Structural position:

  • Domain Type: Fn3
  • Aligned Position: 44
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand C

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
D/H 15698 Fn3-1 42 None 0.987 None 1.0 D 0.755 0.494 0.440810947182 gnomAD-4.0.0 6.84683E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9991E-07 0 0
D/N 15698 Fn3-1 42 rs1045612706 0.8465 -1.39 1.0 D 0.657 0.421 0.465633601861 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/N 15698 Fn3-1 42 rs1045612706 0.8465 -1.39 1.0 D 0.657 0.421 0.465633601861 gnomAD-4.0.0 8.2162E-06 None None None None N None 0 0 None 0 0 None 0 0 9.89901E-06 1.15966E-05 0
D/V 15698 Fn3-1 42 None 0.9821 None 1.0 D 0.817 0.57 0.534287799004 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
D/E 15799 Fn3-2 42 rs762148576 0.253 -0.494 0.014 N 0.221 0.09 0.33110744837 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
D/E 15799 Fn3-2 42 rs762148576 0.253 -0.494 0.014 N 0.221 0.09 0.33110744837 gnomAD-4.0.0 1.59341E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86275E-06 0 0
D/N 15799 Fn3-2 42 rs1364793607 0.1209 -0.761 0.032 N 0.197 0.219 0.325533332567 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
D/N 15799 Fn3-2 42 rs1364793607 0.1209 -0.761 0.032 N 0.197 0.219 0.325533332567 gnomAD-4.0.0 6.58475E-06 None None None None N None 2.41511E-05 0 None 0 0 None 0 0 0 0 0
E/A 15900 Fn3-3 42 None 0.1649 None 0.999 N 0.661 0.48 0.493494165309 gnomAD-4.0.0 1.65614E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.56304E-05 0
E/K 15900 Fn3-3 42 rs772625773 0.1208 -0.829 1.0 N 0.577 0.428 0.442363741745 gnomAD-2.1.1 3.68E-05 None None None None N None 7.24E-05 0 None 0 0 None 8.18E-05 None 0 5.04E-05 0
E/K 15900 Fn3-3 42 rs772625773 0.1208 -0.829 1.0 N 0.577 0.428 0.442363741745 gnomAD-4.0.0 1.94871E-05 None None None None N None 3.0954E-05 0 None 0 2.55872E-05 None 0 0 2.0862E-05 2.48614E-05 1.68327E-05
P/L 16196 Fn3-5 42 rs1485291993 0.0918 None 0.001 N 0.292 0.266 0.441740949975 gnomAD-4.0.0 2.73891E-06 None None None None N None 0 0 None 0 0 None 0 0 3.6E-06 0 0
P/S 16196 Fn3-5 42 None 0.1264 None 0.183 N 0.356 0.257 0.17258766438 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
A/E 16392 Fn3-6 42 rs750310775 0.3218 -2.29 1.0 N 0.787 0.306 None gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
A/E 16392 Fn3-6 42 rs750310775 0.3218 -2.29 1.0 N 0.787 0.306 None gnomAD-4.0.0 1.30084E-05 None None None None N None 0 0 None 0 0 None 0 0 1.61963E-05 0 1.65843E-05
A/T 16392 Fn3-6 42 rs794729446 0.1329 None 1.0 N 0.699 0.288 0.325533332567 gnomAD-4.0.0 1.59368E-06 None None None None N None 5.67151E-05 0 None 0 0 None 0 0 0 0 0
D/G 16491 Fn3-7 42 rs1464618103 0.8559 -1.318 0.989 N 0.531 0.418 0.326616659874 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
D/N 16491 Fn3-7 42 None 0.3742 None 0.989 N 0.485 0.294 0.365703291355 gnomAD-4.0.0 6.84644E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16025E-05 0
D/Y 16491 Fn3-7 42 None 0.5446 None 1.0 D 0.742 0.358 0.580379909603 gnomAD-4.0.0 6.84644E-07 None None None None N None 2.99365E-05 0 None 0 0 None 0 0 0 0 0
K/R 16592 Fn3-8 42 rs1017317726 0.16 -0.234 0.999 N 0.563 0.332 0.227934060464 gnomAD-2.1.1 4.03E-05 None None None None N None 0 2.90461E-04 None 0 0 None 0 None 0 0 0
K/R 16592 Fn3-8 42 rs1017317726 0.16 -0.234 0.999 N 0.563 0.332 0.227934060464 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
K/R 16592 Fn3-8 42 rs1017317726 0.16 -0.234 0.999 N 0.563 0.332 0.227934060464 gnomAD-4.0.0 1.41114E-05 None None None None N None 0 1.86687E-04 None 0 0 None 0 0 0 0 0
P/A 16893 Fn3-11 42 None 0.0837 None 0.051 N 0.203 0.186 0.16115917748 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
E/G 17088 Fn3-12 42 None 0.9555 None 1.0 N 0.715 0.545 0.486422812247 gnomAD-4.0.0 6.84497E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99811E-07 0 0
E/Q 17088 Fn3-12 42 None 0.9072 None 1.0 N 0.628 0.347 0.478144874143 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/S 17188 Fn3-13 42 rs1324072715 0.1016 -1.201 0.012 N 0.379 0.053 0.156986980423 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
A/S 17188 Fn3-13 42 rs1324072715 0.1016 -1.201 0.012 N 0.379 0.053 0.156986980423 gnomAD-4.0.0 1.59263E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43336E-05 0
A/T 17188 Fn3-13 42 None 0.1139 None None N 0.255 0.053 0.162503812791 gnomAD-4.0.0 1.59263E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86149E-06 0 0
D/G 17410 Fn3-14 42 rs757885544 0.9251 -1.222 0.006 N 0.355 0.276 0.246773566709 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
D/G 17410 Fn3-14 42 rs757885544 0.9251 -1.222 0.006 N 0.355 0.276 0.246773566709 gnomAD-4.0.0 4.78126E-06 None None None None N None 0 0 None 0 0 None 0 0 8.586E-06 0 0
D/H 17410 Fn3-14 42 None 0.9381 None 0.98 N 0.739 0.456 0.429320821379 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
D/V 17410 Fn3-14 42 rs757885544 0.8326 0.287 0.864 N 0.766 0.384 0.62097610211 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14732E-04 0 None 0 0 None 0 None 0 0 0
D/V 17410 Fn3-14 42 rs757885544 0.8326 0.287 0.864 N 0.766 0.384 0.62097610211 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/V 17410 Fn3-14 42 rs757885544 0.8326 0.287 0.864 N 0.766 0.384 0.62097610211 gnomAD-4.0.0 6.5786E-06 None None None None N None 2.41278E-05 0 None 0 0 None 0 0 0 0 0
