Structural position:

  • Domain Type: Fn3
  • Aligned Position: 26
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
P/A 15781 Fn3-2 24 rs932333848 0.0717 None 0.026 N 0.355 0.243 0.255270683199 gnomAD-4.0.0 8.21618E-06 None None None None N None 0 0 None 0 3.03674E-04 None 0 0 0 0 0
P/Q 15781 Fn3-2 24 rs756745318 0.1259 -1.811 0.968 D 0.662 0.386 0.448794319169 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
P/Q 15781 Fn3-2 24 rs756745318 0.1259 -1.811 0.968 D 0.662 0.386 0.448794319169 gnomAD-4.0.0 1.59381E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8627E-06 0 0
P/T 15781 Fn3-2 24 rs932333848 0.1291 None 0.896 D 0.579 0.376 0.450152462452 gnomAD-4.0.0 6.84682E-07 None None None None N None 0 0 None 0 2.53062E-05 None 0 0 0 0 0
P/L 15882 Fn3-3 24 rs1425908913 0.0958 -0.576 0.978 D 0.643 0.497 0.546478894215 gnomAD-2.1.1 4.36E-06 None None None None I None 0 0 None 0 0 None 3.84E-05 None 0 0 0
P/L 15882 Fn3-3 24 rs1425908913 0.0958 -0.576 0.978 D 0.643 0.497 0.546478894215 gnomAD-4.0.0 3.26721E-06 None None None None I None 0 0 None 0 0 None 0 0 2.89756E-06 1.52816E-05 0
P/S 15882 Fn3-3 24 rs1165988992 0.1333 -2.389 0.956 N 0.478 0.366 0.344251166708 gnomAD-2.1.1 4.36E-06 None None None None I None 0 0 None 0 0 None 3.83E-05 None 0 0 0
P/S 15882 Fn3-3 24 rs1165988992 0.1333 -2.389 0.956 N 0.478 0.366 0.344251166708 gnomAD-3.1.2 6.59E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/S 15882 Fn3-3 24 rs1165988992 0.1333 -2.389 0.956 N 0.478 0.366 0.344251166708 gnomAD-4.0.0 3.13029E-06 None None None None I None 0 0 None 0 0 None 0 0 3.40435E-06 1.15266E-05 0
P/T 15882 Fn3-3 24 rs1165988992 0.0967 None 0.198 N 0.323 0.217 0.28297238246 gnomAD-4.0.0 6.91826E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.67527E-05
P/S 16374 Fn3-6 24 None 0.2854 None 1.0 D 0.864 0.462 0.452737964553 gnomAD-4.0.0 1.59331E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43328E-05 0
E/K 16473 Fn3-7 24 rs1422077520 0.1983 0.314 0.999 N 0.599 0.459 0.37262878642 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
E/K 16473 Fn3-7 24 rs1422077520 0.1983 0.314 0.999 N 0.599 0.459 0.37262878642 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 16473 Fn3-7 24 rs1422077520 0.1983 0.314 0.999 N 0.599 0.459 0.37262878642 gnomAD-4.0.0 2.56785E-06 None None None None N None 0 1.69918E-05 None 0 0 None 0 0 2.39796E-06 0 0
K/N 16574 Fn3-8 24 None 0.8314 None 1.0 N 0.718 0.286 0.134241683229 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 16674 Fn3-9 24 rs2056518372 0.0845 None 0.454 N 0.457 0.141 0.37568098594 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 16674 Fn3-9 24 rs2056518372 0.0845 None 0.454 N 0.457 0.141 0.37568098594 gnomAD-4.0.0 5.58331E-06 None None None None N None 0 0 None 0 0 None 0 0 7.63272E-06 0 0
P/A 16774 Fn3-10 24 None 0.0748 None 0.005 N 0.251 0.232 0.236278675362 gnomAD-4.0.0 6.851E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00153E-07 0 0
P/Q 16774 Fn3-10 24 None 0.2574 None 0.934 N 0.568 0.33 0.391930172978 gnomAD-4.0.0 4.11045E-06 None None None None N None 0 0 None 0 0 None 0 0 5.4008E-06 0 0
P/A 16875 Fn3-11 24 None 0.0938 None 0.619 N 0.371 0.235 0.218112801441 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/L 16875 Fn3-11 24 rs776726020 0.1923 -0.6 0.998 D 0.828 0.452 0.75522204045 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
P/L 16875 Fn3-11 24 rs776726020 0.1923 -0.6 0.998 D 0.828 0.452 0.75522204045 gnomAD-4.0.0 1.5929E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43328E-05 0
P/A 17070 Fn3-12 24 None 0.087 None 0.996 N 0.666 0.396 0.36076525451 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/T 17392 Fn3-14 24 None 0.3103 None 1.0 N 0.873 0.603 0.445107144611 gnomAD-4.0.0 1.36961E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.31922E-05 0
E/G 17493 Fn3-15 24 rs2055442864 0.3219 None 0.998 N 0.685 0.356 0.425615883737 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
E/G 17493 Fn3-15 24 rs2055442864 0.3219 None 0.998 N 0.685 0.356 0.425615883737 gnomAD-4.0.0 6.57843E-06 None None None None N None 0 6.55566E-05 None 0 0 None 0 0 0 0 0
E/Q 17493 Fn3-15 24 rs1046078803 0.1526 -0.534 0.998 N 0.567 0.223 0.250579442822 gnomAD-2.1.1 4.14E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.18E-06 0
E/Q 17493 Fn3-15 24 rs1046078803 0.1526 -0.534 0.998 N 0.567 0.223 0.250579442822 gnomAD-4.0.0 8.00538E-06 None None None None N None 0 0 None 0 0 None 0 0 1.14943E-05 0 3.03841E-05
P/A 17592 Fn3-16 24 rs541127460 0.0896 None 0.767 N 0.419 0.301 0.236890367714 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 2.88351E-04 0 None 0 0 0 0 0
P/A 17592 Fn3-16 24 rs541127460 0.0896 None 0.767 N 0.419 0.301 0.236890367714 gnomAD-4.0.0 6.57912E-06 None None None None N None 0 0 None 2.88351E-04 0 None 0 0 0 0 0
P/H 17592 Fn3-16 24 None 0.3815 None 1.0 N 0.821 0.483 0.691146523942 gnomAD-4.0.0 6.84579E-07 None None None None N None 0 0 None 0 2.53331E-05 None 0 0 0 0 0
P/L 17592 Fn3-16 24 rs1559744241 0.1496 None 0.999 N 0.795 0.442 0.807022764505 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
P/L 17592 Fn3-16 24 rs1559744241 0.1496 None 0.999 N 0.795 0.442 0.807022764505 gnomAD-4.0.0 1.36916E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79954E-06 0 0
P/S 17592 Fn3-16 24 None 0.2211 None 0.998 N 0.768 0.377 0.366848117066 gnomAD-4.0.0 6.84586E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65821E-05
P/T 17592 Fn3-16 24 rs541127460 0.1717 -1.59 0.999 N 0.782 0.39 0.531581166724 gnomAD-2.1.1 2.42E-05 None None None None N None 0 0 None 0 5.65E-05 None 1.63431E-04 None 0 0 0
P/T 17592 Fn3-16 24 rs541127460 0.1717 -1.59 0.999 N 0.782 0.39 0.531581166724 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
P/T 17592 Fn3-16 24 rs541127460 0.1717 -1.59 0.999 N 0.782 0.39 0.531581166724 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
P/T 17592 Fn3-16 24 rs541127460 0.1717 -1.59 0.999 N 0.782 0.39 0.531581166724 gnomAD-4.0.0 1.17804E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.97663E-04 1.60205E-05
