Structural position:

  • Domain Type: Fn3
  • Aligned Position: 63
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
K/M 15702 Fn3-1 46 None 0.7739 None 1.0 N 0.659 0.541 0.376393476264 gnomAD-4.0.0 3.42319E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49948E-06 0 0
I/V 15803 Fn3-2 46 rs794729441 0.0919 None 0.061 N 0.165 0.11 None gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 3.9032E-04 None 0 0 0 0 0
I/V 15803 Fn3-2 46 rs794729441 0.0919 None 0.061 N 0.165 0.11 None gnomAD-4.0.0 5.13084E-06 None None None None I None 0 1.69687E-05 None 0 4.86547E-05 None 0 0 0 1.34048E-05 0
D/G 15904 Fn3-3 46 None 0.1019 None 1.0 N 0.58 0.513 0.333154297509 gnomAD-4.0.0 3.48457E-06 None None None None N None 0 0 None 0 2.56253E-05 None 0 0 3.63026E-06 0 0
K/E 16100 Fn3-4 46 None 0.5765 None 0.999 N 0.631 0.369 0.28798054836 gnomAD-4.0.0 1.59465E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43451E-05 0
E/K 16396 Fn3-6 46 None 0.1643 None 0.334 N 0.543 0.242 0.285698343383 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/H 16495 Fn3-7 46 rs1424817630 0.4219 0.647 1.0 N 0.57 0.383 0.344017737713 gnomAD-2.1.1 1.21E-05 None None None None N None 0 8.7E-05 None 0 0 None 0 None 0 0 0
D/H 16495 Fn3-7 46 rs1424817630 0.4219 0.647 1.0 N 0.57 0.383 0.344017737713 gnomAD-4.0.0 4.78123E-06 None None None None N None 0 6.86373E-05 None 0 0 None 0 0 0 0 0
D/A 16596 Fn3-8 46 rs1353241545 0.137 0.317 0.027 N 0.319 0.145 0.270001397563 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/A 16596 Fn3-8 46 rs1353241545 0.137 0.317 0.027 N 0.319 0.145 0.270001397563 gnomAD-4.0.0 1.5935E-06 None None None None N None 0 2.28938E-05 None 0 0 None 0 0 0 0 0
K/N 16696 Fn3-9 46 rs745412383 0.917 0.215 1.0 N 0.657 0.276 0.207176502487 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9E-06 0
K/N 16696 Fn3-9 46 rs745412383 0.917 0.215 1.0 N 0.657 0.276 0.207176502487 gnomAD-4.0.0 1.59406E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86234E-06 0 0
R/K 17092 Fn3-12 46 rs1207362275 0.3264 0.134 0.046 N 0.467 0.107 0.238096912614 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
R/K 17092 Fn3-12 46 rs1207362275 0.3264 0.134 0.046 N 0.467 0.107 0.238096912614 gnomAD-4.0.0 6.84498E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99815E-06 0 0
T/I 17514 Fn3-15 45 None 0.2916 None 0.997 N 0.357 0.441 0.386558576397 gnomAD-4.0.0 1.3696E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79979E-06 0 0
T/P 17514 Fn3-15 45 rs1470590917 0.1591 None 0.997 N 0.359 0.334 0.333906830038 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 2.88018E-04 0 None 0 0 0 0 0
T/P 17514 Fn3-15 45 rs1470590917 0.1591 None 0.997 N 0.359 0.334 0.333906830038 gnomAD-4.0.0 6.58025E-06 None None None None N None 0 0 None 2.88018E-04 0 None 0 0 0 0 0
N/D 17614 Fn3-16 46 None 0.0994 None 0.801 N 0.271 0.199 0.16115917748 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/S 17614 Fn3-16 46 rs1162109348 0.067 0.235 0.136 N 0.137 0.17 0.128392430309 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
N/S 17614 Fn3-16 46 rs1162109348 0.067 0.235 0.136 N 0.137 0.17 0.128392430309 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/S 17614 Fn3-16 46 rs1162109348 0.067 0.235 0.136 N 0.137 0.17 0.128392430309 gnomAD-4.0.0 6.5825E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47241E-05 0 0
H/R 17809 Fn3-17 46 None 0.3549 None 0.961 N 0.481 0.424 0.232513804876 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
A/G 18112 Fn3-19 48 None 0.1116 None 0.012 N 0.303 0.081 0.0666544352282 gnomAD-4.0.0 1.59546E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86571E-06 0 0
A/T 18112 Fn3-19 48 None 0.0777 None None N 0.212 0.065 0.0611884634855 gnomAD-4.0.0 1.36986E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80033E-06 0 0
P/L 18211 Fn3-20 46 rs764772164 0.1059 -0.051 None N 0.215 0.088 0.222439326576 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/L 18211 Fn3-20 46 rs764772164 0.1059 -0.051 None N 0.215 0.088 0.222439326576 gnomAD-4.0.0 1.86004E-06 None None None None N None 0 1.66761E-05 None 0 0 None 0 0 1.69609E-06 0 0
P/R 18211 Fn3-20 46 rs764772164 0.1816 None 0.001 N 0.211 0.065 0.126345400529 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
P/R 18211 Fn3-20 46 rs764772164 0.1816 None 0.001 N 0.211 0.065 0.126345400529 gnomAD-4.0.0 1.67415E-05 None None None None N None 0 0 None 0 0 None 0 0 2.20491E-05 0 1.60231E-05
P/S 18211 Fn3-20 46 rs727504192 0.0875 None None N 0.161 0.067 0.0297737177859 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
P/S 18211 Fn3-20 46 rs727504192 0.0875 None None N 0.161 0.067 0.0297737177859 gnomAD-4.0.0 6.58085E-06 None None None None N None 2.41406E-05 0 None 0 0 None 0 0 0 0 0
P/T 18211 Fn3-20 46 rs727504192 0.0761 -0.331 None N 0.163 0.059 None gnomAD-2.1.1 7.86E-05 None None None None N None 0 2.83E-05 None 0 0 None 0 None 0 1.64317E-04 0
P/T 18211 Fn3-20 46 rs727504192 0.0761 -0.331 None N 0.163 0.059 None gnomAD-3.1.2 8.56E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.76606E-04 0 0
