Structural position:

  • Domain Type: Fn3
  • Aligned Position: 127
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand G

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
V/I 15750 Fn3-1 94 rs72677232 0.0976 -0.387 0.994 N 0.631 0.206 None 1000 genomes 5.99042E-04 None None None None N None 0 0 None None 0 3E-03 None None None 0 None
V/I 15750 Fn3-1 94 rs72677232 0.0976 -0.387 0.994 N 0.631 0.206 None gnomAD-2.1.1 1.57552E-03 None None None None N None 6.2081E-04 1.41675E-04 None 0 0 None 0 None 1.2001E-03 3.00515E-03 9.85915E-04
V/I 15750 Fn3-1 94 rs72677232 0.0976 -0.387 0.994 N 0.631 0.206 None gnomAD-3.1.2 1.92898E-03 None None None None N None 5.07173E-04 1.31337E-04 3.94737E-02 0 0 None 6.5901E-04 0 3.34315E-03 0 0
V/I 15750 Fn3-1 94 rs72677232 0.0976 -0.387 0.994 N 0.631 0.206 None gnomAD-4.0.0 2.76944E-03 None None None None N None 4.53854E-04 1.83566E-04 None 3.38432E-05 0 None 1.00022E-03 0 3.59163E-03 0 1.36196E-03
V/L 15750 Fn3-1 94 None 0.4229 None 0.994 D 0.645 0.28 0.44859776 gnomAD-4.0.0 6.84655E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99896E-07 0 0
F/C 15850 Fn3-2 93 rs1462059025 0.2684 -0.461 0.855 N 0.502 0.31 0.47023726 gnomAD-2.1.1 5.65E-05 None None None None I None 0 3.77995E-04 None 0 0 None 0 None 0 0 1.66168E-04
F/C 15850 Fn3-2 93 rs1462059025 0.2684 -0.461 0.855 N 0.502 0.31 0.47023726 gnomAD-3.1.2 1.31662E-04 None None None None I None 0 1.24803E-03 0 0 0 None 0 0 0 0 4.78927E-04
F/C 15850 Fn3-2 93 rs1462059025 0.2684 -0.461 0.855 N 0.502 0.31 0.47023726 gnomAD-4.0.0 4.36394E-05 None None None None I None 0 5.60386E-04 None 0 0 None 0 0 0 0 2.85144E-05
F/L 15850 Fn3-2 93 rs113350914 0.7353 None 0.255 N 0.242 0.179 0.10462268 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 4.64E-05 0 0
F/L 15850 Fn3-2 93 rs113350914 0.7353 None 0.255 N 0.242 0.179 0.10462268 gnomAD-4.0.0 2.73929E-06 None None None None I None 8.98957E-05 0 None 0 0 None 0 0 0 0 1.65904E-05
F/S 15850 Fn3-2 93 rs1462059025 0.2823 -1.153 0.146 N 0.282 0.251 0.43602505 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
F/S 15850 Fn3-2 93 rs1462059025 0.2823 -1.153 0.146 N 0.282 0.251 0.43602505 gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
F/S 15850 Fn3-2 93 rs1462059025 0.2823 -1.153 0.146 N 0.282 0.251 0.43602505 gnomAD-4.0.0 3.85054E-06 None None None None I None 5.08337E-05 0 None 0 0 None 0 0 0 0 0
F/V 15850 Fn3-2 93 rs1183898794 0.205 -0.805 0.146 N 0.254 0.147 0.3946858 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 5.62E-05 None 0 None 0 0 0
F/V 15850 Fn3-2 93 rs1183898794 0.205 -0.805 0.146 N 0.254 0.147 0.3946858 gnomAD-4.0.0 1.5944E-06 None None None None I None 0 0 None 0 2.78365E-05 None 0 0 0 0 0
L/P 15952 Fn3-3 94 None 0.9302 None 0.999 D 0.876 0.437 0.7318638 gnomAD-4.0.0 1.20046E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07607E-05 0
L/V 15952 Fn3-3 94 rs2057492461 0.0913 None 0.429 N 0.347 0.114 0.1899582 gnomAD-4.0.0 1.37272E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80263E-06 0 0
V/I 16147 Fn3-4 93 None 0.0758 None 0.058 N 0.286 0.038 0.31501684 gnomAD-4.0.0 6.84739E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00071E-07 0 0
V/L 16147 Fn3-4 93 rs768269007 0.2013 0.055 0.802 N 0.577 0.092 0.26638564 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
V/L 16147 Fn3-4 93 rs768269007 0.2013 0.055 0.802 N 0.577 0.092 0.26638564 gnomAD-4.0.0 1.36948E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.32153E-05 0
I/M 16442 Fn3-6 92 None 0.126 None 0.39 N 0.41 0.065 0.36780393 gnomAD-4.0.0 6.84796E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16095E-05 0
I/V 16442 Fn3-6 92 rs2056850681 0.0612 None 0.39 N 0.424 0.068 0.3554503 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/T 16543 Fn3-7 94 rs753250455 0.7879 -2.654 0.682 D 0.683 0.403 0.55908227 gnomAD-2.1.1 1.44E-05 None None None None N None 0 0 None 0 2.09271E-04 None 0 None 0 0 0
I/T 16543 Fn3-7 94 rs753250455 0.7879 -2.654 0.682 D 0.683 0.403 0.55908227 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94704E-04 None 0 0 0 0 0
I/T 16543 Fn3-7 94 rs753250455 0.7879 -2.654 0.682 D 0.683 0.403 0.55908227 gnomAD-4.0.0 3.10441E-06 None None None None N None 0 0 None 0 1.12188E-04 None 0 0 0 0 0
I/V 16543 Fn3-7 94 rs756519277 0.084 -0.993 0.003 N 0.157 0.051 0.29278752 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 5.69E-05 None 0 None 0 0 0
I/V 16543 Fn3-7 94 rs756519277 0.084 -0.993 0.003 N 0.157 0.051 0.29278752 gnomAD-4.0.0 1.3712E-06 None None None None N None 0 0 None 0 2.53627E-05 None 0 0 9.0025E-07 0 0
V/L 16743 Fn3-9 93 None 0.5909 None 0.994 D 0.649 0.315 0.48330134 gnomAD-4.0.0 1.59407E-06 None None None None N None 0 0 None 0 2.79127E-05 None 0 0 0 0 0
V/M 16743 Fn3-9 93 None 0.5352 None 0.999 D 0.749 0.353 0.52866286 gnomAD-4.0.0 1.59407E-06 None None None None N None 0 0 None 0 2.79127E-05 None 0 0 0 0 0
L/P 16844 Fn3-10 94 rs764983586 0.9597 -1.074 0.994 N 0.846 0.314 0.7904742 gnomAD-2.1.1 2.83E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.25E-05 0
L/P 16844 Fn3-10 94 rs764983586 0.9597 -1.074 0.994 N 0.846 0.314 0.7904742 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.42E-05 0 0
L/P 16844 Fn3-10 94 rs764983586 0.9597 -1.074 0.994 N 0.846 0.314 0.7904742 gnomAD-4.0.0 1.73669E-05 None None None None N None 0 0 None 0 0 None 0 0 2.20508E-05 0 3.20585E-05
V/A 16946 Fn3-11 95 rs1179860102 0.4939 None 0.997 D 0.63 0.364 0.6476535 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
V/A 16946 Fn3-11 95 rs1179860102 0.4939 None 0.997 D 0.63 0.364 0.6476535 gnomAD-4.0.0 2.48026E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39181E-06 0 0
V/M 16946 Fn3-11 95 None 0.3781 None 0.999 D 0.712 0.332 0.56250244 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
V/L 17139 Fn3-12 93 rs758008217 0.3603 -0.369 0.056 N 0.47 0.07 0.21884543 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
V/L 17139 Fn3-12 93 rs758008217 0.3603 -0.369 0.056 N 0.47 0.07 0.21884543 gnomAD-4.0.0 7.53044E-06 None None None None N None 0 0 None 0 0 None 0 0 9.89778E-06 0 0
T/I 17240 Fn3-13 94 rs1295961462 0.0932 0.356 None N 0.346 0.096 0.20466535 gnomAD-2.1.1 4.14E-06 None None None None N None 0 0 None 0 0 None 3.48E-05 None 0 0 0
T/I 17240 Fn3-13 94 rs1295961462 0.0932 0.356 None N 0.346 0.096 0.20466535 gnomAD-4.0.0 4.14133E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.92403E-05 1.67235E-05
L/F 17462 Fn3-14 94 None 0.1417 None None N 0.303 0.064 0.08062527 gnomAD-4.0.0 3.19535E-06 None None None None N None 0 0 None 0 0 None 0 0 5.73247E-06 0 0
L/P 17462 Fn3-14 94 rs1216814159 0.9517 -1.168 0.303 N 0.729 0.307 0.627711 gnomAD-2.1.1 4.09E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.05E-06 0
L/P 17462 Fn3-14 94 rs1216814159 0.9517 -1.168 0.303 N 0.729 0.307 0.627711 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/P 17462 Fn3-14 94 rs1216814159 0.9517 -1.168 0.303 N 0.729 0.307 0.627711 gnomAD-4.0.0 8.06969E-06 None None None None N None 0 0 None 0 2.24689E-05 None 0 0 1.01807E-05 0 0