E/Q 17885 Fn3-18 24 None 0.1913 None 0.301 N 0.449 0.069 0.17948927462 gnomAD-4.0.0 6.85348E-07 None None None None N None 2.99778E-05 0 None 0 0 None 0 0 0 0 0
A/D 18088 Fn3-19 24 None 0.2251 None 0.864 N 0.798 0.284 0.540835050783 gnomAD-4.0.0 1.59431E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86377E-06 0 0
A/T 18088 Fn3-19 24 rs781223649 0.0844 -1.44 0.013 D 0.315 0.128 0.168933306366 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
A/T 18088 Fn3-19 24 rs781223649 0.0844 -1.44 0.013 D 0.315 0.128 0.168933306366 gnomAD-4.0.0 1.59407E-06 None None None None N None 0 2.28927E-05 None 0 0 None 0 0 0 0 0
P/T 18189 Fn3-20 24 rs2054184050 0.2392 None 1.0 N 0.874 0.443 0.509168631294 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
P/T 18189 Fn3-20 24 rs2054184050 0.2392 None 1.0 N 0.874 0.443 0.509168631294 gnomAD-4.0.0 2.03023E-06 None None None None I None 0 6.15764E-05 None 0 0 None 0 0 0 0 3.40298E-05
P/S 18295 Fn3-21 24 rs1162176452 0.2272 -1.749 0.885 N 0.597 0.318 0.358540694251 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
P/S 18295 Fn3-21 24 rs1162176452 0.2272 -1.749 0.885 N 0.597 0.318 0.358540694251 gnomAD-3.1.2 1.32E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 1.47E-05 0 0
P/S 18295 Fn3-21 24 rs1162176452 0.2272 -1.749 0.885 N 0.597 0.318 0.358540694251 gnomAD-4.0.0 5.15904E-06 None None None None N None 1.69653E-05 1.71662E-05 None 0 0 None 0 0 4.8157E-06 0 0
M/I 18502 Fn3-22 24 rs747559618 0.39 None 0.002 N 0.295 0.065 0.378498632473 gnomAD-4.0.0 1.593E-06 None None None None N None 5.67151E-05 0 None 0 0 None 0 0 0 0 0
M/T 18502 Fn3-22 24 None 0.3658 None 0.012 N 0.33 0.167 0.444305618086 gnomAD-4.0.0 1.59296E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86156E-06 0 0
P/H 18602 Fn3-23 24 rs559554374 0.4661 -1.7 1.0 N 0.87 0.47 0.567170738818 gnomAD-2.1.1 8.41E-06 None None None None N None 0 0 None 0 1.13572E-04 None 0 None 0 0 0
P/H 18602 Fn3-23 24 rs559554374 0.4661 -1.7 1.0 N 0.87 0.47 0.567170738818 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.9478E-04 None 0 0 0 0 0
P/H 18602 Fn3-23 24 rs559554374 0.4661 -1.7 1.0 N 0.87 0.47 0.567170738818 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
P/H 18602 Fn3-23 24 rs559554374 0.4661 -1.7 1.0 N 0.87 0.47 0.567170738818 gnomAD-4.0.0 2.60146E-06 None None None None N None 0 0 None 0 4.88806E-05 None 0 0 0 0 0
P/S 18602 Fn3-23 24 rs781300931 0.3078 None 0.999 N 0.771 0.377 0.303781844768 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
P/S 18602 Fn3-23 24 rs781300931 0.3078 None 0.999 N 0.771 0.377 0.303781844768 gnomAD-4.0.0 5.61931E-06 None None None None N None 0 0 None 0 0 None 0 0 7.66836E-06 0 0
P/T 18602 Fn3-23 24 rs781300931 0.2666 -2.081 0.999 N 0.777 0.39 0.454893017966 gnomAD-2.1.1 8.42E-06 None None None None N None 0 0 None 0 5.68E-05 None 0 None 0 9.29E-06 0
P/T 18602 Fn3-23 24 rs781300931 0.2666 -2.081 0.999 N 0.777 0.39 0.454893017966 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
P/T 18602 Fn3-23 24 rs781300931 0.2666 -2.081 0.999 N 0.777 0.39 0.454893017966 gnomAD-4.0.0 1.8731E-06 None None None None N None 2.6881E-05 0 None 0 0 None 0 0 8.5204E-07 0 0
P/L 18808 Fn3-24 25 rs2052664825 0.1772 None 1.0 N 0.886 0.5 0.655917873618 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/L 18808 Fn3-24 25 rs2052664825 0.1772 None 1.0 N 0.886 0.5 0.655917873618 gnomAD-4.0.0 8.12491E-06 None None None None N None 0 0 None 0 0 None 0 0 1.02117E-05 0 1.61561E-05
P/S 18808 Fn3-24 25 rs139748528 0.2821 -2.184 1.0 N 0.857 0.457 None gnomAD-2.1.1 1.72E-05 None None None None N None 1.31874E-04 0 None 0 0 None 0 None 0 9.33E-06 1.78063E-04
P/S 18808 Fn3-24 25 rs139748528 0.2821 -2.184 1.0 N 0.857 0.457 None gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
P/S 18808 Fn3-24 25 rs139748528 0.2821 -2.184 1.0 N 0.857 0.457 None 1000 genomes 3.99361E-04 None None None None N None 1.5E-03 0 None None 0 0 None None None 0 None
P/S 18808 Fn3-24 25 rs139748528 0.2821 -2.184 1.0 N 0.857 0.457 None gnomAD-4.0.0 8.12465E-06 None None None None N None 1.34485E-04 0 None 0 0 None 0 0 1.70206E-06 0 1.61504E-05
E/D 18907 Fn3-25 24 rs1238984956 0.3866 -1.295 0.999 N 0.578 0.186 0.353336612579 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
E/D 18907 Fn3-25 24 rs1238984956 0.3866 -1.295 0.999 N 0.578 0.186 0.353336612579 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/D 18907 Fn3-25 24 rs1238984956 0.3866 -1.295 0.999 N 0.578 0.186 0.353336612579 gnomAD-4.0.0 6.57886E-06 None None None None I None 2.41418E-05 0 None 0 0 None 0 0 0 0 0
E/G 18907 Fn3-25 24 rs1184443568 0.4582 None 1.0 N 0.73 0.474 0.388010793773 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/G 18907 Fn3-25 24 rs1184443568 0.4582 None 1.0 N 0.73 0.474 0.388010793773 gnomAD-4.0.0 1.79982E-05 None None None None I None 0 0 None 0 0 None 0 0 2.46029E-05 0 0
E/K 18907 Fn3-25 24 None 0.398 None 0.999 N 0.644 0.466 0.330589388543 gnomAD-4.0.0 1.59715E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86669E-06 0 0
P/S 19011 Fn3-26 24 rs1436800817 0.191 -1.665 0.998 N 0.769 0.415 0.37479162749 gnomAD-2.1.1 1.59398E-04 None None None None N None 0 0 None 0 0 None 0 None 0 2.59336E-04 9.19118E-04
P/S 19011 Fn3-26 24 rs1436800817 0.191 -1.665 0.998 N 0.769 0.415 0.37479162749 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
P/S 19011 Fn3-26 24 rs1436800817 0.191 -1.665 0.998 N 0.769 0.415 0.37479162749 gnomAD-4.0.0 6.44629E-06 None None None None N None 0 0 None 0 0 None 0 0 1.19968E-05 0 0
S/C 19207 Fn3-27 25 rs2051384370 0.1 None 0.883 N 0.669 0.291 0.395745362164 gnomAD-4.0.0 1.60229E-06 None None None None I None 0 2.30979E-05 None 0 0 None 0 0 0 0 0
S/P 19207 Fn3-27 25 None 0.0831 None 0.667 N 0.659 0.221 0.190952846119 gnomAD-4.0.0 1.60208E-06 None None None None I None 0 0 None 0 0 None 0 0 2.87221E-06 0 0
P/R 19307 Fn3-28 24 None 0.5235 None 0.994 N 0.729 0.411 0.542587012665 gnomAD-4.0.0 1.20039E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31258E-06 0 0