E/D 17510 Fn3-15 41 None 0.7595 None 0.999 N 0.441 0.278 0.344251166708 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
E/K 17510 Fn3-15 41 rs754803968 0.9608 -1.265 0.999 N 0.559 0.367 0.377976839388 gnomAD-2.1.1 8.12E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.8E-05 0
E/K 17510 Fn3-15 41 rs754803968 0.9608 -1.265 0.999 N 0.559 0.367 0.377976839388 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 17510 Fn3-15 41 rs754803968 0.9608 -1.265 0.999 N 0.559 0.367 0.377976839388 gnomAD-4.0.0 3.85166E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19114E-06 0 0
D/Y 17805 Fn3-17 42 rs1051218836 0.9603 -0.056 0.999 N 0.813 0.427 0.75224819921 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/Y 17805 Fn3-17 42 rs1051218836 0.9603 -0.056 0.999 N 0.813 0.427 0.75224819921 gnomAD-4.0.0 2.05351E-06 None None None None N None 0 0 None 0 0 None 0 1.73671E-04 0 0 3.31554E-05
R/C 17903 Fn3-18 42 rs1016726284 0.1751 -0.993 1.0 N 0.703 0.359 0.568250393081 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 1.78E-05 0
R/C 17903 Fn3-18 42 rs1016726284 0.1751 -0.993 1.0 N 0.703 0.359 0.568250393081 gnomAD-3.1.2 1.98E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 17903 Fn3-18 42 rs1016726284 0.1751 -0.993 1.0 N 0.703 0.359 0.568250393081 gnomAD-4.0.0 9.92555E-06 None None None None N None 2.67566E-05 0 None 0 4.46887E-05 None 0 0 5.93851E-06 3.29815E-05 3.20657E-05
R/G 17903 Fn3-18 42 rs1016726284 0.5072 None 0.036 N 0.321 0.179 0.386395597597 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07555E-04 0
R/G 17903 Fn3-18 42 rs1016726284 0.5072 None 0.036 N 0.321 0.179 0.386395597597 gnomAD-4.0.0 6.58657E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07555E-04 0
R/H 17903 Fn3-18 42 rs755252821 0.1897 -1.978 0.998 N 0.561 0.321 None gnomAD-2.1.1 7.15E-06 None None None None N None 4.14E-05 0 None 0 0 None 0 None 0 7.84E-06 0
R/H 17903 Fn3-18 42 rs755252821 0.1897 -1.978 0.998 N 0.561 0.321 None gnomAD-3.1.2 6.6E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/H 17903 Fn3-18 42 rs755252821 0.1897 -1.978 0.998 N 0.561 0.321 None gnomAD-4.0.0 1.67614E-05 None None None None N None 1.33758E-05 1.67023E-05 None 0 0 None 0 0 1.95221E-05 2.20124E-05 0
E/K 18207 Fn3-20 42 None 0.5865 None 0.016 N 0.237 0.26 0.31291088546 gnomAD-4.0.0 1.59316E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02755E-05
E/D 18313 Fn3-21 42 rs751397444 0.1922 -1.152 0.004 N 0.129 0.01 0.124217242631 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
T/A 18520 Fn3-22 42 None 0.1084 None 0.01 N 0.08 0.112 0.170165803431 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 7.32654E-05
T/I 18520 Fn3-22 42 None 0.3772 None 0.784 N 0.468 0.219 0.327419511103 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/G 18620 Fn3-23 42 rs549301447 0.1433 -1.577 0.081 N 0.343 0.096 0.101711395817 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 8.94E-06 0
A/G 18620 Fn3-23 42 rs549301447 0.1433 -1.577 0.081 N 0.343 0.096 0.101711395817 gnomAD-4.0.0 3.42264E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69933E-06 0 3.31433E-05
A/V 18620 Fn3-23 42 rs549301447 0.1103 -0.171 0.001 N 0.209 0.103 0.177238962908 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
A/V 18620 Fn3-23 42 rs549301447 0.1103 -0.171 0.001 N 0.209 0.103 0.177238962908 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
A/V 18620 Fn3-23 42 rs549301447 0.1103 -0.171 0.001 N 0.209 0.103 0.177238962908 gnomAD-4.0.0 1.85999E-06 None None None None N None 0 1.66839E-05 None 0 0 None 0 0 0 2.19766E-05 0
E/K 19029 Fn3-26 42 None 0.2064 None 0.698 N 0.438 0.244 0.251639045875 gnomAD-4.0.0 1.37312E-06 None None None None N None 0 0 None 0 0 None 0 0 9.00409E-07 1.18223E-05 0
E/Q 19029 Fn3-26 42 rs761979702 0.1796 -0.785 0.294 N 0.227 0.116 0.195762928549 gnomAD-2.1.1 1.64E-05 None None None None N None 0 0 None 0 2.29043E-04 None 0 None 0 0 0
E/Q 19029 Fn3-26 42 rs761979702 0.1796 -0.785 0.294 N 0.227 0.116 0.195762928549 gnomAD-4.0.0 1.51043E-05 None None None None N None 0 0 None 0 5.5747E-04 None 0 0 0 0 0
E/K 19225 Fn3-27 43 rs2051373830 0.6528 None 0.994 N 0.562 0.401 0.486209434461 gnomAD-4.0.0 3.20906E-06 None None None None N None 0 2.3175E-05 None 0 0 None 0 0 0 1.46066E-05 0
E/D 19521 Fn3-29 43 rs1156295835 0.179 -1.244 0.001 N 0.083 0.039 0.0611884634855 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 9.97E-05 0 None 0 None 0 8.91E-06 0
E/D 19521 Fn3-29 43 rs1156295835 0.179 -1.244 0.001 N 0.083 0.039 0.0611884634855 gnomAD-4.0.0 3.18433E-06 None None None None N None 0 0 None 4.77008E-05 0 None 0 0 2.8593E-06 0 0
E/G 19521 Fn3-29 43 rs543122164 0.5183 -1.112 0.549 N 0.456 0.32 0.482209950775 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.61E-05 None 0 None 0 0 0
E/G 19521 Fn3-29 43 rs543122164 0.5183 -1.112 0.549 N 0.456 0.32 0.482209950775 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94175E-04 None 0 0 0 0 0
E/G 19521 Fn3-29 43 rs543122164 0.5183 -1.112 0.549 N 0.456 0.32 0.482209950775 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
E/G 19521 Fn3-29 43 rs543122164 0.5183 -1.112 0.549 N 0.456 0.32 0.482209950775 gnomAD-4.0.0 2.56333E-06 None None None None N None 0 0 None 0 4.86997E-05 None 0 0 0 0 0
