N 0.221 0.117 0.254761474806 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66445E-04
E/D 24394 Fn3-65 72 rs750460710 0.1408 -1.259 0.434 N 0.221 0.117 0.254761474806 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/D 24394 Fn3-65 72 rs750460710 0.1408 -1.259 0.434 N 0.221 0.117 0.254761474806 gnomAD-4.0.0 7.43885E-06 None None None None N None 0 0 None 0 0 None 0 0 1.01733E-05 0 0
E/A 24684 Fn3-67 69 None 0.3303 None 0.997 N 0.604 0.441 0.403896168776 gnomAD-4.0.0 6.8443E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9962E-07 0 0
E/G 24684 Fn3-67 69 rs767059836 0.612 -1.649 1.0 N 0.735 0.5 0.460438652622 gnomAD-4.0.0 6.8443E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9962E-07 0 0
E/V 24684 Fn3-67 69 None 0.3832 None 0.999 N 0.805 0.456 0.508994031223 gnomAD-4.0.0 6.8443E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9962E-07 0 0
E/Q 24978 Fn3-69 71 rs1708062798 0.2231 None 0.994 N 0.62 0.277 0.234412748748 gnomAD-4.0.0 1.59182E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85923E-06 0 0
R/S 25076 Fn3-70 71 rs758951524 0.4885 -0.978 0.491 N 0.36 0.175 0.17948927462 gnomAD-2.1.1 8.05E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 1.65837E-04
R/S 25076 Fn3-70 71 rs758951524 0.4885 -0.978 0.491 N 0.36 0.175 0.17948927462 gnomAD-4.0.0 3.18342E-06 None None None None N None 0 2.28666E-05 None 0 0 None 0 0 0 0 3.02499E-05
D/G 25374 Fn3-72 71 None 0.1978 None 0.012 N 0.389 0.078 0.178374595973 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/H 25374 Fn3-72 71 None 0.1515 None 0.001 N 0.291 0.104 0.0482279557977 gnomAD-4.0.0 6.84549E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16025E-05 0
D/N 25374 Fn3-72 71 rs368715583 0.0698 -1.695 None N 0.107 0.116 None gnomAD-2.1.1 1.21E-05 None None None None N None 6.46E-05 0 None 0 0 None 3.27E-05 None 0 8.94E-06 0
D/N 25374 Fn3-72 71 rs368715583 0.0698 -1.695 None N 0.107 0.116 None gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/N 25374 Fn3-72 71 rs368715583 0.0698 -1.695 None N 0.107 0.116 None gnomAD-4.0.0 1.11604E-05 None None None None N None 4.00769E-05 0 None 0 0 None 0 0 1.01748E-05 2.19751E-05 1.60185E-05
E/D 25476 Fn3-73 72 None 0.2633 None 0.958 N 0.403 0.21 0.303781844768 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 25476 Fn3-73 72 rs868426391 0.1089 None 0.958 N 0.464 0.284 0.295623431141 gnomAD-4.0.0 1.36908E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.31587E-05
S/G 25670 Fn3-74 70 None 0.0963 None 0.732 N 0.342 0.218 0.210429274316 gnomAD-4.0.0 2.73734E-06 None None None None N None 2.99043E-05 0 None 0 0 None 0 0 2.69883E-06 0 0
S/T 25670 Fn3-74 70 rs774024917 0.0709 -0.104 0.147 N 0.371 0.085 0.149567049428 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
S/T 25670 Fn3-74 70 rs774024917 0.0709 -0.104 0.147 N 0.371 0.085 0.149567049428 gnomAD-3.1.2 1.97E-05 None None None None N None 4.83E-05 6.56E-05 0 0 0 None 0 0 0 0 0
S/T 25670 Fn3-74 70 rs774024917 0.0709 -0.104 0.147 N 0.371 0.085 0.149567049428 gnomAD-4.0.0 5.07503E-06 None None None None N None 3.49504E-05 6.15839E-05 None 0 0 None 0 0 0 0 6.80504E-05
E/K 25960 Fn3-76 71 rs367624488 0.4382 -0.73 0.958 N 0.554 0.382 None gnomAD-2.1.1 8.57E-05 None None None None N None 9.51042E-04 2.83E-05 None 0 0 None 0 None 0 0 0
