Structural position:

  • Domain Type: Fn3
  • Aligned Position: 131
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
R/K 15753 Fn3-1 97 rs577133803 0.0775 -0.468 None N 0.135 0.096 0.202086224978 gnomAD-2.1.1 8.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
R/K 15753 Fn3-1 97 rs577133803 0.0775 -0.468 None N 0.135 0.096 0.202086224978 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.95E-05 0 0
R/K 15753 Fn3-1 97 rs577133803 0.0775 -0.468 None N 0.135 0.096 0.202086224978 gnomAD-4.0.0 6.82291E-06 None None None None N None 0 0 None 0 0 None 0 0 9.3294E-06 0 0
R/T 15753 Fn3-1 97 None 0.2493 None 0.361 N 0.482 0.14 0.271763555656 gnomAD-4.0.0 6.84768E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99952E-07 0 0
D/E 15955 Fn3-3 97 None 0.2499 None 1.0 N 0.443 0.206 0.107399877778 gnomAD-4.0.0 1.37179E-06 None None None None N None 0 0 None 0 0 None 0 0 9.00846E-07 0 1.66157E-05
D/H 15955 Fn3-3 97 rs1363215463 0.4749 -0.736 1.0 N 0.79 0.389 0.207176502487 gnomAD-2.1.1 4.1E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.1E-06 0
D/H 15955 Fn3-3 97 rs1363215463 0.4749 -0.736 1.0 N 0.79 0.389 0.207176502487 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/H 15955 Fn3-3 97 rs1363215463 0.4749 -0.736 1.0 N 0.79 0.389 0.207176502487 gnomAD-4.0.0 2.57433E-06 None None None None N None 0 0 None 0 0 None 0 0 4.80568E-06 0 0
S/L 16150 Fn3-4 96 None 0.1307 None 0.657 N 0.531 0.322 0.450343601259 gnomAD-4.0.0 6.84768E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00075E-07 0 0
V/M 16250 Fn3-5 96 rs1051281754 0.139 None 0.004 N 0.366 0.064 0.278968121808 gnomAD-2.1.1 5.38E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.29E-05 0
V/M 16250 Fn3-5 96 rs1051281754 0.139 None 0.004 N 0.366 0.064 0.278968121808 gnomAD-4.0.0 3.40664E-06 None None None None N None 0 0 None 0 0 None 0 0 6.10575E-06 0 0
K/E 16445 Fn3-6 95 rs1553701901 0.3415 None 0.919 N 0.393 0.171 0.272205846399 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/E 16445 Fn3-6 95 rs1553701901 0.3415 None 0.919 N 0.393 0.171 0.272205846399 gnomAD-4.0.0 2.56791E-06 None None None None N None 3.38719E-05 0 None 0 0 None 0 0 0 0 0
R/Q 16646 Fn3-8 96 rs746384579 0.1301 0.145 0.614 N 0.338 0.175 0.126345400529 gnomAD-2.1.1 7.28E-05 None None None None N None 0 0 None 0 5.24E-05 None 1.67999E-04 None 0 1.11572E-04 0
R/Q 16646 Fn3-8 96 rs746384579 0.1301 0.145 0.614 N 0.338 0.175 0.126345400529 gnomAD-3.1.2 5.93E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.03087E-04 0 0
R/Q 16646 Fn3-8 96 rs746384579 0.1301 0.145 0.614 N 0.338 0.175 0.126345400529 gnomAD-4.0.0 3.85265E-05 None None None None N None 2.67895E-05 1.68828E-05 None 0 4.49438E-05 None 0 0 3.98937E-05 8.86761E-05 3.21337E-05
R/W 16646 Fn3-8 96 rs794729448 0.3943 -0.334 0.996 N 0.411 0.311 0.31077124679 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
R/W 16646 Fn3-8 96 rs794729448 0.3943 -0.334 0.996 N 0.411 0.311 0.31077124679 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 9.46E-05 0 0 2.07814E-04 0
R/W 16646 Fn3-8 96 rs794729448 0.3943 -0.334 0.996 N 0.411 0.311 0.31077124679 gnomAD-4.0.0 4.97106E-06 None None None None N None 0 0 None 0 0 None 3.13156E-05 0 4.24393E-06 0 1.60601E-05
K/Q 16746 Fn3-9 96 None 0.6006 None 0.999 N 0.734 0.354 0.359557344763 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
K/T 16746 Fn3-9 96 rs1367329297 0.7796 None 0.999 N 0.649 0.506 0.438593652726 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/T 16746 Fn3-9 96 rs1367329297 0.7796 None 0.999 N 0.649 0.506 0.438593652726 gnomAD-4.0.0 2.0302E-06 None None None None N None 0 0 None 0 0 None 0 0 2.41009E-06 0 0
E/G 16847 Fn3-10 97 rs760623859 0.3863 -1.08 0.003 N 0.392 0.202 0.254761474806 gnomAD-2.1.1 8.09E-06 None None None None N None 0 0 None 0 0 None 6.61E-05 None 0 0 0
E/G 16847 Fn3-10 97 rs760623859 0.3863 -1.08 0.003 N 0.392 0.202 0.254761474806 gnomAD-4.0.0 4.78643E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.8796E-05 3.03177E-05
K/E 16949 Fn3-11 98 rs1368701506 0.4043 0.222 0.992 N 0.581 0.284 0.292423486923 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/E 16949 Fn3-11 98 rs1368701506 0.4043 0.222 0.992 N 0.581 0.284 0.292423486923 gnomAD-4.0.0 1.59344E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43332E-05 0
Q/K 17142 Fn3-12 96 None 0.2344 None 0.278 N 0.297 0.101 0.162503812791 gnomAD-4.0.0 6.84643E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99836E-07 0 0
H/D 17565 Fn3-15 96 rs370126872 0.2587 0.238 0.001 N 0.245 0.082 0.141422826196 gnomAD-2.1.1 2.94E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.46E-05 0
H/D 17565 Fn3-15 96 rs370126872 0.2587 0.238 0.001 N 0.245 0.082 0.141422826196 gnomAD-3.1.2 3.29E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 5.89E-05 0 0
H/D 17565 Fn3-15 96 rs370126872 0.2587 0.238 0.001 N 0.245 0.082 0.141422826196 gnomAD-4.0.0 3.43237E-05 None None None None N None 1.34416E-05 0 None 0 0 None 1.57684E-05 4.98836E-04 4.25862E-05 0 0
H/N 17565 Fn3-15 96 None 0.1126 0.204 0.001 N 0.12 0.067 None gnomAD-2.1.1 1.85E-05 None None None None N None 0 5.92E-05 None 0 0 None 0 None 0 2.42E-05 0
