Structural position:

  • Domain Type: Fn3
  • Aligned Position: 15
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand A

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
T/I 15669 Fn3-1 13 rs773039098 0.3008 -0.302 0.004 N 0.257 0.158 0.256283259241 gnomAD-2.1.1 8.09E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
T/I 15669 Fn3-1 13 rs773039098 0.3008 -0.302 0.004 N 0.257 0.158 0.256283259241 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
T/I 15669 Fn3-1 13 rs773039098 0.3008 -0.302 0.004 N 0.257 0.158 0.256283259241 gnomAD-4.0.0 2.60495E-05 None None None None N None 0 1.67118E-05 None 0 0 None 0 0 3.39242E-05 0 1.60328E-05
V/G 15770 Fn3-2 13 None 0.4673 None 0.908 D 0.823 0.524 0.824649001973 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/M 15770 Fn3-2 13 rs376192778 0.2378 -0.747 0.83 D 0.705 0.32 None gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/M 15770 Fn3-2 13 rs376192778 0.2378 -0.747 0.83 D 0.705 0.32 None gnomAD-4.0.0 6.5825E-06 None None None None N None 2.41476E-05 0 None 0 0 None 0 0 0 0 0
Q/E 15871 Fn3-3 13 rs1032020627 0.1105 None 0.992 N 0.317 0.343 0.290222751274 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.95465E-04 None 0 0 0 0 0
Q/E 15871 Fn3-3 13 rs1032020627 0.1105 None 0.992 N 0.317 0.343 0.290222751274 gnomAD-4.0.0 5.9033E-05 None None None None N None 0 0 None 0 1.08092E-03 None 0 0 0 0 2.90276E-05
Q/L 15871 Fn3-3 13 None 0.2116 None 0.997 N 0.605 0.384 0.522770035047 gnomAD-4.0.0 1.63837E-06 None None None None N None 0 0 None 0 0 None 0 0 2.89995E-06 0 0
Q/P 15871 Fn3-3 13 rs1327762563 0.1804 0.986 0.999 N 0.731 0.408 0.389596023526 gnomAD-2.1.1 4.37E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.43E-06 0
Q/P 15871 Fn3-3 13 rs1327762563 0.1804 0.986 0.999 N 0.731 0.408 0.389596023526 gnomAD-4.0.0 3.27673E-06 None None None None N None 0 0 None 0 0 None 0 0 5.79989E-06 0 0
I/K 16067 Fn3-4 13 None 0.3471 None 0.055 N 0.451 0.318 0.767110480819 gnomAD-4.0.0 1.36952E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79999E-06 0 0
I/R 16067 Fn3-4 13 rs2057385323 0.2983 None 0.295 N 0.445 0.353 0.794207813746 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/R 16067 Fn3-4 13 rs2057385323 0.2983 None 0.295 N 0.445 0.353 0.794207813746 gnomAD-4.0.0 6.58458E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47301E-05 0 0
I/T 16067 Fn3-4 13 rs2057385323 0.1998 None 0.012 N 0.365 0.203 0.587933254401 gnomAD-4.0.0 1.36952E-06 None None None None N None 0 0 None 3.83318E-05 0 None 0 0 8.99996E-07 0 0
I/V 16067 Fn3-4 13 rs1272100018 0.0609 None None N 0.095 0.068 0.231873229951 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 0 0
I/V 16067 Fn3-4 13 rs1272100018 0.0609 None None N 0.095 0.068 0.231873229951 gnomAD-4.0.0 1.59426E-06 None None None None N None 0 0 None 0 0 None 1.88331E-05 0 0 0 0
R/G 16167 Fn3-5 13 rs1312425985 0.5773 -1.315 0.653 N 0.259 0.2 0.348324211639 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
R/G 16167 Fn3-5 13 rs1312425985 0.5773 -1.315 0.653 N 0.259 0.2 0.348324211639 gnomAD-4.0.0 3.42388E-06 None None None None N None 0 0 None 0 0 None 0 0 4.50047E-06 0 0
R/Q 16167 Fn3-5 13 rs778774812 0.1837 -0.262 0.91 N 0.244 0.156 0.190952846119 gnomAD-2.1.1 1.21E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 1.78E-05 0
R/Q 16167 Fn3-5 13 rs778774812 0.1837 -0.262 0.91 N 0.244 0.156 0.190952846119 gnomAD-4.0.0 7.53244E-06 None None None None N None 0 0 None 0 0 None 0 0 9.00085E-06 1.16101E-05 0
V/A 16363 Fn3-6 13 rs369266863 0.7054 -1.659 0.334 N 0.401 0.281 None gnomAD-2.1.1 1.08E-05 None None None None N None 1.24378E-04 0 None 0 0 None 0 None 0 0 0
V/A 16363 Fn3-6 13 rs369266863 0.7054 -1.659 0.334 N 0.401 0.281 None gnomAD-3.1.2 2.63E-05 None None None None N None 7.25E-05 6.56E-05 0 0 0 None 0 0 0 0 0
V/A 16363 Fn3-6 13 rs369266863 0.7054 -1.659 0.334 N 0.401 0.281 None gnomAD-4.0.0 2.63397E-05 None None None None N None 7.24708E-05 6.56426E-05 None 0 0 None 0 0 0 0 0
V/I 16363 Fn3-6 13 rs776691941 0.0618 -0.559 0.001 N 0.111 0.119 0.393159880135 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.97E-06 0
V/I 16363 Fn3-6 13 rs776691941 0.0618 -0.559 0.001 N 0.111 0.119 0.393159880135 gnomAD-4.0.0 1.59333E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86172E-06 0 0
I/V 16462 Fn3-7 13 None 0.0811 None 0.02 N 0.178 0.118 0.222439326576 gnomAD-4.0.0 1.59975E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87181E-06 0 0
V/I 16563 Fn3-8 13 rs2056630981 0.0629 None 0.002 N 0.187 0.18 0.124217242631 gnomAD-4.0.0 1.59351E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.0303E-05
I/T 16663 Fn3-9 13 rs774556838 0.8041 -1.296 0.925 N 0.469 0.322 0.626729916089 gnomAD-2.1.1 1.23E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.76E-05 0
I/T 16663 Fn3-9 13 rs774556838 0.8041 -1.296 0.925 N 0.469 0.322 0.626729916089 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.95E-05 0 0
I/T 16663 Fn3-9 13 rs774556838 0.8041 -1.296 0.925 N 0.469 0.322 0.626729916089 gnomAD-4.0.0 1.61339E-05 None None None None N None 0 0 None 0 0 None 0 0 2.2052E-05 0 0
I/V 16663 Fn3-9 13 rs1410838349 0.1702 None 0.954 N 0.365 0.185 0.494031935134 gnomAD-4.0.0 3.42538E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49995E-06 0 0
V/M 16763 Fn3-10 13 rs927015538 0.3097 -0.876 1.0 D 0.695 0.41 0.666881549798 gnomAD-2.1.1 4.05E-06 None None None None N None 0 2.92E-05 None 0 0 None 0 None 0 0 0
V/M 16763 Fn3-10 13 rs927015538 0.3097 -0.876 1.0 D 0.695 0.41 0.666881549798 gnomAD-4.0.0 3.1909E-06 None None None None N None 0 4.58905E-05 None 0 0 None 0 0 0 0 0
I/V 17059 Fn3-12 13 rs188395969 0.064 -0.756 None N 0.091 0.087 None gnomAD-2.1.1 8.94E-05 None None None None N None 0 0 None 0 1.18961E-03 None 3.27E-05 None 0 0 1.40687E-04
I/V 17059 Fn3-12 13 rs188395969 0.064 -0.756 None N 0.091 0.087 None gnomAD-3.1.2 5.92E-05 None None None None N None 0 0 0 0 1.55461E-03 None 0 0 1.47E-05 0 0
I/V 17059 Fn3-12 13 rs188395969 0.064 -0.756 None N 0.091 0.087 None 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 2E-03 0 None None None 0 None
I/V 17059 Fn3-12 13 rs188395969 0.064 -0.756 None N 0.091 0.087 None gnomAD-4.0.0 2.60427E-05 None None None None N None 0 0 None 0 8.50378E-04 None 0 0 8.48067E-07 1.09847E-05 3.20441E-05
P/L 17159 Fn3-13 13 None 0.304 None 0.025 N 0.427 0.3 0.470318359215 gnomAD-4.0.0 3.1868E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72443E-06 0 0
P/T 17159 Fn3-13 13 None 0.2316 None 0.967 N 0.581 0.294 0.334161072951 gnomAD-4.0.0 1.59351E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86229E-06 0 0
I/M 17381 Fn3-14 13 rs2154197961 0.1399 None 0.004 N 0.213 0.201 0.170165803431 gnomAD-4.0.0 3.19387E-06 None None None None N None 0 0 None 0 2.78056E-05 None 0 0 0 0 3.03104E-05
I/T 17381 Fn3-14 13 rs775637498 0.2604 -1.604 0.117 D 0.341 0.316 0.578326236229 gnomAD-2.1.1 1.44E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.14E-05 0
I/T 17381 Fn3-14 13 rs775637498 0.2604 -1.604 0.117 D 0.341 0.316 0.578326236229 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