P/T 18211 Fn3-20 46 rs727504192 0.0761 -0.331 None N 0.163 0.059 None gnomAD-4.0.0 2.03997E-04 None None None None N None 8.01775E-05 0 None 0 0 None 0 0 2.55258E-04 0 3.52485E-04
T/A 18317 Fn3-21 46 rs1487036474 0.0665 0.005 0.099 N 0.317 0.053 0.202949470691 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
T/A 18317 Fn3-21 46 rs1487036474 0.0665 0.005 0.099 N 0.317 0.053 0.202949470691 gnomAD-4.0.0 1.59407E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86261E-06 0 0
K/N 18830 Fn3-24 47 rs1004119141 0.594 None 0.942 N 0.371 0.204 0.188950314367 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/N 18830 Fn3-24 47 rs1004119141 0.594 None 0.942 N 0.371 0.204 0.188950314367 gnomAD-4.0.0 2.57737E-06 None None None None N None 0 0 None 0 0 None 0 0 4.80467E-06 0 0
K/E 18929 Fn3-25 46 None 0.6167 None 0.999 N 0.676 0.36 0.323615622048 gnomAD-4.0.0 3.18554E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86015E-06 1.43349E-05 0
R/K 19229 Fn3-27 47 rs778237029 0.0752 0.11 0.003 N 0.27 0.057 0.0666544352282 gnomAD-2.1.1 4.16E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.2E-06 0
R/K 19229 Fn3-27 47 rs778237029 0.0752 0.11 0.003 N 0.27 0.057 0.0666544352282 gnomAD-4.0.0 5.49287E-06 None None None None N None 0 0 None 0 0 None 0 0 6.30905E-06 0 1.66091E-05
R/S 19229 Fn3-27 47 None 0.5906 None 0.338 N 0.493 0.104 0.149567049428 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
E/D 19329 Fn3-28 46 rs375818281 0.0925 -0.495 0.001 N 0.107 0.072 0.198526703765 gnomAD-2.1.1 7.14E-06 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 0 0
E/D 19329 Fn3-28 46 rs375818281 0.0925 -0.495 0.001 N 0.107 0.072 0.198526703765 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/D 19329 Fn3-28 46 rs375818281 0.0925 -0.495 0.001 N 0.107 0.072 0.198526703765 gnomAD-4.0.0 1.36875E-06 None None None None N None 5.97979E-05 0 None 0 0 None 0 0 0 0 0
E/Q 19329 Fn3-28 46 rs975610705 0.2867 -0.323 0.722 N 0.489 0.241 0.397838977388 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14732E-04 0 None 0 0 None 0 None 0 0 0
E/Q 19329 Fn3-28 46 rs975610705 0.2867 -0.323 0.722 N 0.489 0.241 0.397838977388 gnomAD-3.1.2 1.32E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
E/Q 19329 Fn3-28 46 rs975610705 0.2867 -0.323 0.722 N 0.489 0.241 0.397838977388 gnomAD-4.0.0 1.31501E-05 None None None None N None 4.82486E-05 0 None 0 0 None 0 0 0 0 0
E/K 19725 Fn3-31 46 rs767601396 0.1033 0.739 0.698 N 0.604 0.263 0.339316883193 gnomAD-2.1.1 1.79E-05 None None None None N None 4.13E-05 0 None 0 5.14E-05 None 0 None 0 2.35E-05 0
E/K 19725 Fn3-31 46 rs767601396 0.1033 0.739 0.698 N 0.604 0.263 0.339316883193 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/K 19725 Fn3-31 46 rs767601396 0.1033 0.739 0.698 N 0.604 0.263 0.339316883193 gnomAD-4.0.0 1.61151E-05 None None None None N None 0 0 None 0 2.23085E-05 None 0 0 1.94979E-05 1.09803E-05 1.60143E-05
E/Q 19725 Fn3-31 46 None 0.1359 None 0.294 N 0.495 0.173 0.31291088546 gnomAD-4.0.0 6.84294E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65689E-05
E/V 19725 Fn3-31 46 rs1434751540 0.1592 0.385 0.971 N 0.625 0.363 0.503186968135 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/V 19725 Fn3-31 46 rs1434751540 0.1592 0.385 0.971 N 0.625 0.363 0.503186968135 gnomAD-4.0.0 3.18343E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85938E-06 1.43283E-05 0
A/S 19922 Fn3-32 46 rs1054816991 0.0741 -0.249 0.002 N 0.147 0.061 0.124217242631 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
A/S 19922 Fn3-32 46 rs1054816991 0.0741 -0.249 0.002 N 0.147 0.061 0.124217242631 gnomAD-4.0.0 1.36911E-06 None None None None N None 0 2.24014E-05 None 0 0 None 0 0 8.99667E-07 0 0
A/T 19922 Fn3-32 46 rs1054816991 0.0693 -0.293 None N 0.107 0.08 0.139678290688 gnomAD-2.1.1 2.02E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.47E-05 0
A/T 19922 Fn3-32 46 rs1054816991 0.0693 -0.293 None N 0.107 0.08 0.139678290688 gnomAD-4.0.0 1.09529E-05 None None None None N None 0 0 None 0 5.06842E-05 None 0 1.73671E-04 8.09701E-06 0 6.63152E-05
Q/E 20022 Fn3-33 46 None 0.0465 None None N 0.08 0.17 0.0482279557977 gnomAD-4.0.0 1.59214E-06 None None None None N None 0 0 None 0 2.78118E-05 None 0 0 0 0 0
G/C 20315 Fn3-35 45 None 0.4373 None 1.0 N 0.735 0.457 0.765205214495 gnomAD-4.0.0 1.60829E-06 None None None None N None 0 0 None 0 0 None 0 0 2.90023E-06 0 0
G/D 20315 Fn3-35 45 rs765839032 0.6076 -0.543 1.0 N 0.609 0.428 0.241078983079 gnomAD-2.1.1 1.22E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
G/D 20315 Fn3-35 45 rs765839032 0.6076 -0.543 1.0 N 0.609 0.428 0.241078983079 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/D 20315 Fn3-35 45 rs765839032 0.6076 -0.543 1.0 N 0.609 0.428 0.241078983079 gnomAD-4.0.0 2.17837E-05 None None None None N None 0 0 None 0 0 None 0 0 2.97973E-05 0 0
