Structural position:

  • Domain Type: Fn3
  • Aligned Position: 43
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand C

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
R/C 15697 Fn3-1 41 rs780334981 0.59 -1.669 1.0 D 0.909 0.459 0.528959857459 gnomAD-2.1.1 3.58E-05 None None None None N None 8.28E-05 0 None 0 5.19E-05 None 9.81E-05 None 0 3.14E-05 0
R/C 15697 Fn3-1 41 rs780334981 0.59 -1.669 1.0 D 0.909 0.459 0.528959857459 gnomAD-3.1.2 3.29E-05 None None None None N None 4.83E-05 6.57E-05 0 0 0 None 0 0 2.95E-05 0 0
R/C 15697 Fn3-1 41 rs780334981 0.59 -1.669 1.0 D 0.909 0.459 0.528959857459 gnomAD-4.0.0 5.58195E-05 None None None None N None 4.01059E-05 6.68315E-05 None 0 2.24085E-05 None 0 0 6.44557E-05 5.49137E-05 1.60303E-05
R/G 15697 Fn3-1 41 None 0.9745 None 1.0 D 0.777 0.477 0.560529172091 gnomAD-4.0.0 6.84691E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99915E-07 0 0
R/H 15697 Fn3-1 41 rs757663389 0.6985 -2.32 1.0 D 0.764 0.581 0.460703734027 gnomAD-2.1.1 3.58E-05 None None None None N None 8.28E-05 0 None 0 2.59363E-04 None 0 None 0 2.35E-05 0
R/H 15697 Fn3-1 41 rs757663389 0.6985 -2.32 1.0 D 0.764 0.581 0.460703734027 gnomAD-3.1.2 2.63E-05 None None None None N None 7.24E-05 0 0 0 1.95084E-04 None 0 0 0 0 0
R/H 15697 Fn3-1 41 rs757663389 0.6985 -2.32 1.0 D 0.764 0.581 0.460703734027 gnomAD-4.0.0 2.17067E-05 None None None None N None 6.68253E-05 0 None 0 3.58343E-04 None 0 0 1.01774E-05 2.19616E-05 0
C/R 15899 Fn3-3 41 rs1232133882 0.1223 -1.364 None N 0.441 0.133 0.404453528171 gnomAD-2.1.1 9.16E-06 None None None None N None 0 0 None 0 1.24704E-04 None 0 None 0 0 0
C/R 15899 Fn3-3 41 rs1232133882 0.1223 -1.364 None N 0.441 0.133 0.404453528171 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
C/R 15899 Fn3-3 41 rs1232133882 0.1223 -1.364 None N 0.441 0.133 0.404453528171 gnomAD-4.0.0 3.1449E-06 None None None None N None 0 0 None 0 6.78273E-05 None 0 0 1.70807E-06 0 0
R/Q 16095 Fn3-4 41 rs369453963 0.47 -1.039 0.999 N 0.511 0.324 None gnomAD-2.1.1 2.87E-05 None None None None N None 8.29E-05 0 None 0 0 None 0 None 1.9984E-04 7.86E-06 0
R/Q 16095 Fn3-4 41 rs369453963 0.47 -1.039 0.999 N 0.511 0.324 None gnomAD-3.1.2 1.98E-05 None None None None N None 0 0 0 0 0 None 1.88644E-04 0 1.47E-05 0 0
R/Q 16095 Fn3-4 41 rs369453963 0.47 -1.039 0.999 N 0.511 0.324 None gnomAD-4.0.0 8.68408E-06 None None None None N None 2.67465E-05 0 None 0 0 None 7.81348E-05 0 5.93796E-06 0 0
C/R 16195 Fn3-5 41 None 0.5639 None 0.968 N 0.791 0.478 0.726404257552 gnomAD-4.0.0 6.00161E-06 None None None None N None 0 0 None 0 0 None 0 0 6.56251E-06 0 0
C/Y 16195 Fn3-5 41 None 0.5358 None 0.995 D 0.732 0.277 0.679388506755 gnomAD-4.0.0 1.36944E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79998E-06 0 0
R/Q 16391 Fn3-6 41 rs200944827 0.1768 -1.214 0.271 D 0.478 0.191 None gnomAD-2.1.1 1.29208E-04 None None None None N None 4.14E-05 2.55638E-04 None 0 4.17493E-04 None 0 None 0 1.2584E-04 2.82008E-04
R/Q 16391 Fn3-6 41 rs200944827 0.1768 -1.214 0.271 D 0.478 0.191 None gnomAD-3.1.2 1.31737E-04 None None None None N None 9.67E-05 4.60163E-04 0 0 3.90625E-04 None 0 0 1.03093E-04 0 0
R/Q 16391 Fn3-6 41 rs200944827 0.1768 -1.214 0.271 D 0.478 0.191 None gnomAD-4.0.0 1.60631E-04 None None None None N None 5.34845E-05 2.8411E-04 None 0 1.79582E-04 None 0 0 1.84861E-04 4.39338E-05 1.28254E-04
L/R 16591 Fn3-8 41 None 0.1619 None 0.999 N 0.87 0.312 0.719045985532 gnomAD-4.0.0 1.59354E-06 None None None None N None 0 0 None 0 2.78956E-05 None 0 0 0 0 0
C/F 16892 Fn3-11 41 rs958402858 0.7824 None 1.0 N 0.875 0.415 0.785167026474 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
C/F 16892 Fn3-11 41 rs958402858 0.7824 None 1.0 N 0.875 0.415 0.785167026474 gnomAD-4.0.0 6.57895E-06 None None None None N None 2.41336E-05 0 None 0 0 None 0 0 0 0 0
C/R 16892 Fn3-11 41 rs1256128085 0.7465 -1.498 1.0 N 0.886 0.537 0.77036421607 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
C/R 16892 Fn3-11 41 rs1256128085 0.7465 -1.498 1.0 N 0.886 0.537 0.77036421607 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
C/R 16892 Fn3-11 41 rs1256128085 0.7465 -1.498 1.0 N 0.886 0.537 0.77036421607 gnomAD-4.0.0 2.16996E-05 None None None None N None 0 0 None 0 0 None 0 0 2.9678E-05 0 0
R/G 17087 Fn3-12 41 rs1483164102 0.9907 -2.558 1.0 N 0.767 0.537 0.506912157699 gnomAD-2.1.1 8.05E-06 None None None None N None 6.46E-05 2.9E-05 None 0 0 None 0 None 0 0 0
R/G 17087 Fn3-12 41 rs1483164102 0.9907 -2.558 1.0 N 0.767 0.537 0.506912157699 gnomAD-4.0.0 2.73803E-06 None None None None N None 8.97827E-05 2.23674E-05 None 0 0 None 0 0 0 0 0
R/T 17087 Fn3-12 41 None 0.9958 None 1.0 N 0.75 0.481 0.451504584351 gnomAD-4.0.0 1.59284E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86172E-06 0 0
I/M 17187 Fn3-13 41 None 0.0884 None 0.009 N 0.175 0.025 0.315609569513 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
I/T 17187 Fn3-13 41 None 0.2604 None 0.183 N 0.529 0.17 0.54848712621 gnomAD-4.0.0 1.36893E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99794E-07 1.15972E-05 0
K/E 17409 Fn3-14 41 rs1203045644 0.5822 -1.986 0.999 N 0.534 0.462 0.392855499163 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
K/E 17409 Fn3-14 41 rs1203045644 0.5822 -1.986 0.999 N 0.534 0.462 0.392855499163 gnomAD-4.0.0 3.18747E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72377E-06 0 0
R/C 17509 Fn3-15 40 rs748170111 0.7876 -1.641 1.0 N 0.891 0.481 0.365892764245 gnomAD-2.1.1 8.14E-06 None None None None N None 0 0 None 0 0 None 3.29E-05 None 0 9E-06 0
R/C 17509 Fn3-15 40 rs748170111 0.7876 -1.641 1.0 N 0.891 0.481 0.365892764245 gnomAD-3.1.2 1.98E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 2.07211E-04 0
R/C 17509 Fn3-15 40 rs748170111 0.7876 -1.641 1.0 N 0.891 0.481 0.365892764245 gnomAD-4.0.0 4.96392E-06 None None None None N None 0 0 None 0 0 None 0 0 4.24093E-06 3.30033E-05 0
R/H 17509 Fn3-15 40 rs886055267 0.6654 -2.543 1.0 N 0.771 0.484 0.423119698836 gnomAD-2.1.1 3.24E-05 None None None None N None 4.16E-05 0 None 0 1.04679E-04 None 3.29E-05 None 0 3.95E-05 0
R/H 17509 Fn3-15 40 rs886055267 0.6654 -2.543 1.0 N 0.771 0.484 0.423119698836 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/H 17509 Fn3-15 40 rs886055267 0.6654 -2.543 1.0 N 0.771 0.484 0.423119698836 gnomAD-4.0.0 3.16389E-05 None None None None N None 1.33647E-05 1.67096E-05 None 0 2.24527E-05 None 0 0 3.90133E-05 1.09987E-05 1.6039E-05
Q/E 17609 Fn3-16 41 rs777990934 0.2635 -2.417 0.625 N 0.517 0.17 0.159798565429 gnomAD-2.1.1 8.05E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
Q/E 17609 Fn3-16 41 rs777990934 0.2635 -2.417 0.625 N 0.517 0.17 0.159798565429 gnomAD-4.0.0 3.18572E-06 None None None None N None 0 4.57561E-05 None 0 0 None 0 0 0 0 0
Q/K 17609 Fn3-16 41 None 0.2105 None 0.625 N 0.582 0.216 0.115124310173 gnomAD-4.0.0 1.59286E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8613E-06 0 0
Q/L 17609 Fn3-16 41 rs368820294 0.3039 -1.206 0.891 N 0.625 0.232 None gnomAD-2.1.1 1.00062E-04 None None None None N None 8.27E-05 2.83E-05 None 0 0 None 0 None 0 1.95502E-04 0
Q/L 17609 Fn3-16 41 rs368820294 0.3039 -1.206 0.891 N 0.625 0.232 None gnomAD-3.1.2 1.77681E-04 None None None None N None 4.83E-05 6.56E-05 0 0 0 None 0 0 3.38634E-04 0 4.77555E-04
Q/L 17609 Fn3-16 41 rs368820294 0.3039 -1.206 0.891 N 0.625 0.232 None gnomAD-4.0.0 2.15749E-04 None None None None N None 2.66773E-05 5.00384E-05 None 0 0 None 0 0 2.89155E-04 0 3.20328E-05
R/Q 17902 Fn3-18 41 rs781600329 0.2152 -1.024 0.873 N 0.481 0.311 0.177238962908 gnomAD-2.1.1 3.22E-05 None None None None N None 0 0 None 9.97E-05 0 None 1.63473E-04 None 0 1.78E-05 0
R/Q 17902 Fn3-18 41 rs781600329 0.2152 -1.024 0.873 N 0.481 0.311 0.177238962908 gnomAD-4.0.0 8.21778E-06 None None None None N None 0 0 None 3.83406E-05 0 None 0 0 5.40107E-06 5.80437E-05 0
R/W 17902 Fn3-18 41 rs748647255 0.6503 -0.739 0.998 N 0.629 0.412 0.340992353424 gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 5.16E-05 None 0 None 0 1.57E-05 0
R/W 17902 Fn3-18 41 rs748647255 0.6503 -0.739 0.998 N 0.629 0.412 0.340992353424 gnomAD-3.1.2 6.6E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/W 17902 Fn3-18 41 rs748647255 0.6503 -0.739 0.998 N 0.629 0.412 0.340992353424 gnomAD-4.0.0 3.72431E-06 None None None None N None 0 0 None 0 4.47928E-05 None 0 0 3.3945E-06 0 0
R/C 18105 Fn3-19 41 rs765739434 0.3452 -1.81 1.0 N 0.802 0.415 None gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.35E-05 0
R/C 18105 Fn3-19 41 rs765739434 0.3452 -1.81 1.0 N 0.802 0.415 None gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 18105 Fn3-19 41 rs765739434 0.3452 -1.81 1.0 N 0.802 0.415 None gnomAD-4.0.0 2.0472E-05 None None None None N None 0 0 None 0 0 None 0 0 2.3751E-05 4.39986E-05 1.60298E-05
R/G 18105 Fn3-19 41 None 0.8682 None 0.996 N 0.741 0.418 0.580927594641 gnomAD-4.0.0 6.84844E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00105E-07 0 0