E/K 19521 Fn3-29 43 rs746319976 0.7126 -0.338 0.549 N 0.381 0.223 0.394384168047 gnomAD-2.1.1 2.02E-05 None None None None N None 0 1.45214E-04 None 0 0 None 0 None 0 0 0
E/K 19521 Fn3-29 43 rs746319976 0.7126 -0.338 0.549 N 0.381 0.223 0.394384168047 gnomAD-3.1.2 1.32E-05 None None None None N None 0 1.31113E-04 0 0 0 None 0 0 0 0 0
E/K 19521 Fn3-29 43 rs746319976 0.7126 -0.338 0.549 N 0.381 0.223 0.394384168047 gnomAD-4.0.0 5.579E-06 None None None None N None 0 1.5017E-04 None 0 0 None 0 0 0 0 0
E/V 19521 Fn3-29 43 rs543122164 0.4538 0.553 0.896 N 0.457 0.388 0.640367608718 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
E/D 19619 Fn3-30 41 rs368026488 0.6559 -1.048 0.999 N 0.443 0.125 0.412980791724 gnomAD-2.1.1 4.28E-05 None None None None N None 4.96073E-04 0 None 0 0 None 0 None 0 0 0
E/D 19619 Fn3-30 41 rs368026488 0.6559 -1.048 0.999 N 0.443 0.125 0.412980791724 gnomAD-3.1.2 8.55E-05 None None None None N None 3.13691E-04 0 0 0 0 None 0 0 0 0 0
E/D 19619 Fn3-30 41 rs368026488 0.6559 -1.048 0.999 N 0.443 0.125 0.412980791724 gnomAD-4.0.0 1.3637E-05 None None None None N None 2.93764E-04 0 None 0 0 None 0 0 0 0 0
E/Q 19619 Fn3-30 41 rs2050656359 0.8283 None 1.0 N 0.599 0.38 0.452168903601 gnomAD-4.0.0 1.44039E-05 None None None None N None 0 0 None 0 0 None 0 0 1.575E-05 0 0
D/N 20213 Fn3-34 43 rs1186567480 0.2679 -1.206 0.549 N 0.423 0.252 0.277317399466 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/N 20213 Fn3-34 43 rs1186567480 0.2679 -1.206 0.549 N 0.423 0.252 0.277317399466 gnomAD-4.0.0 1.59217E-06 None None None None N None 0 2.28812E-05 None 0 0 None 0 0 0 0 0
E/D 20312 Fn3-35 42 rs1337998707 0.2887 -0.76 0.954 N 0.492 0.194 0.240491677333 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14705E-04 0 None 0 0 None 0 None 0 0 0
E/D 20312 Fn3-35 42 rs1337998707 0.2887 -0.76 0.954 N 0.492 0.194 0.240491677333 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/D 20312 Fn3-35 42 rs1337998707 0.2887 -0.76 0.954 N 0.492 0.194 0.240491677333 gnomAD-4.0.0 6.57514E-06 None None None None N None 2.4122E-05 0 None 0 0 None 0 0 0 0 0
E/K 20312 Fn3-35 42 rs759127797 0.6645 -0.064 0.961 N 0.529 0.31 None gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/K 20312 Fn3-35 42 rs759127797 0.6645 -0.064 0.961 N 0.529 0.31 None gnomAD-4.0.0 4.35545E-06 None None None None N None 2.67423E-05 0 None 0 0 None 0 0 4.25599E-06 0 0
K/Q 20412 Fn3-36 42 rs1465889294 0.153 -0.493 0.999 N 0.604 0.349 0.241664281697 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/Q 20412 Fn3-36 42 rs1465889294 0.153 -0.493 0.999 N 0.604 0.349 0.241664281697 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
K/Q 20412 Fn3-36 42 rs1465889294 0.153 -0.493 0.999 N 0.604 0.349 0.241664281697 gnomAD-4.0.0 2.5642E-06 None None None None N None 0 3.39248E-05 None 0 0 None 0 0 0 0 0
L/F 20709 Fn3-38 42 rs371705537 0.2063 -1.113 0.996 N 0.391 0.161 None gnomAD-2.1.1 4.04E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
L/F 20709 Fn3-38 42 rs371705537 0.2063 -1.113 0.996 N 0.391 0.161 None gnomAD-3.1.2 3.95E-05 None None None None N None 1.4483E-04 0 0 0 0 None 0 0 0 0 0
L/F 20709 Fn3-38 42 rs371705537 0.2063 -1.113 0.996 N 0.391 0.161 None gnomAD-4.0.0 5.57906E-06 None None None None N None 1.06869E-04 0 None 0 0 None 0 0 0 0 1.60138E-05
E/G 21004 Fn3-40 42 None 0.6153 None 0.014 N 0.329 0.292 0.413113201963 gnomAD-4.0.0 1.59233E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85997E-06 0 0
E/K 21004 Fn3-40 42 rs769345390 0.8131 -0.8 0.822 N 0.499 0.338 0.444807159249 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
E/K 21004 Fn3-40 42 rs769345390 0.8131 -0.8 0.822 N 0.499 0.338 0.444807159249 gnomAD-4.0.0 1.59237E-06 None None None None N None 0 0 None 0 2.77994E-05 None 0 0 0 0 0
P/L 21105 Fn3-41 42 rs773378006 0.1373 -0.522 0.003 N 0.371 0.161 0.370608029945 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.62E-05 None 0 None 0 0 0
P/L 21105 Fn3-41 42 rs773378006 0.1373 -0.522 0.003 N 0.371 0.161 0.370608029945 gnomAD-4.0.0 4.77937E-06 None None None None N None 0 0 None 0 5.56917E-05 None 1.88288E-05 0 0 0 0
E/G 21407 Fn3-43 42 rs1413732448 0.4291 None 0.379 N 0.475 0.17 0.319402600006 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 21407 Fn3-43 42 rs1413732448 0.4291 None 0.379 N 0.475 0.17 0.319402600006 gnomAD-4.0.0 6.09034E-06 None None None None N None 0 0 None 0 0 None 0 0 7.22986E-06 0 0
E/G 21700 Fn3-45 42 rs2048488125 0.9068 None 1.0 N 0.673 0.561 0.611786747218 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 21700 Fn3-45 42 rs2048488125 0.9068 None 1.0 N 0.673 0.561 0.611786747218 gnomAD-4.0.0 6.57678E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47093E-05 0 0
K/T 21798 Fn3-46 42 rs776173264 0.4171 -0.616 1.0 N 0.727 0.464 0.483521307902 gnomAD-2.1.1 4.11E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.1E-06 0
E/G 21997 Fn3-47 42 None 0.9828 None 0.999 N 0.674 0.576 0.491729458163 gnomAD-4.0.0 2.40067E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62503E-06 0 0
E/K 21997 Fn3-47 42 rs1228774408 0.9864 -1.287 0.998 N 0.503 0.333 0.37097340754 gnomAD-2.1.1 8.07E-06 None None None None N None 0 5.81E-05 None 0 0 None 0 None 0 0 0
E/K 21997 Fn3-47 42 rs1228774408 0.9864 -1.287 0.998 N 0.503 0.333 0.37097340754 gnomAD-4.0.0 3.18629E-06 None None None None N None 0 4.57687E-05 None 0 0 None 0 0 0 0 0
