Structural position:

  • Domain Type: Fn3
  • Aligned Position: 39
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand C

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
V/F 15693 Fn3-1 37 None 0.4974 None 0.993 N 0.758 0.288 0.729033515045 gnomAD-4.0.0 6.84719E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99931E-07 0 0
V/I 15693 Fn3-1 37 rs201717871 0.0793 -0.765 0.213 N 0.268 0.093 None gnomAD-2.1.1 7.49093E-04 None None None None N None 3.72424E-04 1.13585E-04 None 0 4.15498E-04 None 7.5188E-04 None 0 1.26401E-03 5.63222E-04
V/I 15693 Fn3-1 37 rs201717871 0.0793 -0.765 0.213 N 0.268 0.093 None gnomAD-3.1.2 7.04448E-04 None None None None N None 4.34678E-04 1.96954E-04 0 0 1.95084E-04 None 0 0 1.22264E-03 4.1425E-04 0
V/I 15693 Fn3-1 37 rs201717871 0.0793 -0.765 0.213 N 0.268 0.093 None 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 0 1E-03 None None None 1E-03 None
V/I 15693 Fn3-1 37 rs201717871 0.0793 -0.765 0.213 N 0.268 0.093 None gnomAD-4.0.0 1.67012E-03 None None None None N None 3.60279E-04 1.00224E-04 None 3.38341E-05 1.34487E-04 None 4.68765E-05 0 2.15932E-03 3.95378E-04 1.08974E-03
V/I 15794 Fn3-2 37 rs727504878 0.0627 -0.73 0.002 N 0.275 0.033 0.178374595973 gnomAD-2.1.1 1.08791E-04 None None None None N None 0 0 None 0 0 None 8.82468E-04 None 0 0 0
V/I 15794 Fn3-2 37 rs727504878 0.0627 -0.73 0.002 N 0.275 0.033 0.178374595973 gnomAD-3.1.2 3.95E-05 None None None None N None 2.42E-05 0 0 0 1.95313E-04 None 0 0 0 8.29531E-04 0
V/I 15794 Fn3-2 37 rs727504878 0.0627 -0.73 0.002 N 0.275 0.033 0.178374595973 gnomAD-4.0.0 6.4498E-05 None None None None N None 1.33733E-05 0 None 0 1.11837E-04 None 0 0 5.93671E-06 9.88424E-04 1.60287E-05
I/T 15895 Fn3-3 37 rs768530598 0.3632 -2.675 1.0 N 0.721 0.445 0.749324134746 gnomAD-2.1.1 1.38E-05 None None None None N None 0 7.03E-05 None 0 0 None 0 None 0 1E-05 0
I/T 15895 Fn3-3 37 rs768530598 0.3632 -2.675 1.0 N 0.721 0.445 0.749324134746 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 4.78011E-04
I/T 15895 Fn3-3 37 rs768530598 0.3632 -2.675 1.0 N 0.721 0.445 0.749324134746 gnomAD-4.0.0 8.81579E-06 None None None None N None 0 1.85977E-05 None 0 0 None 0 0 1.02487E-05 0 1.62623E-05
V/I 16091 Fn3-4 37 rs369143612 0.0726 -0.712 0.064 N 0.382 0.097 None gnomAD-2.1.1 3.94E-05 None None None None N None 2.48488E-04 2.83E-05 None 0 0 None 9.81E-05 None 0 0 1.40805E-04
V/I 16091 Fn3-4 37 rs369143612 0.0726 -0.712 0.064 N 0.382 0.097 None gnomAD-3.1.2 5.93E-05 None None None None N None 1.69115E-04 6.57E-05 0 0 0 None 0 0 0 2.07469E-04 0
V/I 16091 Fn3-4 37 rs369143612 0.0726 -0.712 0.064 N 0.382 0.097 None gnomAD-4.0.0 1.05436E-05 None None None None N None 1.06826E-04 5.00701E-05 None 0 0 None 0 0 1.6965E-06 4.39464E-05 0
V/L 16091 Fn3-4 37 rs369143612 0.1414 None None N 0.157 0.126 0.0806252709748 gnomAD-3.1.2 6.59E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
V/L 16091 Fn3-4 37 rs369143612 0.1414 None None N 0.157 0.126 0.0806252709748 gnomAD-4.0.0 6.58692E-06 None None None None N None 2.41593E-05 0 None 0 0 None 0 0 0 0 0
I/M 16191 Fn3-5 37 None 0.1031 None 0.002 D 0.403 0.11 0.364141725642 gnomAD-4.0.0 4.78124E-06 None None None None N None 0 0 None 0 0 None 0 0 8.59013E-06 0 0
I/T 16191 Fn3-5 37 rs372753303 0.1878 -2.447 0.055 N 0.581 0.114 None gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
I/T 16191 Fn3-5 37 rs372753303 0.1878 -2.447 0.055 N 0.581 0.114 None gnomAD-4.0.0 4.79266E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39984E-06 0 1.65821E-05
I/V 16191 Fn3-5 37 rs747433688 0.083 -1.36 0.005 N 0.385 0.051 0.281780670237 gnomAD-2.1.1 3.93E-05 None None None None N None 0 0 None 0 0 None 0 None 0 7.83E-05 1.40687E-04
I/V 16191 Fn3-5 37 rs747433688 0.083 -1.36 0.005 N 0.385 0.051 0.281780670237 gnomAD-3.1.2 3.95E-05 None None None None N None 0 0 0 0 0 None 0 0 7.36E-05 0 4.77555E-04
I/V 16191 Fn3-5 37 rs747433688 0.083 -1.36 0.005 N 0.385 0.051 0.281780670237 gnomAD-4.0.0 6.63561E-05 None None None None N None 0 0 None 0 0 None 1.56187E-05 0 8.73571E-05 0 4.80769E-05
V/A 16387 Fn3-6 37 rs765925142 0.6353 -2.437 0.104 N 0.634 0.262 0.537262924806 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.65E-05 None 0 None 0 0 0
V/A 16387 Fn3-6 37 rs765925142 0.6353 -2.437 0.104 N 0.634 0.262 0.537262924806 gnomAD-4.0.0 1.59357E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86144E-06 0 0
W/R 16486 Fn3-7 37 None 0.9714 None 1.0 N 0.802 0.522 0.586174608782 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.95465E-04 None 0 0 0 0 0
W/R 16486 Fn3-7 37 None 0.9714 None 1.0 N 0.802 0.522 0.586174608782 gnomAD-4.0.0 6.58371E-06 None None None None I None 0 0 None 0 1.95465E-04 None 0 0 0 0 0
W/S 16486 Fn3-7 37 rs774023517 0.8985 -2.319 1.0 N 0.791 0.397 0.783064499603 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
W/S 16486 Fn3-7 37 rs774023517 0.8985 -2.319 1.0 N 0.791 0.397 0.783064499603 gnomAD-4.0.0 3.18725E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.86862E-05 0
V/A 16587 Fn3-8 37 None 0.4506 None 0.334 N 0.616 0.233 0.531581166724 gnomAD-4.0.0 1.59351E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86172E-06 0 0
V/G 16587 Fn3-8 37 None 0.6085 None 0.781 N 0.759 0.338 0.626364337782 gnomAD-4.0.0 1.59351E-06 None None None None N None 0 0 None 0 2.78909E-05 None 0 0 0 0 0
I/M 16687 Fn3-9 37 rs1559789920 0.3203 None 0.97 D 0.679 0.42 0.163833314356 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 5.67E-05 None 0 None 0 0 0
I/M 16687 Fn3-9 37 rs1559789920 0.3203 None 0.97 D 0.679 0.42 0.163833314356 gnomAD-4.0.0 1.59425E-06 None None None None N None 0 0 None 0 2.79298E-05 None 0 0 0 0 0
I/V 16687 Fn3-9 37 rs727504194 0.0956 -1.662 0.025 N 0.299 0.058 0.447311733946 gnomAD-2.1.1 7.33E-05 None None None None N None 0 4.95165E-04 None 0 0 None 0 None 0 0 1.67898E-04
I/V 16687 Fn3-9 37 rs727504194 0.0956 -1.662 0.025 N 0.299 0.058 0.447311733946 gnomAD-3.1.2 1.31636E-04 None None None None N None 0 1.31113E-03 0 0 0 None 0 0 0 0 0
I/V 16687 Fn3-9 37 rs727504194 0.0956 -1.662 0.025 N 0.299 0.058 0.447311733946 gnomAD-4.0.0 2.72912E-05 None None None None N None 0 7.18007E-04 None 0 0 None 0 0 0 0 1.60344E-05
V/L 16787 Fn3-10 37 rs1419766789 0.187 -0.611 0.009 N 0.551 0.095 0.130388298395 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/L 16787 Fn3-10 37 rs1419766789 0.187 -0.611 0.009 N 0.551 0.095 0.130388298395 gnomAD-4.0.0 6.58033E-06 None None None None N None 2.41429E-05 0 None 0 0 None 0 0 0 0 0
H/R 16888 Fn3-11 37 None 0.7628 None 0.896 N 0.654 0.409 0.289098819767 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/Y 16888 Fn3-11 37 None 0.2057 None 0.995 N 0.653 0.312 0.342865806769 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/F 17083 Fn3-12 37 rs746817480 0.4542 -1.433 0.999 N 0.759 0.362 None gnomAD-2.1.1 2.5E-05 None None None None N None 0 0 None 0 0 None 0 None 0 5.48E-05 0
V/F 17083 Fn3-12 37 rs746817480 0.4542 -1.433 0.999 N 0.759 0.362 None gnomAD-3.1.2 7.24E-05 None None None None N None 0 0 0 0 0 None 0 0 1.61908E-04 0 0
V/F 17083 Fn3-12 37 rs746817480 0.4542 -1.433 0.999 N 0.759 0.362 None gnomAD-4.0.0 1.28966E-04 None None None None N None 0 0 None 0 0 None 0 0 1.67902E-04 1.09825E-05 1.44231E-04
V/I 17083 Fn3-12 37 None 0.0853 None 0.973 N 0.601 0.223 0.562617508568 gnomAD-4.0.0 6.84535E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99834E-07 0 0
I/T 17183 Fn3-13 37 rs757000767 0.7463 -3.228 0.939 N 0.678 0.336 0.615520507219 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
I/T 17183 Fn3-13 37 rs757000767 0.7463 -3.228 0.939 N 0.678 0.336 0.615520507219 gnomAD-3.1.2 1.32E-05 None None None None N None 2.42E-05 6.57E-05 0 0 0 None 0 0 0 0 0
I/T 17183 Fn3-13 37 rs757000767 0.7463 -3.228 0.939 N 0.678 0.336 0.615520507219 gnomAD-4.0.0 3.8477E-06 None None None None N None 3.38914E-05 1.69624E-05 None 0 0 None 0 0 0 0 0
W/C 17505 Fn3-15 36 rs1160660090 0.8783 -1.351 0.999 N 0.707 0.383 0.298403945805 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 5.69E-05 None 0 None 0 0 0
W/C 17505 Fn3-15 36 rs1160660090 0.8783 -1.351 0.999 N 0.707 0.383 0.298403945805 gnomAD-4.0.0 1.59558E-06 None None None None N None 0 0 None 0 2.79595E-05 None 0 0 0 0 0
W/C 18202 Fn3-20 37 rs1476258275 0.896 -1.636 1.0 N 0.787 0.409 0.333154297509 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
W/C 18202 Fn3-20 37 rs1476258275 0.896 -1.636 1.0 N 0.787 0.409 0.333154297509 gnomAD-4.0.0 1.59335E-06 None None None None N None 0 2.28739E-05 None 0 0 None 0 0 0 0 0