I/T 17381 Fn3-14 13 rs775637498 0.2604 -1.604 0.117 D 0.341 0.316 0.578326236229 gnomAD-4.0.0 7.4477E-06 None None None None N None 1.33711E-05 0 None 0 0 None 0 0 9.32861E-06 0 0
V/A 17482 Fn3-15 13 rs765605129 0.3024 -1.27 0.896 N 0.455 0.23 0.536381233585 gnomAD-2.1.1 4.2E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.32E-06 0
V/A 17482 Fn3-15 13 rs765605129 0.3024 -1.27 0.896 N 0.455 0.23 0.536381233585 gnomAD-4.0.0 6.87298E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.66406E-05
R/T 17874 Fn3-18 13 None 0.9758 None 0.998 N 0.616 0.417 0.510758216515 gnomAD-4.0.0 1.62079E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.46791E-05 0
I/T 18077 Fn3-19 13 rs1261779331 0.5577 -1.575 1.0 N 0.661 0.479 0.738040662849 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.63E-05 None 0 None 0 0 0
I/T 18077 Fn3-19 13 rs1261779331 0.5577 -1.575 1.0 N 0.661 0.479 0.738040662849 gnomAD-4.0.0 1.59431E-06 None None None None N None 0 0 None 0 2.78489E-05 None 0 0 0 0 0
I/V 18077 Fn3-19 13 None 0.0859 None 0.993 N 0.277 0.239 0.499535901811 gnomAD-4.0.0 2.73908E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69999E-06 0 1.65843E-05
R/C 18178 Fn3-20 13 rs554701601 0.16 -0.893 0.031 N 0.272 0.19 0.264081493735 gnomAD-2.1.1 2.51E-05 None None None None N None 0 2.84E-05 None 0 0 None 6.56E-05 None 0 3.14E-05 0
R/C 18178 Fn3-20 13 rs554701601 0.16 -0.893 0.031 N 0.272 0.19 0.264081493735 gnomAD-3.1.2 2.63E-05 None None None None N None 0 6.56E-05 0 0 0 None 0 0 2.94E-05 2.06782E-04 0
R/C 18178 Fn3-20 13 rs554701601 0.16 -0.893 0.031 N 0.272 0.19 0.264081493735 1000 genomes 3.99361E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 1E-03 None
R/C 18178 Fn3-20 13 rs554701601 0.16 -0.893 0.031 N 0.272 0.19 0.264081493735 gnomAD-4.0.0 2.48118E-05 None None None None N None 0 3.34024E-05 None 0 2.23684E-05 None 0 0 2.71435E-05 5.50031E-05 0
R/G 18178 Fn3-20 13 None 0.3275 None 0.82 N 0.435 0.205 0.347659731818 gnomAD-4.0.0 6.84881E-07 None None None None N None 0 0 None 0 0 None 1.87406E-05 0 0 0 0
R/H 18178 Fn3-20 13 rs879023208 0.1346 -1.74 0.031 N 0.185 0.146 None gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 1.0022E-04 0 None 0 None 0 0 0
R/H 18178 Fn3-20 13 rs879023208 0.1346 -1.74 0.031 N 0.185 0.146 None gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
R/H 18178 Fn3-20 13 rs879023208 0.1346 -1.74 0.031 N 0.185 0.146 None gnomAD-4.0.0 6.82426E-06 None None None None N None 1.3374E-05 0 None 3.3873E-05 0 None 0 0 7.63464E-06 0 0
I/T 18491 Fn3-22 13 None 0.536 None 0.896 N 0.405 0.374 0.648347046735 gnomAD-4.0.0 3.18764E-06 None None None None N None 0 0 None 0 0 None 0 0 5.7259E-06 0 0
I/V 18491 Fn3-22 13 None 0.0731 None 0.004 N 0.087 0.076 0.485493271093 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
I/V 18591 Fn3-23 13 rs890362775 0.0658 -1.318 None N 0.083 0.08 None gnomAD-2.1.1 9.81E-06 None None None None N None 0 0 None 0 0 None 0 None 0 2.07E-05 0
V/I 18797 Fn3-24 14 rs778722684 0.0577 -0.658 None N 0.177 0.074 0.112648838833 gnomAD-2.1.1 1.44E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.07E-05 0
V/I 18797 Fn3-24 14 rs778722684 0.0577 -0.658 None N 0.177 0.074 0.112648838833 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 18797 Fn3-24 14 rs778722684 0.0577 -0.658 None N 0.177 0.074 0.112648838833 gnomAD-4.0.0 1.09231E-05 None None None None N None 0 0 None 0 0 None 0 0 2.01584E-05 0 0
V/M 18896 Fn3-25 13 rs370629962 0.2824 -0.471 0.908 N 0.639 0.211 None gnomAD-2.1.1 1.0294E-04 None None None None N None 6.69E-05 3.19E-05 None 0 6.96298E-04 None 1.44886E-04 None 4.77E-05 3.76E-05 1.79211E-04
V/M 18896 Fn3-25 13 rs370629962 0.2824 -0.471 0.908 N 0.639 0.211 None gnomAD-3.1.2 3.29E-05 None None None None N None 4.83E-05 0 0 0 1.9478E-04 None 0 0 2.94E-05 0 0
V/M 18896 Fn3-25 13 rs370629962 0.2824 -0.471 0.908 N 0.639 0.211 None gnomAD-4.0.0 5.96478E-05 None None None None N None 1.21428E-04 1.74654E-05 None 3.45877E-05 3.84929E-04 None 0 0 3.67933E-05 6.82718E-05 2.92683E-04
L/V 19196 Fn3-27 14 rs397517630 0.1033 -1.204 0.999 N 0.508 0.211 None gnomAD-2.1.1 1.69654E-04 None None None None N None 8.5E-05 3.77731E-04 None 0 0 None 6.93E-05 None 0 2.179E-04 2.886E-04
L/V 19196 Fn3-27 14 rs397517630 0.1033 -1.204 0.999 N 0.508 0.211 None gnomAD-3.1.2 7.9E-05 None None None None N None 2.42E-05 1.96799E-04 0 0 0 None 0 6.32911E-03 7.35E-05 2.07125E-04 0
L/V 19196 Fn3-27 14 rs397517630 0.1033 -1.204 0.999 N 0.508 0.211 None gnomAD-4.0.0 1.39276E-04 None None None None N None 4.00363E-05 3.20189E-04 None 0 0 None 0 7.93913E-03 1.13804E-04 1.11542E-04 1.6056E-04
V/I 19296 Fn3-28 13 rs770490179 0.0662 -0.831 0.014 N 0.208 0.064 0.243972157842 gnomAD-2.1.1 8.09E-06 None None None None N None 0 0 None 0 0 None 3.29E-05 None 0 8.93E-06 0
V/I 19296 Fn3-28 13 rs770490179 0.0662 -0.831 0.014 N 0.208 0.064 0.243972157842 gnomAD-4.0.0 4.78903E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43906E-05 6.06171E-05
V/G 19492 Fn3-29 14 rs2050770436 0.6358 None 1.0 N 0.847 0.513 0.7700109816 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
V/G 19492 Fn3-29 14 rs2050770436 0.6358 None 1.0 N 0.847 0.513 0.7700109816 gnomAD-4.0.0 6.57938E-06 None None None None N None 2.41581E-05 0 None 0 0 None 0 0 0 0 0
V/L 19492 Fn3-29 14 rs1224533828 0.4656 -0.7 0.962 N 0.387 0.274 0.430126000877 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
V/L 19492 Fn3-29 14 rs1224533828 0.4656 -0.7 0.962 N 0.387 0.274 0.430126000877 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
V/L 19492 Fn3-29 14 rs1224533828 0.4656 -0.7 0.962 N 0.387 0.274 0.430126000877 gnomAD-4.0.0 6.5786E-06 None None None None N None 2.41558E-05 0 None 0 0 None 0 0 0 0 0
V/M 19492 Fn3-29 14 None 0.3069 None 0.999 N 0.709 0.382 0.502568190621 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 6.17284E-04 0 0 0
V/I 19591 Fn3-30 13 rs776808469 0.075 -0.545 0.014 N 0.205 0.074 0.261217442401 gnomAD-2.1.1 4.43E-05 None None None None N None 0 0 None 0 0 None 3.28839E-04 None 0 0 1.66223E-04
V/I 19591 Fn3-30 13 rs776808469 0.075 -0.545 0.014 N 0.205 0.074 0.261217442401 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
V/I 19591 Fn3-30 13 rs776808469 0.075 -0.545 0.014 N 0.205 0.074 0.261217442401 gnomAD-4.0.0 2.54215E-05 None None None None N None 0 0 None 0 0 None 0 0 0 4.40364E-04 1.6019E-05
T/A 19692 Fn3-31 13 rs771977738 0.1516 -0.593 0.425 N 0.285 0.16 0.17948927462 gnomAD-2.1.1 5.24E-05 None None None None N None 0 3.77665E-04 None 0 0 None 0 None 0 0 0
T/A 19692 Fn3-31 13 rs771977738 0.1516 -0.593 0.425 N 0.285 0.16 0.17948927462 gnomAD-4.0.0 1.09498E-05 None None None None N None 0 3.35706E-04 None 0 0 None 0 0 8.99588E-07 0 0
T/I 19692 Fn3-31 13 rs774404108 0.2529 None 0.642 N 0.345 0.175 0.240491677333 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 19692 Fn3-31 13 rs774404108 0.2529 None 0.642 N 0.345 0.175 0.240491677333 gnomAD-4.0.0 6.57687E-06 None None None None N None 2.41406E-05 0 None 0 0 None 0 0 0 0 0
T/K 19692 Fn3-31 13 None 0.2915 -0.533 0.001 N 0.165 0.188 0.227260227426 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