G/V 20315 Fn3-35 45 rs765839032 0.6159 -0.233 1.0 N 0.713 0.405 0.723284658671 gnomAD-2.1.1 6.38E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 9.19118E-04
G/V 20315 Fn3-35 45 rs765839032 0.6159 -0.233 1.0 N 0.713 0.405 0.723284658671 gnomAD-3.1.2 1.97E-05 None None None None N None 0 6.56E-05 0 0 0 None 0 0 2.94E-05 0 0
G/V 20315 Fn3-35 45 rs765839032 0.6159 -0.233 1.0 N 0.713 0.405 0.723284658671 gnomAD-4.0.0 8.71347E-06 None None None None N None 1.33754E-05 1.67325E-05 None 0 0 None 0 0 9.36487E-06 0 1.60989E-05
D/N 20713 Fn3-38 46 rs1177521349 0.0651 0.623 0.248 N 0.388 0.062 0.139678290688 gnomAD-2.1.1 8.08E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.95E-06 0
D/N 20713 Fn3-38 46 rs1177521349 0.0651 0.623 0.248 N 0.388 0.062 0.139678290688 gnomAD-3.1.2 3.29E-05 None None None None N None 4.83E-05 1.31113E-04 0 0 0 None 0 0 1.47E-05 0 0
D/N 20713 Fn3-38 46 rs1177521349 0.0651 0.623 0.248 N 0.388 0.062 0.139678290688 gnomAD-4.0.0 1.4257E-05 None None None None N None 4.0063E-05 5.00367E-05 None 0 0 None 0 0 1.27164E-05 1.09823E-05 1.60128E-05
M/T 20909 Fn3-39 46 rs1474501322 0.4969 -0.556 0.994 N 0.348 0.436 0.771801801482 gnomAD-2.1.1 8.13E-06 None None None None N None 0 0 None 0 0 None 0 None 9.61E-05 0 0
M/T 20909 Fn3-39 46 rs1474501322 0.4969 -0.556 0.994 N 0.348 0.436 0.771801801482 gnomAD-4.0.0 5.48116E-06 None None None None N None 0 0 None 0 0 None 1.33787E-04 0 8.99789E-07 0 0
T/A 21008 Fn3-40 46 None 0.0641 None None N 0.073 0.054 0.0551355673512 gnomAD-4.0.0 6.84427E-07 None None None None N None 2.99043E-05 0 None 0 0 None 0 0 0 0 0
T/I 21008 Fn3-40 46 rs72646850 0.0678 0.106 None N 0.132 0.172 None gnomAD-2.1.1 9.0722E-03 None None None None N None 1.98478E-03 1.10457E-02 None 1.48055E-02 0 None 7.84673E-04 None 2.04114E-03 1.39345E-02 1.26547E-02
T/I 21008 Fn3-40 46 rs72646850 0.0678 0.106 None N 0.132 0.172 None gnomAD-3.1.2 9.87409E-03 None None None None N None 2.80044E-03 1.43026E-02 3.28947E-03 1.64265E-02 1.9478E-04 None 1.9774E-03 0 1.55202E-02 6.20604E-04 1.2931E-02
T/I 21008 Fn3-40 46 rs72646850 0.0678 0.106 None N 0.132 0.172 None 1000 genomes 5.79073E-03 None None None None N None 8E-04 1.59E-02 None None 0 1.69E-02 None None None 0 None
T/I 21008 Fn3-40 46 rs72646850 0.0678 0.106 None N 0.132 0.172 None gnomAD-4.0.0 1.23667E-02 None None None None N None 2.25375E-03 1.18079E-02 None 1.45359E-02 2.23524E-05 None 2.34382E-03 7.76603E-03 1.48871E-02 1.03249E-03 1.26329E-02
T/R 21008 Fn3-40 46 rs72646850 0.1717 0.223 0.033 N 0.302 0.165 0.0762999501168 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/R 21008 Fn3-40 46 rs72646850 0.1717 0.223 0.033 N 0.302 0.165 0.0762999501168 gnomAD-4.0.0 1.36884E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31981E-05 0
T/S 21008 Fn3-40 46 None 0.079 None 0.003 N 0.311 0.054 0.0482279557977 gnomAD-4.0.0 6.84427E-07 None None None None N None 0 0 None 0 2.52449E-05 None 0 0 0 0 0
K/R 21311 Fn3-42 46 rs375535453 0.1115 None 0.999 N 0.592 0.309 None gnomAD-4.0.0 1.59255E-06 None None None None N None 5.66701E-05 0 None 0 0 None 0 0 0 0 0
D/G 21413 Fn3-43 48 rs375659466 0.184 0.041 0.008 N 0.389 0.21 None gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.34E-05 0
D/G 21413 Fn3-43 48 rs375659466 0.184 0.041 0.008 N 0.389 0.21 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
D/G 21413 Fn3-43 48 rs375659466 0.184 0.041 0.008 N 0.389 0.21 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
D/G 21413 Fn3-43 48 rs375659466 0.184 0.041 0.008 N 0.389 0.21 None gnomAD-4.0.0 4.4011E-05 None None None None N None 0 0 None 0 0 None 0 0 5.76557E-05 0 4.80384E-05
G/D 21605 Fn3-44 47 rs1553632971 0.4533 None 1.0 N 0.631 0.459 0.29527378943 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
L/F 21704 Fn3-45 46 None 0.6148 None 1.0 N 0.612 0.302 0.435699915968 gnomAD-4.0.0 3.42198E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49822E-06 0 0
D/E 21802 Fn3-46 46 rs1228795197 0.131 -0.016 0.005 N 0.145 0.07 0.112648838833 gnomAD-2.1.1 4.1E-06 None None None None N None 0 0 None 0 0 None 3.34E-05 None 0 0 0
D/E 21802 Fn3-46 46 rs1228795197 0.131 -0.016 0.005 N 0.145 0.07 0.112648838833 gnomAD-4.0.0 1.59782E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44259E-05 0
P/L 22001 Fn3-47 46 rs777788378 0.2865 -0.171 0.08 N 0.282 0.266 0.393006254552 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.63E-05 None 0 None 0 0 0
P/L 22001 Fn3-47 46 rs777788378 0.2865 -0.171 0.08 N 0.282 0.266 0.393006254552 gnomAD-4.0.0 6.84554E-07 None None None None N None 0 0 None 0 2.53113E-05 None 0 0 0 0 0
P/R 22001 Fn3-47 46 rs777788378 0.5975 None 0.81 N 0.294 0.351 0.379707525713 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 6.32911E-03 0 0 0
P/R 22001 Fn3-47 46 rs777788378 0.5975 None 0.81 N 0.294 0.351 0.379707525713 gnomAD-4.0.0 1.85998E-06 None None None None N None 0 0 None 0 0 None 0 3.30251E-04 8.47909E-07 0 0
