Structural position:

  • Domain Type: Fn3
  • Aligned Position: 35
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand C

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
I/L 15689 Fn3-1 33 rs780698011 0.3597 -1.077 0.889 N 0.494 0.174 0.593972321423 gnomAD-2.1.1 8.08E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
I/L 15689 Fn3-1 33 rs780698011 0.3597 -1.077 0.889 N 0.494 0.174 0.593972321423 gnomAD-4.0.0 4.10825E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.9583E-05 0
I/N 15689 Fn3-1 33 None 0.9184 None 0.999 D 0.84 0.57 0.874120574325 gnomAD-4.0.0 1.59395E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86264E-06 0 0
I/F 15790 Fn3-2 33 None 0.8853 None 0.864 D 0.731 0.429 0.445410361449 gnomAD-4.0.0 1.59351E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86259E-06 0 0
I/S 16187 Fn3-5 33 rs777279411 0.9849 -2.146 0.998 D 0.816 0.527 0.889955871483 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
I/S 16187 Fn3-5 33 rs777279411 0.9849 -2.146 0.998 D 0.816 0.527 0.889955871483 gnomAD-4.0.0 5.47719E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19972E-06 0 0
I/V 16187 Fn3-5 33 rs1312494208 0.1687 -1.424 0.333 N 0.264 0.087 0.472582640538 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/V 16187 Fn3-5 33 rs1312494208 0.1687 -1.424 0.333 N 0.264 0.087 0.472582640538 gnomAD-4.0.0 1.59365E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43377E-05 0
I/V 16482 Fn3-7 33 rs1029563364 0.0742 None 0.993 N 0.387 0.264 0.524792858863 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 16482 Fn3-7 33 rs1029563364 0.0742 None 0.993 N 0.387 0.264 0.524792858863 gnomAD-4.0.0 5.58158E-06 None None None None I None 0 1.66917E-05 None 0 0 None 0 0 6.7849E-06 0 0
I/T 16583 Fn3-8 33 rs372866841 0.6986 -2.18 0.645 D 0.773 0.481 None gnomAD-2.1.1 7.16E-06 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 0 0
I/T 16583 Fn3-8 33 rs372866841 0.6986 -2.18 0.645 D 0.773 0.481 None gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
I/T 16583 Fn3-8 33 rs372866841 0.6986 -2.18 0.645 D 0.773 0.481 None gnomAD-4.0.0 6.20118E-06 None None None None N None 2.6728E-05 0 None 0 0 None 0 0 5.93599E-06 1.09827E-05 0
I/T 16783 Fn3-10 33 rs950940404 0.9817 -2.095 0.978 D 0.745 0.535 None gnomAD-2.1.1 8.21E-06 None None None None I None 1.30839E-04 0 None 0 0 None 0 None 0 0 0
I/T 16783 Fn3-10 33 rs950940404 0.9817 -2.095 0.978 D 0.745 0.535 None gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
I/T 16783 Fn3-10 33 rs950940404 0.9817 -2.095 0.978 D 0.745 0.535 None gnomAD-4.0.0 6.43638E-06 None None None None I None 5.0863E-05 0 None 0 0 None 0 0 2.4014E-06 0 2.85649E-05
I/V 16783 Fn3-10 33 rs773959706 0.1757 -1.564 0.198 N 0.229 0.138 0.46435556306 gnomAD-2.1.1 8.2E-06 None None None None I None 0 5.91E-05 None 0 0 None 0 None 0 0 0
I/V 16783 Fn3-10 33 rs773959706 0.1757 -1.564 0.198 N 0.229 0.138 0.46435556306 gnomAD-4.0.0 2.05779E-06 None None None None I None 0 4.51916E-05 None 0 0 None 0 0 9.0061E-07 0 0
I/V 16884 Fn3-11 33 rs748958858 0.0982 -1.519 0.993 N 0.381 0.24 0.567605623258 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 1.12095E-04 None 0 None 9.29E-05 0 0
I/V 16884 Fn3-11 33 rs748958858 0.0982 -1.519 0.993 N 0.381 0.24 0.567605623258 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 16884 Fn3-11 33 rs748958858 0.0982 -1.519 0.993 N 0.381 0.24 0.567605623258 gnomAD-4.0.0 1.15411E-05 None None None None I None 0 0 None 0 4.8676E-05 None 7.8456E-05 0 2.39557E-06 1.34037E-05 0
I/V 17079 Fn3-12 33 None 0.086 None 0.4 N 0.228 0.104 0.455265801863 gnomAD-4.0.0 2.40064E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 1.3125E-06 0 0
I/T 17401 Fn3-14 33 rs1410389607 0.9709 None 1.0 D 0.807 0.556 0.750041221393 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 17401 Fn3-14 33 rs1410389607 0.9709 None 1.0 D 0.807 0.556 0.750041221393 gnomAD-4.0.0 6.58146E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47228E-05 0 0
I/T 17601 Fn3-16 33 rs774032287 0.7945 -2.06 0.978 N 0.762 0.511 None gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.67E-05 0
I/T 17601 Fn3-16 33 rs774032287 0.7945 -2.06 0.978 N 0.762 0.511 None gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 17601 Fn3-16 33 rs774032287 0.7945 -2.06 0.978 N 0.762 0.511 None gnomAD-4.0.0 6.82059E-06 None None None None I None 0 0 None 0 0 None 0 0 9.32731E-06 0 0
I/T 17894 Fn3-18 33 None 0.9046 None 0.989 N 0.813 0.58 0.693353280975 gnomAD-4.0.0 1.59557E-06 None None None None N None 0 0 None 0 2.78118E-05 None 0 0 0 0 0
I/V 17894 Fn3-18 33 rs1200778787 0.1284 -1.587 0.333 N 0.263 0.083 0.391000631824 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
I/V 17894 Fn3-18 33 rs1200778787 0.1284 -1.587 0.333 N 0.263 0.083 0.391000631824 gnomAD-4.0.0 1.59461E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86533E-06 0 0
I/T 18097 Fn3-19 33 rs1553681465 0.9563 None 0.98 N 0.701 0.521 0.720158938049 gnomAD-4.0.0 2.05417E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79998E-06 0 1.65826E-05
I/V 18097 Fn3-19 33 None 0.1559 None 0.689 N 0.369 0.154 0.567351761699 gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
I/T 18198 Fn3-20 33 rs745885044 0.9762 -2.196 1.0 N 0.838 0.539 0.749689913766 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/T 18198 Fn3-20 33 rs745885044 0.9762 -2.196 1.0 N 0.838 0.539 0.749689913766 gnomAD-4.0.0 1.59357E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43447E-05 0
I/V 18198 Fn3-20 33 None 0.1271 None 0.993 N 0.373 0.283 0.549755530797 gnomAD-4.0.0 2.73854E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59984E-06 0 0
I/V 18304 Fn3-21 33 rs1011162214 0.1062 None 0.002 N 0.218 0.112 0.355242300401 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 18304 Fn3-21 33 rs1011162214 0.1062 None 0.002 N 0.218 0.112 0.355242300401 gnomAD-4.0.0 1.73747E-05 None None None None N None 0 0 None 0 0 None 0 0 2.37539E-05 0 0
I/F 18511 Fn3-22 33 rs757290658 0.9117 -1.841 1.0 N 0.829 0.537 0.500426043041 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.49E-05 0