T/K 19692 Fn3-31 13 None 0.2915 -0.533 0.001 N 0.165 0.188 0.227260227426 gnomAD-4.0.0 2.05309E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79918E-06 0 1.65684E-05
T/R 19692 Fn3-31 13 rs774404108 0.28 -0.118 0.473 N 0.383 0.222 None gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.45E-05 0
T/R 19692 Fn3-31 13 rs774404108 0.28 -0.118 0.473 N 0.383 0.222 None gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
T/R 19692 Fn3-31 13 rs774404108 0.28 -0.118 0.473 N 0.383 0.222 None gnomAD-4.0.0 1.73562E-05 None None None None N None 0 0 None 0 0 None 0 0 2.28891E-05 0 1.60138E-05
V/A 19989 Fn3-33 13 rs778982581 0.279 -1.475 0.37 N 0.248 0.142 0.391000631824 gnomAD-2.1.1 1.79E-05 None None None None N None 0 0 None 0 1.0353E-04 None 3.27E-05 None 0 1.57E-05 0
V/A 19989 Fn3-33 13 rs778982581 0.279 -1.475 0.37 N 0.248 0.142 0.391000631824 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
V/A 19989 Fn3-33 13 rs778982581 0.279 -1.475 0.37 N 0.248 0.142 0.391000631824 gnomAD-4.0.0 1.36377E-05 None None None None N None 1.33508E-05 0 None 0 0 None 0 0 1.69554E-05 1.09813E-05 0
V/G 19989 Fn3-33 13 rs778982581 0.5166 None 0.987 N 0.718 0.407 0.666881549798 gnomAD-3.1.2 1.97E-05 None None None None N None 4.82E-05 6.56E-05 0 0 0 None 0 0 0 0 0
V/G 19989 Fn3-33 13 rs778982581 0.5166 None 0.987 N 0.718 0.407 0.666881549798 gnomAD-4.0.0 2.47957E-06 None None None None N None 2.67016E-05 1.66889E-05 None 0 0 None 0 0 8.47771E-07 0 0
V/I 19989 Fn3-33 13 rs1021499065 0.1029 None 0.973 N 0.481 0.262 0.427254322456 gnomAD-4.0.0 4.10647E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49808E-06 0 1.65717E-05
V/L 19989 Fn3-33 13 rs1021499065 0.577 None 0.948 D 0.449 0.304 0.504727117792 gnomAD-4.0.0 6.84412E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99616E-07 0 0
V/I 20184 Fn3-34 14 rs564621227 0.0717 -0.667 0.002 N 0.179 0.085 0.291694819147 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
V/I 20184 Fn3-34 14 rs564621227 0.0717 -0.667 0.002 N 0.179 0.085 0.291694819147 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
V/I 20184 Fn3-34 14 rs564621227 0.0717 -0.667 0.002 N 0.179 0.085 0.291694819147 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
V/I 20184 Fn3-34 14 rs564621227 0.0717 -0.667 0.002 N 0.179 0.085 0.291694819147 gnomAD-4.0.0 4.33883E-05 None None None None N None 0 0 None 0 0 None 0 0 5.68017E-05 0 4.80338E-05
I/V 20283 Fn3-35 13 rs1159161091 0.0699 None 0.248 N 0.141 0.074 0.337621943819 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 20283 Fn3-35 13 rs1159161091 0.0699 None 0.248 N 0.141 0.074 0.337621943819 gnomAD-4.0.0 4.96691E-06 None None None None N None 0 0 None 0 0 None 0 0 6.79472E-06 0 0
K/E 20383 Fn3-36 13 None 0.6631 None 0.986 N 0.445 0.189 0.435699915968 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
K/N 20383 Fn3-36 13 rs727504968 0.8063 -1.086 0.996 N 0.414 0.185 0.294918367191 gnomAD-2.1.1 8.09E-06 None None None None N None 1.29938E-04 0 None 0 0 None 0 None 0 0 0
K/N 20383 Fn3-36 13 rs727504968 0.8063 -1.086 0.996 N 0.414 0.185 0.294918367191 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/N 20383 Fn3-36 13 rs727504968 0.8063 -1.086 0.996 N 0.414 0.185 0.294918367191 gnomAD-4.0.0 3.10091E-06 None None None None N None 6.68145E-05 0 None 0 0 None 0 0 0 0 0
K/R 20383 Fn3-36 13 rs1168586982 0.0921 -0.307 0.959 N 0.44 0.144 0.335910606209 gnomAD-2.1.1 8.09E-06 None None None None N None 0 5.83E-05 None 0 0 None 0 None 0 0 0
K/R 20383 Fn3-36 13 rs1168586982 0.0921 -0.307 0.959 N 0.44 0.144 0.335910606209 gnomAD-4.0.0 4.78205E-06 None None None None N None 5.67859E-05 4.58379E-05 None 0 0 None 0 0 0 0 0
V/A 20581 Fn3-37 13 rs727504849 0.5119 -1.216 0.099 N 0.329 0.135 0.464784125046 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
V/A 20581 Fn3-37 13 rs727504849 0.5119 -1.216 0.099 N 0.329 0.135 0.464784125046 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
V/A 20581 Fn3-37 13 rs727504849 0.5119 -1.216 0.099 N 0.329 0.135 0.464784125046 gnomAD-4.0.0 2.47975E-06 None None None None N None 5.3416E-05 0 None 0 0 None 0 0 0 0 0
V/G 20581 Fn3-37 13 rs727504849 0.7456 None 0.967 N 0.619 0.446 0.868624395305 gnomAD-4.0.0 2.05339E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69899E-06 0 0
V/L 20581 Fn3-37 13 rs1559576334 0.6482 -0.621 0.369 N 0.373 0.168 0.343101102393 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
V/L 20581 Fn3-37 13 rs1559576334 0.6482 -0.621 0.369 N 0.373 0.168 0.343101102393 gnomAD-4.0.0 1.59266E-06 None None None None N None 5.66187E-05 0 None 0 0 None 0 0 0 0 0
V/A 20876 Fn3-39 13 None 0.3198 None 0.517 N 0.437 0.268 0.511331572721 gnomAD-4.0.0 6.85561E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15953E-05 0
V/G 20876 Fn3-39 13 None 0.4218 None 0.949 N 0.579 0.478 0.886552986545 gnomAD-4.0.0 6.85561E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15953E-05 0
V/M 20876 Fn3-39 13 rs774378099 0.1674 -0.617 0.901 N 0.495 0.302 0.463672176093 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
V/M 20876 Fn3-39 13 rs774378099 0.1674 -0.617 0.901 N 0.495 0.302 0.463672176093 gnomAD-4.0.0 1.59848E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02627E-05
V/A 20975 Fn3-40 13 rs758558735 0.4476 -1.565 0.992 N 0.474 0.34 0.542318960711 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
V/A 20975 Fn3-40 13 rs758558735 0.4476 -1.565 0.992 N 0.474 0.34 0.542318960711 gnomAD-4.0.0 1.59228E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85974E-06 0 0
V/E 20975 Fn3-40 13 rs758558735 0.6971 None 1.0 N 0.812 0.52 0.764146775576 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
V/E 20975 Fn3-40 13 rs758558735 0.6971 None 1.0 N 0.812 0.52 0.764146775576 gnomAD-4.0.0 1.59228E-06 None None None None N None 0 0 None 0 2.77979E-05 None 0 0 0 0 0
T/I 21076 Fn3-41 13 rs972090108 0.3476 -0.305 0.966 N 0.36 0.322 0.33110744837 gnomAD-2.1.1 7.33E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.6E-05 0
T/I 21076 Fn3-41 13 rs972090108 0.3476 -0.305 0.966 N 0.36 0.322 0.33110744837 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 21076 Fn3-41 13 rs972090108 0.3476 -0.305 0.966 N 0.36 0.322 0.33110744837 gnomAD-4.0.0 2.50761E-06 None None None None N None 0 0 None 0 0 None 0 0 2.57127E-06 0 1.6239E-05
T/R 21076 Fn3-41 13 rs972090108 0.3591 -0.406 0.934 N 0.351 0.331 0.544520820351 gnomAD-2.1.1 4.14E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.13E-06 0
T/R 21076 Fn3-41 13 rs972090108 0.3591 -0.406 0.934 N 0.351 0.331 0.544520820351 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/R 21076 Fn3-41 13 rs972090108 0.3591 -0.406 0.934 N 0.351 0.331 0.544520820351 gnomAD-4.0.0 1.25381E-06 None None None None N None 0 0 None 0 0 None 0 0 8.5709E-07 0 1.6239E-05
V/F 21278 Fn3-42 13 None 0.389 None 0.667 N 0.587 0.324 0.772501646899 gnomAD-4.0.0 2.05577E-06 None None None None N None 0 0 None 0 0 None 0 0 2.7009E-06 0 0
I/T 21572 Fn3-44 14 rs765749707 0.1013 -0.365 0.684 N 0.347 0.322 0.58940213094 gnomAD-2.1.1 1.79E-05 None None None None I None 1.24605E-04 0 None 0 0 None 0 None 0 1.57E-05 0
I/T 21572 Fn3-44 14 rs765749707 0.1013 -0.365 0.684 N 0.347 0.322 0.58940213094 gnomAD-3.1.2 2.63E-05 None None None None I None 7.24E-05 6.55E-05 0 0 0 None 0 0 0 0 0