H/N 17565 Fn3-15 96 None 0.1126 0.204 0.001 N 0.12 0.067 None gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
H/N 17565 Fn3-15 96 None 0.1126 0.204 0.001 N 0.12 0.067 None gnomAD-4.0.0 4.99254E-06 None None None None N None 0 5.1212E-05 None 0 0 None 0 0 4.25861E-06 0 0
H/Q 17565 Fn3-15 96 None 0.0833 None None N 0.069 0.089 0.0920862733494 gnomAD-4.0.0 1.61956E-06 None None None None N None 0 0 None 0 0 None 0 0 2.90402E-06 0 0
H/R 17565 Fn3-15 96 None 0.0612 None None N 0.056 0.147 0.0482279557977 gnomAD-4.0.0 1.62009E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.07977E-05
H/Y 17565 Fn3-15 96 rs370126872 0.0975 0.671 0.006 N 0.173 0.101 0.180583059064 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 17857 Fn3-17 94 rs1352428551 0.2604 -0.566 0.236 N 0.215 0.088 0.338834610459 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.49E-05 0
V/A 17857 Fn3-17 94 rs1352428551 0.2604 -0.566 0.236 N 0.215 0.088 0.338834610459 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 17857 Fn3-17 94 rs1352428551 0.2604 -0.566 0.236 N 0.215 0.088 0.338834610459 gnomAD-4.0.0 5.15981E-06 None None None None I None 0 0 None 0 0 None 0 0 9.60841E-06 0 0
V/F 17857 Fn3-17 94 rs1423994048 0.4165 -0.864 0.998 N 0.294 0.321 0.721568202884 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
V/F 17857 Fn3-17 94 rs1423994048 0.4165 -0.864 0.998 N 0.294 0.321 0.721568202884 gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
V/F 17857 Fn3-17 94 rs1423994048 0.4165 -0.864 0.998 N 0.294 0.321 0.721568202884 gnomAD-4.0.0 1.86471E-06 None None None None I None 4.02555E-05 0 None 0 0 None 0 0 0 0 0
V/I 17857 Fn3-17 94 rs1423994048 0.0907 -0.251 0.979 N 0.42 0.115 0.360961692134 gnomAD-2.1.1 1.23E-05 None None None None I None 0 8.94E-05 None 0 0 None 0 None 0 0 0
V/I 17857 Fn3-17 94 rs1423994048 0.0907 -0.251 0.979 N 0.42 0.115 0.360961692134 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
V/I 17857 Fn3-17 94 rs1423994048 0.0907 -0.251 0.979 N 0.42 0.115 0.360961692134 gnomAD-4.0.0 3.72942E-06 None None None None I None 0 1.01826E-04 None 0 0 None 0 0 0 0 0
V/L 17857 Fn3-17 94 None 0.3292 None 0.905 N 0.411 0.169 0.262662153117 gnomAD-4.0.0 6.86396E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00589E-07 0 0
D/Y 17958 Fn3-18 97 None 0.9241 None 1.0 N 0.782 0.527 0.626665467207 gnomAD-4.0.0 1.65127E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.51355E-05 0
G/E 18267 Fn3-20 102 rs878876923 0.1467 None 0.013 N 0.541 0.166 0.275641507738 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/E 18267 Fn3-20 102 rs878876923 0.1467 None 0.013 N 0.541 0.166 0.275641507738 gnomAD-4.0.0 2.61866E-06 None None None None N None 0 0 None 0 0 None 0 0 4.92858E-06 0 0
R/G 18574 Fn3-22 96 rs2053379995 0.6047 None 0.999 N 0.656 0.266 0.383590876969 gnomAD-4.0.0 1.23239E-05 None None None None N None 0 0 None 0 1.98323E-04 None 0 0 0 0 0
R/S 18574 Fn3-22 96 None 0.7367 None 0.999 N 0.721 0.223 0.248417906384 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/E 18680 Fn3-23 102 None 0.208 None None N None 0.17 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/G 18984 Fn3-25 101 None 0.4479 None 0.999 N 0.665 0.251 0.429780353351 gnomAD-4.0.0 6.85385E-07 None None None None N None 0 0 None 0 2.5227E-05 None 0 0 0 0 0
R/T 18984 Fn3-25 101 None 0.3472 None 0.999 N 0.749 0.351 0.430351802785 gnomAD-4.0.0 2.0539E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69931E-06 0 0
K/T 19084 Fn3-26 97 rs1445268725 0.2675 -0.662 0.986 N 0.681 0.401 0.32714864917 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/T 19084 Fn3-26 97 rs1445268725 0.2675 -0.662 0.986 N 0.681 0.401 0.32714864917 gnomAD-4.0.0 1.59256E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43394E-05 0
R/G 19279 Fn3-27 97 None 0.3069 None 0.651 N 0.425 0.198 0.517432700143 gnomAD-4.0.0 1.75052E-06 None None None None N None 0 0 None 0 0 None 0 0 3.13042E-06 0 0
K/T 19380 Fn3-28 97 rs1245279855 0.4828 -0.11 0.883 N 0.502 0.202 0.260249123532 gnomAD-2.1.1 4.3E-06 None None None None N None 0 0 None 0 0 None 3.83E-05 None 0 0 0
K/T 19380 Fn3-28 97 rs1245279855 0.4828 -0.11 0.883 N 0.502 0.202 0.260249123532 gnomAD-4.0.0 1.64569E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.52064E-05 0
K/E 19574 Fn3-29 96 rs1032128606 0.2018 None 0.104 N 0.431 0.246 0.27132560031 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/E 19574 Fn3-29 96 rs1032128606 0.2018 None 0.104 N 0.431 0.246 0.27132560031 gnomAD-4.0.0 6.57376E-06 None None None None N None 2.41266E-05 0 None 0 0 None 0 0 0 0 0
L/F 19972 Fn3-32 96 rs1553645773 0.1495 None 0.026 N 0.339 0.035 0.265929055128 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
L/F 19972 Fn3-32 96 rs1553645773 0.1495 None 0.026 N 0.339 0.035 0.265929055128 gnomAD-4.0.0 3.18893E-06 None None None None N None 5.67859E-05 0 None 0 0 None 0 0 2.86138E-06 0 0