R/H 18105 Fn3-19 41 rs760383112 0.3318 -2.794 1.0 N 0.679 0.41 0.279370189704 gnomAD-2.1.1 3.94E-05 None None None None N None 0 1.70232E-04 None 0 0 None 9.83E-05 None 0 1.56E-05 0
R/H 18105 Fn3-19 41 rs760383112 0.3318 -2.794 1.0 N 0.679 0.41 0.279370189704 gnomAD-3.1.2 1.98E-05 None None None None N None 2.42E-05 6.56E-05 0 0 0 None 0 0 1.47E-05 0 0
R/H 18105 Fn3-19 41 rs760383112 0.3318 -2.794 1.0 N 0.679 0.41 0.279370189704 gnomAD-4.0.0 1.67479E-05 None None None None N None 1.33693E-05 1.50306E-04 None 0 0 None 1.56367E-05 0 8.48211E-06 3.29939E-05 4.80893E-05
R/T 18206 Fn3-20 41 None 0.8367 None 0.003 N 0.309 0.371 0.312001716656 gnomAD-4.0.0 1.59315E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02792E-05
Q/R 18312 Fn3-21 41 rs754977491 0.2417 -1.107 0.997 N 0.502 0.415 0.231231049324 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
Q/R 18312 Fn3-21 41 rs754977491 0.2417 -1.107 0.997 N 0.502 0.415 0.231231049324 gnomAD-4.0.0 1.59458E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86325E-06 0 0
R/K 18519 Fn3-22 41 None 0.0918 None None N 0.148 0.168 0.107399877778 gnomAD-4.0.0 1.36906E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79955E-06 0 0
R/T 18519 Fn3-22 41 None 0.8739 None 0.117 N 0.454 0.13 0.200317383148 gnomAD-4.0.0 6.84529E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99776E-07 0 0
L/P 18619 Fn3-23 41 rs1375513422 0.9831 None 1.0 N 0.851 0.628 0.830745573214 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/P 18619 Fn3-23 41 rs1375513422 0.9831 None 1.0 N 0.851 0.628 0.830745573214 gnomAD-4.0.0 6.58077E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47119E-05 0 0
R/K 18825 Fn3-24 42 None 0.2346 None 0.008 N 0.183 0.143 0.226586394389 gnomAD-4.0.0 6.85839E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00513E-07 0 0
R/T 18825 Fn3-24 42 None 0.9008 None 0.722 N 0.584 0.387 0.337868961071 gnomAD-4.0.0 2.05752E-06 None None None None N None 0 0 None 0 2.53229E-05 None 0 0 1.80103E-06 0 0
K/T 19028 Fn3-26 41 rs765612779 0.4191 -1.94 0.999 N 0.73 0.476 0.359763055319 gnomAD-2.1.1 8.18E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
K/T 19028 Fn3-26 41 rs765612779 0.4191 -1.94 0.999 N 0.73 0.476 0.359763055319 gnomAD-4.0.0 3.20645E-06 None None None None N None 0 0 None 0 0 None 0 0 5.73414E-06 0 0
R/C 19224 Fn3-27 42 rs746014932 0.6981 -1.892 1.0 N 0.907 0.462 0.604474940213 gnomAD-2.1.1 4.17E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.23E-06 0
R/C 19224 Fn3-27 42 rs746014932 0.6981 -1.892 1.0 N 0.907 0.462 0.604474940213 gnomAD-3.1.2 2.63E-05 None None None None N None 2.42E-05 1.31148E-04 0 0 0 None 0 0 1.47E-05 0 0
R/C 19224 Fn3-27 42 rs746014932 0.6981 -1.892 1.0 N 0.907 0.462 0.604474940213 gnomAD-4.0.0 1.30575E-05 None None None None N None 4.01027E-05 5.05034E-05 None 0 0 None 0 0 1.10408E-05 0 3.21048E-05
R/H 19224 Fn3-27 42 rs779279322 0.6669 -2.944 1.0 N 0.726 0.539 None gnomAD-2.1.1 2.21E-05 None None None None N None 8.52E-05 0 None 0 1.06758E-04 None 3.45E-05 None 0 8.07E-06 0
R/H 19224 Fn3-27 42 rs779279322 0.6669 -2.944 1.0 N 0.726 0.539 None gnomAD-3.1.2 3.95E-05 None None None None N None 9.66E-05 0 0 0 3.885E-04 None 0 0 0 0 0
R/H 19224 Fn3-27 42 rs779279322 0.6669 -2.944 1.0 N 0.726 0.539 None gnomAD-4.0.0 2.79795E-05 None None None None N None 5.34616E-05 5.04999E-05 None 0 9.00171E-05 None 0 0 2.71771E-05 1.11431E-05 1.60524E-05
R/L 19224 Fn3-27 42 None 0.9092 None 1.0 N 0.743 0.479 0.647476214077 gnomAD-4.0.0 6.86645E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01315E-07 0 0
R/Q 19324 Fn3-28 41 rs186809500 0.6033 -1.171 1.0 N 0.689 0.515 None gnomAD-2.1.1 7.24E-05 None None None None N None 0 5.8E-05 None 0 8.37895E-04 None 3.27E-05 None 0 0 0
R/Q 19324 Fn3-28 41 rs186809500 0.6033 -1.171 1.0 N 0.689 0.515 None gnomAD-3.1.2 5.26E-05 None None None None N None 7.24E-05 0 0 0 9.73141E-04 None 0 0 0 0 0
R/Q 19324 Fn3-28 41 rs186809500 0.6033 -1.171 1.0 N 0.689 0.515 None 1000 genomes 5.99042E-04 None None None None N None 0 0 None None 3E-03 0 None None None 0 None
R/Q 19324 Fn3-28 41 rs186809500 0.6033 -1.171 1.0 N 0.689 0.515 None gnomAD-4.0.0 2.35542E-05 None None None None N None 5.33433E-05 3.33556E-05 None 0 4.24486E-04 None 0 0 4.23901E-06 1.09844E-05 1.12054E-04
R/W 19324 Fn3-28 41 rs1203435642 0.9211 -0.844 1.0 N 0.887 0.601 0.695533483703 gnomAD-2.1.1 8.05E-06 None None None None N None 0 2.9E-05 None 0 0 None 3.27E-05 None 0 0 0
R/W 19324 Fn3-28 41 rs1203435642 0.9211 -0.844 1.0 N 0.887 0.601 0.695533483703 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/W 19324 Fn3-28 41 rs1203435642 0.9211 -0.844 1.0 N 0.887 0.601 0.695533483703 gnomAD-4.0.0 6.81886E-06 None None None None N None 0 1.66828E-05 None 0 2.23374E-05 None 0 0 5.93459E-06 1.09861E-05 1.60128E-05
R/K 19618 Fn3-30 40 None 0.1399 None None N 0.143 0.125 0.243398259712 gnomAD-4.0.0 1.36874E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79923E-06 0 0
R/T 19618 Fn3-30 40 None 0.9424 None 0.324 N 0.513 0.338 0.314716216878 gnomAD-4.0.0 1.36874E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79923E-06 0 0
R/T 19917 Fn3-32 41 None 0.6818 None 0.117 D 0.467 0.162 0.215869574891 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
R/P 20311 Fn3-35 41 rs373062007 0.9971 None 1.0 N 0.877 0.551 0.593086074022 gnomAD-4.0.0 1.37439E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80692E-06 0 0
R/Q 20311 Fn3-35 41 rs373062007 0.2682 -0.976 1.0 N 0.681 0.485 0.235664433957 gnomAD-2.1.1 8.97E-05 None None None None N None 0 0 None 0 9.28984E-04 None 1.98216E-04 None 0 7.85E-06 0
R/Q 20311 Fn3-35 41 rs373062007 0.2682 -0.976 1.0 N 0.681 0.485 0.235664433957 gnomAD-3.1.2 7.89E-05 None None None None N None 0 0 0 0 1.16234E-03 None 9.42E-05 0 1.47E-05 8.28844E-04 0
R/Q 20311 Fn3-35 41 rs373062007 0.2682 -0.976 1.0 N 0.681 0.485 0.235664433957 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
R/Q 20311 Fn3-35 41 rs373062007 0.2682 -0.976 1.0 N 0.681 0.485 0.235664433957 gnomAD-4.0.0 4.60382E-05 None None None None N None 0 0 None 0 4.4839E-04 None 4.69616E-05 1.65837E-04 6.8095E-06 3.5264E-04 1.60808E-04
R/C 20609 Fn3-37 41 rs786205389 0.7764 None 1.0 N 0.895 0.456 0.627389779515 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
R/C 20609 Fn3-37 41 rs786205389 0.7764 None 1.0 N 0.895 0.456 0.627389779515 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
R/C 20609 Fn3-37 41 rs786205389 0.7764 None 1.0 N 0.895 0.456 0.627389779515 gnomAD-4.0.0 4.15323E-05 None None None None N None 0 0 None 0 0 None 0 0 5.08667E-05 1.09801E-05 9.60892E-05
R/H 20609 Fn3-37 41 rs372546292 0.7139 -2.435 1.0 N 0.768 0.506 None gnomAD-2.1.1 2.01E-05 None None None None N None 1.29216E-04 8.71E-05 None 0 0 None 0 None 0 0 0
R/H 20609 Fn3-37 41 rs372546292 0.7139 -2.435 1.0 N 0.768 0.506 None gnomAD-3.1.2 3.95E-05 None None None None N None 7.25E-05 6.55E-05 0 0 0 None 0 0 2.94E-05 0 0
R/H 20609 Fn3-37 41 rs372546292 0.7139 -2.435 1.0 N 0.768 0.506 None gnomAD-4.0.0 1.30178E-05 None None None None N None 4.00812E-05 6.67267E-05 None 0 0 None 0 0 1.1021E-05 0 1.60143E-05
R/S 20708 Fn3-38 41 rs377175428 0.9291 -2.108 0.201 N 0.446 0.192 0.200317383148 gnomAD-2.1.1 8.08E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.95E-06 0
R/S 20708 Fn3-38 41 rs377175428 0.9291 -2.108 0.201 N 0.446 0.192 0.200317383148 gnomAD-4.0.0 4.10639E-06 None None None None N None 0 2.23714E-05 None 0 0 None 0 0 3.59857E-06 0 1.65684E-05
C/S 20904 Fn3-39 41 rs866862450 0.7556 -1.617 0.904 N 0.645 0.388 0.566408210792 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.97E-06 0
C/S 20904 Fn3-39 41 rs866862450 0.7556 -1.617 0.904 N 0.645 0.388 0.566408210792 gnomAD-4.0.0 1.59817E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86115E-06 0 0
K/N 21003 Fn3-40 41 rs794729472 0.9718 None 1.0 N 0.741 0.28 0.215869574891 gnomAD-4.0.0 7.52863E-06 None None None None N None 0 0 None 0 0 None 0 0 9.89611E-06 0 0
R/C 21306 Fn3-42 41 rs773942316 0.7137 -1.667 1.0 N 0.898 0.46 0.590936018357 gnomAD-2.1.1 3.23E-05 None None None None N None 0 0 None 0 0 None 2.28818E-04 None 0 8.94E-06 0
R/C 21306 Fn3-42 41 rs773942316 0.7137 -1.667 1.0 N 0.898 0.46 0.590936018357 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07727E-04 0
R/C 21306 Fn3-42 41 rs773942316 0.7137 -1.667 1.0 N 0.898 0.46 0.590936018357 gnomAD-4.0.0 1.98411E-05 None None None None N None 0 0 None 0 0 None 0 0 4.23924E-06 2.85513E-04 1.60226E-05
R/H 21306 Fn3-42 41 rs202240487 0.594 -2.232 1.0 N 0.76 0.445 None gnomAD-2.1.1 1.53426E-03 None None None None N None 4.14E-05 2.84E-05 None 0 0 None 1.33041E-02 None 0 1.33578E-04 2.81532E-04
R/H 21306 Fn3-42 41 rs202240487 0.594 -2.232 1.0 N 0.76 0.445 None gnomAD-3.1.2 5.00013E-04 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.47124E-04 1.3278E-02 0
R/H 21306 Fn3-42 41 rs202240487 0.594 -2.232 1.0 N 0.76 0.445 None 1000 genomes 3.19489E-03 None None None None N None 0 0 None None 0 0 None None None 1.64E-02 None