I/T 21572 Fn3-44 14 rs765749707 0.1013 -0.365 0.684 N 0.347 0.322 0.58940213094 gnomAD-4.0.0 9.91821E-06 None None None None I None 6.67592E-05 3.335E-05 None 0 0 None 0 0 5.93455E-06 0 3.20287E-05
I/V 21572 Fn3-44 14 None 0.0678 None 0.012 N 0.115 0.081 0.258779203287 gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
V/I 21671 Fn3-45 13 rs764854284 0.0949 -0.688 0.543 N 0.214 0.202 0.309530620856 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 6.56E-05 None 0 8.9E-06 0
V/I 21671 Fn3-45 13 rs764854284 0.0949 -0.688 0.543 N 0.214 0.202 0.309530620856 gnomAD-4.0.0 1.27495E-05 None None None None N None 0 0 None 0 0 None 0 0 1.14512E-05 5.7374E-05 0
V/I 21769 Fn3-46 13 rs1426502571 0.08 -0.749 0.004 N 0.241 0.078 0.364926071151 gnomAD-2.1.1 4.35E-06 None None None None N None 0 0 None 0 5.93E-05 None 0 None 0 0 0
V/I 21769 Fn3-46 13 rs1426502571 0.08 -0.749 0.004 N 0.241 0.078 0.364926071151 gnomAD-4.0.0 1.64784E-06 None None None None N None 0 0 None 0 2.83094E-05 None 0 0 0 0 0
I/T 22067 Fn3-48 13 rs368042545 0.3296 -1.145 0.124 N 0.433 0.254 None gnomAD-2.1.1 8.11E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.8E-05 0
I/T 22067 Fn3-48 13 rs368042545 0.3296 -1.145 0.124 N 0.433 0.254 None gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/T 22067 Fn3-48 13 rs368042545 0.3296 -1.145 0.124 N 0.433 0.254 None gnomAD-4.0.0 1.55024E-05 None None None None N None 0 0 None 0 0 None 0 0 1.95002E-05 0 3.2039E-05
I/V 22067 Fn3-48 13 rs2154177929 0.0733 None None N 0.095 0.107 0.241078983079 gnomAD-4.0.0 1.59345E-06 None None None None N None 0 0 None 0 0 None 1.8953E-05 0 0 0 0
T/I 22168 Fn3-49 13 rs762765266 0.4735 0.397 0.994 N 0.519 0.333 0.345859378078 gnomAD-2.1.1 4.26E-06 None None None None N None 0 0 None 0 6.02E-05 None 0 None 0 0 0
T/K 22168 Fn3-49 13 None 0.5882 None 0.961 N 0.479 0.359 0.37281450598 gnomAD-4.0.0 2.06477E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70943E-06 0 0
V/L 22463 Fn3-51 13 rs1162620445 0.2333 -0.384 None N 0.063 0.099 0.0762999501168 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14705E-04 0 None 0 0 None 0 None 0 0 0
V/L 22463 Fn3-51 13 rs1162620445 0.2333 -0.384 None N 0.063 0.099 0.0762999501168 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/L 22463 Fn3-51 13 rs1162620445 0.2333 -0.384 None N 0.063 0.099 0.0762999501168 gnomAD-4.0.0 6.57566E-06 None None None None N None 2.41243E-05 0 None 0 0 None 0 0 0 0 0
V/D 22656 Fn3-52 14 rs758038684 0.8094 -2.029 0.999 N 0.727 0.548 0.811529650169 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
V/D 22656 Fn3-52 14 rs758038684 0.8094 -2.029 0.999 N 0.727 0.548 0.811529650169 gnomAD-4.0.0 1.09505E-05 None None None None N None 0 0 None 0 0 None 0 0 1.43942E-05 0 0
I/L 22853 Fn3-54 13 None 0.2376 None None N 0.051 0.147 0.435152311215 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 23052 Fn3-55 13 None 0.4655 None 0.987 N 0.496 0.374 0.639676494308 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
V/A 23151 Fn3-56 13 rs769864550 0.3467 -1.352 0.822 N 0.426 0.293 0.5343833383 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
V/I 23151 Fn3-56 13 rs1230729325 0.0731 -0.636 0.014 N 0.22 0.1 0.315609569513 gnomAD-2.1.1 8.07E-06 None None None None N None 0 5.82E-05 None 0 0 None 0 None 0 0 0
V/I 23151 Fn3-56 13 rs1230729325 0.0731 -0.636 0.014 N 0.22 0.1 0.315609569513 gnomAD-4.0.0 3.1851E-06 None None None None N None 0 4.57834E-05 None 0 0 None 0 0 0 0 0
T/I 23252 Fn3-57 13 None 0.3047 None 1.0 N 0.78 0.426 0.344251166708 gnomAD-4.0.0 7.10046E-07 None None None None N None 0 0 None 0 0 None 0 0 9.15186E-07 0 0
T/S 23252 Fn3-57 13 rs1710103271 0.2749 None 0.999 N 0.476 0.358 0.192905019026 gnomAD-4.0.0 7.10046E-07 None None None None N None 3.24781E-05 0 None 0 0 None 0 0 0 0 0
I/M 23447 Fn3-58 13 rs1213801020 0.1496 -0.694 0.942 N 0.517 0.402 0.43126412278 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/M 23447 Fn3-58 13 rs1213801020 0.1496 -0.694 0.942 N 0.517 0.402 0.43126412278 gnomAD-4.0.0 4.10714E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.7975E-05 1.65722E-05
I/V 23447 Fn3-58 13 None 0.0636 None 0.006 N 0.175 0.085 0.261217442401 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/L 23544 Fn3-59 13 None 0.2666 None 0.099 N 0.271 0.109 0.388495093706 gnomAD-4.0.0 6.84248E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99541E-07 0 0
I/V 23544 Fn3-59 13 rs1424128592 0.0768 -1.196 0.001 N 0.085 0.044 0.37762505005 gnomAD-2.1.1 7.15E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.57E-05 0
I/V 23544 Fn3-59 13 rs1424128592 0.0768 -1.196 0.001 N 0.085 0.044 0.37762505005 gnomAD-3.1.2 1.97E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 2.94E-05 0 0
I/V 23544 Fn3-59 13 rs1424128592 0.0768 -1.196 0.001 N 0.085 0.044 0.37762505005 gnomAD-4.0.0 4.95789E-06 None None None None N None 0 3.33344E-05 None 0 0 None 0 0 5.08617E-06 0 0
V/F 23739 Fn3-60 14 rs374485278 0.3127 -1.26 0.638 N 0.739 0.267 None gnomAD-2.1.1 4.06E-06 None None None None N None 6.49E-05 0 None 0 0 None 0 None 0 0 0
V/F 23739 Fn3-60 14 rs374485278 0.3127 -1.26 0.638 N 0.739 0.267 None gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/F 23739 Fn3-60 14 rs374485278 0.3127 -1.26 0.638 N 0.739 0.267 None gnomAD-4.0.0 3.04486E-06 None None None None N None 5.23158E-05 0 None 0 0 None 0 0 0 0 0
V/M 24135 Fn3-63 14 rs748407318 0.1508 -0.55 0.009 N 0.207 0.205 0.327419511103 gnomAD-2.1.1 9.88E-06 None None None None N None 0 0 None 0 6.12E-05 None 0 None 0 1.04E-05 0
V/M 24135 Fn3-63 14 rs748407318 0.1508 -0.55 0.009 N 0.207 0.205 0.327419511103 gnomAD-4.0.0 6.41099E-06 None None None None N None 0 0 None 0 2.55271E-05 None 0 0 6.4505E-06 0 1.72992E-05
I/T 24234 Fn3-64 13 rs939911271 0.38 -2.238 0.896 N 0.537 0.273 0.66819093994 gnomAD-2.1.1 5.71E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.17E-05 0
I/T 24234 Fn3-64 13 rs939911271 0.38 -2.238 0.896 N 0.537 0.273 0.66819093994 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 24234 Fn3-64 13 rs939911271 0.38 -2.238 0.896 N 0.537 0.273 0.66819093994 gnomAD-4.0.0 2.91717E-06 None None None None N None 0 0 None 0 0 None 0 0 5.33615E-06 0 0
I/V 24234 Fn3-64 13 rs746673481 0.0685 -1.337 0.046 N 0.138 0.106 0.488337271218 gnomAD-2.1.1 1.14E-05 None None None None N None 0 4.95E-05 None 0 0 None 0 None 0 1.17E-05 0
I/V 24234 Fn3-64 13 rs746673481 0.0685 -1.337 0.046 N 0.138 0.106 0.488337271218 gnomAD-4.0.0 3.75198E-06 None None None None N None 0 3.59712E-05 None 0 0 None 0 0 3.26203E-06 0 0
T/I 24335 Fn3-65 13 rs766442878 0.2875 0.001 0.997 N 0.787 0.26 0.368369118721 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/I 24335 Fn3-65 13 rs766442878 0.2875 0.001 0.997 N 0.787 0.26 0.368369118721 gnomAD-4.0.0 3.18448E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71961E-06 0 0
V/D 24531 Fn3-66 13 None 0.9063 None 0.688 D 0.701 0.469 0.858470133663 gnomAD-4.0.0 1.59203E-06 None None None None N None 0 0 None 0 2.77855E-05 None 0 0 0 0 0
V/F 24531 Fn3-66 13 None 0.4482 None 0.45 N 0.55 0.341 0.722108883045 gnomAD-4.0.0 2.05306E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69877E-06 0 0
