Structural position:

  • Domain Type: Fn3
  • Aligned Position: 41
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand C

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
E/K 15796 Fn3-2 39 rs2057656549 0.9718 None 0.992 D 0.639 0.44 0.359763055319 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
E/K 15796 Fn3-2 39 rs2057656549 0.9718 None 0.992 D 0.639 0.44 0.359763055319 gnomAD-4.0.0 6.58553E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07211E-04 0
E/A 15897 Fn3-3 39 rs1307467138 0.7714 None 0.996 D 0.721 0.557 0.507331908393 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.95236E-04 None 0 0 0 0 0
E/A 15897 Fn3-3 39 rs1307467138 0.7714 None 0.996 D 0.721 0.557 0.507331908393 gnomAD-4.0.0 6.58389E-06 None None None None N None 0 0 None 0 1.95236E-04 None 0 0 0 0 0
E/K 15897 Fn3-3 39 rs746794275 0.7606 -1.765 0.992 D 0.66 0.474 0.444807159249 gnomAD-2.1.1 4.55E-06 None None None None N None 0 0 None 0 0 None 4.03E-05 None 0 0 0
E/K 15897 Fn3-3 39 rs746794275 0.7606 -1.765 0.992 D 0.66 0.474 0.444807159249 gnomAD-4.0.0 1.65081E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.55487E-05 0
E/Q 16093 Fn3-4 39 rs1320775896 0.3678 -1.362 0.01 N 0.357 0.145 0.134241683229 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
E/Q 16093 Fn3-4 39 rs1320775896 0.3678 -1.362 0.01 N 0.357 0.145 0.134241683229 gnomAD-4.0.0 1.59429E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86457E-06 0 0
E/D 16389 Fn3-6 39 rs1386540651 0.7144 -1.717 0.999 D 0.645 0.307 0.260249123532 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/D 16389 Fn3-6 39 rs1386540651 0.7144 -1.717 0.999 D 0.645 0.307 0.260249123532 gnomAD-4.0.0 1.36931E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31949E-05 0
E/K 16389 Fn3-6 39 rs2154201588 0.9275 None 0.999 D 0.682 0.46 0.390060412749 gnomAD-4.0.0 4.10788E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69936E-06 0 4.97595E-05
E/K 16789 Fn3-10 39 rs762522321 0.9653 -1.738 0.999 D 0.672 0.414 0.400899426204 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
E/K 16789 Fn3-10 39 rs762522321 0.9653 -1.738 0.999 D 0.672 0.414 0.400899426204 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 16789 Fn3-10 39 rs762522321 0.9653 -1.738 0.999 D 0.672 0.414 0.400899426204 gnomAD-4.0.0 3.85512E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19297E-06 0 0
E/Q 16789 Fn3-10 39 rs762522321 0.7776 -1.563 1.0 N 0.739 0.362 0.32306181527 gnomAD-2.1.1 4.06E-06 None None None None N None 6.49E-05 0 None 0 0 None 0 None 0 0 0
E/Q 16789 Fn3-10 39 rs762522321 0.7776 -1.563 1.0 N 0.739 0.362 0.32306181527 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/Q 16789 Fn3-10 39 rs762522321 0.7776 -1.563 1.0 N 0.739 0.362 0.32306181527 gnomAD-4.0.0 6.57981E-06 None None None None N None 2.41394E-05 0 None 0 0 None 0 0 0 0 0
E/A 16890 Fn3-11 39 rs752204728 0.9791 -2.321 0.999 D 0.729 0.566 None gnomAD-2.1.1 1.85649E-04 None None None None N None 0 1.30586E-03 None 0 0 None 0 None 0 0 1.66168E-04
E/A 16890 Fn3-11 39 rs752204728 0.9791 -2.321 0.999 D 0.729 0.566 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 2.62226E-04 0 0 0 None 0 0 0 0 0
E/A 16890 Fn3-11 39 rs752204728 0.9791 -2.321 0.999 D 0.729 0.566 None gnomAD-4.0.0 7.30942E-05 None None None None N None 0 9.1572E-04 None 0 0 None 0 0 0 0 8.54311E-05
E/K 16890 Fn3-11 39 None 0.9927 None 0.999 D 0.676 0.516 0.488337271218 gnomAD-4.0.0 1.59284E-06 None None None None N None 0 2.2876E-05 None 0 0 None 0 0 0 0 0
E/Q 17185 Fn3-13 39 None 0.9305 None 1.0 N 0.759 0.348 0.359963025489 gnomAD-4.0.0 1.59266E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43332E-05 0
E/G 17407 Fn3-14 39 None 0.9516 None 1.0 D 0.803 0.473 0.567170738818 gnomAD-4.0.0 1.59376E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8619E-06 0 0
E/G 17507 Fn3-15 38 None 0.982 None 1.0 D 0.751 0.564 0.481690325388 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/H 17607 Fn3-16 39 rs1381094642 0.2036 -0.903 0.638 N 0.799 0.248 0.203808441222 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.61E-05 None 0 None 0 0 0
E/D 17802 Fn3-17 39 None 0.9313 None 0.998 N 0.605 0.291 0.251116650651 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
E/G 17802 Fn3-17 39 None 0.9642 None 0.999 D 0.746 0.405 0.563062970572 gnomAD-4.0.0 1.59287E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86151E-06 0 0
E/Q 17900 Fn3-18 39 rs1231539821 0.7256 None 0.997 N 0.777 0.218 0.276898752692 gnomAD-3.1.2 6.63E-06 None None None None N None 0 0 0 0 0 None 0 0 1.48E-05 0 0
E/Q 17900 Fn3-18 39 rs1231539821 0.7256 None 0.997 N 0.777 0.218 0.276898752692 gnomAD-4.0.0 6.6306E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47658E-05 0 0
D/G 18103 Fn3-19 39 None 0.6661 None 0.939 N 0.712 0.461 0.242244723065 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
D/N 18103 Fn3-19 39 rs1193175329 0.3727 None 0.939 N 0.702 0.265 0.215109475489 gnomAD-4.0.0 1.36959E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80013E-06 0 0