W/R 18202 Fn3-20 37 None 0.9678 None 1.0 N 0.829 0.489 0.606415853132 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
I/N 18308 Fn3-21 37 rs369024446 0.5369 -2.93 0.999 N 0.831 0.464 0.758643912819 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
I/N 18308 Fn3-21 37 rs369024446 0.5369 -2.93 0.999 N 0.831 0.464 0.758643912819 gnomAD-4.0.0 6.84942E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00075E-07 0 0
I/S 18308 Fn3-21 37 rs369024446 0.416 -3.493 0.998 N 0.752 0.455 None gnomAD-2.1.1 8.09E-06 None None None None N None 0 2.92E-05 None 0 0 None 0 None 0 8.95E-06 0
I/S 18308 Fn3-21 37 rs369024446 0.416 -3.493 0.998 N 0.752 0.455 None gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/S 18308 Fn3-21 37 rs369024446 0.416 -3.493 0.998 N 0.752 0.455 None gnomAD-4.0.0 1.17879E-05 None None None None N None 0 1.67224E-05 None 0 0 None 0 0 1.5268E-05 0 0
I/T 18308 Fn3-21 37 None 0.1931 None 0.994 N 0.746 0.437 0.709987916888 gnomAD-4.0.0 6.84942E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00075E-07 0 0
I/V 18308 Fn3-21 37 None 0.0798 None 0.889 N 0.453 0.156 0.47409059586 gnomAD-4.0.0 4.8013E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25002E-06 0 0
I/S 18615 Fn3-23 37 rs1474944420 0.3094 -3.104 0.018 N 0.598 0.197 0.642681104822 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
I/S 18615 Fn3-23 37 rs1474944420 0.3094 -3.104 0.018 N 0.598 0.197 0.642681104822 gnomAD-4.0.0 3.42349E-06 None None None None N None 0 8.95857E-05 None 0 0 None 0 0 0 0 1.65761E-05
V/I 18821 Fn3-24 38 rs1576247575 0.0721 None 0.997 N 0.655 0.263 0.529260826313 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 18821 Fn3-24 38 rs1576247575 0.0721 None 0.997 N 0.655 0.263 0.529260826313 gnomAD-4.0.0 1.17994E-05 None None None None N None 0 0 None 0 0 None 0 0 1.52738E-05 1.10676E-05 0
W/R 18920 Fn3-25 37 rs1425662810 0.9836 -1.767 0.999 N 0.801 0.427 0.60221348894 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.01E-06 0
W/R 18920 Fn3-25 37 rs1425662810 0.9836 -1.767 0.999 N 0.801 0.427 0.60221348894 gnomAD-4.0.0 1.59347E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86043E-06 0 0
I/V 19024 Fn3-26 37 rs876658068 0.0699 None 0.022 N 0.324 0.087 0.430126000877 gnomAD-3.1.2 2.63E-05 None None None None N None 2.41E-05 1.31062E-04 0 0 0 None 0 0 1.47E-05 0 0
I/V 19024 Fn3-26 37 rs876658068 0.0699 None 0.022 N 0.324 0.087 0.430126000877 gnomAD-4.0.0 6.09015E-06 None None None None N None 1.74758E-05 1.23122E-04 None 0 0 None 0 0 1.20497E-06 9.39496E-05 0
I/V 19516 Fn3-29 38 rs776824040 0.114 -1.754 0.333 N 0.267 0.105 0.426084969639 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
I/V 19516 Fn3-29 38 rs776824040 0.114 -1.754 0.333 N 0.267 0.105 0.426084969639 gnomAD-4.0.0 1.59231E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85932E-06 0 0
I/T 19614 Fn3-30 36 rs199933004 0.4624 -2.901 0.822 N 0.684 0.345 None gnomAD-2.1.1 8.04E-05 None None None None N None 0 2.9E-05 None 1.59046E-03 0 None 0 None 0 2.66E-05 0
I/T 19614 Fn3-30 36 rs199933004 0.4624 -2.901 0.822 N 0.684 0.345 None gnomAD-3.1.2 4.61E-05 None None None None N None 0 0 0 1.7301E-03 0 None 0 0 1.47E-05 0 0
I/T 19614 Fn3-30 36 rs199933004 0.4624 -2.901 0.822 N 0.684 0.345 None gnomAD-4.0.0 4.52525E-05 None None None None N None 0 1.66834E-05 None 1.5887E-03 0 None 0 0 1.52599E-05 0 1.12108E-04
I/T 19716 Fn3-31 37 rs763636451 0.2052 -2.685 0.891 N 0.727 0.285 0.744399525587 gnomAD-4.0.0 2.05289E-06 None None None None N None 0 2.23684E-05 None 0 0 None 0 0 1.79914E-06 0 0
L/S 20013 Fn3-33 37 rs2050262481 0.3481 None 0.997 N 0.696 0.444 0.789519865058 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
L/S 20013 Fn3-33 37 rs2050262481 0.3481 None 0.997 N 0.696 0.444 0.789519865058 gnomAD-4.0.0 6.57903E-06 None None None None N None 2.41441E-05 0 None 0 0 None 0 0 0 0 0
I/T 20208 Fn3-34 38 rs752768925 0.2119 -2.747 1.0 N 0.707 0.414 0.731997862569 gnomAD-2.1.1 2.15E-05 None None None None N None 4.14E-05 0 None 0 0 None 0 None 0 3.92E-05 0
I/T 20208 Fn3-34 38 rs752768925 0.2119 -2.747 1.0 N 0.707 0.414 0.731997862569 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
I/T 20208 Fn3-34 38 rs752768925 0.2119 -2.747 1.0 N 0.707 0.414 0.731997862569 gnomAD-4.0.0 3.90537E-05 None None None None N None 1.33572E-05 0 None 0 0 None 0 0 5.17151E-05 0 1.60138E-05
Y/C 20307 Fn3-35 37 None 0.0932 None 0.975 N 0.553 0.369 0.615085622779 gnomAD-4.0.0 6.87165E-07 None None None None N None 0 0 None 0 0 None 0 0 9.03551E-07 0 0
Y/F 20307 Fn3-35 37 rs1553643111 0.0698 None 0.425 N 0.445 0.171 0.351180957027 gnomAD-4.0.0 1.37433E-06 None None None None N None 0 0 None 0 0 None 0 0 1.8071E-06 0 0
V/A 20407 Fn3-36 37 rs761797946 0.4777 -2.587 0.027 D 0.605 0.128 0.430923071578 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
V/A 20407 Fn3-36 37 rs761797946 0.4777 -2.587 0.027 D 0.605 0.128 0.430923071578 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
V/A 20407 Fn3-36 37 rs761797946 0.4777 -2.587 0.027 D 0.605 0.128 0.430923071578 gnomAD-4.0.0 3.09988E-06 None None None None N None 0 1.66834E-05 None 0 4.46508E-05 None 0 0 1.69579E-06 0 0
I/M 20605 Fn3-37 37 rs761374262 0.3031 -1.546 1.0 N 0.75 0.314 0.613267566169 gnomAD-2.1.1 1.79E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.9E-05 0
I/M 20605 Fn3-37 37 rs761374262 0.3031 -1.546 1.0 N 0.75 0.314 0.613267566169 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
I/M 20605 Fn3-37 37 rs761374262 0.3031 -1.546 1.0 N 0.75 0.314 0.613267566169 gnomAD-4.0.0 2.6654E-05 None None None None N None 0 0 None 0 0 None 0 0 3.64535E-05 0 0
I/T 20605 Fn3-37 37 rs140252432 0.445 -2.889 1.0 N 0.683 0.395 None gnomAD-2.1.1 2.41E-05 None None None None N None 1.29216E-04 0 None 0 1.68672E-04 None 0 None 0 0 1.65782E-04
I/T 20605 Fn3-37 37 rs140252432 0.445 -2.889 1.0 N 0.683 0.395 None gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 6.55E-05 0 0 1.93874E-04 None 0 0 0 0 0
I/T 20605 Fn3-37 37 rs140252432 0.445 -2.889 1.0 N 0.683 0.395 None 1000 genomes 3.99361E-04 None None None None N None 0 1.4E-03 None None 1E-03 0 None None None 0 None
I/T 20605 Fn3-37 37 rs140252432 0.445 -2.889 1.0 N 0.683 0.395 None gnomAD-4.0.0 7.69038E-06 None None None None N None 6.75379E-05 1.6956E-05 None 0 2.43499E-05 None 0 0 0 0 0
I/V 20605 Fn3-37 37 rs759096564 0.1415 -1.864 0.993 N 0.389 0.229 0.621134785655 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 8.87E-06 0
I/V 20605 Fn3-37 37 rs759096564 0.1415 -1.864 0.993 N 0.389 0.229 0.621134785655 gnomAD-4.0.0 8.21292E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19692E-06 4.63843E-05 0
H/D 20704 Fn3-38 37 rs1553641034 0.7617 None 0.852 N 0.703 0.314 0.36256342048 gnomAD-4.0.0 4.79085E-06 None None None None N None 0 0 None 0 0 None 0 3.47464E-04 2.69898E-06 0 3.31378E-05
H/R 20704 Fn3-38 37 rs770845631 0.4842 -2.203 0.959 N 0.689 0.264 0.305086939656 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
H/R 20704 Fn3-38 37 rs770845631 0.4842 -2.203 0.959 N 0.689 0.264 0.305086939656 gnomAD-4.0.0 1.59231E-06 None None None None N None 0 2.2877E-05 None 0 0 None 0 0 0 0 0
I/F 20900 Fn3-39 37 rs1320866364 0.4479 -1.652 1.0 N 0.765 0.395 0.450928719235 gnomAD-2.1.1 8.16E-06 None None None None N None 0 0 None 0 0 None 6.55E-05 None 0 0 0
I/F 20900 Fn3-39 37 rs1320866364 0.4479 -1.652 1.0 N 0.765 0.395 0.450928719235 gnomAD-4.0.0 3.19957E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86656E-05 0
I/T 20900 Fn3-39 37 rs770522021 0.6769 -2.782 1.0 N 0.711 0.425 0.652629836549 gnomAD-2.1.1 1.22E-05 None None None None N None 0 0 None 0 1.70203E-04 None 0 None 0 0 0
I/T 20900 Fn3-39 37 rs770522021 0.6769 -2.782 1.0 N 0.711 0.425 0.652629836549 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94401E-04 None 0 0 0 0 0
I/T 20900 Fn3-39 37 rs770522021 0.6769 -2.782 1.0 N 0.711 0.425 0.652629836549 gnomAD-4.0.0 6.57756E-06 None None None None N None 0 0 None 0 1.94401E-04 None 0 0 0 0 0
F/L 20999 Fn3-40 37 rs568886353 0.6107 None None N 0.19 0.098 0.112648838833 gnomAD-4.0.0 1.36885E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79932E-06 0 0
F/S 20999 Fn3-40 37 None 0.4855 None 0.014 N 0.466 0.2 0.226586394389 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
F/V 20999 Fn3-40 37 rs568886353 0.1434 -2.107 None N 0.253 0.121 None gnomAD-2.1.1 2.5E-05 None None None None N None 0 0 None 0 3.61309E-04 None 0 None 0 0 0
F/V 20999 Fn3-40 37 rs568886353 0.1434 -2.107 None N 0.253 0.121 None gnomAD-3.1.2 3.29E-05 None None None None N None 0 6.56E-05 0 0 7.76398E-04 None 0 0 0 0 0
