Structural position:

  • Domain Type: Fn3
  • Aligned Position: 120
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
P/S 15743 Fn3-1 87 rs757923194 0.2149 -1.364 0.92 D 0.485 0.262 0.238705975628 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
P/S 15743 Fn3-1 87 rs757923194 0.2149 -1.364 0.92 D 0.485 0.262 0.238705975628 gnomAD-4.0.0 1.59334E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86234E-06 0 0
P/A 15844 Fn3-2 87 rs760956511 0.1611 -1.53 1.0 D 0.723 0.416 0.364730456448 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.6835E-04 None 0 None 0 0 0
P/A 15844 Fn3-2 87 rs760956511 0.1611 -1.53 1.0 D 0.723 0.416 0.364730456448 gnomAD-4.0.0 3.18799E-06 None None None None N None 0 0 None 0 5.56452E-05 None 0 0 0 0 0
P/L 15844 Fn3-2 87 rs774050002 0.6017 -0.826 1.0 D 0.826 0.489 0.767917627303 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
P/L 15844 Fn3-2 87 rs774050002 0.6017 -0.826 1.0 D 0.826 0.489 0.767917627303 gnomAD-4.0.0 6.84712E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99969E-07 0 0
P/Q 15844 Fn3-2 87 rs774050002 0.7563 None 1.0 D 0.786 0.479 0.596401026678 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/Q 15844 Fn3-2 87 rs774050002 0.7563 None 1.0 D 0.786 0.479 0.596401026678 gnomAD-4.0.0 3.72129E-06 None None None None N None 0 0 None 0 0 None 0 0 4.24074E-06 0 1.60339E-05
P/L 16140 Fn3-4 86 None 0.2571 None 1.0 D 0.805 0.488 0.656830896108 gnomAD-4.0.0 1.59393E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86421E-06 0 0
P/S 16140 Fn3-4 86 rs1219372837 0.2526 -1.261 1.0 D 0.74 0.444 0.373173300195 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
P/S 16140 Fn3-4 86 rs1219372837 0.2526 -1.261 1.0 D 0.74 0.444 0.373173300195 gnomAD-4.0.0 1.36939E-06 None None None None N None 0 0 None 0 0 None 0 0 9.00059E-07 0 1.65843E-05
P/A 16436 Fn3-6 86 rs527592906 0.0922 -1.584 0.767 D 0.491 0.389 0.361160317528 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 1.95542E-04 None 0 0 0 0 0
P/A 16436 Fn3-6 86 rs527592906 0.0922 -1.584 0.767 D 0.491 0.389 0.361160317528 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
P/A 16436 Fn3-6 86 rs527592906 0.0922 -1.584 0.767 D 0.491 0.389 0.361160317528 gnomAD-4.0.0 6.58311E-06 None None None None N None 0 0 None 0 1.96002E-04 None 0 0 0 0 0
P/L 16436 Fn3-6 86 None 0.3862 None 0.999 D 0.765 0.456 0.750163435421 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/Q 16436 Fn3-6 86 rs1438404271 0.5721 None 1.0 D 0.845 0.467 0.57874735177 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 1.95465E-04 None 0 0 0 0 0
P/Q 16436 Fn3-6 86 rs1438404271 0.5721 None 1.0 D 0.845 0.467 0.57874735177 gnomAD-4.0.0 6.58744E-06 None None None None N None 0 0 None 0 1.95465E-04 None 0 0 0 0 0
P/S 16436 Fn3-6 86 None 0.2182 None 0.998 D 0.739 0.382 0.42828666871 gnomAD-4.0.0 1.59392E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86189E-06 0 0
P/S 16536 Fn3-7 87 None 0.6185 None 0.957 D 0.707 0.387 0.264547087235 gnomAD-4.0.0 6.85199E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00121E-07 0 0
P/H 16636 Fn3-8 86 rs775947694 0.7567 -1.261 1.0 D 0.809 0.524 0.657488933047 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
P/H 16636 Fn3-8 86 rs775947694 0.7567 -1.261 1.0 D 0.809 0.524 0.657488933047 gnomAD-4.0.0 3.42389E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.80316E-05 0
P/R 16636 Fn3-8 86 None 0.8309 None 1.0 D 0.843 0.542 0.637538100058 gnomAD-4.0.0 6.84779E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99899E-07 0 0
Y/N 16736 Fn3-9 86 None 0.8338 None 0.998 N 0.721 0.535 0.676040837911 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/L 16939 Fn3-11 88 rs1321289317 0.6685 -0.83 1.0 D 0.827 0.465 0.746050308143 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.94E-06 0
P/L 16939 Fn3-11 88 rs1321289317 0.6685 -0.83 1.0 D 0.827 0.465 0.746050308143 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
P/S 16939 Fn3-11 88 None 0.4848 None 1.0 D 0.747 0.428 0.386558576397 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/L 17233 Fn3-13 87 rs776803516 0.8203 -0.858 0.987 N 0.78 0.485 0.648041160416 gnomAD-2.1.1 2.43E-05 None None None None N None 0 1.74327E-04 None 0 0 None 0 None 0 0 0
P/L 17233 Fn3-13 87 rs776803516 0.8203 -0.858 0.987 N 0.78 0.485 0.648041160416 gnomAD-4.0.0 3.431E-06 None None None None N None 0 8.96218E-05 None 0 0 None 0 0 9.01933E-07 0 0
P/S 17233 Fn3-13 87 rs761840475 0.7666 -1.332 0.987 N 0.713 0.446 0.361558571881 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
P/S 17233 Fn3-13 87 rs761840475 0.7666 -1.332 0.987 N 0.713 0.446 0.361558571881 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.9478E-04 None 0 0 0 0 0
P/S 17233 Fn3-13 87 rs761840475 0.7666 -1.332 0.987 N 0.713 0.446 0.361558571881 gnomAD-4.0.0 1.86372E-06 None None None None N None 0 0 None 0 4.47227E-05 None 0 0 0 1.10234E-05 0
