Structural position:

  • Domain Type: Fn3
  • Aligned Position: 129
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand G

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
E/D 15751 Fn3-1 95 rs764193921 0.3437 -0.883 0.893 N 0.417 0.082 0.273070737957 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
E/D 15751 Fn3-1 95 rs764193921 0.3437 -0.883 0.893 N 0.417 0.082 0.273070737957 gnomAD-4.0.0 2.05408E-06 None None None None N None 2.99491E-05 0 None 0 0 None 0 0 1.79984E-06 0 0
E/K 15751 Fn3-1 95 rs2057702723 0.2792 None 0.91 N 0.452 0.216 0.222439326576 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 15751 Fn3-1 95 rs2057702723 0.2792 None 0.91 N 0.452 0.216 0.222439326576 gnomAD-4.0.0 6.58241E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4728E-05 0 0
K/T 15852 Fn3-2 95 None 0.1503 None 0.999 N 0.762 0.413 0.228597637076 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 15953 Fn3-3 95 None 0.1048 None 0.376 N 0.494 0.095 0.260735089382 gnomAD-4.0.0 2.40098E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62537E-06 0 0
Q/K 16248 Fn3-5 94 rs890836589 0.1382 0.182 0.89 N 0.451 0.184 0.159798565429 gnomAD-2.1.1 5.32E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.27E-05 0
Q/K 16248 Fn3-5 94 rs890836589 0.1382 0.182 0.89 N 0.451 0.184 0.159798565429 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/K 16248 Fn3-5 94 rs890836589 0.1382 0.182 0.89 N 0.451 0.184 0.159798565429 gnomAD-4.0.0 1.33488E-05 None None None None N None 0 0 None 0 0 None 0 0 1.72726E-05 0 1.63951E-05
Q/R 16248 Fn3-5 94 rs2057018597 0.1671 None 0.89 N 0.583 0.097 0.163833314356 gnomAD-4.0.0 1.70085E-06 None None None None N None 0 0 None 0 0 None 0 0 3.04951E-06 0 0
S/P 16845 Fn3-10 95 rs761406700 0.1506 -0.311 0.052 N 0.496 0.105 0.0297737177859 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.3E-05 None 0 0 0
S/P 16845 Fn3-10 95 rs761406700 0.1506 -0.311 0.052 N 0.496 0.105 0.0297737177859 gnomAD-4.0.0 1.59496E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4386E-05 0
V/L 16947 Fn3-11 96 rs765033370 0.2074 -0.496 0.278 N 0.442 0.125 0.283761946502 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
V/L 16947 Fn3-11 96 rs765033370 0.2074 -0.496 0.278 N 0.442 0.125 0.283761946502 gnomAD-4.0.0 4.78022E-06 None None None None N None 0 0 None 0 0 None 0 0 8.58512E-06 0 0
I/F 17140 Fn3-12 94 None 0.3209 None 0.808 N 0.499 0.143 0.48300943003 gnomAD-4.0.0 1.59336E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86172E-06 0 0
I/V 17140 Fn3-12 94 rs1457519537 0.1114 -0.639 0.004 N 0.204 0.047 0.3571064206 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/V 17140 Fn3-12 94 rs1457519537 0.1114 -0.639 0.004 N 0.204 0.047 0.3571064206 gnomAD-4.0.0 1.59336E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43328E-05 0
K/R 17241 Fn3-13 95 None 0.0983 None 0.997 N 0.758 0.236 0.335910606209 gnomAD-4.0.0 6.92065E-07 None None None None N None 0 0 None 0 0 None 0 0 9.07652E-07 0 0
T/A 17662 Fn3-16 94 None 0.1022 None 0.688 N 0.36 0.157 0.238705975628 gnomAD-4.0.0 1.59297E-06 None None None None N None 0 0 None 0 2.78443E-05 None 0 0 0 0 0
I/V 17956 Fn3-18 95 None 0.2439 None 0.188 N 0.215 0.119 0.415055319159 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 18265 Fn3-20 100 rs2054138018 0.1486 None 0.002 N 0.173 0.066 0.368743488249 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
V/A 18265 Fn3-20 100 rs2054138018 0.1486 None 0.002 N 0.173 0.066 0.368743488249 gnomAD-4.0.0 3.91767E-06 None None None None N None 1.70126E-05 0 None 0 0 None 0 0 4.91328E-06 0 0
V/I 18265 Fn3-20 100 rs397517621 0.0686 None None N 0.087 0.048 0.104622674875 gnomAD-4.0.0 1.61921E-06 None None None None N None 0 0 None 0 0 None 0 0 2.92423E-06 0 0
P/L 18368 Fn3-21 97 rs750193854 0.079 -0.245 None N 0.43 0.157 0.462635795511 gnomAD-2.1.1 8.08E-06 None None None None N None 0 5.82E-05 None 0 0 None 0 None 0 0 0