Q/H 20070 Fn3-33 94 rs1204026103 0.2743 None 0.998 N 0.499 0.172 0.348764635752 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/E 20266 Fn3-34 96 rs763212024 0.1488 -1.98 0.06 N 0.143 0.142 None gnomAD-2.1.1 1.61E-05 None None None None N None 1.29282E-04 5.8E-05 None 0 0 None 0 None 0 0 0
K/E 20266 Fn3-34 96 rs763212024 0.1488 -1.98 0.06 N 0.143 0.142 None gnomAD-3.1.2 2.63E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
K/E 20266 Fn3-34 96 rs763212024 0.1488 -1.98 0.06 N 0.143 0.142 None gnomAD-4.0.0 6.81953E-06 None None None None N None 1.06846E-04 3.33578E-05 None 0 0 None 0 0 8.47923E-07 0 0
C/S 20366 Fn3-35 96 rs200101317 0.1578 -0.555 0.01 N 0.142 0.148 0.369495900351 gnomAD-2.1.1 2.86E-05 None None None None N None 0 8.5E-05 None 0 0 None 0 None 0 3.91E-05 0
C/S 20366 Fn3-35 96 rs200101317 0.1578 -0.555 0.01 N 0.142 0.148 0.369495900351 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 7.36E-05 0 0
C/S 20366 Fn3-35 96 rs200101317 0.1578 -0.555 0.01 N 0.142 0.148 0.369495900351 gnomAD-4.0.0 2.66591E-05 None None None None N None 0 1.00097E-04 None 0 0 None 0 0 2.96764E-05 0 3.20297E-05
C/Y 20366 Fn3-35 96 rs2050006408 0.1949 None 0.976 N 0.575 0.232 0.51230852224 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
I/T 20663 Fn3-37 95 rs1297355642 0.5184 -0.58 0.976 N 0.51 0.291 0.524584940466 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/T 20663 Fn3-37 95 rs1297355642 0.5184 -0.58 0.976 N 0.51 0.291 0.524584940466 gnomAD-4.0.0 1.5917E-06 None None None None N None 0 2.28686E-05 None 0 0 None 0 0 0 0 0
I/V 20663 Fn3-37 95 None 0.0932 None 0.188 N 0.138 0.105 0.362160248664 gnomAD-4.0.0 6.84298E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99575E-06 0 0
E/Q 20764 Fn3-38 97 rs397517651 0.6366 -0.259 0.999 N 0.649 0.298 None gnomAD-2.1.1 1.43E-05 None None None None N None 1.65344E-04 0 None 0 0 None 0 None 0 0 0
E/Q 20764 Fn3-38 97 rs397517651 0.6366 -0.259 0.999 N 0.649 0.298 None gnomAD-3.1.2 6.58E-05 None None None None N None 2.41371E-04 0 0 0 0 None 0 0 0 0 0
E/Q 20764 Fn3-38 97 rs397517651 0.6366 -0.259 0.999 N 0.649 0.298 None gnomAD-4.0.0 1.11574E-05 None None None None N None 2.40359E-04 0 None 0 0 None 0 0 0 0 0
K/E 20958 Fn3-39 95 None 0.298 None 0.991 N 0.488 0.176 0.258283824007 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/R 20958 Fn3-39 95 rs2049627530 0.0787 None 0.451 N 0.297 0.116 0.168933306366 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
K/R 20958 Fn3-39 95 rs2049627530 0.0787 None 0.451 N 0.297 0.116 0.168933306366 gnomAD-4.0.0 6.57635E-06 None None None None N None 0 6.55394E-05 None 0 0 None 0 0 0 0 0
K/E 21059 Fn3-40 97 None 0.3962 None 0.997 N 0.648 0.275 0.285698343383 gnomAD-4.0.0 1.45525E-06 None None None None N None 3.2817E-05 0 None 0 0 None 0 0 9.31982E-07 0 0
K/T 21166 Fn3-41 103 rs1315515272 0.1532 -0.388 0.999 N 0.701 0.259 0.246773566709 gnomAD-2.1.1 4.42E-06 None None None None N None 0 0 None 0 0 None 3.6E-05 None 0 0 0
K/T 21166 Fn3-41 103 rs1315515272 0.1532 -0.388 0.999 N 0.701 0.259 0.246773566709 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
K/T 21166 Fn3-41 103 rs1315515272 0.1532 -0.388 0.999 N 0.701 0.259 0.246773566709 gnomAD-4.0.0 6.57834E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.06954E-04 0
K/R 21462 Fn3-43 97 rs1275082313 0.0881 -0.095 0.997 D 0.634 0.204 0.467161347466 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
K/R 21462 Fn3-43 97 rs1275082313 0.0881 -0.095 0.997 D 0.634 0.204 0.467161347466 gnomAD-4.0.0 1.36914E-06 None None None None N None 0 0 None 0 2.52411E-05 None 0 0 0 0 1.65761E-05
K/T 21462 Fn3-43 97 None 0.3528 None 0.999 N 0.671 0.453 0.457922657367 gnomAD-4.0.0 6.8457E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99842E-07 0 0
K/R 22050 Fn3-47 95 rs2047964470 0.0787 None 0.988 N 0.562 0.214 0.347659731818 gnomAD-4.0.0 3.32615E-06 None None None None N None 0 0 None 0 5.60036E-05 None 0 0 0 0 0
R/L 22151 Fn3-48 97 None 0.1446 None None N 0.04 0.064 0.238705975628 gnomAD-4.0.0 6.8453E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.1599E-05 0
R/P 22151 Fn3-48 97 rs781750042 0.9183 0.099 0.076 N 0.493 0.088 0.185906805712 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
R/P 22151 Fn3-48 97 rs781750042 0.9183 0.099 0.076 N 0.493 0.088 0.185906805712 gnomAD-4.0.0 2.05359E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79946E-06 1.15988E-05 0
R/Q 22151 Fn3-48 97 rs781750042 0.0854 0.277 None N 0.043 0.1 0.0986583533028 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
R/Q 22151 Fn3-48 97 rs781750042 0.0854 0.277 None N 0.043 0.1 0.0986583533028 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/Q 22151 Fn3-48 97 rs781750042 0.0854 0.277 None N 0.043 0.1 0.0986583533028 gnomAD-4.0.0 4.3399E-06 None None None None N None 2.67165E-05 0 None 0 0 None 0 0 3.39146E-06 0 1.602E-05
R/W 22151 Fn3-48 97 rs748238939 0.1751 -0.282 0.88 N 0.247 0.244 0.417081434665 gnomAD-2.1.1 1.61E-05 None None None None N None 6.47E-05 0 None 0 0 None 9.8E-05 None 0 0 0
R/W 22151 Fn3-48 97 rs748238939 0.1751 -0.282 0.88 N 0.247 0.244 0.417081434665 gnomAD-4.0.0 1.02678E-05 None None None None N None 1.19689E-04 2.23834E-05 None 0 0 None 0 0 8.99727E-07 1.04391E-04 0