E/K 22096 Fn3-48 42 None 0.6928 None 0.977 N 0.544 0.306 0.356281029322 gnomAD-4.0.0 1.5925E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86022E-06 0 0
R/Q 22197 Fn3-49 42 rs374656017 0.1496 -0.195 0.999 N 0.557 0.211 None gnomAD-2.1.1 9.69E-05 None None None None N None 3.73134E-04 0 None 0 6.78355E-04 None 3.28E-05 None 0 1.57E-05 2.83126E-04
R/Q 22197 Fn3-49 42 rs374656017 0.1496 -0.195 0.999 N 0.557 0.211 None gnomAD-3.1.2 1.57882E-04 None None None None N None 3.86287E-04 0 0 0 7.75795E-04 None 0 0 1.47E-05 2.079E-04 9.5511E-04
R/Q 22197 Fn3-49 42 rs374656017 0.1496 -0.195 0.999 N 0.557 0.211 None gnomAD-4.0.0 6.38772E-05 None None None None N None 2.80142E-04 0 None 0 6.50603E-04 None 0 0 2.54415E-05 6.59558E-05 2.72357E-04
R/W 22197 Fn3-49 42 rs774696610 0.4251 -0.581 1.0 N 0.723 0.282 None gnomAD-2.1.1 2.51E-05 None None None None N None 2.07366E-04 0 None 0 0 None 0 None 0 1.57E-05 0
R/W 22197 Fn3-49 42 rs774696610 0.4251 -0.581 1.0 N 0.723 0.282 None gnomAD-3.1.2 5.26E-05 None None None None N None 1.69049E-04 0 0 0 0 None 0 0 1.47E-05 0 0
R/W 22197 Fn3-49 42 rs774696610 0.4251 -0.581 1.0 N 0.723 0.282 None gnomAD-4.0.0 1.05438E-05 None None None None N None 1.20276E-04 0 None 0 2.24215E-05 None 0 0 3.3923E-06 0 4.80769E-05
D/E 22395 Fn3-50 42 rs924623124 0.3422 -0.689 0.003 N 0.099 0.053 0.124217242631 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.67317E-04 None 0 None 0 0 0
D/E 22395 Fn3-50 42 rs924623124 0.3422 -0.689 0.003 N 0.099 0.053 0.124217242631 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94175E-04 None 0 0 0 0 0
D/E 22395 Fn3-50 42 rs924623124 0.3422 -0.689 0.003 N 0.099 0.053 0.124217242631 gnomAD-4.0.0 5.12713E-06 None None None None N None 0 0 None 0 9.71251E-05 None 0 0 0 0 0
D/N 22395 Fn3-50 42 None 0.3432 None 0.684 N 0.465 0.21 0.361758802978 gnomAD-4.0.0 1.59214E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02608E-05
D/V 22395 Fn3-50 42 None 0.561 None 0.521 N 0.499 0.251 0.452928561435 gnomAD-4.0.0 1.59214E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02608E-05
T/N 22492 Fn3-51 42 rs1268182721 0.1109 -0.665 0.029 N 0.324 0.049 0.177238962908 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
T/S 22492 Fn3-51 42 None 0.1022 None None N 0.106 0.097 0.0884992946249 gnomAD-4.0.0 2.05322E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69897E-06 0 0
D/N 22685 Fn3-52 43 rs866478447 0.4318 None 0.684 N 0.383 0.252 0.32082282376 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
D/N 22685 Fn3-52 43 rs866478447 0.4318 None 0.684 N 0.383 0.252 0.32082282376 gnomAD-4.0.0 6.57999E-06 None None None None N None 2.41534E-05 0 None 0 0 None 0 0 0 0 0
E/K 22784 Fn3-53 42 rs1423648586 0.9312 -0.262 0.992 N 0.515 0.376 0.373173300195 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
E/K 22784 Fn3-53 42 rs1423648586 0.9312 -0.262 0.992 N 0.515 0.376 0.373173300195 gnomAD-4.0.0 1.59477E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43476E-05 0
D/E 22882 Fn3-54 42 None 0.1234 None 0.001 N 0.195 0.039 0.168933306366 gnomAD-4.0.0 1.59244E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02535E-05
K/R 23281 Fn3-57 42 None 0.0982 None 0.085 N 0.236 0.18 0.306695030598 gnomAD-4.0.0 1.62571E-06 None None None None N None 0 0 None 0 0 None 0 0 2.90298E-06 0 0
Q/P 23768 Fn3-60 43 None 0.1408 None 0.784 N 0.483 0.302 0.317378411342 gnomAD-4.0.0 6.16112E-06 None None None None N None 0 0 None 0 0 None 0 0 8.09779E-06 0 0
D/E 23965 Fn3-62 42 rs772655984 0.2195 -0.564 0.198 N 0.148 0.033 0.271763555656 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/E 23965 Fn3-62 42 rs772655984 0.2195 -0.564 0.198 N 0.148 0.033 0.271763555656 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/E 23965 Fn3-62 42 rs772655984 0.2195 -0.564 0.198 N 0.148 0.033 0.271763555656 gnomAD-4.0.0 3.71956E-06 None None None None N None 0 0 None 0 0 None 0 0 4.2392E-06 1.09825E-05 0
D/Y 23965 Fn3-62 42 rs1709278719 0.4349 None 1.0 N 0.753 0.575 0.764077007804 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 9.41E-05 0 1.47E-05 0 0
D/Y 23965 Fn3-62 42 rs1709278719 0.4349 None 1.0 N 0.753 0.575 0.764077007804 gnomAD-4.0.0 2.47968E-06 None None None None N None 0 0 None 0 0 None 1.5627E-05 0 2.54357E-06 0 0
E/A 24560 Fn3-66 42 None 0.8992 None 0.914 N 0.481 0.395 0.437958778045 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
T/P 24657 Fn3-67 42 None 0.0683 None 0.011 N 0.405 0.117 0.194818534648 gnomAD-4.0.0 1.59207E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85928E-06 0 0
D/G 24850 Fn3-68 43 rs573415766 0.777 -0.872 0.834 N 0.693 0.447 0.346085882481 gnomAD-2.1.1 2.87354E-04 None None None None N None 0 0 None 0 0 None 2.58542E-03 None 0 7.89E-06 0
D/G 24850 Fn3-68 43 rs573415766 0.777 -0.872 0.834 N 0.693 0.447 0.346085882481 gnomAD-3.1.2 1.70938E-04 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 4.76191E-03 0
D/G 24850 Fn3-68 43 rs573415766 0.777 -0.872 0.834 N 0.693 0.447 0.346085882481 1000 genomes 1.39776E-03 None None None None N None 0 0 None None 0 0 None None None 7.2E-03 None
D/G 24850 Fn3-68 43 rs573415766 0.777 -0.872 0.834 N 0.693 0.447 0.346085882481 gnomAD-4.0.0 1.8906E-04 None None None None N None 2.66596E-05 0 None 0 0 None 0 0 5.93441E-06 3.1298E-03 1.76152E-04