P/T 17233 Fn3-13 87 rs761840475 0.773 -1.325 0.568 N 0.452 0.437 0.343788945184 gnomAD-2.1.1 8.11E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 8.97E-06 0
P/T 17233 Fn3-13 87 rs761840475 0.773 -1.325 0.568 N 0.452 0.437 0.343788945184 gnomAD-4.0.0 8.91762E-06 None None None None N None 0 0 None 0 0 None 0 0 1.17213E-05 0 0
P/Q 17456 Fn3-14 88 None 0.6858 None 0.998 D 0.654 0.444 0.445910236696 gnomAD-4.0.0 1.5959E-06 None None None None I None 0 0 None 0 2.79658E-05 None 0 0 0 0 0
P/H 17655 Fn3-16 87 None 0.2926 None 1.0 N 0.831 0.427 0.66141328993 gnomAD-4.0.0 6.84523E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99777E-07 0 0
P/R 17655 Fn3-16 87 None 0.3126 None 1.0 N 0.873 0.452 0.667457374772 gnomAD-4.0.0 2.73809E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59911E-06 0 0
P/T 17848 Fn3-17 85 None 0.3334 None 0.993 N 0.74 0.382 0.517047913619 gnomAD-4.0.0 4.79528E-06 None None None None N None 0 0 None 0 0 None 0 0 9.00059E-07 0 9.95388E-05
P/L 17948 Fn3-18 87 None 0.6153 None 1.0 N 0.831 0.521 0.620317764101 gnomAD-4.0.0 6.8575E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01018E-07 0 0
P/Q 17948 Fn3-18 87 rs781513071 0.8119 -1.037 1.0 N 0.796 0.53 0.463328977263 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
P/Q 17948 Fn3-18 87 rs781513071 0.8119 -1.037 1.0 N 0.796 0.53 0.463328977263 gnomAD-4.0.0 2.743E-06 None None None None N None 0 0 None 0 0 None 0 1.73974E-04 2.70305E-06 0 0
P/T 17948 Fn3-18 87 rs2054560822 0.552 None 1.0 N 0.755 0.513 0.476986058749 gnomAD-4.0.0 2.74208E-06 None None None None N None 0 0 None 0 0 None 0 0 3.60319E-06 0 0
E/D 18152 Fn3-19 88 None 0.1 None 0.007 N 0.231 0.03 0.0551355673512 gnomAD-4.0.0 6.90601E-07 None None None None N None 0 0 None 0 0 None 0 0 9.05487E-07 0 0
E/K 18152 Fn3-19 88 None 0.4435 None 0.684 N 0.437 0.222 0.218845423259 gnomAD-4.0.0 1.38499E-06 None None None None N None 0 0 None 0 0 None 0 0 9.07342E-07 0 1.67949E-05
P/L 18257 Fn3-20 92 rs1429008245 0.3828 None 0.998 N 0.753 0.363 0.406806705197 gnomAD-4.0.0 1.59652E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.03435E-05
P/A 18360 Fn3-21 89 None 0.085 None 1.0 N 0.72 0.374 0.339074221408 gnomAD-4.0.0 1.59321E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86156E-06 0 0
P/L 18360 Fn3-21 89 rs192788942 0.2536 -0.788 1.0 N 0.819 0.477 None gnomAD-2.1.1 1.6111E-04 None None None None N None 1.6973E-03 1.13398E-04 None 0 0 None 0 None 0 0 0
P/L 18360 Fn3-21 89 rs192788942 0.2536 -0.788 1.0 N 0.819 0.477 None gnomAD-3.1.2 4.86925E-04 None None None None N None 1.7632E-03 6.57E-05 0 0 0 None 0 0 0 0 0
P/L 18360 Fn3-21 89 rs192788942 0.2536 -0.788 1.0 N 0.819 0.477 None 1000 genomes 7.98722E-04 None None None None N None 3E-03 0 None None 0 0 None None None 0 None
P/L 18360 Fn3-21 89 rs192788942 0.2536 -0.788 1.0 N 0.819 0.477 None gnomAD-4.0.0 8.86623E-05 None None None None N None 1.70812E-03 8.34474E-05 None 0 0 None 0 0 3.3918E-06 0 9.60953E-05
P/S 18670 Fn3-23 92 rs777752824 0.5631 -1.706 1.0 N 0.765 0.434 0.408307896497 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
P/S 18670 Fn3-23 92 rs777752824 0.5631 -1.706 1.0 N 0.765 0.434 0.408307896497 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/S 18670 Fn3-23 92 rs777752824 0.5631 -1.706 1.0 N 0.765 0.434 0.408307896497 gnomAD-4.0.0 5.07557E-06 None None None None N None 0 0 None 0 0 None 0 0 6.02527E-06 0 0
P/H 18870 Fn3-24 87 rs755909878 0.5286 -1.529 1.0 N 0.824 0.494 0.627496920012 gnomAD-2.1.1 1.74E-05 None None None None N None 0 0 None 0 0 None 1.40154E-04 None 0 0 2.58799E-04
P/H 18870 Fn3-24 87 rs755909878 0.5286 -1.529 1.0 N 0.824 0.494 0.627496920012 gnomAD-4.0.0 5.70386E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.13748E-05 0
P/L 18870 Fn3-24 87 rs755909878 0.5524 -0.753 1.0 N 0.829 0.488 0.731689507483 gnomAD-2.1.1 5.8E-06 None None None None N None 0 5.12E-05 None 0 0 None 0 None 0 0 0
P/L 18870 Fn3-24 87 rs755909878 0.5524 -0.753 1.0 N 0.829 0.488 0.731689507483 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.78011E-04
P/L 18870 Fn3-24 87 rs755909878 0.5524 -0.753 1.0 N 0.829 0.488 0.731689507483 gnomAD-4.0.0 2.94974E-06 None None None None N None 0 2.36686E-05 None 0 0 None 0 0 0 0 3.25182E-05
A/V 18974 Fn3-25 91 rs1336627311 0.2533 -0.322 0.946 N 0.444 0.346 0.257292322809 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
A/V 18974 Fn3-25 91 rs1336627311 0.2533 -0.322 0.946 N 0.444 0.346 0.257292322809 gnomAD-4.0.0 1.59207E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85992E-06 0 0
P/R 19074 Fn3-26 87 None 0.6865 None 0.999 N 0.853 0.434 0.604919980721 gnomAD-4.0.0 1.59233E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8599E-06 0 0
F/L 19269 Fn3-27 87 rs1214774748 0.9615 None 0.698 N 0.656 0.348 0.304435445954 gnomAD-4.0.0 3.43113E-06 None None None None I None 0 0 None 0 0 None 0 0 6.15184E-06 0 0
F/S 19269 Fn3-27 87 None 0.7657 None 0.942 N 0.756 0.303 0.691616392624 gnomAD-4.0.0 3.4326E-06 None None None None I None 0 0 None 0 0 None 0 0 6.15362E-06 0 0