E/K 25960 Fn3-76 71 rs367624488 0.4382 -0.73 0.958 N 0.554 0.382 None gnomAD-3.1.2 2.56505E-04 None None None None N None 9.17786E-04 6.56E-05 0 0 0 None 0 0 0 0 0
E/K 25960 Fn3-76 71 rs367624488 0.4382 -0.73 0.958 N 0.554 0.382 None gnomAD-4.0.0 4.95855E-05 None None None None N None 1.02861E-03 5.00334E-05 None 0 0 None 0 0 0 0 0
R/K 26158 Fn3-78 71 None 0.1217 None None N 0.106 0.086 0.143124449307 gnomAD-4.0.0 6.84868E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00171E-07 0 0
R/T 26158 Fn3-78 71 rs1248526272 0.2426 -0.599 0.324 N 0.372 0.236 0.357519025918 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
R/T 26158 Fn3-78 71 rs1248526272 0.2426 -0.599 0.324 N 0.372 0.236 0.357519025918 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/T 26158 Fn3-78 71 rs1248526272 0.2426 -0.599 0.324 N 0.372 0.236 0.357519025918 gnomAD-4.0.0 2.48105E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39298E-06 0 0
E/A 26456 Fn3-80 71 rs767070836 0.2539 -1.446 0.994 N 0.561 0.535 0.479518371956 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 0 0
E/A 26456 Fn3-80 71 rs767070836 0.2539 -1.446 0.994 N 0.561 0.535 0.479518371956 gnomAD-4.0.0 1.11453E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.00301E-04 0
E/K 26456 Fn3-80 71 rs1706025148 0.439 None 0.989 N 0.462 0.334 0.4018988957 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/K 26456 Fn3-80 71 rs1706025148 0.439 None 0.989 N 0.462 0.334 0.4018988957 gnomAD-4.0.0 1.5225E-05 None None None None N None 6.98983E-05 0 None 0 0 None 0 0 1.32544E-05 0 0
E/A 26558 Fn3-81 72 None 0.126 None 0.805 N 0.531 0.372 0.395894371353 gnomAD-4.0.0 2.73734E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59808E-06 0 0
E/K 26558 Fn3-81 72 rs1466993099 0.2057 -1.111 0.805 N 0.501 0.293 0.319970858106 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
E/K 26558 Fn3-81 72 rs1466993099 0.2057 -1.111 0.805 N 0.501 0.293 0.319970858106 gnomAD-4.0.0 2.73741E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59807E-06 0 0
E/Q 26558 Fn3-81 72 None 0.146 None 0.204 N 0.263 0.187 0.190952846119 gnomAD-4.0.0 2.73741E-06 None None None None N None 2.989E-05 0 None 0 0 None 1.88034E-05 0 8.99518E-07 1.15937E-05 0
E/V 26558 Fn3-81 72 rs1026820295 0.1779 None 0.935 N 0.68 0.426 0.568143352941 gnomAD-4.0.0 1.36867E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.31389E-05
I/V 26752 Fn3-82 70 rs376046847 0.0628 None 0.099 N 0.261 0.073 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
I/V 26752 Fn3-82 70 rs376046847 0.0628 None 0.099 N 0.261 0.073 None gnomAD-4.0.0 3.04501E-06 None None None None N None 3.49443E-05 0 None 0 0 None 0 0 1.20496E-06 0 0
E/Q 26848 Fn3-83 69 rs898433512 0.273 None 0.991 N 0.615 0.319 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/Q 26848 Fn3-83 69 rs898433512 0.273 None 0.991 N 0.615 0.319 None gnomAD-4.0.0 1.31494E-05 None None None None N None 4.82556E-05 0 None 0 0 None 0 0 0 0 0
E/D 27042 Fn3-84 71 rs766412271 0.5477 -1.033 0.999 N 0.471 0.364 0.181679512989 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
E/D 27042 Fn3-84 71 rs766412271 0.5477 -1.033 0.999 N 0.471 0.364 0.181679512989 gnomAD-4.0.0 1.59287E-06 None None None None N None 0 0 None 0 2.77362E-05 None 0 0 0 0 0
E/V 27042 Fn3-84 71 None 0.4715 None 1.0 N 0.799 0.592 0.612639375224 gnomAD-4.0.0 1.59263E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86008E-06 0 0