R/H 21306 Fn3-42 41 rs202240487 0.594 -2.232 1.0 N 0.76 0.445 None gnomAD-4.0.0 9.64633E-04 None None None None N None 6.67022E-05 6.672E-05 None 0 0 None 0 0 2.56895E-04 1.31556E-02 7.36731E-04
R/L 21306 Fn3-42 41 rs202240487 0.9146 -0.935 1.0 N 0.78 0.507 0.573237765134 gnomAD-2.1.1 4.04E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
R/L 21306 Fn3-42 41 rs202240487 0.9146 -0.935 1.0 N 0.78 0.507 0.573237765134 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
R/L 21306 Fn3-42 41 rs202240487 0.9146 -0.935 1.0 N 0.78 0.507 0.573237765134 gnomAD-4.0.0 3.09994E-06 None None None None N None 4.00855E-05 0 None 0 0 None 0 0 0 0 3.20431E-05
C/R 21600 Fn3-44 42 rs1436243584 0.4184 -1.038 0.99 N 0.795 0.42 0.726150275566 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
C/R 21600 Fn3-44 42 rs1436243584 0.4184 -1.038 0.99 N 0.795 0.42 0.726150275566 gnomAD-4.0.0 1.36869E-06 None None None None N None 0 0 None 0 0 None 0 1.73551E-04 0 1.1595E-05 0
C/F 21797 Fn3-46 41 rs886042894 0.2636 None 0.863 N 0.747 0.279 0.727300299738 gnomAD-4.0.0 4.80084E-06 None None None None N None 0 0 None 0 0 None 0 0 5.40467E-06 0 1.66118E-05
C/G 21797 Fn3-46 41 rs375830234 0.2986 -1.928 0.002 N 0.627 0.273 None gnomAD-2.1.1 6.17E-05 None None None None N None 6.66E-05 0 None 0 0 None 0 None 0 1.2756E-04 0
C/G 21797 Fn3-46 41 rs375830234 0.2986 -1.928 0.002 N 0.627 0.273 None gnomAD-3.1.2 5.92E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.0295E-04 0 0
C/G 21797 Fn3-46 41 rs375830234 0.2986 -1.928 0.002 N 0.627 0.273 None gnomAD-4.0.0 5.15397E-05 None None None None N None 2.67201E-05 0 None 0 0 None 0 0 6.78957E-05 0 1.60488E-05
C/Y 21797 Fn3-46 41 rs886042894 0.3236 None 0.975 N 0.727 0.32 0.637172401323 gnomAD-4.0.0 2.0575E-06 None None None None N None 0 4.50796E-05 None 0 0 None 0 0 0 0 1.66118E-05
R/C 21996 Fn3-47 41 rs577114038 0.7714 -1.705 0.252 N 0.468 0.369 None gnomAD-2.1.1 1.07438E-04 None None None None N None 4.14E-05 5.67247E-04 None 0 0 None 0 None 0 6.27E-05 1.40885E-04
R/C 21996 Fn3-47 41 rs577114038 0.7714 -1.705 0.252 N 0.468 0.369 None gnomAD-3.1.2 4.6E-05 None None None None N None 9.65E-05 1.31079E-04 0 0 0 None 0 0 1.47E-05 0 0
R/C 21996 Fn3-47 41 rs577114038 0.7714 -1.705 0.252 N 0.468 0.369 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
R/C 21996 Fn3-47 41 rs577114038 0.7714 -1.705 0.252 N 0.468 0.369 None gnomAD-4.0.0 4.89799E-05 None None None None N None 1.06707E-04 4.67025E-04 None 0 0 None 0 1.6518E-04 3.30693E-05 1.09849E-05 3.20318E-05
R/H 21996 Fn3-47 41 rs374489349 0.8354 -2.535 1.0 N 0.533 0.469 None gnomAD-2.1.1 3.58E-05 None None None None N None 0 0 None 0 5.19E-05 None 0 None 0 5.49E-05 2.81928E-04
R/H 21996 Fn3-47 41 rs374489349 0.8354 -2.535 1.0 N 0.533 0.469 None gnomAD-3.1.2 3.29E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 5.89E-05 0 0
R/H 21996 Fn3-47 41 rs374489349 0.8354 -2.535 1.0 N 0.533 0.469 None gnomAD-4.0.0 4.58827E-05 None None None None N None 1.33604E-05 1.66839E-05 None 0 4.47808E-05 None 0 0 5.76585E-05 0 3.20451E-05
R/Q 22095 Fn3-48 41 rs745677076 0.5188 -1.237 0.994 N 0.544 0.338 0.267299060538 gnomAD-2.1.1 2.82E-05 None None None None N None 6.48E-05 0 None 0 1.1162E-04 None 3.27E-05 None 0 2.67E-05 0
R/Q 22095 Fn3-48 41 rs745677076 0.5188 -1.237 0.994 N 0.544 0.338 0.267299060538 gnomAD-4.0.0 6.16E-06 None None None None N None 5.98122E-05 0 None 0 2.52105E-05 None 0 0 3.59865E-06 1.15953E-05 1.65722E-05
R/W 22095 Fn3-48 41 rs571093313 0.8666 -0.879 1.0 N 0.721 0.46 0.443285836454 gnomAD-2.1.1 6.86E-05 None None None None N None 0 3.18896E-04 None 0 2.79205E-04 None 0 None 0 8.92E-06 0
R/W 22095 Fn3-48 41 rs571093313 0.8666 -0.879 1.0 N 0.721 0.46 0.443285836454 gnomAD-3.1.2 2.63E-05 None None None None N None 0 6.57E-05 0 0 5.83885E-04 None 0 0 0 0 0
R/W 22095 Fn3-48 41 rs571093313 0.8666 -0.879 1.0 N 0.721 0.46 0.443285836454 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
R/W 22095 Fn3-48 41 rs571093313 0.8666 -0.879 1.0 N 0.721 0.46 0.443285836454 gnomAD-4.0.0 2.54191E-05 None None None None N None 0 2.50183E-04 None 0 1.33929E-04 None 0 1.98282E-03 5.08713E-06 0 3.20246E-05
R/C 22394 Fn3-50 41 rs1388705607 0.8097 None 1.0 N 0.9 0.6 0.578489777024 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 22394 Fn3-50 41 rs1388705607 0.8097 None 1.0 N 0.9 0.6 0.578489777024 gnomAD-4.0.0 1.23976E-06 None None None None N None 0 0 None 0 0 None 0 0 8.47817E-07 1.09796E-05 0
R/H 22394 Fn3-50 41 rs777333661 0.6691 -2.602 1.0 N 0.778 0.553 0.427940940899 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
R/H 22394 Fn3-50 41 rs777333661 0.6691 -2.602 1.0 N 0.778 0.553 0.427940940899 gnomAD-4.0.0 1.02657E-05 None None None None N None 2.99079E-05 0 None 0 0 None 0 1.73611E-04 1.16959E-05 0 0
R/P 22394 Fn3-50 41 None 0.9991 None 1.0 D 0.895 0.586 0.525258673147 gnomAD-4.0.0 6.84381E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99683E-07 0 0
R/S 22394 Fn3-50 41 None 0.9946 None 1.0 N 0.787 0.561 0.415055319159 gnomAD-4.0.0 6.84381E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.1595E-05 0
R/G 22881 Fn3-54 41 None 0.7342 None 0.71 N 0.532 0.381 0.470484629704 gnomAD-4.0.0 9.58267E-06 None None None None N None 0 0 None 0 0 None 0 0 1.25953E-05 0 0
R/Q 22881 Fn3-54 41 rs772700244 0.1753 -1.407 0.068 N 0.274 0.211 0.163833314356 gnomAD-2.1.1 3.63E-05 None None None None N None 0 1.16131E-04 None 0 5.6E-05 None 3.27E-05 None 0 2.68E-05 0
R/Q 22881 Fn3-54 41 rs772700244 0.1753 -1.407 0.068 N 0.274 0.211 0.163833314356 gnomAD-4.0.0 1.71113E-05 None None None None N None 0 8.94734E-05 None 0 2.52512E-05 None 1.87631E-05 3.47464E-04 1.34947E-05 1.15993E-05 1.65717E-05
R/K 23080 Fn3-55 41 rs949990037 0.5558 -1.414 0.025 N 0.194 0.26 0.280181792013 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
R/K 23080 Fn3-55 41 rs949990037 0.5558 -1.414 0.025 N 0.194 0.26 0.280181792013 gnomAD-4.0.0 1.59216E-06 None None None None N None 0 2.28666E-05 None 0 0 None 0 0 0 0 0
R/G 23179 Fn3-56 41 None 0.8808 None 0.117 N 0.519 0.359 0.385743280973 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/K 23179 Fn3-56 41 None 0.1382 None None N 0.156 0.102 0.250039746154 gnomAD-4.0.0 2.73712E-06 None None None None N None 0 0 None 0 0 None 0 6.93963E-04 0 0 0
R/T 23179 Fn3-56 41 rs763091757 0.9324 -1.734 0.117 N 0.483 0.23 0.286465849087 gnomAD-2.1.1 8.04E-06 None None None None N None 0 5.79E-05 None 0 0 None 0 None 0 0 0
R/T 23179 Fn3-56 41 rs763091757 0.9324 -1.734 0.117 N 0.483 0.23 0.286465849087 gnomAD-4.0.0 2.73712E-06 None None None None N None 0 6.70841E-05 None 0 0 None 0 0 0 0 1.65673E-05
R/C 23475 Fn3-58 41 rs761442543 0.8427 -2.027 1.0 N 0.754 0.471 0.612445847935 gnomAD-2.1.1 2.5E-05 None None None None N None 0 2.83E-05 None 0 0 None 3.27E-05 None 0 3.13E-05 1.40489E-04
R/C 23475 Fn3-58 41 rs761442543 0.8427 -2.027 1.0 N 0.754 0.471 0.612445847935 gnomAD-3.1.2 3.29E-05 None None None None N None 0 6.56E-05 0 0 0 None 0 0 5.88E-05 0 0
R/C 23475 Fn3-58 41 rs761442543 0.8427 -2.027 1.0 N 0.754 0.471 0.612445847935 gnomAD-4.0.0 2.66528E-05 None None None None N None 0 3.33545E-05 None 0 0 None 0 0 3.39089E-05 1.09796E-05 0
R/H 23475 Fn3-58 41 rs370257707 0.791 -2.676 0.999 N 0.587 0.41 None gnomAD-2.1.1 3.22E-05 None None None None N None 8.27E-05 0 None 0 5.15E-05 None 0 None 0 4.7E-05 0
R/H 23475 Fn3-58 41 rs370257707 0.791 -2.676 0.999 N 0.587 0.41 None gnomAD-3.1.2 3.95E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 7.36E-05 0 0
R/H 23475 Fn3-58 41 rs370257707 0.791 -2.676 0.999 N 0.587 0.41 None gnomAD-4.0.0 7.37575E-05 None None None None N None 1.33526E-05 0 None 0 2.23254E-05 None 0 0 9.40973E-05 0 9.6083E-05
Q/H 23572 Fn3-59 41 rs747703704 0.6004 -1.415 1.0 N 0.697 0.449 0.241664281697 gnomAD-2.1.1 3.57E-05 None None None None N None 0 0 None 0 5.14192E-04 None 0 None 0 0 0
Q/H 23572 Fn3-59 41 rs747703704 0.6004 -1.415 1.0 N 0.697 0.449 0.241664281697 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 3.86548E-04 None 0 0 0 0 0
Q/H 23572 Fn3-59 41 rs747703704 0.6004 -1.415 1.0 N 0.697 0.449 0.241664281697 gnomAD-4.0.0 6.84288E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.1595E-05 0
R/Q 23767 Fn3-60 42 rs370516890 0.3939 -1.456 1.0 N 0.677 0.451 None gnomAD-2.1.1 1.07924E-04 None None None None N None 1.6592E-04 0 None 0 5.19E-05 None 6.55E-05 None 4.01E-05 1.73831E-04 0
R/Q 23767 Fn3-60 42 rs370516890 0.3939 -1.456 1.0 N 0.677 0.451 None gnomAD-3.1.2 1.18429E-04 None None None None N None 2.17381E-04 6.56E-05 0 0 0 None 0 0 1.17661E-04 0 0
R/Q 23767 Fn3-60 42 rs370516890 0.3939 -1.456 1.0 N 0.677 0.451 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
R/Q 23767 Fn3-60 42 rs370516890 0.3939 -1.456 1.0 N 0.677 0.451 None gnomAD-4.0.0 1.09125E-04 None None None None N None 1.60034E-04 1.66789E-05 None 0 0 None 1.56514E-05 0 1.2634E-04 7.69197E-05 9.61138E-05
R/W 23767 Fn3-60 42 rs532157196 0.8951 -1.141 1.0 N 0.888 0.563 0.465806656444 gnomAD-2.1.1 8.11E-06 None None None None N None 6.49E-05 0 None 0 0 None 0 None 0 9E-06 0