F/V 20999 Fn3-40 37 rs568886353 0.1434 -2.107 None N 0.253 0.121 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
F/V 20999 Fn3-40 37 rs568886353 0.1434 -2.107 None N 0.253 0.121 None gnomAD-4.0.0 1.48771E-05 None None None None N None 0 1.66778E-05 None 0 3.12961E-04 None 0 0 0 0 1.44083E-04
V/A 21100 Fn3-41 37 None 0.4094 None 0.027 N 0.585 0.126 0.580120749226 gnomAD-4.0.0 6.84561E-07 None None None None N None 0 0 None 0 0 None 0 0 8.998E-07 0 0
V/I 21100 Fn3-41 37 rs774240012 0.0746 -0.785 None N 0.279 0.045 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/I 21100 Fn3-41 37 rs774240012 0.0746 -0.785 None N 0.279 0.045 None gnomAD-4.0.0 1.36912E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.32002E-05 0
I/N 21302 Fn3-42 37 rs1228375240 0.5168 None 0.999 N 0.759 0.412 0.788716532118 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/N 21302 Fn3-42 37 rs1228375240 0.5168 None 0.999 N 0.759 0.412 0.788716532118 gnomAD-4.0.0 6.57912E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47145E-05 0 0
I/V 21302 Fn3-42 37 None 0.0757 None 0.333 N 0.242 0.062 0.424670345773 gnomAD-4.0.0 6.84514E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99698E-07 0 0
I/V 21402 Fn3-43 37 rs1157697777 0.0986 -1.231 0.002 N 0.248 0.086 0.42264334713 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/V 21402 Fn3-43 37 rs1157697777 0.0986 -1.231 0.002 N 0.248 0.086 0.42264334713 gnomAD-4.0.0 4.77809E-06 None None None None I None 0 4.5754E-05 None 0 0 None 1.88253E-05 0 0 0 0
I/R 21596 Fn3-44 38 None 0.6668 None 0.667 N 0.703 0.465 0.779246962076 gnomAD-4.0.0 6.84363E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99635E-07 0 0
I/T 21596 Fn3-44 38 rs779333272 0.2401 -2.826 0.124 N 0.57 0.267 0.646260075106 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
I/T 21596 Fn3-44 38 rs779333272 0.2401 -2.826 0.124 N 0.57 0.267 0.646260075106 gnomAD-4.0.0 6.84363E-07 None None None None I None 0 0 None 0 2.52181E-05 None 0 0 0 0 0
L/R 21695 Fn3-45 37 rs1174402887 0.187 -1.559 0.989 N 0.632 0.3 0.729612430995 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
L/R 21695 Fn3-45 37 rs1174402887 0.187 -1.559 0.989 N 0.632 0.3 0.729612430995 gnomAD-4.0.0 1.59233E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43299E-05 0
I/V 21992 Fn3-47 37 None 0.0696 None 0.02 N 0.249 0.077 0.371157983038 gnomAD-4.0.0 1.59321E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86151E-06 0 0
L/S 22091 Fn3-48 37 None 0.4563 None 0.939 N 0.622 0.382 0.488055169367 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/F 22192 Fn3-49 37 None 0.3584 None 0.988 N 0.763 0.286 0.581410409299 gnomAD-4.0.0 1.59535E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86425E-06 0 0
L/P 22192 Fn3-49 37 None 0.9933 None 0.998 N 0.816 0.572 0.838659699283 gnomAD-4.0.0 2.40066E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 1.31251E-06 0 0
V/L 22390 Fn3-50 37 None 0.4096 None 0.247 N 0.493 0.187 0.495506531988 gnomAD-4.0.0 6.84382E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99672E-07 0 0
V/M 22390 Fn3-50 37 rs778578056 0.3389 -1.226 0.942 N 0.759 0.256 0.596538173739 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
V/M 22390 Fn3-50 37 rs778578056 0.3389 -1.226 0.942 N 0.759 0.256 0.596538173739 gnomAD-4.0.0 6.84382E-07 None None None None N None 2.99097E-05 0 None 0 0 None 0 0 0 0 0
V/A 22487 Fn3-51 37 rs879097484 0.1984 None None N 0.221 0.113 None gnomAD-4.0.0 2.05323E-06 None None None None N None 0 0 None 0 0 None 1.87329E-05 0 8.99672E-07 0 1.65744E-05
I/V 22680 Fn3-52 38 rs2047081952 0.0873 None None N 0.281 0.087 0.393006254552 gnomAD-4.0.0 1.59238E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
H/N 22779 Fn3-53 37 rs727504702 0.2929 -2.1 0.931 N 0.598 0.326 0.284539287134 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 4.95E-05 0 0
H/N 22779 Fn3-53 37 rs727504702 0.2929 -2.1 0.931 N 0.598 0.326 0.284539287134 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
H/N 22779 Fn3-53 37 rs727504702 0.2929 -2.1 0.931 N 0.598 0.326 0.284539287134 gnomAD-4.0.0 3.85763E-06 None None None None N None 1.69411E-05 0 None 0 0 None 1.60948E-05 0 2.3964E-06 0 0
H/R 22779 Fn3-53 37 rs2046870032 0.531 None 0.939 N 0.591 0.398 0.290222751274 gnomAD-4.0.0 1.20036E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31255E-06 0 0
I/M 22877 Fn3-54 37 rs776873491 0.0894 -1.553 0.078 N 0.307 0.167 0.46512379133 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
I/M 22877 Fn3-54 37 rs776873491 0.0894 -1.553 0.078 N 0.307 0.167 0.46512379133 gnomAD-4.0.0 1.59314E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86077E-06 0 0
I/V 22877 Fn3-54 37 rs879104670 0.0779 -1.875 0.012 N 0.213 0.046 None gnomAD-3.1.2 1.99E-05 None None None None N None 2.44E-05 6.58E-05 0 0 0 None 0 0 1.48E-05 0 0
I/V 22877 Fn3-54 37 rs879104670 0.0779 -1.875 0.012 N 0.213 0.046 None gnomAD-4.0.0 6.20401E-06 None None None None N None 1.34445E-05 1.67056E-05 None 0 0 None 0 0 6.78443E-06 0 0
I/M 23076 Fn3-55 37 None 0.1144 None 0.317 N 0.595 0.151 0.315609569513 gnomAD-4.0.0 1.36875E-06 None None None None I None 0 0 None 0 2.52525E-05 None 0 0 0 1.15955E-05 0
I/T 23076 Fn3-55 37 rs765930349 0.1428 -2.471 0.002 N 0.336 0.087 0.532168211543 gnomAD-2.1.1 2.42E-05 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 4.45E-05 0
I/T 23076 Fn3-55 37 rs765930349 0.1428 -2.471 0.002 N 0.336 0.087 0.532168211543 gnomAD-3.1.2 1.97E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
I/T 23076 Fn3-55 37 rs765930349 0.1428 -2.471 0.002 N 0.336 0.087 0.532168211543 gnomAD-4.0.0 1.30178E-05 None None None None I None 4.00759E-05 0 None 0 0 None 3.12568E-05 0 1.35644E-05 0 0
I/V 23076 Fn3-55 37 rs1203126727 0.0606 -1.594 None N 0.172 0.044 0.233150807113 gnomAD-2.1.1 8.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
I/V 23076 Fn3-55 37 rs1203126727 0.0606 -1.594 None N 0.172 0.044 0.233150807113 gnomAD-4.0.0 8.21248E-06 None None None None I None 0 0 None 0 0 None 0 0 1.07955E-05 0 0
H/N 23175 Fn3-56 37 None 0.2113 None 0.491 N 0.562 0.061 0.219573609325 gnomAD-4.0.0 1.59167E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85922E-06 0 0
H/P 23175 Fn3-56 37 None 0.915 None 0.873 N 0.689 0.294 0.343101102393 gnomAD-4.0.0 1.36878E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79946E-06 0 0
H/R 23175 Fn3-56 37 rs1186507360 0.2243 -1.87 0.662 N 0.599 0.174 0.234412748748 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
H/R 23175 Fn3-56 37 rs1186507360 0.2243 -1.87 0.662 N 0.599 0.174 0.234412748748 gnomAD-4.0.0 1.36873E-06 None None None None N None 2.99025E-05 0 None 0 0 None 0 0 0 0 1.65706E-05
I/M 23471 Fn3-58 37 rs764793576 0.3167 -1.382 0.99 N 0.703 0.339 0.550334908387 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
I/T 23471 Fn3-58 37 rs1475765674 0.4548 None 0.972 N 0.663 0.414 0.70371367467 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 23471 Fn3-58 37 rs1475765674 0.4548 None 0.972 N 0.663 0.414 0.70371367467 gnomAD-4.0.0 4.33881E-06 None None None None N None 0 0 None 0 0 None 0 0 5.934E-06 0 0
I/V 23471 Fn3-58 37 None 0.0823 None 0.006 N 0.281 0.06 0.470890129789 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
V/M 23568 Fn3-59 37 rs748847402 0.3007 -0.901 0.967 N 0.661 0.19 0.582733548269 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/M 23568 Fn3-59 37 rs748847402 0.3007 -0.901 0.967 N 0.661 0.19 0.582733548269 gnomAD-4.0.0 3.18351E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85932E-06 1.43303E-05 0
V/I 23763 Fn3-60 38 None 0.0694 None None N 0.225 0.065 0.350524144436 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
H/D 23862 Fn3-61 37 rs774224899 0.6433 -1.326 1.0 N 0.751 0.492 0.417081434665 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
H/D 23862 Fn3-61 37 rs774224899 0.6433 -1.326 1.0 N 0.751 0.492 0.417081434665 gnomAD-4.0.0 2.05286E-06 None None None None N None 0 2.23614E-05 None 0 0 None 0 0 1.79914E-06 0 0
H/Q 23862 Fn3-61 37 None 0.3397 None 1.0 N 0.771 0.254 0.187945064343 gnomAD-4.0.0 1.23171E-05 None None None None N None 0 0 None 0 0 None 0 0 1.61922E-05 0 0
H/R 23862 Fn3-61 37 rs576552787 0.2098 -1.679 1.0 N 0.755 0.373 0.353125101423 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
H/R 23862 Fn3-61 37 rs576552787 0.2098 -1.679 1.0 N 0.755 0.373 0.353125101423 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
H/R 23862 Fn3-61 37 rs576552787 0.2098 -1.679 1.0 N 0.755 0.373 0.353125101423 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