P/A 19503 Fn3-29 25 rs762898731 0.1022 -1.684 1.0 N 0.823 0.385 0.364342057095 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
P/A 19503 Fn3-29 25 rs762898731 0.1022 -1.684 1.0 N 0.823 0.385 0.364342057095 gnomAD-4.0.0 1.59279E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85961E-06 0 0
P/L 19503 Fn3-29 25 rs2050765996 0.1621 None 1.0 N 0.885 0.496 0.717771820488 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/S 19503 Fn3-29 25 rs762898731 0.2291 -2.14 1.0 N 0.858 0.442 0.415438038341 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.65E-05 None 0 None 0 0 0
P/S 19503 Fn3-29 25 rs762898731 0.2291 -2.14 1.0 N 0.858 0.442 0.415438038341 gnomAD-4.0.0 1.59279E-06 None None None None N None 0 0 None 0 2.79049E-05 None 0 0 0 0 0
K/T 19602 Fn3-30 24 None 0.2127 None 0.117 N 0.474 0.148 0.228597637076 gnomAD-4.0.0 1.59228E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85969E-06 0 0
P/A 19703 Fn3-31 24 rs1033900652 0.093 -1.748 1.0 N 0.823 0.378 0.374434639691 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
P/A 19703 Fn3-31 24 rs1033900652 0.093 -1.748 1.0 N 0.823 0.378 0.374434639691 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
P/A 19703 Fn3-31 24 rs1033900652 0.093 -1.748 1.0 N 0.823 0.378 0.374434639691 gnomAD-4.0.0 6.19843E-06 None None None None N None 0 0 None 0 0 None 0 0 8.47726E-06 0 0
P/L 19703 Fn3-31 24 None 0.115 None 1.0 N 0.879 0.428 0.471539375507 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/D 19900 Fn3-32 24 rs1559600496 0.108 None 0.054 N 0.176 0.043 0.1749357433 gnomAD-2.1.1 4.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.04E-06 0
E/D 19900 Fn3-32 24 rs1559600496 0.108 None 0.054 N 0.176 0.043 0.1749357433 gnomAD-4.0.0 1.59508E-06 None None None None N None 0 0 None 0 0 None 0 2.41779E-04 0 0 0
E/G 19900 Fn3-32 24 rs2050365298 0.2692 None 0.978 N 0.593 0.416 0.361558571881 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 19900 Fn3-32 24 rs2050365298 0.2692 None 0.978 N 0.593 0.416 0.361558571881 gnomAD-4.0.0 2.56759E-06 None None None None N None 0 0 None 0 0 None 0 0 4.79375E-06 0 0
K/E 20394 Fn3-36 24 rs1488885188 0.7468 0.15 0.999 N 0.61 0.404 0.297718772494 gnomAD-2.1.1 4.04E-06 None None None None N None 6.53E-05 0 None 0 0 None 0 None 0 0 0
K/E 20394 Fn3-36 24 rs1488885188 0.7468 0.15 0.999 N 0.61 0.404 0.297718772494 gnomAD-4.0.0 2.0538E-06 None None None None N None 5.98408E-05 0 None 0 0 None 0 0 8.99798E-07 0 0
K/N 20394 Fn3-36 24 rs1251147363 0.9406 -0.274 1.0 N 0.745 0.388 0.304108284078 gnomAD-2.1.1 7.17E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.57E-05 0
K/N 20394 Fn3-36 24 rs1251147363 0.9406 -0.274 1.0 N 0.745 0.388 0.304108284078 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
K/N 20394 Fn3-36 24 rs1251147363 0.9406 -0.274 1.0 N 0.745 0.388 0.304108284078 gnomAD-4.0.0 6.201E-06 None None None None N None 1.33618E-05 0 None 0 0 None 0 0 7.63162E-06 0 0
N/I 20592 Fn3-37 24 rs2049855196 0.2856 None 0.669 N 0.549 0.229 0.452546404249 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/K 20592 Fn3-37 24 rs554308191 0.6429 -0.169 0.801 N 0.453 0.14 0.0666544352282 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
N/K 20592 Fn3-37 24 rs554308191 0.6429 -0.169 0.801 N 0.453 0.14 0.0666544352282 gnomAD-4.0.0 3.4223E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.79818E-05 0
R/S 20691 Fn3-38 24 None 0.8663 None 0.92 N 0.499 0.253 0.231873229951 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/L 20887 Fn3-39 24 None 0.0809 None 0.921 N 0.532 0.356 0.449088463789 gnomAD-4.0.0 1.6025E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85969E-06 0 0
K/R 21087 Fn3-41 24 rs1395427495 0.1068 -0.527 0.999 N 0.62 0.233 0.342631996419 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/R 21087 Fn3-41 24 rs1395427495 0.1068 -0.527 0.999 N 0.62 0.233 0.342631996419 gnomAD-4.0.0 6.57523E-06 None None None None I None 2.41196E-05 0 None 0 0 None 0 0 0 0 0
P/T 21389 Fn3-43 24 rs2049063426 0.3472 None 0.989 D 0.617 0.341 0.537402380065 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
P/T 21389 Fn3-43 24 rs2049063426 0.3472 None 0.989 D 0.617 0.341 0.537402380065 gnomAD-4.0.0 6.57756E-06 None None None None I None 2.41406E-05 0 None 0 0 None 0 0 0 0 0
R/K 21682 Fn3-45 24 None 0.0781 None 0.006 N 0.211 0.134 0.158396225186 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/T 21682 Fn3-45 24 rs1553632377 0.1909 None 0.822 N 0.63 0.263 0.285316908763 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 6.17284E-04 0 0 0
R/C 21780 Fn3-46 24 rs745681257 0.1795 -1.077 0.999 N 0.784 0.399 0.604945591675 gnomAD-2.1.1 1.47E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.24E-05 0
R/C 21780 Fn3-46 24 rs745681257 0.1795 -1.077 0.999 N 0.784 0.399 0.604945591675 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 21780 Fn3-46 24 rs745681257 0.1795 -1.077 0.999 N 0.784 0.399 0.604945591675 gnomAD-4.0.0 1.30546E-05 None None None None N None 0 0 None 0 0 None 0 0 1.69868E-05 1.11044E-05 0
R/H 21780 Fn3-46 24 rs779044914 0.1237 -1.842 1.0 N 0.572 0.309 0.299427821978 gnomAD-2.1.1 1.66E-05 None None None None N None 0 2.97E-05 None 0 5.77E-05 None 3.41E-05 None 0 9.24E-06 0
R/H 21780 Fn3-46 24 rs779044914 0.1237 -1.842 1.0 N 0.572 0.309 0.299427821978 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/H 21780 Fn3-46 24 rs779044914 0.1237 -1.842 1.0 N 0.572 0.309 0.299427821978 gnomAD-4.0.0 1.05671E-05 None None None None N None 1.33704E-05 3.36101E-05 None 0 2.24699E-05 None 0 0 6.79439E-06 5.55235E-05 0
P/A 21979 Fn3-47 24 rs1360266668 0.0923 -1.698 0.998 N 0.712 0.369 0.293147016451 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
P/L 21979 Fn3-47 24 rs773647071 0.2153 -0.554 1.0 N 0.871 0.446 None gnomAD-2.1.1 2.82E-05 None None None None N None 0 0 None 0 2.8093E-04 None 0 None 0 1.78E-05 0
P/L 21979 Fn3-47 24 rs773647071 0.2153 -0.554 1.0 N 0.871 0.446 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 2.94E-05 0 0