V/L 22100 Fn3-48 46 None 0.109 None None N 0.069 0.042 0.256283259241 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/G 22201 Fn3-49 46 None 0.1378 None 0.505 N 0.513 0.136 0.195762928549 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 22201 Fn3-49 46 rs368924655 0.1086 0.528 0.852 N 0.497 0.21 None gnomAD-2.1.1 2.15E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.7E-05 0
D/N 22201 Fn3-49 46 rs368924655 0.1086 0.528 0.852 N 0.497 0.21 None gnomAD-3.1.2 9.21E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 1.61841E-04 0 0
D/N 22201 Fn3-49 46 rs368924655 0.1086 0.528 0.852 N 0.497 0.21 None gnomAD-4.0.0 3.22449E-05 None None None None N None 4.00203E-05 0 None 0 4.4827E-05 None 0 1.65289E-04 3.90084E-05 0 0
K/E 22399 Fn3-50 46 rs1060500421 0.8074 None 0.999 N 0.616 0.386 0.317084106153 gnomAD-4.0.0 1.59214E-06 None None None None N None 0 2.28676E-05 None 0 0 None 0 0 0 0 0
N/S 22495 Fn3-51 45 None 0.1053 None 0.425 N 0.321 0.136 0.110078149338 gnomAD-4.0.0 2.05318E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69895E-06 0 0
N/D 22689 Fn3-52 47 rs786205382 0.2113 None 0.822 N 0.325 0.288 0.216624796971 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
N/I 22689 Fn3-52 47 None 0.5211 None 0.97 D 0.549 0.489 0.503990602145 gnomAD-4.0.0 6.84412E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15942E-05 0
N/S 22689 Fn3-52 47 rs375397094 0.0999 -0.832 0.822 N 0.331 0.218 None gnomAD-4.0.0 2.05324E-06 None None None None N None 2.99025E-05 0 None 0 0 None 0 0 1.79933E-06 0 0
L/P 22788 Fn3-53 46 rs745626806 0.7429 -0.116 0.975 N 0.659 0.52 0.712016079665 gnomAD-2.1.1 4.44E-05 None None None None I None 0 0 None 0 0 None 0 None 0 9.8E-05 0
L/P 22788 Fn3-53 46 rs745626806 0.7429 -0.116 0.975 N 0.659 0.52 0.712016079665 gnomAD-4.0.0 1.84846E-05 None None None None I None 0 0 None 0 0 None 0 0 2.33942E-05 0 1.65722E-05
L/P 23184 Fn3-56 46 rs1334258779 0.1882 -0.453 0.939 N 0.275 0.287 0.603223074362 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
L/P 23184 Fn3-56 46 rs1334258779 0.1882 -0.453 0.939 N 0.275 0.287 0.603223074362 gnomAD-4.0.0 3.18326E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86582E-05 0
E/G 23285 Fn3-57 46 None 0.104 None 0.22 N 0.502 0.226 0.245660935333 gnomAD-4.0.0 7.56972E-06 None None None None N None 0 0 None 0 0 None 0 0 9.022E-06 0 1.66739E-05
E/K 23285 Fn3-57 46 rs376870149 0.092 0.66 0.613 N 0.549 0.228 None gnomAD-2.1.1 5.93E-05 None None None None N None 3.35008E-04 8.81E-05 None 0 0 None 3.51E-05 None 0 3.24E-05 0
E/K 23285 Fn3-57 46 rs376870149 0.092 0.66 0.613 N 0.549 0.228 None gnomAD-3.1.2 1.97345E-04 None None None None N None 6.27837E-04 6.56E-05 0 0 0 None 0 0 2.94E-05 2.07211E-04 0
E/K 23285 Fn3-57 46 rs376870149 0.092 0.66 0.613 N 0.549 0.228 None 1000 genomes 3.99361E-04 None None None None N None 8E-04 0 None None 0 0 None None None 1E-03 None
E/K 23285 Fn3-57 46 rs376870149 0.092 0.66 0.613 N 0.549 0.228 None gnomAD-4.0.0 6.41997E-05 None None None None N None 4.83637E-04 8.53009E-05 None 0 2.24014E-05 None 0 0 4.93186E-05 2.2412E-05 1.61233E-05
K/Q 23480 Fn3-58 46 None 0.6784 None 0.999 N 0.65 0.252 0.291694819147 gnomAD-4.0.0 1.59177E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85907E-06 0 0
D/N 23577 Fn3-59 46 rs1343180009 0.0856 0.581 0.003 N 0.314 0.118 0.258283824007 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/N 23577 Fn3-59 46 rs1343180009 0.0856 0.581 0.003 N 0.314 0.118 0.258283824007 gnomAD-4.0.0 1.59174E-06 None None None None N None 0 2.28666E-05 None 0 0 None 0 0 0 0 0
I/T 23871 Fn3-61 46 rs770250820 0.8434 -0.553 1.0 N 0.503 0.414 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
I/T 23871 Fn3-61 46 rs770250820 0.8434 -0.553 1.0 N 0.503 0.414 None gnomAD-4.0.0 1.59163E-06 None None None None N None 0 0 None 0 2.77393E-05 None 0 0 0 0 0
L/S 24168 Fn3-63 47 None 0.9114 None 0.988 N 0.534 0.435 0.750485479121 gnomAD-4.0.0 1.9379E-06 None None None None N None 0 0 None 0 0 None 0 0 3.35891E-06 0 0
Q/H 24267 Fn3-64 46 None 0.1948 None 0.526 N 0.201 0.067 0.283371740733 gnomAD-4.0.0 7.14629E-07 None None None None N None 0 0 None 0 0 None 0 0 9.24141E-07 0 0
Q/R 24267 Fn3-64 46 rs1708915937 0.1612 None 0.061 N 0.265 0.105 0.191931220699 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
Q/R 24267 Fn3-64 46 rs1708915937 0.1612 None 0.061 N 0.265 0.105 0.191931220699 gnomAD-4.0.0 6.57333E-06 None None None None N None 0 6.54622E-05 None 0 0 None 0 0 0 0 0
D/H 24368 Fn3-65 46 None 0.233 None 0.999 N 0.72 0.381 0.425028116352 gnomAD-4.0.0 6.84511E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65761E-05
D/N 24368 Fn3-65 46 None 0.084 None 0.998 N 0.688 0.306 0.327952845175 gnomAD-4.0.0 1.36902E-06 None None None None N None 5.98086E-05 0 None 0 0 None 0 0 0 0 0
D/Y 24368 Fn3-65 46 rs886042474 0.204 None 0.998 N 0.741 0.43 0.654079243945 gnomAD-4.0.0 6.84511E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99701E-07 0 0
K/I 24564 Fn3-66 46 rs758888839 0.9656 None 0.995 N 0.672 0.478 0.527251791467 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