R/W 23767 Fn3-60 42 rs532157196 0.8951 -1.141 1.0 N 0.888 0.563 0.465806656444 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
R/W 23767 Fn3-60 42 rs532157196 0.8951 -1.141 1.0 N 0.888 0.563 0.465806656444 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
R/W 23767 Fn3-60 42 rs532157196 0.8951 -1.141 1.0 N 0.888 0.563 0.465806656444 gnomAD-4.0.0 5.58005E-06 None None None None N None 4.00053E-05 0 None 0 2.23884E-05 None 0 0 3.39164E-06 0 1.60174E-05
R/K 23964 Fn3-62 41 rs770679732 0.1198 -1.275 0.046 N 0.211 0.148 0.231873229951 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
R/K 23964 Fn3-62 41 rs770679732 0.1198 -1.275 0.046 N 0.211 0.148 0.231873229951 gnomAD-4.0.0 1.59287E-06 None None None None N None 0 2.28728E-05 None 0 0 None 0 0 0 0 0
R/C 24163 Fn3-63 42 rs778284888 0.6731 -1.685 1.0 N 0.795 0.415 0.709351898144 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 2.87687E-04 0 0
R/C 24163 Fn3-63 42 rs778284888 0.6731 -1.685 1.0 N 0.795 0.415 0.709351898144 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 1.93648E-04 None 9.43E-05 0 0 0 0
R/C 24163 Fn3-63 42 rs778284888 0.6731 -1.685 1.0 N 0.795 0.415 0.709351898144 gnomAD-4.0.0 1.39829E-05 None None None None N None 0 0 None 0 4.5901E-05 None 1.66141E-05 0 1.33022E-05 2.87002E-05 1.73503E-05
R/G 24163 Fn3-63 42 None 0.9642 None 0.954 N 0.643 0.509 0.691025755046 gnomAD-4.0.0 7.40859E-07 None None None None N None 0 0 None 0 0 None 2.01654E-05 0 0 0 0
R/H 24163 Fn3-63 42 rs374712231 0.7766 -2.46 0.997 N 0.595 0.573 None gnomAD-2.1.1 3.48E-05 None None None None N None 8.64E-05 0 None 0 6.07E-05 None 7.27E-05 None 0 3.01E-05 0
R/H 24163 Fn3-63 42 rs374712231 0.7766 -2.46 0.997 N 0.595 0.573 None gnomAD-3.1.2 5.92E-05 None None None None N None 9.65E-05 0 0 0 3.87297E-04 None 0 0 4.41E-05 0 0
R/H 24163 Fn3-63 42 rs374712231 0.7766 -2.46 0.997 N 0.595 0.573 None 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 1E-03 1E-03 None None None 0 None
R/H 24163 Fn3-63 42 rs374712231 0.7766 -2.46 0.997 N 0.595 0.573 None gnomAD-4.0.0 4.93351E-05 None None None None N None 1.25874E-04 0 None 0 9.20217E-05 None 0 0 5.14811E-05 2.89243E-05 1.73557E-05
R/L 24163 Fn3-63 42 rs374712231 0.9414 -1.027 0.954 N 0.643 0.532 None gnomAD-2.1.1 9.93E-06 None None None None N None 0 0 None 0 0 None 0 None 0 2E-05 0
R/L 24163 Fn3-63 42 rs374712231 0.9414 -1.027 0.954 N 0.643 0.532 None gnomAD-4.0.0 1.48394E-06 None None None None N None 0 0 None 0 0 None 0 0 1.8892E-06 0 0
R/S 24163 Fn3-63 42 None 0.9936 None 0.954 N 0.621 0.485 0.473065174198 gnomAD-4.0.0 2.22258E-06 None None None None N None 0 0 None 0 0 None 0 0 2.83116E-06 0 0
R/C 24262 Fn3-64 41 rs576976296 0.4297 -1.584 1.0 N 0.759 0.401 0.613436686781 gnomAD-2.1.1 1.82E-05 None None None None N None 0 0 None 0 0 None 6.13E-05 None 0 2.84E-05 0
R/C 24262 Fn3-64 41 rs576976296 0.4297 -1.584 1.0 N 0.759 0.401 0.613436686781 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 2.07727E-04 0
R/C 24262 Fn3-64 41 rs576976296 0.4297 -1.584 1.0 N 0.759 0.401 0.613436686781 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
R/C 24262 Fn3-64 41 rs576976296 0.4297 -1.584 1.0 N 0.759 0.401 0.613436686781 gnomAD-4.0.0 4.5562E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25303E-06 1.29992E-05 0
R/H 24262 Fn3-64 41 rs372390659 0.2335 -2.116 0.385 N 0.263 0.264 None gnomAD-2.1.1 4.09E-05 None None None None N None 4.26E-05 0 None 0 0 None 1.84049E-04 None 0 4.74E-05 0
R/H 24262 Fn3-64 41 rs372390659 0.2335 -2.116 0.385 N 0.263 0.264 None gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 2.07297E-04 0
R/H 24262 Fn3-64 41 rs372390659 0.2335 -2.116 0.385 N 0.263 0.264 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
R/H 24262 Fn3-64 41 rs372390659 0.2335 -2.116 0.385 N 0.263 0.264 None gnomAD-4.0.0 2.7327E-05 None None None None N None 1.37756E-05 0 None 0 0 None 0 1.75747E-04 2.71316E-05 1.03839E-04 1.69045E-05
R/S 24262 Fn3-64 41 None 0.9778 None 0.975 N 0.597 0.346 0.350088858571 gnomAD-4.0.0 7.2233E-07 None None None None N None 0 0 None 0 0 None 0 0 9.30868E-07 0 0
R/Q 24559 Fn3-66 41 rs780238881 0.817 -1.267 1.0 N 0.673 0.434 0.304435445954 gnomAD-2.1.1 2.42E-05 None None None None N None 0 0 None 0 0 None 1.30967E-04 None 0 1.78E-05 0
R/Q 24559 Fn3-66 41 rs780238881 0.817 -1.267 1.0 N 0.673 0.434 0.304435445954 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/Q 24559 Fn3-66 41 rs780238881 0.817 -1.267 1.0 N 0.673 0.434 0.304435445954 gnomAD-4.0.0 1.86088E-05 None None None None N None 0 0 None 0 1.56607E-04 None 0 0 4.24193E-06 1.64813E-04 4.80815E-05
R/W 24559 Fn3-66 41 rs367904757 0.961 -0.937 1.0 N 0.888 0.53 None gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
R/W 24559 Fn3-66 41 rs367904757 0.961 -0.937 1.0 N 0.888 0.53 None gnomAD-3.1.2 1.32E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 1.47E-05 0 0
R/W 24559 Fn3-66 41 rs367904757 0.961 -0.937 1.0 N 0.888 0.53 None gnomAD-4.0.0 6.20327E-06 None None None None N None 5.34559E-05 0 None 0 0 None 0 0 5.09029E-06 0 0
Q/K 24656 Fn3-67 41 rs763473286 0.166 -0.2 0.999 N 0.479 0.409 0.254244900254 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.61E-05 None 0 None 0 0 0
Q/K 24656 Fn3-67 41 rs763473286 0.166 -0.2 0.999 N 0.479 0.409 0.254244900254 gnomAD-4.0.0 1.59216E-06 None None None None N None 0 0 None 0 2.78211E-05 None 0 0 0 0 0
R/L 24849 Fn3-68 42 None 0.9419 None 0.954 N 0.606 0.501 0.516050471323 gnomAD-4.0.0 6.84466E-07 None None None None N None 0 0 None 0 2.53062E-05 None 0 0 0 0 0
R/Q 24849 Fn3-68 42 rs745488276 0.5676 -1.306 0.59 N 0.317 0.362 0.229924730088 gnomAD-2.1.1 2.83E-05 None None None None N None 0 1.16239E-04 None 0 0 None 3.27E-05 None 0 1.8E-05 0
R/Q 24849 Fn3-68 42 rs745488276 0.5676 -1.306 0.59 N 0.317 0.362 0.229924730088 gnomAD-4.0.0 9.5825E-06 None None None None N None 0 8.94815E-05 None 0 0 None 0 0 7.19694E-06 1.15964E-05 1.65772E-05
R/W 24849 Fn3-68 42 rs727503562 0.9001 -1.061 1.0 N 0.671 0.571 0.369495900351 gnomAD-2.1.1 2.51E-05 None None None None N None 2.07159E-04 0 None 0 0 None 0 None 0 1.58E-05 0
R/W 24849 Fn3-68 42 rs727503562 0.9001 -1.061 1.0 N 0.671 0.571 0.369495900351 gnomAD-3.1.2 4.6E-05 None None None None N None 1.44872E-04 0 0 0 0 None 0 0 1.47E-05 0 0
R/W 24849 Fn3-68 42 rs727503562 0.9001 -1.061 1.0 N 0.671 0.571 0.369495900351 gnomAD-4.0.0 9.29914E-06 None None None None N None 1.20221E-04 0 None 0 0 None 0 1.64636E-04 3.39105E-06 1.09808E-05 0
K/T 24948 Fn3-69 41 rs1263875134 0.9865 None 0.988 D 0.741 0.476 0.397691132334 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/T 24948 Fn3-69 41 rs1263875134 0.9865 None 0.988 D 0.741 0.476 0.397691132334 gnomAD-4.0.0 2.56321E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78785E-06 0 0
K/E 25046 Fn3-70 41 None 0.7687 None 0.805 N 0.457 0.228 0.260735089382 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
K/R 25046 Fn3-70 41 None 0.0808 None 0.025 N 0.381 0.1 0.27855597813 gnomAD-4.0.0 1.36871E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79931E-06 0 0
K/T 25046 Fn3-70 41 rs759445513 0.8492 -1.796 0.967 N 0.659 0.396 0.363356657567 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
R/K 25245 Fn3-71 42 rs397517701 0.4567 -1.461 0.944 N 0.459 0.205 None gnomAD-2.1.1 2.51E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 4.73E-05 0
R/K 25245 Fn3-71 42 rs397517701 0.4567 -1.461 0.944 N 0.459 0.205 None gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
R/K 25245 Fn3-71 42 rs397517701 0.4567 -1.461 0.944 N 0.459 0.205 None gnomAD-4.0.0 1.61187E-05 None None None None N None 1.33547E-05 0 None 0 0 None 0 1.64582E-04 1.69549E-05 3.29417E-05 1.60195E-05
R/T 25245 Fn3-71 42 rs397517701 0.9833 -1.706 0.892 N 0.601 0.545 0.467585353272 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.97E-06 0
R/T 25245 Fn3-71 42 rs397517701 0.9833 -1.706 0.892 N 0.601 0.545 0.467585353272 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/T 25245 Fn3-71 42 rs397517701 0.9833 -1.706 0.892 N 0.601 0.545 0.467585353272 gnomAD-4.0.0 2.47979E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39097E-06 0 0
R/L 25344 Fn3-72 41 rs556179271 0.8636 -1.088 0.954 N 0.645 0.478 0.354822389136 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
R/L 25344 Fn3-72 41 rs556179271 0.8636 -1.088 0.954 N 0.645 0.478 0.354822389136 gnomAD-4.0.0 4.10606E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39754E-06 0 0
R/P 25344 Fn3-72 41 rs556179271 0.999 -1.67 0.993 D 0.759 0.488 0.489036454283 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
R/Q 25344 Fn3-72 41 None 0.3882 -1.166 0.994 N 0.571 0.335 0.300449992093 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
R/Q 25344 Fn3-72 41 None 0.3882 -1.166 0.994 N 0.571 0.335 0.300449992093 gnomAD-3.1.2 3.29E-05 None None None None N None 0 3.27783E-04 0 0 0 None 0 0 0 0 0
R/Q 25344 Fn3-72 41 None 0.3882 -1.166 0.994 N 0.571 0.335 0.300449992093 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