V/A 24628 Fn3-67 13 rs1277357050 0.7415 -1.515 0.998 N 0.472 0.363 0.626300511109 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/A 24628 Fn3-67 13 rs1277357050 0.7415 -1.515 0.998 N 0.472 0.363 0.626300511109 gnomAD-4.0.0 1.59224E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43345E-05 0
V/A 24821 Fn3-68 14 rs1250205827 0.5318 None 0.999 N 0.52 0.431 0.656083742682 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/A 24821 Fn3-68 14 rs1250205827 0.5318 None 0.999 N 0.52 0.431 0.656083742682 gnomAD-4.0.0 6.57583E-06 None None None None N None 2.41301E-05 0 None 0 0 None 0 0 0 0 0
S/C 24920 Fn3-69 13 None 0.0575 None None N 0.227 0.075 0.252162846088 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
V/A 25018 Fn3-70 13 rs745832906 0.644 -1.342 0.999 N 0.514 0.268 None gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.35E-05 0
V/A 25018 Fn3-70 13 rs745832906 0.644 -1.342 0.999 N 0.514 0.268 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 25018 Fn3-70 13 rs745832906 0.644 -1.342 0.999 N 0.514 0.268 None gnomAD-4.0.0 2.85187E-05 None None None None N None 0 0 None 0 0 None 0 0 3.90064E-05 0 0
V/I 25018 Fn3-70 13 None 0.0764 None 0.997 N 0.475 0.231 0.462982567029 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 25217 Fn3-71 14 rs1292869028 0.0612 -0.503 0.014 N 0.187 0.057 0.257786959452 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.62E-05 None 0 None 0 0 0
V/I 25217 Fn3-71 14 rs1292869028 0.0612 -0.503 0.014 N 0.187 0.057 0.257786959452 gnomAD-4.0.0 1.59231E-06 None None None None N None 0 0 None 0 2.78396E-05 None 0 0 0 0 0
V/L 25316 Fn3-72 13 rs908851465 0.2391 None 0.437 N 0.307 0.137 0.493494165309 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/L 25316 Fn3-72 13 rs908851465 0.2391 None 0.437 N 0.307 0.137 0.493494165309 gnomAD-4.0.0 1.59188E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85925E-06 0 0
V/M 25316 Fn3-72 13 rs908851465 0.1646 None 0.968 N 0.436 0.363 0.586144602217 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/M 25316 Fn3-72 13 rs908851465 0.1646 None 0.968 N 0.436 0.363 0.586144602217 gnomAD-4.0.0 3.84475E-06 None None None None N None 5.07683E-05 0 None 0 0 None 0 0 0 0 0
I/L 25417 Fn3-73 13 None 0.1215 None 0.002 N 0.213 0.094 0.313818047136 gnomAD-4.0.0 6.84338E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99572E-07 0 0
I/V 25417 Fn3-73 13 rs755528335 0.0568 -1.225 None N 0.055 0.061 0.207176502487 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 0 None 1.85822E-04 0 0
I/V 25417 Fn3-73 13 rs755528335 0.0568 -1.225 None N 0.055 0.061 0.207176502487 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.42E-05 0 0 0 0
I/V 25417 Fn3-73 13 rs755528335 0.0568 -1.225 None N 0.055 0.061 0.207176502487 gnomAD-4.0.0 3.71896E-06 None None None None N None 0 0 None 0 0 None 9.37441E-05 0 0 0 0
I/N 25613 Fn3-74 13 rs1553601096 0.4205 None 0.949 N 0.67 0.532 0.860775079401 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
I/V 25613 Fn3-74 13 rs1707239042 0.0699 None 0.003 N 0.126 0.09 0.379366414296 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 25613 Fn3-74 13 rs1707239042 0.0699 None 0.003 N 0.126 0.09 0.379366414296 gnomAD-4.0.0 3.04496E-06 None None None None N None 0 0 None 0 0 None 0 0 3.61492E-06 0 0
V/I 25710 Fn3-75 13 rs1250369056 0.0869 -0.672 0.47 N 0.475 0.096 0.435043484731 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
V/I 25710 Fn3-75 13 rs1250369056 0.0869 -0.672 0.47 N 0.475 0.096 0.435043484731 gnomAD-3.1.2 2.63E-05 None None None None N None 0 2.62398E-04 0 0 0 None 0 0 0 0 0
V/I 25710 Fn3-75 13 rs1250369056 0.0869 -0.672 0.47 N 0.475 0.096 0.435043484731 gnomAD-4.0.0 3.7192E-06 None None None None N None 0 8.33834E-05 None 0 0 None 0 0 8.47772E-07 0 0
V/D 25903 Fn3-76 14 rs764027734 0.8465 -0.209 0.667 D 0.719 0.508 0.798081691357 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 8.9E-06 0
V/D 25903 Fn3-76 14 rs764027734 0.8465 -0.209 0.667 D 0.719 0.508 0.798081691357 gnomAD-4.0.0 1.27397E-05 None None None None N None 0 0 None 0 0 None 0 0 1.14391E-05 5.7323E-05 0
V/G 25903 Fn3-76 14 None 0.6394 None 0.667 N 0.699 0.502 0.769505205396 gnomAD-4.0.0 1.59247E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85977E-06 0 0
V/I 25903 Fn3-76 14 rs570615498 0.0602 -0.49 0.002 N 0.138 0.085 None gnomAD-2.1.1 1.46659E-04 None None None None N None 1.65426E-04 8.51E-05 None 0 5.17E-05 None 9.81E-05 None 1.20144E-04 2.11248E-04 0
V/I 25903 Fn3-76 14 rs570615498 0.0602 -0.49 0.002 N 0.138 0.085 None gnomAD-3.1.2 8.55E-05 None None None None N None 1.20802E-04 1.31216E-04 0 0 0 None 3.77216E-04 0 2.94E-05 0 0
V/I 25903 Fn3-76 14 rs570615498 0.0602 -0.49 0.002 N 0.138 0.085 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
V/I 25903 Fn3-76 14 rs570615498 0.0602 -0.49 0.002 N 0.138 0.085 None gnomAD-4.0.0 8.80262E-05 None None None None N None 9.33881E-05 1.00113E-04 None 3.37929E-05 0 None 7.81983E-05 0 9.57994E-05 7.68724E-05 4.8043E-05
V/L 25903 Fn3-76 14 None 0.2706 None 0.022 N 0.298 0.134 0.355242300401 gnomAD-4.0.0 1.36888E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79925E-06 0 0
I/M 26002 Fn3-77 13 None 0.1056 None 0.171 N 0.343 0.111 0.344945010812 gnomAD-4.0.0 2.05303E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69876E-06 0 0
V/D 26299 Fn3-79 14 rs73036377 0.8972 -0.436 1.0 D 0.833 0.608 None gnomAD-2.1.1 2.07238E-04 None None None None N None 2.1968E-03 8.62E-05 None 0 0 None 0 None 0 0 1.43926E-04
V/D 26299 Fn3-79 14 rs73036377 0.8972 -0.436 1.0 D 0.833 0.608 None gnomAD-3.1.2 6.25082E-04 None None None None N None 1.93227E-03 9.18153E-04 0 0 0 None 0 0 0 0 4.78469E-04
V/D 26299 Fn3-79 14 rs73036377 0.8972 -0.436 1.0 D 0.833 0.608 None 1000 genomes 1.19808E-03 None None None None N None 2.3E-03 4.3E-03 None None 0 0 None None None 0 None
V/D 26299 Fn3-79 14 rs73036377 0.8972 -0.436 1.0 D 0.833 0.608 None gnomAD-4.0.0 1.014E-04 None None None None N None 1.83454E-03 3.02989E-04 None 0 0 None 0 1.66279E-04 0 0 1.12652E-04
V/L 26299 Fn3-79 14 None 0.3125 None 0.997 N 0.507 0.305 0.505091552036 gnomAD-4.0.0 1.60738E-06 None None None None N None 0 0 None 0 0 None 0 2.44141E-04 0 0 0
I/T 26398 Fn3-80 13 rs749071678 0.2122 -1.494 0.892 N 0.586 0.363 0.615014731015 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
I/T 26398 Fn3-80 13 rs749071678 0.2122 -1.494 0.892 N 0.586 0.363 0.615014731015 gnomAD-4.0.0 6.84272E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15937E-05 0
T/A 26499 Fn3-81 13 rs780940162 0.1181 -0.788 0.996 N 0.453 0.256 0.207176502487 gnomAD-2.1.1 5.25E-05 None None None None N None 0 0 None 0 5.57E-05 None 3.92234E-04 None 0 0 0
T/A 26499 Fn3-81 13 rs780940162 0.1181 -0.788 0.996 N 0.453 0.256 0.207176502487 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93648E-04 None 0 0 0 0 0
T/A 26499 Fn3-81 13 rs780940162 0.1181 -0.788 0.996 N 0.453 0.256 0.207176502487 gnomAD-4.0.0 1.42619E-05 None None None None N None 0 0 None 0 2.22926E-05 None 0 0 0 2.30582E-04 1.60159E-05