V/D 17661 Fn3-16 93 None 0.7704 None 0.981 N 0.857 0.244 0.6266655 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
I/N 17854 Fn3-17 91 rs375796420 0.9258 -1.673 0.994 N 0.901 0.475 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
I/N 17854 Fn3-17 91 rs375796420 0.9258 -1.673 0.994 N 0.901 0.475 None gnomAD-2.1.1 3.24E-05 None None None None N None 0 0 None 0 0 None 0 None 1.20048E-04 3.93E-05 1.41683E-04
I/N 17854 Fn3-17 91 rs375796420 0.9258 -1.673 0.994 N 0.901 0.475 None gnomAD-3.1.2 3.95E-05 None None None None N None 0 0 0 0 0 None 9.42E-05 0 5.89E-05 0 4.78011E-04
I/N 17854 Fn3-17 91 rs375796420 0.9258 -1.673 0.994 N 0.901 0.475 None gnomAD-4.0.0 1.67659E-05 None None None None N None 0 0 None 0 0 None 7.81274E-05 0 1.7817E-05 0 1.60483E-05
V/A 17955 Fn3-18 94 rs747319436 0.7781 None 0.996 N 0.552 0.179 0.58317745 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07383E-04 0
V/A 17955 Fn3-18 94 rs747319436 0.7781 None 0.996 N 0.552 0.179 0.58317745 gnomAD-4.0.0 3.91004E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.12394E-05 0
V/I 18158 Fn3-19 94 None 0.0895 None 0.003 N 0.284 0.064 0.32928213 gnomAD-4.0.0 1.37133E-06 None None None None N None 0 0 None 0 0 None 0 0 1.8014E-06 0 0
V/L 18158 Fn3-19 94 None 0.4049 None 0.046 N 0.412 0.123 0.43591583 gnomAD-4.0.0 6.85663E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16632E-05 0
E/A 18264 Fn3-20 99 None 0.0595 None None N 0.118 0.095 0.10462268 gnomAD-4.0.0 1.60669E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44329E-05 0
E/K 18264 Fn3-20 99 rs1253287416 0.272 -0.696 0.001 N 0.398 0.079 0.18692817 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
E/K 18264 Fn3-20 99 rs1253287416 0.272 -0.696 0.001 N 0.398 0.079 0.18692817 gnomAD-4.0.0 4.12128E-06 None None None None N None 0 0 None 0 0 None 0 0 5.41686E-06 0 0
E/Q 18264 Fn3-20 99 rs1253287416 0.1597 None 0.007 N 0.346 0.067 0.17258766 gnomAD-4.0.0 2.74752E-06 None None None None N None 0 0 None 0 2.53344E-05 None 0 0 9.02811E-07 1.16566E-05 1.6645E-05
I/S 18367 Fn3-21 96 rs758176369 0.5712 None 0.988 N 0.765 0.463 0.87596214 gnomAD-4.0.0 1.59366E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86225E-06 0 0
T/I 18571 Fn3-22 93 None 0.2307 None 0.728 N 0.552 0.177 0.32053947 gnomAD-4.0.0 2.1328E-06 None None None None N None 0 0 None 0 0 None 0 0 2.75815E-06 0 0
V/M 18677 Fn3-23 99 rs2053234064 0.1781 None None N None 0.114 None gnomAD-4.0.0 1.59354E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4339E-05 0
E/G 18876 Fn3-24 93 rs2052624292 0.4194 None 0.976 N 0.615 0.191 0.2994278 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 18876 Fn3-24 93 rs2052624292 0.4194 None 0.976 N 0.615 0.191 0.2994278 gnomAD-4.0.0 6.57419E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47067E-05 0 0
E/K 18876 Fn3-24 93 rs919241154 0.2155 None 0.954 N 0.481 0.185 0.25679356 gnomAD-4.0.0 3.69056E-06 None None None None N None 0 0 None 0 0 None 0 0 4.70007E-06 0 0
A/E 18981 Fn3-25 98 None 0.3356 None 0.065 N 0.623 0.082 0.11750665 gnomAD-4.0.0 1.36902E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79943E-06 0 0
A/P 18981 Fn3-25 98 rs760651904 0.9086 -0.197 0.162 N 0.645 0.089 0.16250381 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
A/P 18981 Fn3-25 98 rs760651904 0.9086 -0.197 0.162 N 0.645 0.089 0.16250381 gnomAD-4.0.0 6.84439E-07 None None None None N None 0 2.23794E-05 None 0 0 None 0 0 0 0 0
A/T 18981 Fn3-25 98 rs760651904 0.0659 -0.872 None N 0.246 0.119 0.08849929 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
A/T 18981 Fn3-25 98 rs760651904 0.0659 -0.872 None N 0.246 0.119 0.08849929 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
A/T 18981 Fn3-25 98 rs760651904 0.0659 -0.872 None N 0.246 0.119 0.08849929 gnomAD-4.0.0 3.09957E-06 None None None None N None 0 1.66834E-05 None 0 0 None 0 0 1.69567E-06 0 3.20318E-05
A/V 18981 Fn3-25 98 rs397517627 0.0465 0.146 None N 0.245 0.078 None gnomAD-2.1.1 1.1101E-04 None None None None N None 0 0 None 0 5.15E-05 None 0 None 0 2.27526E-04 1.40805E-04
A/V 18981 Fn3-25 98 rs397517627 0.0465 0.146 None N 0.245 0.078 None gnomAD-3.1.2 1.31529E-04 None None None None N None 2.41E-05 6.56E-05 0 0 0 None 0 0 2.64784E-04 0 0
A/V 18981 Fn3-25 98 rs397517627 0.0465 0.146 None N 0.245 0.078 None gnomAD-4.0.0 2.38073E-04 None None None None N None 1.33622E-05 1.66939E-05 None 0 0 None 0 0 3.18795E-04 0 9.60953E-05
I/T 19081 Fn3-26 94 rs78509062 0.1927 -2.528 0.976 N 0.657 0.294 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
I/T 19081 Fn3-26 94 rs78509062 0.1927 -2.528 0.976 N 0.657 0.294 None gnomAD-2.1.1 7.5E-05 None None None None N None 0 0 None 0 2.58318E-04 None 3.27E-05 None 0 1.17147E-04 0
I/T 19081 Fn3-26 94 rs78509062 0.1927 -2.528 0.976 N 0.657 0.294 None gnomAD-3.1.2 1.44625E-04 None None None None N None 4.83E-05 0 0 0 1.94024E-04 None 0 0 2.79387E-04 0 0
I/T 19081 Fn3-26 94 rs78509062 0.1927 -2.528 0.976 N 0.657 0.294 None gnomAD-4.0.0 1.63638E-04 None None None None N None 2.66624E-05 0 None 0 3.5775E-04 None 0 0 1.90748E-04 1.09842E-05 3.20215E-04
L/F 19276 Fn3-27 94 rs756493505 0.1397 -1.365 0.808 N 0.535 0.107 0.4304652 gnomAD-2.1.1 1.98E-05 None None None None N None 5.42E-05 3.75E-05 None 0 0 None 0 None 0 2.38E-05 0
L/F 19276 Fn3-27 94 rs756493505 0.1397 -1.365 0.808 N 0.535 0.107 0.4304652 gnomAD-3.1.2 1.98E-05 None None None None N None 4.87E-05 6.6E-05 0 0 0 None 0 0 0 0 0
L/F 19276 Fn3-27 94 rs756493505 0.1397 -1.365 0.808 N 0.535 0.107 0.4304652 gnomAD-4.0.0 5.77486E-06 None None None None N None 2.73373E-05 3.85446E-05 None 0 0 None 0 0 4.34527E-06 0 0
L/P 19276 Fn3-27 94 rs748582312 0.8159 -1.201 0.963 N 0.795 0.375 0.7983646 gnomAD-2.1.1 5.85E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.45E-05 0
L/P 19276 Fn3-27 94 rs748582312 0.8159 -1.201 0.963 N 0.795 0.375 0.7983646 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.78469E-04
L/P 19276 Fn3-27 94 rs748582312 0.8159 -1.201 0.963 N 0.795 0.375 0.7983646 gnomAD-4.0.0 1.9236E-06 None None None None N None 0 0 None 0 0 None 0 0 1.73788E-06 0 1.65328E-05
M/V 19571 Fn3-29 93 rs770228515 0.0625 -1.461 None N 0.149 0.276 0.35751903 gnomAD-2.1.1 8.11E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
M/V 19571 Fn3-29 93 rs770228515 0.0625 -1.461 None N 0.149 0.276 0.35751903 gnomAD-4.0.0 8.90388E-06 None None None None N None 0 0 None 0 0 None 0 0 1.07974E-05 0 1.65893E-05
V/A 19672 Fn3-30 94 rs1263299073 0.2907 -1.534 0.025 N 0.46 0.204 0.35628104 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
V/A 19672 Fn3-30 94 rs1263299073 0.2907 -1.534 0.025 N 0.46 0.204 0.35628104 gnomAD-4.0.0 1.59233E-06 None None None None N None 0 0 None 0 2.7818E-05 None 0 0 0 0 0
V/D 19672 Fn3-30 94 None 0.7759 None 0.303 N 0.703 0.441 0.6273466 gnomAD-4.0.0 1.59233E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43377E-05 0