P/L 18368 Fn3-21 97 rs750193854 0.079 -0.245 None N 0.43 0.157 0.462635795511 gnomAD-4.0.0 3.18738E-06 None None None None N None 0 4.58022E-05 None 0 0 None 0 0 0 0 0
P/S 18368 Fn3-21 97 rs1220806171 0.1323 -0.948 0.03 N 0.553 0.211 0.17948927462 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14863E-04 0 None 0 0 None 0 None 0 0 0
T/A 18572 Fn3-22 94 rs537445357 0.0982 -0.942 0.435 N 0.428 0.129 None gnomAD-2.1.1 1.66E-05 None None None None N None 1.69693E-04 0 None 0 0 None 0 None 0 0 0
T/A 18572 Fn3-22 94 rs537445357 0.0982 -0.942 0.435 N 0.428 0.129 None gnomAD-3.1.2 4.6E-05 None None None None N None 1.6887E-04 0 0 0 0 None 0 0 0 0 0
T/A 18572 Fn3-22 94 rs537445357 0.0982 -0.942 0.435 N 0.428 0.129 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
T/A 18572 Fn3-22 94 rs537445357 0.0982 -0.942 0.435 N 0.428 0.129 None gnomAD-4.0.0 1.02665E-05 None None None None N None 2.06521E-04 0 None 0 0 None 0 0 8.65212E-07 0 0
T/I 18572 Fn3-22 94 None 0.1354 None 0.93 N 0.563 0.104 0.361958692863 gnomAD-4.0.0 4.26862E-06 None None None None N None 0 0 None 0 0 None 0 0 4.59772E-06 0 1.72939E-05
T/I 18678 Fn3-23 100 None 0.0577 None None N None 0.098 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
T/N 18678 Fn3-23 100 rs2053232530 0.1102 None None N None 0.265 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/D 19082 Fn3-26 95 None 0.4226 None 0.991 N 0.589 0.128 0.292062946507 gnomAD-4.0.0 1.59246E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85986E-06 0 0
V/I 19277 Fn3-27 95 rs1398372843 0.0713 -0.044 None N 0.114 0.075 0.422160833541 gnomAD-2.1.1 5.91E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.47E-05 0
V/I 19277 Fn3-27 95 rs1398372843 0.0713 -0.044 None N 0.114 0.075 0.422160833541 gnomAD-4.0.0 7.11096E-07 None None None None N None 0 0 None 0 0 None 0 0 9.23996E-07 0 0
V/L 19277 Fn3-27 95 None 0.1093 None None N 0.103 0.072 0.347879110917 gnomAD-4.0.0 7.11096E-07 None None None None N None 0 0 None 0 0 None 0 0 9.23996E-07 0 0
T/I 19378 Fn3-28 95 rs371456511 0.1445 -0.225 0.999 N 0.687 0.321 None gnomAD-2.1.1 8.56E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.27E-06 1.76616E-04
T/I 19378 Fn3-28 95 rs371456511 0.1445 -0.225 0.999 N 0.687 0.321 None gnomAD-4.0.0 6.56955E-06 None None None None N None 0 0 None 0 0 None 0 0 1.17284E-05 0 0
E/D 20068 Fn3-33 92 rs774629592 0.2617 -0.297 0.971 N 0.451 0.164 0.267299060538 gnomAD-2.1.1 4.04E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
E/D 20068 Fn3-33 92 rs774629592 0.2617 -0.297 0.971 N 0.451 0.164 0.267299060538 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/D 20068 Fn3-33 92 rs774629592 0.2617 -0.297 0.971 N 0.451 0.164 0.267299060538 gnomAD-4.0.0 6.57471E-06 None None None None N None 2.41278E-05 0 None 0 0 None 0 0 0 0 0
E/K 20068 Fn3-33 92 rs759291854 0.1345 0.469 0.971 N 0.427 0.276 0.28722502521 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.31E-05 None 0 0 0
E/K 20068 Fn3-33 92 rs759291854 0.1345 0.469 0.971 N 0.427 0.276 0.28722502521 gnomAD-4.0.0 2.05446E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79957E-06 1.16705E-05 0
E/Q 20068 Fn3-33 92 rs759291854 0.1124 0.059 0.971 N 0.511 0.243 0.329282125956 gnomAD-2.1.1 4.04E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
E/Q 20068 Fn3-33 92 rs759291854 0.1124 0.059 0.971 N 0.511 0.243 0.329282125956 gnomAD-3.1.2 2.63E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
E/Q 20068 Fn3-33 92 rs759291854 0.1124 0.059 0.971 N 0.511 0.243 0.329282125956 gnomAD-4.0.0 2.6303E-05 None None None None N None 9.65298E-05 0 None 0 0 None 0 0 0 0 0
K/T 20364 Fn3-35 94 None 0.241 None 0.999 N 0.776 0.282 0.256283259241 gnomAD-4.0.0 1.59266E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86105E-06 0 0
I/S 20466 Fn3-36 96 None 0.2921 None 0.22 N 0.471 0.178 0.574091456918 gnomAD-4.0.0 7.04896E-06 None None None None N None 0 0 None 0 0 None 0 0 9.16209E-06 0 0