E/G 24949 Fn3-69 42 rs1179463518 0.5916 -1.295 0.993 N 0.664 0.555 0.461671691612 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66058E-04
E/G 24949 Fn3-69 42 rs1179463518 0.5916 -1.295 0.993 N 0.664 0.555 0.461671691612 gnomAD-4.0.0 1.59182E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
E/Q 24949 Fn3-69 42 rs753903335 0.534 -0.765 0.997 N 0.635 0.31 0.368369118721 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
E/Q 24949 Fn3-69 42 rs753903335 0.534 -0.765 0.997 N 0.635 0.31 0.368369118721 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
E/Q 24949 Fn3-69 42 rs753903335 0.534 -0.765 0.997 N 0.635 0.31 0.368369118721 gnomAD-4.0.0 6.57903E-06 None None None None N None 2.41581E-05 0 None 0 0 None 0 0 0 0 0
D/N 25345 Fn3-72 42 rs776220122 0.49 -1.387 1.0 N 0.668 0.397 0.481915485015 gnomAD-2.1.1 8.05E-06 None None None None N None 1.29232E-04 0 None 0 0 None 0 None 0 0 0
D/N 25345 Fn3-72 42 rs776220122 0.49 -1.387 1.0 N 0.668 0.397 0.481915485015 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
D/N 25345 Fn3-72 42 rs776220122 0.49 -1.387 1.0 N 0.668 0.397 0.481915485015 gnomAD-4.0.0 3.84517E-06 None None None None N None 5.07786E-05 0 None 0 0 None 0 0 0 0 0
E/K 25642 Fn3-74 42 rs1455903337 0.93 -0.891 0.065 N 0.331 0.271 0.32306181527 gnomAD-4.0.0 1.6038E-06 None None None None N None 0 0 None 0 2.77639E-05 None 0 0 0 0 0
A/G 25739 Fn3-75 42 rs56391938 0.1155 -1.482 0.946 N 0.478 0.198 None gnomAD-2.1.1 5.3937E-04 None None None None N None 4.14E-05 2.26308E-04 None 0 0 None 0 None 4.02E-05 1.0937E-03 1.4041E-04
A/G 25739 Fn3-75 42 rs56391938 0.1155 -1.482 0.946 N 0.478 0.198 None gnomAD-3.1.2 4.93467E-04 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.07413E-03 0 0
A/G 25739 Fn3-75 42 rs56391938 0.1155 -1.482 0.946 N 0.478 0.198 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
A/G 25739 Fn3-75 42 rs56391938 0.1155 -1.482 0.946 N 0.478 0.198 None gnomAD-4.0.0 7.34547E-04 None None None None N None 9.33657E-05 2.83437E-04 None 0 0 None 4.6991E-05 0 9.58829E-04 0 4.32235E-04
A/P 25739 Fn3-75 42 None 0.1241 None 0.011 N 0.265 0.232 0.227260227426 gnomAD-4.0.0 1.59227E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02535E-05
D/E 25932 Fn3-76 43 None 0.2659 None 1.0 N 0.427 0.182 0.21279746466 gnomAD-4.0.0 1.36874E-06 None None None None N None 0 0 None 0 0 None 0 1.7343E-04 8.99586E-07 0 0
D/G 25932 Fn3-76 43 None 0.6849 None 1.0 N 0.703 0.512 0.297718772494 gnomAD-4.0.0 1.59211E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
D/N 25932 Fn3-76 43 rs778532395 0.2571 -0.815 1.0 N 0.605 0.406 0.354610295913 gnomAD-2.1.1 1.21E-05 None None None None N None 0 5.81E-05 None 0 0 None 0 None 0 0 1.66389E-04
D/N 25932 Fn3-76 43 rs778532395 0.2571 -0.815 1.0 N 0.605 0.406 0.354610295913 gnomAD-4.0.0 2.73748E-06 None None None None N None 0 6.71261E-05 None 0 2.52589E-05 None 0 0 0 0 0
D/Y 25932 Fn3-76 43 None 0.7074 None 1.0 D 0.783 0.549 0.75727360634 gnomAD-4.0.0 6.8437E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99586E-07 0 0
D/G 26129 Fn3-78 42 rs1297041151 0.5492 -1.536 0.989 N 0.665 0.516 0.404453528171 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
D/G 26129 Fn3-78 42 rs1297041151 0.5492 -1.536 0.989 N 0.665 0.516 0.404453528171 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/G 26129 Fn3-78 42 rs1297041151 0.5492 -1.536 0.989 N 0.665 0.516 0.404453528171 gnomAD-4.0.0 6.57523E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47106E-05 0 0
D/Y 26129 Fn3-78 42 rs199814673 0.5333 -0.609 1.0 N 0.786 0.532 None gnomAD-2.1.1 9.68E-05 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 1.96267E-04 1.66556E-04
D/Y 26129 Fn3-78 42 rs199814673 0.5333 -0.609 1.0 N 0.786 0.532 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 6.56E-05 0 0 0 None 0 0 2.94E-05 0 4.77555E-04
D/Y 26129 Fn3-78 42 rs199814673 0.5333 -0.609 1.0 N 0.786 0.532 None gnomAD-4.0.0 8.33598E-05 None None None None N None 0 1.69653E-05 None 0 0 None 4.70972E-05 0 1.1502E-04 0 3.70181E-04
E/A 26328 Fn3-79 43 rs746887830 0.9839 -1.154 0.999 N 0.645 0.64 0.572001775666 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
E/A 26328 Fn3-79 43 rs746887830 0.9839 -1.154 0.999 N 0.645 0.64 0.572001775666 gnomAD-4.0.0 1.59186E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85951E-06 0 0
D/E 26427 Fn3-80 42 rs766994654 0.7597 -0.658 0.067 N 0.272 0.07 0.239901079897 gnomAD-2.1.1 3.22E-05 None None None None N None 0 0 None 0 0 None 0 None 0 7.06E-05 0
D/E 26427 Fn3-80 42 rs766994654 0.7597 -0.658 0.067 N 0.272 0.07 0.239901079897 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
D/E 26427 Fn3-80 42 rs766994654 0.7597 -0.658 0.067 N 0.272 0.07 0.239901079897 gnomAD-4.0.0 6.84363E-07 None None None None N None 0 0 None 0 2.52385E-05 None 0 0 0 0 0
D/H 26427 Fn3-80 42 rs1157004476 0.9437 None 0.998 N 0.755 0.489 0.40417439687 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/H 26427 Fn3-80 42 rs1157004476 0.9437 None 0.998 N 0.755 0.489 0.40417439687 gnomAD-4.0.0 6.57462E-06 None None None None N None 2.41348E-05 0 None 0 0 None 0 0 0 0 0
D/N 26427 Fn3-80 42 rs1157004476 0.7934 None 0.988 N 0.645 0.375 0.342400092842 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