L/P 22839 Fn3-53 97 None 0.9716 None 1.0 N 0.736 0.526 0.794652452828 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
L/V 22839 Fn3-53 97 None 0.1379 None 0.997 N 0.569 0.183 0.467329424371 gnomAD-4.0.0 1.5935E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86138E-06 0 0
K/M 22938 Fn3-54 98 rs2046738934 0.3626 None 0.994 N 0.634 0.302 0.298403945805 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/M 22938 Fn3-54 98 rs2046738934 0.3626 None 0.994 N 0.634 0.302 0.298403945805 gnomAD-4.0.0 3.88038E-06 None None None None N None 0 0 None 0 0 None 0 0 7.23917E-06 0 0
V/I 23134 Fn3-55 95 rs1373489781 0.0822 None 0.501 N 0.409 0.073 0.540561900723 gnomAD-4.0.0 1.37114E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80152E-06 0 0
V/L 23134 Fn3-55 95 rs1373489781 0.1911 -0.474 0.293 N 0.367 0.096 0.432041664125 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.67392E-04
V/L 23134 Fn3-55 95 rs1373489781 0.1911 -0.474 0.293 N 0.367 0.096 0.432041664125 gnomAD-4.0.0 6.85572E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.66058E-05
E/K 23337 Fn3-57 98 None 0.6806 None 0.001 N 0.215 0.146 0.252681307341 gnomAD-4.0.0 1.59197E-06 None None None None N None 0 0 None 0 2.77824E-05 None 0 0 0 0 0
E/Q 23337 Fn3-57 98 rs1709996308 0.4417 None 0.181 D 0.58 0.138 0.301122078929 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/Q 23337 Fn3-57 98 rs1709996308 0.4417 None 0.181 D 0.58 0.138 0.301122078929 gnomAD-4.0.0 2.56339E-06 None None None None N None 1.69222E-05 0 None 0 0 None 0 0 2.39402E-06 0 0
N/T 23821 Fn3-60 96 None 0.0911 None None N 0.047 0.07 0.0954503805726 gnomAD-4.0.0 1.59253E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86012E-06 0 0
R/K 24021 Fn3-62 98 rs1709204833 0.0836 None 0.991 N 0.496 0.199 0.104622674875 gnomAD-4.0.0 1.59209E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86008E-06 0 0
C/R 24318 Fn3-64 97 rs1443412363 0.1574 0.121 0.744 N 0.642 0.231 0.713796121269 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.97E-06 0
C/R 24318 Fn3-64 97 rs1443412363 0.1574 0.121 0.744 N 0.642 0.231 0.713796121269 gnomAD-4.0.0 2.74149E-06 None None None None N None 0 0 None 0 0 None 0 0 3.60225E-06 0 0
E/K 24420 Fn3-65 98 rs1265445775 0.1605 None 0.032 N 0.265 0.324 0.243398259712 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/K 24420 Fn3-65 98 rs1265445775 0.1605 None 0.032 N 0.265 0.324 0.243398259712 gnomAD-4.0.0 7.69014E-06 None None None None N None 3.38284E-05 0 None 0 0 None 0 0 0 0 1.13837E-04
S/A 24614 Fn3-66 96 None 0.0731 None 0.99 N 0.472 0.157 0.236278675362 gnomAD-4.0.0 2.05445E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.47987E-05 0
S/P 24614 Fn3-66 96 rs759970555 0.9923 0.199 1.0 N 0.695 0.312 0.297031009988 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/P 24614 Fn3-66 96 rs759970555 0.9923 0.199 1.0 N 0.695 0.312 0.297031009988 gnomAD-4.0.0 6.84817E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15996E-05 0
K/T 24710 Fn3-67 95 None 0.4952 None 0.997 N 0.646 0.515 0.457377140028 gnomAD-4.0.0 1.59243E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85964E-06 0 0
R/C 25004 Fn3-69 97 rs1320326326 0.1747 -0.333 0.984 N 0.85 0.218 0.300784259202 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
R/C 25004 Fn3-69 97 rs1320326326 0.1747 -0.333 0.984 N 0.85 0.218 0.300784259202 gnomAD-3.1.2 3.29E-05 None None None None N None 9.66E-05 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 25004 Fn3-69 97 rs1320326326 0.1747 -0.333 0.984 N 0.85 0.218 0.300784259202 gnomAD-4.0.0 6.19869E-06 None None None None N None 5.34202E-05 1.66756E-05 None 0 0 None 0 0 3.39099E-06 1.09798E-05 0
R/G 25004 Fn3-69 97 rs1320326326 0.4634 -0.765 0.249 N 0.533 0.143 0.251639045875 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
R/G 25004 Fn3-69 97 rs1320326326 0.4634 -0.765 0.249 N 0.533 0.143 0.251639045875 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/G 25004 Fn3-69 97 rs1320326326 0.4634 -0.765 0.249 N 0.533 0.143 0.251639045875 gnomAD-4.0.0 1.85961E-06 None None None None N None 1.33551E-05 0 None 0 0 None 0 0 1.6955E-06 0 0
R/H 25004 Fn3-69 97 rs909041164 0.1274 -1.062 0.002 N 0.202 0.185 0.233150807113 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
R/H 25004 Fn3-69 97 rs909041164 0.1274 -1.062 0.002 N 0.202 0.185 0.233150807113 gnomAD-3.1.2 1.97E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 2.94E-05 0 0
R/H 25004 Fn3-69 97 rs909041164 0.1274 -1.062 0.002 N 0.202 0.185 0.233150807113 gnomAD-4.0.0 1.85961E-05 None None None None N None 2.6713E-05 1.66744E-05 None 0 0 None 0 0 1.9498E-05 2.19616E-05 3.20318E-05
R/K 25103 Fn3-70 98 rs758786845 0.0904 -0.545 None N 0.147 0.098 0.0920862733494 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 4.64E-05 0 0
R/K 25103 Fn3-70 98 rs758786845 0.0904 -0.545 None N 0.147 0.098 0.0920862733494 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.42E-05 0 0 0 0
R/K 25103 Fn3-70 98 rs758786845 0.0904 -0.545 None N 0.147 0.098 0.0920862733494 gnomAD-4.0.0 3.8445E-06 None None None None N None 0 0 None 0 0 None 4.70751E-05 0 0 0 0