E/G 18204 Fn3-20 39 rs778173480 0.9509 -1.901 0.946 N 0.761 0.415 None gnomAD-4.0.0 1.5949E-05 None None None None N None 0 0 None 0 0 None 1.14025E-04 0 5.7262E-06 0 6.06796E-05
E/Q 18204 Fn3-20 39 rs749849370 0.7583 -1.274 0.716 N 0.725 0.32 0.260249123532 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
E/Q 18204 Fn3-20 39 rs749849370 0.7583 -1.274 0.716 N 0.725 0.32 0.260249123532 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/Q 18204 Fn3-20 39 rs749849370 0.7583 -1.274 0.716 N 0.725 0.32 0.260249123532 gnomAD-4.0.0 6.82064E-06 None None None None N None 0 1.66817E-05 None 0 0 None 0 0 7.63237E-06 1.09888E-05 0
E/V 18204 Fn3-20 39 rs778173480 0.96 None 0.946 N 0.793 0.532 0.539970339866 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
E/V 18204 Fn3-20 39 rs778173480 0.96 None 0.946 N 0.793 0.532 0.539970339866 gnomAD-4.0.0 1.59476E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86303E-06 0 0
E/D 18617 Fn3-23 39 rs878854316 0.6316 None 0.999 N 0.67 0.291 0.233150807113 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
E/D 18617 Fn3-23 39 rs878854316 0.6316 None 0.999 N 0.67 0.291 0.233150807113 gnomAD-4.0.0 2.0537E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 4.97166E-05
E/G 18617 Fn3-23 39 None 0.9448 None 1.0 D 0.746 0.546 0.680383660926 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
E/V 18617 Fn3-23 39 None 0.9716 None 1.0 N 0.751 0.558 0.756058230077 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 18823 Fn3-24 40 rs745380159 0.7323 -2.381 0.998 N 0.682 0.419 0.392702134506 gnomAD-2.1.1 7.22E-06 None None None None N None 4.15E-05 0 None 0 0 None 3.32E-05 None 0 0 0
E/K 18823 Fn3-24 40 rs745380159 0.7323 -2.381 0.998 N 0.682 0.419 0.392702134506 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/K 18823 Fn3-24 40 rs745380159 0.7323 -2.381 0.998 N 0.682 0.419 0.392702134506 gnomAD-4.0.0 1.02963E-05 None None None None N None 1.69693E-05 0 None 0 0 None 0 4.5045E-04 0 6.77287E-05 0
E/D 18922 Fn3-25 39 rs776653576 0.8966 None 0.999 N 0.656 0.272 0.443388199986 gnomAD-4.0.0 1.59327E-06 None None None None N None 5.66187E-05 0 None 0 0 None 0 0 0 0 0
E/G 18922 Fn3-25 39 rs761707154 0.9801 -1.888 1.0 D 0.753 0.589 None gnomAD-4.0.0 7.65409E-05 None None None None N None 0 0 None 0 0 None 7.80239E-04 0 8.58212E-06 0 1.2133E-04
E/D 19026 Fn3-26 39 None 0.8361 None 0.999 N 0.654 0.21 0.30212335484 gnomAD-4.0.0 1.60275E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86666E-06 0 0
E/Q 19026 Fn3-26 39 rs794727393 0.6671 None 1.0 D 0.762 0.294 0.282179105231 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07383E-04 0
E/Q 19026 Fn3-26 39 rs794727393 0.6671 None 1.0 D 0.762 0.294 0.282179105231 gnomAD-4.0.0 4.35069E-06 None None None None N None 0 0 None 0 0 None 0 0 0 7.81355E-05 0
E/A 19222 Fn3-27 40 None 0.8809 None 0.41 N 0.68 0.457 0.392855499163 gnomAD-4.0.0 6.86457E-07 None None None None N None 2.99133E-05 0 None 0 0 None 0 0 0 0 0
E/G 19222 Fn3-27 40 rs572862573 0.9192 -2.764 0.83 N 0.781 0.475 0.48763082235 gnomAD-2.1.1 7.07E-05 None None None None N None 0 0 None 0 0 None 5.16636E-04 None 0 0 3.39443E-04
E/G 19222 Fn3-27 40 rs572862573 0.9192 -2.764 0.83 N 0.781 0.475 0.48763082235 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07383E-04 0
E/G 19222 Fn3-27 40 rs572862573 0.9192 -2.764 0.83 N 0.781 0.475 0.48763082235 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
E/G 19222 Fn3-27 40 rs572862573 0.9192 -2.764 0.83 N 0.781 0.475 0.48763082235 gnomAD-4.0.0 2.85905E-05 None None None None N None 0 0 None 0 0 None 0 1.65125E-04 8.49117E-07 4.67873E-04 3.20821E-05
E/K 19222 Fn3-27 40 rs2051376296 0.925 None 0.41 N 0.673 0.256 0.263612267334 gnomAD-4.0.0 6.86556E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01237E-07 0 0
E/V 19222 Fn3-27 40 rs572862573 0.9334 -1.177 0.83 N 0.808 0.497 0.619387179241 gnomAD-2.1.1 4.16E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.19E-06 0
E/V 19222 Fn3-27 40 rs572862573 0.9334 -1.177 0.83 N 0.808 0.497 0.619387179241 gnomAD-4.0.0 6.86457E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.66041E-05
E/G 19322 Fn3-28 39 rs2050988778 0.9681 None 1.0 D 0.801 0.548 0.539835882356 gnomAD-4.0.0 1.44039E-05 None None None None N None 0 0 None 0 0 None 0 0 1.575E-05 0 0
E/Q 19322 Fn3-28 39 None 0.7112 None 1.0 D 0.755 0.403 0.383760037723 gnomAD-4.0.0 1.59222E-06 None None None None N None 0 0 None 0 2.77793E-05 None 0 0 0 0 0
E/D 19518 Fn3-29 40 rs747066203 0.6911 -2.09 0.999 N 0.649 0.345 0.295974979623 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.62E-05 None 0 None 0 0 0
E/D 19518 Fn3-29 40 rs747066203 0.6911 -2.09 0.999 N 0.649 0.345 0.295974979623 gnomAD-4.0.0 6.84383E-07 None None None None N None 0 0 None 0 2.52755E-05 None 0 0 0 0 0
E/K 19518 Fn3-29 40 rs1329313961 0.854 -2.384 0.999 N 0.686 0.377 0.489243007833 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/K 19518 Fn3-29 40 rs1329313961 0.854 -2.384 0.999 N 0.686 0.377 0.489243007833 gnomAD-4.0.0 1.59227E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43308E-05 0