I/F 18511 Fn3-22 33 rs757290658 0.9117 -1.841 1.0 N 0.829 0.537 0.500426043041 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/F 18511 Fn3-22 33 rs757290658 0.9117 -1.841 1.0 N 0.829 0.537 0.500426043041 gnomAD-4.0.0 1.31563E-05 None None None None I None 0 0 None 0 0 None 0 0 2.94256E-05 0 0
I/S 18511 Fn3-22 33 rs2053434343 0.9754 None 1.0 D 0.845 0.615 0.895340695038 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
I/S 18511 Fn3-22 33 rs2053434343 0.9754 None 1.0 D 0.845 0.615 0.895340695038 gnomAD-4.0.0 6.58172E-06 None None None None I None 0 6.56168E-05 None 0 0 None 0 0 0 0 0
I/V 18511 Fn3-22 33 None 0.1574 None 0.993 N 0.397 0.234 0.508934680445 gnomAD-4.0.0 1.59287E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43394E-05 0
V/L 18611 Fn3-23 33 None 0.7872 None 0.981 N 0.603 0.234 0.381071309025 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
V/E 18916 Fn3-25 33 rs1296926879 0.9893 -2.344 0.997 N 0.881 0.578 None gnomAD-2.1.1 1.44E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.38E-05 1.42288E-04
V/E 18916 Fn3-25 33 rs1296926879 0.9893 -2.344 0.997 N 0.881 0.578 None gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/E 18916 Fn3-25 33 rs1296926879 0.9893 -2.344 0.997 N 0.881 0.578 None gnomAD-4.0.0 9.30197E-06 None None None None I None 0 1.66967E-05 None 0 0 None 0 0 8.47851E-06 2.1978E-05 3.20431E-05
V/I 19020 Fn3-26 33 None 0.0568 None None N 0.218 0.158 0.220303561663 gnomAD-4.0.0 1.20034E-06 None None None None I None 0 1.01626E-03 None 0 0 None 0 0 0 0 0
I/V 19216 Fn3-27 34 rs374058726 0.077 -1.529 0.006 N 0.24 0.056 None gnomAD-2.1.1 3.64789E-04 None None None None I None 8.52E-05 1.62112E-03 None 0 0 None 0 None 0 2.74079E-04 1.0043E-03
I/V 19216 Fn3-27 34 rs374058726 0.077 -1.529 0.006 N 0.24 0.056 None gnomAD-3.1.2 2.56501E-04 None None None None I None 9.66E-05 6.5505E-04 0 0 0 None 0 0 3.38285E-04 0 9.56938E-04
I/V 19216 Fn3-27 34 rs374058726 0.077 -1.529 0.006 N 0.24 0.056 None gnomAD-4.0.0 3.20132E-04 None None None None I None 6.68199E-05 1.41257E-03 None 0 0 None 1.56794E-05 0 3.47289E-04 2.22936E-05 2.24661E-04
I/V 19316 Fn3-28 33 rs756090879 0.1953 -1.564 0.333 N 0.292 0.114 0.559847471112 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/V 19316 Fn3-28 33 rs756090879 0.1953 -1.564 0.333 N 0.292 0.114 0.559847471112 gnomAD-4.0.0 1.59234E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43365E-05 0
I/T 19512 Fn3-29 34 rs1343150103 0.9518 -2.227 0.822 D 0.807 0.545 0.768437955185 gnomAD-2.1.1 4.04E-06 None None None None I None 0 2.91E-05 None 0 0 None 0 None 0 0 0
I/T 19512 Fn3-29 34 rs1343150103 0.9518 -2.227 0.822 D 0.807 0.545 0.768437955185 gnomAD-4.0.0 1.59241E-06 None None None None I None 0 2.28959E-05 None 0 0 None 0 0 0 0 0
I/M 19610 Fn3-30 32 None 0.5959 None 1.0 D 0.834 0.487 0.518092603711 gnomAD-4.0.0 1.59212E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43324E-05 0
I/F 19712 Fn3-31 33 rs547436872 0.8003 -1.7 1.0 N 0.818 0.546 0.566919426312 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
I/F 19712 Fn3-31 33 rs547436872 0.8003 -1.7 1.0 N 0.818 0.546 0.566919426312 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/F 19712 Fn3-31 33 rs547436872 0.8003 -1.7 1.0 N 0.818 0.546 0.566919426312 gnomAD-4.0.0 8.05745E-06 None None None None N None 0 0 None 0 0 None 0 0 1.10203E-05 0 0
I/L 19712 Fn3-31 33 rs547436872 0.3633 -1.081 0.993 N 0.413 0.346 0.529361283073 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/L 19712 Fn3-31 33 rs547436872 0.3633 -1.081 0.993 N 0.413 0.346 0.529361283073 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
I/L 19712 Fn3-31 33 rs547436872 0.3633 -1.081 0.993 N 0.413 0.346 0.529361283073 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
I/L 19712 Fn3-31 33 rs547436872 0.3633 -1.081 0.993 N 0.413 0.346 0.529361283073 gnomAD-4.0.0 6.84302E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15953E-05 0
I/M 19712 Fn3-31 33 rs928532463 0.5323 -0.927 1.0 D 0.803 0.47 0.467074840246 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/M 19712 Fn3-31 33 rs928532463 0.5323 -0.927 1.0 D 0.803 0.47 0.467074840246 gnomAD-4.0.0 3.18356E-06 None None None None N None 0 2.28728E-05 None 0 2.77562E-05 None 0 0 0 0 0
I/T 19909 Fn3-32 33 rs775088892 0.8843 -2.325 0.201 D 0.789 0.436 0.785508900599 gnomAD-2.1.1 8.1E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.79E-05 0
I/T 19909 Fn3-32 33 rs775088892 0.8843 -2.325 0.201 D 0.789 0.436 0.785508900599 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 19909 Fn3-32 33 rs775088892 0.8843 -2.325 0.201 D 0.789 0.436 0.785508900599 gnomAD-4.0.0 8.06124E-06 None None None None I None 0 0 None 0 0 None 0 0 1.10223E-05 0 0
I/V 19909 Fn3-32 33 rs1060500484 0.0947 -1.56 0.001 N 0.289 0.178 0.252681307341 gnomAD-2.1.1 1.08E-05 None None None None I None 1.24533E-04 0 None 0 0 None 0 None 0 0 0
I/V 19909 Fn3-32 33 rs1060500484 0.0947 -1.56 0.001 N 0.289 0.178 0.252681307341 gnomAD-3.1.2 2.63E-05 None None None None I None 9.65E-05 0 0 0 0 None 0 0 0 0 0
I/V 19909 Fn3-32 33 rs1060500484 0.0947 -1.56 0.001 N 0.289 0.178 0.252681307341 gnomAD-4.0.0 5.58099E-06 None None None None I None 1.06829E-04 0 None 0 0 None 0 0 0 0 1.60277E-05
I/V 20009 Fn3-33 33 rs371988490 0.0925 -1.495 0.993 N 0.392 0.277 None gnomAD-2.1.1 1.43E-05 None None None None I None 1.65344E-04 0 None 0 0 None 0 None 0 0 0
I/V 20009 Fn3-33 33 rs371988490 0.0925 -1.495 0.993 N 0.392 0.277 None gnomAD-3.1.2 5.92E-05 None None None None I None 2.17161E-04 0 0 0 0 None 0 0 0 0 0
I/V 20009 Fn3-33 33 rs371988490 0.0925 -1.495 0.993 N 0.392 0.277 None gnomAD-4.0.0 1.66646E-05 None None None None I None 1.86094E-04 0 None 0 0 None 0 0 4.78826E-06 0 0
I/T 20403 Fn3-36 33 rs757910559 0.9826 -2.068 0.978 N 0.765 0.526 0.710765558589 gnomAD-2.1.1 8.07E-06 None None None None I None 0 5.81E-05 None 0 0 None 0 None 0 0 0
I/T 20403 Fn3-36 33 rs757910559 0.9826 -2.068 0.978 N 0.765 0.526 0.710765558589 gnomAD-4.0.0 1.36898E-06 None None None None I None 0 4.47708E-05 None 0 0 None 0 0 0 0 0
