Structural position:

  • Domain Type: Fn3
  • Aligned Position: 124
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand G

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
D/G 15747 Fn3-1 91 None 0.1096 None 0.376 N 0.481 0.165 0.230578612272 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
L/F 15949 Fn3-3 91 None 0.2044 None 0.933 N 0.608 0.107 0.365120060079 gnomAD-4.0.0 6.86919E-07 None None None None N None 0 0 None 0 2.5505E-05 None 0 0 0 0 0
L/I 15949 Fn3-3 91 None 0.0827 None 0.005 N 0.155 0.034 0.218845423259 gnomAD-4.0.0 6.86919E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01728E-07 0 0
L/V 15949 Fn3-3 91 rs759304727 0.0843 -0.662 0.022 N 0.16 0.056 0.234412748748 gnomAD-2.1.1 8.34E-06 None None None None N None 0 5.97E-05 None 0 0 None 0 None 0 0 0
L/V 15949 Fn3-3 91 rs759304727 0.0843 -0.662 0.022 N 0.16 0.056 0.234412748748 gnomAD-3.1.2 6.59E-06 None None None None N None 0 6.57E-05 0 0 0 None 0 0 0 0 0
L/V 15949 Fn3-3 91 rs759304727 0.0843 -0.662 0.022 N 0.16 0.056 0.234412748748 gnomAD-4.0.0 1.24408E-06 None None None None N None 0 3.37781E-05 None 0 0 None 0 0 0 0 0
D/A 16144 Fn3-4 90 rs879133118 0.1214 0.311 0.995 N 0.626 0.355 0.324161360171 gnomAD-2.1.1 2.01E-05 None None None None N None 2.59E-04 0 None 0 0 None 0 None 0 0 1.66058E-04
D/A 16144 Fn3-4 90 rs879133118 0.1214 0.311 0.995 N 0.626 0.355 0.324161360171 gnomAD-3.1.2 5.27E-05 None None None None N None 1.93293E-04 0 0 0 0 None 0 0 0 0 0
D/A 16144 Fn3-4 90 rs879133118 0.1214 0.311 0.995 N 0.626 0.355 0.324161360171 gnomAD-4.0.0 7.44259E-06 None None None None N None 1.4711E-04 0 None 0 0 None 0 0 0 0 1.60298E-05
D/E 16144 Fn3-4 90 rs776643336 0.1161 None 0.429 N 0.315 0.052 0.219573609325 gnomAD-4.0.0 6.84702E-07 None None None None N None 0 0 None 0 0 None 0 0 9.0005E-07 0 0
T/I 16244 Fn3-5 90 None 0.8795 None 0.999 D 0.869 0.352 0.473458370588 gnomAD-4.0.0 1.69463E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.53271E-05 0
T/A 16540 Fn3-7 91 rs1179983336 0.428 -0.772 0.997 N 0.628 0.3 0.282575091529 gnomAD-2.1.1 8.11E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
T/A 16540 Fn3-7 91 rs1179983336 0.428 -0.772 0.997 N 0.628 0.3 0.282575091529 gnomAD-4.0.0 7.53934E-06 None None None None N None 0 0 None 0 0 None 0 0 9.90208E-06 0 0
T/I 16540 Fn3-7 91 rs1486530087 0.8486 0.227 0.999 N 0.848 0.351 0.37281450598 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
T/I 16540 Fn3-7 91 rs1486530087 0.8486 0.227 0.999 N 0.848 0.351 0.37281450598 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
T/I 16540 Fn3-7 91 rs1486530087 0.8486 0.227 0.999 N 0.848 0.351 0.37281450598 gnomAD-4.0.0 2.57113E-06 None None None None N None 0 1.70375E-05 None 0 0 None 0 0 2.3987E-06 0 0
S/N 16640 Fn3-8 90 rs55663050 0.8875 None 0.997 D 0.633 0.37 0.508223314113 gnomAD-4.0.0 6.84922E-07 None None None None N None 2.99419E-05 0 None 0 0 None 0 0 0 0 0
S/T 16640 Fn3-8 90 rs55663050 0.1531 -0.57 0.997 N 0.599 0.233 None gnomAD-2.1.1 3.43582E-03 None None None None N None 2.07228E-04 7.68618E-04 None 1.07046E-03 1.04362E-04 None 2.17563E-02 None 4.01E-05 1.77501E-03 2.97114E-03
S/T 16640 Fn3-8 90 rs55663050 0.1531 -0.57 0.997 N 0.599 0.233 None gnomAD-3.1.2 1.79752E-03 None None None None N None 2.41534E-04 1.83872E-03 0 8.65052E-04 0 None 0 0 1.66387E-03 2.38986E-02 1.91388E-03
S/T 16640 Fn3-8 90 rs55663050 0.1531 -0.57 0.997 N 0.599 0.233 None 1000 genomes 5.99042E-03 None None None None N None 0 1.4E-03 None None 0 2E-03 None None None 2.76E-02 None
S/T 16640 Fn3-8 90 rs55663050 0.1531 -0.57 0.997 N 0.599 0.233 None gnomAD-4.0.0 2.19912E-03 None None None None N None 3.20333E-04 9.85732E-04 None 8.46024E-04 1.57226E-04 None 6.25469E-05 4.13633E-03 1.08908E-03 2.1267E-02 2.94957E-03
E/G 16740 Fn3-9 90 rs1314963445 0.1807 -0.056 None N 0.283 0.106 0.235038932564 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/G 16740 Fn3-9 90 rs1314963445 0.1807 -0.056 None N 0.283 0.106 0.235038932564 gnomAD-4.0.0 6.57903E-06 None None None None I None 2.41441E-05 0 None 0 0 None 0 0 0 0 0
E/K 16740 Fn3-9 90 rs771586396 0.3313 0.737 0.058 N 0.456 0.115 0.258779203287 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/K 16740 Fn3-9 90 rs771586396 0.3313 0.737 0.058 N 0.456 0.115 0.258779203287 gnomAD-4.0.0 2.05414E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79978E-06 1.16012E-05 0
T/I 16841 Fn3-10 91 None 0.9203 None 0.287 N 0.636 0.277 0.266385636622 gnomAD-4.0.0 1.59379E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86225E-06 0 0
T/R 16841 Fn3-10 91 None 0.9658 None 0.943 D 0.663 0.428 0.404592120364 gnomAD-4.0.0 1.59379E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86225E-06 0 0
K/N 17136 Fn3-12 90 None 0.4165 None 0.651 N 0.413 0.12 0.17258766438 gnomAD-4.0.0 1.59321E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86159E-06 0 0
T/A 17237 Fn3-13 91 rs1353786897 0.4374 -1.042 0.997 N 0.595 0.23 0.198526703765 gnomAD-2.1.1 4.11E-06 None None None None N None 0 2.93E-05 None 0 0 None 0 None 0 0 0
T/I 17237 Fn3-13 91 rs556967635 0.8131 -0.025 0.999 N 0.881 0.344 0.401327265625 gnomAD-2.1.1 9.45E-05 None None None None N None 6.48E-05 0 None 0 0 None 7.49625E-04 None 0 0 0
T/I 17237 Fn3-13 91 rs556967635 0.8131 -0.025 0.999 N 0.881 0.344 0.401327265625 gnomAD-3.1.2 1.97E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 4.13907E-04 0