T/N 26499 Fn3-81 13 rs1705978899 0.2824 None 1.0 N 0.667 0.421 0.405979908929 gnomAD-4.0.0 4.78133E-06 None None None None N None 0 0 None 0 5.5457E-05 None 0 0 2.85889E-06 0 0
V/L 26695 Fn3-82 13 rs772729384 0.238 -0.701 None N 0.212 0.116 0.215109475489 gnomAD-2.1.1 2.82E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.23E-05 0
V/L 26695 Fn3-82 13 rs772729384 0.238 -0.701 None N 0.212 0.116 0.215109475489 gnomAD-3.1.2 3.94E-05 None None None None N None 0 0 0 0 0 None 0 0 8.82E-05 0 0
V/L 26695 Fn3-82 13 rs772729384 0.238 -0.701 None N 0.212 0.116 0.215109475489 gnomAD-4.0.0 1.9833E-05 None None None None N None 0 0 None 0 0 None 0 0 2.71268E-05 0 0
V/G 26792 Fn3-83 13 None 0.7613 None 1.0 N 0.816 0.561 0.821814033924 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/M 26792 Fn3-83 13 rs1459115482 0.4346 -0.641 1.0 N 0.727 0.42 0.672247646848 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
V/M 26792 Fn3-83 13 rs1459115482 0.4346 -0.641 1.0 N 0.727 0.42 0.672247646848 gnomAD-4.0.0 3.18341E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71866E-06 0 0
V/F 26985 Fn3-84 14 None 0.4158 None 0.942 N 0.747 0.324 0.662129232514 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/F 27084 Fn3-85 13 rs371498697 0.1491 None 0.055 N 0.316 0.165 0.126345400529 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/F 27084 Fn3-85 13 rs371498697 0.1491 None 0.055 N 0.316 0.165 0.126345400529 gnomAD-4.0.0 1.24041E-06 None None None None N None 2.6733E-05 0 None 0 0 None 0 0 0 0 0
I/V 27084 Fn3-85 13 rs371498697 0.0534 -1.1 None N 0.069 0.13 None gnomAD-2.1.1 3.25E-05 None None None None N None 3.23666E-04 0 None 0 0 None 0 None 0 1.79E-05 1.67898E-04
I/V 27084 Fn3-85 13 rs371498697 0.0534 -1.1 None N 0.069 0.13 None gnomAD-3.1.2 5.92E-05 None None None None N None 1.92957E-04 6.55E-05 0 0 0 None 0 0 0 0 0
I/V 27084 Fn3-85 13 rs371498697 0.0534 -1.1 None N 0.069 0.13 None gnomAD-4.0.0 3.47314E-05 None None None None N None 2.00497E-04 1.67274E-05 None 0 0 None 0 0 3.30674E-05 0 1.60339E-05
I/F 27182 Fn3-86 13 rs879178329 0.522 -1.441 0.991 N 0.574 0.343 0.530160902827 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/F 27182 Fn3-86 13 rs879178329 0.522 -1.441 0.991 N 0.574 0.343 0.530160902827 gnomAD-4.0.0 6.84348E-07 None None None None N None 0 2.23784E-05 None 0 0 None 0 0 0 0 0
I/N 27182 Fn3-86 13 rs373448447 0.8012 -0.62 0.997 N 0.761 0.511 None gnomAD-2.1.1 3.22E-05 None None None None N None 3.72116E-04 0 None 0 0 None 0 None 0 0 0
I/N 27182 Fn3-86 13 rs373448447 0.8012 -0.62 0.997 N 0.761 0.511 None gnomAD-3.1.2 4.6E-05 None None None None N None 9.65E-05 1.30976E-04 0 0 0 None 0 0 0 0 4.78011E-04
I/N 27182 Fn3-86 13 rs373448447 0.8012 -0.62 0.997 N 0.761 0.511 None 1000 genomes 3.99361E-04 None None None None N None 1.5E-03 0 None None 0 0 None None None 0 None
I/N 27182 Fn3-86 13 rs373448447 0.8012 -0.62 0.997 N 0.761 0.511 None gnomAD-4.0.0 7.43719E-06 None None None None N None 1.19974E-04 3.33456E-05 None 0 0 None 0 0 0 0 1.60102E-05
I/V 27182 Fn3-86 13 rs879178329 0.0804 None 0.02 N 0.159 0.068 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/V 27182 Fn3-86 13 rs879178329 0.0804 None 0.02 N 0.159 0.068 None gnomAD-4.0.0 1.23962E-06 None None None None N None 1.33508E-05 0 None 0 0 None 0 0 8.47683E-07 0 0
I/F 27481 Fn3-88 13 rs780039092 0.3576 -1.557 0.998 N 0.574 0.368 0.6296786883 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
I/F 27481 Fn3-88 13 rs780039092 0.3576 -1.557 0.998 N 0.574 0.368 0.6296786883 gnomAD-3.1.2 3.29E-05 None None None None N None 1.20656E-04 0 0 0 0 None 0 0 0 0 0
I/F 27481 Fn3-88 13 rs780039092 0.3576 -1.557 0.998 N 0.574 0.368 0.6296786883 gnomAD-4.0.0 3.28692E-05 None None None None N None 1.20656E-04 0 None 0 0 None 0 0 0 0 0
I/V 27481 Fn3-88 13 rs780039092 0.0666 -1.113 0.333 N 0.159 0.104 0.448201132538 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
I/V 27481 Fn3-88 13 rs780039092 0.0666 -1.113 0.333 N 0.159 0.104 0.448201132538 gnomAD-4.0.0 1.59122E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85834E-06 0 0
T/A 27582 Fn3-89 13 rs1704394445 0.1116 None 0.001 N 0.074 0.098 0.211220785272 gnomAD-4.0.0 3.18313E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85861E-06 1.43271E-05 0
T/I 27582 Fn3-89 13 None 0.1442 None 0.655 N 0.465 0.148 0.362160248664 gnomAD-4.0.0 1.59157E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8586E-06 0 0
V/A 27778 Fn3-90 13 None 0.3233 None 0.873 N 0.437 0.398 0.561905760881 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
V/L 27778 Fn3-90 13 rs749009127 0.2578 -0.65 0.18 N 0.301 0.194 0.41859458845 gnomAD-2.1.1 1.79E-05 None None None None N None 0 0 None 0 2.07555E-04 None 0 None 0 0 1.41163E-04
V/L 27778 Fn3-90 13 rs749009127 0.2578 -0.65 0.18 N 0.301 0.194 0.41859458845 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 7.73994E-04 None 0 0 1.47E-05 0 0
V/L 27778 Fn3-90 13 rs749009127 0.2578 -0.65 0.18 N 0.301 0.194 0.41859458845 gnomAD-4.0.0 7.43888E-06 None None None None N None 0 0 None 0 1.56509E-04 None 0 0 3.391E-06 0 1.60241E-05
V/M 27778 Fn3-90 13 None 0.1666 None 0.97 N 0.631 0.425 0.558927764886 gnomAD-4.0.0 6.84458E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99625E-07 0 0
V/L 27875 Fn3-91 13 None 0.6451 None 0.867 N 0.4 0.218 0.44318313171 gnomAD-4.0.0 1.59558E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.03012E-05
A/T 28166 Fn3-93 13 rs1703694418 0.1064 None 0.958 N 0.632 0.255 0.301122078929 gnomAD-4.0.0 1.59815E-06 None None None None N None 0 0 None 0 2.78334E-05 None 0 0 0 0 0
A/V 28166 Fn3-93 13 rs1553564661 0.1382 None 0.142 N 0.315 0.302 0.260735089382 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/V 28166 Fn3-93 13 rs1553564661 0.1382 None 0.142 N 0.315 0.302 0.260735089382 gnomAD-4.0.0 3.85453E-06 None None None None N None 0 0 None 0 0 None 0 0 7.1978E-06 0 0
I/N 28264 Fn3-94 13 None 0.7303 None 0.967 N 0.675 0.491 0.820480598388 gnomAD-4.0.0 1.59116E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
L/F 28463 Fn3-95 14 None 0.1703 None 0.988 N 0.663 0.257 0.625243557465 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/R 28463 Fn3-95 14 None 0.2356 None 0.994 N 0.799 0.448 0.763205773721 gnomAD-4.0.0 1.59144E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85807E-06 0 0
V/M 28562 Fn3-96 13 None 0.2185 None 0.998 N 0.639 0.418 0.504604281553 gnomAD-4.0.0 1.59183E-06 None None None None N None 0 0 None 0 2.77824E-05 None 0 0 0 0 0
S/L 28663 Fn3-97 13 None 0.159 None 0.698 N 0.579 0.225 0.497214377195 gnomAD-4.0.0 1.59155E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85891E-06 0 0
S/T 28663 Fn3-97 13 None 0.0897 None 0.014 N 0.35 0.111 0.110078149338 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
V/I 28857 Fn3-98 13 rs780040559 0.065 -0.669 None N 0.197 0.081 0.384919354899 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
V/I 28857 Fn3-98 13 rs780040559 0.065 -0.669 None N 0.197 0.081 0.384919354899 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
V/I 28857 Fn3-98 13 rs780040559 0.065 -0.669 None N 0.197 0.081 0.384919354899 gnomAD-4.0.0 2.56203E-06 None None None None N None 0 3.38926E-05 None 0 0 None 0 0 0 0 0