R/Q 25344 Fn3-72 41 None 0.3882 -1.166 0.994 N 0.571 0.335 0.300449992093 gnomAD-4.0.0 1.48754E-05 None None None None N None 0 2.0006E-04 None 0 2.23244E-05 None 0 0 8.47759E-06 0 1.60097E-05
R/W 25344 Fn3-72 41 rs371696090 0.6834 -0.831 1.0 N 0.703 0.473 None gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 5.58E-05 None 9.81E-05 None 0 8.91E-06 0
R/W 25344 Fn3-72 41 rs371696090 0.6834 -0.831 1.0 N 0.703 0.473 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.44E-05 0 0 0 0
R/W 25344 Fn3-72 41 rs371696090 0.6834 -0.831 1.0 N 0.703 0.473 None gnomAD-4.0.0 6.81864E-06 None None None None N None 0 0 None 0 2.23164E-05 None 1.56323E-05 0 2.54328E-06 6.58877E-05 0
C/Y 25445 Fn3-73 41 rs2154168053 0.2623 None 0.99 N 0.727 0.381 0.686824916271 gnomAD-4.0.0 1.3003E-05 None None None None N None 0 0 None 0 0 None 0 0 1.7092E-05 0 0
R/C 25641 Fn3-74 41 rs549745098 0.6887 -1.903 1.0 N 0.782 0.473 0.670176712172 gnomAD-2.1.1 2.05E-05 None None None None N None 0 0 None 0 2.23864E-04 None 0 None 0 9E-06 0
R/C 25641 Fn3-74 41 rs549745098 0.6887 -1.903 1.0 N 0.782 0.473 0.670176712172 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 1.93424E-04 None 0 0 1.47E-05 0 0
R/C 25641 Fn3-74 41 rs549745098 0.6887 -1.903 1.0 N 0.782 0.473 0.670176712172 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
R/C 25641 Fn3-74 41 rs549745098 0.6887 -1.903 1.0 N 0.782 0.473 0.670176712172 gnomAD-4.0.0 6.84366E-06 None None None None N None 0 0 None 0 8.93296E-05 None 0 0 5.94943E-06 0 0
R/H 25641 Fn3-74 41 rs369707906 0.6865 -2.602 0.999 N 0.569 0.45 None gnomAD-2.1.1 6.31795E-04 None None None None N None 4.15E-05 0 None 0 0 None 5.74398E-03 None 0 3.17E-05 1.43802E-04
R/H 25641 Fn3-74 41 rs369707906 0.6865 -2.602 0.999 N 0.569 0.45 None gnomAD-3.1.2 2.89348E-04 None None None None N None 9.65E-05 0 0 0 0 None 0 0 5.88E-05 7.45033E-03 0
R/H 25641 Fn3-74 41 rs369707906 0.6865 -2.602 0.999 N 0.569 0.45 None 1000 genomes 1.99681E-03 None None None None N None 0 0 None None 0 0 None None None 1.02E-02 None
R/H 25641 Fn3-74 41 rs369707906 0.6865 -2.602 0.999 N 0.569 0.45 None gnomAD-4.0.0 4.96591E-04 None None None None N None 1.20588E-04 0 None 0 0 None 0 1.66168E-04 2.02316E-04 5.84711E-03 4.02188E-04
R/L 25641 Fn3-74 41 None 0.9417 None 0.996 N 0.679 0.454 0.681492719615 gnomAD-4.0.0 6.87392E-07 None None None None N None 0 0 None 0 0 None 1.87913E-05 0 0 0 0
Q/K 25738 Fn3-75 41 None 0.1368 None 0.984 N 0.431 0.208 0.1749357433 gnomAD-4.0.0 6.8438E-07 None None None None N None 2.99025E-05 0 None 0 0 None 0 0 0 0 0
R/C 26128 Fn3-78 41 rs373530641 0.3537 -1.557 1.0 N 0.758 0.42 None gnomAD-2.1.1 1.61E-05 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 2.68E-05 0
R/C 26128 Fn3-78 41 rs373530641 0.3537 -1.557 1.0 N 0.758 0.42 None gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/C 26128 Fn3-78 41 rs373530641 0.3537 -1.557 1.0 N 0.758 0.42 None gnomAD-4.0.0 2.48008E-05 None None None None N None 2.6713E-05 0 None 0 0 None 0 0 2.71363E-05 1.09825E-05 8.01025E-05
R/H 26128 Fn3-78 41 rs757957389 0.3482 -2.097 0.999 N 0.613 0.266 None gnomAD-2.1.1 1.43E-05 None None None None N None 8.27E-05 0 None 0 5.15E-05 None 0 None 0 7.84E-06 0
R/H 26128 Fn3-78 41 rs757957389 0.3482 -2.097 0.999 N 0.613 0.266 None gnomAD-3.1.2 3.29E-05 None None None None N None 9.65E-05 6.56E-05 0 0 0 None 0 0 0 0 0
R/H 26128 Fn3-78 41 rs757957389 0.3482 -2.097 0.999 N 0.613 0.266 None gnomAD-4.0.0 9.30003E-06 None None None None N None 6.67735E-05 1.66856E-05 None 0 2.23174E-05 None 0 0 5.93605E-06 0 1.60195E-05
R/L 26128 Fn3-78 41 None 0.6874 None 0.975 N 0.681 0.46 0.524533156562 gnomAD-4.0.0 6.84556E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15977E-05 0
R/P 26128 Fn3-78 41 rs757957389 0.9977 -1.229 0.996 N 0.797 0.492 0.450248222533 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 1.11769E-04 None 0 None 0 0 0
R/S 26128 Fn3-78 41 None 0.9456 None 0.975 N 0.643 0.388 0.358340041657 gnomAD-4.0.0 1.36911E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79976E-06 0 0
R/L 26327 Fn3-79 42 None 0.9806 None 0.913 N 0.608 0.51 0.592397689306 gnomAD-4.0.0 6.8433E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15953E-05 0
R/Q 26327 Fn3-79 42 rs370367786 0.7777 -1.144 0.999 N 0.475 0.425 None gnomAD-2.1.1 3.94E-05 None None None None N None 8.27E-05 2.83E-05 None 0 0 None 0 None 0 6.28E-05 0
R/Q 26327 Fn3-79 42 rs370367786 0.7777 -1.144 0.999 N 0.475 0.425 None gnomAD-3.1.2 7.23E-05 None None None None N None 1.20697E-04 0 0 0 0 None 0 0 7.35E-05 0 4.78469E-04
R/Q 26327 Fn3-79 42 rs370367786 0.7777 -1.144 0.999 N 0.475 0.425 None gnomAD-4.0.0 5.20647E-05 None None None None N None 9.34929E-05 3.33478E-05 None 0 0 None 0 0 6.18852E-05 0 3.20297E-05
R/I 26426 Fn3-80 41 None 0.9638 None 0.983 D 0.797 0.506 0.596373027241 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/C 26723 Fn3-82 41 rs1412497882 0.8844 -1.993 1.0 N 0.754 0.508 0.359357374593 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.91E-06 0
R/C 26723 Fn3-82 41 rs1412497882 0.8844 -1.993 1.0 N 0.754 0.508 0.359357374593 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 26723 Fn3-82 41 rs1412497882 0.8844 -1.993 1.0 N 0.754 0.508 0.359357374593 gnomAD-4.0.0 1.36352E-05 None None None None N None 0 0 None 0 0 None 1.5623E-05 0 1.44108E-05 2.19582E-05 3.20266E-05
R/H 26723 Fn3-82 41 rs371615296 0.8407 -2.7 0.999 N 0.584 0.534 None gnomAD-2.1.1 2.14E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.91E-05 1.40568E-04
R/H 26723 Fn3-82 41 rs371615296 0.8407 -2.7 0.999 N 0.584 0.534 None gnomAD-3.1.2 3.94E-05 None None None None N None 1.20668E-04 0 0 0 0 None 0 0 1.47E-05 0 0
R/H 26723 Fn3-82 41 rs371615296 0.8407 -2.7 0.999 N 0.584 0.534 None gnomAD-4.0.0 1.6114E-05 None None None None N None 6.67628E-05 0 None 3.37929E-05 0 None 0 1.64582E-04 9.32447E-06 3.29366E-05 8.00692E-05
R/L 26723 Fn3-82 41 None 0.9732 None 0.986 N 0.641 0.506 0.345859378078 gnomAD-4.0.0 6.84275E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99543E-07 0 0
Q/K 26820 Fn3-83 41 None 0.1679 None 0.982 N 0.502 0.3 0.227260227426 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
R/L 27013 Fn3-84 42 rs376374751 0.9496 -1.124 0.922 N 0.614 0.445 0.48300943003 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
R/L 27013 Fn3-84 42 rs376374751 0.9496 -1.124 0.922 N 0.614 0.445 0.48300943003 gnomAD-4.0.0 6.84288E-07 None None None None N None 2.989E-05 0 None 0 0 None 0 0 0 0 0
R/Q 27013 Fn3-84 42 rs376374751 0.6212 -1.349 0.447 N 0.33 0.298 None gnomAD-2.1.1 5.72E-05 None None None None N None 8.27E-05 0 None 9.68E-05 0 None 0 None 4E-05 9.39E-05 0
R/Q 27013 Fn3-84 42 rs376374751 0.6212 -1.349 0.447 N 0.33 0.298 None gnomAD-3.1.2 5.26E-05 None None None None N None 7.25E-05 0 0 0 0 None 0 0 7.35E-05 0 0
R/Q 27013 Fn3-84 42 rs376374751 0.6212 -1.349 0.447 N 0.33 0.298 None gnomAD-4.0.0 4.52448E-05 None None None None N None 8.01496E-05 1.66767E-05 None 0 0 None 1.56216E-05 4.93746E-04 4.91663E-05 0 6.40512E-05
K/E 27112 Fn3-85 41 rs534444792 0.9855 -1.074 0.958 N 0.447 0.397 0.374255764437 gnomAD-2.1.1 8.18E-06 None None None None N None 0 0 None 0 0 None 6.57E-05 None 0 0 0
K/E 27112 Fn3-85 41 rs534444792 0.9855 -1.074 0.958 N 0.447 0.397 0.374255764437 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
K/E 27112 Fn3-85 41 rs534444792 0.9855 -1.074 0.958 N 0.447 0.397 0.374255764437 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
K/E 27112 Fn3-85 41 rs534444792 0.9855 -1.074 0.958 N 0.447 0.397 0.374255764437 gnomAD-4.0.0 5.13197E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.02576E-05 2.84884E-05
K/T 27112 Fn3-85 41 None 0.99 None 0.988 N 0.731 0.511 0.447410926215 gnomAD-4.0.0 1.5946E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86305E-06 0 0
K/E 27210 Fn3-86 41 None 0.8395 None 0.892 N 0.431 0.236 0.28492961333 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
K/T 27210 Fn3-86 41 rs1241055435 0.8915 -1.256 0.967 N 0.708 0.409 0.349429436713 gnomAD-2.1.1 4.08E-06 None None None None N None 0 2.93E-05 None 0 0 None 0 None 0 0 0
K/T 27210 Fn3-86 41 rs1241055435 0.8915 -1.256 0.967 N 0.708 0.409 0.349429436713 gnomAD-4.0.0 1.59473E-06 None None None None N None 0 2.29674E-05 None 0 0 None 0 0 0 0 0
R/K 27410 Fn3-87 42 None 0.5222 None 0.025 N 0.198 0.212 0.229924730088 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
R/P 27509 Fn3-88 41 rs1246168127 0.998 None 1.0 D 0.887 0.476 0.564872276104 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93274E-04 None 0 0 0 0 0
R/P 27509 Fn3-88 41 rs1246168127 0.998 None 1.0 D 0.887 0.476 0.564872276104 gnomAD-4.0.0 6.57601E-06 None None None None N None 0 0 None 0 1.93274E-04 None 0 0 0 0 0
R/Q 27509 Fn3-88 41 rs1246168127 0.3526 -1.083 1.0 N 0.687 0.42 0.358744678677 gnomAD-2.1.1 3.62E-05 None None None None N None 0 2.31723E-04 None 0 0 None 0 None 0 8.88E-06 0