E/K 19616 Fn3-30 38 None 0.9562 None 0.999 N 0.687 0.446 0.474643619859 gnomAD-4.0.0 3.60098E-06 None None None None N None 0 0 None 0 0 None 0 0 3.93752E-06 0 0
E/K 19718 Fn3-31 39 None 0.8912 None 0.992 D 0.664 0.397 0.359151904892 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/D 19915 Fn3-32 39 rs1278035797 0.4991 -1.505 0.999 N 0.666 0.255 0.278143212241 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
E/D 19915 Fn3-32 39 rs1278035797 0.4991 -1.505 0.999 N 0.666 0.255 0.278143212241 gnomAD-3.1.2 5.92E-05 None None None None N None 0 5.89777E-04 0 0 0 None 0 0 0 0 0
E/D 19915 Fn3-32 39 rs1278035797 0.4991 -1.505 0.999 N 0.666 0.255 0.278143212241 gnomAD-4.0.0 1.28258E-05 None None None None N None 0 1.69745E-04 None 0 0 None 0 0 0 0 0
E/Q 19915 Fn3-32 39 rs1310177568 0.3581 None 1.0 N 0.759 0.369 0.267299060538 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/Q 19915 Fn3-32 39 rs1310177568 0.3581 None 1.0 N 0.759 0.369 0.267299060538 gnomAD-4.0.0 6.57938E-06 None None None None N None 2.41429E-05 0 None 0 0 None 0 0 0 0 0
E/D 20015 Fn3-33 39 rs575796706 0.6294 -2.174 0.117 N 0.358 0.066 0.154104182512 gnomAD-2.1.1 2.5E-05 None None None None N None 0 1.70116E-04 None 0 0 None 0 None 0 7.84E-06 0
E/D 20015 Fn3-33 39 rs575796706 0.6294 -2.174 0.117 N 0.358 0.066 0.154104182512 gnomAD-3.1.2 3.95E-05 None None None None N None 0 3.93494E-04 0 0 0 None 0 0 0 0 0
E/D 20015 Fn3-33 39 rs575796706 0.6294 -2.174 0.117 N 0.358 0.066 0.154104182512 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
E/D 20015 Fn3-33 39 rs575796706 0.6294 -2.174 0.117 N 0.358 0.066 0.154104182512 gnomAD-4.0.0 1.9215E-05 None None None None N None 0 2.8356E-04 None 0 0 None 0 0 1.18687E-05 0 0
E/Q 20015 Fn3-33 39 None 0.6731 None 0.997 N 0.805 0.321 0.243972157842 gnomAD-4.0.0 3.18462E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71935E-06 0 0
E/V 20015 Fn3-33 39 rs2050261843 0.9087 None 0.997 N 0.789 0.548 0.677432480161 gnomAD-4.0.0 2.05317E-06 None None None None N None 8.96807E-05 0 None 0 0 None 0 0 0 0 0
E/K 20409 Fn3-36 39 rs2049975714 0.9619 None 0.619 N 0.423 0.405 0.316494231283 gnomAD-4.0.0 2.05339E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69917E-06 0 0
E/D 20607 Fn3-37 39 None 0.9436 None 0.999 N 0.653 0.308 0.269558022972 gnomAD-4.0.0 2.0532E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.47866E-05 0
E/K 20607 Fn3-37 39 None 0.9791 None 0.999 N 0.684 0.436 0.341460817117 gnomAD-4.0.0 1.59233E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85969E-06 0 0
E/Q 20607 Fn3-37 39 rs1396768636 0.7089 None 1.0 N 0.752 0.416 0.276065633971 gnomAD-4.0.0 1.59233E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85969E-06 0 0
E/K 20706 Fn3-38 39 rs773156172 0.9735 -2.529 0.999 N 0.685 0.363 0.402614778071 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
E/K 20706 Fn3-38 39 rs773156172 0.9735 -2.529 0.999 N 0.685 0.363 0.402614778071 gnomAD-4.0.0 1.59244E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8603E-06 0 0
E/D 21102 Fn3-41 39 rs1201894498 0.6445 -1.923 0.104 N 0.31 0.131 0.190952846119 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/D 21102 Fn3-41 39 rs1201894498 0.6445 -1.923 0.104 N 0.31 0.131 0.190952846119 gnomAD-4.0.0 1.59315E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43361E-05 0
E/K 21102 Fn3-41 39 rs1343764526 0.8796 None 0.994 N 0.676 0.425 0.346768085243 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/K 21102 Fn3-41 39 rs1343764526 0.8796 None 0.994 N 0.676 0.425 0.346768085243 gnomAD-4.0.0 3.10022E-06 None None None None N None 1.33583E-05 0 None 0 0 None 0 0 3.39177E-06 0 0
S/R 21404 Fn3-43 39 rs1159259078 0.9262 -0.37 0.976 N 0.747 0.271 0.245101548738 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.65673E-04
S/R 21404 Fn3-43 39 rs1159259078 0.9262 -0.37 0.976 N 0.747 0.271 0.245101548738 gnomAD-4.0.0 1.59262E-06 None None None None N None 0 2.2876E-05 None 0 0 None 0 0 0 0 0
S/T 21404 Fn3-43 39 None 0.1584 None 0.959 N 0.646 0.15 0.278143212241 gnomAD-4.0.0 1.59264E-06 None None None None N None 0 0 None 0 2.77886E-05 None 0 0 0 0 0
E/G 21598 Fn3-44 40 rs1310732379 0.9492 -2.663 0.025 D 0.523 0.383 0.380223377699 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 4.64E-05 0 0
E/G 21598 Fn3-44 40 rs1310732379 0.9492 -2.663 0.025 D 0.523 0.383 0.380223377699 gnomAD-4.0.0 1.59205E-06 None None None None N None 0 0 None 0 0 None 1.8826E-05 0 0 0 0
E/K 21598 Fn3-44 40 None 0.943 None 0.892 D 0.684 0.411 0.411531665326 gnomAD-4.0.0 1.59205E-06 None None None None N None 0 0 None 0 2.77562E-05 None 0 0 0 0 0
E/G 21697 Fn3-45 39 rs1469687198 0.9401 None 1.0 D 0.757 0.531 0.52971305234 gnomAD-4.0.0 1.59232E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43299E-05 0
E/K 21697 Fn3-45 39 None 0.9501 None 0.999 N 0.684 0.505 0.462374447365 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/E 21994 Fn3-47 39 None 0.5551 None 0.011 N 0.345 0.094 0.141422826196 gnomAD-4.0.0 1.20036E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31255E-06 0 0