P/A 19370 Fn3-28 87 None 0.4129 None 1.0 N 0.787 0.424 0.362758974969 gnomAD-4.0.0 1.37864E-06 None None None None N None 0 0 None 0 0 None 0 0 1.8084E-06 0 0
P/T 19370 Fn3-28 87 rs890232785 0.8225 None 1.0 N 0.829 0.445 None gnomAD-4.0.0 6.8932E-07 None None None None N None 3.02645E-05 0 None 0 0 None 0 0 0 0 0
P/H 19565 Fn3-29 87 None 0.5205 None 1.0 N 0.793 0.445 0.546174653742 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
P/L 19565 Fn3-29 87 rs878880222 0.5072 -0.724 1.0 N 0.812 0.485 None gnomAD-2.1.1 3.19E-05 None None None None I None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
P/L 19565 Fn3-29 87 rs878880222 0.5072 -0.724 1.0 N 0.812 0.485 None gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
P/L 19565 Fn3-29 87 rs878880222 0.5072 -0.724 1.0 N 0.812 0.485 None gnomAD-4.0.0 1.97306E-05 None None None None I None 7.24323E-05 0 None 0 0 None 0 0 0 0 0
F/L 19962 Fn3-32 86 rs2050323196 0.9338 None 0.64 N 0.501 0.386 0.27132560031 gnomAD-4.0.0 6.16102E-06 None None None None N None 0 0 None 0 0 None 0 0 8.09722E-06 0 0
F/S 19962 Fn3-32 86 rs878939618 0.5977 None 0.984 N 0.626 0.325 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
F/S 19962 Fn3-32 86 rs878939618 0.5977 None 0.984 N 0.626 0.325 None gnomAD-4.0.0 1.31491E-05 None None None None N None 4.82509E-05 0 None 0 0 None 0 0 0 0 0
P/L 20061 Fn3-33 85 None 0.697 None 1.0 N 0.777 0.482 0.745533171595 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 20653 Fn3-37 85 rs1553641323 0.2562 None 0.669 N 0.529 0.123 None gnomAD-4.0.0 2.73722E-06 None None None None I None 0 0 None 0 5.0421E-05 None 0 0 1.79916E-06 0 0
T/S 20653 Fn3-37 85 None 0.1568 None 0.136 N 0.272 0.085 0.137902524267 gnomAD-4.0.0 6.84304E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99582E-07 0 0
P/R 21049 Fn3-40 87 rs1559560525 0.7905 None 0.946 N 0.863 0.497 0.447311733946 gnomAD-2.1.1 5.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.06E-05 0
P/R 21049 Fn3-40 87 rs1559560525 0.7905 None 0.946 N 0.863 0.497 0.447311733946 gnomAD-4.0.0 2.86209E-06 None None None None I None 0 0 None 0 0 None 0 0 3.69436E-06 0 0
P/S 21049 Fn3-40 87 None 0.2713 None 0.898 N 0.741 0.371 0.279776271856 gnomAD-4.0.0 1.77046E-06 None None None None I None 0 0 None 0 2.80962E-05 None 0 0 0 0 0
P/S 21156 Fn3-41 93 None 0.2812 None 0.999 N 0.673 0.4 0.286465849087 gnomAD-4.0.0 1.60695E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44672E-05 0
P/S 21351 Fn3-42 86 rs1421350004 0.2316 -1.0 1.0 N 0.757 0.381 0.346992582518 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
P/S 21351 Fn3-42 86 rs1421350004 0.2316 -1.0 1.0 N 0.757 0.381 0.346992582518 gnomAD-4.0.0 1.27384E-05 None None None None N None 0 0 None 0 0 None 0 0 1.71646E-05 0 6.0529E-05
P/L 21645 Fn3-44 87 None 0.5455 None 0.993 N 0.744 0.459 None gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/S 21645 Fn3-44 87 rs1553632774 0.2449 None 0.987 N 0.682 0.402 0.324986149311 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/S 21645 Fn3-44 87 rs1553632774 0.2449 None 0.987 N 0.682 0.402 0.324986149311 gnomAD-4.0.0 2.03023E-06 None None None None I None 0 0 None 0 0 None 0 0 1.205E-06 0 3.40252E-05
P/L 21745 Fn3-45 87 rs2048457148 0.4043 None 1.0 N 0.827 0.486 0.619659205309 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/L 21745 Fn3-45 87 rs2048457148 0.4043 None 1.0 N 0.827 0.486 0.619659205309 gnomAD-4.0.0 3.04538E-06 None None None None N None 0 0 None 0 0 None 0 0 3.61503E-06 0 0
P/T 21745 Fn3-45 87 rs777182534 0.3878 -1.554 1.0 N 0.763 0.426 0.510113526977 gnomAD-2.1.1 8.23E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.83E-05 0
P/T 21745 Fn3-45 87 rs777182534 0.3878 -1.554 1.0 N 0.763 0.426 0.510113526977 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
P/T 21745 Fn3-45 87 rs777182534 0.3878 -1.554 1.0 N 0.763 0.426 0.510113526977 gnomAD-4.0.0 1.81222E-05 None None None None N None 0 0 None 0 0 None 0 0 2.3921E-05 0 1.6165E-05
P/L 21845 Fn3-46 89 rs201662134 0.5222 -0.703 0.999 N 0.763 0.433 None gnomAD-2.1.1 4.78022E-04 None None None None N None 0 2.84738E-04 None 9.54236E-03 0 None 3.3E-05 None 0 1.57107E-04 5.67054E-04
P/L 21845 Fn3-46 89 rs201662134 0.5222 -0.703 0.999 N 0.763 0.433 None gnomAD-3.1.2 2.63026E-04 None None None None N None 0 6.55E-05 0 8.64055E-03 0 None 0 0 1.32369E-04 0 0
P/L 21845 Fn3-46 89 rs201662134 0.5222 -0.703 0.999 N 0.763 0.433 None gnomAD-4.0.0 2.5878E-04 None None None None N None 1.33383E-05 2.33871E-04 None 9.65186E-03 0 None 0 8.364E-04 6.10879E-05 1.10249E-05 6.25441E-04
P/T 22243 Fn3-49 88 None 0.5323 None 1.0 N 0.751 0.466 0.561180645722 gnomAD-4.0.0 4.79862E-06 None None None None I None 0 0 None 0 0 None 5.66316E-05 0 0 0 0
P/A 22439 Fn3-50 86 rs987188592 0.094 None 0.9 N 0.531 0.241 0.313818047136 gnomAD-4.0.0 1.59262E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86036E-06 0 0