E/K 27142 Fn3-85 71 None 0.5613 None 0.822 N 0.493 0.247 0.292787519742 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
R/I 27240 Fn3-86 71 rs1704895564 0.3521 None 0.379 N 0.519 0.273 0.33110744837 gnomAD-4.0.0 4.77754E-06 None None None None N None 0 0 None 0 8.35375E-05 None 0 0 0 0 0
R/S 27240 Fn3-86 71 rs1704894425 0.5897 None 0.016 N 0.285 0.219 0.151104730317 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/S 27240 Fn3-86 71 rs1704894425 0.5897 None 0.016 N 0.285 0.219 0.151104730317 gnomAD-4.0.0 6.57255E-06 None None None None N None 2.41196E-05 0 None 0 0 None 0 0 0 0 0
E/K 27439 Fn3-87 71 rs748460030 0.5232 -0.551 0.892 N 0.503 0.3 0.357519025918 gnomAD-2.1.1 7.15E-06 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 0 0
E/K 27439 Fn3-87 71 rs748460030 0.5232 -0.551 0.892 N 0.503 0.3 0.357519025918 gnomAD-3.1.2 1.97E-05 None None None None N None 7.25E-05 0 0 0 0 None 0 0 0 0 0
E/K 27439 Fn3-87 71 rs748460030 0.5232 -0.551 0.892 N 0.503 0.3 0.357519025918 gnomAD-4.0.0 3.0987E-06 None None None None N None 4.00662E-05 0 None 0 0 None 0 0 1.69527E-06 0 0
S/C 27539 Fn3-88 71 rs727503556 0.0815 -0.343 0.987 N 0.489 0.305 None gnomAD-2.1.1 1.21E-05 None None None None N None 1.93798E-04 0 None 0 0 None 0 None 0 0 0
S/C 27539 Fn3-88 71 rs727503556 0.0815 -0.343 0.987 N 0.489 0.305 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
S/C 27539 Fn3-88 71 rs727503556 0.0815 -0.343 0.987 N 0.489 0.305 None gnomAD-4.0.0 4.9577E-06 None None None None N None 1.06792E-04 0 None 0 0 None 0 0 0 0 0
S/T 27539 Fn3-88 71 None 0.0894 None 0.003 N 0.145 0.073 0.148003135375 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 1.94099E-04 0 None 0 0 0 0 0
E/K 27641 Fn3-89 72 None 0.1338 None 0.999 N 0.589 0.389 0.354396617058 gnomAD-4.0.0 6.84252E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65684E-05
E/Q 27641 Fn3-89 72 None 0.1166 None 1.0 N 0.614 0.395 0.273938319068 gnomAD-4.0.0 2.05276E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69857E-06 0 0
E/A 27931 Fn3-91 69 None 0.2439 None 0.972 N 0.617 0.358 0.365317461125 gnomAD-4.0.0 1.02782E-05 None None None None N None 0 0 None 0 0 None 0 0 1.35009E-05 0 0
E/D 27931 Fn3-91 69 rs767740501 0.3392 -1.058 0.815 N 0.446 0.157 0.294206760003 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 0 None 4.73E-05 0 0
E/K 27931 Fn3-91 69 rs752902445 0.4798 -0.639 0.969 N 0.512 0.293 0.279776271856 gnomAD-2.1.1 1.81E-05 None None None None N None 0 5.72E-05 None 0 0 None 0 None 0 2.36E-05 0
E/K 27931 Fn3-91 69 rs752902445 0.4798 -0.639 0.969 N 0.512 0.293 0.279776271856 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/K 27931 Fn3-91 69 rs752902445 0.4798 -0.639 0.969 N 0.512 0.293 0.279776271856 gnomAD-4.0.0 1.79975E-05 None None None None N None 0 6.69703E-05 None 0 0 None 0 0 2.1205E-05 0 0
E/V 27931 Fn3-91 69 None 0.3479 None 0.987 N 0.787 0.391 0.458101713262 gnomAD-4.0.0 6.85213E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00061E-07 0 0
E/K 28124 Fn3-92 70 rs1295072546 0.2341 -0.308 0.999 N 0.621 0.381 0.36453787251 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
E/K 28124 Fn3-92 70 rs1295072546 0.2341 -0.308 0.999 N 0.621 0.381 0.36453787251 gnomAD-4.0.0 1.36864E-06 None None None None N None 0 0 None 0 0 None 1.87357E-05 0 8.99536E-07 0 0