H/R 23862 Fn3-61 37 rs576552787 0.2098 -1.679 1.0 N 0.755 0.373 0.353125101423 gnomAD-4.0.0 1.85918E-05 None None None None N None 1.33262E-05 0 None 0 0 None 0 0 2.28886E-05 0 3.20164E-05
I/M 23960 Fn3-62 37 rs1366447660 0.0725 -0.921 0.006 N 0.457 0.19 0.225902525712 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
I/M 23960 Fn3-62 37 rs1366447660 0.0725 -0.921 0.006 N 0.457 0.19 0.225902525712 gnomAD-3.1.2 1.32E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
I/M 23960 Fn3-62 37 rs1366447660 0.0725 -0.921 0.006 N 0.457 0.19 0.225902525712 gnomAD-4.0.0 3.10035E-06 None None None None N None 1.33554E-05 0 None 0 0 None 0 0 3.39227E-06 0 0
I/T 23960 Fn3-62 37 rs568223521 0.0895 -2.237 None N 0.369 0.119 0.612591404863 gnomAD-2.1.1 1.43E-05 None None None None N None 1.65426E-04 0 None 0 0 None 0 None 0 0 0
I/T 23960 Fn3-62 37 rs568223521 0.0895 -2.237 None N 0.369 0.119 0.612591404863 gnomAD-3.1.2 2.63E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
I/T 23960 Fn3-62 37 rs568223521 0.0895 -2.237 None N 0.369 0.119 0.612591404863 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
I/T 23960 Fn3-62 37 rs568223521 0.0895 -2.237 None N 0.369 0.119 0.612591404863 gnomAD-4.0.0 2.62771E-05 None None None None N None 9.62186E-05 0 None 0 0 None 0 0 0 0 0
I/V 23960 Fn3-62 37 rs1198927435 0.0658 None None N 0.231 0.052 0.27855597813 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 23960 Fn3-62 37 rs1198927435 0.0658 None None N 0.231 0.052 0.27855597813 gnomAD-4.0.0 2.02992E-06 None None None None N None 0 0 None 0 0 None 0 0 2.4099E-06 0 0
I/V 24159 Fn3-63 38 rs371764714 0.0574 -1.827 None N 0.246 0.057 None gnomAD-2.1.1 3.86E-05 None None None None N None 2.56981E-04 0 None 0 0 None 0 None 0 1.97E-05 0
I/V 24159 Fn3-63 38 rs371764714 0.0574 -1.827 None N 0.246 0.057 None gnomAD-3.1.2 5.92E-05 None None None None N None 1.68829E-04 0 0 0 0 None 0 0 2.94E-05 0 0
I/V 24159 Fn3-63 38 rs371764714 0.0574 -1.827 None N 0.246 0.057 None gnomAD-4.0.0 2.11103E-05 None None None None N None 1.67103E-04 0 None 0 0 None 0 0 1.58717E-05 0 3.43513E-05
I/F 24258 Fn3-64 37 None 0.1558 None 0.82 D 0.757 0.196 0.590550950836 gnomAD-4.0.0 7.26417E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.40738E-05 0
I/T 24258 Fn3-64 37 rs773657520 0.1447 -3.04 0.722 N 0.743 0.223 0.674618586957 gnomAD-2.1.1 5.45E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.13E-05 0
I/T 24258 Fn3-64 37 rs773657520 0.1447 -3.04 0.722 N 0.743 0.223 0.674618586957 gnomAD-4.0.0 3.67939E-06 None None None None N None 0 0 None 0 0 None 0 0 6.46793E-06 0 0
I/V 24258 Fn3-64 37 rs763561377 0.0677 -1.887 0.003 N 0.218 0.041 0.357724736475 gnomAD-2.1.1 9.31E-06 None None None None N None 4.27E-05 0 None 0 0 None 0 None 0 9.64E-06 0
I/V 24258 Fn3-64 37 rs763561377 0.0677 -1.887 0.003 N 0.218 0.041 0.357724736475 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/V 24258 Fn3-64 37 rs763561377 0.0677 -1.887 0.003 N 0.218 0.041 0.357724736475 gnomAD-4.0.0 6.54155E-06 None None None None N None 1.38677E-05 0 None 0 0 None 0 0 7.02346E-06 0 1.7012E-05
M/T 24359 Fn3-65 37 rs1368475411 0.1266 -1.784 0.024 N 0.58 0.363 0.602933245068 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/T 24359 Fn3-65 37 rs1368475411 0.1266 -1.784 0.024 N 0.58 0.363 0.602933245068 gnomAD-4.0.0 2.56396E-06 None None None None N None 1.69245E-05 0 None 0 0 None 0 0 2.39427E-06 0 0
M/V 24359 Fn3-65 37 rs1469212493 0.0609 -0.937 None N 0.223 0.317 0.456368778954 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 6.50195E-04 None 0 None 0 0 0
M/V 24359 Fn3-65 37 rs1469212493 0.0609 -0.937 None N 0.223 0.317 0.456368778954 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94024E-04 None 0 0 0 0 0
M/V 24359 Fn3-65 37 rs1469212493 0.0609 -0.937 None N 0.223 0.317 0.456368778954 gnomAD-4.0.0 6.5754E-06 None None None None N None 0 0 None 0 1.94024E-04 None 0 0 0 0 0
I/V 24555 Fn3-66 37 rs1708576305 0.0879 None 0.987 N 0.408 0.147 0.468003879618 gnomAD-4.0.0 1.59304E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86153E-06 0 0
I/F 24652 Fn3-67 37 rs760045336 0.1809 -1.563 0.988 N 0.548 0.332 0.622623412334 gnomAD-2.1.1 6.37E-05 None None None None N None 2.2941E-04 0 None 0 0 None 0 None 0 0 0
I/F 24652 Fn3-67 37 rs760045336 0.1809 -1.563 0.988 N 0.548 0.332 0.622623412334 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
I/F 24652 Fn3-67 37 rs760045336 0.1809 -1.563 0.988 N 0.548 0.332 0.622623412334 gnomAD-4.0.0 5.12675E-06 None None None None N None 3.38318E-05 0 None 0 0 None 0 0 4.7878E-06 0 0
I/L 24652 Fn3-67 37 None 0.1106 None 0.266 N 0.438 0.122 0.583365392187 gnomAD-4.0.0 1.5921E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85938E-06 0 0
I/N 24652 Fn3-67 37 None 0.2673 None 0.286 N 0.585 0.278 0.663445045466 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
I/N 24652 Fn3-67 37 None 0.2673 None 0.286 N 0.585 0.278 0.663445045466 gnomAD-4.0.0 6.57454E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07039E-04 0
I/S 24652 Fn3-67 37 rs377752584 0.2592 -2.305 0.968 N 0.6 0.303 0.739879714019 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/S 24652 Fn3-67 37 rs377752584 0.2592 -2.305 0.968 N 0.6 0.303 0.739879714019 gnomAD-4.0.0 1.36872E-06 None None None None N None 0 2.23694E-05 None 0 0 None 0 0 8.99582E-07 0 0
I/T 24652 Fn3-67 37 rs377752584 0.1146 -2.036 0.9 N 0.544 0.333 None gnomAD-2.1.1 6.37E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.29634E-04 0
I/T 24652 Fn3-67 37 rs377752584 0.1146 -2.036 0.9 N 0.544 0.333 None gnomAD-3.1.2 2.63E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 4.41E-05 0 0
I/T 24652 Fn3-67 37 rs377752584 0.1146 -2.036 0.9 N 0.544 0.333 None gnomAD-4.0.0 4.95871E-06 None None None None N None 1.33511E-05 0 None 3.37883E-05 2.23494E-05 None 0 0 4.23865E-06 0 0
I/L 24845 Fn3-68 38 rs1214451388 0.3337 -1.452 0.889 N 0.412 0.133 0.542100083394 gnomAD-2.1.1 2.02E-05 None None None None N None 6.49E-05 0 None 0 0 None 0 None 0 3.59E-05 0
I/L 24845 Fn3-68 38 rs1214451388 0.3337 -1.452 0.889 N 0.412 0.133 0.542100083394 gnomAD-4.0.0 1.50576E-05 None None None None N None 2.98954E-05 0 None 0 0 None 0 0 1.6193E-05 0 4.97216E-05
H/N 24944 Fn3-69 37 rs779868325 0.4472 -1.881 0.904 N 0.614 0.37 0.33110744837 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
H/N 24944 Fn3-69 37 rs779868325 0.4472 -1.881 0.904 N 0.614 0.37 0.33110744837 gnomAD-4.0.0 3.60101E-06 None None None None N None 0 0 None 0 0 None 0 0 3.93753E-06 0 0
H/R 24944 Fn3-69 37 rs1380943129 0.5338 -1.693 0.97 N 0.625 0.488 0.359557344763 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
H/R 24944 Fn3-69 37 rs1380943129 0.5338 -1.693 0.97 N 0.625 0.488 0.359557344763 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
H/R 24944 Fn3-69 37 rs1380943129 0.5338 -1.693 0.97 N 0.625 0.488 0.359557344763 gnomAD-4.0.0 6.57696E-06 None None None None N None 2.41371E-05 0 None 0 0 None 0 0 0 0 0
I/T 25042 Fn3-70 37 rs775091036 0.1253 -2.622 None N 0.418 0.1 None gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
I/T 25042 Fn3-70 37 rs775091036 0.1253 -2.622 None N 0.418 0.1 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.89E-05 0 0
I/T 25042 Fn3-70 37 rs775091036 0.1253 -2.622 None N 0.418 0.1 None gnomAD-4.0.0 5.58005E-06 None None None None N None 0 0 None 0 0 None 0 1.64636E-04 6.78423E-06 0 0
I/V 25042 Fn3-70 37 None 0.0581 None None N 0.173 0.066 0.188950314367 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
I/T 25241 Fn3-71 38 rs752485989 0.1415 -2.755 0.379 N 0.568 0.144 0.610711448424 gnomAD-2.1.1 1.21E-05 None None None None N None 0 2.91E-05 None 9.99E-05 5.63E-05 None 0 None 0 0 0
I/T 25241 Fn3-71 38 rs752485989 0.1415 -2.755 0.379 N 0.568 0.144 0.610711448424 gnomAD-4.0.0 7.5292E-06 None None None None N None 0 2.23754E-05 None 3.82907E-05 5.05894E-05 None 0 0 5.39763E-06 0 1.65733E-05
V/D 25340 Fn3-72 37 rs200287703 0.7772 -3.521 0.979 N 0.758 0.46 None gnomAD-2.1.1 2.21682E-04 None None None None N None 2.06731E-03 3.11333E-04 None 0 0 None 0 None 0 0 1.40449E-04
V/D 25340 Fn3-72 37 rs200287703 0.7772 -3.521 0.979 N 0.758 0.46 None gnomAD-3.1.2 6.2491E-04 None None None None N None 2.10145E-03 4.58595E-04 0 0 0 None 0 0 0 0 4.78011E-04
V/D 25340 Fn3-72 37 rs200287703 0.7772 -3.521 0.979 N 0.758 0.46 None 1000 genomes 3.99361E-04 None None None None N None 1.5E-03 0 None None 0 0 None None None 0 None