K/I 24564 Fn3-66 46 rs758888839 0.9656 None 0.995 N 0.672 0.478 0.527251791467 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/I 24564 Fn3-66 46 rs758888839 0.9656 None 0.995 N 0.672 0.478 0.527251791467 gnomAD-4.0.0 9.92236E-06 None None None None N None 0 0 None 0 0 None 0 0 1.35717E-05 0 0
I/N 24953 Fn3-69 46 rs370142941 0.8654 -0.146 0.942 N 0.572 0.408 0.676505548274 gnomAD-4.0.0 1.36862E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.31879E-05 0
I/T 24953 Fn3-69 46 rs370142941 0.9033 -0.454 0.822 N 0.521 0.219 None gnomAD-2.1.1 4.03E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
I/V 24953 Fn3-69 46 rs1420626943 0.1996 -0.202 0.489 N 0.476 0.075 0.451118754121 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.58E-05 None 0 None 0 0 0
I/V 24953 Fn3-69 46 rs1420626943 0.1996 -0.202 0.489 N 0.476 0.075 0.451118754121 gnomAD-4.0.0 1.5918E-06 None None None None I None 0 0 None 0 2.77577E-05 None 0 0 0 0 0
L/F 25250 Fn3-71 47 rs1231715116 0.6754 -0.54 0.988 N 0.652 0.298 0.437958778045 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
L/F 25250 Fn3-71 47 rs1231715116 0.6754 -0.54 0.988 N 0.652 0.298 0.437958778045 gnomAD-4.0.0 1.59251E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43299E-05 0
I/V 25349 Fn3-72 46 None 0.0813 None 0.012 N 0.167 0.06 0.317667799068 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/D 25450 Fn3-73 46 rs748296171 0.1495 -0.186 0.003 N 0.227 0.228 0.213573922156 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
G/D 25450 Fn3-73 46 rs748296171 0.1495 -0.186 0.003 N 0.227 0.228 0.213573922156 gnomAD-4.0.0 7.52842E-06 None None None None N None 0 0 None 0 0 None 0 3.47343E-04 6.297E-06 1.15969E-05 1.65706E-05
G/S 25450 Fn3-73 46 rs770136413 0.1107 -0.332 0.684 N 0.311 0.243 0.309530620856 gnomAD-2.1.1 4.65E-05 None None None None N None 8.27E-05 0 None 9.68E-05 0 None 2.9431E-04 None 0 0 1.40528E-04
G/S 25450 Fn3-73 46 rs770136413 0.1107 -0.332 0.684 N 0.311 0.243 0.309530620856 gnomAD-3.1.2 2.63E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 2.07469E-04 4.78469E-04
G/S 25450 Fn3-73 46 rs770136413 0.1107 -0.332 0.684 N 0.311 0.243 0.309530620856 gnomAD-4.0.0 1.17787E-05 None None None None N None 2.67208E-05 0 None 3.38066E-05 0 None 0 0 0 1.53762E-04 3.20338E-05
E/K 25743 Fn3-75 46 rs765997807 0.1786 0.665 0.22 N 0.56 0.214 0.273070737957 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
E/K 25743 Fn3-75 46 rs765997807 0.1786 0.665 0.22 N 0.56 0.214 0.273070737957 gnomAD-4.0.0 2.73771E-06 None None None None N None 0 0 None 0 2.5208E-05 None 0 0 1.79923E-06 0 1.65695E-05
E/Q 25743 Fn3-75 46 None 0.1683 None 0.22 N 0.541 0.152 0.265929055128 gnomAD-4.0.0 6.84428E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99614E-07 0 0
T/R 25936 Fn3-76 47 rs533763128 0.5193 0.214 1.0 N 0.596 0.409 0.636471652698 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93498E-04 None 0 0 0 0 0
T/R 25936 Fn3-76 47 rs533763128 0.5193 0.214 1.0 N 0.596 0.409 0.636471652698 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
T/R 25936 Fn3-76 47 rs533763128 0.5193 0.214 1.0 N 0.596 0.409 0.636471652698 gnomAD-4.0.0 6.56996E-06 None None None None N None 0 0 None 0 1.93949E-04 None 0 0 0 0 0
I/V 26035 Fn3-77 46 None 0.2568 None 0.011 N 0.387 0.151 0.446010312102 gnomAD-4.0.0 1.59217E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85964E-06 0 0
G/S 26133 Fn3-78 46 rs1706451609 0.4539 None 1.0 N 0.627 0.494 0.340510301474 gnomAD-4.0.0 1.59379E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86423E-06 0 0
L/I 26332 Fn3-79 47 None 0.2401 None 0.919 N 0.493 0.237 0.365703291355 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/F 26431 Fn3-80 46 None 0.282 None 0.967 N 0.651 0.229 0.516437024119 gnomAD-4.0.0 2.40067E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62503E-06 0 0
I/N 26431 Fn3-80 46 None 0.5296 None 0.994 N 0.668 0.529 0.72833840645 gnomAD-4.0.0 1.59199E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85902E-06 0 0
E/K 26532 Fn3-81 46 rs964829504 0.119 0.633 0.645 N 0.557 0.284 0.315314060047 gnomAD-2.1.1 8.06E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
E/K 26532 Fn3-81 46 rs964829504 0.119 0.633 0.645 N 0.557 0.284 0.315314060047 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
E/K 26532 Fn3-81 46 rs964829504 0.119 0.633 0.645 N 0.557 0.284 0.315314060047 gnomAD-4.0.0 3.09936E-06 None None None None N None 0 5.00384E-05 None 0 0 None 0 3.28839E-04 0 0 0
E/Q 26532 Fn3-81 46 None 0.148 None 0.864 N 0.526 0.285 0.339316883193 gnomAD-4.0.0 6.84392E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99522E-07 0 0
K/E 26728 Fn3-82 46 None 0.9427 None 0.978 N 0.578 0.26 0.30212335484 gnomAD-4.0.0 1.5916E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
T/S 27018 Fn3-84 47 None 0.2218 None 0.958 N 0.425 0.265 0.185906805712 gnomAD-4.0.0 1.59162E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85917E-06 0 0