M/I 28224 Fn3-93 71 rs761882110 0.335 -0.671 0.012 N 0.301 0.164 0.448201132538 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
M/I 28224 Fn3-93 71 rs761882110 0.335 -0.671 0.012 N 0.301 0.164 0.448201132538 gnomAD-4.0.0 4.10532E-06 None None None None N None 0 0 None 0 0 None 0 0 4.4974E-06 1.15937E-05 0
M/L 28224 Fn3-93 71 None 0.0996 None None N 0.082 0.08 0.231231049324 gnomAD-4.0.0 1.20033E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
M/R 28224 Fn3-93 71 None 0.3465 None 0.055 N 0.446 0.187 0.465294738428 gnomAD-4.0.0 6.84221E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9948E-07 0 0
M/T 28224 Fn3-93 71 rs769942168 0.2149 -1.024 0.024 N 0.411 0.163 0.467839254973 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
M/T 28224 Fn3-93 71 rs769942168 0.2149 -1.024 0.024 N 0.411 0.163 0.467839254973 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/T 28224 Fn3-93 71 rs769942168 0.2149 -1.024 0.024 N 0.411 0.163 0.467839254973 gnomAD-4.0.0 6.19695E-06 None None None None N None 1.33447E-05 0 None 0 0 None 0 0 7.62858E-06 0 0
R/C 28322 Fn3-94 71 rs774978209 0.1608 -1.072 0.999 N 0.521 0.354 0.51847606553 gnomAD-2.1.1 2.42E-05 None None None None N None 1.29216E-04 0 None 0 0 None 1.3071E-04 None 0 0 0
R/C 28322 Fn3-94 71 rs774978209 0.1608 -1.072 0.999 N 0.521 0.354 0.51847606553 gnomAD-3.1.2 3.94E-05 None None None None N None 1.20685E-04 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 28322 Fn3-94 71 rs774978209 0.1608 -1.072 0.999 N 0.521 0.354 0.51847606553 gnomAD-4.0.0 2.72708E-05 None None None None N None 8.01068E-05 0 None 0 0 None 0 0 2.54281E-05 7.68589E-05 1.60118E-05
R/H 28322 Fn3-94 71 rs373532064 0.113 -1.666 0.081 N 0.178 0.184 None gnomAD-2.1.1 5.36E-05 None None None None N None 8.27E-05 0 None 0 5.14E-05 None 0 None 0 9.4E-05 0
R/H 28322 Fn3-94 71 rs373532064 0.113 -1.666 0.081 N 0.178 0.184 None gnomAD-3.1.2 8.54E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 1.47029E-04 0 0
R/H 28322 Fn3-94 71 rs373532064 0.113 -1.666 0.081 N 0.178 0.184 None gnomAD-4.0.0 1.13414E-04 None None None None N None 4.00491E-05 0 None 0 0 None 0 0 1.4155E-04 0 2.0814E-04
E/Q 28620 Fn3-96 71 None 0.2042 None 0.991 N 0.621 0.328 0.297718772494 gnomAD-4.0.0 1.59123E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8582E-06 0 0
E/Q 28720 Fn3-97 70 None 0.1188 None 1.0 N 0.628 0.34 0.242244723065 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 28914 Fn3-98 70 rs786205373 0.0549 -0.909 None N 0.096 0.048 0.128392430309 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
I/V 28914 Fn3-98 70 rs786205373 0.0549 -0.909 None N 0.096 0.048 0.128392430309 gnomAD-4.0.0 2.05281E-06 None None None None N None 0 0 None 0 0 None 0 0 2.6987E-06 0 0
E/A 29010 Fn3-99 69 rs1702336560 0.2201 None 0.958 N 0.583 0.39 0.381746406553 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/A 29010 Fn3-99 69 rs1702336560 0.2201 None 0.958 N 0.583 0.39 0.381746406553 gnomAD-4.0.0 2.56226E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78558E-06 0 0
E/K 29207 Fn3-100 71 rs1403726987 0.4246 -0.815 0.805 N 0.503 0.294 0.369495900351 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
E/K 29207 Fn3-100 71 rs1403726987 0.4246 -0.815 0.805 N 0.503 0.294 0.369495900351 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 29207 Fn3-100 71 rs1403726987 0.4246 -0.815 0.805 N 0.503 0.294 0.369495900351 gnomAD-4.0.0 4.95735E-06 None None None None N None 0 0 None 0 0 None 0 0 6.7807E-06 0 0