V/D 25340 Fn3-72 37 rs200287703 0.7772 -3.521 0.979 N 0.758 0.46 None gnomAD-4.0.0 1.30157E-04 None None None None N None 2.46772E-03 3.0002E-04 None 0 0 None 0 0 0 0 1.12061E-04
V/I 25340 Fn3-72 37 rs1207970602 0.065 -0.821 0.003 N 0.263 0.073 0.268660756437 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
V/I 25340 Fn3-72 37 rs1207970602 0.065 -0.821 0.003 N 0.263 0.073 0.268660756437 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/I 25340 Fn3-72 37 rs1207970602 0.065 -0.821 0.003 N 0.263 0.073 0.268660756437 gnomAD-4.0.0 3.84504E-06 None None None None N None 3.38513E-05 0 None 0 0 None 0 0 0 0 2.84527E-05
V/L 25340 Fn3-72 37 None 0.1492 None 0.164 N 0.523 0.109 0.37550373646 gnomAD-4.0.0 1.59191E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43299E-05 0
I/V 25441 Fn3-73 37 rs759489696 0.0625 -1.487 0.333 N 0.255 0.044 0.416581338634 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
I/V 25441 Fn3-73 37 rs759489696 0.0625 -1.487 0.333 N 0.255 0.044 0.416581338634 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 25441 Fn3-73 37 rs759489696 0.0625 -1.487 0.333 N 0.255 0.044 0.416581338634 gnomAD-4.0.0 4.33889E-06 None None None None N None 1.33522E-05 0 None 0 0 None 0 0 2.54318E-06 2.19645E-05 1.60169E-05
I/V 25637 Fn3-74 37 rs1282968520 0.0739 -1.834 0.011 N 0.265 0.076 0.427713192076 gnomAD-2.1.1 8.26E-06 None None None None N None 0 0 None 0 5.61E-05 None 3.47E-05 None 0 0 0
I/V 25637 Fn3-74 37 rs1282968520 0.0739 -1.834 0.011 N 0.265 0.076 0.427713192076 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.93498E-04 None 0 0 0 0 0
I/V 25637 Fn3-74 37 rs1282968520 0.0739 -1.834 0.011 N 0.265 0.076 0.427713192076 gnomAD-4.0.0 3.73926E-06 None None None None N None 0 0 None 0 2.23424E-05 None 0 0 2.5535E-06 1.11527E-05 1.61337E-05
I/V 25734 Fn3-75 37 None 0.0735 None 0.002 N 0.192 0.052 0.408853032482 gnomAD-4.0.0 2.73739E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69874E-06 0 1.65689E-05
I/L 25927 Fn3-76 38 rs780196850 0.2304 -1.403 0.025 N 0.427 0.094 None gnomAD-2.1.1 1.79E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.91E-05 0
I/L 25927 Fn3-76 38 rs780196850 0.2304 -1.403 0.025 N 0.427 0.094 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/L 25927 Fn3-76 38 rs780196850 0.2304 -1.403 0.025 N 0.427 0.094 None gnomAD-4.0.0 4.52491E-05 None None None None N None 0 0 None 0 0 None 0 0 5.0864E-05 0 2.08247E-04
I/M 25927 Fn3-76 38 rs1226545466 0.1649 -1.713 0.497 N 0.647 0.203 0.423480098753 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
I/M 25927 Fn3-76 38 rs1226545466 0.1649 -1.713 0.497 N 0.647 0.203 0.423480098753 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/M 25927 Fn3-76 38 rs1226545466 0.1649 -1.713 0.497 N 0.647 0.203 0.423480098753 gnomAD-4.0.0 1.11574E-05 None None None None N None 0 0 None 0 0 None 0 0 1.52592E-05 0 0
I/T 25927 Fn3-76 38 rs905403082 0.2042 -2.947 0.124 N 0.595 0.269 0.549545986626 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
I/T 25927 Fn3-76 38 rs905403082 0.2042 -2.947 0.124 N 0.595 0.269 0.549545986626 gnomAD-4.0.0 2.05314E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79919E-06 0 1.65739E-05
I/V 25927 Fn3-76 38 rs780196850 0.07 -1.938 None N 0.241 0.064 0.467585353272 gnomAD-2.1.1 2.14E-05 None None None None N None 4.14E-05 0 None 0 0 None 0 None 0 3.91E-05 0
I/V 25927 Fn3-76 38 rs780196850 0.07 -1.938 None N 0.241 0.064 0.467585353272 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
I/V 25927 Fn3-76 38 rs780196850 0.07 -1.938 None N 0.241 0.064 0.467585353272 gnomAD-4.0.0 1.98352E-05 None None None None N None 1.33511E-05 0 None 0 0 None 0 0 2.62797E-05 0 0
H/N 26026 Fn3-77 37 None 0.5377 None 0.904 N 0.61 0.388 0.328222422547 gnomAD-4.0.0 1.59222E-06 None None None None N None 0 0 None 0 2.77963E-05 None 0 0 0 0 0
H/Q 26026 Fn3-77 37 rs1353297321 0.7396 None 0.97 N 0.635 0.314 0.369682402691 gnomAD-4.0.0 6.84382E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99603E-07 0 0
H/Y 26026 Fn3-77 37 rs1164632947 0.1818 0.378 0.014 N 0.479 0.343 0.229264304666 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
H/Y 26026 Fn3-77 37 rs1164632947 0.1818 0.378 0.014 N 0.479 0.343 0.229264304666 gnomAD-4.0.0 1.59222E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85959E-06 0 0
I/L 26124 Fn3-78 37 None 0.1385 None 0.437 D 0.461 0.174 0.474954162714 gnomAD-4.0.0 6.84357E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99611E-07 0 0
I/M 26124 Fn3-78 37 None 0.1088 None 0.984 N 0.769 0.33 0.532359089423 gnomAD-4.0.0 2.05312E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69891E-06 0 0
I/N 26124 Fn3-78 37 rs778290450 0.4197 -2.639 0.995 N 0.795 0.479 0.767080534469 gnomAD-2.1.1 7.51E-05 None None None None N None 0 1.69904E-04 None 5.81283E-04 0 None 0 None 0 5.48E-05 2.81452E-04
I/N 26124 Fn3-78 37 rs778290450 0.4197 -2.639 0.995 N 0.795 0.479 0.767080534469 gnomAD-3.1.2 3.94E-05 None None None None N None 2.41E-05 1.31148E-04 0 2.88018E-04 0 None 0 0 2.94E-05 0 0
I/N 26124 Fn3-78 37 rs778290450 0.4197 -2.639 0.995 N 0.795 0.479 0.767080534469 gnomAD-4.0.0 2.29342E-05 None None None None N None 1.33533E-05 1.5011E-04 None 3.04218E-04 0 None 0 0 1.18688E-05 0 6.40615E-05
I/T 26124 Fn3-78 37 rs778290450 0.1456 -2.803 0.896 N 0.768 0.212 0.610115391599 gnomAD-2.1.1 2.86E-05 None None None None N None 0 1.1327E-04 None 0 5.14E-05 None 0 None 0 2.35E-05 0
I/T 26124 Fn3-78 37 rs778290450 0.1456 -2.803 0.896 N 0.768 0.212 0.610115391599 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.93274E-04 None 0 0 0 0 0
I/T 26124 Fn3-78 37 rs778290450 0.1456 -2.803 0.896 N 0.768 0.212 0.610115391599 gnomAD-4.0.0 8.05796E-06 None None None None N None 0 6.67156E-05 None 0 2.23075E-05 None 0 0 6.78219E-06 0 0
I/V 26124 Fn3-78 37 rs397517713 0.067 None 0.004 N 0.232 0.069 0.385084120042 gnomAD-4.0.0 2.73743E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59844E-06 0 0
V/G 26323 Fn3-79 38 None 0.703 None 0.642 N 0.713 0.367 0.767911445349 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
V/I 26323 Fn3-79 38 None 0.0601 None 0.001 N 0.308 0.033 0.36893422563 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
I/L 26422 Fn3-80 37 rs1553590996 0.1378 None 0.63 N 0.479 0.207 0.559156356702 gnomAD-4.0.0 2.73732E-06 None None None None N None 0 0 None 0 1.00939E-04 None 0 0 0 0 0
I/T 26422 Fn3-80 37 rs3731745 0.2075 -2.683 0.983 N 0.671 0.404 None gnomAD-2.1.1 2.57346E-02 None None None None N None 4.85155E-03 3.35052E-02 None 1.46289E-02 6.12056E-02 None 6.04733E-03 None 4.7937E-02 2.33536E-02 2.65748E-02
I/T 26422 Fn3-80 37 rs3731745 0.2075 -2.683 0.983 N 0.671 0.404 None gnomAD-3.1.2 2.023E-02 None None None None N None 4.49189E-03 2.19131E-02 3.07018E-02 1.90311E-02 6.10465E-02 None 4.45974E-02 6.32911E-03 2.3392E-02 8.28844E-03 1.95985E-02
I/T 26422 Fn3-80 37 rs3731745 0.2075 -2.683 0.983 N 0.671 0.404 None 1000 genomes 2.23642E-02 None None None None N None 8E-04 2.45E-02 None None 6.05E-02 2.68E-02 None None None 6.1E-03 None
I/T 26422 Fn3-80 37 rs3731745 0.2075 -2.683 0.983 N 0.671 0.404 None gnomAD-4.0.0 2.28872E-02 None None None None N None 4.29448E-03 2.94029E-02 None 1.48689E-02 6.3117E-02 None 4.77173E-02 9.89772E-03 2.24368E-02 6.71981E-03 2.17106E-02
I/V 26422 Fn3-80 37 rs1553590996 0.0737 None 0.598 N 0.487 0.143 0.513337797588 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.3113E-04 0 0 0 None 0 0 0 0 0
I/V 26422 Fn3-80 37 rs1553590996 0.0737 None 0.598 N 0.487 0.143 0.513337797588 gnomAD-4.0.0 2.47925E-06 None None None None N None 0 3.336E-05 None 0 0 None 0 0 1.69539E-06 0 0
V/A 26523 Fn3-81 37 None 0.1473 None 0.001 N 0.319 0.206 0.606876268242 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 26719 Fn3-82 37 None 0.4703 None 0.517 N 0.541 0.335 0.501060295512 gnomAD-4.0.0 5.47426E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29688E-06 0 1.65684E-05
V/A 26816 Fn3-83 37 rs1177780119 0.1631 -1.992 0.183 N 0.399 0.192 0.568358697712 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 0 None 1.39224E-04 8.92E-06 0
V/A 26816 Fn3-83 37 rs1177780119 0.1631 -1.992 0.183 N 0.399 0.192 0.568358697712 gnomAD-4.0.0 1.1141E-05 None None None None N None 0 0 None 0 0 None 7.52927E-05 0 8.57746E-06 0 0
V/I 26816 Fn3-83 37 rs774092000 0.0671 -0.361 0.004 N 0.181 0.062 0.357929162469 gnomAD-2.1.1 3.63E-05 None None None None N None 0 8.69E-05 None 0 0 None 0 None 0 5.35E-05 0