R/T 25103 Fn3-70 98 rs758786845 0.4255 -0.367 0.501 N 0.484 0.159 0.173771789658 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 8.9E-06 0
R/T 25103 Fn3-70 98 rs758786845 0.4255 -0.367 0.501 N 0.484 0.159 0.173771789658 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93573E-04 None 0 0 0 0 0
R/T 25103 Fn3-70 98 rs758786845 0.4255 -0.367 0.501 N 0.484 0.159 0.173771789658 gnomAD-4.0.0 6.4075E-06 None None None None N None 0 0 None 0 7.28226E-05 None 0 0 4.7876E-06 0 0
K/N 25299 Fn3-71 96 rs754354789 0.4898 0.202 0.651 N 0.334 0.337 0.263140351381 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 0 0
K/N 25299 Fn3-71 96 rs754354789 0.4898 0.202 0.651 N 0.334 0.337 0.263140351381 gnomAD-4.0.0 9.55222E-06 None None None None N None 0 0 None 0 0 None 0 0 0 8.59796E-05 0
K/Q 25299 Fn3-71 96 None 0.1123 None 0.651 N 0.455 0.133 0.209622950755 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
C/R 25400 Fn3-72 97 rs1575727915 0.1461 None 0.001 N 0.231 0.319 0.40218521252 gnomAD-4.0.0 1.59287E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86077E-06 0 0
C/S 25400 Fn3-72 97 rs397517704 0.1286 -0.534 0.003 N 0.154 0.304 0.350307294319 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
C/S 25400 Fn3-72 97 rs397517704 0.1286 -0.534 0.003 N 0.154 0.304 0.350307294319 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
C/S 25400 Fn3-72 97 rs397517704 0.1286 -0.534 0.003 N 0.154 0.304 0.350307294319 gnomAD-4.0.0 1.05401E-05 None None None None N None 0 0 None 0 0 None 0 0 1.3566E-05 0 1.60226E-05
C/W 25400 Fn3-72 97 None 0.3358 None 0.973 N 0.527 0.286 0.277317399466 gnomAD-4.0.0 6.37135E-06 None None None None N None 0 0 None 0 0 None 0 0 1.14429E-05 0 0
Q/P 25985 Fn3-76 96 rs552211406 0.8899 -0.226 0.956 N 0.415 0.375 0.28722502521 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
Q/P 25985 Fn3-76 96 rs552211406 0.8899 -0.226 0.956 N 0.415 0.375 0.28722502521 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 0 4.1425E-04 0
Q/P 25985 Fn3-76 96 rs552211406 0.8899 -0.226 0.956 N 0.415 0.375 0.28722502521 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
Q/P 25985 Fn3-76 96 rs552211406 0.8899 -0.226 0.956 N 0.415 0.375 0.28722502521 gnomAD-4.0.0 1.17755E-05 None None None None N None 0 0 None 0 0 None 0 0 2.54332E-06 1.64701E-04 1.60087E-05
R/K 26086 Fn3-77 97 rs1394737177 0.1605 -0.124 0.894 N 0.497 0.111 0.250039746154 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
K/N 26185 Fn3-78 98 rs1474159938 0.8337 -0.044 0.449 N 0.581 0.17 0.15556083564 gnomAD-2.1.1 4.06E-06 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 0 0
K/N 26185 Fn3-78 98 rs1474159938 0.8337 -0.044 0.449 N 0.581 0.17 0.15556083564 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
K/N 26185 Fn3-78 98 rs1474159938 0.8337 -0.044 0.449 N 0.581 0.17 0.15556083564 gnomAD-4.0.0 3.86422E-06 None None None None N None 5.08302E-05 0 None 0 0 None 0 0 0 0 0
K/R 26185 Fn3-78 98 rs1455158405 0.0708 -0.155 0.001 N 0.235 0.054 0.126345400529 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
K/R 26185 Fn3-78 98 rs1455158405 0.0708 -0.155 0.001 N 0.235 0.054 0.126345400529 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/R 26185 Fn3-78 98 rs1455158405 0.0708 -0.155 0.001 N 0.235 0.054 0.126345400529 gnomAD-4.0.0 2.02998E-06 None None None None N None 3.49455E-05 0 None 0 0 None 0 0 0 0 0
A/D 26778 Fn3-82 96 rs1463558062 0.8414 -0.433 0.186 N 0.6 0.154 0.289474373501 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
A/D 26778 Fn3-82 96 rs1463558062 0.8414 -0.433 0.186 N 0.6 0.154 0.289474373501 gnomAD-4.0.0 4.10564E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39738E-06 0 0
K/E 26874 Fn3-83 95 rs372155974 0.3554 0.337 0.059 D 0.506 0.231 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
K/E 26874 Fn3-83 95 rs372155974 0.3554 0.337 0.059 D 0.506 0.231 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/E 26874 Fn3-83 95 rs372155974 0.3554 0.337 0.059 D 0.506 0.231 None gnomAD-4.0.0 6.57531E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47089E-05 0 0
K/T 26874 Fn3-83 95 None 0.3489 None 0.059 N 0.661 0.259 0.319970858106 gnomAD-4.0.0 2.7373E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59835E-06 0 0
Q/K 27067 Fn3-84 96 rs1315059139 0.1134 -1.228 0.003 N 0.225 0.141 0.0954503805726 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 3.3E-05 None 0 1.79E-05 0
Q/K 27067 Fn3-84 96 rs1315059139 0.1134 -1.228 0.003 N 0.225 0.141 0.0954503805726 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/K 27067 Fn3-84 96 rs1315059139 0.1134 -1.228 0.003 N 0.225 0.141 0.0954503805726 gnomAD-4.0.0 7.70009E-06 None None None None N None 0 0 None 0 0 None 0 0 1.19798E-05 1.34488E-05 0
R/C 27168 Fn3-85 97 rs377616334 0.2784 -0.292 1.0 N 0.893 0.311 None gnomAD-2.1.1 2.86E-05 None None None None N None 2.06731E-04 5.67E-05 None 0 0 None 0 None 0 7.83E-06 0
R/C 27168 Fn3-85 97 rs377616334 0.2784 -0.292 1.0 N 0.893 0.311 None gnomAD-3.1.2 2.63E-05 None None None None N None 9.66E-05 0 0 0 0 None 0 0 0 0 0