P/Q 22829 Fn3-53 87 rs747495409 0.6053 -1.027 1.0 N 0.777 0.452 0.427254322456 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14732E-04 0 None 0 0 None 0 None 0 0 0
P/Q 22829 Fn3-53 87 rs747495409 0.6053 -1.027 1.0 N 0.777 0.452 0.427254322456 gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
P/Q 22829 Fn3-53 87 rs747495409 0.6053 -1.027 1.0 N 0.777 0.452 0.427254322456 gnomAD-4.0.0 1.97272E-05 None None None None I None 7.24113E-05 0 None 0 0 None 0 0 0 0 0
P/S 22928 Fn3-54 88 rs1206552803 0.2747 -1.623 1.0 N 0.746 0.365 0.366848117066 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
P/S 22928 Fn3-54 88 rs1206552803 0.2747 -1.623 1.0 N 0.746 0.365 0.366848117066 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/S 22928 Fn3-54 88 rs1206552803 0.2747 -1.623 1.0 N 0.746 0.365 0.366848117066 gnomAD-4.0.0 2.566E-06 None None None None N None 0 0 None 0 0 None 0 0 4.79063E-06 0 0
P/S 23125 Fn3-55 86 None 0.1585 None 0.159 N 0.293 0.37 0.260735089382 gnomAD-4.0.0 1.59197E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43308E-05 0
P/S 23225 Fn3-56 87 None 0.162 None 0.997 N 0.745 0.371 0.240491677333 gnomAD-4.0.0 2.40064E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 1.3125E-06 0 0
P/S 23327 Fn3-57 88 None 0.1948 None 1.0 N 0.726 0.375 0.339316883193 gnomAD-4.0.0 3.18491E-06 None None None None I None 1.13225E-04 0 None 0 0 None 0 0 0 0 0
P/L 23520 Fn3-58 86 rs763169614 0.4417 -0.755 0.997 D 0.762 0.418 0.615473259424 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.67E-05 0
P/L 23520 Fn3-58 86 rs763169614 0.4417 -0.755 0.997 D 0.762 0.418 0.615473259424 gnomAD-4.0.0 1.98434E-05 None None None None I None 0 0 None 0 0 None 0 0 2.60869E-05 0 0
P/R 23520 Fn3-58 86 rs763169614 0.7757 -0.306 1.0 D 0.845 0.458 0.486779940545 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
P/R 23520 Fn3-58 86 rs763169614 0.7757 -0.306 1.0 D 0.845 0.458 0.486779940545 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/R 23520 Fn3-58 86 rs763169614 0.7757 -0.306 1.0 D 0.845 0.458 0.486779940545 gnomAD-4.0.0 6.57912E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47089E-05 0 0
P/T 23520 Fn3-58 86 rs1296805014 0.3871 -1.036 0.993 N 0.795 0.335 0.39843156188 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
P/T 23520 Fn3-58 86 rs1296805014 0.3871 -1.036 0.993 N 0.795 0.335 0.39843156188 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/T 23520 Fn3-58 86 rs1296805014 0.3871 -1.036 0.993 N 0.795 0.335 0.39843156188 gnomAD-4.0.0 6.57756E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47076E-05 0 0
P/H 23616 Fn3-59 85 None 0.4686 None 1.0 D 0.771 0.457 0.633664262589 gnomAD-4.0.0 1.59222E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8594E-06 0 0
G/D 23812 Fn3-60 87 rs1363526137 0.5017 -1.156 0.029 N 0.565 0.171 0.163833314356 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
G/D 23812 Fn3-60 87 rs1363526137 0.5017 -1.156 0.029 N 0.565 0.171 0.163833314356 gnomAD-4.0.0 4.10634E-06 None None None None N None 2.98918E-05 0 None 0 0 None 0 0 4.49807E-06 0 0
P/A 23912 Fn3-61 87 rs773568399 0.0678 None 0.006 N 0.349 0.152 0.130388298395 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
P/A 23912 Fn3-61 87 rs773568399 0.0678 None 0.006 N 0.349 0.152 0.130388298395 gnomAD-4.0.0 1.23964E-06 None None None None I None 0 1.66761E-05 None 0 0 None 0 0 8.47732E-07 0 0
P/T 23912 Fn3-61 87 None 0.1734 -1.195 0.125 N 0.418 0.193 None gnomAD-2.1.1 1.43E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.35E-05 1.40687E-04
P/T 23912 Fn3-61 87 None 0.1734 -1.195 0.125 N 0.418 0.193 None gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 9.42E-05 0 1.47E-05 0 0
P/T 23912 Fn3-61 87 None 0.1734 -1.195 0.125 N 0.418 0.193 None gnomAD-4.0.0 1.0537E-05 None None None None I None 0 0 None 0 0 None 1.5626E-05 0 1.2716E-05 0 1.60143E-05
P/S 24011 Fn3-62 88 rs746055019 0.2874 -1.402 1.0 N 0.758 0.401 None gnomAD-2.1.1 1.79E-05 None None None None N None 0 0 None 0 1.54289E-04 None 0 None 0 1.57E-05 0
P/S 24011 Fn3-62 88 rs746055019 0.2874 -1.402 1.0 N 0.758 0.401 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 1.93949E-04 None 0 0 2.94E-05 0 0
P/S 24011 Fn3-62 88 rs746055019 0.2874 -1.402 1.0 N 0.758 0.401 None gnomAD-4.0.0 7.4376E-06 None None None None N None 0 0 None 0 4.46269E-05 None 0 0 8.47719E-06 0 0
P/A 24308 Fn3-64 87 rs1334601287 0.0676 -1.254 0.955 N 0.622 0.341 0.227934060464 gnomAD-2.1.1 4.1E-06 None None None None N None 0 2.93E-05 None 0 0 None 0 None 0 0 0
P/A 24308 Fn3-64 87 rs1334601287 0.0676 -1.254 0.955 N 0.622 0.341 0.227934060464 gnomAD-4.0.0 1.60722E-06 None None None None N None 0 2.30394E-05 None 0 0 None 0 0 0 0 0
P/R 24308 Fn3-64 87 rs1553608507 0.492 None 0.993 D 0.857 0.481 0.619820317479 gnomAD-4.0.0 1.37444E-06 None None None None N None 0 0 None 0 0 None 0 1.7452E-04 9.02646E-07 0 0