P/L 21979 Fn3-47 24 rs773647071 0.2153 -0.554 1.0 N 0.871 0.446 None gnomAD-4.0.0 1.05413E-05 None None None None N None 0 1.6685E-05 None 0 6.70901E-05 None 0 1.64745E-04 9.32763E-06 0 1.60256E-05
P/Q 21979 Fn3-47 24 None 0.2749 None 1.0 N 0.865 0.461 0.550589291799 gnomAD-4.0.0 1.36917E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79966E-06 0 0
P/R 21979 Fn3-47 24 rs773647071 0.3113 -1.048 1.0 N 0.891 0.453 0.610832418033 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
P/R 21979 Fn3-47 24 rs773647071 0.3113 -1.048 1.0 N 0.891 0.453 0.610832418033 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/R 21979 Fn3-47 24 rs773647071 0.3113 -1.048 1.0 N 0.891 0.453 0.610832418033 gnomAD-4.0.0 6.58042E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47124E-05 0 0
P/S 21979 Fn3-47 24 None 0.3121 None 0.999 N 0.781 0.386 0.376216005999 gnomAD-4.0.0 1.59322E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43386E-05 0
K/E 22179 Fn3-49 24 rs747865430 0.5662 0.127 0.999 N 0.637 0.368 0.306695030598 gnomAD-2.1.1 8.33E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.24E-06 1.71292E-04
K/E 22179 Fn3-49 24 rs747865430 0.5662 0.127 0.999 N 0.637 0.368 0.306695030598 gnomAD-4.0.0 3.20492E-06 None None None None I None 0 0 None 0 0 None 0 0 2.87543E-06 0 3.04229E-05
P/L 22377 Fn3-50 24 rs771093991 0.1547 -0.572 0.976 N 0.747 0.473 0.75672024113 gnomAD-2.1.1 2.42E-05 None None None None I None 0 0 None 0 0 None 1.96143E-04 None 0 0 0
P/L 22377 Fn3-50 24 rs771093991 0.1547 -0.572 0.976 N 0.747 0.473 0.75672024113 gnomAD-4.0.0 8.89758E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.50756E-04 0
K/N 22474 Fn3-51 24 rs780089189 0.8845 -1.63 1.0 N 0.723 0.342 0.221734844693 gnomAD-2.1.1 8.07E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
K/N 22474 Fn3-51 24 rs780089189 0.8845 -1.63 1.0 N 0.723 0.342 0.221734844693 gnomAD-4.0.0 1.36882E-06 None None None None N None 0 4.47387E-05 None 0 0 None 0 0 0 0 0
P/H 22667 Fn3-52 25 None 0.3045 None 1.0 N 0.866 0.446 0.554037457546 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
D/E 22766 Fn3-53 24 rs534340303 0.1777 -0.47 0.767 N 0.326 0.083 0.104622674875 gnomAD-2.1.1 1.22115E-04 None None None None N None 0 0 None 0 1.77083E-03 None 0 None 0 0 0
D/E 22766 Fn3-53 24 rs534340303 0.1777 -0.47 0.767 N 0.326 0.083 0.104622674875 gnomAD-3.1.2 5.92E-05 None None None None N None 0 0 0 0 1.74554E-03 None 0 0 0 0 0
D/E 22766 Fn3-53 24 rs534340303 0.1777 -0.47 0.767 N 0.326 0.083 0.104622674875 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 2E-03 0 None None None 0 None
D/E 22766 Fn3-53 24 rs534340303 0.1777 -0.47 0.767 N 0.326 0.083 0.104622674875 gnomAD-4.0.0 4.03215E-05 None None None None N None 0 0 None 0 1.3008E-03 None 0 0 0 0 1.12194E-04
D/H 22766 Fn3-53 24 rs759955348 0.4319 0.319 1.0 N 0.791 0.409 0.253205268125 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 3.3E-05 None 0 0 0
D/H 22766 Fn3-53 24 rs759955348 0.4319 0.319 1.0 N 0.791 0.409 0.253205268125 gnomAD-4.0.0 1.5953E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43885E-05 0
P/S 23063 Fn3-55 24 None 0.1476 None 1.0 N 0.86 0.458 0.41219620536 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/F 23458 Fn3-58 24 rs1709865828 0.1684 None 0.884 N 0.503 0.199 0.51754283126 gnomAD-4.0.0 1.5919E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02572E-05
K/R 23555 Fn3-59 24 rs1246011660 0.104 -0.545 0.009 N 0.395 0.144 0.323886383625 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
K/R 23555 Fn3-59 24 rs1246011660 0.104 -0.545 0.009 N 0.395 0.144 0.323886383625 gnomAD-4.0.0 1.59159E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85901E-06 0 0
P/S 23750 Fn3-60 25 rs1308116861 0.136 -2.049 0.865 N 0.621 0.217 None gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.02E-06 0
P/S 23750 Fn3-60 25 rs1308116861 0.136 -2.049 0.865 N 0.621 0.217 None gnomAD-4.0.0 6.84612E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99722E-07 0 0
P/T 23750 Fn3-60 25 rs1308116861 0.0999 None 0.978 N 0.703 0.285 0.518970300747 gnomAD-4.0.0 6.84612E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99722E-07 0 0
E/K 23849 Fn3-61 24 None 0.1157 None 0.999 N 0.609 0.396 0.361160317528 gnomAD-4.0.0 1.59194E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8595E-06 0 0
K/N 23947 Fn3-62 24 rs56019808 0.4859 0.346 0.942 N 0.569 0.239 0.227934060464 gnomAD-2.1.1 1.78941E-04 None None None None N None 1.5709E-03 2.83254E-04 None 0 0 None 0 None 0 7.84E-06 1.40805E-04
K/N 23947 Fn3-62 24 rs56019808 0.4859 0.346 0.942 N 0.569 0.239 0.227934060464 gnomAD-3.1.2 5.52203E-04 None None None None N None 1.76116E-03 5.23834E-04 0 0 0 None 0 0 2.94E-05 0 4.77555E-04
K/N 23947 Fn3-62 24 rs56019808 0.4859 0.346 0.942 N 0.569 0.239 0.227934060464 1000 genomes 5.99042E-04 None None None None N None 2.3E-03 0 None None 0 0 None None None 0 None
K/N 23947 Fn3-62 24 rs56019808 0.4859 0.346 0.942 N 0.569 0.239 0.227934060464 gnomAD-4.0.0 9.17307E-05 None None None None N None 1.45291E-03 2.9999E-04 None 0 0 None 0 0 4.23872E-06 0 2.56107E-04
P/R 24146 Fn3-63 25 rs1184232674 0.2045 -1.184 0.999 N 0.781 0.472 0.520586239559 gnomAD-2.1.1 5.49E-06 None None None None N None 0 0 None 0 0 None 6.49E-05 None 0 0 0
P/R 24146 Fn3-63 25 rs1184232674 0.2045 -1.184 0.999 N 0.781 0.472 0.520586239559 gnomAD-4.0.0 1.8529E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.42489E-05
H/Y 24245 Fn3-64 24 rs375467956 0.1037 1.025 0.662 N 0.565 0.237 None gnomAD-2.1.1 1.7E-05 None None None None N None 1.37836E-04 4.78E-05 None 0 0 None 0 None 0 0 0
H/Y 24245 Fn3-64 24 rs375467956 0.1037 1.025 0.662 N 0.565 0.237 None gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
H/Y 24245 Fn3-64 24 rs375467956 0.1037 1.025 0.662 N 0.565 0.237 None gnomAD-4.0.0 4.36722E-06 None None None None N None 3.57436E-05 2.28613E-05 None 0 0 None 0 0 0 0 0
P/L 24542 Fn3-66 24 None 0.0964 None 0.991 N 0.691 0.453 0.566193126947 gnomAD-4.0.0 6.84383E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99607E-07 0 0
P/R 24542 Fn3-66 24 rs901760899 0.463 None 0.991 N 0.715 0.456 0.587058026133 gnomAD-4.0.0 3.42192E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59843E-06 0 1.65706E-05