I/V 20403 Fn3-36 33 None 0.1123 None 0.198 N 0.235 0.127 0.407082143382 gnomAD-4.0.0 1.59278E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43419E-05 0
I/L 20601 Fn3-37 33 None 0.6285 None 0.993 N 0.429 0.377 0.621426341079 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/M 20601 Fn3-37 33 rs760014192 0.622 -0.96 1.0 D 0.809 0.487 0.570197126672 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.63E-05 None 0 None 0 0 0
I/M 20601 Fn3-37 33 rs760014192 0.622 -0.96 1.0 D 0.809 0.487 0.570197126672 gnomAD-4.0.0 1.59243E-06 None None None None I None 0 0 None 0 2.78474E-05 None 0 0 0 0 0
N/D 20700 Fn3-38 33 rs151193056 0.8793 -1.167 0.999 N 0.764 0.26 None gnomAD-2.1.1 8.24E-05 None None None None N None 9.50806E-04 0 None 0 0 None 0 None 0 0 0
N/D 20700 Fn3-38 33 rs151193056 0.8793 -1.167 0.999 N 0.764 0.26 None gnomAD-3.1.2 2.23558E-04 None None None None N None 8.20424E-04 0 0 0 0 None 0 0 0 0 0
N/D 20700 Fn3-38 33 rs151193056 0.8793 -1.167 0.999 N 0.764 0.26 None 1000 genomes 5.99042E-04 None None None None N None 2.3E-03 0 None None 0 0 None None None 0 None
N/D 20700 Fn3-38 33 rs151193056 0.8793 -1.167 0.999 N 0.764 0.26 None gnomAD-4.0.0 3.59496E-05 None None None None N None 7.46627E-04 0 None 0 0 None 0 0 0 0 3.20154E-05
N/K 20700 Fn3-38 33 rs997630345 0.9793 -0.273 1.0 N 0.823 0.282 0.242244723065 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
N/K 20700 Fn3-38 33 rs997630345 0.9793 -0.273 1.0 N 0.823 0.282 0.242244723065 gnomAD-4.0.0 3.18449E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72023E-06 0 0
I/M 20896 Fn3-39 33 None 0.6186 None 0.994 D 0.659 0.417 0.614155820699 gnomAD-4.0.0 1.60181E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86022E-06 0 0
I/T 20995 Fn3-40 33 rs1275723419 0.9536 None 0.822 N 0.779 0.492 0.712447893199 gnomAD-4.0.0 1.30036E-05 None None None None N None 0 0 None 0 0 None 0 0 1.70928E-05 0 0
I/V 20995 Fn3-40 33 rs1322917551 0.0877 -1.512 0.006 N 0.241 0.123 0.469333501611 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 6.5189E-04 None 0 None 0 0 0
I/V 20995 Fn3-40 33 rs1322917551 0.0877 -1.512 0.006 N 0.241 0.123 0.469333501611 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93949E-04 None 0 0 0 0 0
I/V 20995 Fn3-40 33 rs1322917551 0.0877 -1.512 0.006 N 0.241 0.123 0.469333501611 gnomAD-4.0.0 6.57661E-06 None None None None N None 0 0 None 0 1.93949E-04 None 0 0 0 0 0
I/N 21096 Fn3-41 33 rs558727238 0.9724 -1.985 0.999 D 0.823 0.55 0.864698151722 gnomAD-2.1.1 1.65271E-04 None None None None I None 0 2.9E-05 None 0 0 None 1.30787E-03 None 0 0 0
I/N 21096 Fn3-41 33 rs558727238 0.9724 -1.985 0.999 D 0.823 0.55 0.864698151722 gnomAD-3.1.2 4.6E-05 None None None None I None 0 0 0 0 0 None 0 0 0 1.45108E-03 0
I/N 21096 Fn3-41 33 rs558727238 0.9724 -1.985 0.999 D 0.823 0.55 0.864698151722 1000 genomes 3.99361E-04 None None None None I None 0 0 None None 0 0 None None None 2E-03 None
I/N 21096 Fn3-41 33 rs558727238 0.9724 -1.985 0.999 D 0.823 0.55 0.864698151722 gnomAD-4.0.0 7.37809E-05 None None None None I None 0 3.33611E-05 None 0 0 None 0 0 8.47968E-07 1.24154E-03 4.80492E-05
I/V 21096 Fn3-41 33 rs568922646 0.0893 -1.483 0.198 N 0.249 0.122 0.474564258015 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/V 21096 Fn3-41 33 rs568922646 0.0893 -1.483 0.198 N 0.249 0.122 0.474564258015 gnomAD-3.1.2 1.32E-05 None None None None I None 2.41E-05 6.56E-05 0 0 0 None 0 0 0 0 0
I/V 21096 Fn3-41 33 rs568922646 0.0893 -1.483 0.198 N 0.249 0.122 0.474564258015 1000 genomes 1.99681E-04 None None None None I None 0 1.4E-03 None None 0 0 None None None 0 None
I/V 21096 Fn3-41 33 rs568922646 0.0893 -1.483 0.198 N 0.249 0.122 0.474564258015 gnomAD-4.0.0 1.31422E-05 None None None None I None 2.40535E-05 6.54707E-05 None 0 0 None 0 0 0 0 0
V/M 21298 Fn3-42 33 rs1236931080 0.5112 -0.511 0.997 N 0.717 0.379 0.614204031915 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
V/M 21298 Fn3-42 33 rs1236931080 0.5112 -0.511 0.997 N 0.717 0.379 0.614204031915 gnomAD-4.0.0 2.73829E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69918E-06 0 1.65799E-05
I/S 21398 Fn3-43 33 rs727504754 0.977 -2.171 0.942 D 0.765 0.52 0.8006517185 gnomAD-2.1.1 3.22E-05 None None None None I None 0 0 None 0 0 None 2.61455E-04 None 0 0 0
I/S 21398 Fn3-43 33 rs727504754 0.977 -2.171 0.942 D 0.765 0.52 0.8006517185 gnomAD-4.0.0 1.75201E-05 None None None None I None 0 0 None 0 0 None 0 0 0 1.57652E-04 0
I/F 21592 Fn3-44 34 rs727503581 0.9515 -1.891 0.942 D 0.719 0.409 0.681350956159 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
I/F 21592 Fn3-44 34 rs727503581 0.9515 -1.891 0.942 D 0.719 0.409 0.681350956159 gnomAD-4.0.0 6.84358E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99619E-07 0 0
I/N 21592 Fn3-44 34 None 0.9797 None 0.99 D 0.839 0.534 0.891053409257 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
I/V 21592 Fn3-44 34 rs727503581 0.1416 -1.625 0.006 N 0.233 0.161 0.448696893172 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 1.30719E-04 None 0 0 0
I/V 21592 Fn3-44 34 rs727503581 0.1416 -1.625 0.006 N 0.233 0.161 0.448696893172 gnomAD-4.0.0 8.21229E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.3914E-04 0
I/N 21691 Fn3-45 33 None 0.9228 -1.782 0.998 D 0.839 0.519 0.86998522814 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/N 21691 Fn3-45 33 None 0.9228 -1.782 0.998 D 0.839 0.519 0.86998522814 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/N 21691 Fn3-45 33 None 0.9228 -1.782 0.998 D 0.839 0.519 0.86998522814 gnomAD-4.0.0 5.5791E-06 None None None None I None 0 1.66789E-05 None 0 0 None 0 0 6.78235E-06 0 0
I/T 21789 Fn3-46 33 rs2048319290 0.9487 None 0.684 D 0.795 0.474 0.707130027437 gnomAD-4.0.0 1.12037E-05 None None None None N None 0 0 None 0 0 None 0 0 2.00997E-05 0 0
I/V 21789 Fn3-46 33 None 0.1912 None 0.003 N 0.227 0.09 0.524166996187 gnomAD-4.0.0 1.60089E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87223E-06 0 0
I/L 21988 Fn3-47 33 None 0.6552 None 0.993 N 0.405 0.394 0.670927618927 gnomAD-4.0.0 1.5932E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86157E-06 0 0