T/I 17237 Fn3-13 91 rs556967635 0.8131 -0.025 0.999 N 0.881 0.344 0.401327265625 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
T/I 17237 Fn3-13 91 rs556967635 0.8131 -0.025 0.999 N 0.881 0.344 0.401327265625 gnomAD-4.0.0 3.9276E-05 None None None None N None 1.33729E-05 0 None 0 0 None 0 0 0 6.683E-04 3.22373E-05
T/P 17237 Fn3-13 91 None 0.7603 None 0.999 N 0.872 0.291 0.379881503574 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
S/A 17559 Fn3-15 90 rs2055393436 0.4944 None 0.994 N 0.633 0.188 0.340032825777 gnomAD-4.0.0 1.20032E-05 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-05 0 0
L/I 17952 Fn3-18 91 None 0.1681 None 0.666 N 0.536 0.055 0.236890367714 gnomAD-4.0.0 1.60772E-06 None None None None N None 0 0 None 0 0 None 0 0 2.88944E-06 0 0
L/R 17952 Fn3-18 91 rs1419642739 0.8304 -1.19 0.966 N 0.709 0.408 0.639332231701 gnomAD-2.1.1 4.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.02E-06 0
L/R 17952 Fn3-18 91 rs1419642739 0.8304 -1.19 0.966 N 0.709 0.408 0.639332231701 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
L/R 17952 Fn3-18 91 rs1419642739 0.8304 -1.19 0.966 N 0.709 0.408 0.639332231701 gnomAD-4.0.0 1.31605E-05 None None None None N None 0 0 None 0 0 None 0 0 2.94421E-05 0 0
S/P 18261 Fn3-20 96 None 0.9918 None 0.999 N 0.764 0.295 0.395289904662 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
T/A 18364 Fn3-21 93 rs1467489292 0.1497 None 0.997 N 0.677 0.211 0.335910606209 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/A 18364 Fn3-21 93 rs1467489292 0.1497 None 0.997 N 0.677 0.211 0.335910606209 gnomAD-4.0.0 6.57748E-06 None None None None N None 2.41301E-05 0 None 0 0 None 0 0 0 0 0
V/I 18674 Fn3-23 96 None 0.0955 None 0.132 N 0.391 0.154 0.269558022972 gnomAD-4.0.0 2.05385E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79984E-06 0 1.65793E-05
V/L 18674 Fn3-23 96 rs753094651 0.2857 -0.082 0.702 N 0.593 0.18 0.254244900254 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 9.98E-05 0 None 0 None 0 0 0
T/I 19078 Fn3-26 91 rs1452086800 0.1933 0.455 0.294 N 0.68 0.196 0.324986149311 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/I 19078 Fn3-26 91 rs1452086800 0.1933 0.455 0.294 N 0.68 0.196 0.324986149311 gnomAD-4.0.0 1.59238E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4334E-05 0
S/L 19273 Fn3-27 91 None 0.0811 None 0.001 N 0.203 0.124 0.47558534428 gnomAD-4.0.0 1.72985E-06 None None None None I None 0 0 None 0 0 None 0 0 3.09868E-06 0 0
S/T 19273 Fn3-27 91 rs778433386 0.064 None None N 0.065 0.054 0.0482279557977 gnomAD-2.1.1 5.66E-06 None None None None I None 9.69E-05 0 None 0 0 None 0 None 0 0 0
S/T 19273 Fn3-27 91 rs778433386 0.064 None None N 0.065 0.054 0.0482279557977 gnomAD-3.1.2 1.98E-05 None None None None I None 7.27E-05 0 0 0 0 None 0 0 0 0 0
S/T 19273 Fn3-27 91 rs778433386 0.064 None None N 0.065 0.054 0.0482279557977 gnomAD-4.0.0 6.84774E-06 None None None None I None 6.92497E-05 0 None 0 0 None 0 0 2.5583E-06 0 0
T/A 19374 Fn3-28 91 None 0.6221 None 0.997 N 0.569 0.236 0.254761474806 gnomAD-4.0.0 1.63015E-06 None None None None N None 0 0 None 0 2.79736E-05 None 0 0 0 0 0
T/S 19374 Fn3-28 91 rs794729463 0.4066 -1.335 0.997 N 0.561 0.256 0.204665344411 gnomAD-2.1.1 6.37E-05 None None None None N None 2.29463E-04 0 None 0 0 None 0 None 0 0 0
T/S 19374 Fn3-28 91 rs794729463 0.4066 -1.335 0.997 N 0.561 0.256 0.204665344411 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
T/S 19374 Fn3-28 91 rs794729463 0.4066 -1.335 0.997 N 0.561 0.256 0.204665344411 gnomAD-4.0.0 6.53395E-06 None None None None N None 8.55315E-05 0 None 0 0 None 0 0 0 0 0
S/P 19669 Fn3-30 91 None 0.9945 None 0.999 D 0.849 0.421 0.532600205719 gnomAD-4.0.0 1.5921E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85936E-06 0 0
P/L 19772 Fn3-31 93 rs72646840 0.1323 -0.027 0.913 N 0.483 0.195 None gnomAD-2.1.1 1.06161E-03 None None None None I None 1.04967E-02 5.66572E-04 None 0 0 None 3.27E-05 None 0 1.487E-04 4.21467E-04
P/L 19772 Fn3-31 93 rs72646840 0.1323 -0.027 0.913 N 0.483 0.195 None gnomAD-3.1.2 3.06381E-03 None None None None I None 1.03538E-02 8.51566E-04 0 0 0 None 0 0 2.79387E-04 2.07297E-04 1.91205E-03
P/L 19772 Fn3-31 93 rs72646840 0.1323 -0.027 0.913 N 0.483 0.195 None 1000 genomes 2.39617E-03 None None None None I None 7.6E-03 2.9E-03 None None 0 0 None None None 0 None
P/L 19772 Fn3-31 93 rs72646840 0.1323 -0.027 0.913 N 0.483 0.195 None gnomAD-4.0.0 6.8734E-04 None None None None I None 1.07194E-02 6.66867E-04 None 0 0 None 0 1.6518E-04 1.67851E-04 6.58906E-05 9.60461E-04
P/Q 19772 Fn3-31 93 None 0.1555 None 0.943 N 0.479 0.166 0.340753184043 gnomAD-4.0.0 2.05304E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 4.97051E-05
P/R 19772 Fn3-31 93 rs72646840 0.1866 None 0.006 N 0.331 0.184 0.255270683199 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
P/R 19772 Fn3-31 93 rs72646840 0.1866 None 0.006 N 0.331 0.184 0.255270683199 gnomAD-4.0.0 6.57462E-06 None None None None I None 2.41336E-05 0 None 0 0 None 0 0 0 0 0
P/T 19772 Fn3-31 93 rs773420166 0.1054 -0.179 0.651 N 0.45 0.186 0.308904156042 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
P/T 19772 Fn3-31 93 rs773420166 0.1054 -0.179 0.651 N 0.45 0.186 0.308904156042 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/T 19772 Fn3-31 93 rs773420166 0.1054 -0.179 0.651 N 0.45 0.186 0.308904156042 gnomAD-4.0.0 1.8595E-06 None None None None I None 0 0 None 0 0 None 0 0 2.54319E-06 0 0