E/D 22093 Fn3-48 39 None 0.6643 None 0.999 N 0.631 0.224 0.367612772649 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/V 22093 Fn3-48 39 None 0.952 None 1.0 D 0.755 0.55 0.586996327016 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
E/K 22194 Fn3-49 39 rs768049902 0.9587 -1.538 0.999 D 0.685 0.512 0.442363741745 gnomAD-2.1.1 8.91E-05 None None None None N None 0 0 None 0 0 None 7.22591E-04 None 0 0 0
E/K 22194 Fn3-49 39 rs768049902 0.9587 -1.538 0.999 D 0.685 0.512 0.442363741745 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 0 6.21633E-04 0
E/K 22194 Fn3-49 39 rs768049902 0.9587 -1.538 0.999 D 0.685 0.512 0.442363741745 gnomAD-4.0.0 3.5974E-05 None None None None N None 0 0 None 0 0 None 0 0 0 6.15655E-04 3.20574E-05
E/V 22194 Fn3-49 39 rs1425317708 0.9315 -0.726 1.0 D 0.757 0.525 0.629257994256 gnomAD-2.1.1 4.05E-06 None None None None N None 6.5E-05 0 None 0 0 None 0 None 0 0 0
E/V 22194 Fn3-49 39 rs1425317708 0.9315 -0.726 1.0 D 0.757 0.525 0.629257994256 gnomAD-4.0.0 3.18897E-06 None None None None N None 1.13443E-04 0 None 0 0 None 0 0 0 0 0
Q/R 22392 Fn3-50 39 rs753314830 0.8088 -0.777 None N 0.253 0.166 0.181679512989 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.11582E-04 None 3.27E-05 None 0 0 0
Q/R 22392 Fn3-50 39 rs753314830 0.8088 -0.777 None N 0.253 0.166 0.181679512989 gnomAD-4.0.0 6.84371E-06 None None None None N None 0 0 None 0 2.52131E-05 None 0 1.73671E-04 8.99669E-07 8.11651E-05 0
D/H 22489 Fn3-51 39 None 0.5968 None 0.998 N 0.753 0.426 0.359963025489 gnomAD-4.0.0 1.59238E-06 None None None None N None 0 0 None 0 0 None 1.88288E-05 0 0 0 0
E/K 22781 Fn3-53 39 rs760286642 0.9732 -1.796 1.0 N 0.681 0.52 0.379707525713 gnomAD-2.1.1 3.24E-05 None None None None N None 8.27E-05 0 None 0 0 None 0 None 4.16E-05 4.71E-05 0
E/K 22781 Fn3-53 39 rs760286642 0.9732 -1.796 1.0 N 0.681 0.52 0.379707525713 gnomAD-3.1.2 4.6E-05 None None None None N None 9.66E-05 0 0 0 0 None 0 0 4.41E-05 0 0
E/K 22781 Fn3-53 39 rs760286642 0.9732 -1.796 1.0 N 0.681 0.52 0.379707525713 gnomAD-4.0.0 1.61351E-05 None None None None N None 9.35729E-05 0 None 6.76682E-05 0 None 1.59104E-05 0 8.4802E-06 3.29953E-05 4.80754E-05
E/V 22781 Fn3-53 39 rs775528446 0.8754 -1.002 1.0 D 0.768 0.525 0.551879694509 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
E/K 22879 Fn3-54 39 rs373765319 0.9752 -2.378 0.999 D 0.673 0.481 None gnomAD-2.1.1 8.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
E/K 22879 Fn3-54 39 rs373765319 0.9752 -2.378 0.999 D 0.673 0.481 None gnomAD-4.0.0 6.37042E-06 None None None None N None 0 0 None 0 0 None 0 0 1.14405E-05 0 0
E/G 23078 Fn3-55 39 rs761442590 0.9276 -2.495 1.0 D 0.79 0.585 None gnomAD-2.1.1 8.06E-06 None None None None N None 1.29199E-04 0 None 0 0 None 0 None 0 0 0
E/G 23078 Fn3-55 39 rs761442590 0.9276 -2.495 1.0 D 0.79 0.585 None gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/G 23078 Fn3-55 39 rs761442590 0.9276 -2.495 1.0 D 0.79 0.585 None gnomAD-4.0.0 5.12786E-06 None None None None N None 6.77209E-05 0 None 0 0 None 0 0 0 0 0
E/A 23278 Fn3-57 39 None 0.6256 None 0.999 D 0.697 0.565 0.431602765429 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 23278 Fn3-57 39 None 0.7929 None 0.999 N 0.684 0.327 0.341226946553 gnomAD-4.0.0 1.65683E-06 None None None None N None 0 0 None 0 0 None 0 0 2.94083E-06 0 0
E/Q 23473 Fn3-58 39 None 0.5578 None 1.0 N 0.764 0.316 0.27479166964 gnomAD-4.0.0 1.59176E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85914E-06 0 0
E/K 23570 Fn3-59 39 None 0.6334 None 1.0 N 0.678 0.433 0.347879110917 gnomAD-4.0.0 1.59174E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85935E-06 0 0
E/Q 23962 Fn3-62 39 rs1188261866 0.7339 -1.858 1.0 N 0.74 0.394 0.28058544554 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
E/Q 23962 Fn3-62 39 rs1188261866 0.7339 -1.858 1.0 N 0.74 0.394 0.28058544554 gnomAD-4.0.0 1.59284E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86138E-06 0 0
E/A 24260 Fn3-64 39 rs770306141 0.8748 -1.917 0.999 D 0.7 0.524 0.444505407614 gnomAD-2.1.1 5.34E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.12E-05 0
E/A 24260 Fn3-64 39 rs770306141 0.8748 -1.917 0.999 D 0.7 0.524 0.444505407614 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/A 24260 Fn3-64 39 rs770306141 0.8748 -1.917 0.999 D 0.7 0.524 0.444505407614 gnomAD-4.0.0 6.57514E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4708E-05 0 0
E/K 24361 Fn3-65 39 None 0.7944 None 0.999 N 0.67 0.437 0.485493271093 gnomAD-4.0.0 6.84462E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99645E-07 0 0
E/Q 24361 Fn3-65 39 None 0.3263 None 1.0 N 0.745 0.364 0.392855499163 gnomAD-4.0.0 6.84462E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65733E-05
E/K 24557 Fn3-66 39 rs747530483 0.9874 -1.611 1.0 N 0.67 0.478 0.445107144611 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
E/K 24557 Fn3-66 39 rs747530483 0.9874 -1.611 1.0 N 0.67 0.478 0.445107144611 gnomAD-4.0.0 1.08029E-05 None None None None N None 0 0 None 0 0 None 0 0 1.18125E-05 0 0