V/D 19775 Fn3-31 96 rs2050514835 0.9217 None 0.999 D 0.829 0.493 0.8626132 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/D 19775 Fn3-31 96 rs2050514835 0.9217 None 0.999 D 0.829 0.493 0.8626132 gnomAD-4.0.0 6.57358E-06 None None None None N None 2.41243E-05 0 None 0 0 None 0 0 0 0 0
I/V 19969 Fn3-32 93 rs1232358158 0.066 -1.214 0.881 N 0.431 0.069 0.4396594 gnomAD-2.1.1 1.21E-05 None None None None N None 0 2.92E-05 None 0 0 None 0 None 4.65E-05 8.93E-06 0
I/V 19969 Fn3-32 93 rs1232358158 0.066 -1.214 0.881 N 0.431 0.069 0.4396594 gnomAD-4.0.0 3.42329E-06 None None None None N None 0 2.24296E-05 None 0 0 None 3.74784E-05 0 1.79945E-06 0 0
I/T 20067 Fn3-33 91 rs373690962 0.4988 -2.826 0.546 N 0.798 0.398 None gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 2.67E-05 0
I/T 20067 Fn3-33 91 rs373690962 0.4988 -2.826 0.546 N 0.798 0.398 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/T 20067 Fn3-33 91 rs373690962 0.4988 -2.826 0.546 N 0.798 0.398 None gnomAD-4.0.0 4.96079E-06 None None None None N None 0 0 None 0 4.46249E-05 None 0 0 5.08718E-06 0 0
T/A 20263 Fn3-34 93 rs886038850 0.0841 -0.441 0.058 N 0.314 0.167 0.11264884 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
T/A 20263 Fn3-34 93 rs886038850 0.0841 -0.441 0.058 N 0.314 0.167 0.11264884 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93874E-04 None 0 0 0 0 0
T/A 20263 Fn3-34 93 rs886038850 0.0841 -0.441 0.058 N 0.314 0.167 0.11264884 gnomAD-4.0.0 1.85968E-06 None None None None N None 0 0 None 0 4.46229E-05 None 0 0 8.47836E-07 0 0
V/M 20465 Fn3-36 95 rs1358181606 0.3856 None 0.999 N 0.721 0.294 0.26775503 gnomAD-3.1.2 2.63E-05 None None None None N None 0 6.56E-05 0 0 0 None 0 0 1.47E-05 0 9.59693E-04
V/M 20465 Fn3-36 95 rs1358181606 0.3856 None 0.999 N 0.721 0.294 0.26775503 gnomAD-4.0.0 2.63071E-05 None None None None N None 0 6.56254E-05 None 0 0 None 0 0 1.47076E-05 0 9.59693E-04
V/L 21056 Fn3-40 94 None 0.2117 None 0.278 N 0.471 0.195 0.37657037 gnomAD-4.0.0 7.24987E-07 None None None None N None 0 0 None 0 0 None 0 0 9.30125E-07 0 0
V/M 21056 Fn3-40 94 None 0.1394 None 0.93 N 0.547 0.217 0.46375853 gnomAD-4.0.0 2.17496E-06 None None None None N None 0 0 None 0 0 None 0 0 1.86025E-06 0 1.76199E-05
V/M 21358 Fn3-42 93 rs371725212 0.1677 -0.419 0.808 N 0.647 0.097 None gnomAD-2.1.1 3.22E-05 None None None None N None 0 0 None 0 0 None 0 None 0 7.11E-05 0
V/M 21358 Fn3-42 93 rs371725212 0.1677 -0.419 0.808 N 0.647 0.097 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
V/M 21358 Fn3-42 93 rs371725212 0.1677 -0.419 0.808 N 0.647 0.097 None gnomAD-4.0.0 2.17963E-05 None None None None N None 0 0 None 0 0 None 1.56946E-05 0 3.83245E-05 0 0
M/R 21651 Fn3-44 93 rs2048549278 0.5602 None 0.976 N 0.57 0.275 0.60452765 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
M/R 21651 Fn3-44 93 rs2048549278 0.5602 None 0.976 N 0.57 0.275 0.60452765 gnomAD-4.0.0 6.57635E-06 None None None None N None 2.41289E-05 0 None 0 0 None 0 0 0 0 0
M/T 21651 Fn3-44 93 rs2048549278 0.3761 None 0.651 N 0.513 0.251 0.69229543 gnomAD-4.0.0 1.36869E-06 None None None None N None 5.9805E-05 0 None 0 0 None 0 0 0 0 0
V/L 21752 Fn3-45 94 None 0.3379 None 0.506 N 0.417 0.206 0.5682855 gnomAD-4.0.0 1.04784E-05 None None None None N None 0 0 None 0 0 None 0 0 1.37055E-05 0 0
A/S 22047 Fn3-47 92 None 0.1222 None 0.361 N 0.54 0.082 0.29132393 gnomAD-4.0.0 1.65944E-06 None None None None N None 0 0 None 0 0 None 1.89689E-05 0 0 0 0
A/T 22148 Fn3-48 94 rs794727433 0.088 -0.72 0.396 D 0.485 0.138 0.35772473 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 2.81025E-04 None 0 None 0 0 0
A/T 22148 Fn3-48 94 rs794727433 0.088 -0.72 0.396 D 0.485 0.138 0.35772473 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.93798E-04 None 0 0 0 0 0
A/T 22148 Fn3-48 94 rs794727433 0.088 -0.72 0.396 D 0.485 0.138 0.35772473 gnomAD-4.0.0 9.91907E-06 None None None None N None 0 0 None 0 2.01288E-04 None 0 0 5.08704E-06 0 1.602E-05
H/Q 22250 Fn3-49 95 rs928913814 0.3952 -1.614 0.999 D 0.775 0.233 0.4977418 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14732E-04 0 None 0 0 None 0 None 0 0 0
H/Q 22250 Fn3-49 95 rs928913814 0.3952 -1.614 0.999 D 0.775 0.233 0.4977418 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
H/Q 22250 Fn3-49 95 rs928913814 0.3952 -1.614 0.999 D 0.775 0.233 0.4977418 gnomAD-4.0.0 4.99094E-06 None None None None N None 1.33815E-05 0 None 0 0 None 0 0 5.96897E-06 0 0
V/A 22446 Fn3-50 93 rs751361453 0.3299 -1.439 0.997 N 0.683 0.379 0.5328909 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 9.98E-05 0 None 0 None 0 0 0
V/I 22446 Fn3-50 93 rs113934347 0.084 None 0.994 N 0.659 0.143 0.49295297 gnomAD-4.0.0 1.36899E-06 None None None None N None 2.99097E-05 0 None 0 0 None 0 0 0 0 1.65761E-05
V/L 22446 Fn3-50 93 None 0.2898 None 0.994 N 0.662 0.202 0.4395518 gnomAD-4.0.0 6.84495E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99687E-07 0 0
V/A 22539 Fn3-51 89 rs1553622176 0.1459 None None N 0.238 0.101 0.30983967 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/F 22539 Fn3-51 89 rs558955595 0.2276 -1.111 None N 0.329 0.067 0.38140905 gnomAD-2.1.1 4.04E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
V/F 22539 Fn3-51 89 rs558955595 0.2276 -1.111 None N 0.329 0.067 0.38140905 gnomAD-4.0.0 6.84421E-07 None None None None N None 2.99043E-05 0 None 0 0 None 0 0 0 0 0
V/I 22539 Fn3-51 89 rs558955595 0.0966 -0.352 None N 0.197 0.041 0.21200892 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
V/I 22539 Fn3-51 89 rs558955595 0.0966 -0.352 None N 0.197 0.041 0.21200892 gnomAD-2.1.1 2.87E-05 None None None None N None 2.89424E-04 0 None 0 0 None 3.27E-05 None 0 0 0
V/I 22539 Fn3-51 89 rs558955595 0.0966 -0.352 None N 0.197 0.041 0.21200892 gnomAD-3.1.2 7.89E-05 None None None None N None 2.89533E-04 0 0 0 0 None 0 0 0 0 0
V/I 22539 Fn3-51 89 rs558955595 0.0966 -0.352 None N 0.197 0.041 0.21200892 gnomAD-4.0.0 1.54964E-05 None None None None N None 2.93302E-04 0 None 0 0 None 0 0 8.47837E-07 1.09806E-05 1.60118E-05
I/F 22735 Fn3-52 93 rs2154174995 0.2175 None 0.314 N 0.508 0.182 0.48034996 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.78927E-04
I/F 22735 Fn3-52 93 rs2154174995 0.2175 None 0.314 N 0.508 0.182 0.48034996 gnomAD-4.0.0 6.57099E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 4.73934E-04
V/A 22836 Fn3-53 94 rs777547127 0.1907 -1.891 0.005 N 0.271 0.121 0.5188053 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
V/A 22836 Fn3-53 94 rs777547127 0.1907 -1.891 0.005 N 0.271 0.121 0.5188053 gnomAD-4.0.0 4.10718E-06 None None None None N None 2.99133E-05 0 None 0 0 None 0 0 4.49863E-06 0 0
V/F 22836 Fn3-53 94 rs1422284948 0.2275 None 0.933 N 0.8 0.163 0.66704714 gnomAD-4.0.0 6.84542E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9974E-07 0 0