I/T 20466 Fn3-36 96 rs372745397 0.1171 -0.898 0.008 N 0.337 0.103 None gnomAD-2.1.1 9.43E-06 None None None None N None 1.32926E-04 0 None 0 0 None 0 None 0 0 0
I/T 20466 Fn3-36 96 rs372745397 0.1171 -0.898 0.008 N 0.337 0.103 None gnomAD-4.0.0 2.11469E-06 None None None None N None 0 2.4914E-05 None 0 0 None 0 0 0 0 3.41869E-05
V/L 21057 Fn3-40 95 rs2049556477 0.1424 None 0.278 N 0.43 0.101 0.300784259202 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/L 21057 Fn3-40 95 rs2049556477 0.1424 None 0.278 N 0.43 0.101 0.300784259202 gnomAD-4.0.0 1.30692E-06 None None None None N None 0 0 None 0 0 None 0 0 1.75032E-06 0 0
V/M 21057 Fn3-40 95 rs2049556477 0.1177 None 0.868 N 0.406 0.105 0.380394304726 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/M 21057 Fn3-40 95 rs2049556477 0.1177 None 0.868 N 0.406 0.105 0.380394304726 gnomAD-4.0.0 2.61384E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62548E-06 1.3438E-05 0
L/V 21359 Fn3-42 94 None 0.0953 None 0.802 N 0.724 0.083 0.293147016451 gnomAD-4.0.0 1.59242E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86107E-06 0 0
E/K 21460 Fn3-43 95 None 0.3178 None 0.997 N 0.776 0.387 0.466313656995 gnomAD-4.0.0 1.59286E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86167E-06 0 0
T/I 21753 Fn3-45 95 rs748999109 0.2244 0.021 0.999 N 0.797 0.377 0.541875726618 gnomAD-2.1.1 9.01E-06 None None None None N None 0 0 None 0 1.167E-04 None 0 None 0 0 0
T/I 21753 Fn3-45 95 rs748999109 0.2244 0.021 0.999 N 0.797 0.377 0.541875726618 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.9425E-04 None 0 0 0 0 0
T/I 21753 Fn3-45 95 rs748999109 0.2244 0.021 0.999 N 0.797 0.377 0.541875726618 gnomAD-4.0.0 4.07279E-06 None None None None N None 0 0 None 0 7.3928E-05 None 0 0 0 0 0
Y/H 22251 Fn3-49 96 rs1298637846 0.102 -0.383 0.05 N 0.369 0.05 0.166414681773 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
Y/N 22251 Fn3-49 96 rs1298637846 0.0881 -0.066 0.003 N 0.353 0.057 0.309530620856 gnomAD-2.1.1 4.13E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.16E-06 0
Y/N 22251 Fn3-49 96 rs1298637846 0.0881 -0.066 0.003 N 0.353 0.057 0.309530620856 gnomAD-4.0.0 1.62264E-06 None None None None N None 0 0 None 0 0 None 0 0 2.92495E-06 0 0
K/R 22447 Fn3-50 94 rs766331736 0.0962 0.343 0.029 N 0.197 0.093 0.250039746154 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
K/R 22447 Fn3-50 94 rs766331736 0.0962 0.343 0.029 N 0.197 0.093 0.250039746154 gnomAD-4.0.0 4.77812E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86049E-06 0 6.05437E-05
V/L 22540 Fn3-51 90 None 0.1138 None None N 0.186 0.063 0.277730125212 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/L 22837 Fn3-53 95 None 0.2092 None 0.944 N 0.459 0.115 0.380223377699 gnomAD-4.0.0 4.77934E-06 None None None None I None 0 0 None 0 0 None 0 0 8.58305E-06 0 0
K/N 23528 Fn3-58 94 None 0.772 None 0.163 N 0.628 0.1 0.117506650769 gnomAD-4.0.0 1.59151E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85907E-06 0 0
I/T 23623 Fn3-59 92 rs1709646432 0.0821 None None N 0.349 0.162 0.364342057095 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 23623 Fn3-59 92 rs1218196881 0.0602 -0.536 None N 0.085 0.085 0.237489013734 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
I/V 23623 Fn3-59 92 rs1218196881 0.0602 -0.536 None N 0.085 0.085 0.237489013734 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 23623 Fn3-59 92 rs1218196881 0.0602 -0.536 None N 0.085 0.085 0.237489013734 gnomAD-4.0.0 6.57419E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4708E-05 0 0
L/S 23920 Fn3-61 95 None 0.2465 None None N 0.441 0.153 0.474168873855 gnomAD-4.0.0 1.59159E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85902E-06 0 0
K/E 24316 Fn3-64 95 rs745520420 0.3304 0.215 0.997 N 0.815 0.299 0.311691414656 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 3.34E-05 None 0 0 0
K/E 24316 Fn3-64 95 rs745520420 0.3304 0.215 0.997 N 0.815 0.299 0.311691414656 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06868E-04 0