D/N 26427 Fn3-80 42 rs1157004476 0.7934 None 0.988 N 0.645 0.375 0.342400092842 gnomAD-4.0.0 1.59205E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02554E-05
K/E 26528 Fn3-81 42 rs775724652 0.1632 -0.207 0.994 N 0.447 0.322 0.312001716656 gnomAD-2.1.1 1.21E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 3.31785E-04
K/E 26528 Fn3-81 42 rs775724652 0.1632 -0.207 0.994 N 0.447 0.322 0.312001716656 gnomAD-3.1.2 1.97E-05 None None None None N None 0 1.3113E-04 0 0 0 None 0 0 0 0 4.78011E-04
K/E 26528 Fn3-81 42 rs775724652 0.1632 -0.207 0.994 N 0.447 0.322 0.312001716656 gnomAD-4.0.0 3.09947E-06 None None None None N None 0 3.335E-05 None 0 0 None 0 0 8.47672E-07 0 3.20277E-05
E/K 26724 Fn3-82 42 rs367812761 0.9007 None 1.0 N 0.544 0.505 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/K 26724 Fn3-82 42 rs367812761 0.9007 None 1.0 N 0.544 0.505 None gnomAD-4.0.0 3.84409E-06 None None None None N None 0 0 None 0 0 None 0 0 7.18081E-06 0 0
P/L 26821 Fn3-83 42 rs200489046 0.1108 -0.454 0.901 N 0.585 0.351 None gnomAD-2.1.1 8.46E-05 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 1.78301E-04 0
P/L 26821 Fn3-83 42 rs200489046 0.1108 -0.454 0.901 N 0.585 0.351 None gnomAD-3.1.2 8.56E-05 None None None None N None 0 0 0 0 0 None 0 6.32911E-03 1.61827E-04 0 0
P/L 26821 Fn3-83 42 rs200489046 0.1108 -0.454 0.901 N 0.585 0.351 None gnomAD-4.0.0 1.88417E-04 None None None None N None 2.66902E-05 0 None 0 0 None 0 4.95213E-04 2.49232E-04 0 8.00512E-05
P/S 26821 Fn3-83 42 rs560861418 0.1523 -1.589 0.034 N 0.311 0.145 0.154104182512 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
P/S 26821 Fn3-83 42 rs560861418 0.1523 -1.589 0.034 N 0.311 0.145 0.154104182512 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
P/S 26821 Fn3-83 42 rs560861418 0.1523 -1.589 0.034 N 0.311 0.145 0.154104182512 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
P/S 26821 Fn3-83 42 rs560861418 0.1523 -1.589 0.034 N 0.311 0.145 0.154104182512 gnomAD-4.0.0 3.71853E-06 None None None None N None 0 1.66711E-05 None 0 0 None 0 0 8.47728E-07 4.39174E-05 0
D/E 27014 Fn3-84 43 rs1468937743 0.2896 None 0.117 N 0.295 0.089 0.223146558224 gnomAD-4.0.0 6.84284E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9956E-07 0 0
D/N 27014 Fn3-84 43 rs1195586703 0.3188 -0.83 0.993 N 0.617 0.428 0.371903410333 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/N 27014 Fn3-84 43 rs1195586703 0.3188 -0.83 0.993 N 0.617 0.428 0.371903410333 gnomAD-4.0.0 1.59167E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85919E-06 0 0
D/V 27014 Fn3-84 43 rs954420443 0.6594 None 0.997 N 0.821 0.617 0.564579235405 gnomAD-4.0.0 1.59169E-06 None None None None N None 0 2.28686E-05 None 0 0 None 0 0 0 0 0
D/N 27211 Fn3-86 42 rs747343429 0.2013 -1.31 0.801 N 0.48 0.288 0.36453787251 gnomAD-2.1.1 4.09E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.08E-06 0
D/N 27211 Fn3-86 42 rs747343429 0.2013 -1.31 0.801 N 0.48 0.288 0.36453787251 gnomAD-4.0.0 2.73964E-06 None None None None N None 0 0 None 0 2.53241E-05 None 0 0 0 0 4.97595E-05
D/G 27510 Fn3-88 42 rs747295333 0.7922 -0.963 0.958 N 0.691 0.433 0.384919354899 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/G 27510 Fn3-88 42 rs747295333 0.7922 -0.963 0.958 N 0.691 0.433 0.384919354899 gnomAD-4.0.0 1.59125E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
D/N 27510 Fn3-88 42 None 0.5132 None 0.988 N 0.644 0.383 0.457013227636 gnomAD-4.0.0 1.59126E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85838E-06 0 0
E/D 27611 Fn3-89 42 None 0.1502 None 0.001 N 0.229 0.053 0.276065633971 gnomAD-4.0.0 1.59159E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85878E-06 0 0
E/G 27611 Fn3-89 42 None 0.2384 None 0.22 N 0.595 0.312 0.31077124679 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/Q 27611 Fn3-89 42 rs759363145 0.1888 -0.366 0.331 N 0.524 0.137 0.243972157842 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
E/Q 27611 Fn3-89 42 rs759363145 0.1888 -0.366 0.331 N 0.524 0.137 0.243972157842 gnomAD-4.0.0 3.18315E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71765E-06 0 0
E/G 27807 Fn3-90 42 None 0.8371 None 0.986 N 0.628 0.563 0.485634191555 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
E/Q 27807 Fn3-90 42 rs1439000157 0.7409 -1.067 0.99 N 0.543 0.251 0.411932830014 gnomAD-2.1.1 4.23E-06 None None None None N None 0 3.13E-05 None 0 0 None 0 None 0 0 0
E/Q 27807 Fn3-90 42 rs1439000157 0.7409 -1.067 0.99 N 0.543 0.251 0.411932830014 gnomAD-4.0.0 1.63494E-06 None None None None N None 0 2.4505E-05 None 0 0 None 0 0 0 0 0
T/A 27904 Fn3-91 42 rs1320086002 0.0726 -0.98 0.045 N 0.296 0.093 0.139678290688 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 9.97E-05 0 None 0 None 0 0 0
T/A 27904 Fn3-91 42 rs1320086002 0.0726 -0.98 0.045 N 0.296 0.093 0.139678290688 gnomAD-4.0.0 1.59303E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02627E-05
T/I 27904 Fn3-91 42 rs1704030695 0.1591 None 0.62 N 0.384 0.174 0.245101548738 gnomAD-4.0.0 3.18637E-06 None None None None N None 0 0 None 0 5.55772E-05 None 0 0 0 0 0
E/G 28195 Fn3-93 42 None 0.6227 None 0.978 N 0.56 0.45 0.504480301252 gnomAD-4.0.0 1.59262E-06 None None None None N None 0 0 None 0 2.77948E-05 None 0 0 0 0 0
E/G 28293 Fn3-94 42 rs879026651 0.3226 None 0.988 N 0.612 0.479 None gnomAD-4.0.0 1.59137E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85811E-06 0 0