I/F 29307 Fn3-101 71 None 0.3348 None 0.901 N 0.575 0.23 0.531972677126 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/T 29307 Fn3-101 71 rs1332665618 0.4742 -2.106 0.722 N 0.575 0.322 0.574366754605 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
I/T 29307 Fn3-101 71 rs1332665618 0.4742 -2.106 0.722 N 0.575 0.322 0.574366754605 gnomAD-4.0.0 3.182E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71553E-06 0 0
Q/L 29405 Fn3-102 71 rs777999009 0.1698 None 0.425 N 0.403 0.168 0.432154444652 gnomAD-4.0.0 6.84214E-07 None None None None N None 2.98721E-05 0 None 0 0 None 0 0 0 0 0
Q/R 29405 Fn3-102 71 rs777999009 0.1081 -0.442 0.006 N 0.145 0.109 0.128392430309 gnomAD-2.1.1 4.83E-05 None None None None N None 0 2.9E-05 None 0 0 None 3.59501E-04 None 0 0 0
Q/R 29405 Fn3-102 71 rs777999009 0.1081 -0.442 0.006 N 0.145 0.109 0.128392430309 gnomAD-4.0.0 2.05264E-05 None None None None N None 0 2.23594E-05 None 0 0 None 0 0 0 3.24615E-04 1.65656E-05
E/K 29603 Fn3-103 71 rs777572153 0.5084 -0.501 0.999 N 0.606 0.387 0.357724736475 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.8E-05 None 0 0 0
E/K 29603 Fn3-103 71 rs777572153 0.5084 -0.501 0.999 N 0.606 0.387 0.357724736475 gnomAD-4.0.0 1.27303E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.14623E-04 0
D/E 29703 Fn3-104 71 rs1368949216 0.11 -0.782 None N 0.13 0.143 0.0762999501168 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/V 29703 Fn3-104 71 rs1700334613 0.1498 None 0.117 N 0.597 0.242 0.46512379133 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.41E-05 0 0 0 0
D/V 29703 Fn3-104 71 rs1700334613 0.1498 None 0.117 N 0.597 0.242 0.46512379133 gnomAD-4.0.0 3.84485E-06 None None None None N None 0 0 None 0 0 None 4.73754E-05 0 0 0 0
D/Y 29703 Fn3-104 71 rs1429421793 0.1817 -0.573 0.741 N 0.672 0.287 0.520803792171 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 0 0
D/Y 29703 Fn3-104 71 rs1429421793 0.1817 -0.573 0.741 N 0.672 0.287 0.520803792171 gnomAD-4.0.0 1.75151E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.57607E-04 0
N/S 29805 Fn3-105 72 rs369285180 0.0876 -0.618 0.027 N 0.402 0.206 None gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.56E-05 0
N/S 29805 Fn3-105 72 rs369285180 0.0876 -0.618 0.027 N 0.402 0.206 None gnomAD-3.1.2 3.28E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 4.41E-05 0 0
N/S 29805 Fn3-105 72 rs369285180 0.0876 -0.618 0.027 N 0.402 0.206 None gnomAD-4.0.0 1.04102E-04 None None None None N None 5.33775E-05 0 None 0 0 None 0 0 1.39004E-04 0 0
P/T 30002 Fn3-106 70 None 0.1171 None 0.454 N 0.379 0.182 0.236890367714 gnomAD-4.0.0 1.59126E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
V/F 30098 Fn3-107 69 rs1221691128 0.1874 -0.983 0.188 N 0.468 0.076 0.434825671192 gnomAD-2.1.1 6.37E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.29634E-04 0
V/F 30098 Fn3-107 69 rs1221691128 0.1874 -0.983 0.188 N 0.468 0.076 0.434825671192 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
V/F 30098 Fn3-107 69 rs1221691128 0.1874 -0.983 0.188 N 0.468 0.076 0.434825671192 gnomAD-4.0.0 8.67536E-06 None None None None N None 0 0 None 0 0 None 0 0 1.01709E-05 0 3.20195E-05