I/T 27117 Fn3-85 46 rs1326162454 0.9153 -0.344 0.99 N 0.561 0.393 0.615732620514 gnomAD-2.1.1 4.1E-06 None None None None I None 0 0 None 0 0 None 3.29E-05 None 0 0 0
I/T 27117 Fn3-85 46 rs1326162454 0.9153 -0.344 0.99 N 0.561 0.393 0.615732620514 gnomAD-4.0.0 3.19026E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.87183E-05 0
G/S 27215 Fn3-86 46 rs1704934974 0.3529 None 0.992 N 0.542 0.309 0.326616659874 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/S 27215 Fn3-86 46 rs1704934974 0.3529 None 0.992 N 0.542 0.309 0.326616659874 gnomAD-4.0.0 6.57289E-06 None None None None N None 2.41231E-05 0 None 0 0 None 0 0 0 0 0
G/V 27215 Fn3-86 46 None 0.8565 None 0.999 N 0.687 0.369 0.595474516288 gnomAD-4.0.0 2.74013E-06 None None None None N None 0 0 None 0 0 None 0 0 3.60056E-06 0 0
V/F 27514 Fn3-88 46 rs745920301 0.137 -0.531 0.541 N 0.377 0.199 0.224531998449 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/F 27514 Fn3-88 46 rs745920301 0.137 -0.531 0.541 N 0.377 0.199 0.224531998449 gnomAD-4.0.0 6.84211E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
V/I 27514 Fn3-88 46 rs745920301 0.0521 -0.035 None N 0.211 0.148 0.115124310173 gnomAD-2.1.1 1.78E-05 None None None None N None 0 2.83E-05 None 0 0 None 6.54E-05 None 0 1.56E-05 0
V/I 27514 Fn3-88 46 rs745920301 0.0521 -0.035 None N 0.211 0.148 0.115124310173 gnomAD-3.1.2 4.6E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 4.41E-05 4.14594E-04 0
V/I 27514 Fn3-88 46 rs745920301 0.0521 -0.035 None N 0.211 0.148 0.115124310173 gnomAD-4.0.0 2.10689E-05 None None None None N None 3.99936E-05 1.66683E-05 None 0 0 None 0 1.64962E-04 1.35621E-05 1.42738E-04 0
D/H 27615 Fn3-89 46 None 0.2855 None 0.984 N 0.613 0.426 0.330589388543 gnomAD-4.0.0 3.18313E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86558E-05 0
K/N 27811 Fn3-90 46 None 0.9555 None 0.998 N 0.421 0.255 0.270001397563 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 28100 Fn3-92 46 rs779244941 0.2629 0.007 0.994 N 0.563 0.425 0.40528724903 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/I 28100 Fn3-92 46 rs779244941 0.2629 0.007 0.994 N 0.563 0.425 0.40528724903 gnomAD-4.0.0 3.18338E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.8659E-05 0
T/K 28100 Fn3-92 46 None 0.256 None 0.919 N 0.518 0.342 0.351614576976 gnomAD-4.0.0 1.59169E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85856E-06 0 0
G/D 28297 Fn3-94 46 rs1200686560 0.7883 -0.312 0.995 N 0.627 0.486 0.384252928164 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
G/D 28297 Fn3-94 46 rs1200686560 0.7883 -0.312 0.995 N 0.627 0.486 0.384252928164 gnomAD-4.0.0 1.59146E-06 None None None None N None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
G/S 28297 Fn3-94 46 rs780963952 0.2969 -0.313 0.997 D 0.625 0.459 0.343560092441 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
G/S 28297 Fn3-94 46 rs780963952 0.2969 -0.313 0.997 D 0.625 0.459 0.343560092441 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
T/I 28696 Fn3-97 46 None 0.1142 None 0.939 N 0.439 0.202 0.323342291347 gnomAD-4.0.0 6.84249E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99454E-07 0 0
T/N 28696 Fn3-97 46 None 0.0893 None 0.684 N 0.323 0.208 0.236890367714 gnomAD-4.0.0 6.84249E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
K/R 28987 Fn3-99 46 rs1186947794 0.081 0.179 0.012 N 0.385 0.082 0.30212335484 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
K/R 28987 Fn3-99 46 rs1186947794 0.081 0.179 0.012 N 0.385 0.082 0.30212335484 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/R 28987 Fn3-99 46 rs1186947794 0.081 0.179 0.012 N 0.385 0.082 0.30212335484 gnomAD-4.0.0 5.12438E-06 None None None None N None 0 0 None 0 0 None 0 0 7.17851E-06 1.33994E-05 0
A/E 29183 Fn3-100 47 rs747056438 0.5194 0.141 0.638 N 0.447 0.264 None gnomAD-2.1.1 8.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.86E-06 0
A/E 29183 Fn3-100 47 rs747056438 0.5194 0.141 0.638 N 0.447 0.264 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/E 29183 Fn3-100 47 rs747056438 0.5194 0.141 0.638 N 0.447 0.264 None gnomAD-4.0.0 9.29465E-06 None None None None N None 0 1.66644E-05 None 0 0 None 0 0 1.18659E-05 0 0
A/T 29183 Fn3-100 47 None 0.1067 None 0.004 N 0.357 0.095 0.158396225186 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31253E-06 0 0
A/V 29183 Fn3-100 47 None 0.1672 None 0.201 N 0.4 0.212 0.387689773709 gnomAD-4.0.0 6.84166E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99429E-07 0 0
I/V 29282 Fn3-101 46 rs1396385719 0.1752 -0.119 0.008 N 0.229 0.069 0.338834610459 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
G/D 29380 Fn3-102 46 rs1701762557 0.7461 None 0.999 N 0.657 0.377 0.368369118721 gnomAD-4.0.0 1.27307E-05 None None None None N None 0 0 None 0 2.22321E-04 None 0 0 0 0 0
V/A 29579 Fn3-103 47 rs777595903 0.3968 -0.159 0.978 N 0.463 0.308 0.564541561611 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