R/C 27168 Fn3-85 97 rs377616334 0.2784 -0.292 1.0 N 0.893 0.311 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
R/C 27168 Fn3-85 97 rs377616334 0.2784 -0.292 1.0 N 0.893 0.311 None gnomAD-4.0.0 8.67691E-06 None None None None N None 1.46682E-04 1.66756E-05 None 0 0 None 0 0 1.69536E-06 0 0
R/G 27168 Fn3-85 97 rs377616334 0.7317 -0.722 1.0 N 0.674 0.282 0.471620082127 gnomAD-2.1.1 8.06E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
R/G 27168 Fn3-85 97 rs377616334 0.7317 -0.722 1.0 N 0.674 0.282 0.471620082127 gnomAD-4.0.0 1.36865E-06 None None None None N None 0 4.47487E-05 None 0 0 None 0 0 0 0 0
R/H 27168 Fn3-85 97 rs374160272 0.2122 -1.029 1.0 N 0.823 0.424 None gnomAD-2.1.1 3.93E-05 None None None None N None 8.27E-05 2.83E-05 None 0 0 None 1.30753E-04 None 0 2.35E-05 1.40647E-04
R/H 27168 Fn3-85 97 rs374160272 0.2122 -1.029 1.0 N 0.823 0.424 None gnomAD-3.1.2 5.26E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 7.35E-05 0 0
R/H 27168 Fn3-85 97 rs374160272 0.2122 -1.029 1.0 N 0.823 0.424 None gnomAD-4.0.0 3.78077E-05 None None None None N None 8.01218E-05 1.66795E-05 None 0 2.23324E-05 None 0 0 3.30593E-05 6.58776E-05 1.28115E-04
R/K 27267 Fn3-86 98 rs975294048 0.0891 None 0.029 N 0.113 0.169 0.12205267543 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/K 27267 Fn3-86 98 rs975294048 0.0891 None 0.029 N 0.113 0.169 0.12205267543 gnomAD-4.0.0 1.31499E-05 None None None None N None 0 0 None 0 0 None 0 0 2.94109E-05 0 0
C/R 27464 Fn3-87 96 rs1704578437 0.0587 None None N 0.075 0.154 0.199424873507 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
C/R 27464 Fn3-87 96 rs1704578437 0.0587 None None N 0.075 0.154 0.199424873507 gnomAD-4.0.0 6.57497E-06 None None None None N None 0 6.55996E-05 None 0 0 None 0 0 0 0 0
C/Y 27565 Fn3-88 97 rs1408346565 0.2855 -1.176 0.999 N 0.814 0.333 0.693611638501 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
C/Y 27565 Fn3-88 97 rs1408346565 0.2855 -1.176 0.999 N 0.814 0.333 0.693611638501 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/F 27861 Fn3-90 96 None 0.5795 None 1.0 N 0.715 0.333 0.498641525541 gnomAD-4.0.0 3.19901E-06 None None None None N None 0 0 None 0 0 None 0 0 5.73506E-06 0 0
R/K 27957 Fn3-91 95 rs148067743 0.0682 -0.366 None N 0.081 0.112 None gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
R/K 27957 Fn3-91 95 rs148067743 0.0682 -0.366 None N 0.081 0.112 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/K 27957 Fn3-91 95 rs148067743 0.0682 -0.366 None N 0.081 0.112 None gnomAD-4.0.0 1.85949E-06 None None None None N None 1.33294E-05 0 None 0 0 None 0 0 1.69547E-06 0 0
R/M 27957 Fn3-91 95 None 0.3343 None 0.57 N 0.369 0.127 0.210429274316 gnomAD-4.0.0 6.84421E-07 None None None None N None 0 0 None 0 0 None 1.87554E-05 0 0 0 0
R/T 27957 Fn3-91 95 rs148067743 0.2681 -0.326 0.058 N 0.383 0.082 0.185906805712 gnomAD-2.1.1 1.45153E-04 None None None None N None 0 8.71536E-04 None 0 0 None 0 None 0 4.45E-05 1.66279E-04
R/T 27957 Fn3-91 95 rs148067743 0.2681 -0.326 0.058 N 0.383 0.082 0.185906805712 gnomAD-3.1.2 1.51183E-04 None None None None N None 4.83E-05 9.17071E-04 0 0 0 None 0 0 2.94E-05 0 2.39234E-03
R/T 27957 Fn3-91 95 rs148067743 0.2681 -0.326 0.058 N 0.383 0.082 0.185906805712 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 0 2E-03 None None None 0 None
R/T 27957 Fn3-91 95 rs148067743 0.2681 -0.326 0.058 N 0.383 0.082 0.185906805712 gnomAD-4.0.0 6.07436E-05 None None None None N None 5.33177E-05 9.50444E-04 None 0 0 None 0 0 2.45844E-05 0 1.28078E-04
L/V 28545 Fn3-95 96 None 0.0615 None 0.003 N 0.241 0.079 0.27855597813 gnomAD-4.0.0 6.84519E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99713E-07 0 0
T/A 28940 Fn3-98 96 rs748476449 0.1372 -0.782 0.997 N 0.482 0.285 0.144782658237 gnomAD-2.1.1 1.14E-05 None None None None N None 1.25786E-04 0 None 0 0 None 0 None 0 0 0
T/A 28940 Fn3-98 96 rs748476449 0.1372 -0.782 0.997 N 0.482 0.285 0.144782658237 gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
T/A 28940 Fn3-98 96 rs748476449 0.1372 -0.782 0.997 N 0.482 0.285 0.144782658237 gnomAD-4.0.0 5.67686E-06 None None None None N None 1.22386E-04 0 None 0 0 None 0 0 0 0 0
T/I 28940 Fn3-98 96 None 0.5078 None 0.999 N 0.612 0.361 0.340273420219 gnomAD-4.0.0 1.6663E-06 None None None None N None 0 0 None 0 0 None 0 0 2.97869E-06 0 0
K/N 29036 Fn3-99 95 None 0.693 None 0.999 D 0.705 0.346 0.340032825777 gnomAD-4.0.0 6.85198E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99881E-07 0 0
I/L 29333 Fn3-101 97 rs1701876010 0.1744 None 0.985 N 0.353 0.291 0.440810947182 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/L 29333 Fn3-101 97 rs1701876010 0.1744 None 0.985 N 0.353 0.291 0.440810947182 gnomAD-4.0.0 6.5703E-06 None None None None N None 2.41208E-05 0 None 0 0 None 0 0 0 0 0
I/T 29333 Fn3-101 97 rs764532002 0.2677 -0.694 0.999 N 0.649 0.425 0.519837540645 gnomAD-2.1.1 1.21E-05 None None None None N None 0 2.9E-05 None 0 0 None 3.27E-05 None 0 8.91E-06 0