V/I 30098 Fn3-107 69 None 0.0708 None None N 0.239 0.052 0.180583059064 gnomAD-4.0.0 2.05254E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79887E-06 1.15937E-05 0
E/A 30294 Fn3-108 71 None 0.2061 None 0.989 N 0.573 0.559 0.469333501611 gnomAD-4.0.0 1.59281E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86157E-06 0 0
E/D 30294 Fn3-108 71 None 0.3177 None 0.989 N 0.43 0.219 0.240491677333 gnomAD-4.0.0 2.05356E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69941E-06 0 0
D/E 30394 Fn3-109 71 None 0.2572 None 0.198 N 0.237 0.132 0.12205267543 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/C 30491 Fn3-110 70 rs1699239943 0.2518 None 1.0 N 0.766 0.474 0.521546690486 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 30491 Fn3-110 70 rs1699239943 0.2518 None 1.0 N 0.766 0.474 0.521546690486 gnomAD-4.0.0 3.09954E-06 None None None None N None 0 0 None 0 0 None 0 0 3.391E-06 1.09856E-05 0
R/G 30491 Fn3-110 70 None 0.4138 None 1.0 N 0.723 0.454 0.45461005305 gnomAD-4.0.0 2.73776E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.64016E-05 0
R/H 30491 Fn3-110 70 rs765777852 0.1477 -1.186 1.0 N 0.725 0.409 0.27855597813 gnomAD-2.1.1 1.43E-05 None None None None N None 1.24275E-04 0 None 0 0 None 0 None 0 7.84E-06 0
R/H 30491 Fn3-110 70 rs765777852 0.1477 -1.186 1.0 N 0.725 0.409 0.27855597813 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/H 30491 Fn3-110 70 rs765777852 0.1477 -1.186 1.0 N 0.725 0.409 0.27855597813 gnomAD-4.0.0 4.95925E-06 None None None None N None 6.67789E-05 3.33667E-05 None 0 0 None 0 0 0 0 1.60205E-05
E/Q 30689 Fn3-111 71 None 0.3242 None 1.0 N 0.628 0.355 0.294206760003 gnomAD-4.0.0 1.36843E-06 None None None None N None 0 0 None 0 0 None 0 0 8.9948E-07 0 1.65667E-05
E/K 30790 Fn3-112 72 rs371765494 0.574 -1.089 0.999 N 0.596 0.263 None gnomAD-2.1.1 8.03E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
E/K 30790 Fn3-112 72 rs371765494 0.574 -1.089 0.999 N 0.596 0.263 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 30790 Fn3-112 72 rs371765494 0.574 -1.089 0.999 N 0.596 0.263 None gnomAD-4.0.0 4.33763E-06 None None None None N None 1.33479E-05 3.33411E-05 None 0 2.22886E-05 None 0 0 1.69512E-06 0 1.60108E-05
E/Q 30891 Fn3-113 71 None 0.1613 None 0.801 N 0.471 0.193 0.227260227426 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/L 31085 Fn3-114 70 rs549841864 0.185 0.194 0.999 N 0.748 0.417 None gnomAD-2.1.1 1.39443E-04 None None None None N None 4.13E-05 2.83E-05 None 0 1.58811E-03 None 1.30719E-04 None 0 0 2.81215E-04
P/L 31085 Fn3-114 70 rs549841864 0.185 0.194 0.999 N 0.748 0.417 None gnomAD-3.1.2 1.05193E-04 None None None None N None 2.41E-05 6.56E-05 0 0 2.12028E-03 None 0 0 0 6.22407E-04 0
P/L 31085 Fn3-114 70 rs549841864 0.185 0.194 0.999 N 0.748 0.417 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
P/L 31085 Fn3-114 70 rs549841864 0.185 0.194 0.999 N 0.748 0.417 None gnomAD-4.0.0 7.31195E-05 None None None None N None 2.6661E-05 3.33367E-05 None 0 1.69356E-03 None 0 0 1.35615E-05 1.64701E-04 1.12025E-04
E/K 31181 Fn3-115 69 rs1243301263 0.4681 -0.569 0.999 N 0.613 0.408 0.36036328697 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
E/K 31181 Fn3-115 69 rs1243301263 0.4681 -0.569 0.999 N 0.613 0.408 0.36036328697 gnomAD-4.0.0 1.59112E-06 None None None None N None 0 0 None 0 2.77269E-05 None 0 0 0 0 0