I/T 28954 Fn3-99 13 None 0.1116 None None N 0.151 0.16 0.294206760003 gnomAD-4.0.0 4.77916E-06 None None None None N None 0 2.29347E-05 None 0 0 None 1.88509E-05 0 0 0 3.02608E-05
I/K 29150 Fn3-100 14 None 0.468 None 0.879 N 0.591 0.393 0.77209592603 gnomAD-4.0.0 6.84336E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99426E-07 0 0
I/L 29150 Fn3-100 14 rs189030321 0.1574 -0.823 0.084 N 0.199 0.075 0.227260227426 gnomAD-2.1.1 3.57E-05 None None None None I None 0 1.13148E-04 None 0 0 None 0 None 0 3.12E-05 2.80899E-04
I/L 29150 Fn3-100 14 rs189030321 0.1574 -0.823 0.084 N 0.199 0.075 0.227260227426 gnomAD-3.1.2 2.49652E-04 None None None None I None 2.41E-05 1.8984E-03 0 0 0 None 0 0 7.35E-05 0 1.43267E-03
I/L 29150 Fn3-100 14 rs189030321 0.1574 -0.823 0.084 N 0.199 0.075 0.227260227426 1000 genomes 3.99361E-04 None None None None I None 0 2.9E-03 None None 0 0 None None None 0 None
I/L 29150 Fn3-100 14 rs189030321 0.1574 -0.823 0.084 N 0.199 0.075 0.227260227426 gnomAD-4.0.0 4.52409E-05 None None None None I None 2.66446E-05 6.99767E-04 None 0 0 None 0 3.30033E-04 1.7799E-05 1.09786E-05 8.0023E-05
I/T 29150 Fn3-100 14 rs373106927 0.2067 -1.3 0.505 N 0.421 0.334 None gnomAD-2.1.1 8.57E-05 None None None None I None 0 1.97997E-04 None 1.06321E-03 5.12E-05 None 0 None 0 3.12E-05 1.40449E-04
I/T 29150 Fn3-100 14 rs373106927 0.2067 -1.3 0.505 N 0.421 0.334 None gnomAD-3.1.2 4.6E-05 None None None None I None 0 0 0 1.72811E-03 0 None 0 0 1.47E-05 0 0
I/T 29150 Fn3-100 14 rs373106927 0.2067 -1.3 0.505 N 0.421 0.334 None gnomAD-4.0.0 3.96659E-05 None None None None I None 0 1.33329E-04 None 1.3173E-03 0 None 0 0 8.47558E-06 1.09782E-05 9.60584E-05
I/V 29150 Fn3-100 14 rs189030321 0.0547 -1.047 None N 0.098 0.083 0.171388866994 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/V 29150 Fn3-100 14 rs189030321 0.0547 -1.047 None N 0.098 0.083 0.171388866994 gnomAD-4.0.0 6.84344E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
V/I 29249 Fn3-101 13 None 0.0978 None 0.656 N 0.473 0.188 0.387850303812 gnomAD-4.0.0 1.59113E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85778E-06 0 0
I/T 29347 Fn3-102 13 rs1200964659 0.2567 -1.344 0.989 N 0.531 0.401 0.606697734199 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 6.43501E-04 None 0 None 0 0 0
I/T 29347 Fn3-102 13 rs1200964659 0.2567 -1.344 0.989 N 0.531 0.401 0.606697734199 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92604E-04 None 0 0 0 0 0
I/T 29347 Fn3-102 13 rs1200964659 0.2567 -1.344 0.989 N 0.531 0.401 0.606697734199 gnomAD-4.0.0 2.47899E-06 None None None None N None 0 0 None 0 2.23324E-05 None 0 0 2.54284E-06 0 0
V/I 29546 Fn3-103 14 rs758393823 0.0716 -0.687 0.046 N 0.208 0.064 0.410204130746 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
V/I 29546 Fn3-103 14 rs758393823 0.0716 -0.687 0.046 N 0.208 0.064 0.410204130746 gnomAD-4.0.0 7.52593E-06 None None None None N None 0 0 None 0 5.03854E-05 None 0 0 6.29595E-06 1.15955E-05 1.65651E-05
I/F 29645 Fn3-104 13 rs746067385 0.2833 -1.63 0.81 D 0.375 0.204 0.411932830014 gnomAD-2.1.1 4.12E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.14E-06 0
I/F 29645 Fn3-104 13 rs746067385 0.2833 -1.63 0.81 D 0.375 0.204 0.411932830014 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/F 29645 Fn3-104 13 rs746067385 0.2833 -1.63 0.81 D 0.375 0.204 0.411932830014 gnomAD-4.0.0 6.83497E-06 None None None None N None 0 0 None 0 0 None 0 0 8.48719E-06 0 1.60601E-05
I/T 29645 Fn3-104 13 rs774597895 0.2606 -1.603 0.004 N 0.203 0.082 0.306377322295 gnomAD-2.1.1 1.65E-05 None None None None N None 0 1.18231E-04 None 0 0 None 0 None 0 0 0
I/T 29645 Fn3-104 13 rs774597895 0.2606 -1.603 0.004 N 0.203 0.082 0.306377322295 gnomAD-4.0.0 8.01218E-06 None None None None N None 0 1.16128E-04 None 0 0 None 0 0 0 0 0
S/L 29746 Fn3-105 13 rs1228690169 0.2239 None 0.477 N 0.543 0.183 0.489243007833 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.54E-05 0 0 0 None 0 0 0 0 0
S/L 29746 Fn3-105 13 rs1228690169 0.2239 None 0.477 N 0.543 0.183 0.489243007833 gnomAD-4.0.0 2.58321E-06 None None None None N None 0 1.70648E-05 None 0 0 None 0 0 2.41575E-06 0 0
V/L 29945 Fn3-106 13 rs1311015897 0.3572 None 0.898 D 0.368 0.243 0.641179492024 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
V/L 29945 Fn3-106 13 rs1311015897 0.3572 None 0.898 D 0.368 0.243 0.641179492024 gnomAD-4.0.0 1.24072E-05 None None None None N None 0 0 None 0 0 None 0 0 1.69647E-05 0 0
I/V 30237 Fn3-108 14 rs370272916 0.0885 -1.214 0.006 N 0.205 0.083 None gnomAD-2.1.1 1.61E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 2.67E-05 0
I/V 30237 Fn3-108 14 rs370272916 0.0885 -1.214 0.006 N 0.205 0.083 None gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 7.35E-05 0 0
I/V 30237 Fn3-108 14 rs370272916 0.0885 -1.214 0.006 N 0.205 0.083 None gnomAD-4.0.0 1.67325E-05 None None None None N None 0 1.66789E-05 None 0 0 None 0 0 2.11904E-05 0 1.60108E-05
V/A 30336 Fn3-109 13 None 0.407 None 0.645 D 0.423 0.324 0.585564602418 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 30434 Fn3-110 13 None 0.5782 None 0.822 N 0.437 0.281 0.574877809555 gnomAD-4.0.0 1.59268E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85972E-06 0 0
I/S 30632 Fn3-111 14 rs1698611582 0.5268 None 1.0 N 0.756 0.496 0.763475692304 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/S 30632 Fn3-111 14 rs1698611582 0.5268 None 1.0 N 0.756 0.496 0.763475692304 gnomAD-4.0.0 6.57315E-06 None None None None N None 2.41336E-05 0 None 0 0 None 0 0 0 0 0
I/L 30731 Fn3-112 13 rs16866391 0.1522 -0.877 0.005 N 0.216 0.104 0.0666544352282 gnomAD-2.1.1 1.62E-05 None None None None N None 0 0 None 0 0 None 3.28E-05 None 4.67E-05 1.79E-05 0
I/L 30731 Fn3-112 13 rs16866391 0.1522 -0.877 0.005 N 0.216 0.104 0.0666544352282 gnomAD-4.0.0 3.49651E-05 None None None None N None 0 0 None 0 0 None 1.87589E-05 0 4.14604E-05 2.32002E-05 3.32071E-05
I/V 30731 Fn3-112 13 rs16866391 0.054 -1.139 None N 0.097 0.062 None gnomAD-2.1.1 3.52571E-02 None None None None N None 3.26635E-03 2.23203E-01 None 7.77303E-04 6.58827E-02 None 4.4868E-03 None 2.25044E-03 1.72186E-03 2.64124E-02
I/V 30731 Fn3-112 13 rs16866391 0.054 -1.139 None N 0.097 0.062 None gnomAD-3.1.2 1.55402E-02 None None None None N None 2.94274E-03 1.10151E-01 0 1.44092E-03 7.14836E-02 None 1.88359E-03 3.16456E-03 1.4699E-03 5.7995E-03 1.72084E-02
I/V 30731 Fn3-112 13 rs16866391 0.054 -1.139 None N 0.097 0.062 None 1000 genomes 3.47444E-02 None None None None N None 8E-04 1.614E-01 None None 5.65E-02 0 None None None 4.1E-03 None
I/V 30731 Fn3-112 13 rs16866391 0.054 -1.139 None N 0.097 0.062 None gnomAD-4.0.0 1.09846E-02 None None None None N None 2.69686E-03 1.84631E-01 None 1.15051E-03 8.48172E-02 None 2.15875E-03 1.81999E-03 1.16092E-03 4.98737E-03 1.02018E-02
T/I 30833 Fn3-113 13 rs727505334 0.2907 0.033 0.994 N 0.511 0.37 0.328222422547 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
T/I 30833 Fn3-113 13 rs727505334 0.2907 0.033 0.994 N 0.511 0.37 0.328222422547 gnomAD-4.0.0 1.59115E-06 None None None None N None 0 0 None 0 2.77346E-05 None 0 0 0 0 0