I/T 29333 Fn3-101 97 rs764532002 0.2677 -0.694 0.999 N 0.649 0.425 0.519837540645 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07297E-04 0
I/T 29333 Fn3-101 97 rs764532002 0.2677 -0.694 0.999 N 0.649 0.425 0.519837540645 gnomAD-4.0.0 1.23934E-05 None None None None N None 0 1.66644E-05 None 0 0 None 0 0 1.18658E-05 4.39174E-05 1.60123E-05
I/V 29333 Fn3-101 97 rs1701876010 0.093 None 0.985 N 0.305 0.202 0.44153150616 gnomAD-4.0.0 4.78942E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39654E-06 0 1.65673E-05
I/V 29432 Fn3-102 98 rs775025065 0.0714 -0.268 None N 0.06 0.058 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
I/V 29432 Fn3-102 98 rs775025065 0.0714 -0.268 None N 0.06 0.058 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 29432 Fn3-102 98 rs775025065 0.0714 -0.268 None N 0.06 0.058 None gnomAD-4.0.0 5.57805E-05 None None None None N None 0 0 None 0 0 None 0 0 7.45884E-05 0 3.20236E-05
K/R 29628 Fn3-103 96 rs1366016395 0.0733 0.146 0.005 N 0.303 0.049 0.101711395817 gnomAD-2.1.1 8.09E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
K/R 29628 Fn3-103 96 rs1366016395 0.0733 0.146 0.005 N 0.303 0.049 0.101711395817 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/R 29628 Fn3-103 96 rs1366016395 0.0733 0.146 0.005 N 0.303 0.049 0.101711395817 gnomAD-4.0.0 3.71933E-06 None None None None N None 0 0 None 0 0 None 0 0 5.08646E-06 0 0
K/E 29831 Fn3-105 98 rs774632104 0.3027 0.276 0.997 N 0.691 0.214 0.297718772494 gnomAD-2.1.1 3.25E-05 None None None None N None 0 5.71E-05 None 0 5.13E-05 None 0 None 0 4.73E-05 0
K/E 29831 Fn3-105 98 rs774632104 0.3027 0.276 0.997 N 0.691 0.214 0.297718772494 gnomAD-3.1.2 4.6E-05 None None None None N None 0 1.96309E-04 0 0 3.8506E-04 None 0 0 2.94E-05 0 0
K/E 29831 Fn3-105 98 rs774632104 0.3027 0.276 0.997 N 0.691 0.214 0.297718772494 gnomAD-4.0.0 6.39671E-05 None None None None N None 0 8.38223E-05 None 0 7.13649E-04 None 0 0 5.43267E-05 0 3.21295E-05
K/T 29831 Fn3-105 98 rs1404072291 0.2809 None 0.999 N 0.641 0.252 0.31411915649 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 4.77555E-04
K/T 29831 Fn3-105 98 rs1404072291 0.2809 None 0.999 N 0.641 0.252 0.31411915649 gnomAD-4.0.0 5.14775E-06 None None None None N None 0 0 None 0 0 None 0 0 7.20946E-06 0 2.86205E-05
K/E 30123 Fn3-107 94 rs777314679 0.3502 0.335 0.92 N 0.455 0.204 0.253205268125 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
K/E 30123 Fn3-107 94 rs777314679 0.3502 0.335 0.92 N 0.455 0.204 0.253205268125 gnomAD-4.0.0 1.36848E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79893E-06 0 0
K/N 30319 Fn3-108 96 rs1171847318 0.5178 -2.149 0.361 N 0.651 0.211 0.146414634003 gnomAD-4.0.0 1.59299E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86316E-06 0 0
V/A 30420 Fn3-109 97 rs779547880 0.3571 -0.768 0.163 N 0.345 0.237 0.339074221408 gnomAD-2.1.1 4.41E-06 None None None None N None 0 0 None 0 0 None 3.97E-05 None 0 0 0
V/A 30420 Fn3-109 97 rs779547880 0.3571 -0.768 0.163 N 0.345 0.237 0.339074221408 gnomAD-4.0.0 1.68418E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.55739E-05 0
V/D 30420 Fn3-109 97 rs779547880 0.9068 -0.097 0.771 N 0.828 0.351 0.695650398914 gnomAD-2.1.1 4.41E-06 None None None None N None 0 3.35E-05 None 0 0 None 0 None 0 0 0
V/D 30420 Fn3-109 97 rs779547880 0.9068 -0.097 0.771 N 0.828 0.351 0.695650398914 gnomAD-4.0.0 1.68418E-06 None None None None N None 0 2.6077E-05 None 0 0 None 0 0 0 0 0
V/F 30420 Fn3-109 97 None 0.3646 None 0.624 N 0.525 0.124 0.585382094262 gnomAD-4.0.0 2.40095E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62535E-06 0 0
R/G 30518 Fn3-110 97 None 0.499 None 0.958 N 0.593 0.336 0.586816528483 gnomAD-4.0.0 3.18731E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72122E-06 0 0
V/A 30917 Fn3-113 97 rs748545482 0.1004 -0.779 0.003 N 0.143 0.153 0.445410361449 gnomAD-2.1.1 2.81E-05 None None None None N None 0 0 None 0 0 None 2.28743E-04 None 0 0 0
V/A 30917 Fn3-113 97 rs748545482 0.1004 -0.779 0.003 N 0.143 0.153 0.445410361449 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07383E-04 0
V/A 30917 Fn3-113 97 rs748545482 0.1004 -0.779 0.003 N 0.143 0.153 0.445410361449 gnomAD-4.0.0 2.29297E-05 None None None None N None 0 0 None 0 2.22946E-05 None 0 0 8.47588E-07 3.73298E-04 1.60108E-05
V/I 30917 Fn3-113 97 None 0.0673 None 0.003 N 0.227 0.065 0.355865052028 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 31111 Fn3-114 96 None 0.1265 None 0.997 N 0.48 0.329 0.171388866994 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 31403 Fn3-116 96 rs746139438 0.1979 -0.821 0.603 N 0.229 0.279 0.207176502487 gnomAD-2.1.1 8.47E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.88E-05 0
E/K 31403 Fn3-116 96 rs746139438 0.1979 -0.821 0.603 N 0.229 0.279 0.207176502487 gnomAD-4.0.0 2.76615E-06 None None None None N None 0 0 None 0 0 None 0 0 3.62935E-06 0 0
Q/P 31504 Fn3-117 97 rs777578106 0.9045 -0.042 0.991 N 0.493 0.234 0.27132560031 gnomAD-2.1.1 8.11E-06 None None None None N None 0 5.83E-05 None 0 0 None 0 None 0 0 0