E/Q 31181 Fn3-115 69 None 0.267 None 1.0 D 0.632 0.336 0.39619538035 gnomAD-4.0.0 1.59112E-06 None None None None N None 0 0 None 0 0 None 1.88239E-05 0 0 0 0
E/A 31378 Fn3-116 71 None 0.2383 None 0.999 N 0.707 0.502 0.375326005269 gnomAD-4.0.0 1.36893E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7993E-06 0 0
T/A 31579 Fn3-118 74 rs1252165343 0.0773 -1.242 0.005 N 0.137 0.128 0.115124310173 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 0 0
T/A 31579 Fn3-118 74 rs1252165343 0.0773 -1.242 0.005 N 0.137 0.128 0.115124310173 gnomAD-4.0.0 2.73691E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99499E-07 3.47818E-05 0
E/A 31777 Fn3-119 70 rs955172279 0.5821 None 0.999 N 0.704 0.58 0.476754456241 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 2.88018E-04 0 None 0 0 2.94E-05 0 0
E/A 31777 Fn3-119 70 rs955172279 0.5821 None 0.999 N 0.704 0.58 0.476754456241 gnomAD-4.0.0 7.68565E-06 None None None None N None 0 0 None 4.08965E-05 0 None 0 0 9.57153E-06 1.33998E-05 0
E/D 31777 Fn3-119 70 None 0.7207 None 0.999 N 0.467 0.437 0.212008924253 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 31777 Fn3-119 70 rs1203504106 0.6443 -0.786 0.999 N 0.595 0.373 0.436132833422 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.65618E-04
E/K 31777 Fn3-119 70 rs1203504106 0.6443 -0.786 0.999 N 0.595 0.373 0.436132833422 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/K 31777 Fn3-119 70 rs1203504106 0.6443 -0.786 0.999 N 0.595 0.373 0.436132833422 gnomAD-4.0.0 1.85901E-06 None None None None N None 0 1.66689E-05 None 0 0 None 0 0 8.47606E-07 0 1.60113E-05
D/N 31878 Fn3-120 72 rs752844593 0.0995 -1.201 0.001 N 0.311 0.086 0.151104730317 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
D/N 31878 Fn3-120 72 rs752844593 0.0995 -1.201 0.001 N 0.311 0.086 0.151104730317 gnomAD-4.0.0 3.62726E-05 None None None None N None 0 0 None 0 0 None 0 0 4.76846E-05 0 0
K/E 31980 Fn3-121 72 rs1315935878 0.1899 -0.645 0.999 N 0.6 0.405 0.259272394797 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
K/E 31980 Fn3-121 72 rs1315935878 0.1899 -0.645 0.999 N 0.6 0.405 0.259272394797 gnomAD-4.0.0 1.59133E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85851E-06 0 0
K/N 31980 Fn3-121 72 None 0.3575 None 1.0 N 0.735 0.306 0.143124449307 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
M/T 32174 Fn3-122 70 rs749585164 0.1367 -0.958 0.468 N 0.363 0.173 0.471456661759 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 2.79174E-04 None 0 None 0 0 0
M/T 32174 Fn3-122 70 rs749585164 0.1367 -0.958 0.468 N 0.363 0.173 0.471456661759 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/T 32174 Fn3-122 70 rs749585164 0.1367 -0.958 0.468 N 0.363 0.173 0.471456661759 gnomAD-4.0.0 2.47872E-05 None None None None N None 0 0 None 0 7.8017E-04 None 0 0 3.39038E-06 1.09782E-05 0
Q/H 32272 Fn3-123 71 None 0.3287 None 0.949 N 0.601 0.293 0.223146558224 gnomAD-4.0.0 1.59185E-06 None None None None N None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
Q/R 32272 Fn3-123 71 None 0.1475 None 0.722 N 0.567 0.218 0.176091768786 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
E/K 32469 Fn3-124 71 rs1280768790 0.4249 -0.039 0.999 N 0.601 0.421 0.485846224565 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