P/T 24542 Fn3-66 24 None 0.1047 None 0.805 N 0.601 0.334 0.479286488449 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/S 24832 Fn3-68 25 None 0.234 None 1.0 N 0.858 0.466 0.468085328875 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/D 24931 Fn3-69 24 rs1314632891 0.247 -0.815 0.472 N 0.475 0.059 0.183819452728 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
E/D 24931 Fn3-69 24 rs1314632891 0.247 -0.815 0.472 N 0.475 0.059 0.183819452728 gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/D 24931 Fn3-69 24 rs1314632891 0.247 -0.815 0.472 N 0.475 0.059 0.183819452728 gnomAD-4.0.0 1.31532E-05 None None None None I None 4.82742E-05 0 None 0 0 None 0 0 0 0 0
E/K 24931 Fn3-69 24 rs369679134 0.1379 0.018 0.012 N 0.147 0.205 None gnomAD-2.1.1 1.07E-05 None None None None I None 0 0 None 0 5.14E-05 None 0 None 0 1.57E-05 0
E/K 24931 Fn3-69 24 rs369679134 0.1379 0.018 0.012 N 0.147 0.205 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 2.88351E-04 1.94024E-04 None 0 0 1.47E-05 0 0
E/K 24931 Fn3-69 24 rs369679134 0.1379 0.018 0.012 N 0.147 0.205 None gnomAD-4.0.0 1.36366E-05 None None None None I None 0 0 None 6.7595E-05 2.23174E-05 None 0 0 1.52595E-05 0 1.60174E-05
K/E 25029 Fn3-70 24 None 0.2551 None 0.989 N 0.539 0.254 0.251116650651 gnomAD-4.0.0 1.59439E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86618E-06 0 0
P/S 25228 Fn3-71 25 rs377226540 0.202 -2.621 0.31 N 0.284 0.29 None gnomAD-2.1.1 1.0753E-04 None None None None N None 1.20013E-03 0 None 0 0 None 0 None 0 7.86E-06 0
P/S 25228 Fn3-71 25 rs377226540 0.202 -2.621 0.31 N 0.284 0.29 None gnomAD-3.1.2 2.69691E-04 None None None None N None 9.89812E-04 0 0 0 0 None 0 0 0 0 0
P/S 25228 Fn3-71 25 rs377226540 0.202 -2.621 0.31 N 0.284 0.29 None 1000 genomes 5.99042E-04 None None None None N None 2.3E-03 0 None None 0 0 None None None 0 None
P/S 25228 Fn3-71 25 rs377226540 0.202 -2.621 0.31 N 0.284 0.29 None gnomAD-4.0.0 4.95903E-05 None None None None N None 1.02678E-03 0 None 0 0 None 0 0 0 0 4.80492E-05
R/S 25327 Fn3-72 24 None 0.7134 None 0.805 D 0.615 0.225 0.213573922156 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/R 25428 Fn3-73 24 rs1264945919 0.0925 -0.143 0.892 N 0.557 0.205 0.210429274316 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 0 0
K/R 25428 Fn3-73 24 rs1264945919 0.0925 -0.143 0.892 N 0.557 0.205 0.210429274316 gnomAD-4.0.0 1.59186E-06 None None None None N None 0 0 None 0 0 None 1.8831E-05 0 0 0 0
P/A 25624 Fn3-74 24 None 0.0749 None 0.807 N 0.699 0.381 0.240491677333 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
P/L 25624 Fn3-74 24 None 0.1087 None 0.994 N 0.853 0.451 0.685676517872 gnomAD-4.0.0 1.61278E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8958E-06 0 0
K/Q 25721 Fn3-75 24 None 0.4486 None 0.998 N 0.727 0.398 0.278968121808 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/R 25914 Fn3-76 25 rs774671830 0.3347 -1.107 0.989 N 0.884 0.485 0.652424105921 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 0 0
P/R 25914 Fn3-76 25 rs774671830 0.3347 -1.107 0.989 N 0.884 0.485 0.652424105921 gnomAD-4.0.0 1.59268E-06 None None None None N None 0 0 None 0 0 None 1.88445E-05 0 0 0 0
P/S 25914 Fn3-76 25 None 0.1844 None 0.989 N 0.808 0.439 0.465038187318 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
E/D 26013 Fn3-77 24 rs755117644 0.3336 -1.051 0.822 N 0.572 0.113 0.191931220699 gnomAD-2.1.1 2.42E-05 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 4.46E-05 0
E/D 26013 Fn3-77 24 rs755117644 0.3336 -1.051 0.822 N 0.572 0.113 0.191931220699 gnomAD-3.1.2 4.6E-05 None None None None I None 2.41E-05 6.55E-05 0 0 0 None 0 0 7.35E-05 0 0
E/D 26013 Fn3-77 24 rs755117644 0.3336 -1.051 0.822 N 0.572 0.113 0.191931220699 gnomAD-4.0.0 4.64872E-05 None None None None I None 4.00545E-05 3.336E-05 None 0 0 None 0 0 5.67982E-05 0 4.80538E-05
P/L 26310 Fn3-79 25 rs754702040 0.1019 -0.54 0.004 N 0.501 0.347 None gnomAD-2.1.1 3.95E-05 None None None None N None 0 0 None 0 0 None 3.29E-05 None 0 7.87E-05 0
P/L 26310 Fn3-79 25 rs754702040 0.1019 -0.54 0.004 N 0.501 0.347 None gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 7.35E-05 0 0
P/L 26310 Fn3-79 25 rs754702040 0.1019 -0.54 0.004 N 0.501 0.347 None gnomAD-4.0.0 5.21096E-05 None None None None N None 0 0 None 0 0 None 0 0 6.87108E-05 2.19974E-05 1.60333E-05
P/T 26310 Fn3-79 25 rs1260101727 0.1163 -1.908 0.638 N 0.625 0.435 0.417334834585 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
P/T 26310 Fn3-79 25 rs1260101727 0.1163 -1.908 0.638 N 0.625 0.435 0.417334834585 gnomAD-4.0.0 1.59551E-06 None None None None N None 0 0 None 0 2.77562E-05 None 0 0 0 0 0
R/C 26409 Fn3-80 24 rs748258568 0.3414 -0.466 0.999 N 0.709 0.402 0.66441189913 gnomAD-2.1.1 2.42E-05 None None None None N None 6.47E-05 2.9E-05 None 0 0 None 1.30719E-04 None 0 0 0
R/C 26409 Fn3-80 24 rs748258568 0.3414 -0.466 0.999 N 0.709 0.402 0.66441189913 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/C 26409 Fn3-80 24 rs748258568 0.3414 -0.466 0.999 N 0.709 0.402 0.66441189913 gnomAD-4.0.0 1.3636E-05 None None None None N None 2.67158E-05 1.66789E-05 None 0 0 None 0 0 3.39078E-06 1.64716E-04 0
R/H 26409 Fn3-80 24 rs72648206 0.1884 -1.254 1.0 N 0.643 0.355 None gnomAD-2.1.1 5.68739E-04 None None None None N None 2.07056E-04 1.13231E-04 None 2.90473E-04 2.57017E-04 None 3.92157E-04 None 0 9.95516E-04 4.21704E-04
R/H 26409 Fn3-80 24 rs72648206 0.1884 -1.254 1.0 N 0.643 0.355 None gnomAD-3.1.2 6.7062E-04 None None None None N None 1.68935E-04 1.96721E-04 0 0 3.86698E-04 None 0 0 1.294E-03 2.07297E-04 4.77555E-04
R/H 26409 Fn3-80 24 rs72648206 0.1884 -1.254 1.0 N 0.643 0.355 None gnomAD-4.0.0 8.57715E-04 None None None None N None 1.73315E-04 1.33387E-04 None 6.75767E-05 1.33881E-04 None 0 1.65017E-04 1.09267E-03 3.95283E-04 4.64253E-04
P/H 26996 Fn3-84 25 None 0.4147 None 1.0 D 0.859 0.575 0.722947621725 gnomAD-4.0.0 1.59231E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85986E-06 0 0