P/L 24410 Fn3-65 88 rs368510432 0.3508 None 0.993 N 0.774 0.472 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/L 24410 Fn3-65 88 rs368510432 0.3508 None 0.993 N 0.774 0.472 None gnomAD-4.0.0 2.56358E-06 None None None None I None 0 0 None 0 0 None 0 0 4.78822E-06 0 0
P/S 24410 Fn3-65 88 None 0.2418 None 0.987 N 0.698 0.351 0.231231049324 gnomAD-4.0.0 1.5922E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85958E-06 0 0
P/S 24604 Fn3-66 86 None 0.5425 None 0.988 N 0.697 0.427 0.340510301474 gnomAD-4.0.0 3.19777E-06 None None None None I None 0 0 None 0 0 None 0 0 5.75649E-06 0 0
Y/H 24894 Fn3-68 87 None 0.2356 None 0.954 N 0.515 0.092 0.273503213844 gnomAD-4.0.0 3.18406E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71889E-06 0 0
P/L 24994 Fn3-69 87 rs531281558 0.1114 -0.552 0.476 N 0.432 0.273 None gnomAD-2.1.1 2.42E-05 None None None None I None 0 1.44978E-04 None 0 0 None 3.27E-05 None 0 0 0
P/L 24994 Fn3-69 87 rs531281558 0.1114 -0.552 0.476 N 0.432 0.273 None gnomAD-3.1.2 1.97E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 2.07469E-04 0
P/L 24994 Fn3-69 87 rs531281558 0.1114 -0.552 0.476 N 0.432 0.273 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
P/L 24994 Fn3-69 87 rs531281558 0.1114 -0.552 0.476 N 0.432 0.273 None gnomAD-4.0.0 1.4876E-05 None None None None I None 1.33362E-05 1.16698E-04 None 0 0 None 0 0 1.01732E-05 1.0981E-05 4.80369E-05
P/T 24994 Fn3-69 87 rs1416288780 0.0912 -0.873 0.01 N 0.263 0.124 0.24896430686 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.49E-05 0
P/T 24994 Fn3-69 87 rs1416288780 0.0912 -0.873 0.01 N 0.263 0.124 0.24896430686 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/T 24994 Fn3-69 87 rs1416288780 0.0912 -0.873 0.01 N 0.263 0.124 0.24896430686 gnomAD-4.0.0 6.57851E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47089E-05 0 0
P/A 25093 Fn3-70 88 rs748359400 0.1391 None 0.919 N 0.578 0.252 0.159798565429 gnomAD-4.0.0 6.84296E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99564E-07 0 0
P/S 25093 Fn3-70 88 rs748359400 0.4416 -1.324 0.414 N 0.427 0.316 0.143124449307 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
P/S 25093 Fn3-70 88 rs748359400 0.4416 -1.324 0.414 N 0.427 0.316 0.143124449307 gnomAD-4.0.0 1.30016E-05 None None None None N None 0 0 None 0 0 None 0 0 1.61921E-05 1.15939E-05 0
P/L 25290 Fn3-71 87 None 0.4137 None 1.0 N 0.806 0.466 0.630881660512 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/L 25390 Fn3-72 87 rs775467614 0.1862 -0.701 0.976 N 0.78 0.501 0.551467209619 gnomAD-2.1.1 8.1E-06 None None None None I None 0 0 None 0 5.61E-05 None 3.28E-05 None 0 0 0
P/L 25390 Fn3-72 87 rs775467614 0.1862 -0.701 0.976 N 0.78 0.501 0.551467209619 gnomAD-4.0.0 3.19006E-06 None None None None I None 0 0 None 0 2.78118E-05 None 0 0 0 1.43546E-05 0
P/S 25390 Fn3-72 87 rs878948198 0.2142 -1.078 0.976 N 0.696 0.418 None gnomAD-2.1.1 1.21E-05 None None None None I None 0 2.91E-05 None 0 0 None 0 None 0 1.79E-05 0
P/S 25390 Fn3-72 87 rs878948198 0.2142 -1.078 0.976 N 0.696 0.418 None gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
P/S 25390 Fn3-72 87 rs878948198 0.2142 -1.078 0.976 N 0.696 0.418 None gnomAD-4.0.0 5.08679E-05 None None None None I None 0 0 None 0 0 None 0 0 6.70153E-05 0 4.80846E-05
P/T 25390 Fn3-72 87 None 0.2069 None 0.988 N 0.704 0.449 0.417081434665 gnomAD-4.0.0 2.05472E-06 None None None None I None 0 0 None 0 0 None 0 0 2.70057E-06 0 0
H/L 25492 Fn3-73 88 rs766094077 0.2086 0.799 0.684 N 0.594 0.188 0.423360453849 gnomAD-2.1.1 4.07E-06 None None None None I None 0 0 None 0 0 None 0 None 4.68E-05 0 0
H/L 25492 Fn3-73 88 rs766094077 0.2086 0.799 0.684 N 0.594 0.188 0.423360453849 gnomAD-4.0.0 1.59436E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86234E-06 0 0
H/P 25492 Fn3-73 88 rs766094077 0.0774 None 0.007 N 0.503 0.267 0.139678290688 gnomAD-4.0.0 1.59436E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86234E-06 0 0
H/Q 25492 Fn3-73 88 None 0.2553 None 0.939 N 0.558 0.198 0.128392430309 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
P/H 26175 Fn3-78 88 None 0.8045 None 1.0 N 0.805 0.515 0.428976297845 gnomAD-4.0.0 6.1657E-06 None None None None N None 0 0 None 3.83436E-05 0 None 0 0 7.20327E-06 0 0
P/L 26175 Fn3-78 88 rs759843428 0.6623 -0.759 1.0 D 0.825 0.517 0.588350616613 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 1.0016E-04 0 None 0 None 0 0 0
P/L 26175 Fn3-78 88 rs759843428 0.6623 -0.759 1.0 D 0.825 0.517 0.588350616613 gnomAD-4.0.0 6.85078E-07 None None None None N None 0 0 None 3.83436E-05 0 None 0 0 0 0 0
P/S 26175 Fn3-78 88 None 0.5728 None 1.0 N 0.746 0.445 0.308278614506 gnomAD-4.0.0 1.59572E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86715E-06 0 0
A/D 26574 Fn3-81 88 None 0.2556 None 0.497 N 0.63 0.319 0.410469974859 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
P/A 26864 Fn3-83 85 rs1296708710 0.1343 -1.74 1.0 N 0.741 0.424 0.339316883193 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