E/K 32469 Fn3-124 71 rs1280768790 0.4249 -0.039 0.999 N 0.601 0.421 0.485846224565 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/K 32469 Fn3-124 71 rs1280768790 0.4249 -0.039 0.999 N 0.601 0.421 0.485846224565 gnomAD-4.0.0 3.71895E-06 None None None None N None 2.67037E-05 0 None 0 0 None 0 0 3.39074E-06 0 0
E/Q 32569 Fn3-125 71 rs760105762 0.178 -0.373 1.0 N 0.637 0.314 0.398283496042 gnomAD-2.1.1 4.2E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.31E-06 0
E/Q 32569 Fn3-125 71 rs760105762 0.178 -0.373 1.0 N 0.637 0.314 0.398283496042 gnomAD-4.0.0 1.37505E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80484E-06 0 0
E/K 32670 Fn3-126 71 rs1693724796 0.3014 None 0.999 N 0.589 0.419 0.393775345888 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
E/K 32670 Fn3-126 71 rs1693724796 0.3014 None 0.999 N 0.589 0.419 0.393775345888 gnomAD-4.0.0 6.57203E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.06954E-04 0
E/K 32967 Fn3-128 72 rs540132942 0.2614 -0.535 0.999 N 0.607 0.424 0.323886383625 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.67112E-04 None 0 None 0 0 0
E/K 32967 Fn3-128 72 rs540132942 0.2614 -0.535 0.999 N 0.607 0.424 0.323886383625 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 3.85356E-04 None 0 0 0 2.07039E-04 0
E/K 32967 Fn3-128 72 rs540132942 0.2614 -0.535 0.999 N 0.607 0.424 0.323886383625 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
E/K 32967 Fn3-128 72 rs540132942 0.2614 -0.535 0.999 N 0.607 0.424 0.323886383625 gnomAD-4.0.0 7.68559E-06 None None None None N None 0 0 None 0 9.69979E-05 None 0 0 2.39327E-06 1.34009E-05 0
G/D 33361 Fn3-130 72 rs1466606975 0.7452 -1.043 1.0 N 0.86 0.496 0.211220785272 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
G/D 33361 Fn3-130 72 rs1466606975 0.7452 -1.043 1.0 N 0.86 0.496 0.211220785272 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/D 33361 Fn3-130 72 rs1466606975 0.7452 -1.043 1.0 N 0.86 0.496 0.211220785272 gnomAD-4.0.0 1.23987E-06 None None None None N None 1.3354E-05 0 None 0 0 None 0 0 8.47788E-07 0 0
G/S 33361 Fn3-130 72 None 0.19 None 1.0 N 0.748 0.467 0.185906805712 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
E/A 33462 Fn3-131 71 None 0.1783 None 0.999 N 0.687 0.581 0.418718287753 gnomAD-4.0.0 1.5915E-06 None None None None N None 0 0 None 0 2.77316E-05 None 0 0 0 0 0
E/K 33462 Fn3-131 71 rs748104690 0.3911 -0.719 0.999 N 0.601 0.385 0.385417323374 gnomAD-2.1.1 3.22E-05 None None None None N None 0 1.98345E-04 None 0 0 None 6.54E-05 None 0 0 0
E/K 33462 Fn3-131 71 rs748104690 0.3911 -0.719 0.999 N 0.601 0.385 0.385417323374 gnomAD-3.1.2 3.94E-05 None None None None N None 0 3.92619E-04 0 0 0 None 0 0 0 0 0
E/K 33462 Fn3-131 71 rs748104690 0.3911 -0.719 0.999 N 0.601 0.385 0.385417323374 gnomAD-4.0.0 1.61127E-05 None None None None N None 0 3.334E-04 None 0 0 None 0 0 0 6.58834E-05 0
S/N 33757 Fn3-132 69 rs1210718667 0.1774 -0.362 0.342 N 0.407 0.105 0.18274738541 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
S/N 33757 Fn3-132 69 rs1210718667 0.1774 -0.362 0.342 N 0.407 0.105 0.18274738541 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/N 33757 Fn3-132 69 rs1210718667 0.1774 -0.362 0.342 N 0.407 0.105 0.18274738541 gnomAD-4.0.0 6.57099E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46968E-05 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.