Q/P 31504 Fn3-117 97 rs777578106 0.9045 -0.042 0.991 N 0.493 0.234 0.27132560031 gnomAD-4.0.0 3.208E-06 None None None None N None 0 4.59918E-05 None 0 0 None 0 0 0 0 0
R/Q 31606 Fn3-118 101 rs371840978 0.0929 -0.313 0.071 N 0.297 0.089 None gnomAD-2.1.1 1.22E-05 None None None None N None 1.2945E-04 0 None 0 0 None 0 None 0 9E-06 0
R/Q 31606 Fn3-118 101 rs371840978 0.0929 -0.313 0.071 N 0.297 0.089 None gnomAD-3.1.2 2.63E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 4.41E-05 0 0
R/Q 31606 Fn3-118 101 rs371840978 0.0929 -0.313 0.071 N 0.297 0.089 None gnomAD-4.0.0 1.42992E-05 None None None None N None 1.06935E-04 0 None 0 0 None 0 0 1.10576E-05 1.10047E-05 1.60705E-05
V/A 32006 Fn3-121 98 rs966964393 0.1108 -1.132 0.104 N 0.263 0.202 0.409665357357 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
V/A 32006 Fn3-121 98 rs966964393 0.1108 -1.132 0.104 N 0.263 0.202 0.409665357357 gnomAD-4.0.0 1.36941E-05 None None None None N None 0 0 None 0 0 None 0 0 1.80043E-05 0 0
V/M 32006 Fn3-121 98 rs191786700 0.0932 -0.427 0.09 N 0.228 0.055 None gnomAD-2.1.1 1.96795E-04 None None None None N None 9.92146E-04 4.24592E-04 None 0 0 None 0 None 0 1.17619E-04 1.41044E-04
V/M 32006 Fn3-121 98 rs191786700 0.0932 -0.427 0.09 N 0.228 0.055 None gnomAD-3.1.2 3.6139E-04 None None None None N None 9.89096E-04 2.61746E-04 0 0 0 None 0 9.49367E-03 1.02902E-04 0 0
V/M 32006 Fn3-121 98 rs191786700 0.0932 -0.427 0.09 N 0.228 0.055 None 1000 genomes 9.98403E-04 None None None None N None 3E-03 1.4E-03 None None 0 0 None None None 0 None
V/M 32006 Fn3-121 98 rs191786700 0.0932 -0.427 0.09 N 0.228 0.055 None gnomAD-4.0.0 2.00904E-04 None None None None N None 1.17311E-03 3.66642E-04 None 0 0 None 0 1.65289E-03 1.54393E-04 4.39271E-05 2.88258E-04
S/L 32200 Fn3-122 96 None 0.336 None 0.999 N 0.565 0.273 0.490631539035 gnomAD-4.0.0 4.10515E-06 None None None None N None 0 0 None 0 0 None 0 0 5.3967E-06 0 0
Q/E 32298 Fn3-123 97 rs201108270 0.1159 0.026 0.012 N 0.434 0.101 0.104622674875 gnomAD-2.1.1 4.2E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.22E-06 0
Q/E 32298 Fn3-123 97 rs201108270 0.1159 0.026 0.012 N 0.434 0.101 0.104622674875 gnomAD-4.0.0 4.19836E-06 None None None None N None 0 0 None 0 0 None 0 0 5.50717E-06 0 0
Q/H 32298 Fn3-123 97 rs776724759 0.2701 -0.628 None N 0.283 0.089 0.104622674875 gnomAD-2.1.1 4.2E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.23E-06 0
Q/H 32298 Fn3-123 97 rs776724759 0.2701 -0.628 None N 0.283 0.089 0.104622674875 gnomAD-4.0.0 1.65042E-06 None None None None N None 0 0 None 0 0 None 0 0 2.97511E-06 0 0
Q/R 32298 Fn3-123 97 None 0.1007 None None N 0.229 0.122 0.0846915920261 gnomAD-4.0.0 1.64912E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.48885E-05 0
R/C 32494 Fn3-124 96 rs727503539 0.1257 -0.893 0.999 N 0.551 0.354 0.690096916387 gnomAD-2.1.1 2.07E-05 None None None None N None 0 1.18036E-04 None 0 5.74E-05 None 0 None 0 0 0
R/C 32494 Fn3-124 96 rs727503539 0.1257 -0.893 0.999 N 0.551 0.354 0.690096916387 gnomAD-3.1.2 4.6E-05 None None None None N None 2.41E-05 3.93082E-04 0 0 0 None 0 0 0 0 0
R/C 32494 Fn3-124 96 rs727503539 0.1257 -0.893 0.999 N 0.551 0.354 0.690096916387 gnomAD-4.0.0 1.24445E-05 None None None None N None 1.33733E-05 2.51965E-04 None 0 0 None 0 0 0 2.21322E-05 3.21492E-05
R/H 32494 Fn3-124 96 rs371645048 0.0829 -1.716 0.996 N 0.515 0.258 None gnomAD-2.1.1 3.3E-05 None None None None N None 1.28227E-04 0 None 0 0 None 0 None 0 4.83E-05 0
R/H 32494 Fn3-124 96 rs371645048 0.0829 -1.716 0.996 N 0.515 0.258 None gnomAD-3.1.2 2.63E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 2.94E-05 0 0
R/H 32494 Fn3-124 96 rs371645048 0.0829 -1.716 0.996 N 0.515 0.258 None gnomAD-4.0.0 8.77626E-05 None None None None N None 5.35045E-05 0 None 0 0 None 0 8.26446E-04 1.0975E-04 0 4.82346E-05
M/I 32595 Fn3-125 97 None 0.3488 None 0.791 N 0.437 0.1 0.312001716656 gnomAD-4.0.0 1.92064E-06 None None None None N None 0 0 None 0 0 None 0 0 3.46955E-06 0 0
M/T 32595 Fn3-125 97 rs1360084595 0.0968 None 0.791 N 0.401 0.175 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
M/T 32595 Fn3-125 97 rs1360084595 0.0968 None 0.791 N 0.401 0.175 None gnomAD-4.0.0 6.57022E-06 None None None None N None 2.41255E-05 0 None 0 0 None 0 0 0 0 0
T/I 32696 Fn3-126 97 None 0.1713 None 0.875 N 0.456 0.224 0.36453787251 gnomAD-4.0.0 1.62592E-06 None None None None N None 0 0 None 0 2.78536E-05 None 0 0 0 0 0
K/E 32891 Fn3-127 97 rs768773826 0.5003 None 0.997 N 0.693 0.253 0.239901079897 gnomAD-4.0.0 3.19482E-06 None None None None N None 0 0 None 0 0 None 0 0 5.74841E-06 0 0
K/N 33387 Fn3-130 98 None 0.7434 None 0.974 N 0.662 0.311 0.181679512989 gnomAD-4.0.0 1.37387E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80554E-06 0 0
K/R 33488 Fn3-131 97 rs1415630189 0.0932 None 0.003 N 0.305 0.089 0.222439326576 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
K/R 33783 Fn3-132 95 None 0.0958 None 0.972 N 0.621 0.211 0.303123707472 gnomAD-4.0.0 1.59107E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85785E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.