V/A 29579 Fn3-103 47 rs777595903 0.3968 -0.159 0.978 N 0.463 0.308 0.564541561611 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 29579 Fn3-103 47 rs777595903 0.3968 -0.159 0.978 N 0.463 0.308 0.564541561611 gnomAD-4.0.0 2.56215E-06 None None None None I None 0 0 None 0 0 None 0 0 4.78535E-06 0 0
V/D 29579 Fn3-103 47 None 0.7978 None 0.999 N 0.637 0.529 0.728753902033 gnomAD-4.0.0 1.59102E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8578E-06 0 0
V/F 29579 Fn3-103 47 rs879204059 0.3942 None 0.999 N 0.523 0.291 0.652406804477 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/F 29579 Fn3-103 47 rs879204059 0.3942 None 0.999 N 0.523 0.291 0.652406804477 gnomAD-4.0.0 6.57315E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47003E-05 0 0
V/I 29579 Fn3-103 47 rs879204059 0.0877 None 0.768 N 0.356 0.173 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/I 29579 Fn3-103 47 rs879204059 0.0877 None 0.768 N 0.356 0.173 None gnomAD-4.0.0 9.91472E-06 None None None None I None 1.33497E-05 0 None 0 0 None 0 0 1.27135E-05 0 0
L/P 29678 Fn3-104 46 None 0.1699 None 1.0 N 0.735 0.572 0.706817979235 gnomAD-4.0.0 1.59118E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85804E-06 0 0
E/K 29779 Fn3-105 46 None 0.091 None 0.001 N 0.227 0.073 0.222439326576 gnomAD-4.0.0 1.59116E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02389E-05
R/G 29978 Fn3-106 46 rs746391024 0.6045 -0.194 0.98 N 0.492 0.413 0.266385636622 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
R/G 29978 Fn3-106 46 rs746391024 0.6045 -0.194 0.98 N 0.492 0.413 0.266385636622 gnomAD-4.0.0 6.84609E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99459E-07 0 0
R/K 29978 Fn3-106 46 rs570797774 0.1455 None 0.122 N 0.2 0.136 0.186928172975 gnomAD-4.0.0 1.36925E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79892E-06 0 0
Q/L 30075 Fn3-107 46 rs1439429977 0.0923 0.271 0.27 N 0.409 0.153 0.36355261348 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
Q/L 30075 Fn3-107 46 rs1439429977 0.0923 0.271 0.27 N 0.409 0.153 0.36355261348 gnomAD-4.0.0 4.77315E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.29812E-05 0
I/L 30369 Fn3-109 46 rs768987204 0.1309 -0.175 0.011 N 0.129 0.076 0.259272394797 gnomAD-2.1.1 1.61E-05 None None None None N None 0 1.15888E-04 None 0 0 None 0 None 0 0 0
I/L 30369 Fn3-109 46 rs768987204 0.1309 -0.175 0.011 N 0.129 0.076 0.259272394797 gnomAD-4.0.0 7.95565E-06 None None None None N None 0 1.14317E-04 None 0 0 None 0 0 0 0 0
I/M 30369 Fn3-109 46 None 0.2536 None 0.989 N 0.327 0.192 0.344945010812 gnomAD-4.0.0 2.05258E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69835E-06 0 0
I/V 30369 Fn3-109 46 rs768987204 0.1558 None 0.689 N 0.213 0.078 0.420199648628 gnomAD-4.0.0 1.59113E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85796E-06 0 0
L/P 30665 Fn3-111 47 rs1412840625 0.6581 None 0.995 N 0.553 0.557 0.818544703288 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/P 30665 Fn3-111 47 rs1412840625 0.6581 None 0.995 N 0.553 0.557 0.818544703288 gnomAD-4.0.0 6.57177E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46981E-05 0 0
T/K 30764 Fn3-112 46 rs376537509 0.2413 0.09 0.175 N 0.333 0.167 None gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.55E-05 0
T/K 30764 Fn3-112 46 rs376537509 0.2413 0.09 0.175 N 0.333 0.167 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
T/K 30764 Fn3-112 46 rs376537509 0.2413 0.09 0.175 N 0.333 0.167 None gnomAD-4.0.0 1.92099E-05 None None None None N None 0 0 None 0 0 None 0 0 2.62748E-05 0 0
T/S 30764 Fn3-112 46 None 0.0922 None 0.081 N 0.283 0.091 0.151104730317 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/C 31061 Fn3-114 46 rs768270597 0.4446 -0.219 1.0 N 0.479 0.317 0.659234351692 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 8.92E-06 0
R/C 31061 Fn3-114 46 rs768270597 0.4446 -0.219 1.0 N 0.479 0.317 0.659234351692 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
R/C 31061 Fn3-114 46 rs768270597 0.4446 -0.219 1.0 N 0.479 0.317 0.659234351692 gnomAD-4.0.0 3.71818E-06 None None None None N None 2.67065E-05 0 None 0 2.22826E-05 None 0 0 2.54279E-06 0 0
R/H 31061 Fn3-114 46 rs727504923 0.2893 -0.532 0.999 N 0.506 0.284 None gnomAD-2.1.1 3.58E-05 None None None None N None 2.06714E-04 0 None 0 0 None 0 None 0 3.92E-05 0
R/H 31061 Fn3-114 46 rs727504923 0.2893 -0.532 0.999 N 0.506 0.284 None gnomAD-3.1.2 7.89E-05 None None None None N None 2.41359E-04 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
R/H 31061 Fn3-114 46 rs727504923 0.2893 -0.532 0.999 N 0.506 0.284 None gnomAD-4.0.0 2.66461E-05 None None None None N None 2.26957E-04 3.33356E-05 None 0 0 None 0 0 1.8647E-05 1.09786E-05 1.60102E-05
R/P 31061 Fn3-114 46 rs727504923 0.8489 None 0.998 N 0.493 0.282 0.408172294925 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/P 31061 Fn3-114 46 rs727504923 0.8489 None 0.998 N 0.493 0.282 0.408172294925 gnomAD-4.0.0 6.57246E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47011E-05 0 0
T/I 31354 Fn3-116 47 rs930361700 0.3222 None 0.998 N 0.579 0.364 0.383921772103 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 4.78011E-04