V/M 31028 Fn3-114 13 None 0.2622 None 0.999 N 0.599 0.446 0.650362002609 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/S 31125 Fn3-115 13 None 0.238 None 0.999 N 0.471 0.361 0.299770980665 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
V/F 31321 Fn3-116 14 None 0.3493 None 0.638 N 0.653 0.255 0.727734521826 gnomAD-4.0.0 6.84169E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99431E-07 0 0
V/I 31321 Fn3-116 14 rs794729535 0.0626 -0.6 0.001 N 0.165 0.182 0.283371740733 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
V/I 31321 Fn3-116 14 rs794729535 0.0626 -0.6 0.001 N 0.165 0.182 0.283371740733 gnomAD-4.0.0 1.36834E-06 None None None None N None 0 2.23634E-05 None 0 0 None 0 0 8.99433E-07 0 0
V/L 31321 Fn3-116 14 None 0.2655 None 0.034 N 0.292 0.183 0.307966526162 gnomAD-4.0.0 6.84169E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99431E-07 0 0
V/M 31420 Fn3-117 13 rs1697609809 0.2496 None 0.83 N 0.7 0.315 0.627153701111 gnomAD-4.0.0 6.84396E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99719E-07 0 0
V/A 31518 Fn3-118 13 rs377016580 0.6443 -1.302 0.994 D 0.465 0.332 None gnomAD-2.1.1 1.45407E-04 None None None None N None 4.15E-05 2.89E-05 None 0 0 None 0 None 0 3.01839E-04 0
V/A 31518 Fn3-118 13 rs377016580 0.6443 -1.302 0.994 D 0.465 0.332 None gnomAD-3.1.2 2.30024E-04 None None None None N None 7.24E-05 0 0 0 0 None 0 0 4.70478E-04 0 0
V/A 31518 Fn3-118 13 rs377016580 0.6443 -1.302 0.994 D 0.465 0.332 None gnomAD-4.0.0 3.16664E-04 None None None None N None 8.0429E-05 1.68634E-05 None 0 0 None 3.15766E-05 0 4.10387E-04 0 2.7627E-04
V/I 31518 Fn3-118 13 rs1697407245 0.0766 None 0.543 N 0.297 0.159 0.454518106513 gnomAD-4.0.0 1.38687E-06 None None None None N None 0 0 None 0 0 None 0 0 9.09966E-07 1.19195E-05 0
V/L 31518 Fn3-118 13 None 0.6619 None 0.948 N 0.331 0.247 0.560190409015 gnomAD-4.0.0 6.93437E-07 None None None None N None 0 0 None 0 0 None 0 0 9.09966E-07 0 0
V/A 31720 Fn3-119 13 None 0.5476 None 0.334 N 0.487 0.386 0.596957824077 gnomAD-4.0.0 1.59454E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.0281E-05
V/E 31720 Fn3-119 13 rs1696965426 0.7342 None 0.781 N 0.646 0.575 0.674931257369 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/E 31720 Fn3-119 13 rs1696965426 0.7342 None 0.781 N 0.646 0.575 0.674931257369 gnomAD-4.0.0 6.57428E-06 None None None None N None 2.41441E-05 0 None 0 0 None 0 0 0 0 0
V/I 31720 Fn3-119 13 rs1575443877 0.0713 None 0.002 N 0.213 0.072 0.270447802918 gnomAD-4.0.0 1.59457E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02737E-05
T/P 31819 Fn3-120 13 None 0.1675 None 0.033 N 0.444 0.085 0.212008924253 gnomAD-4.0.0 1.59158E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85923E-06 0 0
V/G 32214 Fn3-123 13 None 0.4545 None 0.993 D 0.67 0.465 0.792547075834 gnomAD-4.0.0 1.59113E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85804E-06 0 0
V/I 32214 Fn3-123 13 rs1486085185 0.089 -0.786 0.449 N 0.495 0.123 0.37762505005 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
V/I 32214 Fn3-123 13 rs1486085185 0.089 -0.786 0.449 N 0.495 0.123 0.37762505005 gnomAD-4.0.0 6.84185E-06 None None None None N None 0 0 None 0 2.51978E-04 None 0 0 0 0 0
I/T 32412 Fn3-124 14 rs761246419 0.1008 -1.264 0.684 N 0.361 0.267 0.605904737968 gnomAD-2.1.1 1.21E-05 None None None None N None 0 5.81E-05 None 0 0 None 0 None 0 8.95E-06 0
I/T 32412 Fn3-124 14 rs761246419 0.1008 -1.264 0.684 N 0.361 0.267 0.605904737968 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 6.54E-05 0 0 0 None 0 0 0 0 0
I/T 32412 Fn3-124 14 rs761246419 0.1008 -1.264 0.684 N 0.361 0.267 0.605904737968 gnomAD-4.0.0 1.30348E-05 None None None None N None 1.33572E-05 1.00063E-04 None 0 0 None 0 0 1.18885E-05 0 0
V/I 32511 Fn3-125 13 rs752264462 0.0778 -0.698 0.014 N 0.169 0.087 0.218112801441 gnomAD-2.1.1 8.13E-06 None None None None N None 0 2.92E-05 None 0 5.64E-05 None 0 None 0 0 0
V/I 32511 Fn3-125 13 rs752264462 0.0778 -0.698 0.014 N 0.169 0.087 0.218112801441 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 32511 Fn3-125 13 rs752264462 0.0778 -0.698 0.014 N 0.169 0.087 0.218112801441 gnomAD-4.0.0 3.10153E-06 None None None None N None 0 3.3399E-05 None 0 2.23404E-05 None 0 0 1.69639E-06 0 0
T/A 32612 Fn3-126 13 rs1391570506 0.1723 None 0.543 N 0.211 0.139 0.202086224978 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/A 32612 Fn3-126 13 rs1391570506 0.1723 None 0.543 N 0.211 0.139 0.202086224978 gnomAD-4.0.0 2.02984E-06 None None None None N None 0 0 None 0 0 None 0 0 2.40989E-06 0 0
T/R 32612 Fn3-126 13 None 0.446 None 0.998 N 0.601 0.391 0.690083970411 gnomAD-4.0.0 1.20034E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
I/S 32808 Fn3-127 14 None 0.6218 None 1.0 N 0.761 0.454 0.772125089601 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/T 32808 Fn3-127 14 rs1388284089 0.4337 -1.588 1.0 N 0.678 0.477 0.681610798959 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
V/A 32909 Fn3-128 14 rs368877793 0.5792 -1.162 0.939 N 0.425 0.305 None gnomAD-2.1.1 1.46317E-04 None None None None N None 0 1.98121E-04 None 0 0 None 0 None 0 2.41938E-04 4.21112E-04
V/A 32909 Fn3-128 14 rs368877793 0.5792 -1.162 0.939 N 0.425 0.305 None gnomAD-3.1.2 2.03658E-04 None None None None N None 4.82E-05 3.27225E-04 0 0 0 None 9.41E-05 0 3.38086E-04 0 0
V/A 32909 Fn3-128 14 rs368877793 0.5792 -1.162 0.939 N 0.425 0.305 None gnomAD-4.0.0 2.69567E-04 None None None None N None 4.00363E-05 2.33357E-04 None 0 0 None 1.56206E-05 0 3.42442E-04 0 2.0818E-04
V/I 32909 Fn3-128 14 rs1161873728 0.0762 -0.592 0.046 N 0.226 0.111 0.309530620856 gnomAD-2.1.1 3.18E-05 None None None None N None 0 1.17924E-03 None 0 0 None 0 None 0 0 0
V/I 32909 Fn3-128 14 rs1161873728 0.0762 -0.592 0.046 N 0.226 0.111 0.309530620856 gnomAD-4.0.0 3.18283E-06 None None None None N None 0 2.28676E-05 None 0 2.77331E-05 None 0 0 0 0 0
I/T 33010 Fn3-129 13 None 0.2221 None 0.324 N 0.379 0.308 0.587297536726 gnomAD-4.0.0 1.59692E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86854E-06 0 0
I/V 33010 Fn3-129 13 rs1419804652 0.0657 None None N 0.083 0.052 0.28058544554 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 33010 Fn3-129 13 rs1419804652 0.0657 None None N 0.083 0.052 0.28058544554 gnomAD-4.0.0 2.02987E-06 None None None None I None 0 0 None 0 0 None 0 0 1.20493E-06 4.69616E-05 0
L/V 33303 Fn3-130 14 rs746345868 0.1245 -0.776 0.026 N 0.243 0.106 0.248417906384 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.67112E-04
V/I 33404 Fn3-131 13 None 0.079 None None N 0.119 0.144 0.0884992946249 gnomAD-4.0.0 2.92403E-06 None None None None N None 0 0 None 0 0 None 0 0 3.73653E-06 0 0
V/I 33701 Fn3-132 13 rs754435284 0.0721 -0.58 None N 0.143 0.083 0.305410167561 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/I 33701 Fn3-132 13 rs754435284 0.0721 -0.58 None N 0.143 0.083 0.305410167561 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/I 33701 Fn3-132 13 rs754435284 0.0721 -0.58 None N 0.143 0.083 0.305410167561 gnomAD-4.0.0 3.84281E-06 None None None None N None 1.69102E-05 0 None 0 0 None 0 0 0 2.67989E-05 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.