R/Q 27509 Fn3-88 41 rs1246168127 0.3526 -1.083 1.0 N 0.687 0.42 0.358744678677 gnomAD-4.0.0 6.15789E-06 None None None None N None 0 1.56523E-04 None 0 0 None 0 0 1.79897E-06 0 0
R/Q 27806 Fn3-90 41 rs192301247 0.5384 -1.143 1.0 N 0.675 0.421 None gnomAD-2.1.1 1.27E-05 None None None None N None 0 6.25E-05 None 0 0 None 0 None 0 9.17E-06 0
R/Q 27806 Fn3-90 41 rs192301247 0.5384 -1.143 1.0 N 0.675 0.421 None gnomAD-3.1.2 3.94E-05 None None None None N None 2.41E-05 0 0 0 1.92976E-04 None 0 0 4.41E-05 2.06954E-04 0
R/Q 27806 Fn3-90 41 rs192301247 0.5384 -1.143 1.0 N 0.675 0.421 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
R/Q 27806 Fn3-90 41 rs192301247 0.5384 -1.143 1.0 N 0.675 0.421 None gnomAD-4.0.0 1.00189E-05 None None None None N None 1.35186E-05 3.50373E-05 None 0 2.24004E-05 None 0 0 8.5275E-06 2.28133E-05 0
R/C 28491 Fn3-95 42 rs746090724 0.3034 -1.83 1.0 N 0.761 0.412 0.635445006688 gnomAD-2.1.1 5.37E-05 None None None None N None 0 2.83E-05 None 0 0 None 4.57666E-04 None 0 0 0
R/C 28491 Fn3-95 42 rs746090724 0.3034 -1.83 1.0 N 0.761 0.412 0.635445006688 gnomAD-3.1.2 1.97E-05 None None None None N None 0 1.31182E-04 0 0 0 None 0 0 1.47E-05 0 0
R/C 28491 Fn3-95 42 rs746090724 0.3034 -1.83 1.0 N 0.761 0.412 0.635445006688 gnomAD-4.0.0 2.16931E-05 None None None None N None 0 5.00367E-05 None 0 0 None 0 0 2.54291E-06 3.18408E-04 0
R/H 28491 Fn3-95 42 rs373129706 0.3997 -2.483 0.997 D 0.584 0.524 None gnomAD-2.1.1 1.10946E-04 None None None None N None 4.14E-05 0 None 0 1.23571E-03 None 6.54E-05 None 0 3.14E-05 0
R/H 28491 Fn3-95 42 rs373129706 0.3997 -2.483 0.997 D 0.584 0.524 None gnomAD-3.1.2 7.23E-05 None None None None N None 2.41E-05 0 0 0 1.5444E-03 None 0 0 2.94E-05 0 0
R/H 28491 Fn3-95 42 rs373129706 0.3997 -2.483 0.997 D 0.584 0.524 None gnomAD-4.0.0 5.82597E-05 None None None None N None 2.67008E-05 0 None 0 8.70303E-04 None 0 0 3.56E-05 9.88207E-05 3.20277E-05
R/L 28590 Fn3-96 41 None 0.8126 None 1.0 N 0.737 0.577 0.706951834606 gnomAD-4.0.0 2.05277E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69845E-06 0 0
R/P 28590 Fn3-96 41 rs375667028 0.9983 -1.536 1.0 D 0.871 0.691 0.692726414735 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
R/P 28590 Fn3-96 41 rs375667028 0.9983 -1.536 1.0 D 0.871 0.691 0.692726414735 gnomAD-4.0.0 6.84258E-07 None None None None N None 0 0 None 0 2.52258E-05 None 0 0 0 0 0
R/Q 28590 Fn3-96 41 rs375667028 0.2997 -1.037 1.0 N 0.666 0.485 None gnomAD-2.1.1 1.25107E-04 None None None None N None 0 2.83E-05 None 0 0 None 3.27E-05 None 4.80461E-04 1.64255E-04 0
R/Q 28590 Fn3-96 41 rs375667028 0.2997 -1.037 1.0 N 0.666 0.485 None gnomAD-3.1.2 1.1834E-04 None None None None N None 4.83E-05 0 0 0 0 None 5.65504E-04 0 1.47054E-04 0 0
R/Q 28590 Fn3-96 41 rs375667028 0.2997 -1.037 1.0 N 0.666 0.485 None gnomAD-4.0.0 9.04842E-05 None None None None N None 4.0047E-05 1.66733E-05 None 0 0 None 4.37623E-04 0 8.73066E-05 8.78522E-05 4.80415E-05
R/C 28885 Fn3-98 41 rs1702802682 0.7668 None 1.0 D 0.901 0.43 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.43E-05 0 0 0 0
R/C 28885 Fn3-98 41 rs1702802682 0.7668 None 1.0 D 0.901 0.43 None gnomAD-4.0.0 3.09877E-06 None None None None N None 0 0 None 0 0 None 4.68765E-05 0 1.6953E-06 0 0
R/H 28885 Fn3-98 41 rs371539720 0.7392 -2.547 1.0 N 0.766 0.492 None gnomAD-2.1.1 3.57E-05 None None None None N None 4.13E-05 2.83E-05 None 2.89911E-04 0 None 0 None 0 3.9E-05 0
R/H 28885 Fn3-98 41 rs371539720 0.7392 -2.547 1.0 N 0.766 0.492 None gnomAD-3.1.2 3.29E-05 None None None None N None 4.83E-05 6.55E-05 0 2.88018E-04 0 None 0 0 1.47E-05 0 0
R/H 28885 Fn3-98 41 rs371539720 0.7392 -2.547 1.0 N 0.766 0.492 None gnomAD-4.0.0 3.40854E-05 None None None None N None 2.6703E-05 3.334E-05 None 2.0273E-04 0 None 0 0 3.47537E-05 1.09803E-05 4.80338E-05
R/L 28885 Fn3-98 41 rs371539720 0.947 -1.137 1.0 N 0.784 0.465 0.620522651735 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
R/L 28885 Fn3-98 41 rs371539720 0.947 -1.137 1.0 N 0.784 0.465 0.620522651735 gnomAD-4.0.0 6.84255E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99518E-07 0 0
L/P 28982 Fn3-99 41 rs767470225 0.9611 None 0.781 N 0.797 0.308 0.716020962526 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/G 29178 Fn3-100 42 rs1214776587 0.9572 -2.338 1.0 N 0.771 0.609 0.371157983038 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/G 29178 Fn3-100 42 rs1214776587 0.9572 -2.338 1.0 N 0.771 0.609 0.371157983038 gnomAD-4.0.0 1.59103E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
K/N 29277 Fn3-101 41 None 0.9951 None 1.0 N 0.753 0.483 0.202086224978 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
R/C 29375 Fn3-102 41 rs368439674 0.3844 -1.62 0.998 N 0.622 0.426 None gnomAD-2.1.1 8.05E-05 None None None None N None 0 2.9E-05 None 0 7.84753E-04 None 0 None 0 4.44E-05 0
R/C 29375 Fn3-102 41 rs368439674 0.3844 -1.62 0.998 N 0.622 0.426 None gnomAD-3.1.2 9.86E-05 None None None None N None 0 6.5505E-04 0 0 1.9253E-04 None 0 0 5.88E-05 0 0
R/C 29375 Fn3-102 41 rs368439674 0.3844 -1.62 0.998 N 0.622 0.426 None gnomAD-4.0.0 3.16057E-05 None None None None N None 1.33472E-05 1.8337E-04 None 0 2.00947E-04 None 0 1.6442E-04 2.28846E-05 0 3.20225E-05
R/H 29375 Fn3-102 41 rs761246441 0.2919 -2.104 0.047 N 0.297 0.238 0.214338557667 gnomAD-2.1.1 2.41E-05 None None None None N None 0 1.16003E-04 None 0 1.12108E-04 None 0 None 0 0 0
R/H 29375 Fn3-102 41 rs761246441 0.2919 -2.104 0.047 N 0.297 0.238 0.214338557667 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 1.88786E-04 0 0 0 0
R/H 29375 Fn3-102 41 rs761246441 0.2919 -2.104 0.047 N 0.297 0.238 0.214338557667 gnomAD-4.0.0 1.11551E-05 None None None None N None 2.66987E-05 5.00083E-05 None 0 4.46568E-05 None 3.12617E-05 0 6.78063E-06 0 1.60118E-05
R/L 29375 Fn3-102 41 rs761246441 0.7127 None 0.756 N 0.535 0.317 0.457286136841 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/L 29375 Fn3-102 41 rs761246441 0.7127 None 0.756 N 0.535 0.317 0.457286136841 gnomAD-4.0.0 6.57289E-06 None None None None N None 2.41359E-05 0 None 0 0 None 0 0 0 0 0
R/S 29375 Fn3-102 41 None 0.9549 None 0.756 N 0.452 0.351 0.330589388543 gnomAD-4.0.0 6.84235E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99441E-07 0 0
R/C 29574 Fn3-103 42 rs200513274 0.6076 -1.687 1.0 N 0.885 0.374 None gnomAD-2.1.1 2.60645E-04 None None None None N None 1.23957E-04 2.83E-05 None 0 4.10298E-04 None 2.61455E-04 None 0 3.98624E-04 2.80899E-04
R/C 29574 Fn3-103 42 rs200513274 0.6076 -1.687 1.0 N 0.885 0.374 None gnomAD-3.1.2 2.89283E-04 None None None None N None 1.20691E-04 0 0 0 7.72201E-04 None 0 0 5.14555E-04 0 0
R/C 29574 Fn3-103 42 rs200513274 0.6076 -1.687 1.0 N 0.885 0.374 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
R/C 29574 Fn3-103 42 rs200513274 0.6076 -1.687 1.0 N 0.885 0.374 None gnomAD-4.0.0 4.75884E-04 None None None None N None 1.06627E-04 0 None 0 3.79007E-04 None 1.56265E-05 0 5.8059E-04 3.51363E-04 4.00128E-04
R/G 29574 Fn3-103 42 rs200513274 0.9637 -2.568 1.0 N 0.783 0.466 0.614107689767 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/G 29574 Fn3-103 42 rs200513274 0.9637 -2.568 1.0 N 0.783 0.466 0.614107689767 gnomAD-4.0.0 2.05251E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79885E-06 1.15937E-05 0
R/H 29574 Fn3-103 42 rs111727915 0.7671 -2.472 1.0 N 0.787 0.404 None gnomAD-2.1.1 5.3912E-04 None None None None N None 2.06629E-03 9.89819E-04 None 1.74149E-03 0 None 3.27E-05 None 4E-05 3.12627E-04 8.4246E-04
R/H 29574 Fn3-103 42 rs111727915 0.7671 -2.472 1.0 N 0.787 0.404 None gnomAD-3.1.2 8.74057E-04 None None None None N None 2.05096E-03 1.30959E-03 0 1.72911E-03 0 None 0 0 3.0866E-04 0 4.78469E-04
R/H 29574 Fn3-103 42 rs111727915 0.7671 -2.472 1.0 N 0.787 0.404 None 1000 genomes 9.98403E-04 None None None None N None 1.5E-03 2.9E-03 None None 0 1E-03 None None None 0 None
R/H 29574 Fn3-103 42 rs111727915 0.7671 -2.472 1.0 N 0.787 0.404 None gnomAD-4.0.0 3.14762E-04 None None None None N None 1.9855E-03 9.83071E-04 None 1.58773E-03 0 None 1.56226E-05 1.32013E-03 1.70361E-04 6.58733E-05 5.9219E-04
R/L 29673 Fn3-104 41 rs200639218 0.7689 -1.17 1.0 N 0.76 0.544 0.605592448911 gnomAD-2.1.1 1.61E-05 None None None None N None 6.46E-05 2.9E-05 None 0 0 None 0 None 0 1.78E-05 0
R/L 29673 Fn3-104 41 rs200639218 0.7689 -1.17 1.0 N 0.76 0.544 0.605592448911 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/L 29673 Fn3-104 41 rs200639218 0.7689 -1.17 1.0 N 0.76 0.544 0.605592448911 gnomAD-4.0.0 6.19677E-06 None None None None N None 1.3349E-05 1.66678E-05 None 0 0 None 0 0 6.78073E-06 0 0
R/Q 29673 Fn3-104 41 rs200639218 0.2547 -1.499 1.0 N 0.676 0.382 None gnomAD-2.1.1 2.14378E-04 None None None None N None 0 8.20089E-04 None 9.68E-05 5.12E-05 None 2.61438E-04 None 0 1.48747E-04 2.81136E-04
R/Q 29673 Fn3-104 41 rs200639218 0.2547 -1.499 1.0 N 0.676 0.382 None gnomAD-3.1.2 2.10308E-04 None None None None N None 0 1.5713E-03 0 0 0 None 0 0 1.02902E-04 0 4.78927E-04