V/I 26816 Fn3-83 37 rs774092000 0.0671 -0.361 0.004 N 0.181 0.062 0.357929162469 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 26816 Fn3-83 37 rs774092000 0.0671 -0.361 0.004 N 0.181 0.062 0.357929162469 gnomAD-4.0.0 1.42548E-05 None None None None N None 1.33554E-05 3.33456E-05 None 0 0 None 0 1.64474E-04 1.52588E-05 0 1.60169E-05
I/F 27009 Fn3-84 38 None 0.3888 None 0.942 N 0.681 0.338 0.566846708062 gnomAD-4.0.0 1.5918E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85935E-06 0 0
I/S 27009 Fn3-84 38 None 0.4889 None 0.942 N 0.65 0.486 0.738858788324 gnomAD-4.0.0 1.5918E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85932E-06 0 0
I/T 27009 Fn3-84 38 rs1408591294 0.2275 -2.993 0.822 N 0.676 0.429 0.645206814577 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/T 27009 Fn3-84 38 rs1408591294 0.2275 -2.993 0.822 N 0.676 0.429 0.645206814577 gnomAD-4.0.0 1.5918E-06 None None None None N None 0 2.28666E-05 None 0 0 None 0 0 0 0 0
I/V 27009 Fn3-84 38 rs763457498 0.0758 -1.819 0.006 N 0.245 0.088 0.399740851666 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 8.9E-06 0
I/V 27009 Fn3-84 38 rs763457498 0.0758 -1.819 0.006 N 0.245 0.088 0.399740851666 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.93274E-04 None 0 0 0 0 0
I/V 27009 Fn3-84 38 rs763457498 0.0758 -1.819 0.006 N 0.245 0.088 0.399740851666 gnomAD-4.0.0 5.12593E-06 None None None None N None 0 1.69526E-05 None 0 4.85225E-05 None 0 0 2.3938E-06 0 0
H/D 27108 Fn3-85 37 None 0.9315 None 0.99 N 0.661 0.427 0.366848117066 gnomAD-4.0.0 6.84658E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99798E-07 0 0
H/R 27108 Fn3-85 37 rs761773428 0.4601 -1.557 0.97 N 0.635 0.477 0.320256813643 gnomAD-2.1.1 1.22E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.71E-05 0
H/R 27108 Fn3-85 37 rs761773428 0.4601 -1.557 0.97 N 0.635 0.477 0.320256813643 gnomAD-4.0.0 1.11538E-05 None None None None N None 0 0 None 0 0 None 0 0 1.71665E-05 0 3.0292E-05
H/Y 27108 Fn3-85 37 None 0.1449 None 0.014 N 0.476 0.312 0.229264304666 gnomAD-4.0.0 6.84658E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16042E-05 0
I/T 27206 Fn3-86 37 rs369868913 0.1485 -2.929 None N 0.591 0.144 None gnomAD-2.1.1 1.44E-05 None None None None N None 4.16E-05 5.7E-05 None 0 0 None 0 None 0 7.92E-06 0
I/T 27206 Fn3-86 37 rs369868913 0.1485 -2.929 None N 0.591 0.144 None gnomAD-3.1.2 1.97E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 27206 Fn3-86 37 rs369868913 0.1485 -2.929 None N 0.591 0.144 None gnomAD-4.0.0 1.2402E-05 None None None None N None 2.67108E-05 3.34135E-05 None 0 0 None 0 0 1.3567E-05 0 0
I/V 27505 Fn3-88 37 rs1270467286 0.0877 None None N 0.283 0.052 0.244539031024 gnomAD-4.0.0 3.60098E-06 None None None None N None 1.26695E-04 0 None 0 0 None 0 6.17284E-04 0 0 0
V/A 27606 Fn3-89 37 rs1395661220 0.2653 -1.88 0.822 N 0.605 0.297 0.632854968478 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
V/I 27606 Fn3-89 37 rs777713575 0.061 -0.319 0.006 N 0.243 0.038 0.288352970974 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/T 27802 Fn3-90 37 rs887481991 0.2103 -2.73 0.984 N 0.611 0.418 0.691580264319 gnomAD-2.1.1 4.09E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.97E-06 0
I/T 27802 Fn3-90 37 rs887481991 0.2103 -2.73 0.984 N 0.611 0.418 0.691580264319 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/T 27802 Fn3-90 37 rs887481991 0.2103 -2.73 0.984 N 0.611 0.418 0.691580264319 gnomAD-4.0.0 3.87894E-06 None None None None N None 0 0 None 0 0 None 0 0 7.23795E-06 0 0
I/V 27802 Fn3-90 37 rs727504723 0.0693 -1.705 0.011 N 0.27 0.06 0.36076525451 gnomAD-2.1.1 4.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
I/V 27802 Fn3-90 37 rs727504723 0.0693 -1.705 0.011 N 0.27 0.06 0.36076525451 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 27802 Fn3-90 37 rs727504723 0.0693 -1.705 0.011 N 0.27 0.06 0.36076525451 gnomAD-4.0.0 1.30687E-05 None None None None N None 2.68579E-05 0 None 0 0 None 0 0 1.53002E-05 0 1.61077E-05
V/L 27899 Fn3-91 37 rs775678192 0.13 -0.734 0.164 N 0.39 0.064 0.483962474653 gnomAD-2.1.1 8.05E-06 None None None None N None 1.29282E-04 0 None 0 0 None 0 None 0 0 0
V/L 27899 Fn3-91 37 rs775678192 0.13 -0.734 0.164 N 0.39 0.064 0.483962474653 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
V/L 27899 Fn3-91 37 rs775678192 0.13 -0.734 0.164 N 0.39 0.064 0.483962474653 gnomAD-4.0.0 2.47947E-06 None None None None N None 5.34045E-05 0 None 0 0 None 0 0 0 0 0
I/T 28091 Fn3-92 37 None 0.1664 None 0.505 N 0.711 0.275 0.671345282208 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
I/V 28091 Fn3-92 37 rs886042615 0.0743 -2.07 None N 0.185 0.04 0.39843156188 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 0 0
I/V 28091 Fn3-92 37 rs886042615 0.0743 -2.07 None N 0.185 0.04 0.39843156188 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 28091 Fn3-92 37 rs886042615 0.0743 -2.07 None N 0.185 0.04 0.39843156188 gnomAD-4.0.0 3.71847E-06 None None None None N None 0 0 None 0 0 None 3.12471E-05 0 8.47626E-07 2.19578E-05 1.60138E-05
H/P 28190 Fn3-93 37 None 0.9916 None 0.99 N 0.765 0.556 0.589665606642 gnomAD-4.0.0 1.59244E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85981E-06 0 0
H/Q 28190 Fn3-93 37 None 0.8128 None 0.97 N 0.719 0.325 0.348983352498 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/R 28190 Fn3-93 37 rs1248103386 0.5705 -1.544 0.97 N 0.719 0.48 0.383089235449 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.61E-05 None 0 None 0 0 0
H/R 28190 Fn3-93 37 rs1248103386 0.5705 -1.544 0.97 N 0.719 0.48 0.383089235449 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
H/R 28190 Fn3-93 37 rs1248103386 0.5705 -1.544 0.97 N 0.719 0.48 0.383089235449 gnomAD-4.0.0 2.56354E-06 None None None None N None 1.69102E-05 0 None 0 2.43049E-05 None 0 0 0 0 0
H/Y 28190 Fn3-93 37 rs770757137 0.2482 0.17 0.014 N 0.47 0.374 0.257292322809 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
H/Y 28190 Fn3-93 37 rs770757137 0.2482 0.17 0.014 N 0.47 0.374 0.257292322809 gnomAD-4.0.0 1.59256E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02572E-05
I/L 28288 Fn3-94 37 None 0.1063 None 0.002 N 0.289 0.106 0.507510703362 gnomAD-4.0.0 6.84213E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99446E-07 0 0
I/N 28288 Fn3-94 37 None 0.3218 None 0.975 N 0.776 0.453 0.807978538823 gnomAD-4.0.0 6.84225E-07 None None None None N None 0 2.23614E-05 None 0 0 None 0 0 0 0 0
I/T 28288 Fn3-94 37 None 0.1313 None 0.864 N 0.655 0.431 0.678712887374 gnomAD-4.0.0 4.10535E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7989E-06 2.31868E-05 3.31301E-05
I/V 28288 Fn3-94 37 rs775883370 0.067 -1.433 0.141 N 0.412 0.069 0.417334834585 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
I/V 28288 Fn3-94 37 rs775883370 0.067 -1.433 0.141 N 0.412 0.069 0.417334834585 gnomAD-4.0.0 8.89476E-06 None None None None N None 0 0 None 0 0 None 0 0 1.16928E-05 0 0
I/V 28487 Fn3-95 38 rs375122794 0.0715 None 0.006 N 0.28 0.035 0.527809512145 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/K 28586 Fn3-96 37 rs773336002 0.562 -2.549 0.773 N 0.731 0.372 0.72415221971 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
I/K 28586 Fn3-96 37 rs773336002 0.562 -2.549 0.773 N 0.731 0.372 0.72415221971 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/K 28586 Fn3-96 37 rs773336002 0.562 -2.549 0.773 N 0.731 0.372 0.72415221971 gnomAD-4.0.0 3.04486E-06 None None None None N None 5.24146E-05 0 None 0 0 None 0 0 0 0 0
I/L 28586 Fn3-96 37 None 0.1148 None 0.001 N 0.259 0.086 0.377799810692 gnomAD-4.0.0 3.42126E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49738E-06 0 0
I/V 28586 Fn3-96 37 rs1187128207 0.0674 None None N 0.202 0.072 0.312306559268 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 28586 Fn3-96 37 rs1187128207 0.0674 None None N 0.202 0.072 0.312306559268 gnomAD-4.0.0 2.47889E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39044E-06 0 0
H/D 28881 Fn3-98 37 None 0.4412 None 0.351 N 0.572 0.314 0.18274738541 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 1.94099E-04 0 None 0 0 0 0 0
V/A 28978 Fn3-99 37 None 0.1623 None 0.052 N 0.511 0.178 0.671759834441 gnomAD-4.0.0 6.15797E-06 None None None None N None 0 0 None 0 0 None 0 0 8.09507E-06 0 0
I/V 29174 Fn3-100 38 rs1309415866 0.094 None 0.993 N 0.436 0.186 0.503559190036 gnomAD-4.0.0 1.59103E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85785E-06 0 0
H/D 29273 Fn3-101 37 None 0.9181 None 1.0 N 0.728 0.474 0.459906663326 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/Q 29273 Fn3-101 37 None 0.6291 None 1.0 N 0.77 0.298 0.378674557249 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/R 29273 Fn3-101 37 rs1218145435 0.3977 -1.75 1.0 N 0.748 0.518 0.414670632993 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