P/S 26996 Fn3-84 25 rs561588883 0.2242 -2.188 0.987 N 0.757 0.385 0.384252928164 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
P/S 26996 Fn3-84 25 rs561588883 0.2242 -2.188 0.987 N 0.757 0.385 0.384252928164 gnomAD-4.0.0 3.18461E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85995E-06 0 3.02535E-05
P/T 26996 Fn3-84 25 rs561588883 0.1591 -1.942 0.993 N 0.78 0.447 0.566228512615 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
P/T 26996 Fn3-84 25 rs561588883 0.1591 -1.942 0.993 N 0.78 0.447 0.566228512615 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06868E-04 0
P/T 26996 Fn3-84 25 rs561588883 0.1591 -1.942 0.993 N 0.78 0.447 0.566228512615 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
P/T 26996 Fn3-84 25 rs561588883 0.1591 -1.942 0.993 N 0.78 0.447 0.566228512615 gnomAD-4.0.0 6.56866E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07039E-04 0
E/K 27095 Fn3-85 24 rs1415718775 0.12 None 0.285 N 0.379 0.251 0.252681307341 gnomAD-4.0.0 1.36893E-06 None None None None N None 0 0 None 0 0 None 0 0 8.9959E-07 1.16044E-05 0
K/N 27193 Fn3-86 24 rs565307960 0.61 -1.306 0.942 N 0.483 0.291 0.186928172975 gnomAD-2.1.1 5.26E-05 None None None None N None 6.51E-05 0 None 0 0 None 0 None 3.73622E-04 3.58E-05 0
K/N 27193 Fn3-86 24 rs565307960 0.61 -1.306 0.942 N 0.483 0.291 0.186928172975 gnomAD-4.0.0 6.84501E-07 None None None None N None 2.98936E-05 0 None 0 0 None 0 0 0 0 0
P/A 27393 Fn3-87 25 None 0.0822 None 0.014 D 0.28 0.26 0.242825505644 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
P/L 27393 Fn3-87 25 rs1267590455 0.1176 -0.616 0.698 N 0.608 0.413 0.644453097843 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
P/L 27393 Fn3-87 25 rs1267590455 0.1176 -0.616 0.698 N 0.608 0.413 0.644453097843 gnomAD-4.0.0 1.59142E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
R/C 27492 Fn3-88 24 rs767221784 0.2291 -0.26 0.159 N 0.424 0.246 0.516162830352 gnomAD-2.1.1 2.85E-05 None None None None N None 4.13E-05 1.13116E-04 None 0 5.13E-05 None 0 None 0 1.56E-05 0
R/C 27492 Fn3-88 24 rs767221784 0.2291 -0.26 0.159 N 0.424 0.246 0.516162830352 gnomAD-3.1.2 3.29E-05 None None None None N None 4.83E-05 6.56E-05 0 0 0 None 0 0 2.94E-05 0 0
R/C 27492 Fn3-88 24 rs767221784 0.2291 -0.26 0.159 N 0.424 0.246 0.516162830352 gnomAD-4.0.0 1.73528E-05 None None None None N None 4.00716E-05 1.16729E-04 None 0 2.22975E-05 None 0 0 1.10191E-05 3.29381E-05 1.60097E-05
R/G 27492 Fn3-88 24 None 0.512 None 0.96 N 0.599 0.288 0.499473279415 gnomAD-4.0.0 6.84197E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99471E-07 0 0
R/H 27492 Fn3-88 24 rs375752919 0.1462 -1.118 1.0 N 0.619 0.319 None gnomAD-2.1.1 1.21E-05 None None None None N None 6.46E-05 0 None 0 0 None 3.27E-05 None 0 8.88E-06 0
R/H 27492 Fn3-88 24 rs375752919 0.1462 -1.118 1.0 N 0.619 0.319 None gnomAD-4.0.0 6.15777E-06 None None None None N None 5.9755E-05 0 None 0 2.51965E-05 None 0 0 4.49736E-06 1.15937E-05 0
K/Q 27593 Fn3-89 24 None 0.2298 None 0.901 N 0.595 0.231 0.262662153117 gnomAD-4.0.0 3.18321E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71729E-06 0 0
P/A 27789 Fn3-90 24 rs1704156538 0.0796 None 0.008 N 0.363 0.204 0.231873229951 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
P/A 27789 Fn3-90 24 rs1704156538 0.0796 None 0.008 N 0.363 0.204 0.231873229951 gnomAD-4.0.0 6.57436E-06 None None None None I None 2.41359E-05 0 None 0 0 None 0 0 0 0 0
P/T 27789 Fn3-90 24 rs1704156538 0.1408 None 0.805 N 0.628 0.354 0.407767136052 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 28177 Fn3-93 24 rs532274400 0.107 -1.399 0.001 N 0.113 0.082 0.33835085245 gnomAD-2.1.1 7.17E-06 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 7.84E-06 0
V/A 28177 Fn3-93 24 rs532274400 0.107 -1.399 0.001 N 0.113 0.082 0.33835085245 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 28177 Fn3-93 24 rs532274400 0.107 -1.399 0.001 N 0.113 0.082 0.33835085245 gnomAD-4.0.0 2.56442E-06 None None None None I None 0 0 None 0 0 None 0 0 2.39458E-06 1.34167E-05 0
V/E 28177 Fn3-93 24 rs532274400 0.1223 -1.184 0.001 N 0.288 0.261 0.386882687439 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92901E-04 None 0 0 0 0 0
V/E 28177 Fn3-93 24 rs532274400 0.1223 -1.184 0.001 N 0.288 0.261 0.386882687439 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
V/E 28177 Fn3-93 24 rs532274400 0.1223 -1.184 0.001 N 0.288 0.261 0.386882687439 gnomAD-4.0.0 6.56728E-06 None None None None I None 0 0 None 0 1.93349E-04 None 0 0 0 0 0
V/L 28177 Fn3-93 24 None 0.1395 None 0.029 N 0.255 0.046 0.395441342475 gnomAD-4.0.0 6.84535E-07 None None None None I None 0 0 None 0 0 None 1.87484E-05 0 0 0 0
V/M 28177 Fn3-93 24 None 0.1071 None 0.036 N 0.267 0.069 0.379881503574 gnomAD-4.0.0 6.84535E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99696E-07 0 0
K/N 28275 Fn3-94 24 rs765009136 0.6575 -0.493 0.879 N 0.587 0.27 0.18995819373 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
K/N 28275 Fn3-94 24 rs765009136 0.6575 -0.493 0.879 N 0.587 0.27 0.18995819373 gnomAD-4.0.0 1.3684E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79889E-06 0 0
K/Q 28275 Fn3-94 24 None 0.1491 None 0.879 N 0.627 0.237 0.159798565429 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
R/C 28474 Fn3-95 25 rs757771061 0.1037 -0.037 0.964 N 0.44 0.257 0.60657190734 gnomAD-2.1.1 2.86E-05 None None None None N None 4.14E-05 5.66E-05 None 0 0 None 3.27E-05 None 0 2.35E-05 1.40449E-04
R/C 28474 Fn3-95 25 rs757771061 0.1037 -0.037 0.964 N 0.44 0.257 0.60657190734 gnomAD-3.1.2 1.97E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 4.77555E-04
R/C 28474 Fn3-95 25 rs757771061 0.1037 -0.037 0.964 N 0.44 0.257 0.60657190734 gnomAD-4.0.0 1.42549E-05 None None None None N None 4.00545E-05 5.002E-05 None 0 4.46648E-05 None 0 1.6442E-04 6.78083E-06 1.09796E-05 8.00589E-05
R/H 28474 Fn3-95 25 rs754356257 0.0851 -0.972 0.877 N 0.52 0.217 0.162503812791 gnomAD-2.1.1 1.68043E-04 None None None None N None 4.14E-05 2.83E-05 None 0 0 None 1.43819E-03 None 0 7.82E-06 0