R/Q 29673 Fn3-104 41 rs200639218 0.2547 -1.499 1.0 N 0.676 0.382 None gnomAD-4.0.0 1.43146E-04 None None None None N None 0 9.33396E-04 None 3.37861E-05 4.45633E-05 None 0 6.57678E-04 1.13577E-04 2.08599E-04 2.40161E-04
R/K 29774 Fn3-105 41 rs750672440 0.112 -1.432 None N 0.147 0.094 None gnomAD-2.1.1 3.19E-05 None None None None N None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
R/K 29774 Fn3-105 41 rs750672440 0.112 -1.432 None N 0.147 0.094 None gnomAD-3.1.2 3.29E-05 None None None None N None 1.20592E-04 0 0 0 0 None 0 0 0 0 0
R/K 29774 Fn3-105 41 rs750672440 0.112 -1.432 None N 0.147 0.094 None gnomAD-4.0.0 6.19669E-06 None None None None N None 1.20099E-04 0 None 0 0 None 0 0 8.4758E-07 0 0
R/K 29973 Fn3-106 41 rs1183482452 0.2496 -1.527 None N 0.15 0.111 0.21279746466 gnomAD-2.1.1 7.17E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 7.83E-06 0
R/K 29973 Fn3-106 41 rs1183482452 0.2496 -1.527 None N 0.15 0.111 0.21279746466 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/K 29973 Fn3-106 41 rs1183482452 0.2496 -1.527 None N 0.15 0.111 0.21279746466 gnomAD-4.0.0 1.86077E-06 None None None None N None 0 0 None 0 0 None 0 0 1.6952E-06 1.09794E-05 0
R/T 29973 Fn3-106 41 rs1183482452 0.9839 None 0.117 N 0.449 0.407 0.294918367191 gnomAD-4.0.0 2.73955E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.63747E-05 0
K/R 30070 Fn3-107 41 rs781508633 0.0747 -0.728 0.046 N 0.161 0.089 0.282575091529 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 1.30719E-04 None 0 0 0
K/R 30070 Fn3-107 41 rs781508633 0.0747 -0.728 0.046 N 0.161 0.089 0.282575091529 gnomAD-4.0.0 2.73667E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.47794E-05 1.6564E-05
R/G 30265 Fn3-108 42 None 0.9143 None 1.0 N 0.749 0.551 0.484329738948 gnomAD-4.0.0 1.3685E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31976E-05 0
R/Q 30265 Fn3-108 42 rs771164863 0.2942 -1.009 1.0 N 0.685 0.505 0.312608672186 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
R/Q 30265 Fn3-108 42 rs771164863 0.2942 -1.009 1.0 N 0.685 0.505 0.312608672186 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/Q 30265 Fn3-108 42 rs771164863 0.2942 -1.009 1.0 N 0.685 0.505 0.312608672186 gnomAD-4.0.0 9.91627E-06 None None None None N None 1.33554E-05 0 None 0 0 None 0 0 1.10196E-05 2.19717E-05 0
R/W 30265 Fn3-108 42 rs200022152 0.7372 -1.348 1.0 N 0.883 0.48 None gnomAD-2.1.1 9.29E-05 None None None None N None 2.06629E-04 2.83E-05 None 0 0 None 9.82E-05 None 1.20221E-04 1.01551E-04 1.40489E-04
R/W 30265 Fn3-108 42 rs200022152 0.7372 -1.348 1.0 N 0.883 0.48 None gnomAD-3.1.2 1.44665E-04 None None None None N None 2.89673E-04 0 0 0 0 None 2.82912E-04 0 7.35E-05 2.06868E-04 4.79386E-04
R/W 30265 Fn3-108 42 rs200022152 0.7372 -1.348 1.0 N 0.883 0.48 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
R/W 30265 Fn3-108 42 rs200022152 0.7372 -1.348 1.0 N 0.883 0.48 None gnomAD-4.0.0 8.11825E-05 None None None None N None 2.93279E-04 1.66728E-05 None 0 0 None 9.37734E-05 1.65071E-04 7.54412E-05 8.78677E-05 6.40225E-05
K/N 30364 Fn3-109 41 rs1395941923 0.9922 -1.822 1.0 N 0.742 0.434 0.243972157842 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
K/N 30364 Fn3-109 41 rs1395941923 0.9922 -1.822 1.0 N 0.742 0.434 0.243972157842 gnomAD-4.0.0 4.10514E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39667E-06 0 0
R/Q 30462 Fn3-110 41 rs794729529 0.2774 -1.001 1.0 N 0.69 0.444 0.28058544554 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 2.67E-05 0
R/Q 30462 Fn3-110 41 rs794729529 0.2774 -1.001 1.0 N 0.69 0.444 0.28058544554 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 2.07125E-04 0
R/Q 30462 Fn3-110 41 rs794729529 0.2774 -1.001 1.0 N 0.69 0.444 0.28058544554 gnomAD-4.0.0 2.85122E-05 None None None None N None 0 0 None 0 2.23204E-05 None 1.56294E-05 0 3.39085E-05 2.19597E-05 3.20287E-05
R/W 30462 Fn3-110 41 rs373623340 0.6015 -0.833 1.0 N 0.88 0.474 None gnomAD-2.1.1 5.36E-05 None None None None N None 4.54959E-04 2.83E-05 None 0 0 None 3.27E-05 None 0 1.57E-05 0
R/W 30462 Fn3-110 41 rs373623340 0.6015 -0.833 1.0 N 0.88 0.474 None gnomAD-3.1.2 1.0523E-04 None None None None N None 3.62301E-04 0 0 0 0 None 0 0 1.47E-05 0 0
R/W 30462 Fn3-110 41 rs373623340 0.6015 -0.833 1.0 N 0.88 0.474 None 1000 genomes 5.99042E-04 None None None None N None 2.3E-03 0 None None 0 0 None None None 0 None
R/W 30462 Fn3-110 41 rs373623340 0.6015 -0.833 1.0 N 0.88 0.474 None gnomAD-4.0.0 2.29324E-05 None None None None N None 3.33431E-04 1.66733E-05 None 0 0 None 0 3.30142E-04 1.69542E-06 1.09815E-05 9.60523E-05
R/Q 30660 Fn3-111 42 rs765986284 0.5938 -1.055 1.0 N 0.695 0.486 0.260735089382 gnomAD-2.1.1 2.41E-05 None None None None N None 6.46E-05 5.8E-05 None 0 0 None 0 None 0 2.66E-05 0
R/Q 30660 Fn3-111 42 rs765986284 0.5938 -1.055 1.0 N 0.695 0.486 0.260735089382 gnomAD-4.0.0 1.16322E-05 None None None None N None 2.98846E-05 8.94574E-05 None 0 0 None 0 0 9.89458E-06 1.1595E-05 0
R/W 30660 Fn3-111 42 rs377464325 0.9246 -1.009 1.0 N 0.882 0.502 None gnomAD-2.1.1 1.78E-05 None None None None N None 1.24018E-04 2.83E-05 None 0 0 None 0 None 0 0 1.40371E-04
R/W 30660 Fn3-111 42 rs377464325 0.9246 -1.009 1.0 N 0.882 0.502 None gnomAD-3.1.2 2.63E-05 None None None None N None 9.66E-05 0 0 0 0 None 0 0 0 0 0
R/W 30660 Fn3-111 42 rs377464325 0.9246 -1.009 1.0 N 0.882 0.502 None gnomAD-4.0.0 1.17752E-05 None None None None N None 1.3354E-04 6.67E-05 None 0 2.22926E-05 None 0 0 1.69528E-06 1.09815E-05 1.60123E-05
R/K 30759 Fn3-112 41 rs769687279 0.2994 -1.133 0.997 N 0.46 0.33 0.418344901717 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
R/K 30759 Fn3-112 41 rs769687279 0.2994 -1.133 0.997 N 0.46 0.33 0.418344901717 gnomAD-4.0.0 1.59115E-06 None None None None N None 0 0 None 0 2.773E-05 None 0 0 0 0 0
C/F 30861 Fn3-113 41 None 0.4502 None 0.949 N 0.74 0.335 0.705029066125 gnomAD-4.0.0 1.36836E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79886E-06 0 0
C/R 30861 Fn3-113 41 rs2154147860 0.2643 None 0.901 N 0.791 0.444 0.64097366104 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
C/Y 30861 Fn3-113 41 rs1045877862 0.4743 -1.623 0.983 N 0.745 0.344 0.735756410601 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
C/Y 30861 Fn3-113 41 rs1045877862 0.4743 -1.623 0.983 N 0.745 0.344 0.735756410601 gnomAD-4.0.0 3.42089E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49716E-06 0 0
R/L 31056 Fn3-114 41 None 0.945 None 1.0 N 0.784 0.45 0.667105625577 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92753E-04 None 0 0 0 0 0
R/L 31056 Fn3-114 41 None 0.945 None 1.0 N 0.784 0.45 0.667105625577 gnomAD-4.0.0 6.56668E-06 None None None None N None 0 0 None 0 1.93199E-04 None 0 0 0 0 0
R/Q 31056 Fn3-114 41 rs201377736 0.548 -1.044 1.0 N 0.685 0.384 0.231873229951 gnomAD-3.1.2 1.97E-05 None None None None N None 0 1.96335E-04 0 0 0 None 0 0 0 0 0
R/Q 31056 Fn3-114 41 rs201377736 0.548 -1.044 1.0 N 0.685 0.384 0.231873229951 gnomAD-4.0.0 8.67471E-06 None None None None N None 3.99808E-05 4.99817E-05 None 0 0 None 0 0 5.93318E-06 0 1.60041E-05
R/G 31153 Fn3-115 41 None 0.7236 None 0.896 N 0.601 0.383 0.465721554213 gnomAD-4.0.0 6.8417E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99439E-07 0 0
R/K 31153 Fn3-115 41 None 0.1057 None 0.011 N 0.115 0.124 0.252162846088 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
R/C 31349 Fn3-116 42 rs727503549 0.521 -2.001 1.0 N 0.845 0.499 0.65667953858 gnomAD-2.1.1 8.93E-05 None None None None N None 0 0 None 3.87222E-04 1.02617E-04 None 4.24809E-04 None 1.19894E-04 7.82E-06 2.80899E-04
R/C 31349 Fn3-116 42 rs727503549 0.521 -2.001 1.0 N 0.845 0.499 0.65667953858 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 9.43E-05 0 1.47E-05 2.07383E-04 4.78011E-04
R/C 31349 Fn3-116 42 rs727503549 0.521 -2.001 1.0 N 0.845 0.499 0.65667953858 gnomAD-4.0.0 5.32947E-05 None None None None N None 0 0 None 3.71622E-04 2.89842E-04 None 7.81128E-05 0 1.61042E-05 3.73298E-04 6.4043E-05
R/G 31349 Fn3-116 42 rs727503549 0.9426 -2.66 1.0 N 0.779 0.559 0.629010756219 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
R/H 31349 Fn3-116 42 rs181104321 0.5146 -2.395 1.0 N 0.715 0.405 None gnomAD-2.1.1 2.22519E-03 None None None None N None 2.76951E-03 7.36002E-04 None 0 0 None 3.27E-05 None 1.41487E-02 1.22756E-03 2.5288E-03
R/H 31349 Fn3-116 42 rs181104321 0.5146 -2.395 1.0 N 0.715 0.405 None gnomAD-3.1.2 2.64279E-03 None None None None N None 2.99329E-03 1.57377E-03 0 0 0 None 1.51658E-02 0 1.30836E-03 2.07039E-04 1.43403E-03
R/H 31349 Fn3-116 42 rs181104321 0.5146 -2.395 1.0 N 0.715 0.405 None 1000 genomes 1.19808E-03 None None None None N None 8E-04 1.4E-03 None None 0 4E-03 None None None 0 None
R/H 31349 Fn3-116 42 rs181104321 0.5146 -2.395 1.0 N 0.715 0.405 None gnomAD-4.0.0 1.71084E-03 None None None None N None 2.81243E-03 9.66925E-04 None 0 0 None 1.32006E-02 3.29924E-04 1.32223E-03 1.09789E-04 1.20035E-03
R/L 31349 Fn3-116 42 rs181104321 0.8767 -1.325 1.0 N 0.779 0.475 0.565757058302 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