V/I 22836 Fn3-53 94 rs1422284948 0.079 None 0.451 N 0.645 0.132 0.39559507 gnomAD-4.0.0 3.42271E-06 None None None None N None 0 0 None 0 0 None 0 1.73853E-04 0 4.64339E-05 0
I/N 22935 Fn3-54 95 rs971232021 0.5982 -2.182 0.57 N 0.747 0.451 0.8019328 gnomAD-2.1.1 4.1E-06 None None None None N None 6.5E-05 0 None 0 0 None 0 None 0 0 0
I/N 22935 Fn3-54 95 rs971232021 0.5982 -2.182 0.57 N 0.747 0.451 0.8019328 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/N 22935 Fn3-54 95 rs971232021 0.5982 -2.182 0.57 N 0.747 0.451 0.8019328 gnomAD-4.0.0 3.87447E-06 None None None None N None 3.39824E-05 0 None 0 2.43736E-05 None 0 0 0 0 0
V/I 23131 Fn3-55 92 None 0.0846 None 0.049 N 0.289 0.076 0.39724302 gnomAD-4.0.0 2.74301E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70259E-06 1.16618E-05 0
V/A 23232 Fn3-56 94 rs1575819357 0.262 None 0.952 N 0.547 0.204 0.47936362 gnomAD-4.0.0 3.18409E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86854E-05 0
V/L 23232 Fn3-56 94 rs1195674859 0.2208 -0.188 0.802 N 0.557 0.186 0.32139316 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
V/L 23232 Fn3-56 94 rs1195674859 0.2208 -0.188 0.802 N 0.557 0.186 0.32139316 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 4.78011E-04
V/L 23232 Fn3-56 94 rs1195674859 0.2208 -0.188 0.802 N 0.557 0.186 0.32139316 gnomAD-4.0.0 5.57866E-06 None None None None N None 1.33522E-05 0 None 0 0 None 0 0 5.0864E-06 0 3.20307E-05
V/I 23527 Fn3-58 93 rs542004766 0.0711 -0.358 None N 0.123 0.047 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
V/I 23527 Fn3-58 93 rs542004766 0.0711 -0.358 None N 0.123 0.047 None gnomAD-2.1.1 4.64E-05 None None None None N None 1.65358E-04 5.65E-05 None 0 0 None 3.27E-05 None 0 4.7E-05 0
V/I 23527 Fn3-58 93 rs542004766 0.0711 -0.358 None N 0.123 0.047 None gnomAD-3.1.2 5.92E-05 None None None None N None 9.65E-05 1.31044E-04 0 0 0 None 0 0 4.41E-05 0 0
V/I 23527 Fn3-58 93 rs542004766 0.0711 -0.358 None N 0.123 0.047 None gnomAD-4.0.0 2.60283E-05 None None None None N None 9.3301E-05 6.66622E-05 None 0 0 None 0 0 1.86498E-05 5.49028E-05 6.40266E-05
V/L 23527 Fn3-58 93 rs542004766 0.2428 -0.361 None N 0.219 0.053 0.3173784 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
V/L 23527 Fn3-58 93 rs542004766 0.2428 -0.361 None N 0.219 0.053 0.3173784 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/L 23527 Fn3-58 93 rs542004766 0.2428 -0.361 None N 0.219 0.053 0.3173784 gnomAD-4.0.0 2.47907E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39084E-06 0 0
V/A 23622 Fn3-59 91 None 0.4938 None 0.014 N 0.293 0.208 0.33187607 gnomAD-4.0.0 3.18454E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8595E-06 1.43291E-05 0
V/I 23622 Fn3-59 91 rs72646892 0.0947 -0.066 0.007 N 0.294 0.045 None gnomAD-2.1.1 4.03E-05 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 8.02E-05 0
V/I 23622 Fn3-59 91 rs72646892 0.0947 -0.066 0.007 N 0.294 0.045 None gnomAD-3.1.2 8.55E-05 None None None None N None 0 0 5.48246E-03 0 1.93723E-04 None 0 0 1.02974E-04 0 0
V/I 23622 Fn3-59 91 rs72646892 0.0947 -0.066 0.007 N 0.294 0.045 None gnomAD-4.0.0 4.09147E-05 None None None None N None 1.33533E-05 1.66778E-05 None 0 4.47989E-05 None 0 0 4.40845E-05 2.1964E-05 4.80538E-05
I/T 23818 Fn3-60 93 rs749803403 0.1808 -2.051 0.03 N 0.546 0.246 0.63530487 gnomAD-2.1.1 7.16E-05 None None None None N None 0 0 None 0 9.7918E-04 None 3.28E-05 None 0 0 0
I/T 23818 Fn3-60 93 rs749803403 0.1808 -2.051 0.03 N 0.546 0.246 0.63530487 gnomAD-3.1.2 4.6E-05 None None None None N None 0 0 0 0 1.35712E-03 None 0 0 0 0 0
I/T 23818 Fn3-60 93 rs749803403 0.1808 -2.051 0.03 N 0.546 0.246 0.63530487 gnomAD-4.0.0 3.65736E-05 None None None None N None 0 1.66817E-05 None 0 1.25061E-03 None 0 0 8.47775E-07 1.09885E-05 0
I/V 23818 Fn3-60 93 rs776911847 0.0557 -0.852 None N 0.111 0.056 0.11007815 gnomAD-2.1.1 8.23E-05 None None None None N None 0 2.83E-05 None 0 0 None 6.55E-05 None 4.01E-05 1.48723E-04 0
I/V 23818 Fn3-60 93 rs776911847 0.0557 -0.852 None N 0.111 0.056 0.11007815 gnomAD-3.1.2 7.23E-05 None None None None N None 0 0 0 0 0 None 0 0 1.6176E-04 0 0
I/V 23818 Fn3-60 93 rs776911847 0.0557 -0.852 None N 0.111 0.056 0.11007815 gnomAD-4.0.0 3.5331E-05 None None None None N None 1.33291E-05 1.66728E-05 None 0 0 None 3.12529E-05 1.65289E-04 4.0693E-05 2.198E-05 3.20215E-05
M/R 23919 Fn3-61 94 rs769164762 0.1032 -1.076 0.026 N 0.632 0.049 0.25729233 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
M/T 23919 Fn3-61 94 None 0.0709 None None N 0.355 0.075 0.3689342 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
M/V 23919 Fn3-61 94 rs777077373 0.0512 -1.092 None N 0.121 0.103 0.07629995 gnomAD-2.1.1 1.21E-05 None None None None N None 0 2.9E-05 None 9.95E-05 0 None 0 None 0 8.89E-06 0
M/V 23919 Fn3-61 94 rs777077373 0.0512 -1.092 None N 0.121 0.103 0.07629995 gnomAD-4.0.0 3.42137E-06 None None None None N None 0 2.23634E-05 None 0 2.52054E-05 None 0 0 1.79909E-06 0 1.65667E-05
I/S 24018 Fn3-62 95 None 0.8985 None 0.997 N 0.764 0.517 0.7155843 gnomAD-4.0.0 1.59218E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86041E-06 0 0
I/T 24018 Fn3-62 95 rs753170264 0.7855 -2.219 0.976 N 0.696 0.358 0.49362874 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
I/T 24018 Fn3-62 95 rs753170264 0.7855 -2.219 0.976 N 0.696 0.358 0.49362874 gnomAD-4.0.0 1.59218E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86041E-06 0 0
I/V 24018 Fn3-62 95 None 0.0754 None 0.188 N 0.151 0.077 0.3176678 gnomAD-4.0.0 1.36874E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79934E-06 0 0
V/L 24214 Fn3-63 93 None 0.1331 None 0.002 N 0.331 0.125 0.32278606 gnomAD-4.0.0 7.406E-07 None None None None N None 3.34986E-05 0 None 0 0 None 0 0 0 0 0
Y/H 24315 Fn3-64 94 rs794729492 0.1799 -0.646 0.998 N 0.666 0.382 0.4304652 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.99E-06 0
Y/H 24315 Fn3-64 94 rs794729492 0.1799 -0.646 0.998 N 0.666 0.382 0.4304652 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Y/H 24315 Fn3-64 94 rs794729492 0.1799 -0.646 0.998 N 0.666 0.382 0.4304652 gnomAD-4.0.0 2.48403E-06 None None None None N None 0 0 None 0 0 None 0 0 3.3963E-06 0 0
V/L 24611 Fn3-66 93 rs760865833 0.2658 -0.169 0.044 N 0.392 0.177 0.41720825 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
V/L 24611 Fn3-66 93 rs760865833 0.2658 -0.169 0.044 N 0.392 0.177 0.41720825 gnomAD-4.0.0 2.05521E-06 None None None None N None 2.9915E-05 0 None 0 0 None 0 0 1.80123E-06 0 0
V/M 24611 Fn3-66 93 None 0.1966 -0.394 0.939 N 0.597 0.284 0.53572685 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
V/M 24611 Fn3-66 93 None 0.1966 -0.394 0.939 N 0.597 0.284 0.53572685 gnomAD-4.0.0 1.37014E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80123E-06 0 0
V/A 24707 Fn3-67 92 None 0.7235 None 0.999 D 0.66 0.379 0.6229596 gnomAD-4.0.0 1.36887E-06 None None None None N None 0 0 None 0 2.53049E-05 None 1.87406E-05 0 0 0 0