R/H 28474 Fn3-95 25 rs754356257 0.0851 -0.972 0.877 N 0.52 0.217 0.162503812791 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 6.20604E-04 0
R/H 28474 Fn3-95 25 rs754356257 0.0851 -0.972 0.877 N 0.52 0.217 0.162503812791 gnomAD-4.0.0 8.98657E-05 None None None None N None 2.67001E-05 1.66783E-05 None 0 2.23274E-05 None 0 0 2.28854E-05 1.16371E-03 1.28098E-04
R/K 28573 Fn3-96 24 None 0.1415 None 0.656 N 0.567 0.158 0.3085936734 gnomAD-4.0.0 1.59155E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.0248E-05
V/A 28868 Fn3-98 24 rs1702826806 0.158 None 0.001 N 0.131 0.032 0.298403945805 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 28868 Fn3-98 24 rs1702826806 0.158 None 0.001 N 0.131 0.032 0.298403945805 gnomAD-4.0.0 6.57073E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
V/I 28868 Fn3-98 24 rs754143034 0.0713 -0.486 0.166 N 0.461 0.032 0.28492961333 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
V/I 28868 Fn3-98 24 rs754143034 0.0713 -0.486 0.166 N 0.461 0.032 0.28492961333 gnomAD-4.0.0 2.7369E-06 None None None None N None 0 0 None 0 0 None 0 0 3.598E-06 0 0
P/A 29161 Fn3-100 25 None 0.0706 None 0.767 N 0.374 0.335 0.283761946502 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
P/H 29557 Fn3-103 25 None 0.2528 None 1.0 N 0.868 0.472 0.602320007227 gnomAD-4.0.0 1.591E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85778E-06 0 0
R/G 29656 Fn3-104 24 None 0.5565 None 1.0 N 0.691 0.358 0.599206028305 gnomAD-4.0.0 6.8427E-07 None None None None I None 2.98846E-05 0 None 0 0 None 0 0 0 0 0
P/L 29956 Fn3-106 24 None 0.1257 None 0.549 N 0.518 0.503 0.659023422603 gnomAD-4.0.0 2.05542E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79899E-06 0 1.65717E-05
P/S 29956 Fn3-106 24 rs773071868 0.1488 -1.855 0.007 N 0.243 0.223 0.27132560031 gnomAD-2.1.1 8.1E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
P/S 29956 Fn3-106 24 rs773071868 0.1488 -1.855 0.007 N 0.243 0.223 0.27132560031 gnomAD-4.0.0 4.11062E-06 None None None None I None 0 0 None 0 0 None 0 0 2.6985E-06 3.47858E-05 0
K/N 30053 Fn3-107 24 rs886039117 0.9424 None 0.998 N 0.687 0.33 0.207176502487 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/N 30053 Fn3-107 24 rs886039117 0.9424 None 0.998 N 0.687 0.33 0.207176502487 gnomAD-4.0.0 2.56176E-06 None None None None N None 3.38146E-05 0 None 0 0 None 0 0 0 0 0
V/I 30248 Fn3-108 25 rs727505024 0.0688 -0.318 None N 0.181 0.073 0.394079506076 gnomAD-2.1.1 1.00607E-04 None None None None N None 0 6.95935E-04 None 0 0 None 0 None 0 0 1.65837E-04
V/I 30248 Fn3-108 25 rs727505024 0.0688 -0.318 None N 0.181 0.073 0.394079506076 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.3113E-04 0 0 0 None 0 0 0 0 0
V/I 30248 Fn3-108 25 rs727505024 0.0688 -0.318 None N 0.181 0.073 0.394079506076 gnomAD-4.0.0 3.84326E-05 None None None None N None 0 5.08613E-04 None 0 0 None 0 0 0 0 0
A/T 30347 Fn3-109 24 None 0.0767 None 0.884 D 0.36 0.186 0.35139820857 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
P/Q 30445 Fn3-110 24 rs749169334 0.1696 -1.062 0.966 N 0.621 0.302 0.432936702747 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
P/Q 30445 Fn3-110 24 rs749169334 0.1696 -1.062 0.966 N 0.621 0.302 0.432936702747 gnomAD-4.0.0 1.36864E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79913E-06 0 0
P/R 30445 Fn3-110 24 None 0.2229 None 0.966 N 0.636 0.323 0.443388199986 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
P/R 30445 Fn3-110 24 None 0.2229 None 0.966 N 0.636 0.323 0.443388199986 gnomAD-4.0.0 4.79026E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29696E-06 0 0
P/S 30445 Fn3-110 24 None 0.1861 None 0.454 N 0.444 0.173 0.225215365344 gnomAD-4.0.0 1.5919E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85928E-06 0 0
A/D 30643 Fn3-111 25 None 0.2064 None 0.984 N 0.623 0.305 0.653762920561 gnomAD-4.0.0 1.37123E-06 None None None None I None 0 0 None 0 0 None 0 0 9.01427E-07 1.16131E-05 0
A/V 30643 Fn3-111 25 rs750203753 0.0945 -0.112 0.946 N 0.473 0.273 0.496891249646 gnomAD-2.1.1 3.22E-05 None None None None I None 0 0 None 0 0 None 6.56E-05 None 4.66E-05 4.45E-05 0
A/V 30643 Fn3-111 25 rs750203753 0.0945 -0.112 0.946 N 0.473 0.273 0.496891249646 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 2.07555E-04 0
A/V 30643 Fn3-111 25 rs750203753 0.0945 -0.112 0.946 N 0.473 0.273 0.496891249646 gnomAD-4.0.0 2.1728E-05 None None None None I None 0 0 None 0 0 None 0 0 2.29323E-05 6.59892E-05 3.20914E-05
R/K 30742 Fn3-112 24 rs1698436310 0.1363 None 0.997 N 0.565 0.298 0.231873229951 gnomAD-4.0.0 3.18285E-06 None None None None N None 0 4.57373E-05 None 0 0 None 0 0 0 0 0
R/W 30742 Fn3-112 24 rs1698437169 0.2422 None 1.0 D 0.788 0.484 0.384252928164 gnomAD-4.0.0 3.18296E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71706E-06 0 0
A/G 31039 Fn3-114 24 rs1188711854 0.2114 None 0.996 D 0.545 0.348 0.592600369099 gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
A/G 31039 Fn3-114 24 rs1188711854 0.2114 None 0.996 D 0.545 0.348 0.592600369099 gnomAD-4.0.0 1.97187E-05 None None None None I None 7.23833E-05 0 None 0 0 None 0 0 0 0 0
A/S 31039 Fn3-114 24 rs1442882348 0.1175 -1.331 0.957 N 0.349 0.123 0.478605750892 gnomAD-2.1.1 3.18E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
A/S 31039 Fn3-114 24 rs1442882348 0.1175 -1.331 0.957 N 0.349 0.123 0.478605750892 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/S 31039 Fn3-114 24 rs1442882348 0.1175 -1.331 0.957 N 0.349 0.123 0.478605750892 gnomAD-4.0.0 6.57229E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47007E-05 0 0
A/T 31039 Fn3-114 24 None 0.1216 None 0.992 N 0.623 0.274 0.556972862284 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/V 31039 Fn3-114 24 None 0.1479 None 0.998 N 0.651 0.325 0.604342690544 gnomAD-4.0.0 1.59111E-06 None None None None I None 0 0 None 0 2.77254E-05 None 0 0 0 0 0
K/I 31136 Fn3-115 24 rs1697982034 0.8689 None 1.0 N 0.797 0.594 0.539970339866 gnomAD-4.0.0 1.27286E-05 None None None None N None 0 0 None 0 2.21803E-04 None 0 0 0 0 0