E/Q 24654 Fn3-67 39 rs766830917 0.4901 -1.828 1.0 N 0.745 0.436 0.351180957027 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
E/K 24847 Fn3-68 40 None 0.8851 None 0.999 D 0.667 0.48 0.422283790207 gnomAD-4.0.0 1.59262E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85979E-06 0 0
E/K 24946 Fn3-69 39 rs758242306 0.8941 -1.014 0.998 N 0.663 0.394 0.401185642668 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/K 24946 Fn3-69 39 rs758242306 0.8941 -1.014 0.998 N 0.663 0.394 0.401185642668 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
E/K 24946 Fn3-69 39 rs758242306 0.8941 -1.014 0.998 N 0.663 0.394 0.401185642668 gnomAD-4.0.0 6.57817E-06 None None None None N None 0 6.55738E-05 None 0 0 None 0 0 0 0 0
E/D 25044 Fn3-70 39 None 0.9651 None 0.999 N 0.633 0.308 0.350746614512 gnomAD-4.0.0 1.36879E-06 None None None None N None 5.98229E-05 0 None 0 0 None 0 0 0 0 0
E/K 25243 Fn3-71 40 None 0.9116 -2.335 0.999 N 0.71 0.54 0.434272847907 gnomAD-2.1.1 8.09E-06 None None None None N None 0 0 None 0 1.12625E-04 None 0 None 0 0 0
E/K 25243 Fn3-71 40 None 0.9116 -2.335 0.999 N 0.71 0.54 0.434272847907 gnomAD-4.0.0 1.36895E-06 None None None None N None 0 0 None 0 5.05842E-05 None 0 0 0 0 0
E/Q 25243 Fn3-71 40 rs1114167338 0.3747 -2.008 1.0 N 0.77 0.335 0.227934060464 gnomAD-2.1.1 8.09E-06 None None None None N None 0 2.91E-05 None 0 5.63E-05 None 0 None 0 0 0
E/Q 25243 Fn3-71 40 rs1114167338 0.3747 -2.008 1.0 N 0.77 0.335 0.227934060464 gnomAD-4.0.0 6.84475E-07 None None None None N None 0 2.23764E-05 None 0 0 None 0 0 0 0 0
E/Q 25342 Fn3-72 39 rs762672000 0.6209 -1.796 1.0 N 0.739 0.346 0.363158594168 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
E/Q 25342 Fn3-72 39 rs762672000 0.6209 -1.796 1.0 N 0.739 0.346 0.363158594168 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/Q 25342 Fn3-72 39 rs762672000 0.6209 -1.796 1.0 N 0.739 0.346 0.363158594168 gnomAD-4.0.0 3.84524E-06 None None None None N None 0 0 None 0 0 None 0 0 7.18236E-06 0 0
E/G 25443 Fn3-73 39 rs879171592 0.8498 -2.867 1.0 D 0.749 0.468 None gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
E/G 25443 Fn3-73 39 rs879171592 0.8498 -2.867 1.0 D 0.749 0.468 None gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/G 25443 Fn3-73 39 rs879171592 0.8498 -2.867 1.0 D 0.749 0.468 None gnomAD-4.0.0 1.31525E-05 None None None None N None 4.82625E-05 0 None 0 0 None 0 0 0 0 0
E/Q 25443 Fn3-73 39 rs1707474479 0.4212 None 1.0 N 0.765 0.35 0.290222751274 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/Q 25443 Fn3-73 39 rs1707474479 0.4212 None 1.0 N 0.765 0.35 0.290222751274 gnomAD-4.0.0 6.57825E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47106E-05 0 0
E/Q 25639 Fn3-74 39 None 0.5236 None 1.0 D 0.749 0.371 0.242244723065 gnomAD-4.0.0 1.61054E-06 None None None None N None 0 2.32786E-05 None 0 0 None 0 0 0 0 0
E/K 25736 Fn3-75 39 None 0.9243 None 0.354 N 0.395 0.386 0.317378411342 gnomAD-4.0.0 1.59209E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8594E-06 0 0
E/Q 25736 Fn3-75 39 None 0.4909 None 0.992 N 0.723 0.298 0.31411915649 gnomAD-4.0.0 1.59209E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43332E-05 0
Q/E 25929 Fn3-76 40 rs758386212 0.1059 -2.121 None N 0.3 0.152 0.0954503805726 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
Q/E 25929 Fn3-76 40 rs758386212 0.1059 -2.121 None N 0.3 0.152 0.0954503805726 gnomAD-4.0.0 2.05317E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31889E-05 1.6575E-05
Q/H 25929 Fn3-76 40 rs1435821903 0.2661 -1.746 0.001 N 0.334 0.168 0.0954503805726 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
Q/H 25929 Fn3-76 40 rs1435821903 0.2661 -1.746 0.001 N 0.334 0.168 0.0954503805726 gnomAD-4.0.0 1.5922E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85956E-06 0 0
Q/R 25929 Fn3-76 40 rs750283007 0.2235 -0.903 0.351 N 0.613 0.185 0.126345400529 gnomAD-2.1.1 7.15E-06 None None None None N None 0 0 None 0 1.03189E-04 None 0 None 0 0 0
Q/R 25929 Fn3-76 40 rs750283007 0.2235 -0.903 0.351 N 0.613 0.185 0.126345400529 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.93199E-04 None 0 0 0 0 0
Q/R 25929 Fn3-76 40 rs750283007 0.2235 -0.903 0.351 N 0.613 0.185 0.126345400529 gnomAD-4.0.0 2.56345E-06 None None None None N None 0 0 None 0 4.86216E-05 None 0 0 0 0 0
E/Q 26126 Fn3-78 39 rs1325081624 0.839 -1.65 1.0 N 0.747 0.363 0.277730125212 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/Q 26126 Fn3-78 39 rs1325081624 0.839 -1.65 1.0 N 0.747 0.363 0.277730125212 gnomAD-4.0.0 1.59236E-06 None None None None N None 0 2.2877E-05 None 0 0 None 0 0 0 0 0
E/A 26424 Fn3-80 39 None 0.9521 None 0.999 D 0.697 0.603 0.441324992753 gnomAD-4.0.0 1.59206E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
E/K 26424 Fn3-80 39 rs1706064410 0.97 None 0.999 N 0.67 0.492 0.342400092842 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 26424 Fn3-80 39 rs1706064410 0.97 None 0.999 N 0.67 0.492 0.342400092842 gnomAD-4.0.0 6.57471E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4705E-05 0 0