P/A 26864 Fn3-83 85 rs1296708710 0.1343 -1.74 1.0 N 0.741 0.424 0.339316883193 gnomAD-4.0.0 1.5917E-06 None None None None N None 0 2.28666E-05 None 0 0 None 0 0 0 0 0
P/A 27158 Fn3-85 87 rs200771189 0.0574 -1.142 None N 0.249 0.098 None gnomAD-2.1.1 4.11328E-04 None None None None I None 8.27E-05 1.98413E-04 None 0 0 None 0 None 4.80154E-04 6.96859E-04 7.03631E-04
P/A 27158 Fn3-85 87 rs200771189 0.0574 -1.142 None N 0.249 0.098 None gnomAD-3.1.2 5.7206E-04 None None None None I None 2.17213E-04 1.44262E-03 0 0 0 None 1.88679E-04 0 7.94048E-04 0 0
P/A 27158 Fn3-85 87 rs200771189 0.0574 -1.142 None N 0.249 0.098 None gnomAD-4.0.0 5.18792E-04 None None None None I None 1.73602E-04 5.00501E-04 None 0 0 None 5.31499E-04 0 6.30666E-04 0 2.56246E-04
P/R 27158 Fn3-85 87 rs762635284 0.2908 -0.245 0.055 N 0.603 0.305 0.351830644314 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.61E-05 None 0 None 0 0 0
P/R 27158 Fn3-85 87 rs762635284 0.2908 -0.245 0.055 N 0.603 0.305 0.351830644314 gnomAD-4.0.0 1.59196E-06 None None None None I None 0 0 None 0 2.78133E-05 None 0 0 0 0 0
P/L 27257 Fn3-86 88 None 0.5985 None 1.0 D 0.829 0.451 0.763603987931 gnomAD-4.0.0 1.59149E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85835E-06 0 0
P/T 27455 Fn3-87 87 None 0.2605 None 0.709 D 0.637 0.251 0.292787519742 gnomAD-4.0.0 1.59138E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85845E-06 0 0
P/A 27555 Fn3-88 87 None 0.0967 None 0.338 N 0.558 0.202 0.194818534648 gnomAD-4.0.0 6.84248E-07 None None None None I None 2.98793E-05 0 None 0 0 None 0 0 0 0 0
P/L 27555 Fn3-88 87 rs1704434305 0.134 None 0.338 N 0.651 0.298 0.570825458115 gnomAD-4.0.0 1.59147E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8585E-06 0 0
P/S 27555 Fn3-88 87 rs1704435200 0.1968 None 0.013 N 0.37 0.256 0.193865811164 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 1.8843E-04 0 0 0 0
P/S 27555 Fn3-88 87 rs1704435200 0.1968 None 0.013 N 0.37 0.256 0.193865811164 gnomAD-4.0.0 3.09888E-06 None None None None I None 0 0 None 0 0 None 7.81104E-05 0 0 0 0
P/T 27657 Fn3-89 88 None 0.2478 None 0.961 N 0.459 0.296 0.387042434762 gnomAD-4.0.0 1.59139E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85869E-06 0 0
Y/C 28140 Fn3-92 86 None 0.104 None 0.994 N 0.566 0.312 0.420939154896 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
Y/H 28140 Fn3-92 86 rs1703729439 0.1931 None 0.007 N 0.355 0.121 0.214338557667 gnomAD-4.0.0 1.59848E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87289E-06 0 0
C/Y 28240 Fn3-93 87 rs1703613576 0.3971 None 0.99 N 0.753 0.346 0.552326942858 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
C/Y 28240 Fn3-93 87 rs1703613576 0.3971 None 0.99 N 0.753 0.346 0.552326942858 gnomAD-4.0.0 6.57281E-06 None None None None I None 2.41243E-05 0 None 0 0 None 0 0 0 0 0
P/T 28536 Fn3-95 87 rs1703229481 0.134 None 0.124 N 0.481 0.141 0.134241683229 gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
P/T 28536 Fn3-95 87 rs1703229481 0.134 None 0.124 N 0.481 0.141 0.134241683229 gnomAD-4.0.0 3.84685E-06 None None None None I None 3.38662E-05 0 None 0 0 None 0 0 2.39412E-06 0 0
P/R 28636 Fn3-96 87 rs879238812 0.4829 -0.561 1.0 D 0.854 0.485 None gnomAD-2.1.1 7.14E-06 None None None None I None 8.27E-05 0 None 0 0 None 0 None 0 0 0
P/R 28636 Fn3-96 87 rs879238812 0.4829 -0.561 1.0 D 0.854 0.485 None gnomAD-3.1.2 1.31E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
P/R 28636 Fn3-96 87 rs879238812 0.4829 -0.561 1.0 D 0.854 0.485 None gnomAD-4.0.0 3.8435E-06 None None None None I None 5.07528E-05 0 None 0 0 None 0 0 0 0 0
P/L 28736 Fn3-97 86 rs1457797876 0.2619 -0.776 1.0 N 0.821 0.453 0.701836728922 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
P/L 28736 Fn3-97 86 rs1457797876 0.2619 -0.776 1.0 N 0.821 0.453 0.701836728922 gnomAD-4.0.0 2.73703E-06 None None None None I None 0 2.23644E-05 None 0 0 None 0 0 2.69844E-06 0 0
P/S 28930 Fn3-98 86 rs758656233 0.2037 None 0.979 N 0.396 0.229 0.28058544554 gnomAD-4.0.0 1.37241E-06 None None None None I None 0 0 None 0 0 None 0 0 1.80292E-06 0 0
P/L 29026 Fn3-99 85 rs876658090 0.5303 -0.515 0.999 N 0.658 0.316 0.599992621797 gnomAD-2.1.1 3.18E-05 None None None None I None 0 1.17924E-03 None 0 0 None 0 None 0 0 0
P/L 29026 Fn3-99 85 rs876658090 0.5303 -0.515 0.999 N 0.658 0.316 0.599992621797 gnomAD-3.1.2 1.97E-05 None None None None I None 2.41E-05 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
P/L 29026 Fn3-99 85 rs876658090 0.5303 -0.515 0.999 N 0.658 0.316 0.599992621797 gnomAD-4.0.0 3.71874E-06 None None None None I None 1.33494E-05 1.66756E-05 None 0 0 None 0 0 3.39055E-06 0 0
H/P 29223 Fn3-100 87 rs369880812 0.113 None 1.0 N 0.699 0.442 0.368743488249 gnomAD-4.0.0 6.84168E-07 None None None None N None 0 2.23614E-05 None 0 0 None 0 0 0 0 0
H/R 29223 Fn3-100 87 rs369880812 0.4976 -1.118 1.0 N 0.61 0.348 0.313518423057 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