P/L 19966 Fn3-32 90 None 0.09 None None N 0.286 0.134 0.30921473904 gnomAD-4.0.0 1.59321E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86058E-06 0 0
P/S 19966 Fn3-32 90 None 0.0876 None 0.001 N 0.18 0.106 0.18274738541 gnomAD-4.0.0 1.59315E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02718E-05
P/T 19966 Fn3-32 90 rs2154185337 0.0744 None None N 0.126 0.135 0.215109475489 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93723E-04 None 0 0 0 0 0
P/T 19966 Fn3-32 90 rs2154185337 0.0744 None None N 0.126 0.135 0.215109475489 gnomAD-4.0.0 6.57022E-06 None None None None N None 0 0 None 0 1.94175E-04 None 0 0 0 0 0
T/A 20064 Fn3-33 88 None 0.3169 None 0.997 N 0.709 0.267 0.261217442401 gnomAD-4.0.0 1.59225E-06 None None None None N None 5.66572E-05 0 None 0 0 None 0 0 0 0 0
T/I 20261 Fn3-34 91 rs555901678 0.0641 0.392 None N 0.427 0.126 0.0401082797425 gnomAD-2.1.1 7.16E-06 None None None None N None 4.13E-05 0 None 0 0 None 0 None 0 7.85E-06 0
T/I 20261 Fn3-34 91 rs555901678 0.0641 0.392 None N 0.427 0.126 0.0401082797425 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
T/I 20261 Fn3-34 91 rs555901678 0.0641 0.392 None N 0.427 0.126 0.0401082797425 gnomAD-4.0.0 1.7356E-05 None None None None N None 1.86936E-04 0 None 0 0 None 0 0 1.10214E-05 0 1.60138E-05
T/K 20261 Fn3-34 91 rs555901678 0.0878 -0.335 None N 0.422 0.142 0.0297737177859 gnomAD-2.1.1 5.65E-05 None None None None N None 0 0 None 0 0 None 4.24975E-04 None 0 0 1.665E-04
T/K 20261 Fn3-34 91 rs555901678 0.0878 -0.335 None N 0.422 0.142 0.0297737177859 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 0 6.21375E-04 0
T/K 20261 Fn3-34 91 rs555901678 0.0878 -0.335 None N 0.422 0.142 0.0297737177859 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 0 0 None None None 2E-03 None
T/K 20261 Fn3-34 91 rs555901678 0.0878 -0.335 None N 0.422 0.142 0.0297737177859 gnomAD-4.0.0 1.92142E-05 None None None None N None 0 0 None 0 0 None 0 0 0 3.40457E-04 0
T/P 20261 Fn3-34 91 rs1343412391 0.0584 None 0.031 N 0.673 0.027 0.0806252709748 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/P 20261 Fn3-34 91 rs1343412391 0.0584 None 0.031 N 0.673 0.027 0.0806252709748 gnomAD-4.0.0 6.5773E-06 None None None None N None 2.41313E-05 0 None 0 0 None 0 0 0 0 0
T/S 20261 Fn3-34 91 rs1343412391 0.0845 -0.892 0.001 N 0.417 0.023 0.0297737177859 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
A/T 20462 Fn3-36 92 rs1461584789 0.098 -0.415 0.361 N 0.272 0.101 0.18274738541 gnomAD-2.1.1 4.68E-06 None None None None I None 6.64E-05 0 None 0 0 None 0 None 0 0 0
A/T 20462 Fn3-36 92 rs1461584789 0.098 -0.415 0.361 N 0.272 0.101 0.18274738541 gnomAD-4.0.0 6.81006E-06 None None None None I None 1.21788E-04 0 None 0 0 None 0 0 0 0 6.4E-05
E/K 20758 Fn3-38 91 rs794729470 0.141 None 0.039 N 0.253 0.124 None gnomAD-4.0.0 7.5279E-06 None None None None I None 0 0 None 0 0 None 0 0 9.89502E-06 0 0
E/V 20758 Fn3-38 91 None 0.2582 None 0.047 N 0.425 0.182 0.281381271821 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/N 20953 Fn3-39 90 rs765002114 0.3044 0.012 0.961 N 0.608 0.084 0.178374595973 gnomAD-2.1.1 2.5E-05 None None None None N None 8.32E-05 0 None 0 0 None 0 None 0 3.91E-05 0
K/N 20953 Fn3-39 90 rs765002114 0.3044 0.012 0.961 N 0.608 0.084 0.178374595973 gnomAD-3.1.2 3.95E-05 None None None None N None 0 0 0 0 0 None 0 0 8.83E-05 0 0
K/N 20953 Fn3-39 90 rs765002114 0.3044 0.012 0.961 N 0.608 0.084 0.178374595973 gnomAD-4.0.0 1.79765E-05 None None None None N None 2.67037E-05 0 None 0 0 None 0 1.64528E-04 2.11935E-05 0 1.60159E-05
E/K 21456 Fn3-43 91 rs1432709459 0.3262 None 0.457 N 0.521 0.183 0.250039746154 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
P/L 21649 Fn3-44 91 rs1220907025 0.1339 -0.068 0.337 N 0.511 0.227 0.475663983558 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
P/L 21649 Fn3-44 91 rs1220907025 0.1339 -0.068 0.337 N 0.511 0.227 0.475663983558 gnomAD-4.0.0 1.59196E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85979E-06 0 0
T/I 21749 Fn3-45 91 rs557155501 0.8908 None 0.999 N 0.865 0.34 0.501685917333 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 21749 Fn3-45 91 rs557155501 0.8908 None 0.999 N 0.865 0.34 0.501685917333 gnomAD-4.0.0 3.14023E-06 None None None None N None 0 0 None 0 0 None 0 0 4.28636E-06 0 0
S/F 21849 Fn3-46 93 rs1060500465 0.9735 None 0.999 N 0.886 0.396 0.58951732002 gnomAD-4.0.0 3.20569E-06 None None None None N None 0 0 None 0 0 None 0 0 5.76073E-06 0 0
S/P 22145 Fn3-48 91 None 0.991 None 0.999 N 0.839 0.461 0.36453787251 gnomAD-4.0.0 1.5926E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86043E-06 0 0
S/Y 22145 Fn3-48 91 None 0.9915 None 0.999 N 0.861 0.443 0.600100745787 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/L 22247 Fn3-49 92 rs749070757 0.2603 -0.077 0.974 N 0.655 0.367 0.408307896497 gnomAD-2.1.1 4.08E-06 None None None None I None 6.47E-05 0 None 0 0 None 0 None 0 0 0
P/L 22247 Fn3-49 92 rs749070757 0.2603 -0.077 0.974 N 0.655 0.367 0.408307896497 gnomAD-4.0.0 3.43944E-06 None None None None I None 3.00228E-05 0 None 0 0 None 0 0 3.61575E-06 0 0
R/C 22443 Fn3-50 90 rs1304938868 0.1767 -0.036 0.997 N 0.343 0.245 0.495372917472 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.92E-06 0