I/T 21988 Fn3-47 33 rs776884578 0.9771 -1.866 1.0 D 0.825 0.591 0.787357044059 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 9.81E-05 None 0 0 0
I/T 21988 Fn3-47 33 rs776884578 0.9771 -1.866 1.0 D 0.825 0.591 0.787357044059 gnomAD-4.0.0 7.53029E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.27607E-04 0
I/V 22087 Fn3-48 33 None 0.0942 None 0.993 D 0.377 0.267 0.59450981025 gnomAD-4.0.0 1.59318E-06 None None None None I None 5.6638E-05 0 None 0 0 None 0 0 0 0 0
I/V 22483 Fn3-51 33 rs1291879446 0.1747 -1.522 0.198 N 0.251 0.125 0.471211772063 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/V 22483 Fn3-51 33 rs1291879446 0.1747 -1.522 0.198 N 0.251 0.125 0.471211772063 gnomAD-4.0.0 1.59227E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
I/N 22676 Fn3-52 34 None 0.9673 None 0.99 N 0.837 0.585 0.852610865174 gnomAD-4.0.0 1.59246E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86018E-06 0 0
I/T 22775 Fn3-53 33 None 0.9488 None 1.0 N 0.829 0.55 0.732322575749 gnomAD-4.0.0 2.40418E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62883E-06 0 0
I/V 22775 Fn3-53 33 rs768713071 0.0854 -1.367 0.993 N 0.391 0.278 0.529661991002 gnomAD-2.1.1 8.16E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.8E-05 0
I/V 22775 Fn3-53 33 rs768713071 0.0854 -1.367 0.993 N 0.391 0.278 0.529661991002 gnomAD-3.1.2 1.97E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 22775 Fn3-53 33 rs768713071 0.0854 -1.367 0.993 N 0.391 0.278 0.529661991002 gnomAD-4.0.0 6.83411E-06 None None None None I None 2.67415E-05 0 None 0 0 None 0 0 7.64353E-06 0 0
I/M 23072 Fn3-55 33 rs374117511 0.466 -0.843 0.991 D 0.727 0.41 None gnomAD-2.1.1 5.24E-05 None None None None I None 0 0 None 0 0 None 0 None 0 1.15842E-04 0
I/M 23072 Fn3-55 33 rs374117511 0.466 -0.843 0.991 D 0.727 0.41 None gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/M 23072 Fn3-55 33 rs374117511 0.466 -0.843 0.991 D 0.727 0.41 None gnomAD-4.0.0 3.46172E-05 None None None None I None 0 0 None 0 0 None 0 0 5.50711E-05 1.34077E-05 8.53777E-05
I/N 23072 Fn3-55 33 rs1309205725 0.969 -1.646 0.997 D 0.819 0.578 0.897848762137 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14837E-04 0 None 0 0 None 0 None 0 0 0
I/N 23072 Fn3-55 33 rs1309205725 0.969 -1.646 0.997 D 0.819 0.578 0.897848762137 gnomAD-3.1.2 1.32E-05 None None None None I None 2.42E-05 0 0 0 0 None 0 0 1.47E-05 0 0
I/N 23072 Fn3-55 33 rs1309205725 0.969 -1.646 0.997 D 0.819 0.578 0.897848762137 gnomAD-4.0.0 7.43903E-06 None None None None I None 1.33608E-05 0 None 0 0 None 0 0 9.32575E-06 0 0
I/V 23072 Fn3-55 33 rs2046609808 0.0698 None 0.02 N 0.244 0.112 0.433491693731 gnomAD-4.0.0 3.18451E-06 None None None None I None 0 2.28676E-05 None 0 0 None 0 0 2.86E-06 0 0
I/S 23272 Fn3-57 33 rs758398301 0.9731 -2.705 0.994 N 0.829 0.567 0.798838478998 gnomAD-2.1.1 9.61E-06 None None None None I None 0 0 None 0 0 None 0 None 0 2.05E-05 0
I/S 23272 Fn3-57 33 rs758398301 0.9731 -2.705 0.994 N 0.829 0.567 0.798838478998 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/S 23272 Fn3-57 33 rs758398301 0.9731 -2.705 0.994 N 0.829 0.567 0.798838478998 gnomAD-4.0.0 9.53922E-06 None None None None I None 0 0 None 0 0 None 0 1.71762E-04 1.11732E-05 0 1.64929E-05
I/M 23467 Fn3-58 33 None 0.6591 None 0.95 D 0.706 0.408 0.618565862433 gnomAD-4.0.0 1.59181E-06 None None None None I None 0 0 None 0 0 None 1.88253E-05 0 0 0 0
I/T 23467 Fn3-58 33 rs778170654 0.9694 -2.389 0.87 N 0.796 0.497 0.765417107005 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
I/V 23467 Fn3-58 33 rs866974760 0.1068 None 0.001 N 0.253 0.079 0.369682402691 gnomAD-4.0.0 2.05293E-06 None None None None I None 0 0 None 0 0 None 0 3.47102E-04 0 0 1.65695E-05
I/F 23564 Fn3-59 33 None 0.9279 None 1.0 D 0.833 0.543 0.654604268507 gnomAD-4.0.0 1.5917E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85927E-06 0 0
I/L 23759 Fn3-60 34 None 0.3325 None 0.426 N 0.406 0.212 0.477065420593 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 23759 Fn3-60 34 rs751178599 0.0899 -1.447 0.011 N 0.223 0.118 0.415947407303 gnomAD-2.1.1 4.05E-06 None None None None I None 0 2.91E-05 None 0 0 None 0 None 0 0 0
I/V 23858 Fn3-61 33 rs1401908315 0.0723 None 0.02 N 0.249 0.137 0.456183601318 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 23858 Fn3-61 33 rs1401908315 0.0723 None 0.02 N 0.249 0.137 0.456183601318 gnomAD-4.0.0 6.57376E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47063E-05 0 0
I/M 23956 Fn3-62 33 rs778594459 0.2693 -0.912 1.0 D 0.809 0.428 0.640559690875 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.62E-05 None 0 None 0 0 0
I/T 24155 Fn3-63 34 rs946539839 0.5572 None 1.0 D 0.84 0.556 0.765966819243 gnomAD-4.0.0 2.93253E-06 None None None None I None 0 0 None 0 0 None 0 0 3.75184E-06 0 0
I/N 24254 Fn3-64 33 None 0.9461 None 0.999 D 0.839 0.542 0.896069202243 gnomAD-4.0.0 1.85578E-06 None None None None I None 0 0 None 0 0 None 0 2.69687E-04 0 0 0
I/V 24254 Fn3-64 33 None 0.1546 None 0.889 N 0.472 0.171 0.50055108712 gnomAD-4.0.0 1.85602E-06 None None None None I None 0 0 None 0 0 None 0 0 3.25837E-06 0 0
I/V 24551 Fn3-66 33 rs879246805 0.1174 -1.647 0.05 N 0.257 0.098 None gnomAD-2.1.1 1.79E-05 None None None None I None 2.06765E-04 0 None 0 0 None 0 None 0 0 0
I/V 24551 Fn3-66 33 rs879246805 0.1174 -1.647 0.05 N 0.257 0.098 None gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
I/V 24551 Fn3-66 33 rs879246805 0.1174 -1.647 0.05 N 0.257 0.098 None gnomAD-4.0.0 8.97714E-06 None None None None I None 1.01588E-04 0 None 0 0 None 0 0 0 1.34084E-05 0
I/T 24841 Fn3-68 34 rs1382387828 0.947 None 0.892 D 0.781 0.5 0.728227171412 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 24940 Fn3-69 33 None 0.8649 None 0.296 N 0.667 0.358 0.59385865776 gnomAD-4.0.0 6.84322E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99596E-07 0 0
V/D 24940 Fn3-69 33 rs754897261 0.9759 -1.773 0.879 N 0.812 0.468 0.803159424316 gnomAD-2.1.1 2.82E-05 None None None None I None 0 0 None 0 0 None 2.28788E-04 None 0 0 0