H/R 29273 Fn3-101 37 rs1218145435 0.3977 -1.75 1.0 N 0.748 0.518 0.414670632993 gnomAD-4.0.0 3.18205E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8578E-06 1.43271E-05 0
I/F 29371 Fn3-102 37 None 0.1508 None 0.001 N 0.499 0.222 0.499345284858 gnomAD-4.0.0 1.59143E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85801E-06 0 0
I/N 29371 Fn3-102 37 rs767890385 0.2981 -2.083 0.484 N 0.699 0.311 0.72990446813 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
I/N 29371 Fn3-102 37 rs767890385 0.2981 -2.083 0.484 N 0.699 0.311 0.72990446813 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/N 29371 Fn3-102 37 rs767890385 0.2981 -2.083 0.484 N 0.699 0.311 0.72990446813 gnomAD-4.0.0 1.85912E-06 None None None None N None 2.66937E-05 0 None 0 0 None 0 0 8.47571E-07 0 0
I/T 29371 Fn3-102 37 rs767890385 0.1205 -2.296 0.117 N 0.665 0.183 None gnomAD-2.1.1 4.02E-05 None None None None N None 6.46E-05 1.73974E-04 None 0 5.61E-05 None 3.27E-05 None 0 8.89E-06 0
I/T 29371 Fn3-102 37 rs767890385 0.1205 -2.296 0.117 N 0.665 0.183 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
I/T 29371 Fn3-102 37 rs767890385 0.1205 -2.296 0.117 N 0.665 0.183 None gnomAD-4.0.0 2.5408E-05 None None None None N None 2.66937E-05 1.16706E-04 None 0 0 None 0 0 2.62747E-05 1.09798E-05 0
I/V 29371 Fn3-102 37 rs1229603276 0.0701 -1.081 None N 0.259 0.073 0.313210971179 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
I/V 29371 Fn3-102 37 rs1229603276 0.0701 -1.081 None N 0.259 0.073 0.313210971179 gnomAD-4.0.0 3.18286E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 2.85801E-06 0 0
I/L 29570 Fn3-103 38 rs139506970 0.1653 None 0.58 N 0.418 0.061 0.549964211903 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.30993E-04 0 0 0 None 0 0 0 0 0
I/L 29570 Fn3-103 38 rs139506970 0.1653 None 0.58 N 0.418 0.061 0.549964211903 gnomAD-4.0.0 1.85903E-06 None None None None N None 0 5.00067E-05 None 0 0 None 0 0 0 0 0
I/T 29570 Fn3-103 38 rs965795447 0.1546 -3.327 0.939 N 0.675 0.391 0.680584855444 gnomAD-2.1.1 6.37E-05 None None None None N None 2.29463E-04 0 None 0 0 None 0 None 0 0 0
I/T 29570 Fn3-103 38 rs965795447 0.1546 -3.327 0.939 N 0.675 0.391 0.680584855444 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
I/T 29570 Fn3-103 38 rs965795447 0.1546 -3.327 0.939 N 0.675 0.391 0.680584855444 gnomAD-4.0.0 4.06004E-06 None None None None N None 6.99252E-05 0 None 0 0 None 0 0 0 0 0
I/V 29570 Fn3-103 38 rs139506970 0.0638 -2.338 0.02 N 0.233 0.041 None gnomAD-2.1.1 8.24753E-04 None None None None N None 8.63565E-03 1.41411E-04 None 0 0 None 3.27E-05 None 0 1.01613E-04 4.20994E-04
I/V 29570 Fn3-103 38 rs139506970 0.0638 -2.338 0.02 N 0.233 0.041 None gnomAD-3.1.2 2.43258E-03 None None None None N None 8.28062E-03 8.51454E-04 0 0 0 None 0 0 1.32326E-04 2.07297E-04 1.91205E-03
I/V 29570 Fn3-103 38 rs139506970 0.0638 -2.338 0.02 N 0.233 0.041 None 1000 genomes 3.39457E-03 None None None None N None 1.21E-02 1.4E-03 None None 0 0 None None None 0 None
I/V 29570 Fn3-103 38 rs139506970 0.0638 -2.338 0.02 N 0.233 0.041 None gnomAD-4.0.0 5.00663E-04 None None None None N None 8.45085E-03 3.9992E-04 None 0 0 None 0 2.30947E-03 6.78065E-05 3.29388E-05 8.48217E-04
F/S 29669 Fn3-104 37 None 0.3594 None 0.055 N 0.605 0.216 0.317378411342 gnomAD-4.0.0 1.59111E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85794E-06 0 0
V/A 29770 Fn3-105 37 rs755018367 0.1546 -1.872 None N 0.258 0.077 0.392855499163 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 9.96E-05 0 None 0 None 0 3.56E-05 0
V/A 29770 Fn3-105 37 rs755018367 0.1546 -1.872 None N 0.258 0.077 0.392855499163 gnomAD-3.1.2 3.94E-05 None None None None N None 2.41E-05 0 0 2.88018E-04 0 None 0 0 5.88E-05 0 0
V/A 29770 Fn3-105 37 rs755018367 0.1546 -1.872 None N 0.258 0.077 0.392855499163 gnomAD-4.0.0 1.85908E-05 None None None None N None 1.33465E-05 0 None 6.75676E-05 0 None 0 0 2.11899E-05 0 3.20236E-05
V/A 29969 Fn3-106 37 rs201220828 0.4703 -2.696 0.104 N 0.617 0.226 None gnomAD-2.1.1 1.44E-05 None None None None N None 1.6544E-04 0 None 0 0 None 0 None 0 0 0
V/A 29969 Fn3-106 37 rs201220828 0.4703 -2.696 0.104 N 0.617 0.226 None gnomAD-3.1.2 3.29E-05 None None None None N None 1.20627E-04 0 0 0 0 None 0 0 0 0 0
V/A 29969 Fn3-106 37 rs201220828 0.4703 -2.696 0.104 N 0.617 0.226 None gnomAD-4.0.0 5.58327E-06 None None None None N None 9.34255E-05 0 None 0 0 None 0 0 0 0 3.20297E-05
V/I 29969 Fn3-106 37 None 0.0664 None None N 0.236 0.069 0.262662153117 gnomAD-4.0.0 1.59595E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85829E-06 0 0
V/A 30066 Fn3-107 37 rs1011515969 0.1951 -1.87 0.027 N 0.566 0.19 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
V/A 30066 Fn3-107 37 rs1011515969 0.1951 -1.87 0.027 N 0.566 0.19 None gnomAD-4.0.0 3.42086E-06 None None None None N None 2.98721E-05 0 None 0 0 None 0 0 2.6983E-06 0 1.6564E-05
V/I 30066 Fn3-107 37 rs1166369536 0.0677 None None N 0.21 0.061 0.209622950755 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 2.88184E-04 0 None 0 0 0 0 0
V/I 30066 Fn3-107 37 rs1166369536 0.0677 None None N 0.21 0.061 0.209622950755 gnomAD-4.0.0 6.57065E-06 None None None None N None 0 0 None 2.88184E-04 0 None 0 0 0 0 0
S/G 30261 Fn3-108 38 None 0.3215 None 0.994 N 0.547 0.275 0.300784259202 gnomAD-4.0.0 3.18256E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71651E-06 0 0
S/I 30261 Fn3-108 38 None 0.315 None 0.998 N 0.658 0.365 0.384919354899 gnomAD-4.0.0 6.84236E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99488E-07 0 0
S/T 30261 Fn3-108 38 None 0.1398 None 0.994 N 0.545 0.238 0.227260227426 gnomAD-4.0.0 2.05271E-06 None None None None I None 0 0 None 0 0 None 0 0 0 3.47923E-05 0
H/R 30360 Fn3-109 37 None 0.2434 None 0.879 N 0.652 0.3 0.21279746466 gnomAD-4.0.0 1.59114E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85806E-06 0 0
H/Y 30360 Fn3-109 37 rs1033418419 0.0798 None 0.003 N 0.506 0.092 0.18274738541 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
S/G 30458 Fn3-110 37 None 0.1749 None 0.565 N 0.667 0.142 0.235038932564 gnomAD-4.0.0 1.5918E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85922E-06 0 0
S/N 30458 Fn3-110 37 rs376634713 0.2003 -1.264 0.008 N 0.499 0.044 None gnomAD-2.1.1 7.86E-05 None None None None N None 8.27E-05 1.13282E-04 None 0 0 None 0 None 0 1.17308E-04 1.40489E-04
S/N 30458 Fn3-110 37 rs376634713 0.2003 -1.264 0.008 N 0.499 0.044 None gnomAD-3.1.2 8.55E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 1.47003E-04 0 0
S/N 30458 Fn3-110 37 rs376634713 0.2003 -1.264 0.008 N 0.499 0.044 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
S/N 30458 Fn3-110 37 rs376634713 0.2003 -1.264 0.008 N 0.499 0.044 None gnomAD-4.0.0 7.80872E-05 None None None None N None 3.99947E-05 1.1669E-04 None 0 0 None 0 0 9.49416E-05 0 6.40348E-05
S/R 30458 Fn3-110 37 rs762232248 0.8989 -0.73 0.901 N 0.708 0.227 0.279776271856 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
S/R 30458 Fn3-110 37 rs762232248 0.8989 -0.73 0.901 N 0.708 0.227 0.279776271856 gnomAD-4.0.0 3.18366E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86574E-05 0
I/N 30656 Fn3-111 38 rs775922403 0.2551 -2.597 0.295 N 0.647 0.222 0.722529336234 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
I/N 30656 Fn3-111 38 rs775922403 0.2551 -2.597 0.295 N 0.647 0.222 0.722529336234 gnomAD-4.0.0 2.05272E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69851E-06 0 0
I/S 30656 Fn3-111 38 None 0.2676 None 0.029 N 0.587 0.319 0.754515611653 gnomAD-4.0.0 1.16321E-05 None None None None N None 0 0 None 0 0 None 0 0 1.4392E-05 0 1.65662E-05
I/V 30656 Fn3-111 38 rs886043632 0.0593 None None N 0.151 0.069 0.352048277211 gnomAD-4.0.0 1.59144E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02425E-05
V/A 31052 Fn3-114 37 None 0.2423 None 0.472 N 0.527 0.204 0.574126200305 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/L 31052 Fn3-114 37 None 0.1573 None 0.063 N 0.388 0.089 0.377451072189 gnomAD-4.0.0 6.84178E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99442E-07 0 0
V/M 31052 Fn3-114 37 rs764170998 0.1193 -0.972 0.078 N 0.43 0.172 0.4018988957 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.67E-05 0
V/M 31052 Fn3-114 37 rs764170998 0.1193 -0.972 0.078 N 0.43 0.172 0.4018988957 gnomAD-4.0.0 4.78925E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49721E-06 1.15931E-05 1.65645E-05