V/E 24707 Fn3-67 92 rs780299418 0.9758 None 0.999 D 0.89 0.542 0.78323203 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/E 24707 Fn3-67 92 rs780299418 0.9758 None 0.999 D 0.89 0.542 0.78323203 gnomAD-4.0.0 1.23978E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69552E-06 0 0
V/M 24707 Fn3-67 92 rs2154169785 0.4648 None 1.0 D 0.657 0.333 0.57200176 gnomAD-4.0.0 1.59249E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85971E-06 0 0
T/A 24900 Fn3-68 93 None 0.0705 None 0.001 N 0.201 0.116 0.029773718 gnomAD-4.0.0 1.59189E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
I/V 25100 Fn3-70 95 rs1314990516 0.0842 -0.919 0.003 N 0.136 0.128 0.15110473 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
I/V 25100 Fn3-70 95 rs1314990516 0.0842 -0.919 0.003 N 0.136 0.128 0.15110473 gnomAD-4.0.0 2.05288E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69869E-06 0 0
V/A 25296 Fn3-71 93 rs765266847 0.1519 -1.658 0.025 N 0.401 0.308 0.5271995 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 1.66334E-04
V/A 25296 Fn3-71 93 rs765266847 0.1519 -1.658 0.025 N 0.401 0.308 0.5271995 gnomAD-4.0.0 3.42179E-06 None None None None N None 0 0 None 0 0 None 0 1.73551E-04 1.79914E-06 0 3.31455E-05
V/G 25296 Fn3-71 93 rs765266847 0.3716 -2.216 0.303 D 0.697 0.5 0.67388546 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
V/G 25296 Fn3-71 93 rs765266847 0.3716 -2.216 0.303 D 0.697 0.5 0.67388546 gnomAD-4.0.0 6.84358E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9957E-07 0 0
I/L 25499 Fn3-73 95 None 0.1233 None 0.012 N 0.393 0.041 0.048227955 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/N 25693 Fn3-74 93 None 0.4423 None 0.57 N 0.726 0.441 0.7762135 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/T 25693 Fn3-74 93 None 0.228 None 0.03 N 0.526 0.302 0.473301 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
I/V 25693 Fn3-74 93 rs765718348 0.0516 -0.946 None N 0.113 0.144 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/V 25693 Fn3-74 93 rs765718348 0.0516 -0.946 None N 0.113 0.144 None gnomAD-4.0.0 3.42205E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59855E-06 1.1602E-05 0
I/L 25789 Fn3-75 92 rs1253687329 0.2297 None None N 0.219 0.052 0.31531405 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 25789 Fn3-75 92 rs1253687329 0.057 None None N 0.155 0.05 0.3144173 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/N 25982 Fn3-76 93 rs760050553 0.6187 None 0.162 N 0.599 0.363 0.72440845 gnomAD-4.0.0 6.84291E-07 None None None None N None 0 0 None 0 0 None 0 1.73551E-04 0 0 0
I/T 25982 Fn3-76 93 rs760050553 0.1413 -2.089 0.006 N 0.378 0.287 0.63861847 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/T 25982 Fn3-76 93 rs760050553 0.1413 -2.089 0.006 N 0.378 0.287 0.63861847 gnomAD-3.1.2 1.32E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 25982 Fn3-76 93 rs760050553 0.1413 -2.089 0.006 N 0.378 0.287 0.63861847 gnomAD-4.0.0 1.05367E-05 None None None None N None 6.67967E-05 0 None 0 6.68777E-05 None 0 0 4.23876E-06 4.39165E-05 0
I/V 25982 Fn3-76 93 None 0.0458 None None N 0.115 0.06 0.15110473 gnomAD-4.0.0 1.59171E-06 None None None None N None 0 0 None 0 2.77331E-05 None 0 0 0 0 0
Y/C 26083 Fn3-77 94 rs910116004 0.0785 -0.692 0.034 N 0.513 0.26 0.4169563 gnomAD-2.1.1 7.14E-06 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 0 0
Y/C 26083 Fn3-77 94 rs910116004 0.0785 -0.692 0.034 N 0.513 0.26 0.4169563 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
Y/C 26083 Fn3-77 94 rs910116004 0.0785 -0.692 0.034 N 0.513 0.26 0.4169563 gnomAD-4.0.0 3.71872E-06 None None None None N None 8.01175E-05 0 None 0 0 None 0 0 0 0 0
I/V 26182 Fn3-78 95 None 0.0693 None 0.005 N 0.181 0.092 0.23057862 gnomAD-4.0.0 2.05771E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70366E-06 0 0
V/I 26378 Fn3-79 93 rs1476994621 0.0788 -0.547 0.994 N 0.693 0.241 0.3548224 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
V/I 26378 Fn3-79 93 rs1476994621 0.0788 -0.547 0.994 N 0.693 0.241 0.3548224 gnomAD-4.0.0 1.36855E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99551E-07 1.15934E-05 0
Y/C 26479 Fn3-80 94 None 0.1074 None 0.993 N 0.508 0.263 0.60192305 gnomAD-4.0.0 1.59216E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85896E-06 0 0
Y/F 26479 Fn3-80 94 rs747150576 0.0867 -0.485 0.002 N 0.187 0.163 0.29491836 gnomAD-2.1.1 4.03E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
Y/F 26479 Fn3-80 94 rs747150576 0.0867 -0.485 0.002 N 0.187 0.163 0.29491836 gnomAD-4.0.0 1.59216E-06 None None None None I None 5.65803E-05 0 None 0 0 None 0 0 0 0 0
V/G 26581 Fn3-81 95 None 0.291 None 0.994 N 0.793 0.511 0.7657235 gnomAD-4.0.0 1.59183E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85884E-06 0 0
V/M 26581 Fn3-81 95 None 0.1521 None 0.961 N 0.69 0.255 0.5308031 gnomAD-4.0.0 1.59189E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85884E-06 0 0
V/M 26775 Fn3-82 93 rs370589806 0.1763 -0.247 0.979 N 0.577 0.221 None gnomAD-2.1.1 8.05E-06 None None None None N None 6.46E-05 2.9E-05 None 0 0 None 0 None 0 0 0
V/M 26775 Fn3-82 93 rs370589806 0.1763 -0.247 0.979 N 0.577 0.221 None gnomAD-3.1.2 3.95E-05 None None None None N None 2.41E-05 1.96825E-04 0 0 0 None 0 0 2.94E-05 0 0
V/M 26775 Fn3-82 93 rs370589806 0.1763 -0.247 0.979 N 0.577 0.221 None gnomAD-4.0.0 8.67686E-06 None None None None N None 5.34259E-05 6.67089E-05 None 0 0 None 0 1.64582E-04 4.2385E-06 0 0
V/I 26871 Fn3-83 92 None 0.1048 None 0.984 N 0.547 0.272 0.5436914 gnomAD-4.0.0 2.05302E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99603E-07 0 3.31422E-05
V/D 27064 Fn3-84 93 rs1705136548 0.891 None 0.747 N 0.835 0.407 0.81440145 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 27064 Fn3-84 93 rs1299204820 0.074 -0.423 0.003 N 0.241 0.031 0.24107899 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
V/I 27064 Fn3-84 93 rs1299204820 0.074 -0.423 0.003 N 0.241 0.031 0.24107899 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
F/S 27165 Fn3-85 94 rs1413349026 0.3165 None 0.006 N 0.343 0.061 0.43023992 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
F/S 27165 Fn3-85 94 rs1413349026 0.3165 None 0.006 N 0.343 0.061 0.43023992 gnomAD-4.0.0 6.57393E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47046E-05 0 0
I/L 27264 Fn3-86 95 None 0.3112 None 0.985 N 0.404 0.205 0.4578315 gnomAD-4.0.0 1.59143E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
I/V 27264 Fn3-86 95 rs1704855362 0.0859 None 0.985 N 0.355 0.183 0.5375882 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.41E-05 0 0 0 0
I/V 27264 Fn3-86 95 rs1704855362 0.0859 None 0.985 N 0.355 0.183 0.5375882 gnomAD-4.0.0 2.56236E-06 None None None None N None 0 0 None 0 0 None 3.13824E-05 0 0 0 0
V/D 27461 Fn3-87 93 None 0.7865 None 0.808 D 0.831 0.354 0.80851 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 27461 Fn3-87 93 None 0.0734 None 0.004 N 0.305 0.021 0.29132393 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Y/H 27562 Fn3-88 94 rs376616067 0.1909 -0.678 0.303 N 0.524 0.193 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