H/R 29223 Fn3-100 87 rs369880812 0.4976 -1.118 1.0 N 0.61 0.348 0.313518423057 gnomAD-4.0.0 6.15751E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.04358E-04 0
H/Y 29223 Fn3-100 87 None 0.1226 None 0.999 N 0.572 0.384 0.307648195649 gnomAD-4.0.0 1.36835E-06 None None None None N None 0 0 None 3.82673E-05 0 None 0 0 8.99426E-07 0 0
P/S 29323 Fn3-101 87 rs1371741615 0.2742 -1.452 0.012 N 0.396 0.141 0.200317383148 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
P/S 29323 Fn3-101 87 rs1371741615 0.2742 -1.452 0.012 N 0.396 0.141 0.200317383148 gnomAD-4.0.0 1.59113E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85768E-06 0 0
P/A 29422 Fn3-102 88 rs1414305688 0.1808 -1.484 1.0 N 0.726 0.378 0.315609569513 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
P/A 29422 Fn3-102 88 rs1414305688 0.1808 -1.484 1.0 N 0.726 0.378 0.315609569513 gnomAD-4.0.0 3.18278E-06 None None None None I None 0 0 None 0 0 None 0 4.82393E-04 0 0 0
P/L 29422 Fn3-102 88 rs753410959 0.7153 -0.539 1.0 N 0.821 0.443 0.626407189966 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
P/L 29422 Fn3-102 88 rs753410959 0.7153 -0.539 1.0 N 0.821 0.443 0.626407189966 gnomAD-3.1.2 1.31E-05 None None None None I None 0 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
P/L 29422 Fn3-102 88 rs753410959 0.7153 -0.539 1.0 N 0.821 0.443 0.626407189966 gnomAD-4.0.0 8.67591E-06 None None None None I None 0 1.66694E-05 None 0 0 None 0 0 9.32344E-06 2.19573E-05 0
P/L 29619 Fn3-103 87 rs1042897248 0.3097 None 0.331 N 0.691 0.46 0.489589578638 gnomAD-4.0.0 6.84609E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16052E-05 0
P/A 29821 Fn3-105 88 rs1469989307 0.0932 None 0.134 N 0.283 0.193 0.149567049428 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 2.88018E-04 0 None 0 0 0 0 0
P/A 29821 Fn3-105 88 rs1469989307 0.0932 None 0.134 N 0.283 0.193 0.149567049428 gnomAD-4.0.0 6.57177E-06 None None None None I None 0 0 None 2.88018E-04 0 None 0 0 0 0 0
P/S 29821 Fn3-105 88 None 0.1879 None 0.31 N 0.299 0.261 0.16115917748 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/H 30018 Fn3-106 86 None 0.5268 None 1.0 D 0.704 0.397 0.692330729506 gnomAD-4.0.0 6.84209E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99444E-07 0 0
P/L 30018 Fn3-106 86 None 0.376 None 0.997 D 0.684 0.411 0.7666748136 gnomAD-4.0.0 6.84209E-07 None None None None I None 2.98686E-05 0 None 0 0 None 0 0 0 0 0
P/R 30018 Fn3-106 86 rs772408269 0.6346 -0.317 0.998 N 0.695 0.372 0.628968807243 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
P/R 30018 Fn3-106 86 rs772408269 0.6346 -0.317 0.998 N 0.695 0.372 0.628968807243 gnomAD-4.0.0 4.78946E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29611E-06 0 0
P/S 30018 Fn3-106 86 rs775796355 0.2683 None 0.978 N 0.573 0.328 0.31411915649 gnomAD-4.0.0 1.36841E-06 None None None None I None 0 0 None 0 0 None 1.8735E-05 0 8.99442E-07 0 0
P/T 30018 Fn3-106 86 rs775796355 0.2958 -1.044 0.733 D 0.437 0.387 0.437741185291 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
P/T 30018 Fn3-106 86 rs775796355 0.2958 -1.044 0.733 D 0.437 0.387 0.437741185291 gnomAD-4.0.0 4.10524E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59777E-06 2.31873E-05 0
P/S 30114 Fn3-107 85 rs745525849 0.0975 -1.273 None N 0.255 0.2 0.0716867268079 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
P/S 30114 Fn3-107 85 rs745525849 0.0975 -1.273 None N 0.255 0.2 0.0716867268079 gnomAD-4.0.0 1.59133E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
P/L 30310 Fn3-108 87 None 0.4751 None 0.89 N 0.685 0.444 0.677296958874 gnomAD-4.0.0 1.59631E-06 None None None None I None 0 0 None 0 0 None 0 0 2.87219E-06 0 0
P/L 30410 Fn3-109 87 None 0.1591 None 0.454 N 0.523 0.303 0.524792858863 gnomAD-4.0.0 1.61041E-06 None None None None N None 0 0 None 0 0 None 0 0 2.89884E-06 0 0
P/L 30508 Fn3-110 87 rs1265539582 0.7397 -0.61 1.0 N 0.824 0.468 0.749380735757 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
P/L 30508 Fn3-110 87 rs1265539582 0.7397 -0.61 1.0 N 0.824 0.468 0.749380735757 gnomAD-4.0.0 1.59248E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43336E-05 0
P/S 30508 Fn3-110 87 None 0.5943 None 1.0 N 0.76 0.425 0.36256342048 gnomAD-4.0.0 1.59244E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.027E-05
P/T 31101 Fn3-114 86 None 0.1736 None 0.999 D 0.68 0.38 0.503002171853 gnomAD-4.0.0 2.05257E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79889E-06 0 1.65651E-05
A/D 31494 Fn3-117 87 rs748231785 0.9351 -1.644 0.997 N 0.739 0.472 0.575848135552 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
A/D 31494 Fn3-117 87 rs748231785 0.9351 -1.644 0.997 N 0.739 0.472 0.575848135552 gnomAD-4.0.0 3.18423E-06 None None None None I None 0 4.5731E-05 None 0 0 None 0 0 0 0 0
A/T 31494 Fn3-117 87 rs769948504 0.36 -1.252 0.977 N 0.608 0.184 0.37097340754 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