V/D 24940 Fn3-69 33 rs754897261 0.9759 -1.773 0.879 N 0.812 0.468 0.803159424316 gnomAD-4.0.0 1.09492E-05 None None None None I None 0 0 None 0 0 None 0 0 0 1.85503E-04 0
V/I 24940 Fn3-69 33 None 0.068 None 0.001 N 0.249 0.071 0.245660935333 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62502E-06 0 0
I/S 25038 Fn3-70 33 None 0.9615 None 0.942 D 0.817 0.53 0.813462614861 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
I/V 25038 Fn3-70 33 None 0.1063 None 0.006 N 0.261 0.078 0.41219620536 gnomAD-4.0.0 1.36931E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.31943E-05 0
I/N 25237 Fn3-71 34 rs756017651 0.924 -1.995 0.998 D 0.849 0.562 0.845632121002 gnomAD-2.1.1 1.62E-05 None None None None I None 0 0 None 0 0 None 6.54E-05 None 4.65E-05 8.96E-06 0
I/N 25237 Fn3-71 34 rs756017651 0.924 -1.995 0.998 D 0.849 0.562 0.845632121002 gnomAD-4.0.0 6.37048E-06 None None None None I None 0 0 None 0 0 None 1.88686E-05 0 0 2.86582E-05 3.02718E-05
I/T 25237 Fn3-71 34 rs756017651 0.8549 -2.42 0.961 D 0.726 0.5 0.725541513621 gnomAD-2.1.1 4.04E-06 None None None None I None 6.49E-05 0 None 0 0 None 0 None 0 0 0
I/T 25237 Fn3-71 34 rs756017651 0.8549 -2.42 0.961 D 0.726 0.5 0.725541513621 gnomAD-4.0.0 1.59262E-06 None None None None I None 5.66251E-05 0 None 0 0 None 0 0 0 0 0
I/V 25237 Fn3-71 34 rs1412324143 0.0919 -1.67 0.122 N 0.211 0.071 0.563099480232 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 4.65E-05 0 0
I/V 25237 Fn3-71 34 rs1412324143 0.0919 -1.67 0.122 N 0.211 0.071 0.563099480232 gnomAD-4.0.0 1.36891E-06 None None None None I None 0 0 None 0 0 None 1.87688E-05 0 8.99607E-07 0 0
I/T 25336 Fn3-72 33 rs1707608600 0.9696 None 1.0 D 0.858 0.562 0.756051586483 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
I/T 25336 Fn3-72 33 rs1707608600 0.9696 None 1.0 D 0.858 0.562 0.756051586483 gnomAD-4.0.0 2.56322E-06 None None None None I None 0 3.39109E-05 None 0 0 None 0 0 0 0 0
I/V 25633 Fn3-74 33 None 0.1186 None 0.05 N 0.253 0.117 0.523650220922 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/F 25730 Fn3-75 33 None 0.9502 None 0.999 N 0.739 0.518 0.720195407567 gnomAD-4.0.0 1.36869E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79919E-06 0 0
I/V 25730 Fn3-75 33 rs745981754 0.1314 -1.542 0.088 N 0.239 0.112 0.491660673884 gnomAD-2.1.1 2.41E-05 None None None None N None 0 1.44852E-04 None 0 0 None 0 None 0 8.89E-06 0
I/V 25730 Fn3-75 33 rs745981754 0.1314 -1.542 0.088 N 0.239 0.112 0.491660673884 gnomAD-3.1.2 1.32E-05 None None None None N None 0 1.31216E-04 0 0 0 None 0 0 0 0 0
I/V 25730 Fn3-75 33 rs745981754 0.1314 -1.542 0.088 N 0.239 0.112 0.491660673884 gnomAD-4.0.0 9.29762E-06 None None None None N None 0 1.8345E-04 None 0 0 None 0 1.64582E-04 2.54326E-06 0 0
I/M 25923 Fn3-76 34 rs780766847 0.5648 -1.016 1.0 N 0.831 0.43 0.479133204078 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/M 25923 Fn3-76 34 rs780766847 0.5648 -1.016 1.0 N 0.831 0.43 0.479133204078 gnomAD-4.0.0 6.84418E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.1595E-05 0
I/T 25923 Fn3-76 34 rs1706767916 0.9655 None 1.0 D 0.854 0.585 0.758052853744 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/T 25923 Fn3-76 34 rs1706767916 0.9655 None 1.0 D 0.854 0.585 0.758052853744 gnomAD-4.0.0 6.5741E-06 None None None None I None 2.41266E-05 0 None 0 0 None 0 0 0 0 0
V/D 26022 Fn3-77 33 rs562356397 0.9888 -1.39 0.667 D 0.847 0.525 0.779176552023 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 9.81E-05 None 0 0 0
V/D 26022 Fn3-77 33 rs562356397 0.9888 -1.39 0.667 D 0.847 0.525 0.779176552023 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
V/D 26022 Fn3-77 33 rs562356397 0.9888 -1.39 0.667 D 0.847 0.525 0.779176552023 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
V/D 26022 Fn3-77 33 rs562356397 0.9888 -1.39 0.667 D 0.847 0.525 0.779176552023 gnomAD-4.0.0 2.47925E-06 None None None None I None 0 0 None 0 0 None 0 0 0 4.39194E-05 0
V/G 26022 Fn3-77 33 None 0.9424 None 0.667 N 0.841 0.509 0.744392159427 gnomAD-4.0.0 2.05312E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69882E-06 0 0
V/I 26022 Fn3-77 33 rs374764110 0.0647 -0.586 0.002 N 0.223 0.054 None gnomAD-2.1.1 8.96E-05 None None None None I None 4.96196E-04 2.84E-05 None 0 0 None 0 None 0 8.64E-05 1.41203E-04
V/I 26022 Fn3-77 33 rs374764110 0.0647 -0.586 0.002 N 0.223 0.054 None gnomAD-3.1.2 1.84143E-04 None None None None I None 5.79514E-04 0 0 0 0 None 0 0 5.88E-05 0 0
V/I 26022 Fn3-77 33 rs374764110 0.0647 -0.586 0.002 N 0.223 0.054 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
V/I 26022 Fn3-77 33 rs374764110 0.0647 -0.586 0.002 N 0.223 0.054 None gnomAD-4.0.0 5.45456E-05 None None None None I None 5.20097E-04 1.66783E-05 None 0 0 None 0 1.65235E-04 3.56067E-05 1.09798E-05 6.40677E-05
V/L 26022 Fn3-77 33 rs374764110 0.3786 None 0.022 N 0.44 0.116 0.326881540566 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 6.32911E-03 0 0 0
V/L 26022 Fn3-77 33 rs374764110 0.3786 None 0.022 N 0.44 0.116 0.326881540566 gnomAD-4.0.0 1.31428E-05 None None None None I None 0 0 None 0 0 None 0 6.80272E-03 0 0 0
I/F 26120 Fn3-78 33 None 0.9137 None 0.994 D 0.669 0.427 0.684186827415 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/N 26319 Fn3-79 34 None 0.9747 None 0.999 D 0.845 0.603 0.862726850884 gnomAD-4.0.0 6.84407E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99688E-07 0 0
I/T 26319 Fn3-79 34 rs1706219374 0.9145 None 0.989 D 0.786 0.574 0.726705045765 gnomAD-4.0.0 2.05322E-06 None None None None I None 0 6.71111E-05 None 0 0 None 0 0 0 0 0
I/V 26418 Fn3-80 33 rs1382272786 0.1598 -1.613 0.993 N 0.387 0.269 0.599423059063 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.59E-05 None 0 None 0 0 0
I/V 26418 Fn3-80 33 rs1382272786 0.1598 -1.613 0.993 N 0.387 0.269 0.599423059063 gnomAD-4.0.0 1.3686E-06 None None None None I None 0 0 None 0 5.04414E-05 None 0 0 0 0 0
V/F 26715 Fn3-82 33 rs1705694653 0.8406 None 0.317 N 0.733 0.289 0.511503663882 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.93349E-04 None 0 0 0 0 0