Y/H 27562 Fn3-88 94 rs376616067 0.1909 -0.678 0.303 N 0.524 0.193 None gnomAD-2.1.1 1.00102E-04 None None None None N None 9.09993E-04 1.41563E-04 None 0 0 None 0 None 0 7.83E-06 0
Y/H 27562 Fn3-88 94 rs376616067 0.1909 -0.678 0.303 N 0.524 0.193 None gnomAD-3.1.2 3.15657E-04 None None None None N None 1.08664E-03 6.56E-05 0 0 0 None 0 0 0 0 9.56023E-04
Y/H 27562 Fn3-88 94 rs376616067 0.1909 -0.678 0.303 N 0.524 0.193 None gnomAD-4.0.0 5.94933E-05 None None None None N None 9.59949E-04 1.33373E-04 None 0 0 None 0 0 7.62885E-06 0 1.12047E-04
V/A 27858 Fn3-90 93 rs1704088827 0.3196 None 0.411 N 0.519 0.287 0.4705665 gnomAD-4.0.0 1.59849E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86722E-06 0 0
V/I 27858 Fn3-90 93 rs778221988 0.0695 -0.252 0.002 N 0.191 0.03 None gnomAD-2.1.1 5.41E-05 None None None None N None 1.6581E-04 0 None 0 0 None 0 None 0 8.65E-05 0
V/I 27858 Fn3-90 93 rs778221988 0.0695 -0.252 0.002 N 0.191 0.03 None gnomAD-3.1.2 2.63E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 2.94E-05 0 0
V/I 27858 Fn3-90 93 rs778221988 0.0695 -0.252 0.002 N 0.191 0.03 None gnomAD-4.0.0 1.56472E-04 None None None None N None 1.07035E-04 1.67808E-05 None 0 0 None 0 0 2.02787E-04 0 6.4156E-05
V/I 27954 Fn3-91 92 None 0.1023 None 0.984 D 0.582 0.221 0.7078177 gnomAD-4.0.0 6.84384E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99569E-07 0 0
V/L 27954 Fn3-91 92 rs1703951174 0.5829 None 0.984 N 0.631 0.322 0.6476882 gnomAD-4.0.0 6.84384E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99569E-07 0 0
V/A 28146 Fn3-92 92 rs755354570 0.2397 -0.764 0.682 N 0.492 0.369 0.6306324 gnomAD-2.1.1 1.09E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.37E-05 0
V/A 28146 Fn3-92 92 rs755354570 0.2397 -0.764 0.682 N 0.492 0.369 0.6306324 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
V/A 28146 Fn3-92 92 rs755354570 0.2397 -0.764 0.682 N 0.492 0.369 0.6306324 gnomAD-4.0.0 3.29632E-05 None None None None N None 0 0 None 0 0 None 0 0 4.25177E-05 0 4.82191E-05
V/I 28146 Fn3-92 92 rs371366196 0.074 -0.393 0.007 N 0.205 0.027 None gnomAD-2.1.1 4.7E-05 None None None None N None 0 2.86E-05 None 0 0 None 0 None 0 8.7E-05 1.42572E-04
V/I 28146 Fn3-92 92 rs371366196 0.074 -0.393 0.007 N 0.205 0.027 None gnomAD-3.1.2 5.26E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 8.82E-05 0 4.77555E-04
V/I 28146 Fn3-92 92 rs371366196 0.074 -0.393 0.007 N 0.205 0.027 None gnomAD-4.0.0 7.02819E-05 None None None None N None 0 3.35289E-05 None 0 0 None 0 1.65289E-04 8.75816E-05 0 1.12544E-04
I/L 28346 Fn3-94 95 rs912296403 0.2095 None 0.162 N 0.376 0.045 0.33689228 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/L 28346 Fn3-94 95 rs912296403 0.2095 None 0.162 N 0.376 0.045 0.33689228 gnomAD-4.0.0 2.02992E-06 None None None None N None 1.74727E-05 0 None 0 0 None 0 0 1.20492E-06 0 0
I/N 28346 Fn3-94 95 None 0.8826 None 0.979 N 0.833 0.463 0.78391993 gnomAD-4.0.0 1.59113E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85799E-06 0 0
I/L 28542 Fn3-95 93 rs554841820 0.1202 -0.662 0.001 N 0.351 0.054 0.43559027 gnomAD-2.1.1 8.08E-06 None None None None N None 0 0 None 0 1.1217E-04 None 0 None 0 0 0
I/L 28542 Fn3-95 93 rs554841820 0.1202 -0.662 0.001 N 0.351 0.054 0.43559027 gnomAD-4.0.0 2.73811E-06 None None None None N None 0 0 None 0 1.01056E-04 None 0 0 0 0 0
I/V 28542 Fn3-95 93 rs554841820 0.0512 -1.106 None N 0.125 0.056 0.2292643 1000 genomes 3.99361E-04 None None None None N None 0 2.9E-03 None None 0 0 None None None 0 None
I/V 28542 Fn3-95 93 rs554841820 0.0512 -1.106 None N 0.125 0.056 0.2292643 gnomAD-2.1.1 1.21E-05 None None None None N None 0 5.82E-05 None 0 0 None 0 None 0 8.92E-06 0
I/V 28542 Fn3-95 93 rs554841820 0.0512 -1.106 None N 0.125 0.056 0.2292643 gnomAD-3.1.2 3.29E-05 None None None None N None 0 3.27869E-04 0 0 0 None 0 0 0 0 0
I/V 28542 Fn3-95 93 rs554841820 0.0512 -1.106 None N 0.125 0.056 0.2292643 gnomAD-4.0.0 1.11587E-05 None None None None N None 0 2.3352E-04 None 0 8.93775E-05 None 0 0 0 0 0
Q/R 28743 Fn3-97 93 None 0.1535 None 0.651 N 0.498 0.143 0.18692817 gnomAD-4.0.0 4.79018E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29649E-06 0 0
V/I 28937 Fn3-98 93 rs794727453 0.0647 None None N 0.194 0.084 0.41337362 gnomAD-3.1.2 3.29E-05 None None None None N None 1.20633E-04 0 0 0 0 None 0 0 0 0 0
V/I 28937 Fn3-98 93 rs794727453 0.0647 None None N 0.194 0.084 0.41337362 gnomAD-4.0.0 7.9363E-06 None None None None N None 1.0376E-04 0 None 0 0 None 0 0 0 0 0
V/F 29033 Fn3-99 92 None 0.3136 None 1.0 N 0.817 0.419 0.74980474 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 29330 Fn3-101 94 rs1701877919 0.3797 None 0.997 N 0.676 0.333 0.6041627 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 3.66327E-05
I/V 29429 Fn3-102 95 rs373738818 0.0537 -1.168 None N 0.188 0.07 None gnomAD-2.1.1 5.72E-05 None None None None N None 4.13E-05 0 None 0 0 None 0 None 4.01E-05 1.09519E-04 0
I/V 29429 Fn3-102 95 rs373738818 0.0537 -1.168 None N 0.188 0.07 None gnomAD-3.1.2 8.54E-05 None None None None N None 0 0 0 0 0 None 9.41E-05 0 1.76372E-04 0 0
I/V 29429 Fn3-102 95 rs373738818 0.0537 -1.168 None N 0.188 0.07 None gnomAD-4.0.0 1.23326E-04 None None None None N None 1.33437E-05 0 None 0 0 None 3.12999E-05 0 1.54261E-04 0 2.24143E-04
V/A 29625 Fn3-103 93 rs975051057 0.2697 -1.644 0.988 N 0.544 0.32 0.5567728 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 8.92E-06 0
V/A 29625 Fn3-103 93 rs975051057 0.2697 -1.644 0.988 N 0.544 0.32 0.5567728 gnomAD-3.1.2 1.97E-05 None None None None N None 4.82E-05 0 0 0 0 None 9.41E-05 0 0 0 0
V/A 29625 Fn3-103 93 rs975051057 0.2697 -1.644 0.988 N 0.544 0.32 0.5567728 gnomAD-4.0.0 6.40801E-06 None None None None N None 5.07271E-05 0 None 0 0 None 1.56961E-05 0 2.39341E-06 0 0
V/I 29625 Fn3-103 93 rs764499992 0.0725 0.143 0.756 N 0.181 0.214 0.40803686 gnomAD-2.1.1 1.08E-05 None None None None N None 0 0 None 0 1.55055E-04 None 0 None 0 0 0
V/I 29625 Fn3-103 93 rs764499992 0.0725 0.143 0.756 N 0.181 0.214 0.40803686 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 3.85208E-04 None 0 0 0 0 0
V/I 29625 Fn3-103 93 rs764499992 0.0725 0.143 0.756 N 0.181 0.214 0.40803686 gnomAD-4.0.0 3.09925E-06 None None None None N None 0 0 None 0 4.46927E-05 None 0 0 1.69538E-06 0 1.60159E-05
Y/C 29726 Fn3-104 94 rs1348960707 0.0922 0.036 0.997 N 0.807 0.27 0.5714144 gnomAD-2.1.1 4.18E-06 None None None None N None 0 2.96E-05 None 0 0 None 0 None 0 0 0
Y/C 29726 Fn3-104 94 rs1348960707 0.0922 0.036 0.997 N 0.807 0.27 0.5714144 gnomAD-4.0.0 1.62179E-06 None None None None N None 0 2.3284E-05 None 0 0 None 0 0 0 0 0
Y/H 29726 Fn3-104 94 None 0.1559 None 0.989 N 0.628 0.356 0.41531363 gnomAD-4.0.0 3.24086E-06 None None None None N None 0 0 None 0 0 None 0 0 5.77594E-06 0 0