R/C 22443 Fn3-50 90 rs1304938868 0.1767 -0.036 0.997 N 0.343 0.245 0.495372917472 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 22443 Fn3-50 90 rs1304938868 0.1767 -0.036 0.997 N 0.343 0.245 0.495372917472 gnomAD-4.0.0 6.41095E-06 None None None None N None 0 0 None 0 0 None 0 0 9.57909E-06 1.34088E-05 0
R/H 22443 Fn3-50 90 rs1389670032 0.1083 -0.511 0.971 N 0.313 0.181 0.165133752707 gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 5.16E-05 None 0 None 0 1.57E-05 0
R/H 22443 Fn3-50 90 rs1389670032 0.1083 -0.511 0.971 N 0.313 0.181 0.165133752707 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94175E-04 None 0 0 0 0 0
R/H 22443 Fn3-50 90 rs1389670032 0.1083 -0.511 0.971 N 0.313 0.181 0.165133752707 gnomAD-4.0.0 9.91934E-06 None None None None N None 0 0 None 0 6.70062E-05 None 0 0 1.0174E-05 1.09847E-05 0
E/A 22733 Fn3-52 91 rs754767867 0.1024 0.089 0.03 N 0.458 0.246 0.230578612272 gnomAD-2.1.1 1.79E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.14E-05 1.41163E-04
E/A 22733 Fn3-52 91 rs754767867 0.1024 0.089 0.03 N 0.458 0.246 0.230578612272 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/A 22733 Fn3-52 91 rs754767867 0.1024 0.089 0.03 N 0.458 0.246 0.230578612272 gnomAD-4.0.0 1.24118E-05 None None None None N None 0 0 None 0 0 None 0 0 1.69725E-05 0 0
E/G 22733 Fn3-52 91 rs754767867 0.1106 -0.144 0.058 N 0.547 0.228 0.269111216191 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.31E-05 None 0 0 0
E/G 22733 Fn3-52 91 rs754767867 0.1106 -0.144 0.058 N 0.547 0.228 0.269111216191 gnomAD-4.0.0 6.85239E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16439E-05 0
E/Q 22733 Fn3-52 91 None 0.109 None 0.058 N 0.582 0.132 0.187945064343 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
S/L 22833 Fn3-53 91 rs876658077 0.5468 None 0.666 N 0.55 0.432 0.43656330218 gnomAD-4.0.0 1.59274E-06 None None None None I None 5.66765E-05 0 None 0 0 None 0 0 0 0 0
T/S 22932 Fn3-54 92 None 0.1881 None 0.914 N 0.411 0.179 0.201204373187 gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.93751E-06 0 0
P/L 23331 Fn3-57 92 None 0.163 None 0.058 N 0.505 0.146 0.355658859761 gnomAD-4.0.0 1.5921E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85961E-06 0 0
T/A 23524 Fn3-58 90 rs369526268 0.0559 0.078 None N 0.038 0.093 None gnomAD-2.1.1 2.82E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.23E-05 0
T/A 23524 Fn3-58 90 rs369526268 0.0559 0.078 None N 0.038 0.093 None gnomAD-3.1.2 4.6E-05 None None None None N None 0 0 0 0 0 None 0 0 1.02938E-04 0 0
T/A 23524 Fn3-58 90 rs369526268 0.0559 0.078 None N 0.038 0.093 None gnomAD-4.0.0 5.57772E-05 None None None None N None 0 0 None 0 0 None 1.56187E-05 0 7.29019E-05 0 4.80338E-05
T/K 23524 Fn3-58 90 rs748544908 0.1172 0.083 None N 0.111 0.087 0.201204373187 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/K 23524 Fn3-58 90 rs748544908 0.1172 0.083 None N 0.111 0.087 0.201204373187 gnomAD-4.0.0 6.84257E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.1595E-05 0
T/R 23524 Fn3-58 90 None 0.1154 None 0.112 N 0.421 0.069 0.358134431457 gnomAD-4.0.0 6.84257E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.1595E-05 0
A/T 23816 Fn3-60 91 None 0.0674 None None N 0.139 0.066 0.411133732114 gnomAD-4.0.0 1.36883E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79926E-06 0 0
A/V 23816 Fn3-60 91 rs1270658068 0.1004 None 0.03 N 0.251 0.097 0.514530392947 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/V 23816 Fn3-60 91 rs1270658068 0.1004 None 0.03 N 0.251 0.097 0.514530392947 gnomAD-4.0.0 3.84561E-06 None None None None I None 0 0 None 0 0 None 0 0 4.78842E-06 1.34138E-05 0
S/L 23916 Fn3-61 91 rs1283305854 0.5084 0.36 0.999 N 0.745 0.444 0.559195274915 gnomAD-2.1.1 7.14E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.56E-05 0
S/L 23916 Fn3-61 91 rs1283305854 0.5084 0.36 0.999 N 0.745 0.444 0.559195274915 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/L 23916 Fn3-61 91 rs1283305854 0.5084 0.36 0.999 N 0.745 0.444 0.559195274915 gnomAD-4.0.0 5.12584E-06 None None None None N None 0 0 None 0 0 None 0 0 9.57529E-06 0 0
P/R 24414 Fn3-65 92 rs769320646 0.376 None 0.987 N 0.634 0.46 0.527557778142 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.62E-05 None 0 None 0 0 0
P/R 24414 Fn3-65 92 rs769320646 0.376 None 0.987 N 0.634 0.46 0.527557778142 gnomAD-4.0.0 2.05312E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69879E-06 0 0
A/T 24608 Fn3-66 90 rs750166986 0.0623 -0.265 None N 0.184 0.137 0.166414681773 gnomAD-2.1.1 1.43E-05 None None None None N None 4.13E-05 5.67E-05 None 0 0 None 0 None 0 0 1.41084E-04
A/T 24608 Fn3-66 90 rs750166986 0.0623 -0.265 None N 0.184 0.137 0.166414681773 gnomAD-3.1.2 3.95E-05 None None None None N None 2.41E-05 2.62192E-04 0 0 0 None 0 0 1.47E-05 0 0
A/T 24608 Fn3-66 90 rs750166986 0.0623 -0.265 None N 0.184 0.137 0.166414681773 gnomAD-4.0.0 1.55176E-05 None None None None N None 1.33583E-05 1.3352E-04 None 0 2.23704E-05 None 0 1.64908E-04 8.49072E-06 2.19771E-05 3.20842E-05
S/R 24704 Fn3-67 89 rs397517697 0.7375 None 0.965 N 0.813 0.279 0.242825505644 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/R 24704 Fn3-67 89 rs397517697 0.7375 None 0.965 N 0.813 0.279 0.242825505644 gnomAD-4.0.0 6.578E-06 None None None None I None 2.41476E-05 0 None 0 0 None 0 0 0 0 0
E/D 24898 Fn3-68 91 None 0.0908 None 0.003 N 0.211 0.063 0.166414681773 gnomAD-4.0.0 6.84332E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99583E-07 0 0