K/E 24316 Fn3-64 95 rs745520420 0.3304 0.215 0.997 N 0.815 0.299 0.311691414656 gnomAD-4.0.0 2.4838E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.31236E-05 1.60503E-05
K/T 24612 Fn3-66 94 None 0.6989 None 0.198 N 0.424 0.124 0.184867976434 gnomAD-4.0.0 1.59559E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86906E-06 0 0
I/F 24708 Fn3-67 93 rs1364240717 0.2111 -0.76 0.54 N 0.409 0.082 0.450733807028 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
I/F 24708 Fn3-67 93 rs1364240717 0.2111 -0.76 0.54 N 0.409 0.082 0.450733807028 gnomAD-4.0.0 1.59249E-06 None None None None N None 0 0 None 0 0 None 0 2.41779E-04 0 0 0
I/M 24708 Fn3-67 93 rs758928659 0.1015 -0.45 0.473 N 0.483 0.076 0.31411915649 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
I/M 24708 Fn3-67 93 rs758928659 0.1015 -0.45 0.473 N 0.483 0.076 0.31411915649 gnomAD-4.0.0 6.84455E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99622E-07 0 0
T/I 25101 Fn3-70 96 rs1286105524 0.2225 0.09 0.071 N 0.315 0.278 0.300449992093 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/I 25101 Fn3-70 96 rs1286105524 0.2225 0.09 0.071 N 0.315 0.278 0.300449992093 gnomAD-4.0.0 1.59177E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8592E-06 0 0
K/M 25398 Fn3-72 95 None 0.2916 None 0.997 N 0.685 0.293 0.284539287134 gnomAD-4.0.0 1.5933E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86175E-06 0 0
K/R 25398 Fn3-72 95 rs1467808986 0.0823 0.198 0.027 N 0.359 0.066 0.218845423259 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.61E-05 None 0 None 0 0 0
K/R 25398 Fn3-72 95 rs1467808986 0.0823 0.198 0.027 N 0.359 0.066 0.218845423259 gnomAD-4.0.0 1.5933E-06 None None None None N None 0 0 None 0 2.78025E-05 None 0 0 0 0 0
I/M 25500 Fn3-73 96 rs1707397536 0.0654 None 0.001 N 0.19 0.043 0.236278675362 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/M 25500 Fn3-73 96 rs1707397536 0.0654 None 0.001 N 0.19 0.043 0.236278675362 gnomAD-4.0.0 6.57505E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4708E-05 0 0
I/T 25500 Fn3-73 96 rs1485761373 0.0703 -1.408 0.058 N 0.627 0.115 0.385417323374 gnomAD-2.1.1 4.09E-06 None None None None N None 0 0 None 0 0 None 0 None 4.68E-05 0 0
I/T 25500 Fn3-73 96 rs1485761373 0.0703 -1.408 0.058 N 0.627 0.115 0.385417323374 gnomAD-4.0.0 6.38246E-06 None None None None N None 0 0 None 0 5.58316E-05 None 1.88651E-05 0 2.86461E-06 0 0
K/N 25694 Fn3-74 94 rs757757476 0.8402 0.207 0.999 N 0.806 0.176 0.149567049428 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/N 25694 Fn3-74 94 rs757757476 0.8402 0.207 0.999 N 0.806 0.176 0.149567049428 gnomAD-4.0.0 1.59237E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43402E-05 0
V/A 25790 Fn3-75 93 None 0.2409 None 0.012 N 0.402 0.116 0.466907325337 gnomAD-4.0.0 1.5936E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86236E-06 0 0
V/A 26084 Fn3-77 95 rs1252241115 0.1728 None 0.002 N 0.23 0.143 0.392547445146 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 26084 Fn3-77 95 rs1252241115 0.1728 None 0.002 N 0.23 0.143 0.392547445146 gnomAD-4.0.0 6.57497E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47089E-05 0 0
V/I 26084 Fn3-77 95 None 0.0736 None 0.002 N 0.171 0.084 0.320256813643 gnomAD-4.0.0 3.18356E-06 None None None None N None 0 0 None 0 5.54631E-05 None 0 0 0 0 0
L/R 26379 Fn3-79 94 None 0.1865 None 0.8 N 0.635 0.413 0.772253545797 gnomAD-4.0.0 1.36854E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99552E-07 0 1.65717E-05
L/V 26379 Fn3-79 94 rs1706131161 0.0681 None 0.001 N 0.196 0.039 0.208816687407 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/V 26379 Fn3-79 94 rs1706131161 0.0681 None 0.001 N 0.196 0.039 0.208816687407 gnomAD-4.0.0 6.57713E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47054E-05 0 0
K/N 26480 Fn3-80 95 None 0.8371 None 0.997 N 0.635 0.249 0.144782658237 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