E/G 26525 Fn3-81 39 rs760756282 0.6777 -2.421 1.0 D 0.782 0.589 0.477298106951 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/G 26525 Fn3-81 39 rs760756282 0.6777 -2.421 1.0 D 0.782 0.589 0.477298106951 gnomAD-4.0.0 2.73782E-06 None None None None N None 0 2.23624E-05 None 0 0 None 0 0 2.69853E-06 0 0
D/E 26721 Fn3-82 39 None 0.4206 None 0.067 N 0.366 0.092 0.0762999501168 gnomAD-4.0.0 6.84275E-07 None None None None N None 0 0 None 0 0 None 1.87266E-05 0 0 0 0
E/D 26818 Fn3-83 39 rs771164870 0.7228 -1.881 0.998 N 0.676 0.41 0.373357554552 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/D 26818 Fn3-83 39 rs771164870 0.7228 -1.881 0.998 N 0.676 0.41 0.373357554552 gnomAD-4.0.0 1.59158E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
E/D 27011 Fn3-84 40 rs765653425 0.6927 -1.868 0.996 N 0.638 0.329 0.28492961333 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
E/D 27011 Fn3-84 40 rs765653425 0.6927 -1.868 0.996 N 0.638 0.329 0.28492961333 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 3.16456E-03 1.47E-05 0 0
E/D 27011 Fn3-84 40 rs765653425 0.6927 -1.868 0.996 N 0.638 0.329 0.28492961333 gnomAD-4.0.0 6.84294E-07 None None None None N None 2.98918E-05 0 None 0 0 None 0 0 0 0 0
E/D 27208 Fn3-86 39 None 0.9802 None 0.999 N 0.657 0.349 0.353548585375 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
E/K 27208 Fn3-86 39 None 0.9763 None 0.999 D 0.68 0.446 0.461845970543 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
E/G 27408 Fn3-87 40 None 0.8298 None 1.0 D 0.741 0.522 0.499473279415 gnomAD-4.0.0 1.59138E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85866E-06 0 0
E/D 27507 Fn3-88 39 None 0.8096 None 0.958 N 0.614 0.212 0.279370189704 gnomAD-4.0.0 1.36841E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79896E-06 0 0
E/D 27608 Fn3-89 39 None 0.7 None 0.999 N 0.653 0.345 0.30921473904 gnomAD-4.0.0 1.59162E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85881E-06 0 0
E/Q 27608 Fn3-89 39 None 0.2943 None 1.0 N 0.743 0.342 0.27479166964 gnomAD-4.0.0 3.18322E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71755E-06 0 0
E/K 27804 Fn3-90 39 rs759095633 0.9689 -1.614 1.0 N 0.685 0.457 0.444706120422 gnomAD-2.1.1 2.51E-05 None None None None N None 1.31148E-04 0 None 0 5.75E-05 None 0 None 0 1.82E-05 1.75254E-04
E/K 27804 Fn3-90 39 rs759095633 0.9689 -1.614 1.0 N 0.685 0.457 0.444706120422 gnomAD-4.0.0 1.24416E-05 None None None None N None 1.23069E-04 0 None 0 2.53254E-05 None 1.88708E-05 0 1.08546E-05 0 0
E/G 27901 Fn3-91 39 rs1213668356 0.7918 None 1.0 D 0.745 0.604 0.61617715924 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/G 27901 Fn3-91 39 rs1213668356 0.7918 None 1.0 D 0.745 0.604 0.61617715924 gnomAD-4.0.0 6.57194E-06 None None None None N None 2.41301E-05 0 None 0 0 None 0 0 0 0 0
E/Q 27901 Fn3-91 39 rs1048498149 0.3976 None 1.0 N 0.765 0.361 0.361160317528 gnomAD-4.0.0 6.84468E-07 None None None None N None 2.98972E-05 0 None 0 0 None 0 0 0 0 0
E/K 28192 Fn3-93 39 rs879123930 0.9639 None 0.999 N 0.681 0.444 0.37568098594 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 28192 Fn3-93 39 rs879123930 0.9639 None 0.999 N 0.681 0.444 0.37568098594 gnomAD-4.0.0 2.47956E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39105E-06 0 0
E/Q 28290 Fn3-94 39 None 0.6491 None 1.0 N 0.756 0.395 0.276898752692 gnomAD-4.0.0 1.36846E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79891E-06 0 0
E/K 28689 Fn3-97 39 None 0.777 None 0.767 N 0.393 0.358 0.305730143919 gnomAD-4.0.0 4.80131E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25003E-06 0 0
E/Q 29275 Fn3-101 39 rs766410679 0.6123 -1.028 0.31 D 0.373 0.213 0.229264304666 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
E/K 29373 Fn3-102 39 rs762557803 0.9535 -1.189 0.117 D 0.439 0.415 0.251639045875 gnomAD-2.1.1 6.84E-05 None None None None N None 0 3.47947E-04 None 9.95E-05 0 None 0 None 0 8.89E-06 4.97678E-04
E/K 29373 Fn3-102 39 rs762557803 0.9535 -1.189 0.117 D 0.439 0.415 0.251639045875 gnomAD-4.0.0 2.70543E-05 None None None None N None 0 3.20088E-04 None 4.7669E-05 0 None 0 0 0 0 6.04887E-05
E/D 29572 Fn3-103 40 rs982929672 0.8037 None 0.999 N 0.683 0.259 0.268660756437 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/D 29572 Fn3-103 40 rs982929672 0.8037 None 0.999 N 0.683 0.259 0.268660756437 gnomAD-4.0.0 2.56181E-06 None None None None N None 3.38123E-05 0 None 0 0 None 0 0 0 0 0
E/Q 29671 Fn3-104 39 None 0.4403 None 1.0 N 0.77 0.304 0.279370189704 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
E/K 29772 Fn3-105 39 None 0.4954 -1.494 0.271 N 0.649 0.265 None gnomAD-2.1.1 2.394E-04 None None None None N None 4.13223E-04 2.82933E-04 None 9.68E-05 0 None 3.27E-05 None 0 3.36432E-04 2.81294E-04
E/K 29772 Fn3-105 39 None 0.4954 -1.494 0.271 N 0.649 0.265 None gnomAD-3.1.2 2.82631E-04 None None None None N None 4.58494E-04 1.31113E-04 0 0 0 None 0 0 3.08715E-04 2.06954E-04 0
E/K 29772 Fn3-105 39 None 0.4954 -1.494 0.271 N 0.649 0.265 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