E/K 24898 Fn3-68 91 rs751312481 0.0888 None 0.007 N 0.428 0.152 0.236278675362 gnomAD-3.1.2 3.29E-05 None None None None N None 1.20732E-04 0 0 0 0 None 0 0 0 0 0
E/K 24898 Fn3-68 91 rs751312481 0.0888 None 0.007 N 0.428 0.152 0.236278675362 gnomAD-4.0.0 7.69022E-06 None None None None N None 1.01561E-04 0 None 0 0 None 0 0 0 0 0
E/Q 24898 Fn3-68 91 rs751312481 0.101 -0.634 0.883 N 0.699 0.178 0.19670166235 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
E/Q 24898 Fn3-68 91 rs751312481 0.101 -0.634 0.883 N 0.699 0.178 0.19670166235 gnomAD-4.0.0 3.18381E-06 None None None None N None 0 0 None 0 0 None 0 0 5.7188E-06 0 0
T/I 25097 Fn3-70 92 rs777052871 0.8546 -0.14 0.015 N 0.549 0.284 0.167679373172 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/I 25097 Fn3-70 92 rs777052871 0.8546 -0.14 0.015 N 0.549 0.284 0.167679373172 gnomAD-4.0.0 1.59175E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85925E-06 0 0
T/K 25097 Fn3-70 92 None 0.9455 None 0.883 N 0.792 0.394 0.214338557667 gnomAD-4.0.0 1.59175E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85925E-06 0 0
P/R 25496 Fn3-73 92 rs886039105 0.2033 0.15 1.0 N 0.673 0.419 None gnomAD-2.1.1 3.19E-05 None None None None I None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
P/R 25496 Fn3-73 92 rs886039105 0.2033 0.15 1.0 N 0.673 0.419 None gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
P/R 25496 Fn3-73 92 rs886039105 0.2033 0.15 1.0 N 0.673 0.419 None gnomAD-4.0.0 1.31555E-05 None None None None I None 4.82835E-05 0 None 0 0 None 0 0 0 0 0
A/G 25690 Fn3-74 90 rs1344792922 0.0983 -0.021 None N 0.217 0.077 0.144782658237 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
A/G 25690 Fn3-74 90 rs1344792922 0.0983 -0.021 None N 0.217 0.077 0.144782658237 gnomAD-4.0.0 1.36883E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.32024E-05 0
A/T 25690 Fn3-74 90 rs758341420 0.0637 -0.113 None N 0.048 0.043 0.0666544352282 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
A/T 25690 Fn3-74 90 rs758341420 0.0637 -0.113 None N 0.048 0.043 0.0666544352282 gnomAD-4.0.0 9.58187E-06 None None None None I None 0 0 None 0 0 None 0 0 1.25951E-05 0 0
A/V 25690 Fn3-74 90 None 0.0696 None None N 0.103 0.058 0.207176502487 gnomAD-4.0.0 1.36883E-06 None None None None I None 2.99043E-05 0 None 0 0 None 0 0 8.99643E-07 0 0
A/E 25786 Fn3-75 89 None 0.6399 None 0.987 N 0.654 0.243 0.457286136841 gnomAD-4.0.0 2.73837E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59923E-06 0 0
D/E 25980 Fn3-76 91 rs977275961 0.0665 0.093 None N 0.081 0.086 0.0401082797425 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
D/E 25980 Fn3-76 91 rs977275961 0.0665 0.093 None N 0.081 0.086 0.0401082797425 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
D/E 25980 Fn3-76 91 rs977275961 0.0665 0.093 None N 0.081 0.086 0.0401082797425 gnomAD-4.0.0 1.31574E-05 None None None None N None 4.82882E-05 0 None 0 0 None 0 0 0 0 0
T/N 26179 Fn3-78 92 None 0.8114 None 0.986 N 0.717 0.341 0.266843984389 gnomAD-4.0.0 1.5965E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86829E-06 0 0
T/I 26476 Fn3-80 91 rs1457082371 0.8818 None 0.93 N 0.621 0.326 0.351830644314 gnomAD-4.0.0 1.59211E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85901E-06 0 0
T/P 26476 Fn3-80 91 None 0.7722 None 0.006 N 0.422 0.219 0.238096912614 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/R 26578 Fn3-81 92 rs1286290994 0.2327 -0.746 0.976 N 0.643 0.321 0.266843984389 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
P/R 26578 Fn3-81 92 rs1286290994 0.2327 -0.746 0.976 N 0.643 0.321 0.266843984389 gnomAD-4.0.0 3.18376E-06 None None None None N None 0 2.28645E-05 None 0 2.77331E-05 None 0 0 0 0 0
V/A 26772 Fn3-82 90 None 0.0653 None None N 0.031 0.082 0.268660756437 gnomAD-4.0.0 3.18318E-06 None None None None I None 0 0 None 0 0 None 0 0 5.7183E-06 0 0
V/I 26772 Fn3-82 90 rs750148761 0.0656 -0.051 None N 0.093 0.075 0.235664433957 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
V/I 26772 Fn3-82 90 rs750148761 0.0656 -0.051 None N 0.093 0.075 0.235664433957 gnomAD-4.0.0 6.15847E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.04341E-04 0
G/A 26868 Fn3-83 89 None 0.1474 None 0.025 N 0.184 0.215 0.149567049428 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/D 26868 Fn3-83 89 None 0.6383 None 0.993 N 0.625 0.276 0.304108284078 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
G/S 26868 Fn3-83 89 None 0.1565 None 0.908 N 0.375 0.229 0.203808441222 gnomAD-4.0.0 3.42159E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99593E-07 4.6379E-05 0
K/M 27062 Fn3-84 91 None 0.1875 None 0.468 N 0.393 0.164 0.246773566709 gnomAD-4.0.0 6.8486E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99954E-07 0 0
K/R 27062 Fn3-84 91 rs1705141926 0.0884 None 0.094 N 0.397 0.07 0.144782658237 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
K/R 27062 Fn3-84 91 rs1705141926 0.0884 None 0.094 N 0.397 0.07 0.144782658237 gnomAD-4.0.0 6.57212E-06 None None None None N None 0 6.54793E-05 None 0 0 None 0 0 0 0 0
K/T 27062 Fn3-84 91 None 0.1136 None 0.001 N 0.24 0.147 0.181679512989 gnomAD-4.0.0 2.05458E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79991E-06 0 1.65887E-05
S/L 27162 Fn3-85 91 rs763903239 0.7998 0.232 0.666 N 0.607 0.335 0.447213685739 gnomAD-2.1.1 1.43E-05 None None None None I None 1.6533E-04 0 None 0 0 None 0 None 0 0 0