K/Q 26582 Fn3-81 96 rs775918922 0.1627 -0.427 0.931 N 0.641 0.307 0.345859378078 gnomAD-2.1.1 1.61E-05 None None None None N None 0 1.15908E-04 None 0 0 None 0 None 0 0 0
K/Q 26582 Fn3-81 96 rs775918922 0.1627 -0.427 0.931 N 0.641 0.307 0.345859378078 gnomAD-4.0.0 6.36736E-06 None None None None N None 0 9.14578E-05 None 0 0 None 0 0 0 0 0
K/T 26582 Fn3-81 96 None 0.2138 None 0.964 N 0.612 0.382 0.45783149361 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
I/T 26872 Fn3-83 93 rs1167097128 0.1197 -0.997 0.027 N 0.224 0.168 0.483670899158 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
I/T 26872 Fn3-83 93 rs1167097128 0.1197 -0.997 0.027 N 0.224 0.168 0.483670899158 gnomAD-4.0.0 6.36752E-06 None None None None N None 0 0 None 0 0 None 0 0 1.14379E-05 0 0
V/I 27166 Fn3-85 95 None 0.0783 None 0.546 N 0.505 0.121 0.27132560031 gnomAD-4.0.0 1.36863E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99522E-07 1.15942E-05 0
T/I 27265 Fn3-86 96 rs371129005 0.1999 0.215 0.125 N 0.37 0.234 None gnomAD-2.1.1 3.22E-05 None None None None N None 3.30715E-04 0 None 0 0 None 0 None 0 7.83E-06 0
T/I 27265 Fn3-86 96 rs371129005 0.1999 0.215 0.125 N 0.37 0.234 None gnomAD-3.1.2 1.05195E-04 None None None None N None 3.86156E-04 0 0 0 0 None 0 0 0 0 0
T/I 27265 Fn3-86 96 rs371129005 0.1999 0.215 0.125 N 0.37 0.234 None gnomAD-4.0.0 1.54936E-05 None None None None N None 3.07076E-04 0 None 0 2.23075E-05 None 0 0 8.47637E-07 0 0
T/K 27462 Fn3-87 94 None 0.0899 -0.4 0.033 N 0.444 0.234 None gnomAD-2.1.1 5.59899E-03 None None None None N None 4.99752E-02 2.74523E-03 None 1.69475E-02 0 None 3.27E-05 None 0 4.06803E-04 4.63483E-03
T/K 27462 Fn3-87 94 None 0.0899 -0.4 0.033 N 0.444 0.234 None gnomAD-3.1.2 1.48864E-02 None None None None N None 4.97994E-02 5.64156E-03 0 1.49942E-02 0 None 0 6.32911E-03 3.97047E-04 0 1.67464E-02
T/K 27462 Fn3-87 94 None 0.0899 -0.4 0.033 N 0.444 0.234 None 1000 genomes 1.55751E-02 None None None None N None 5.6E-02 5.8E-03 None None 0 0 None None None 0 None
T/K 27462 Fn3-87 94 None 0.0899 -0.4 0.033 N 0.444 0.234 None gnomAD-4.0.0 3.24422E-03 None None None None N None 5.10283E-02 3.9013E-03 None 1.683E-02 0 None 1.56255E-05 5.61241E-03 2.49206E-04 6.58776E-05 5.4741E-03
T/M 27462 Fn3-87 94 rs55933739 0.0533 0.174 0.082 N 0.541 0.184 0.204665344411 gnomAD-2.1.1 6.07E-05 None None None None N None 4.13E-05 0 None 0 0 None 2.61472E-04 None 0 6.26E-05 0
T/M 27462 Fn3-87 94 rs55933739 0.0533 0.174 0.082 N 0.541 0.184 0.204665344411 gnomAD-3.1.2 7.24E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 8.82E-05 6.21375E-04 0
T/M 27462 Fn3-87 94 rs55933739 0.0533 0.174 0.082 N 0.541 0.184 0.204665344411 gnomAD-4.0.0 8.86194E-05 None None None None N None 6.66827E-05 0 None 3.37952E-05 0 None 0 1.65071E-04 8.73068E-05 3.18408E-04 6.40246E-05
T/R 27462 Fn3-87 94 rs55933739 0.0787 0.018 0.076 N 0.547 0.172 0.1749357433 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
R/C 27563 Fn3-88 95 rs72648214 0.1473 -0.406 0.991 N 0.39 0.371 0.534239989213 gnomAD-2.1.1 3.22E-05 None None None None N None 0 0 None 0 1.11995E-04 None 0 None 0 5.34E-05 0
R/C 27563 Fn3-88 95 rs72648214 0.1473 -0.406 0.991 N 0.39 0.371 0.534239989213 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/C 27563 Fn3-88 95 rs72648214 0.1473 -0.406 0.991 N 0.39 0.371 0.534239989213 gnomAD-4.0.0 1.23962E-05 None None None None N None 1.33622E-05 0 None 0 8.93256E-05 None 0 1.64474E-04 1.10195E-05 1.09791E-05 0
R/H 27563 Fn3-88 95 rs118079537 0.0897 -1.001 0.01 N 0.234 0.1 None gnomAD-2.1.1 2.50275E-04 None None None None N None 0 1.13231E-04 None 0 3.14077E-03 None 6.54E-05 None 0 2.35E-05 0
R/H 27563 Fn3-88 95 rs118079537 0.0897 -1.001 0.01 N 0.234 0.1 None gnomAD-3.1.2 1.31574E-04 None None None None N None 0 0 0 0 3.48702E-03 None 0 0 2.94E-05 0 0
R/H 27563 Fn3-88 95 rs118079537 0.0897 -1.001 0.01 N 0.234 0.1 None 1000 genomes 5.99042E-04 None None None None N None 0 0 None None 3E-03 0 None None None 0 None