K/N 31136 Fn3-115 24 None 0.959 None 1.0 N 0.718 0.383 0.18995819373 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
E/V 31332 Fn3-116 25 rs766706869 0.1476 0.211 0.999 N 0.69 0.358 0.424549175451 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.8E-05 None 0 0 0
E/V 31332 Fn3-116 25 rs766706869 0.1476 0.211 0.999 N 0.69 0.358 0.424549175451 gnomAD-4.0.0 9.54675E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57437E-06 4.29812E-05 0
E/G 31431 Fn3-117 24 None 0.2279 None 0.986 N 0.549 0.311 0.414798848334 gnomAD-4.0.0 1.5913E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
A/T 31529 Fn3-118 24 rs947067361 0.0862 None 0.051 N 0.325 0.073 0.388970301349 gnomAD-4.0.0 1.37669E-06 None None None None I None 0 0 None 0 0 None 0 0 1.8097E-06 0 0
A/V 31529 Fn3-118 24 None 0.0857 None 0.022 N 0.13 0.151 0.459552425292 gnomAD-4.0.0 1.60904E-06 None None None None I None 0 0 None 0 0 None 0 0 2.90271E-06 0 0
L/I 31731 Fn3-119 24 rs1364685585 0.072 -0.643 None N 0.079 0.06 0.230578612272 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
L/I 31731 Fn3-119 24 rs1364685585 0.072 -0.643 None N 0.079 0.06 0.230578612272 gnomAD-4.0.0 1.59148E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02444E-05
I/T 32128 Fn3-122 24 None 0.1801 None 0.002 N 0.288 0.149 0.458013479912 gnomAD-4.0.0 1.60769E-06 None None None None N None 0 0 None 0 0 None 2.12558E-05 0 0 0 0
K/E 32225 Fn3-123 24 rs749032092 0.6255 -0.612 0.997 N 0.614 0.389 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
K/E 32225 Fn3-123 24 rs749032092 0.6255 -0.612 0.997 N 0.614 0.389 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/E 32225 Fn3-123 24 rs749032092 0.6255 -0.612 0.997 N 0.614 0.389 None gnomAD-4.0.0 6.57367E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47033E-05 0 0
P/A 32423 Fn3-124 25 rs1225502808 0.0681 -1.575 0.016 N 0.291 0.156 0.136095386433 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
P/A 32423 Fn3-124 25 rs1225502808 0.0681 -1.575 0.016 N 0.291 0.156 0.136095386433 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/A 32423 Fn3-124 25 rs1225502808 0.0681 -1.575 0.016 N 0.291 0.156 0.136095386433 gnomAD-4.0.0 6.57125E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46998E-05 0 0
P/S 32423 Fn3-124 25 None 0.1305 None 0.716 N 0.611 0.318 0.239305524855 gnomAD-4.0.0 1.59347E-06 None None None None N None 0 0 None 0 2.77747E-05 None 0 0 0 0 0
P/T 32423 Fn3-124 25 None 0.1055 None 0.898 N 0.69 0.391 0.376039117802 gnomAD-4.0.0 1.59347E-06 None None None None N None 0 0 None 0 0 None 1.88345E-05 0 0 0 0
V/A 32623 Fn3-126 24 rs1171694976 0.0973 -1.291 0.081 N 0.354 0.139 0.423716096872 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
V/A 32623 Fn3-126 24 rs1171694976 0.0973 -1.291 0.081 N 0.354 0.139 0.423716096872 gnomAD-4.0.0 1.5913E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
R/Q 32920 Fn3-128 25 rs752015224 0.3257 -0.483 1.0 N 0.742 0.317 None gnomAD-2.1.1 6.42E-05 None None None None N None 0 8.49E-05 None 0 0 None 1.63388E-04 None 1.19933E-04 5.46E-05 0
R/Q 32920 Fn3-128 25 rs752015224 0.3257 -0.483 1.0 N 0.742 0.317 None gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 1.88857E-04 0 4.41E-05 0 0
R/Q 32920 Fn3-128 25 rs752015224 0.3257 -0.483 1.0 N 0.742 0.317 None gnomAD-4.0.0 3.84243E-05 None None None None N None 1.3359E-05 8.3375E-05 None 0 2.22876E-05 None 1.09399E-04 0 2.79719E-05 1.53718E-04 1.60118E-05
R/W 32920 Fn3-128 25 rs755031142 0.5416 -0.327 1.0 N 0.785 0.441 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
R/W 32920 Fn3-128 25 rs755031142 0.5416 -0.327 1.0 N 0.785 0.441 None gnomAD-4.0.0 6.15791E-06 None None None None N None 0 6.70901E-05 None 0 0 None 0 0 3.59794E-06 1.15931E-05 1.65656E-05
K/R 33021 Fn3-129 24 rs749757136 0.0879 -0.195 0.011 N 0.251 0.104 0.253205268125 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
K/R 33021 Fn3-129 24 rs749757136 0.0879 -0.195 0.011 N 0.251 0.104 0.253205268125 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/R 33021 Fn3-129 24 rs749757136 0.0879 -0.195 0.011 N 0.251 0.104 0.253205268125 gnomAD-4.0.0 2.54085E-05 None None None None N None 0 0 None 0 0 None 0 0 3.47535E-05 0 0
P/L 33314 Fn3-130 25 None 0.2153 None 0.698 N 0.63 0.47 0.638834684723 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
P/S 33314 Fn3-130 25 rs754605294 0.2628 -1.696 0.698 N 0.553 0.265 None gnomAD-2.1.1 3.58E-05 None None None None N None 2.06748E-04 1.41739E-04 None 0 0 None 0 None 0 0 0
P/S 33314 Fn3-130 25 rs754605294 0.2628 -1.696 0.698 N 0.553 0.265 None gnomAD-3.1.2 4.6E-05 None None None None N None 1.68943E-04 0 0 0 0 None 0 0 0 0 0
P/S 33314 Fn3-130 25 rs754605294 0.2628 -1.696 0.698 N 0.553 0.265 None gnomAD-4.0.0 1.17756E-05 None None None None N None 1.46874E-04 1.0006E-04 None 0 0 None 0 0 0 0 3.20287E-05
P/A 33415 Fn3-131 24 None 0.0855 None 0.767 N 0.41 0.339 0.33440975612 gnomAD-4.0.0 7.10326E-07 None None None None N None 0 0 None 0 0 None 0 0 9.20778E-07 0 0
P/L 33415 Fn3-131 24 rs72648282 0.1585 -0.651 0.999 N 0.823 0.521 0.564020812232 Taylor (2011) None ARVC het None None N Genetic analysis of TTN in 38 ARVC families; unknown penetrance None None None None None None None None None None None
P/L 33415 Fn3-131 24 rs72648282 0.1585 -0.651 0.999 N 0.823 0.521 0.564020812232 gnomAD-4.0.0 3.47766E-06 None None None None N None 0 0 None 0 0 None 0 0 6.16717E-06 0 0
P/S 33415 Fn3-131 24 None 0.1982 None 0.998 N 0.75 0.444 0.441221003447 gnomAD-4.0.0 7.10326E-07 None None None None N None 0 0 None 0 0 None 0 0 9.20778E-07 0 0
P/T 33415 Fn3-131 24 None 0.1694 None 0.999 N 0.771 0.486 0.487983534966 gnomAD-4.0.0 7.10326E-07 None None None None N None 0 0 None 0 0 None 0 0 9.20778E-07 0 0
E/D 33712 Fn3-132 24 rs1060503937 0.2254 -0.864 0.062 N 0.492 0.042 0.221734844693 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/D 33712 Fn3-132 24 rs1060503937 0.2254 -0.864 0.062 N 0.492 0.042 0.221734844693 gnomAD-4.0.0 6.84207E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.