E/K 29772 Fn3-105 39 None 0.4954 -1.494 0.271 N 0.649 0.265 None gnomAD-4.0.0 2.80701E-04 None None None None N None 4.26451E-04 2.66684E-04 None 3.37792E-05 0 None 0 1.65017E-04 3.29715E-04 3.29366E-05 1.76068E-04
E/Q 29772 Fn3-105 39 rs200503016 0.1539 None 0.01 N 0.439 0.148 0.178374595973 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/Q 29772 Fn3-105 39 rs200503016 0.1539 None 0.01 N 0.439 0.148 0.178374595973 gnomAD-4.0.0 6.57281E-06 None None None None N None 2.41313E-05 0 None 0 0 None 0 0 0 0 0
E/G 29971 Fn3-106 39 rs1361724655 0.8662 -2.058 0.946 D 0.751 0.476 0.470237251169 gnomAD-4.0.0 1.59536E-06 None None None None N None 0 0 None 0 0 None 0 2.41196E-04 0 0 0
E/A 30068 Fn3-107 39 rs1281127111 0.568 -1.319 0.999 D 0.689 0.503 0.434497104326 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
E/A 30068 Fn3-107 39 rs1281127111 0.568 -1.319 0.999 D 0.689 0.503 0.434497104326 gnomAD-4.0.0 1.59106E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85788E-06 0 0
E/G 30068 Fn3-107 39 rs1281127111 0.7344 -1.967 1.0 D 0.762 0.521 0.478144874143 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/G 30068 Fn3-107 39 rs1281127111 0.7344 -1.967 1.0 D 0.762 0.521 0.478144874143 gnomAD-4.0.0 1.59106E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
E/K 30263 Fn3-108 40 rs745701838 0.9577 -2.175 1.0 N 0.693 0.457 0.423002944196 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 1.78E-05 0
E/K 30263 Fn3-108 40 rs745701838 0.9577 -2.175 1.0 N 0.693 0.457 0.423002944196 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/K 30263 Fn3-108 40 rs745701838 0.9577 -2.175 1.0 N 0.693 0.457 0.423002944196 gnomAD-4.0.0 6.81697E-06 None None None None N None 2.6703E-05 0 None 0 8.91345E-05 None 0 0 4.23811E-06 0 0
E/K 30362 Fn3-109 39 rs764904720 0.9289 -1.461 0.999 N 0.69 0.473 0.524271286562 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
E/K 30362 Fn3-109 39 rs764904720 0.9289 -1.461 0.999 N 0.69 0.473 0.524271286562 gnomAD-4.0.0 2.05257E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69835E-06 0 0
E/Q 30362 Fn3-109 39 rs764904720 0.5863 -1.291 1.0 N 0.755 0.336 0.295623431141 gnomAD-2.1.1 1.43E-05 None None None None N None 0 0 None 0 0 None 0 None 1.19914E-04 7.83E-06 0
E/Q 30362 Fn3-109 39 rs764904720 0.5863 -1.291 1.0 N 0.755 0.336 0.295623431141 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/Q 30362 Fn3-109 39 rs764904720 0.5863 -1.291 1.0 N 0.755 0.336 0.295623431141 gnomAD-4.0.0 1.05349E-05 None None None None N None 0 0 None 0 0 None 2.34368E-04 0 8.47598E-07 0 1.60102E-05
E/K 30460 Fn3-110 39 rs908278682 0.9723 -1.21 0.999 D 0.669 0.461 0.378322506985 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14732E-04 0 None 0 0 None 0 None 0 0 0
E/K 30460 Fn3-110 39 rs908278682 0.9723 -1.21 0.999 D 0.669 0.461 0.378322506985 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/K 30460 Fn3-110 39 rs908278682 0.9723 -1.21 0.999 D 0.669 0.461 0.378322506985 gnomAD-4.0.0 6.57393E-06 None None None None N None 2.41394E-05 0 None 0 0 None 0 0 0 0 0
E/D 30658 Fn3-111 40 rs1240970665 0.8222 -1.609 0.999 N 0.645 0.353 0.231231049324 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/D 30658 Fn3-111 40 rs1240970665 0.8222 -1.609 0.999 N 0.645 0.353 0.231231049324 gnomAD-4.0.0 1.59142E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43291E-05 0
E/Q 30757 Fn3-112 39 None 0.2446 None 1.0 N 0.732 0.398 0.359357374593 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 31054 Fn3-114 39 rs1049541565 0.7582 None 0.896 N 0.629 0.37 0.32053947749 gnomAD-4.0.0 1.59107E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
E/Q 31347 Fn3-116 40 rs886055230 0.4955 None 1.0 N 0.779 0.287 0.270001397563 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.93125E-04 None 0 0 0 0 0
E/Q 31347 Fn3-116 40 rs886055230 0.4955 None 1.0 N 0.779 0.287 0.270001397563 gnomAD-4.0.0 1.79338E-05 None None None None N None 0 0 None 0 3.39526E-04 None 0 0 0 0 0
E/A 31446 Fn3-117 39 None 0.9744 None 0.999 D 0.701 0.551 0.481915485015 gnomAD-4.0.0 1.5912E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85827E-06 0 0
E/Q 31544 Fn3-118 39 rs1024530763 0.8128 -2.119 1.0 N 0.789 0.415 0.33440975612 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/Q 31544 Fn3-118 39 rs1024530763 0.8128 -2.119 1.0 N 0.789 0.415 0.33440975612 gnomAD-4.0.0 1.59165E-06 None None None None N None 0 2.28686E-05 None 0 0 None 0 0 0 0 0
E/G 31746 Fn3-119 39 None 0.9306 None 1.0 D 0.799 0.584 0.500050830518 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
D/N 31845 Fn3-120 39 rs772648821 0.6146 -2.372 0.999 N 0.781 0.325 0.442261297928 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.56E-05 None 0 None 0 0 0
E/G 31947 Fn3-121 39 None 0.8668 None 1.0 D 0.763 0.525 0.522290170867 gnomAD-4.0.0 1.59136E-06 None None None None N None 0 0 None 0 2.77346E-05 None 0 0 0 0 0
E/G 32143 Fn3-122 39 rs904892183 0.9566 -2.026 1.0 N 0.745 0.605 0.469989170139 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