R/H 27563 Fn3-88 95 rs118079537 0.0897 -1.001 0.01 N 0.234 0.1 None gnomAD-4.0.0 6.75517E-05 None None None None N None 0 5.00367E-05 None 0 1.69726E-03 None 0 0 2.2039E-05 2.19587E-05 3.20123E-05
R/S 27563 Fn3-88 95 rs72648214 0.3759 None 0.208 N 0.406 0.241 0.253205268125 gnomAD-4.0.0 6.84261E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99489E-07 0 0
V/F 27665 Fn3-89 96 None 0.1133 None None N 0.354 0.084 0.300449992093 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/G 27665 Fn3-89 96 rs1704304364 0.2071 None 0.013 N 0.461 0.189 0.436132833422 gnomAD-4.0.0 6.84237E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
K/E 27859 Fn3-90 94 rs761633407 0.6511 0.841 0.981 N 0.668 0.259 0.31501682445 gnomAD-2.1.1 7.32E-05 None None None None N None 0 0 None 0 9.53556E-04 None 3.37E-05 None 0 0 0
K/E 27859 Fn3-90 94 rs761633407 0.6511 0.841 0.981 N 0.668 0.259 0.31501682445 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 9.64878E-04 None 0 0 0 0 0
K/E 27859 Fn3-90 94 rs761633407 0.6511 0.841 0.981 N 0.668 0.259 0.31501682445 gnomAD-4.0.0 2.483E-05 None None None None N None 0 0 None 0 6.47264E-04 None 0 0 0 7.75297E-05 6.41293E-05
K/N 27859 Fn3-90 94 None 0.8371 None 0.999 N 0.658 0.23 0.285698343383 gnomAD-4.0.0 1.59889E-06 None None None None N None 0 0 None 0 2.77747E-05 None 0 0 0 0 0
I/N 27955 Fn3-91 93 None 0.3661 None 0.877 N 0.533 0.309 0.732347765206 gnomAD-4.0.0 1.59219E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43398E-05 0
P/L 28248 Fn3-93 95 None 0.0943 None 0.049 N 0.381 0.139 0.277730125212 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/T 28248 Fn3-93 95 None 0.1073 None 0.049 N 0.393 0.046 0.139678290688 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
I/R 28347 Fn3-94 96 rs397517731 0.2042 -0.352 0.016 N 0.605 0.166 0.531727546574 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/R 28347 Fn3-94 96 rs397517731 0.2042 -0.352 0.016 N 0.605 0.166 0.531727546574 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.31062E-04 0 0 0 None 0 0 0 0 0
I/R 28347 Fn3-94 96 rs397517731 0.2042 -0.352 0.016 N 0.605 0.166 0.531727546574 gnomAD-4.0.0 1.85899E-06 None None None None N None 0 5.00167E-05 None 0 0 None 0 0 0 0 0
I/T 28347 Fn3-94 96 rs397517731 0.0501 -1.42 None N 0.104 0.148 0.396494342077 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 1.65782E-04
I/T 28347 Fn3-94 96 rs397517731 0.0501 -1.42 None N 0.104 0.148 0.396494342077 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 28347 Fn3-94 96 rs397517731 0.0501 -1.42 None N 0.104 0.148 0.396494342077 gnomAD-4.0.0 2.04489E-05 None None None None N None 0 0 None 0 0 None 0 0 2.79701E-05 0 0
I/V 28347 Fn3-94 96 rs1553563774 0.0657 None 0.001 N 0.148 0.148 0.341226946553 gnomAD-4.0.0 2.05256E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69834E-06 0 0
K/E 28543 Fn3-95 94 None 0.2183 None 0.007 N 0.336 0.161 0.280987212366 gnomAD-4.0.0 1.36907E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99758E-07 0 1.65755E-05
R/G 28644 Fn3-96 95 None 0.2679 None 0.361 N 0.549 0.194 0.290962096972 gnomAD-4.0.0 9.60257E-06 None None None None N None 0 0 None 0 0 None 0 0 1.05E-05 0 0
R/S 28644 Fn3-96 95 rs1322931412 0.4098 -0.913 0.22 N 0.484 0.147 0.101711395817 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
R/S 28644 Fn3-96 95 rs1322931412 0.4098 -0.913 0.22 N 0.484 0.147 0.101711395817 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/S 28644 Fn3-96 95 rs1322931412 0.4098 -0.913 0.22 N 0.484 0.147 0.101711395817 gnomAD-4.0.0 6.40669E-06 None None None None N None 0 0 None 0 0 None 0 0 1.19661E-05 0 0
I/M 28744 Fn3-97 94 None 0.0759 None 0.177 N 0.499 0.017 0.220303561663 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/N 28938 Fn3-98 94 rs770082146 0.8295 0.043 0.999 N 0.72 0.25 0.197625483188 gnomAD-2.1.1 4.27E-06 None None None None N None 0 3.18E-05 None 0 0 None 0 None 0 0 0