L/V 31149 Fn3-115 37 None 0.0665 None 0.248 N 0.377 0.063 0.424073947737 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/T 31345 Fn3-116 38 rs1297026884 0.5622 None 1.0 N 0.687 0.425 0.684588293173 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 31345 Fn3-116 38 rs756013336 0.1123 -1.511 0.993 N 0.409 0.235 0.545389625809 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/V 31345 Fn3-116 38 rs756013336 0.1123 -1.511 0.993 N 0.409 0.235 0.545389625809 gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
I/V 31345 Fn3-116 38 rs756013336 0.1123 -1.511 0.993 N 0.409 0.235 0.545389625809 gnomAD-4.0.0 6.81629E-06 None None None None N None 5.33846E-05 0 None 0 0 None 0 0 5.08548E-06 1.09789E-05 0
W/C 31444 Fn3-117 37 rs1697578690 0.7723 None 1.0 N 0.797 0.388 0.507928266286 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
W/C 31444 Fn3-117 37 rs1697578690 0.7723 None 1.0 N 0.797 0.388 0.507928266286 gnomAD-4.0.0 6.57289E-06 None None None None N None 2.41406E-05 0 None 0 0 None 0 0 0 0 0
W/R 31444 Fn3-117 37 rs533447102 0.9399 -1.794 1.0 N 0.839 0.5 0.630156806279 gnomAD-2.1.1 5.62E-05 None None None None N None 6.46E-05 0 None 0 0 None 3.92131E-04 None 0 0 1.65508E-04
W/R 31444 Fn3-117 37 rs533447102 0.9399 -1.794 1.0 N 0.839 0.5 0.630156806279 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 4.14422E-04 0
W/R 31444 Fn3-117 37 rs533447102 0.9399 -1.794 1.0 N 0.839 0.5 0.630156806279 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
W/R 31444 Fn3-117 37 rs533447102 0.9399 -1.794 1.0 N 0.839 0.5 0.630156806279 gnomAD-4.0.0 2.23073E-05 None None None None N None 2.66581E-05 0 None 0 0 None 0 0 1.69523E-06 3.4036E-04 1.60067E-05
I/V 31744 Fn3-119 37 rs749403545 0.071 -1.62 0.016 N 0.243 0.029 0.372087925617 gnomAD-2.1.1 1.61E-05 None None None None I None 6.46E-05 2.9E-05 None 0 0 None 0 None 0 1.78E-05 0
I/V 31744 Fn3-119 37 rs749403545 0.071 -1.62 0.016 N 0.243 0.029 0.372087925617 gnomAD-3.1.2 1.31E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 31744 Fn3-119 37 rs749403545 0.071 -1.62 0.016 N 0.243 0.029 0.372087925617 gnomAD-4.0.0 9.29536E-06 None None None None I None 2.66951E-05 1.66678E-05 None 0 0 None 0 0 1.01713E-05 0 0
L/P 31843 Fn3-120 37 rs1696696732 0.9875 None 0.997 N 0.784 0.626 0.582449840715 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07469E-04 0
L/P 31843 Fn3-120 37 rs1696696732 0.9875 None 0.997 N 0.784 0.626 0.582449840715 gnomAD-4.0.0 6.57376E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07469E-04 0
L/R 31843 Fn3-120 37 None 0.3608 None 0.997 N 0.753 0.57 0.461323234107 gnomAD-4.0.0 1.5914E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
V/I 31945 Fn3-121 37 None 0.0686 None 0.37 N 0.294 0.166 0.383256108077 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
I/L 32141 Fn3-122 37 None 0.303 None 0.983 N 0.409 0.171 0.593771126905 gnomAD-4.0.0 6.85147E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15966E-05 0
I/N 32141 Fn3-122 37 rs753559586 0.9117 None 1.0 N 0.795 0.512 0.828995217034 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/N 32141 Fn3-122 37 rs753559586 0.9117 None 1.0 N 0.795 0.512 0.828995217034 gnomAD-4.0.0 4.05964E-06 None None None None N None 1.74672E-05 0 None 0 0 None 0 0 3.61476E-06 0 0
I/V 32141 Fn3-122 37 rs794729249 0.0855 None 0.987 N 0.419 0.115 0.554518586217 gnomAD-4.0.0 8.90692E-06 None None None None N None 0 0 None 0 2.52258E-05 None 0 0 8.99518E-06 0 3.31488E-05
V/A 32238 Fn3-123 37 None 0.3834 None 0.822 N 0.665 0.234 0.610312411291 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/L 32238 Fn3-123 37 rs758769330 0.1753 -0.387 0.014 N 0.434 0.106 0.435262743402 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
V/L 32238 Fn3-123 37 rs758769330 0.1753 -0.387 0.014 N 0.434 0.106 0.435262743402 gnomAD-4.0.0 1.59113E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85812E-06 0 0
I/M 32535 Fn3-125 37 rs760676361 0.1077 -1.245 1.0 N 0.747 0.25 0.539612970712 gnomAD-2.1.1 2.14E-05 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 3.13E-05 0
I/M 32535 Fn3-125 37 rs760676361 0.1077 -1.245 1.0 N 0.747 0.25 0.539612970712 gnomAD-3.1.2 1.97E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 0 0
I/M 32535 Fn3-125 37 rs760676361 0.1077 -1.245 1.0 N 0.747 0.25 0.539612970712 gnomAD-4.0.0 4.89659E-05 None None None None N None 4.00652E-05 0 None 0 0 None 0 0 6.3581E-05 0 1.60169E-05
I/T 32535 Fn3-125 37 rs2154141649 0.2052 None 1.0 N 0.701 0.475 0.731403993514 gnomAD-4.0.0 1.36871E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.15977E-05 1.65717E-05
L/F 32636 Fn3-126 37 rs767660102 0.2076 -1.647 0.998 N 0.769 0.182 0.539970339866 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
L/F 32636 Fn3-126 37 rs767660102 0.2076 -1.647 0.998 N 0.769 0.182 0.539970339866 gnomAD-4.0.0 1.59117E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85822E-06 0 0
Y/H 32933 Fn3-128 38 rs775150547 0.3592 -2.157 1.0 N 0.765 0.368 None gnomAD-2.1.1 1.07E-05 None None None None N None 1.24008E-04 0 None 0 0 None 0 None 0 0 0
Y/H 32933 Fn3-128 38 rs775150547 0.3592 -2.157 1.0 N 0.765 0.368 None gnomAD-3.1.2 3.29E-05 None None None None N None 1.20651E-04 0 0 0 0 None 0 0 0 0 0
Y/H 32933 Fn3-128 38 rs775150547 0.3592 -2.157 1.0 N 0.765 0.368 None gnomAD-4.0.0 7.68699E-06 None None None None N None 1.01492E-04 0 None 0 0 None 0 0 0 0 0
W/C 33034 Fn3-129 37 rs397517778 0.8004 -1.512 1.0 N 0.783 0.365 0.568143352941 gnomAD-2.1.1 2.42518E-04 None None None None N None 0 2.83E-05 None 0 3.43062E-03 None 0 None 0 0 0
W/C 33034 Fn3-129 37 rs397517778 0.8004 -1.512 1.0 N 0.783 0.365 0.568143352941 gnomAD-3.1.2 7.89E-05 None None None None N None 0 0 0 0 2.12028E-03 None 0 0 0 0 4.78927E-04
W/C 33034 Fn3-129 37 rs397517778 0.8004 -1.512 1.0 N 0.783 0.365 0.568143352941 1000 genomes 1.19808E-03 None None None None N None 0 0 None None 6E-03 0 None None None 0 None
W/C 33034 Fn3-129 37 rs397517778 0.8004 -1.512 1.0 N 0.783 0.365 0.568143352941 gnomAD-4.0.0 6.07289E-05 None None None None N None 0 0 None 0 2.02817E-03 None 0 0 0 0 1.12039E-04
W/R 33034 Fn3-129 37 None 0.893 None 1.0 N 0.812 0.511 0.697679765967 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
W/S 33034 Fn3-129 37 rs786205365 0.6133 None 1.0 N 0.793 0.39 0.758254570115 gnomAD-4.0.0 2.7369E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79898E-06 2.31884E-05 0
V/L 33327 Fn3-130 38 rs1219652014 0.4763 -0.911 0.099 N 0.434 0.113 0.400756358115 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
V/L 33327 Fn3-130 38 rs1219652014 0.4763 -0.911 0.099 N 0.434 0.113 0.400756358115 gnomAD-4.0.0 1.59208E-06 None None None None N None 0 2.28948E-05 None 0 0 None 0 0 0 0 0
Y/H 33428 Fn3-131 37 rs766455406 0.136 -1.67 0.983 N 0.64 0.368 0.331619326243 gnomAD-2.1.1 3.18E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
Y/N 33428 Fn3-131 37 rs766455406 0.2046 -2.381 0.983 N 0.732 0.548 0.608268572844 gnomAD-2.1.1 4.2E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.22E-06 0
Y/N 33428 Fn3-131 37 rs766455406 0.2046 -2.381 0.983 N 0.732 0.548 0.608268572844 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Y/N 33428 Fn3-131 37 rs766455406 0.2046 -2.381 0.983 N 0.732 0.548 0.608268572844 gnomAD-4.0.0 1.31106E-05 None None None None I None 0 0 None 0 0 None 0 0 1.78958E-05 0 0
I/F 33725 Fn3-132 37 None 0.4135 None 0.999 D 0.704 0.366 0.629718971361 gnomAD-4.0.0 6.84188E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99441E-07 0 0
I/T 33725 Fn3-132 37 rs1329737429 0.4143 -2.815 0.46 N 0.524 0.231 0.618703310563 gnomAD-2.1.1 7.14E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.56E-05 0
I/T 33725 Fn3-132 37 rs1329737429 0.4143 -2.815 0.46 N 0.524 0.231 0.618703310563 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/T 33725 Fn3-132 37 rs1329737429 0.4143 -2.815 0.46 N 0.524 0.231 0.618703310563 gnomAD-4.0.0 5.57685E-06 None None None None N None 0 1.66667E-05 None 0 0 None 0 1.64366E-04 5.08544E-06 0 1.60108E-05
I/V 33725 Fn3-132 37 rs878900245 0.1062 -1.741 0.425 N 0.395 0.182 None gnomAD-2.1.1 1.21E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 1.77E-05 0
I/V 33725 Fn3-132 37 rs878900245 0.1062 -1.741 0.425 N 0.395 0.182 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 33725 Fn3-132 37 rs878900245 0.1062 -1.741 0.425 N 0.395 0.182 None gnomAD-4.0.0 1.92088E-05 None None None None N None 1.3344E-05 1.66672E-05 None 0 0 None 0 0 2.37319E-05 0 1.60092E-05

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.