E/G 28492 Fn3-95 43 None 0.5675 None 0.988 N 0.695 0.529 0.615496883321 gnomAD-4.0.0 2.05284E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69841E-06 0 0
E/K 28492 Fn3-95 43 None 0.4864 None 0.958 N 0.503 0.359 0.467585353272 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/Q 28492 Fn3-95 43 None 0.371 None 0.994 N 0.633 0.351 0.421184727016 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
E/V 28492 Fn3-95 43 rs771012463 0.7062 -0.155 0.994 N 0.795 0.563 0.7378300549 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
E/V 28492 Fn3-95 43 rs771012463 0.7062 -0.155 0.994 N 0.795 0.563 0.7378300549 gnomAD-4.0.0 1.36856E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79894E-06 0 0
E/K 28591 Fn3-96 42 None 0.7914 None 0.999 N 0.592 0.378 0.453307948783 gnomAD-4.0.0 2.737E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59789E-06 0 0
E/Q 28591 Fn3-96 42 rs556819067 0.5315 None 1.0 N 0.619 0.259 0.329020015101 gnomAD-4.0.0 6.84251E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99473E-07 0 0
K/N 28692 Fn3-97 42 None 0.3039 None None N 0.08 0.111 0.0401082797425 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/R 28692 Fn3-97 42 None 0.0819 None None N 0.105 0.116 0.0611884634855 gnomAD-4.0.0 1.59151E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85817E-06 0 0
E/D 28886 Fn3-98 42 rs760858743 0.5272 -1.325 0.996 N 0.481 0.194 0.27479166964 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
E/D 28886 Fn3-98 42 rs760858743 0.5272 -1.325 0.996 N 0.481 0.194 0.27479166964 gnomAD-4.0.0 6.84256E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99518E-07 0 0
E/Q 28886 Fn3-98 42 None 0.706 None 1.0 N 0.608 0.353 0.361958692863 gnomAD-4.0.0 1.59146E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85871E-06 0 0
E/Q 28983 Fn3-99 42 None 0.1519 None 1.0 N 0.621 0.332 0.368743488249 gnomAD-4.0.0 1.32035E-05 None None None None N None 0 0 None 0 0 None 0 0 1.44375E-05 0 0
E/A 29179 Fn3-100 43 None 0.2653 None 0.999 N 0.629 0.568 0.384584525793 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
E/D 29179 Fn3-100 43 None 0.1936 None 0.999 N 0.463 0.193 0.272205846399 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
D/E 29376 Fn3-102 42 rs1294808969 0.1981 None 0.767 N 0.175 0.111 0.329282125956 gnomAD-4.0.0 1.36846E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79888E-06 0 0
D/V 29376 Fn3-102 42 None 0.2976 None 0.999 N 0.819 0.401 0.588051273532 gnomAD-4.0.0 1.59138E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
D/N 29674 Fn3-104 42 None 0.2138 None 0.989 N 0.509 0.342 0.388970301349 gnomAD-4.0.0 1.59111E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
Q/H 29775 Fn3-105 42 None 0.2092 None 0.47 N 0.285 0.059 0.323615622048 gnomAD-4.0.0 1.59116E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85801E-06 0 0
Q/R 29775 Fn3-105 42 None 0.095 None 0.049 N 0.216 0.116 0.211220785272 gnomAD-4.0.0 1.59118E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
G/C 30071 Fn3-107 42 None 0.1858 None 0.295 N 0.611 0.145 0.350088858571 gnomAD-4.0.0 1.59106E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85788E-06 0 0
G/D 30071 Fn3-107 42 rs146338537 0.2345 -0.685 0.029 N 0.557 0.102 None gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
G/D 30071 Fn3-107 42 rs146338537 0.2345 -0.685 0.029 N 0.557 0.102 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/D 30071 Fn3-107 42 rs146338537 0.2345 -0.685 0.029 N 0.557 0.102 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
G/D 30071 Fn3-107 42 rs146338537 0.2345 -0.685 0.029 N 0.557 0.102 None gnomAD-4.0.0 2.5614E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78538E-06 0 0
E/G 30266 Fn3-108 43 None 0.6521 None 1.0 N 0.693 0.522 0.483521307902 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/Q 30760 Fn3-112 42 rs936029222 0.6459 -0.517 0.989 N 0.583 0.335 0.406806705197 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
E/Q 30760 Fn3-112 42 rs936029222 0.6459 -0.517 0.989 N 0.583 0.335 0.406806705197 gnomAD-4.0.0 1.59116E-06 None None None None N None 0 0 None 0 2.77285E-05 None 0 0 0 0 0
K/N 30862 Fn3-113 42 None 0.6678 None 0.99 N 0.691 0.274 0.198526703765 gnomAD-4.0.0 2.05253E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69828E-06 0 0
E/D 31057 Fn3-114 42 rs759940210 0.369 None 0.999 N 0.494 0.173 0.254244900254 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07555E-04 0
E/D 31057 Fn3-114 42 rs759940210 0.369 None 0.999 N 0.494 0.173 0.254244900254 gnomAD-4.0.0 1.85904E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.29395E-05 0
E/G 31057 Fn3-114 42 rs1353038457 0.7668 None 1.0 N 0.704 0.559 0.603539076606 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.9305E-04 None 0 0 0 0 0
E/G 31057 Fn3-114 42 rs1353038457 0.7668 None 1.0 N 0.704 0.559 0.603539076606 gnomAD-4.0.0 6.5741E-06 None None None None N None 0 0 None 0 1.9305E-04 None 0 0 0 0 0
E/K 31057 Fn3-114 42 rs767977295 0.8257 -0.556 0.999 N 0.581 0.416 0.486422812247 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
E/K 31057 Fn3-114 42 rs767977295 0.8257 -0.556 0.999 N 0.581 0.416 0.486422812247 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 31057 Fn3-114 42 rs767977295 0.8257 -0.556 0.999 N 0.581 0.416 0.486422812247 gnomAD-4.0.0 6.57125E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46981E-05 0 0