K/N 28938 Fn3-98 94 rs770082146 0.8295 0.043 0.999 N 0.72 0.25 0.197625483188 gnomAD-4.0.0 3.31181E-06 None None None None N None 0 4.98753E-05 None 0 0 None 0 0 0 0 0
K/R 28938 Fn3-98 94 None 0.0944 None 0.185 N 0.419 0.079 0.197625483188 gnomAD-4.0.0 1.2004E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31258E-06 0 0
L/M 29331 Fn3-101 95 None 0.1915 None 0.999 N 0.682 0.157 0.429091045357 gnomAD-4.0.0 1.3684E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79884E-06 0 0
T/I 29430 Fn3-102 96 rs1224484023 0.1466 0.082 0.999 N 0.769 0.402 0.409398589964 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
T/P 29430 Fn3-102 96 None 0.1712 None 0.999 N 0.759 0.395 0.405012372841 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
V/A 29626 Fn3-103 94 rs766178585 0.1867 -1.09 0.012 N 0.391 0.19 0.392547445146 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
V/A 29626 Fn3-103 94 rs766178585 0.1867 -1.09 0.012 N 0.391 0.19 0.392547445146 gnomAD-4.0.0 2.73772E-05 None None None None N None 0 0 None 0 0 None 0 0 3.50836E-05 0 1.65722E-05
Q/E 29829 Fn3-105 96 None 0.0864 None 0.982 N 0.516 0.312 0.221019684889 gnomAD-4.0.0 6.84816E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99999E-07 0 0
Q/H 29829 Fn3-105 96 rs1700184989 0.4277 None 0.998 N 0.661 0.164 0.222439326576 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
Q/H 29829 Fn3-105 96 rs1700184989 0.4277 None 0.998 N 0.661 0.164 0.222439326576 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
Q/K 29829 Fn3-105 96 rs1700185971 0.1583 None 0.993 N 0.535 0.352 0.211220785272 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
Q/K 29829 Fn3-105 96 rs1700185971 0.1583 None 0.993 N 0.535 0.352 0.211220785272 gnomAD-4.0.0 1.24034E-06 None None None None N None 0 1.66945E-05 None 0 0 None 0 0 0 1.10028E-05 0
K/Q 30026 Fn3-106 94 None 0.2788 None 0.976 N 0.611 0.116 0.267755039894 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
K/Q 30026 Fn3-106 94 None 0.2788 None 0.976 N 0.611 0.116 0.267755039894 gnomAD-4.0.0 6.57151E-06 None None None None N None 0 6.55222E-05 None 0 0 None 0 0 0 0 0
K/T 30026 Fn3-106 94 rs778228308 0.3706 -0.226 0.958 N 0.637 0.166 0.242244723065 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/T 30026 Fn3-106 94 rs778228308 0.3706 -0.226 0.958 N 0.637 0.166 0.242244723065 gnomAD-4.0.0 3.18248E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86549E-05 0
M/I 30516 Fn3-110 95 None 0.4312 None 0.969 N 0.583 0.315 0.560453403006 gnomAD-4.0.0 1.5936E-06 None None None None N None 0 0 None 0 2.78102E-05 None 0 0 0 0 0
M/V 30516 Fn3-110 95 None 0.1138 None 0.969 N 0.579 0.239 0.55355060856 gnomAD-4.0.0 1.59315E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86033E-06 0 0
K/T 30814 Fn3-112 96 None 0.252 None 0.999 N 0.617 0.255 0.199424873507 gnomAD-4.0.0 3.18253E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71582E-06 0 0
K/E 30915 Fn3-113 95 None 0.15 None 0.02 N 0.364 0.165 0.239901079897 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 1.01626E-03 None 0 0 None 0 0 0 0 0
V/A 31109 Fn3-114 94 rs755487582 0.2251 -1.186 0.682 N 0.477 0.259 0.368369118721 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 9.96E-05 0 None 0 None 0 0 0
V/A 31109 Fn3-114 94 rs755487582 0.2251 -1.186 0.682 N 0.477 0.259 0.368369118721 gnomAD-4.0.0 2.05254E-06 None None None None N None 0 0 None 3.82673E-05 0 None 0 0 8.99442E-07 0 1.65651E-05
V/I 31109 Fn3-114 94 None 0.0707 None 0.028 N 0.221 0.038 0.183819452728 gnomAD-4.0.0 1.36911E-06 None None None None N None 0 0 None 0 0 None 0 1.73491E-04 0 0 1.65848E-05
V/L 31109 Fn3-114 94 rs781180489 0.1594 -0.196 0.007 N 0.341 0.056 0.112648838833 gnomAD-4.0.0 1.88296E-04 None None None None N None 5.97586E-05 2.23634E-05 None 0 0 None 4.0779E-03 0 2.15887E-05 0 5.64166E-04
I/V 31205 Fn3-115 93 None 0.0754 None 0.006 N 0.115 0.059 0.30921473904 gnomAD-4.0.0 1.59126E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