S/L 27162 Fn3-85 91 rs763903239 0.7998 0.232 0.666 N 0.607 0.335 0.447213685739 gnomAD-3.1.2 2.63E-05 None None None None I None 9.65E-05 0 0 0 0 None 0 0 0 0 0
S/L 27162 Fn3-85 91 rs763903239 0.7998 0.232 0.666 N 0.607 0.335 0.447213685739 gnomAD-4.0.0 7.43772E-06 None None None None I None 1.60226E-04 0 None 0 0 None 0 0 0 0 0
S/P 27162 Fn3-85 91 rs1387276571 0.9846 0.196 0.989 D 0.637 0.425 0.250039746154 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.61E-05 None 0 None 0 0 0
S/G 27261 Fn3-86 92 None 0.3292 None 0.011 N 0.309 0.157 0.124217242631 gnomAD-4.0.0 1.59146E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8584E-06 0 0
S/T 27261 Fn3-86 92 rs1704859697 0.038 None None N 0.076 0.136 0.0986583533028 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/T 27261 Fn3-86 92 rs1704859697 0.038 None None N 0.076 0.136 0.0986583533028 gnomAD-4.0.0 2.56249E-06 None None None None I None 3.38306E-05 0 None 0 0 None 0 0 0 0 0
S/C 27559 Fn3-88 91 rs763989757 0.3596 -0.236 0.994 N 0.745 0.453 0.465381546717 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
S/C 27559 Fn3-88 91 rs763989757 0.3596 -0.236 0.994 N 0.745 0.453 0.465381546717 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
S/C 27559 Fn3-88 91 rs763989757 0.3596 -0.236 0.994 N 0.745 0.453 0.465381546717 gnomAD-4.0.0 5.12563E-06 None None None None N None 0 0 None 0 0 None 0 0 9.57336E-06 0 0
S/F 27559 Fn3-88 91 rs763989757 0.9666 -0.585 0.979 N 0.79 0.473 0.610564787575 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/F 27559 Fn3-88 91 rs763989757 0.9666 -0.585 0.979 N 0.79 0.473 0.610564787575 gnomAD-4.0.0 1.59153E-06 None None None None N None 0 2.28686E-05 None 0 0 None 0 0 0 0 0
S/P 27559 Fn3-88 91 None 0.9774 None 0.007 N 0.537 0.314 0.168933306366 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
P/L 27661 Fn3-89 92 rs770498921 0.1182 -0.008 0.007 N 0.626 0.325 0.520749599713 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.89E-06 0
P/L 27661 Fn3-89 92 rs770498921 0.1182 -0.008 0.007 N 0.626 0.325 0.520749599713 gnomAD-4.0.0 3.18288E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 3.02499E-05
P/S 27661 Fn3-89 92 rs201422612 0.1205 -0.313 0.162 N 0.439 0.175 None gnomAD-2.1.1 8.57E-05 None None None None N None 4.95991E-04 0 None 0 0 None 0 None 0 7.82E-05 2.80741E-04
P/S 27661 Fn3-89 92 rs201422612 0.1205 -0.313 0.162 N 0.439 0.175 None gnomAD-3.1.2 1.1832E-04 None None None None N None 2.89617E-04 0 0 0 0 None 0 0 8.82E-05 0 0
P/S 27661 Fn3-89 92 rs201422612 0.1205 -0.313 0.162 N 0.439 0.175 None gnomAD-4.0.0 7.43676E-05 None None None None N None 4.27282E-04 0 None 0 0 None 0 0 6.69655E-05 0 1.4412E-04
T/I 27855 Fn3-90 90 rs1268315067 0.0802 0.101 0.026 N 0.519 0.044 0.18274738541 gnomAD-2.1.1 3.18E-05 None None None None I None 1.14732E-04 0 None 0 0 None 0 None 0 0 0
T/I 27855 Fn3-90 90 rs1268315067 0.0802 0.101 0.026 N 0.519 0.044 0.18274738541 gnomAD-3.1.2 1.31E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
T/I 27855 Fn3-90 90 rs1268315067 0.0802 0.101 0.026 N 0.519 0.044 0.18274738541 gnomAD-4.0.0 1.8624E-06 None None None None I None 4.01263E-05 0 None 0 0 None 0 0 0 0 0
G/A 27951 Fn3-91 89 None 0.1588 None 0.006 N 0.083 0.161 0.149567049428 gnomAD-4.0.0 4.80129E-06 None None None None I None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
G/E 27951 Fn3-91 89 rs1316247758 0.6915 None 0.007 N 0.333 0.234 0.349204839081 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/E 27951 Fn3-91 89 rs1316247758 0.6915 None 0.007 N 0.333 0.234 0.349204839081 gnomAD-4.0.0 2.0299E-06 None None None None I None 1.74746E-05 0 None 0 0 None 0 0 0 0 3.40229E-05
G/R 27951 Fn3-91 89 rs786205374 0.7695 None 0.779 N 0.531 0.263 0.65198356138 gnomAD-4.0.0 2.05312E-06 None None None None I None 2.98882E-05 0 None 0 0 None 0 0 1.79912E-06 0 0
C/R 28244 Fn3-93 91 rs1249814057 0.9609 -0.882 0.779 N 0.695 0.252 0.479056812784 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
C/R 28244 Fn3-93 91 rs1249814057 0.9609 -0.882 0.779 N 0.695 0.252 0.479056812784 gnomAD-4.0.0 1.59125E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85817E-06 0 0
T/N 28343 Fn3-94 92 None 0.8479 None 0.964 D 0.697 0.476 0.514072065251 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
T/S 28343 Fn3-94 92 rs1703488961 0.2632 None 0.657 N 0.615 0.184 0.28058544554 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/C 28640 Fn3-96 91 rs952971526 0.1982 None 0.002 N 0.251 0.267 0.318252033908 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/C 28640 Fn3-96 91 rs952971526 0.1982 None 0.002 N 0.251 0.267 0.318252033908 gnomAD-4.0.0 4.05999E-06 None None None None I None 0 0 None 0 0 None 0 0 4.81974E-06 0 0
S/P 28640 Fn3-96 91 rs1703134059 0.9253 None 0.8 N 0.471 0.207 0.277730125212 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07297E-04 0
S/P 28640 Fn3-96 91 rs1703134059 0.9253 None 0.8 N 0.471 0.207 0.277730125212 gnomAD-4.0.0 2.03003E-06 None None None None I None 0 0 None 0 0 None 0 0 1.20493E-06 4.69836E-05 0
S/C 28740 Fn3-97 90 rs1348508376 0.1226 -0.017 0.778 N 0.546 0.391 0.405422107966 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
S/C 28740 Fn3-97 90 rs1348508376 0.1226 -0.017 0.778 N 0.546 0.391 0.405422107966 gnomAD-4.0.0 6.84277E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99484E-07 0 0