V/I 29828 Fn3-105 95 None 0.0916 None None N 0.325 0.14 0.29771876 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
V/G 30025 Fn3-106 93 rs1303810426 0.6478 -2.725 0.999 N 0.829 0.511 0.7911601 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/G 30025 Fn3-106 93 rs1303810426 0.6478 -2.725 0.999 N 0.829 0.511 0.7911601 gnomAD-4.0.0 6.57056E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
V/L 30025 Fn3-106 93 None 0.2559 None 0.994 N 0.65 0.227 0.569564 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
I/N 30120 Fn3-107 91 rs748786455 0.8965 -1.758 0.739 N 0.795 0.414 0.77679 gnomAD-2.1.1 2.41E-05 None None None None N None 0 0 None 0 3.35683E-04 None 0 None 0 0 0
I/N 30120 Fn3-107 91 rs748786455 0.8965 -1.758 0.739 N 0.795 0.414 0.77679 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 5.79151E-04 None 0 0 0 0 0
I/N 30120 Fn3-107 91 rs748786455 0.8965 -1.758 0.739 N 0.795 0.414 0.77679 gnomAD-4.0.0 2.35497E-05 None None None None N None 0 0 None 0 8.47987E-04 None 0 0 0 0 0
I/T 30120 Fn3-107 91 rs748786455 0.8191 -2.147 0.061 N 0.815 0.265 0.5720377 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
I/T 30120 Fn3-107 91 rs748786455 0.8191 -2.147 0.061 N 0.815 0.265 0.5720377 gnomAD-4.0.0 2.05271E-06 None None None None N None 0 0 None 3.82673E-05 0 None 0 0 1.79893E-06 0 0
I/N 30316 Fn3-108 93 rs140531141 0.6267 None 0.989 N 0.849 0.389 0.8396481 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/N 30316 Fn3-108 93 rs140531141 0.6267 None 0.989 N 0.849 0.389 0.8396481 gnomAD-4.0.0 1.24018E-06 None None None None N None 1.33483E-05 0 None 0 0 None 0 0 8.4825E-07 0 0
I/T 30316 Fn3-108 93 rs140531141 0.1354 -1.431 0.799 N 0.606 0.352 None 1000 genomes 3.99361E-04 None None None None N None 1.5E-03 0 None None 0 0 None None None 0 None
I/T 30316 Fn3-108 93 rs140531141 0.1354 -1.431 0.799 N 0.606 0.352 None gnomAD-2.1.1 2.01E-05 None None None None N None 1.29082E-04 0 None 0 1.67112E-04 None 0 None 0 0 0
I/T 30316 Fn3-108 93 rs140531141 0.1354 -1.431 0.799 N 0.606 0.352 None gnomAD-3.1.2 1.97E-05 None None None None N None 4.82E-05 0 0 0 1.92976E-04 None 0 0 0 0 0
I/T 30316 Fn3-108 93 rs140531141 0.1354 -1.431 0.799 N 0.606 0.352 None gnomAD-4.0.0 4.3403E-06 None None None None N None 2.66532E-05 0 None 0 8.9222E-05 None 0 0 8.48256E-07 0 0
I/V 30316 Fn3-108 93 None 0.0566 None 0.002 N 0.147 0.072 0.5501284 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 3.66327E-05
I/M 30515 Fn3-110 94 None 0.3147 None 0.062 N 0.329 0.215 0.20466535 gnomAD-4.0.0 1.59315E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43382E-05 0
I/T 30515 Fn3-110 94 rs2154150025 0.8057 None 0.682 N 0.716 0.402 0.610416 gnomAD-4.0.0 1.59299E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43365E-05 0
I/V 30515 Fn3-110 94 rs1699213843 0.1187 None 0.162 N 0.391 0.138 0.5265392 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
I/V 30515 Fn3-110 94 rs1699213843 0.1187 None 0.162 N 0.391 0.138 0.5265392 gnomAD-4.0.0 2.0299E-06 None None None None N None 0 6.1546E-05 None 0 0 None 0 0 0 4.6966E-05 0
V/A 30711 Fn3-111 93 None 0.1991 None 0.799 N 0.563 0.364 0.5103469 gnomAD-4.0.0 6.00161E-06 None None None None N None 0 0 None 0 0 None 0 0 6.56251E-06 0 0
V/L 30711 Fn3-111 93 rs747122 0.2039 0.365 0.451 N 0.408 0.208 0.2793702 gnomAD-2.1.1 8.1E-06 None None None None N None 0 0 None 0 1.11383E-04 None 0 None 0 0 0
V/L 30711 Fn3-111 93 rs747122 0.2039 0.365 0.451 N 0.408 0.208 0.2793702 gnomAD-4.0.0 4.79238E-06 None None None None N None 0 0 None 0 1.5124E-04 None 0 0 9.0008E-07 0 0
V/M 30711 Fn3-111 93 rs747122 0.1342 0.169 0.966 N 0.601 0.226 None 1000 genomes 1.5016E-01 None None None None N None 2.731E-01 1.787E-01 None None 2.48E-02 4.87E-02 None None None 1.973E-01 None
V/M 30711 Fn3-111 93 rs747122 0.1342 0.169 0.966 N 0.601 0.226 None gnomAD-2.1.1 9.35053E-02 None None None None N None 2.56101E-01 2.06017E-01 None 3.52987E-02 2.76212E-02 None 1.82074E-01 None 5.71589E-02 3.30381E-02 6.708E-02
V/M 30711 Fn3-111 93 rs747122 0.1342 0.169 0.966 N 0.601 0.226 None gnomAD-3.1.2 1.14218E-01 None None None None N None 2.55342E-01 1.74984E-01 4.93421E-02 3.60231E-02 2.44513E-02 None 5.88014E-02 8.86076E-02 3.14815E-02 1.777E-01 9.00383E-02
V/M 30711 Fn3-111 93 rs747122 0.1342 0.169 0.966 N 0.601 0.226 None gnomAD-4.0.0 5.89209E-02 None None None None N None 2.61695E-01 1.96786E-01 None 3.62696E-02 1.50488E-02 None 5.88529E-02 5.91345E-02 3.19641E-02 1.74096E-01 6.66037E-02
I/T 30813 Fn3-112 95 rs768897840 0.5797 -2.265 0.971 N 0.593 0.278 0.5242713 gnomAD-2.1.1 2.41E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 4.44E-05 0
I/T 30813 Fn3-112 95 rs768897840 0.5797 -2.265 0.971 N 0.593 0.278 0.5242713 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 30813 Fn3-112 95 rs768897840 0.5797 -2.265 0.971 N 0.593 0.278 0.5242713 gnomAD-4.0.0 2.91268E-05 None None None None N None 2.67087E-05 1.66761E-05 None 0 0 None 0 0 3.39032E-05 0 6.40512E-05
I/S 30914 Fn3-113 94 rs951807675 0.4399 -2.554 0.791 N 0.583 0.33 0.8011043 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
I/N 31108 Fn3-114 93 None 0.7172 None 0.177 N 0.735 0.327 0.7079194 gnomAD-4.0.0 6.84176E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99441E-07 0 0
I/S 31108 Fn3-114 93 None 0.4843 None 0.03 N 0.547 0.305 0.7119372 gnomAD-4.0.0 2.05253E-06 None None None None N None 2.98757E-05 0 None 0 0 None 0 0 1.79888E-06 0 0
I/T 31108 Fn3-114 93 rs373732722 0.1877 -2.249 0.001 N 0.281 0.256 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
I/T 31108 Fn3-114 93 rs373732722 0.1877 -2.249 0.001 N 0.281 0.256 None gnomAD-2.1.1 1.08672E-04 None None None None N None 0 1.15902E-04 None 0 5.57E-05 None 2.28758E-04 None 5.57258E-04 2.67E-05 0
I/T 31108 Fn3-114 93 rs373732722 0.1877 -2.249 0.001 N 0.281 0.256 None gnomAD-3.1.2 6.57E-05 None None None None N None 0 1.3101E-04 0 0 1.92678E-04 None 1.88182E-04 0 4.41E-05 4.1511E-04 0
I/T 31108 Fn3-114 93 rs373732722 0.1877 -2.249 0.001 N 0.281 0.256 None gnomAD-4.0.0 6.19626E-05 None None None None N None 3.99787E-05 1.49985E-04 None 0 2.22836E-05 None 3.59252E-04 0 2.71232E-05 2.74508E-04 1.12032E-04
I/V 31108 Fn3-114 93 rs727504787 0.0521 -1.009 None N 0.133 0.048 0.19193122 gnomAD-2.1.1 8.06E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
I/V 31108 Fn3-114 93 rs727504787 0.0521 -1.009 None N 0.133 0.048 0.19193122 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 31108 Fn3-114 93 rs727504787 0.0521 -1.009 None N 0.133 0.048 0.19193122 gnomAD-4.0.0 1.05345E-05 None None None None N None 1.33494E-05 3.33367E-05 None 0 0 None 0 0 9.32352E-06 0 4.80323E-05
V/I 31204 Fn3-115 92 rs750367979 0.0824 0.533 0.994 N 0.592 0.199 0.54844326 gnomAD-2.1.1 8.04E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
V/I 31204 Fn3-115 92 rs750367979 0.0824 0.533 0.994 N 0.592 0.199 0.54844326 gnomAD-4.0.0 3.18249E-06 None None None None N None 0 4.57373E-05 None 0 0 None 0 0 0 0 0