A/T 31494 Fn3-117 87 rs769948504 0.36 -1.252 0.977 N 0.608 0.184 0.37097340754 gnomAD-4.0.0 5.4749E-06 None None None None I None 0 0 None 0 0 None 0 0 0 8.11726E-05 1.65684E-05
G/A 31596 Fn3-118 91 None 0.0886 None 0.103 N 0.385 0.171 0.149567049428 gnomAD-4.0.0 6.84407E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99711E-07 0 0
G/E 31596 Fn3-118 91 None 0.5002 None 0.968 N 0.586 0.327 0.338592109245 gnomAD-4.0.0 1.36881E-06 None None None None I None 0 0 None 0 2.52156E-05 None 0 0 8.99711E-07 0 0
P/A 31793 Fn3-119 86 None 0.0615 None 0.996 N 0.563 0.404 0.326074293725 gnomAD-4.0.0 1.36846E-06 None None None None N None 0 0 None 0 0 None 0 0 1.799E-06 0 0
P/L 31793 Fn3-119 86 rs1696849077 0.2731 None 0.998 D 0.733 0.476 0.617224619168 gnomAD-4.0.0 1.44039E-05 None None None None N None 0 0 None 0 0 None 0 0 1.575E-05 0 0
P/T 31793 Fn3-119 86 rs1466581888 0.1696 -1.591 0.999 N 0.703 0.386 0.411799315854 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
P/T 31793 Fn3-119 86 rs1466581888 0.1696 -1.591 0.999 N 0.703 0.386 0.411799315854 gnomAD-4.0.0 3.42116E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.79764E-05 0
P/A 32190 Fn3-122 86 rs1314931381 0.1321 -1.696 0.028 N 0.417 0.253 0.322230723748 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 4.64E-05 0 0
P/A 32190 Fn3-122 86 rs1314931381 0.1321 -1.696 0.028 N 0.417 0.253 0.322230723748 gnomAD-4.0.0 1.59126E-06 None None None None N None 0 0 None 0 0 None 1.88239E-05 0 0 0 0
P/A 32288 Fn3-123 87 None 0.1049 None 0.002 N 0.482 0.234 0.0846915920261 gnomAD-4.0.0 4.11837E-06 None None None None I None 0 0 None 0 7.57805E-05 None 0 0 2.70704E-06 0 0
Y/H 32485 Fn3-124 87 None 0.466 None 0.998 N 0.673 0.324 0.324161360171 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/A 32585 Fn3-125 87 None 0.0975 None 1.0 N 0.743 0.345 0.304108284078 gnomAD-4.0.0 7.12848E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.71857E-05
P/R 32585 Fn3-125 87 rs373959972 0.5725 -0.209 1.0 N 0.854 0.527 None gnomAD-2.1.1 5.63E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.38E-05 0
P/R 32585 Fn3-125 87 rs373959972 0.5725 -0.209 1.0 N 0.854 0.527 None gnomAD-4.0.0 7.135E-06 None None None None I None 0 0 None 0 0 None 0 0 9.2889E-06 0 0
P/A 32686 Fn3-126 87 None 0.096 None 0.767 N 0.465 0.233 0.225902525712 gnomAD-4.0.0 6.86024E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.66118E-05
P/S 32686 Fn3-126 87 None 0.2799 None 0.998 N 0.705 0.342 0.27132560031 gnomAD-4.0.0 6.86024E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01817E-07 0 0
P/T 32686 Fn3-126 87 None 0.2788 None 0.999 N 0.711 0.339 0.461671691612 gnomAD-4.0.0 1.37205E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80363E-06 0 0
P/H 32881 Fn3-127 87 None 0.2748 None 0.484 N 0.619 0.463 0.317958651998 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/S 32881 Fn3-127 87 rs367979582 0.0983 -1.352 None N 0.384 0.147 0.124217242631 gnomAD-2.1.1 9.99E-05 None None None None N None 0 0 None 0 1.12774E-03 None 1.96117E-04 None 0 0 0
P/S 32881 Fn3-127 87 rs367979582 0.0983 -1.352 None N 0.384 0.147 0.124217242631 gnomAD-3.1.2 7.89E-05 None None None None N None 0 0 0 0 1.54024E-03 None 0 0 0 8.28157E-04 0
P/S 32881 Fn3-127 87 rs367979582 0.0983 -1.352 None N 0.384 0.147 0.124217242631 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 2E-03 0 None None None 0 None
P/S 32881 Fn3-127 87 rs367979582 0.0983 -1.352 None N 0.384 0.147 0.124217242631 gnomAD-4.0.0 4.52369E-05 None None None None N None 0 0 None 0 6.01712E-04 None 0 0 3.39061E-06 3.51339E-04 1.60067E-04
P/L 33084 Fn3-129 87 None 0.7594 None 1.0 N 0.761 0.458 0.776403684517 gnomAD-4.0.0 1.59212E-06 None None None None N None 0 0 None 0 0 None 0 2.41663E-04 0 0 0
P/H 33377 Fn3-130 88 None 0.3565 None 0.975 D 0.605 0.383 0.558147714631 gnomAD-4.0.0 1.59254E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85995E-06 0 0
W/C 33478 Fn3-131 87 rs1449345093 0.8546 -0.984 1.0 N 0.706 0.378 0.218845423259 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
W/G 33478 Fn3-131 87 rs372304158 0.5276 -2.745 0.999 N 0.65 0.53 None gnomAD-2.1.1 1.92912E-04 None None None None N None 0 5.67E-05 None 0 0 None 9.81E-05 None 4E-05 3.59414E-04 2.81373E-04
W/G 33478 Fn3-131 87 rs372304158 0.5276 -2.745 0.999 N 0.65 0.53 None gnomAD-3.1.2 1.70819E-04 None None None None N None 2.41E-05 0 0 0 0 None 0 0 3.52775E-04 0 4.78011E-04
W/G 33478 Fn3-131 87 rs372304158 0.5276 -2.745 0.999 N 0.65 0.53 None gnomAD-4.0.0 3.0367E-04 None None None None N None 4.00406E-05 5.00217E-05 None 0 0 None 6.25528E-05 0 3.8906E-04 5.49028E-05 2.56189E-04
P/S 33773 Fn3-132 85 rs768248494 0.6618 -1.002 0.979 N 0.714 0.38 0.313818047136 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
P/S 33773 Fn3-132 85 rs768248494 0.6618 -1.002 0.979 N 0.714 0.38 0.313818047136 gnomAD-4.0.0 1.59118E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85788E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.