K/N 28934 Fn3-98 90 rs1280845808 0.3235 0.15 0.986 N 0.705 0.188 0.143124449307 gnomAD-2.1.1 4.24E-06 None None None None N None 0 0 None 0 0 None 3.67E-05 None 0 0 0
K/N 28934 Fn3-98 90 rs1280845808 0.3235 0.15 0.986 N 0.705 0.188 0.143124449307 gnomAD-4.0.0 1.38871E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.42266E-05 0
L/P 29030 Fn3-99 89 None 0.2465 None 0.028 N 0.609 0.204 0.540788926979 gnomAD-4.0.0 1.59212E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85879E-06 0 0
S/P 29327 Fn3-101 91 rs369714676 0.9898 0.23 0.994 N 0.673 0.476 None gnomAD-4.0.0 1.59115E-06 None None None None N None 0 0 None 0 2.77685E-05 None 0 0 0 0 0
V/A 29426 Fn3-102 92 None 0.0873 None None N 0.093 0.039 0.177238962908 gnomAD-4.0.0 5.474E-06 None None None None I None 0 0 None 0 0 None 0 0 7.19555E-06 0 0
V/G 29426 Fn3-102 92 None 0.2474 None 0.104 N 0.415 0.113 0.292062946507 gnomAD-4.0.0 6.8425E-07 None None None None I None 0 2.23624E-05 None 0 0 None 0 0 0 0 0
S/P 29723 Fn3-104 91 rs1479424442 0.9884 None 0.999 N 0.859 0.507 0.330331372229 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/P 29723 Fn3-104 91 rs1479424442 0.9884 None 0.999 N 0.859 0.507 0.330331372229 gnomAD-4.0.0 6.56944E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46968E-05 0 0
S/Y 29723 Fn3-104 91 None 0.9828 None 0.999 D 0.915 0.424 0.691544918794 gnomAD-4.0.0 1.61291E-06 None None None None N None 0 0 None 0 0 None 0 2.42718E-04 0 0 0
N/S 29825 Fn3-105 92 None 0.0648 None None N 0.064 0.122 0.0297737177859 gnomAD-4.0.0 1.59243E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02572E-05
T/I 30022 Fn3-106 90 rs771515515 0.091 0.112 0.257 N 0.565 0.149 0.340273420219 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 30022 Fn3-106 90 rs771515515 0.091 0.112 0.257 N 0.565 0.149 0.340273420219 gnomAD-4.0.0 2.02984E-06 None None None None N None 0 0 None 0 0 None 0 0 2.40984E-06 0 0
S/G 30314 Fn3-108 91 None 0.0713 None 0.001 D 0.176 0.133 0.208816687407 gnomAD-4.0.0 1.59504E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43349E-05 0
S/R 30314 Fn3-108 91 rs927742381 0.2589 None 0.008 N 0.425 0.17 0.27132560031 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/R 30314 Fn3-108 91 rs927742381 0.2589 None 0.008 N 0.425 0.17 0.27132560031 gnomAD-4.0.0 6.57419E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46998E-05 0 0
S/T 30314 Fn3-108 91 rs763875418 0.0751 0.001 None N 0.066 0.133 0.0401082797425 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/T 30314 Fn3-108 91 rs763875418 0.0751 0.001 None N 0.066 0.133 0.0401082797425 gnomAD-4.0.0 3.19001E-06 None None None None I None 0 4.57436E-05 None 0 0 None 0 0 0 0 0
S/N 30414 Fn3-109 91 rs1699490262 0.8963 None 0.355 D 0.331 0.299 0.166414681773 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.44E-05 0 0 0 0
S/N 30414 Fn3-109 91 rs1699490262 0.8963 None 0.355 D 0.331 0.299 0.166414681773 gnomAD-4.0.0 3.94937E-06 None None None None N None 0 0 None 0 0 None 3.16096E-05 0 2.46099E-06 0 0
S/T 30414 Fn3-109 91 None 0.1837 None 0.976 N 0.639 0.167 0.168933306366 gnomAD-4.0.0 1.64589E-06 None None None None N None 0 0 None 0 0 None 0 0 2.95543E-06 0 0
S/L 30810 Fn3-112 92 rs1021262891 0.8278 None 0.999 D 0.712 0.471 0.68573823706 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/L 30810 Fn3-112 92 rs1021262891 0.8278 None 0.999 D 0.712 0.471 0.68573823706 gnomAD-4.0.0 6.08976E-06 None None None None N None 0 0 None 0 0 None 0 0 7.22956E-06 0 0
T/I 30911 Fn3-113 91 rs1258281031 0.117 0.032 0.09 N 0.469 0.289 0.281381271821 gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 0 None 0 None 9.3E-05 0 0
T/I 30911 Fn3-113 91 rs1258281031 0.117 0.032 0.09 N 0.469 0.289 0.281381271821 gnomAD-4.0.0 4.77386E-06 None None None None I None 0 0 None 0 0 None 5.6527E-05 0 0 0 0
T/N 30911 Fn3-113 91 rs1258281031 0.0847 None 0.047 N 0.253 0.317 0.267755039894 gnomAD-4.0.0 1.90954E-05 None None None None I None 0 0 None 0 3.32889E-04 None 0 0 0 0 0
T/S 30911 Fn3-113 91 None 0.0799 None None N 0.111 0.069 0.107399877778 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
P/T 31105 Fn3-114 90 None 0.0661 None 0.01 N 0.201 0.098 0.191931220699 gnomAD-4.0.0 1.59118E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02389E-05
F/L 31201 Fn3-115 89 rs765759269 0.7911 None 0.06 N 0.302 0.205 0.368554958709 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
F/L 31201 Fn3-115 89 rs765759269 0.7911 None 0.06 N 0.302 0.205 0.368554958709 gnomAD-4.0.0 1.23938E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69521E-06 0 0
F/V 31201 Fn3-115 89 None 0.2689 None 0.91 N 0.607 0.302 0.485634191555 gnomAD-4.0.0 1.59118E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
A/T 31398 Fn3-116 91 rs779953838 0.0614 -0.29 None N 0.049 0.103 0.158396225186 gnomAD-2.1.1 1.66E-05 None None None None I None 0 1.18991E-04 None 0 0 None 0 None 0 0 0
A/T 31398 Fn3-116 91 rs779953838 0.0614 -0.29 None N 0.049 0.103 0.158396225186 gnomAD-4.0.0 4.84731E-06 None None None None I None 0 6.96023E-05 None 0 0 None 0 0 0 0 0
S/L 31498 Fn3-117 91 rs1281357207 0.8892 0.215 0.999 N 0.651 0.444 0.425970041486 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
S/L 31498 Fn3-117 91 rs1281357207 0.8892 0.215 0.999 N 0.651 0.444 0.425970041486 gnomAD-4.0.0 1.36918E-06 None None None None I None 0 0 None 0 0 None 0 0 1.7999E-06 0 0