E/G 32143 Fn3-122 39 rs904892183 0.9566 -2.026 1.0 N 0.745 0.605 0.469989170139 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/G 32143 Fn3-122 39 rs904892183 0.9566 -2.026 1.0 N 0.745 0.605 0.469989170139 gnomAD-4.0.0 1.41169E-05 None None None None N None 0 0 None 0 0 None 0 0 2.39329E-05 0 2.84641E-05
E/K 32143 Fn3-122 39 rs1002264891 0.972 None 1.0 N 0.694 0.387 0.352910780287 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 32143 Fn3-122 39 rs1002264891 0.972 None 1.0 N 0.694 0.387 0.352910780287 gnomAD-4.0.0 1.86078E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54295E-06 0 0
E/K 32240 Fn3-123 39 rs374598326 0.9409 -2.477 1.0 N 0.68 0.389 None gnomAD-2.1.1 2.01E-05 None None None None N None 6.46E-05 0 None 9.94E-05 0 None 0 None 0 2.66E-05 0
E/K 32240 Fn3-123 39 rs374598326 0.9409 -2.477 1.0 N 0.68 0.389 None gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/K 32240 Fn3-123 39 rs374598326 0.9409 -2.477 1.0 N 0.68 0.389 None gnomAD-4.0.0 1.61129E-05 None None None None N None 4.00759E-05 1.66761E-05 None 3.37838E-05 0 None 0 0 1.69522E-05 0 1.60108E-05
E/Q 32240 Fn3-123 39 rs374598326 0.7008 -2.128 1.0 N 0.76 0.314 0.300449992093 gnomAD-2.1.1 3.2E-05 None None None None N None 1.14943E-04 0 None 0 0 None 0 None 0 0 0
E/Q 32240 Fn3-123 39 rs374598326 0.7008 -2.128 1.0 N 0.76 0.314 0.300449992093 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
E/Q 32240 Fn3-123 39 rs374598326 0.7008 -2.128 1.0 N 0.76 0.314 0.300449992093 gnomAD-4.0.0 6.57782E-06 None None None None N None 2.41604E-05 0 None 0 0 None 0 0 0 0 0
E/Q 32438 Fn3-124 40 None 0.6361 None 1.0 N 0.73 0.32 0.303453137403 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 32537 Fn3-125 39 rs1192763784 0.9034 None 0.999 N 0.692 0.559 0.432826170204 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 32537 Fn3-125 39 rs1192763784 0.9034 None 0.999 N 0.692 0.559 0.432826170204 gnomAD-4.0.0 6.57376E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47029E-05 0 0
E/A 32834 Fn3-127 40 rs2154140011 0.9115 None 0.999 D 0.685 0.556 0.451692371253 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 9.49367E-03 0 0 0
E/A 32834 Fn3-127 40 rs2154140011 0.9115 None 0.999 D 0.685 0.556 0.451692371253 gnomAD-4.0.0 6.40431E-06 None None None None N None 0 0 None 0 0 None 0 6.7598E-04 0 0 5.6844E-05
E/K 32834 Fn3-127 40 rs199761901 0.9415 -1.651 1.0 N 0.685 0.42 None gnomAD-2.1.1 1.57071E-04 None None None None N None 1.48834E-03 2.83E-05 None 0 0 None 0 None 0 5.47E-05 0
E/K 32834 Fn3-127 40 rs199761901 0.9415 -1.651 1.0 N 0.685 0.42 None gnomAD-3.1.2 3.48441E-04 None None None None N None 1.23176E-03 0 0 0 0 None 0 0 1.47E-05 0 4.78469E-04
E/K 32834 Fn3-127 40 rs199761901 0.9415 -1.651 1.0 N 0.685 0.42 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
E/K 32834 Fn3-127 40 rs199761901 0.9415 -1.651 1.0 N 0.685 0.42 None gnomAD-4.0.0 9.41866E-05 None None None None N None 1.49349E-03 1.66639E-05 None 0 4.45792E-05 None 0 0 2.62758E-05 0 9.60307E-05
E/Q 32834 Fn3-127 40 rs199761901 0.4316 -1.479 1.0 N 0.757 0.314 0.301789629655 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/Q 32834 Fn3-127 40 rs199761901 0.4316 -1.479 1.0 N 0.757 0.314 0.301789629655 gnomAD-4.0.0 6.84185E-07 None None None None N None 0 2.23614E-05 None 0 0 None 0 0 0 0 0
E/G 32935 Fn3-128 40 rs879037584 0.9637 None 0.993 D 0.758 0.52 None gnomAD-4.0.0 3.18265E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71713E-06 0 0
E/K 32935 Fn3-128 40 rs1407053984 0.9663 -1.495 0.996 N 0.653 0.441 0.456368778954 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
E/K 32935 Fn3-128 40 rs1407053984 0.9663 -1.495 0.996 N 0.653 0.441 0.456368778954 gnomAD-3.1.2 1.97E-05 None None None None N None 4.83E-05 6.55E-05 0 0 0 None 0 0 0 0 0
E/K 32935 Fn3-128 40 rs1407053984 0.9663 -1.495 0.996 N 0.653 0.441 0.456368778954 gnomAD-4.0.0 1.11555E-05 None None None None N None 2.67144E-05 3.33456E-05 None 0 0 None 0 0 1.01717E-05 2.19568E-05 0
E/K 33036 Fn3-129 39 None 0.968 None 0.999 N 0.708 0.435 0.461323234107 gnomAD-4.0.0 1.59136E-06 None None None None N None 0 0 None 0 2.773E-05 None 0 0 0 0 0
E/G 33430 Fn3-131 39 rs1451693700 0.8746 -1.971 1.0 D 0.79 0.515 0.547512163748 gnomAD-2.1.1 3.18E-05 None None None None N None 1.14705E-04 0 None 0 0 None 0 None 0 0 0
E/G 33430 Fn3-131 39 rs1451693700 0.8746 -1.971 1.0 D 0.79 0.515 0.547512163748 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/G 33430 Fn3-131 39 rs1451693700 0.8746 -1.971 1.0 D 0.79 0.515 0.547512163748 gnomAD-4.0.0 6.56866E-06 None None None None N None 2.41161E-05 0 None 0 0 None 0 0 0 0 0
E/K 33430 Fn3-131 39 None 0.8934 None 0.999 N 0.679 0.476 0.417334834585 gnomAD-4.0.0 6.87785E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.17603E-05 0
E/Q 33430 Fn3-131 39 rs1306593983 0.3571 -1.101 1.0 N 0.762 0.301 0.233150807113 gnomAD-2.1.1 8.23E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.81E-05 0
E/Q 33430 Fn3-131 39 rs1306593983 0.3571 -1.101 1.0 N 0.762 0.301 0.233150807113 gnomAD-4.0.0 6.87785E-06 None None None None N None 0 0 None 0 0 None 0 0 9.02829E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.