M/T 31502 Fn3-117 95 None 0.1429 None 0.023 N 0.391 0.243 0.413241256734 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
T/A 31604 Fn3-118 99 None 0.0939 None 0.022 N 0.296 0.121 0.188950314367 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/P 31604 Fn3-118 99 None 0.154 None 0.981 N 0.694 0.279 0.485776496936 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 31800 Fn3-119 93 None 0.2086 None 0.025 N 0.445 0.23 0.465975295344 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.93751E-06 0 0
V/I 31800 Fn3-119 93 rs766203953 0.0603 -0.398 None N 0.058 0.099 0.206339911435 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/I 31800 Fn3-119 93 rs766203953 0.0603 -0.398 None N 0.058 0.099 0.206339911435 gnomAD-4.0.0 3.184E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86664E-05 0
S/L 31902 Fn3-120 96 rs770705757 0.069 -0.235 None N 0.258 0.135 0.455448229734 gnomAD-2.1.1 8.65E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.9E-05 0
S/L 31902 Fn3-120 96 rs770705757 0.069 -0.235 None N 0.258 0.135 0.455448229734 gnomAD-4.0.0 1.05005E-05 None None None None N None 0 0 None 0 0 None 0 0 1.09901E-05 0 5.10743E-05
L/M 32198 Fn3-122 94 None 0.1207 None 0.999 N 0.719 0.162 0.476832112026 gnomAD-4.0.0 6.84187E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65651E-05
L/V 32198 Fn3-122 94 rs752075170 0.0975 -0.666 0.997 N 0.77 0.218 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
L/V 32198 Fn3-122 94 rs752075170 0.0975 -0.666 0.997 N 0.77 0.218 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 3.16456E-03 1.47E-05 0 0
L/V 32198 Fn3-122 94 rs752075170 0.0975 -0.666 0.997 N 0.77 0.218 None gnomAD-4.0.0 3.71776E-06 None None None None N None 0 0 None 0 0 None 0 1.65017E-04 4.23798E-06 0 0
T/I 32296 Fn3-123 95 rs773279450 0.1195 0.097 0.657 N 0.622 0.197 0.362960570912 gnomAD-4.0.0 1.38575E-06 None None None None N None 3.01459E-05 0 None 0 0 None 0 0 9.09511E-07 0 0
V/I 32593 Fn3-125 95 rs763858575 0.0808 -0.214 0.036 N 0.249 0.067 0.436455679973 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
V/I 32593 Fn3-125 95 rs763858575 0.0808 -0.214 0.036 N 0.249 0.067 0.436455679973 gnomAD-4.0.0 1.1885E-05 None None None None I None 0 2.01711E-05 None 0 0 None 0 0 1.42592E-05 0 1.70952E-05
V/I 32991 Fn3-128 96 rs1416459734 0.0647 None 0.012 N 0.189 0.062 0.284150004643 gnomAD-4.0.0 3.2118E-06 None None None None I None 0 0 None 0 0 None 0 0 5.79153E-06 0 0
K/N 33092 Fn3-129 95 rs778385575 0.8023 0.236 0.693 N 0.715 0.26 0.311079019809 gnomAD-2.1.1 4.08E-06 None None None None I None 0 0 None 0 0 None 3.34E-05 None 0 0 0
K/N 33092 Fn3-129 95 rs778385575 0.8023 0.236 0.693 N 0.715 0.26 0.311079019809 gnomAD-4.0.0 1.59867E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.44388E-05 0
K/Q 33092 Fn3-129 95 None 0.2697 None 0.531 D 0.737 0.213 0.27855597813 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 33486 Fn3-131 95 rs1457955495 0.0905 -0.883 0.044 N 0.422 0.113 0.200317383148 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
T/A 33486 Fn3-131 95 rs1457955495 0.0905 -0.883 0.044 N 0.422 0.113 0.200317383148 gnomAD-4.0.0 4.77497E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57574E-06 0 0
T/I 33486 Fn3-131 95 rs1024625225 0.0551 None None N 0.178 0.059 0.119812018005 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 6.54E-05 0 0 0 None 0 0 0 0 0
T/I 33486 Fn3-131 95 rs1024625225 0.0551 None None N 0.178 0.059 0.119812018005 gnomAD-4.0.0 1.85922E-06 None None None None N None 1.33476E-05 3.33467E-05 None 0 0 None 0 0 0 0 0
T/P 33486 Fn3-131 95 None 0.2491 None 0.612 N 0.605 0.158 0.285698343383 gnomAD-4.0.0 1.59166E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43316E-05 0
T/S 33486 Fn3-131 95 None 0.1466 None 0.044 N 0.499 0.12 0.126345400529 gnomAD-4.0.0 6.84277E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15953E-05 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.