T/A 31600 Fn3-118 95 rs1363231803 0.3597 -1.307 0.807 N 0.643 0.257 0.227260227426 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
T/A 31600 Fn3-118 95 rs1363231803 0.3597 -1.307 0.807 N 0.643 0.257 0.227260227426 gnomAD-4.0.0 2.05454E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70103E-06 0 0
I/L 32000 Fn3-121 92 None 0.0787 None 0.001 N 0.308 0.086 0.236278675362 gnomAD-4.0.0 6.8439E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65695E-05
I/T 32000 Fn3-121 92 rs772265662 0.0582 -2.224 None N 0.313 0.111 0.134241683229 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 1.78E-05 0
I/T 32000 Fn3-121 92 rs772265662 0.0582 -2.224 None N 0.313 0.111 0.134241683229 gnomAD-4.0.0 8.8972E-06 None None None None N None 0 2.23624E-05 None 0 0 None 0 0 9.89744E-06 0 1.65689E-05
I/V 32000 Fn3-121 92 rs769971164 0.0597 None None N 0.141 0.091 0.308904156042 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/V 32000 Fn3-121 92 rs769971164 0.0597 None None N 0.141 0.091 0.308904156042 gnomAD-4.0.0 1.17767E-05 None None None None N None 1.33469E-05 0 None 0 2.22816E-05 None 0 1.64582E-04 1.27177E-05 0 1.60149E-05
S/T 32194 Fn3-122 90 rs781737970 0.0692 -0.003 0.024 N 0.231 0.041 0.216624796971 gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
S/T 32194 Fn3-122 90 rs781737970 0.0692 -0.003 0.024 N 0.231 0.041 0.216624796971 gnomAD-4.0.0 3.18233E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71608E-06 0 0
V/I 32292 Fn3-123 91 rs746347387 0.085 -0.016 0.004 N 0.363 0.053 0.48286525802 gnomAD-2.1.1 1.22E-05 None None None None N None 0 5.82E-05 None 0 0 None 0 None 0 8.97E-06 0
V/I 32292 Fn3-123 91 rs746347387 0.085 -0.016 0.004 N 0.363 0.053 0.48286525802 gnomAD-3.1.2 6.64E-06 None None None None N None 0 6.63E-05 0 0 0 None 0 0 0 0 0
V/I 32292 Fn3-123 91 rs746347387 0.085 -0.016 0.004 N 0.363 0.053 0.48286525802 gnomAD-4.0.0 2.74561E-05 None None None None N None 0 5.0366E-05 None 0 0 None 0 0 3.32562E-05 0 3.22508E-05
E/G 32489 Fn3-124 91 rs987967114 0.154 -1.253 0.988 N 0.609 0.268 0.311079019809 gnomAD-2.1.1 8.2E-06 None None None None N None 0 5.87E-05 None 0 0 None 0 None 0 0 0
E/G 32489 Fn3-124 91 rs987967114 0.154 -1.253 0.988 N 0.609 0.268 0.311079019809 gnomAD-4.0.0 3.19546E-06 None None None None N None 0 4.60172E-05 None 0 0 None 0 0 0 0 0
E/Q 32489 Fn3-124 91 None 0.1655 None 0.787 N 0.439 0.246 0.128392430309 gnomAD-4.0.0 4.79278E-06 None None None None N None 0 6.90131E-05 None 0 0 None 0 0 0 0 0
S/T 32589 Fn3-125 91 None 0.1241 None 0.997 N 0.619 0.102 0.192905019026 gnomAD-4.0.0 7.19355E-07 None None None None I None 0 0 None 0 0 None 0 0 9.34103E-07 0 0
P/L 32690 Fn3-126 91 rs1457945906 0.1431 -0.053 1.0 N 0.697 0.386 0.796323768304 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9E-06 0
P/S 32690 Fn3-126 91 rs1161513687 0.1467 -0.293 1.0 N 0.757 0.314 0.349429436713 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
P/S 32690 Fn3-126 91 rs1161513687 0.1467 -0.293 1.0 N 0.757 0.314 0.349429436713 gnomAD-4.0.0 1.60643E-06 None None None None N None 0 0 None 0 2.77731E-05 None 0 0 0 0 0
E/K 32885 Fn3-127 91 None 0.1035 None 0.919 N 0.525 0.132 0.252162846088 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
S/F 32987 Fn3-128 92 rs746380940 0.9829 -0.776 0.999 D 0.695 0.412 None gnomAD-2.1.1 8.96E-05 None None None None I None 0 5.67E-05 None 0 0 None 0 None 0 1.72826E-04 1.40964E-04
S/F 32987 Fn3-128 92 rs746380940 0.9829 -0.776 0.999 D 0.695 0.412 None gnomAD-3.1.2 1.44585E-04 None None None None I None 0 1.30993E-04 0 0 0 None 0 0 2.79346E-04 0 4.78011E-04
S/F 32987 Fn3-128 92 rs746380940 0.9829 -0.776 0.999 D 0.695 0.412 None gnomAD-4.0.0 1.29149E-04 None None None None I None 0 6.67379E-05 None 0 0 None 0 0 1.69053E-04 0 8.02723E-05
S/P 32987 Fn3-128 92 rs758494581 0.9921 0.099 0.999 N 0.562 0.532 None gnomAD-2.1.1 8.96E-05 None None None None I None 0 5.67E-05 None 0 0 None 0 None 0 1.72747E-04 1.40924E-04
S/P 32987 Fn3-128 92 rs758494581 0.9921 0.099 0.999 N 0.562 0.532 None gnomAD-3.1.2 1.44549E-04 None None None None I None 0 1.30959E-04 0 0 0 None 0 0 2.79297E-04 0 4.77555E-04
S/P 32987 Fn3-128 92 rs758494581 0.9921 0.099 0.999 N 0.562 0.532 None gnomAD-4.0.0 1.29121E-04 None None None None I None 0 6.67289E-05 None 0 0 None 0 0 1.69013E-04 0 8.02388E-05
A/G 33088 Fn3-129 91 rs745535102 0.2087 -0.04 0.682 N 0.561 0.337 0.495640347216 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 0 0
A/G 33088 Fn3-129 91 rs745535102 0.2087 -0.04 0.682 N 0.561 0.337 0.495640347216 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/G 33088 Fn3-129 91 rs745535102 0.2087 -0.04 0.682 N 0.561 0.337 0.495640347216 gnomAD-4.0.0 5.58015E-06 None None None None I None 0 0 None 0 0 None 0 0 1.69579E-06 6.59558E-05 1.60195E-05
S/F 33381 Fn3-130 92 None 0.3986 None 0.303 N 0.487 0.378 0.634884455959 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/P 33381 Fn3-130 92 None 0.0591 None None N 0.107 0.122 0.0297737177859 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/L 33777 Fn3-132 89 rs983842520 0.5114 None 0.948 N 0.678 0.378 0.596065454935 gnomAD-3.1.2 1.31E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 4.77555E-04
S/L 33777 Fn3-132 89 rs983842520 0.5114 None 0.948 N 0.678 0.378 0.596065454935 gnomAD-4.0.0 4.05978E-06 None None None None N None 0 6.15536E-05 None 0 0 None 0 0 2.40981E-06 0 3.40229E-05

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.