V/F 26715 Fn3-82 33 rs1705694653 0.8406 None 0.317 N 0.733 0.289 0.511503663882 gnomAD-4.0.0 2.56306E-06 None None None None I None 0 0 None 0 2.42624E-05 None 0 0 0 0 2.84576E-05
V/I 26812 Fn3-83 33 None 0.0541 None None N 0.13 0.177 0.126345400529 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 6.17284E-04 0 0 0
I/K 27005 Fn3-84 34 rs1430969967 0.9902 -1.744 0.983 D 0.842 0.666 0.87933222287 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 4.65E-05 0 0
I/T 27005 Fn3-84 34 rs1430969967 0.9397 -2.12 0.892 D 0.794 0.61 0.749266289315 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
I/T 27005 Fn3-84 34 rs1430969967 0.9397 -2.12 0.892 D 0.794 0.61 0.749266289315 gnomAD-4.0.0 2.05299E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69879E-06 0 0
I/T 27402 Fn3-87 34 rs1440068759 0.8762 -1.979 0.967 N 0.785 0.527 0.801486161926 gnomAD-2.1.1 8.05E-06 None None None None I None 0 5.8E-05 None 0 0 None 0 None 0 0 0
I/T 27402 Fn3-87 34 rs1440068759 0.8762 -1.979 0.967 N 0.785 0.527 0.801486161926 gnomAD-3.1.2 1.97E-05 None None None None I None 0 1.31113E-04 0 0 0 None 0 0 0 0 4.78469E-04
I/T 27402 Fn3-87 34 rs1440068759 0.8762 -1.979 0.967 N 0.785 0.527 0.801486161926 gnomAD-4.0.0 1.15314E-05 None None None None I None 1.69153E-05 8.47659E-05 None 0 0 None 0 0 0 0 8.53291E-05
I/V 27402 Fn3-87 34 rs1321218622 0.0997 -1.559 0.426 N 0.448 0.196 0.535679682109 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.58E-05 None 0 None 0 0 0
I/M 27501 Fn3-88 33 rs768922879 0.299 -1.12 0.998 D 0.705 0.461 0.505765104075 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
I/M 27501 Fn3-88 33 rs768922879 0.299 -1.12 0.998 D 0.705 0.461 0.505765104075 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.93798E-04 None 0 0 0 0 0
I/M 27501 Fn3-88 33 rs768922879 0.299 -1.12 0.998 D 0.705 0.461 0.505765104075 gnomAD-4.0.0 6.5786E-06 None None None None I None 0 0 None 0 1.93798E-04 None 0 0 0 0 0
I/T 27501 Fn3-88 33 None 0.5806 None 0.989 D 0.783 0.56 0.729170019825 gnomAD-4.0.0 1.59124E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85838E-06 0 0
V/L 27602 Fn3-89 33 rs886038821 0.3032 None None N 0.245 0.094 0.226586394389 gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
V/L 27602 Fn3-89 33 rs886038821 0.3032 None None N 0.245 0.094 0.226586394389 gnomAD-4.0.0 5.12538E-06 None None None None I None 5.07477E-05 0 None 0 0 None 0 0 2.39331E-06 0 0
I/N 27798 Fn3-90 33 None 0.9483 None 0.999 D 0.815 0.634 0.886518283301 gnomAD-4.0.0 1.60035E-06 None None None None I None 0 0 None 0 0 None 0 0 2.87358E-06 0 0
I/T 27798 Fn3-90 33 None 0.9543 None 0.925 N 0.75 0.573 0.767795433346 gnomAD-4.0.0 1.60035E-06 None None None None I None 0 0 None 0 0 None 0 0 2.87358E-06 0 0
V/L 28186 Fn3-93 33 None 0.579 None 0.369 N 0.511 0.146 0.476908202251 gnomAD-4.0.0 1.59267E-06 None None None None I None 0 0 None 0 0 None 0 2.41663E-04 0 0 0
I/T 28284 Fn3-94 33 rs1462392007 0.9332 None 0.896 N 0.724 0.53 0.72338399144 gnomAD-4.0.0 1.59128E-06 None None None None N None 5.65419E-05 0 None 0 0 None 0 0 0 0 0
I/V 28284 Fn3-94 33 rs1408628454 0.1279 None 0.004 N 0.181 0.127 0.416075642716 gnomAD-4.0.0 3.18249E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71611E-06 0 0
I/V 28483 Fn3-95 34 None 0.0859 None 0.003 N 0.179 0.124 0.419461527279 gnomAD-4.0.0 1.59159E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
I/K 28582 Fn3-96 33 rs201688358 0.9807 -1.782 1.0 D 0.887 0.642 None gnomAD-2.1.1 3.57E-05 None None None None I None 4.1336E-04 0 None 0 0 None 0 None 0 0 0
I/K 28582 Fn3-96 33 rs201688358 0.9807 -1.782 1.0 D 0.887 0.642 None gnomAD-3.1.2 1.24961E-04 None None None None I None 4.5907E-04 0 0 0 0 None 0 0 0 0 0
I/K 28582 Fn3-96 33 rs201688358 0.9807 -1.782 1.0 D 0.887 0.642 None gnomAD-4.0.0 1.85931E-05 None None None None I None 3.8741E-04 0 None 0 0 None 0 0 0 0 1.60149E-05
I/T 28582 Fn3-96 33 None 0.938 None 1.0 D 0.857 0.582 0.765291902356 gnomAD-4.0.0 6.84252E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99463E-07 0 0
I/T 28683 Fn3-97 33 rs1482174421 0.8356 None 0.062 N 0.655 0.384 0.676853945565 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/T 28683 Fn3-97 33 rs1482174421 0.8356 None 0.062 N 0.655 0.384 0.676853945565 gnomAD-4.0.0 6.57592E-06 None None None None I None 2.41406E-05 0 None 0 0 None 0 0 0 0 0
I/V 28683 Fn3-97 33 rs1179601203 0.0566 -1.599 None N 0.136 0.195 0.185906805712 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.97E-06 0
V/G 28877 Fn3-98 33 None 0.9487 None 1.0 N 0.859 0.588 0.903930641201 gnomAD-4.0.0 1.59145E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85881E-06 0 0
V/L 28877 Fn3-98 33 rs750357355 0.5824 -0.737 0.997 N 0.704 0.349 0.399017061211 gnomAD-2.1.1 3.18E-05 None None None None I None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
V/L 28877 Fn3-98 33 rs750357355 0.5824 -0.737 0.997 N 0.704 0.349 0.399017061211 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/L 28877 Fn3-98 33 rs750357355 0.5824 -0.737 0.997 N 0.704 0.349 0.399017061211 gnomAD-4.0.0 1.85914E-06 None None None None I None 4.00427E-05 0 None 0 0 None 0 0 0 0 0
V/M 28877 Fn3-98 33 rs750357355 0.6804 -0.59 1.0 N 0.813 0.408 0.497086342495 gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
V/M 28877 Fn3-98 33 rs750357355 0.6804 -0.59 1.0 N 0.813 0.408 0.497086342495 gnomAD-4.0.0 3.42119E-06 None None None None I None 0 0 None 0 0 None 0 0 0 5.79737E-05 0
I/T 28974 Fn3-99 33 rs762434090 0.604 -2.484 0.732 N 0.764 0.516 0.789066735824 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
I/T 28974 Fn3-99 33 rs762434090 0.604 -2.484 0.732 N 0.764 0.516 0.789066735824 gnomAD-4.0.0 4.10538E-06 None None None None I None 2.98739E-05 0 None 0 0 None 0 0 2.69836E-06 2.31879E-05 0
V/A 29269 Fn3-101 33 None 0.7311 None 0.977 N 0.662 0.466 0.634567249438 gnomAD-4.0.0 1.36834E-06 None None None None I None 5.97372E-05 0 None 0 0 None 0 0 0 0 0