I/T 31400 Fn3-116 93 rs1261202731 0.4949 None 0.321 N 0.742 0.307 0.61724806 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 31400 Fn3-116 93 rs1261202731 0.4949 None 0.321 N 0.742 0.307 0.61724806 gnomAD-4.0.0 6.57082E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47003E-05 0 0
I/L 31501 Fn3-117 94 None 0.0651 None None N 0.237 0.087 0.15556084 gnomAD-4.0.0 6.84981E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00416E-07 0 0
I/T 31501 Fn3-117 94 rs758756316 0.1453 -2.273 0.006 N 0.491 0.158 0.59687436 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
I/T 31501 Fn3-117 94 rs758756316 0.1453 -2.273 0.006 N 0.491 0.158 0.59687436 gnomAD-4.0.0 2.55288E-05 None None None None N None 0 0 None 0 3.32926E-04 None 0 0 1.14726E-05 0 0
I/V 31501 Fn3-117 94 rs780578358 0.0474 -1.234 None N 0.177 0.076 0.11007815 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 4.67E-05 0 0
I/V 31501 Fn3-117 94 rs780578358 0.0474 -1.234 None N 0.177 0.076 0.11007815 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 9.41E-05 0 1.47E-05 0 0
I/V 31501 Fn3-117 94 rs780578358 0.0474 -1.234 None N 0.177 0.076 0.11007815 gnomAD-4.0.0 7.44366E-06 None None None None N None 0 0 None 0 0 None 1.40757E-04 0 2.54535E-06 0 0
V/F 31603 Fn3-118 98 rs1060500567 0.5114 None 0.449 N 0.752 0.236 0.5688924 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/F 31603 Fn3-118 98 rs1060500567 0.5114 None 0.449 N 0.752 0.236 0.5688924 gnomAD-4.0.0 1.24184E-06 None None None None N None 1.33579E-05 0 None 0 0 None 0 0 8.49475E-07 0 0
V/I 31603 Fn3-118 98 None 0.072 None 0.001 N 0.196 0.029 0.13967828 gnomAD-4.0.0 6.85721E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16055E-05 0
I/T 31799 Fn3-119 92 rs1696841409 0.1395 None 0.181 N 0.586 0.282 0.61309826 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
I/V 31799 Fn3-119 92 rs370916420 0.0496 -1.286 None N 0.144 0.06 None gnomAD-2.1.1 6.44E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 1.33585E-04 0
I/V 31799 Fn3-119 92 rs370916420 0.0496 -1.286 None N 0.144 0.06 None gnomAD-3.1.2 4.6E-05 None None None None N None 0 6.54E-05 0 0 0 None 0 3.16456E-03 7.35E-05 0 0
I/V 31799 Fn3-119 92 rs370916420 0.0496 -1.286 None N 0.144 0.06 None gnomAD-4.0.0 6.01123E-05 None None None None N None 0 1.66617E-05 None 0 0 None 0 1.65071E-04 7.46002E-05 1.09813E-05 9.60553E-05
I/N 32003 Fn3-121 95 rs745962752 0.2905 None 0.974 N 0.698 0.365 0.8411385 gnomAD-4.0.0 2.1219E-05 None None None None N None 0 0 None 0 0 None 0 0 2.69969E-05 0 1.65706E-05
I/T 32003 Fn3-121 95 rs745962752 0.0771 -2.294 0.067 N 0.243 0.234 0.5900218 gnomAD-2.1.1 1.21E-05 None None None None N None 1.93748E-04 0 None 0 0 None 0 None 0 0 0
I/T 32003 Fn3-121 95 rs745962752 0.0771 -2.294 0.067 N 0.243 0.234 0.5900218 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
I/T 32003 Fn3-121 95 rs745962752 0.0771 -2.294 0.067 N 0.243 0.234 0.5900218 gnomAD-4.0.0 2.66564E-05 None None None None N None 6.6761E-05 0 None 0 7.3536E-04 None 0 0 3.39197E-06 0 1.60159E-05
V/I 32197 Fn3-122 93 None 0.0778 None 0.008 N 0.261 0.068 0.29314703 gnomAD-4.0.0 6.84189E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99452E-07 0 0
V/L 32197 Fn3-122 93 rs1296702975 0.2601 -0.258 0.343 N 0.589 0.248 0.2793702 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 5.58E-05 None 3.27E-05 None 0 0 0
V/L 32197 Fn3-122 93 rs1296702975 0.2601 -0.258 0.343 N 0.589 0.248 0.2793702 gnomAD-4.0.0 4.10514E-06 None None None None N None 0 0 None 0 2.51965E-05 None 0 0 0 4.63725E-05 1.65656E-05
V/M 32295 Fn3-123 94 rs199532781 0.27 -0.386 1.0 N 0.789 0.277 None gnomAD-2.1.1 7.67E-05 None None None None N None 1.66486E-04 0 None 0 2.56358E-04 None 2.05226E-04 None 0 4.79E-05 0
V/M 32295 Fn3-123 94 rs199532781 0.27 -0.386 1.0 N 0.789 0.277 None gnomAD-3.1.2 7.96E-05 None None None None N None 1.71518E-04 0 0 0 1.94326E-04 None 0 0 4.42E-05 2.09118E-04 0
V/M 32295 Fn3-123 94 rs199532781 0.27 -0.386 1.0 N 0.789 0.277 None gnomAD-4.0.0 7.0152E-05 None None None None N None 1.21379E-04 3.3627E-05 None 0 1.34747E-04 None 1.60205E-05 1.66556E-04 5.81821E-05 2.56662E-04 3.23729E-05
I/K 32491 Fn3-124 93 None 0.4411 None 0.895 N 0.687 0.434 0.7288061 gnomAD-4.0.0 6.8563E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00612E-07 0 0
I/L 32491 Fn3-124 93 rs1178554764 0.1427 None 0.098 N 0.294 0.045 0.28178066 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/L 32491 Fn3-124 93 rs1178554764 0.1427 None 0.098 N 0.294 0.045 0.28178066 gnomAD-4.0.0 6.57272E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47029E-05 0 0
I/T 32491 Fn3-124 93 rs781572378 0.0957 -0.351 0.546 N 0.491 0.303 0.46298257 gnomAD-2.1.1 3.27E-05 None None None None I None 4.23E-05 1.43308E-04 None 0 0 None 6.69E-05 None 0 7.97E-06 0
I/T 32491 Fn3-124 93 rs781572378 0.0957 -0.351 0.546 N 0.491 0.303 0.46298257 gnomAD-3.1.2 4.6E-05 None None None None I None 9.65E-05 6.55E-05 0 0 0 None 0 0 2.94E-05 0 0
I/T 32491 Fn3-124 93 rs781572378 0.0957 -0.351 0.546 N 0.491 0.303 0.46298257 gnomAD-4.0.0 2.29723E-05 None None None None I None 5.34402E-05 1.17296E-04 None 0 0 None 0 0 1.86699E-05 2.21004E-05 3.20832E-05
I/V 32592 Fn3-125 94 None 0.0554 None None N 0.161 0.092 0.26821154 gnomAD-4.0.0 1.46314E-06 None None None None N None 3.17319E-05 0 None 0 0 None 0 0 0 1.35146E-05 0
I/L 33091 Fn3-129 94 rs879450752 0.1352 None 0.012 D 0.399 0.176 0.1899582 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/L 33091 Fn3-129 94 rs879450752 0.1352 None 0.012 D 0.399 0.176 0.1899582 gnomAD-4.0.0 4.96205E-06 None None None None N None 0 0 None 0 0 None 0 0 6.78507E-06 0 0
I/M 33091 Fn3-129 94 rs746305727 0.1261 None 0.314 N 0.732 0.136 0.5579534 gnomAD-4.0.0 1.23297E-05 None None None None N None 0 0 None 0 0 None 0 0 1.62022E-05 0 0
I/R 33091 Fn3-129 94 None 0.6513 None 0.481 N 0.868 0.366 0.8052662 gnomAD-4.0.0 1.59537E-06 None None None None N None 0 0 None 0 2.77423E-05 None 0 0 0 0 0
I/V 33091 Fn3-129 94 rs879450752 0.0569 None None N 0.173 0.175 0.15698698 gnomAD-4.0.0 6.84925E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00066E-07 0 0
V/M 33384 Fn3-130 95 None 0.2824 None 0.999 N 0.731 0.13 0.46017456 gnomAD-4.0.0 2.05431E-06 None None None None I None 0 0 None 0 0 None 0 0 2.70003E-06 0 0
I/T 33485 Fn3-131 94 rs369247146 0.2393 -2.755 0.03 N 0.653 0.107 0.36414173 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/T 33485 Fn3-131 94 rs369247146 0.2393 -2.755 0.03 N 0.653 0.107 0.36414173 gnomAD-4.0.0 1.59164E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43312E-05 0
I/V 33485 Fn3-131 94 rs2154137339 0.0598 None None N 0.135 0.091 0.09208627 gnomAD-4.0.0 1.59157E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85848E-06 0 0
T/I 33780 Fn3-132 92 rs2154136558 0.1054 None None N 0.355 0.195 0.23990108 gnomAD-4.0.0 1.36835E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31863E-05 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.