E/Q 31350 Fn3-116 43 None 0.3574 None 1.0 N 0.616 0.333 0.4018988957 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 31449 Fn3-117 42 rs374474093 0.9831 -0.659 0.999 N 0.576 0.41 0.392855499163 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
E/K 31449 Fn3-117 42 rs374474093 0.9831 -0.659 0.999 N 0.576 0.41 0.392855499163 gnomAD-4.0.0 6.84196E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99468E-07 0 0
E/Q 31449 Fn3-117 42 rs374474093 0.9153 -0.915 1.0 N 0.619 0.423 None gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
E/A 31749 Fn3-119 42 None 0.9492 None 0.999 N 0.643 0.563 0.435699915968 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
E/D 31749 Fn3-119 42 None 0.8144 None 0.999 N 0.458 0.141 0.388653054685 gnomAD-4.0.0 6.84213E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
E/K 31749 Fn3-119 42 rs139542862 0.972 -0.806 1.0 N 0.573 0.419 None gnomAD-2.1.1 8.57E-05 None None None None N None 2.89304E-04 2.83E-05 None 0 0 None 3.27E-05 None 0 1.17277E-04 0
E/K 31749 Fn3-119 42 rs139542862 0.972 -0.806 1.0 N 0.573 0.419 None gnomAD-3.1.2 1.24882E-04 None None None None N None 2.65508E-04 0 0 0 0 None 0 0 1.17599E-04 0 0
E/K 31749 Fn3-119 42 rs139542862 0.972 -0.806 1.0 N 0.573 0.419 None 1000 genomes 3.99361E-04 None None None None N None 1.5E-03 0 None None 0 0 None None None 0 None
E/K 31749 Fn3-119 42 rs139542862 0.972 -0.806 1.0 N 0.573 0.419 None gnomAD-4.0.0 6.07269E-05 None None None None N None 1.99957E-04 0 None 0 0 None 3.12471E-05 0 6.61135E-05 2.19573E-05 1.60072E-05
E/K 31950 Fn3-121 42 rs727505199 0.1299 -0.651 0.999 N 0.559 0.401 0.344945010812 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
E/K 31950 Fn3-121 42 rs727505199 0.1299 -0.651 0.999 N 0.559 0.401 0.344945010812 gnomAD-4.0.0 1.36847E-06 None None None None N None 2.98793E-05 0 None 0 0 None 0 0 0 1.15934E-05 0
E/V 32146 Fn3-122 42 rs1455005015 0.6899 -0.061 1.0 N 0.801 0.55 0.528260413467 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/V 32146 Fn3-122 42 rs1455005015 0.6899 -0.061 1.0 N 0.801 0.55 0.528260413467 gnomAD-4.0.0 1.59367E-06 None None None None N None 0 2.28728E-05 None 0 0 None 0 0 0 0 0
K/N 32243 Fn3-123 42 None 0.7952 None 0.638 N 0.601 0.109 0.19670166235 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
D/N 32441 Fn3-124 43 rs1232609141 0.471 -1.417 0.999 N 0.613 0.427 0.442567846599 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/N 32441 Fn3-124 43 rs1232609141 0.471 -1.417 0.999 N 0.613 0.427 0.442567846599 gnomAD-4.0.0 1.59157E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
E/Q 32837 Fn3-127 43 None 0.5419 None 1.0 N 0.627 0.321 0.52170519339 gnomAD-4.0.0 1.59111E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85814E-06 0 0
E/Q 32938 Fn3-128 43 rs1170456580 0.6253 -0.45 1.0 N 0.601 0.278 0.225215365344 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/Q 32938 Fn3-128 43 rs1170456580 0.6253 -0.45 1.0 N 0.601 0.278 0.225215365344 gnomAD-4.0.0 1.5913E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
Q/E 33039 Fn3-129 42 rs775875875 0.1176 -0.345 0.4 N 0.099 0.202 0.165133752707 gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 9.66E-05 0 None 0 None 0 1.56E-05 0
Q/E 33039 Fn3-129 42 rs775875875 0.1176 -0.345 0.4 N 0.099 0.202 0.165133752707 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 2.88184E-04 0 None 0 0 2.94E-05 0 0
Q/E 33039 Fn3-129 42 rs775875875 0.1176 -0.345 0.4 N 0.099 0.202 0.165133752707 gnomAD-4.0.0 8.67606E-06 None None None None N None 0 0 None 1.35126E-04 0 None 0 0 7.62868E-06 0 1.60113E-05
Q/H 33039 Fn3-129 42 None 0.3222 None 0.999 N 0.481 0.305 0.230578612272 gnomAD-4.0.0 6.84217E-07 None None None None N None 2.98846E-05 0 None 0 0 None 0 0 0 0 0
E/G 33332 Fn3-130 43 rs1407789736 0.503 -1.485 1.0 N 0.691 0.574 0.503311249505 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
E/G 33332 Fn3-130 43 rs1407789736 0.503 -1.485 1.0 N 0.691 0.574 0.503311249505 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 33332 Fn3-130 43 rs1407789736 0.503 -1.485 1.0 N 0.691 0.574 0.503311249505 gnomAD-4.0.0 4.3393E-06 None None None None N None 0 0 None 0 0 None 0 0 5.93423E-06 0 0
E/K 33332 Fn3-130 43 rs1327630158 0.3074 -0.817 0.999 N 0.573 0.438 0.424908009808 gnomAD-4.0.0 1.59249E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85966E-06 0 0
E/D 33433 Fn3-131 42 rs879015914 0.4427 -1.188 0.275 N 0.186 0.038 0.289474373501 gnomAD-2.1.1 2.03E-05 None None None None N None 2.58766E-04 0 None 0 0 None 0 None 0 0 1.67448E-04
E/D 33433 Fn3-131 42 rs879015914 0.4427 -1.188 0.275 N 0.186 0.038 0.289474373501 gnomAD-3.1.2 5.26E-05 None None None None N None 1.92911E-04 0 0 0 0 None 0 0 0 0 0
E/D 33433 Fn3-131 42 rs879015914 0.4427 -1.188 0.275 N 0.186 0.038 0.289474373501 gnomAD-4.0.0 7.4495E-06 None None None None N None 1.47141E-04 0 None 0 0 None 0 0 0 0 1.60426E-05
A/V 33730 Fn3-132 42 rs1690988435 0.5018 None 0.999 N 0.564 0.355 0.377097596864 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07383E-04 0
A/V 33730 Fn3-132 42 rs1690988435 0.5018 None 0.999 N 0.564 0.355 0.377097596864 gnomAD-4.0.0 2.56211E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.68025E-05 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.