K/N 31448 Fn3-117 41 rs1475927387 0.9982 None 1.0 N 0.735 0.434 0.268211541103 gnomAD-4.0.0 1.36839E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79893E-06 0 0
K/Q 31546 Fn3-118 41 rs746533506 0.3448 -1.853 1.0 N 0.71 0.411 0.257786959452 gnomAD-2.1.1 8.06E-06 None None None None N None 1.29299E-04 0 None 0 0 None 0 None 0 0 0
R/C 31748 Fn3-119 41 rs142525903 0.6683 -1.626 1.0 N 0.903 0.496 None gnomAD-2.1.1 9.89512E-04 None None None None N None 1.23987E-03 4.24713E-04 None 1.69344E-02 0 None 3.27E-05 None 0 3.20628E-04 2.10615E-03
R/C 31748 Fn3-119 41 rs142525903 0.6683 -1.626 1.0 N 0.903 0.496 None gnomAD-3.1.2 7.42688E-04 None None None None N None 8.68768E-04 2.61849E-04 0 1.49942E-02 0 None 0 0 2.2053E-04 0 2.87356E-03
R/C 31748 Fn3-119 41 rs142525903 0.6683 -1.626 1.0 N 0.903 0.496 None 1000 genomes 1.19808E-03 None None None None N None 4.5E-03 0 None None 0 0 None None None 0 None
R/C 31748 Fn3-119 41 rs142525903 0.6683 -1.626 1.0 N 0.903 0.496 None gnomAD-4.0.0 5.91154E-04 None None None None N None 1.23964E-03 3.99933E-04 None 1.67917E-02 0 None 0 3.63036E-03 1.72066E-04 1.09791E-05 1.8247E-03
R/H 31748 Fn3-119 41 rs547575746 0.7752 -2.626 1.0 N 0.762 0.678 0.403469152278 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
R/H 31748 Fn3-119 41 rs547575746 0.7752 -2.626 1.0 N 0.762 0.678 0.403469152278 1000 genomes None None None None None N None 0 0 None None 0 0 None None None 0 None
R/H 31748 Fn3-119 41 rs547575746 0.7752 -2.626 1.0 N 0.762 0.678 0.403469152278 gnomAD-4.0.0 1.84739E-05 None None None None N None 0 0 None 0 2.52054E-05 None 0 0 1.8889E-05 3.47802E-05 3.31334E-05
R/L 31748 Fn3-119 41 None 0.9406 None 1.0 N 0.779 0.68 0.602559457607 gnomAD-4.0.0 6.84219E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99475E-07 0 0
R/S 31748 Fn3-119 41 rs142525903 0.9928 -1.926 1.0 N 0.773 0.559 0.403328974453 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/S 31748 Fn3-119 41 rs142525903 0.9928 -1.926 1.0 N 0.773 0.559 0.403328974453 gnomAD-4.0.0 6.84216E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
R/C 31847 Fn3-120 41 rs774814532 0.5596 -1.7 1.0 N 0.919 0.535 0.437850553699 gnomAD-2.1.1 2.41E-05 None None None None N None 0 2.9E-05 None 0 2.22568E-04 None 0 None 0 8.87E-06 0
R/C 31847 Fn3-120 41 rs774814532 0.5596 -1.7 1.0 N 0.919 0.535 0.437850553699 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92827E-04 None 0 0 0 0 0
R/C 31847 Fn3-120 41 rs774814532 0.5596 -1.7 1.0 N 0.919 0.535 0.437850553699 gnomAD-4.0.0 1.36341E-05 None None None None N None 0 1.66706E-05 None 0 1.78245E-04 None 0 3.29056E-04 9.3242E-06 0 0
R/H 31847 Fn3-120 41 rs771179752 0.3992 -2.762 1.0 N 0.765 0.644 None gnomAD-2.1.1 4.02E-05 None None None None N None 0 0 None 0 1.11272E-04 None 3.27E-05 None 1.39237E-04 3.55E-05 0
R/H 31847 Fn3-120 41 rs771179752 0.3992 -2.762 1.0 N 0.765 0.644 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/H 31847 Fn3-120 41 rs771179752 0.3992 -2.762 1.0 N 0.765 0.644 None gnomAD-4.0.0 4.46199E-05 None None None None N None 0 1.66694E-05 None 0 3.11929E-04 None 7.80933E-05 6.58111E-04 3.8992E-05 2.19587E-05 0
R/P 31847 Fn3-120 41 rs771179752 0.999 None 1.0 D 0.873 0.749 0.565354849907 Rees (2021) None MmD comp het with R5430* None None N Genetic analysis of TTN in 30 CM patients; comp het with truncating; Domain unfolded in vitro; cannot be re-folded None None None None None None None None None None None
R/P 31847 Fn3-120 41 rs771179752 0.999 None 1.0 D 0.873 0.749 0.565354849907 gnomAD-4.0.0 6.84237E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99523E-07 0 0
R/C 32145 Fn3-122 41 rs878907981 0.8258 -1.616 1.0 N 0.886 0.498 None gnomAD-2.1.1 3.19E-05 None None None None N None 1.14837E-04 0 None 0 0 None 0 None 0 0 0
R/C 32145 Fn3-122 41 rs878907981 0.8258 -1.616 1.0 N 0.886 0.498 None gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
R/C 32145 Fn3-122 41 rs878907981 0.8258 -1.616 1.0 N 0.886 0.498 None gnomAD-4.0.0 5.58189E-06 None None None None N None 4.00481E-05 0 None 0 0 None 0 0 4.23839E-06 1.09815E-05 0
R/H 32145 Fn3-122 41 rs759948951 0.7837 -2.274 1.0 N 0.761 0.553 0.38225645794 gnomAD-2.1.1 1.62E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 1.66778E-04
R/H 32145 Fn3-122 41 rs759948951 0.7837 -2.274 1.0 N 0.761 0.553 0.38225645794 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
R/H 32145 Fn3-122 41 rs759948951 0.7837 -2.274 1.0 N 0.761 0.553 0.38225645794 gnomAD-4.0.0 1.30229E-05 None None None None N None 0 0 None 0 2.23135E-05 None 0 0 1.52582E-05 1.09827E-05 1.60133E-05
C/Y 32242 Fn3-123 41 None 0.4298 None 0.995 N 0.751 0.4 0.750831387573 gnomAD-4.0.0 8.40225E-06 None None None None N None 0 0 None 0 0 None 0 0 9.18751E-06 0 0
R/C 32440 Fn3-124 42 rs759932470 0.706 -1.674 1.0 N 0.891 0.559 0.609718080597 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/C 32440 Fn3-124 42 rs759932470 0.706 -1.674 1.0 N 0.891 0.559 0.609718080597 gnomAD-4.0.0 3.42133E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69855E-06 1.15939E-05 1.65667E-05
R/H 32440 Fn3-124 42 rs750047570 0.7765 -2.253 1.0 N 0.755 0.559 0.46512379133 gnomAD-2.1.1 7.15E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.57E-05 0
R/H 32440 Fn3-124 42 rs750047570 0.7765 -2.253 1.0 N 0.755 0.559 0.46512379133 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
R/H 32440 Fn3-124 42 rs750047570 0.7765 -2.253 1.0 N 0.755 0.559 0.46512379133 gnomAD-4.0.0 9.91604E-06 None None None None N None 6.67539E-05 1.66717E-05 None 0 0 None 0 0 8.47659E-06 0 0
R/Q 32836 Fn3-127 42 rs368312810 0.3077 -1.034 1.0 N 0.679 0.409 None gnomAD-2.1.1 8.04E-06 None None None None N None 6.46E-05 0 None 0 0 None 3.27E-05 None 0 0 0
R/Q 32836 Fn3-127 42 rs368312810 0.3077 -1.034 1.0 N 0.679 0.409 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
R/Q 32836 Fn3-127 42 rs368312810 0.3077 -1.034 1.0 N 0.679 0.409 None gnomAD-4.0.0 1.11546E-05 None None None None N None 2.67108E-05 0 None 0 2.22816E-05 None 0 1.64474E-04 1.01712E-05 2.19558E-05 0
K/E 32937 Fn3-128 42 rs200544701 0.8538 -0.841 0.722 N 0.512 0.167 None gnomAD-2.1.1 1.96287E-04 None None None None N None 0 5.09251E-04 None 2.90135E-03 0 None 6.54E-05 None 0 1.56E-05 4.20994E-04
K/E 32937 Fn3-128 42 rs200544701 0.8538 -0.841 0.722 N 0.512 0.167 None gnomAD-3.1.2 1.05169E-04 None None None None N None 0 2.62089E-04 0 2.59366E-03 0 None 0 0 4.41E-05 0 0
K/E 32937 Fn3-128 42 rs200544701 0.8538 -0.841 0.722 N 0.512 0.167 None gnomAD-4.0.0 9.17171E-05 None None None None N None 1.33501E-05 4.66838E-04 None 2.80424E-03 0 None 0 0 2.11908E-05 2.19573E-05 1.44106E-04
R/I 33038 Fn3-129 41 None 0.9841 None 1.0 N 0.885 0.537 0.842324735218 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
C/R 33331 Fn3-130 42 rs56061641 0.0914 -0.874 0.001 N 0.44 0.241 None gnomAD-2.1.1 2.61592E-04 None None None None N None 2.90505E-04 6.53595E-04 None 0 0 None 3.61319E-04 None 0 2.03816E-04 8.44832E-04
C/R 33331 Fn3-130 42 rs56061641 0.0914 -0.874 0.001 N 0.44 0.241 None gnomAD-3.1.2 2.95885E-04 None None None None N None 9.66E-05 1.1794E-03 0 0 0 None 0 1.58228E-02 1.91137E-04 2.07297E-04 1.91571E-03
C/R 33331 Fn3-130 42 rs56061641 0.0914 -0.874 0.001 N 0.44 0.241 None 1000 genomes 1.39776E-03 None None None None N None 5.3E-03 0 None None 0 0 None None None 0 None
C/R 33331 Fn3-130 42 rs56061641 0.0914 -0.874 0.001 N 0.44 0.241 None gnomAD-4.0.0 2.12603E-04 None None None None N None 2.5336E-04 7.3419E-04 None 0 0 None 0 1.35269E-02 1.17835E-04 3.62613E-04 4.1632E-04
C/S 33331 Fn3-130 42 rs56061641 0.4716 None 0.425 N 0.511 0.199 0.511790803624 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
C/S 33331 Fn3-130 42 rs56061641 0.4716 None 0.425 N 0.511 0.199 0.511790803624 gnomAD-4.0.0 2.47952E-06 None None None None N None 0 0 None 0 0 None 0 0 3.3909E-06 0 0
R/C 33432 Fn3-131 41 rs878882035 0.3593 None 1.0 D 0.87 0.431 0.630346058385 gnomAD-4.0.0 3.20381E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87778E-06 1.4445E-05 0
R/G 33432 Fn3-131 41 None 0.8767 None 1.0 N 0.798 0.526 0.636843794314 gnomAD-4.0.0 1.60191E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4445E-05 0
R/H 33432 Fn3-131 41 rs374876608 0.3864 -2.17 1.0 N 0.742 0.437 None gnomAD-2.1.1 5.76E-05 None None None None N None 0 0 None 0 1.53941E-04 None 2.98567E-04 None 0 2.37E-05 1.41884E-04
R/H 33432 Fn3-131 41 rs374876608 0.3864 -2.17 1.0 N 0.742 0.437 None gnomAD-3.1.2 1.70814E-04 None None None None N None 0 0 2.30263E-02 0 0 None 0 0 7.35E-05 0 0
R/H 33432 Fn3-131 41 rs374876608 0.3864 -2.17 1.0 N 0.742 0.437 None gnomAD-4.0.0 5.65062E-05 None None None None N None 2.67544E-05 3.34672E-05 None 0 6.68598E-05 None 0 1.64853E-04 3.14121E-05 2.64696E-04 1.60503E-05
C/Y 33729 Fn3-132 41 None 0.709 None 0.999 N 0.707 0.403 0.704489790954 gnomAD-4.0.0 1.59115E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85794E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.