V/I 29269 Fn3-101 33 rs727503551 0.0758 -0.726 0.117 N 0.337 0.074 0.422404719673 gnomAD-2.1.1 3.22E-05 None None None None I None 0 2.9E-05 None 0 0 None 9.8E-05 None 0 3.55E-05 0
V/I 29269 Fn3-101 33 rs727503551 0.0758 -0.726 0.117 N 0.337 0.074 0.422404719673 gnomAD-3.1.2 3.28E-05 None None None None I None 0 0 0 0 0 None 0 6.32911E-03 4.41E-05 0 0
V/I 29269 Fn3-101 33 rs727503551 0.0758 -0.726 0.117 N 0.337 0.074 0.422404719673 gnomAD-4.0.0 2.97405E-05 None None None None I None 0 1.66594E-05 None 0 0 None 0 1.48515E-03 2.45791E-05 5.48932E-05 6.40164E-05
I/T 29367 Fn3-102 33 rs778882176 0.9486 -2.159 0.722 D 0.812 0.472 0.714733430009 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
I/T 29367 Fn3-102 33 rs778882176 0.9486 -2.159 0.722 D 0.812 0.472 0.714733430009 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 29367 Fn3-102 33 rs778882176 0.9486 -2.159 0.722 D 0.812 0.472 0.714733430009 gnomAD-4.0.0 5.12464E-06 None None None None I None 0 0 None 0 0 None 0 0 7.17817E-06 0 2.84398E-05
I/L 29566 Fn3-103 34 rs1700639038 0.3623 None 0.19 N 0.319 0.134 0.522397993787 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/L 29566 Fn3-103 34 rs1700639038 0.3623 None 0.19 N 0.319 0.134 0.522397993787 gnomAD-4.0.0 3.09829E-06 None None None None N None 0 0 None 0 2.22856E-05 None 0 0 3.39026E-06 0 0
I/V 29566 Fn3-103 34 None 0.1018 None 0.001 N 0.138 0.103 0.418344901717 gnomAD-4.0.0 6.84167E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99421E-07 0 0
I/L 29665 Fn3-104 33 None 0.294 None 0.043 N 0.415 0.166 0.235664433957 gnomAD-4.0.0 6.84187E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99446E-07 0 0
I/R 29665 Fn3-104 33 None 0.9574 None 0.781 D 0.837 0.545 0.841281731114 gnomAD-4.0.0 1.20033E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
I/V 29665 Fn3-104 33 rs1700376721 0.0753 None 0.001 N 0.252 0.082 0.230578612272 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.06697E-04 0
I/V 29665 Fn3-104 33 rs1700376721 0.0753 None 0.001 N 0.252 0.082 0.230578612272 gnomAD-4.0.0 3.09832E-06 None None None None I None 0 0 None 0 0 None 0 0 2.54275E-06 2.19553E-05 0
V/F 29766 Fn3-105 33 rs780822733 0.825 -1.474 0.497 N 0.783 0.221 0.563619085548 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
V/L 29766 Fn3-105 33 rs780822733 0.4427 -0.702 0.009 N 0.427 0.047 0.361360026772 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
V/L 29766 Fn3-105 33 rs780822733 0.4427 -0.702 0.009 N 0.427 0.047 0.361360026772 gnomAD-4.0.0 8.895E-06 None None None None I None 0 0 None 0 0 None 0 0 1.16933E-05 0 0
I/K 29965 Fn3-106 33 None 0.9807 None 0.984 D 0.797 0.584 0.874136450708 gnomAD-4.0.0 1.59642E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43291E-05 0
I/T 29965 Fn3-106 33 rs1409848812 0.9112 None 0.896 N 0.649 0.483 0.748136256137 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
I/T 29965 Fn3-106 33 rs1409848812 0.9112 None 0.896 N 0.649 0.483 0.748136256137 gnomAD-4.0.0 6.57065E-06 None None None None I None 0 6.54879E-05 None 0 0 None 0 0 0 0 0
I/V 29965 Fn3-106 33 rs370135800 0.0706 -1.596 0.004 N 0.14 0.079 None gnomAD-2.1.1 1.22E-05 None None None None I None 6.46E-05 0 None 0 1.11995E-04 None 0 None 0 0 0
I/V 29965 Fn3-106 33 rs370135800 0.0706 -1.596 0.004 N 0.14 0.079 None gnomAD-3.1.2 2.63E-05 None None None None I None 9.65E-05 0 0 0 0 None 0 0 0 0 0
I/V 29965 Fn3-106 33 rs370135800 0.0706 -1.596 0.004 N 0.14 0.079 None gnomAD-4.0.0 4.34328E-06 None None None None I None 6.67183E-05 0 None 0 2.23085E-05 None 0 0 0 0 1.60164E-05
I/F 30062 Fn3-107 33 rs931535269 0.8459 -1.72 0.991 D 0.755 0.428 0.704837425536 gnomAD-2.1.1 1.07E-05 None None None None I None 1.23957E-04 0 None 0 0 None 0 None 0 0 0
I/F 30062 Fn3-107 33 rs931535269 0.8459 -1.72 0.991 D 0.755 0.428 0.704837425536 gnomAD-3.1.2 5.91E-05 None None None None I None 1.92911E-04 0 0 0 0 None 0 0 0 0 4.78011E-04
I/F 30062 Fn3-107 33 rs931535269 0.8459 -1.72 0.991 D 0.755 0.428 0.704837425536 gnomAD-4.0.0 1.28084E-05 None None None None I None 1.5213E-04 0 None 0 0 None 0 0 0 0 2.84398E-05
I/T 30062 Fn3-107 33 rs773537655 0.8724 -2.379 0.939 N 0.755 0.482 0.779659085684 gnomAD-2.1.1 7.13E-06 None None None None I None 8.27E-05 0 None 0 0 None 0 None 0 0 0
I/T 30062 Fn3-107 33 rs773537655 0.8724 -2.379 0.939 N 0.755 0.482 0.779659085684 gnomAD-3.1.2 1.31E-05 None None None None I None 4.82E-05 0 0 0 0 None 0 0 0 0 0
I/T 30062 Fn3-107 33 rs773537655 0.8724 -2.379 0.939 N 0.755 0.482 0.779659085684 gnomAD-4.0.0 3.09824E-06 None None None None I None 4.00384E-05 0 None 0 0 None 0 0 1.69515E-06 0 0
I/V 30062 Fn3-107 33 rs931535269 0.1252 None 0.02 N 0.261 0.169 0.480198768302 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.54E-05 0 0 0 None 0 0 0 0 0
I/V 30062 Fn3-107 33 rs931535269 0.1252 None 0.02 N 0.261 0.169 0.480198768302 gnomAD-4.0.0 6.56944E-06 None None None None I None 0 6.54365E-05 None 0 0 None 0 0 0 0 0
I/V 30257 Fn3-108 34 None 0.1458 None 0.993 N 0.385 0.274 0.620317764101 gnomAD-4.0.0 1.59132E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85822E-06 0 0
V/A 30356 Fn3-109 33 rs780689608 0.7988 -1.319 0.78 N 0.655 0.408 0.555237559564 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
V/A 30356 Fn3-109 33 rs780689608 0.7988 -1.319 0.78 N 0.655 0.408 0.555237559564 gnomAD-4.0.0 1.59111E-06 None None None None I None 0 0 None 0 2.77285E-05 None 0 0 0 0 0
V/I 30356 Fn3-109 33 rs752225531 0.064 -0.627 0.011 N 0.225 0.079 0.237489013734 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
V/I 30356 Fn3-109 33 rs752225531 0.064 -0.627 0.011 N 0.225 0.079 0.237489013734 gnomAD-4.0.0 1.59111E-06 None None None None I None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
I/L 30454 Fn3-110 33 None 0.3362 None 0.294 N 0.417 0.253 0.29385284311 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/T 30454 Fn3-110 33 rs878985220 0.8686 -2.073 0.822 N 0.763 0.515 0.625654597223 gnomAD-2.1.1 7.14E-06 None None None None I None 8.27E-05 0 None 0 0 None 0 None 0 0 0
I/T 30454 Fn3-110 33 rs878985220 0.8686 -2.073 0.822 N 0.763 0.515 0.625654597223 gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
I/T 30454 Fn3-110 33 rs878985220 0.8686 -2.073 0.822 N 0.763 0.515 0.625654597223 gnomAD-4.0.0 1.98348E-05 None None None None I None 6.68163E-05 0 None 0 0 None 0 0 2.1193E-05 0 3.20266E-05
I/M 30751 Fn3-112 33 None 0.5623 None 1.0 D 0.832 0.428 0.614131634805 gnomAD-4.0.0 1.59125E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8582E-06 0 0
I/F 31048 Fn3-114 33 None 0.8708 None 0.942 D 0.745 0.426 0.463758542814 gnomAD-4.0.0 6.84184E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99449E-07 0 0
I/V 31048 Fn3-114 33 None 0.1188 None 0.006 N 0.243 0.084 0.507331908393 gnomAD-4.0.0 6.84184E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99449E-07 0 0
I/M 31341 Fn3-116 34 None 0.3325 None 1.0 D 0.817 0.493 0.505885190548 gnomAD-4.0.0 1.59112E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85801E-06 0 0
V/I 31538 Fn3-118 33 rs1389165052 0.0706 None None N 0.252 0.076 0.212008924253 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 31538 Fn3-118 33 rs1389165052 0.0706 None None N 0.252 0.076 0.212008924253 gnomAD-4.0.0 1.24083E-06 None None None None I None 0 0 None 0 0 None 0 0 8.48692E-07 0 1.60426E-05
I/T 31740 Fn3-119 33 rs200781956 0.8765 -2.375 0.062 D 0.711 0.473 None gnomAD-2.1.1 8.05E-06 None None None None I None 1.29199E-04 0 None 0 0 None 0 None 0 0 0
I/T 31740 Fn3-119 33 rs200781956 0.8765 -2.375 0.062 D 0.711 0.473 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/T 31740 Fn3-119 33 rs200781956 0.8765 -2.375 0.062 D 0.711 0.473 None gnomAD-4.0.0 6.57186E-06 None None None None I None 2.41289E-05 0 None 0 0 None 0 0 0 0 0
I/V 31740 Fn3-119 33 None 0.1003 None None N 0.128 0.121 0.415055319159 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/S 31941 Fn3-121 33 rs779376834 0.7413 -2.402 0.966 N 0.753 0.518 0.846433868311 gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
I/S 31941 Fn3-121 33 rs779376834 0.7413 -2.402 0.966 N 0.753 0.518 0.846433868311 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/S 31941 Fn3-121 33 rs779376834 0.7413 -2.402 0.966 N 0.753 0.518 0.846433868311 gnomAD-4.0.0 9.2961E-06 None None None None I None 0 0 None 0 0 None 0 0 1.27152E-05 0 0
I/T 31941 Fn3-121 33 rs779376834 0.3595 -2.144 0.801 N 0.693 0.484 0.777538414374 gnomAD-2.1.1 3.18E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
I/T 31941 Fn3-121 33 rs779376834 0.3595 -2.144 0.801 N 0.693 0.484 0.777538414374 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
I/T 31941 Fn3-121 33 rs779376834 0.3595 -2.144 0.801 N 0.693 0.484 0.777538414374 gnomAD-4.0.0 2.47896E-06 None None None None I None 0 0 None 0 0 None 0 0 3.39072E-06 0 0
I/V 31941 Fn3-121 33 rs750955565 0.0755 -1.409 0.007 N 0.153 0.097 0.457286136841 gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
I/V 31941 Fn3-121 33 rs750955565 0.0755 -1.409 0.007 N 0.153 0.097 0.457286136841 gnomAD-4.0.0 3.18281E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71772E-06 0 0
V/A 32137 Fn3-122 33 None 0.8681 None 0.992 N 0.662 0.421 0.54963036629 gnomAD-4.0.0 1.20033E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
V/I 32137 Fn3-122 33 rs2857279 0.0859 None 0.619 N 0.351 0.166 0.352476196916 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 32137 Fn3-122 33 rs2857279 0.0859 None 0.619 N 0.351 0.166 0.352476196916 gnomAD-4.0.0 6.57013E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46981E-05 0 0
L/H 32234 Fn3-123 33 None 0.9006 None 1.0 N 0.827 0.666 0.817826572935 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/P 32432 Fn3-124 34 rs1199606807 0.6024 -1.481 0.995 N 0.813 0.418 0.799146553086 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
V/A 32531 Fn3-125 33 rs1060500477 0.8216 None 0.517 N 0.639 0.379 0.529060795929 gnomAD-4.0.0 1.59214E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85979E-06 0 0
V/E 32531 Fn3-125 33 rs1060500477 0.9454 -1.463 0.983 N 0.817 0.53 0.827132642323 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
V/E 32531 Fn3-125 33 rs1060500477 0.9454 -1.463 0.983 N 0.817 0.53 0.827132642323 gnomAD-4.0.0 1.59214E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85979E-06 0 0
V/M 32531 Fn3-125 33 None 0.4931 None 0.901 N 0.652 0.383 0.414930877219 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
V/L 32632 Fn3-126 33 None 0.5112 None 0.948 N 0.489 0.263 0.468420198123 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
I/V 32828 Fn3-127 34 rs199689554 0.1529 -1.349 0.003 N 0.229 0.139 0.471778926243 gnomAD-2.1.1 4.28E-05 None None None None N None 0 0 None 0 6.14502E-04 None 0 None 0 0 0
I/V 32828 Fn3-127 34 rs199689554 0.1529 -1.349 0.003 N 0.229 0.139 0.471778926243 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 3.86698E-04 None 0 0 0 0 0
I/V 32828 Fn3-127 34 rs199689554 0.1529 -1.349 0.003 N 0.229 0.139 0.471778926243 gnomAD-4.0.0 1.67304E-05 None None None None N None 0 0 None 0 5.12706E-04 None 0 0 0 2.19582E-05 3.20102E-05
V/A 32929 Fn3-128 34 None 0.9457 None 0.998 N 0.63 0.408 0.62434799699 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 32929 Fn3-128 34 rs2154139645 0.0818 None 0.767 N 0.363 0.237 0.411133732114 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/F 33323 Fn3-130 34 rs1453366713 0.9712 -1.747 0.991 D 0.75 0.476 0.78845046722 gnomAD-2.1.1 8.06E-06 None None None None I None 0 5.81E-05 None 0 0 None 0 None 0 0 0
I/F 33323 Fn3-130 34 rs1453366713 0.9712 -1.747 0.991 D 0.75 0.476 0.78845046722 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
I/F 33323 Fn3-130 34 rs1453366713 0.9712 -1.747 0.991 D 0.75 0.476 0.78845046722 gnomAD-4.0.0 3.84423E-06 None None None None I None 0 5.08699E-05 None 0 0 None 0 0 0 0 0
I/F 33424 Fn3-131 33 rs1264517895 0.8112 -1.746 1.0 D 0.835 0.543 0.564835144235 gnomAD-2.1.1 4.41E-06 None None None None I None 0 0 None 0 0 None 4.07E-05 None 0 0 0
I/F 33424 Fn3-131 33 rs1264517895 0.8112 -1.746 1.0 D 0.835 0.543 0.564835144235 gnomAD-4.0.0 5.58079E-06 None None None None I None 0 0 None 0 0 None 0 0 0 9.914E-05 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.