T/I 31354 Fn3-116 47 rs930361700 0.3222 None 0.998 N 0.579 0.364 0.383921772103 gnomAD-4.0.0 3.7181E-06 None None None None N None 5.33832E-05 0 None 0 0 None 0 0 8.47593E-07 0 1.60113E-05
I/F 31453 Fn3-117 46 rs780232811 0.8502 -0.498 1.0 N 0.649 0.411 0.652986081711 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/F 31453 Fn3-117 46 rs780232811 0.8502 -0.498 1.0 N 0.649 0.411 0.652986081711 gnomAD-4.0.0 6.84196E-07 None None None None I None 0 2.23604E-05 None 0 0 None 0 0 0 0 0
I/V 31453 Fn3-117 46 rs780232811 0.3315 None 0.993 N 0.494 0.215 0.511047945453 gnomAD-3.1.2 1.31E-05 None None None None I None 0 1.30907E-04 0 0 0 None 0 0 0 0 0
I/V 31453 Fn3-117 46 rs780232811 0.3315 None 0.993 N 0.494 0.215 0.511047945453 gnomAD-4.0.0 4.33778E-06 None None None None I None 0 5E-05 None 0 0 None 0 0 3.39042E-06 0 0
G/S 31554 Fn3-118 49 None 0.1165 None 0.956 N 0.542 0.316 0.286465849087 gnomAD-4.0.0 4.78953E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29642E-06 0 0
L/P 31852 Fn3-120 46 rs62621206 0.2839 -0.064 0.896 N 0.319 0.2 None gnomAD-2.1.1 1.08384E-02 None None None None I None 3.01853E-03 5.59765E-03 None 9.08564E-03 0 None 2.64689E-03 None 1.23891E-02 1.70026E-02 1.4446E-02
L/P 31852 Fn3-120 46 rs62621206 0.2839 -0.064 0.896 N 0.319 0.2 None gnomAD-3.1.2 1.12135E-02 None None None None I None 3.13707E-03 1.1261E-02 3.95604E-02 1.18088E-02 0 None 1.03715E-02 0 1.72738E-02 2.28311E-03 1.48325E-02
L/P 31852 Fn3-120 46 rs62621206 0.2839 -0.064 0.896 N 0.319 0.2 None 1000 genomes 5.59105E-03 None None None None I None 8E-04 8.6E-03 None None 0 1.99E-02 None None None 1E-03 None
L/P 31852 Fn3-120 46 rs62621206 0.2839 -0.064 0.896 N 0.319 0.2 None gnomAD-4.0.0 1.51072E-02 None None None None I None 2.85227E-03 8.09838E-03 None 9.62903E-03 4.45732E-05 None 1.25922E-02 1.37054E-02 1.80035E-02 2.81102E-03 1.5559E-02
L/Q 31852 Fn3-120 46 None 0.1847 -0.05 0.81 N 0.304 0.18 0.40146981186 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
L/Q 31852 Fn3-120 46 None 0.1847 -0.05 0.81 N 0.304 0.18 0.40146981186 gnomAD-4.0.0 1.36847E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99523E-07 1.15934E-05 0
L/R 31852 Fn3-120 46 rs62621206 0.3253 0.315 0.81 N 0.311 0.204 0.372087925617 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/E 31954 Fn3-121 46 rs765845110 0.0801 0.05 0.001 N 0.077 0.077 0.0716867268079 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
R/T 32150 Fn3-122 46 None 0.8349 None 0.98 N 0.53 0.316 0.336155897331 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 32247 Fn3-123 46 None 0.2252 None 0.896 N 0.355 0.287 0.300449992093 gnomAD-4.0.0 3.18231E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86549E-05 0
E/Q 32247 Fn3-123 46 rs1695477466 0.1795 None 0.946 N 0.319 0.243 0.328752806141 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
E/Q 32247 Fn3-123 46 rs1695477466 0.1795 None 0.946 N 0.319 0.243 0.328752806141 gnomAD-4.0.0 6.57557E-06 None None None None N None 0 6.5591E-05 None 0 0 None 0 0 0 0 0
P/L 32445 Fn3-124 47 rs1330389316 0.4552 -0.004 1.0 N 0.673 0.441 0.59105502098 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
P/L 32445 Fn3-124 47 rs1330389316 0.4552 -0.004 1.0 N 0.673 0.441 0.59105502098 gnomAD-4.0.0 1.59154E-06 None None None None N None 0 0 None 0 2.77608E-05 None 0 0 0 0 0
A/T 32841 Fn3-127 47 None 0.1048 None None N 0.181 0.043 0.167679373172 gnomAD-4.0.0 6.84185E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99462E-07 0 0
D/E 32942 Fn3-128 47 rs190967471 0.1089 -0.016 0.006 N 0.333 0.109 0.107399877778 gnomAD-2.1.1 9.28E-05 None None None None N None 9.92063E-04 2.83E-05 None 0 0 None 0 None 0 7.81E-06 0
D/E 32942 Fn3-128 47 rs190967471 0.1089 -0.016 0.006 N 0.333 0.109 0.107399877778 gnomAD-3.1.2 1.97231E-04 None None None None N None 6.75937E-04 1.31027E-04 0 0 0 None 0 0 0 0 0
D/E 32942 Fn3-128 47 rs190967471 0.1089 -0.016 0.006 N 0.333 0.109 0.107399877778 1000 genomes 3.99361E-04 None None None None N None 1.5E-03 0 None None 0 0 None None None 0 None
D/E 32942 Fn3-128 47 rs190967471 0.1089 -0.016 0.006 N 0.333 0.109 0.107399877778 gnomAD-4.0.0 3.59412E-05 None None None None N None 6.53298E-04 8.33333E-05 None 0 0 None 0 0 1.69528E-06 0 3.20113E-05
D/N 32942 Fn3-128 47 None 0.1374 None 0.822 N 0.551 0.24 0.209622950755 gnomAD-4.0.0 3.18261E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71693E-06 0 0
S/G 33043 Fn3-129 46 None 0.0911 None 0.896 N 0.638 0.135 0.200317383148 gnomAD-4.0.0 2.73688E-06 None None None None N None 0 4.47227E-05 None 0 0 None 0 0 1.79899E-06 0 0
N/S 33437 Fn3-131 46 rs1691532335 0.1198 None 0.925 N 0.537 0.22 0.176091768786 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
N/S 33437 Fn3-131 46 rs1691532335 0.1198 None 0.925 N 0.537 0.22 0.176091768786 gnomAD-4.0.0 8.98166E-06 None None None None N None 3.38868E-05 0 None 0 0 None 0 1.12309E-03 0 0 0
E/Q 33734 Fn3-132 46 None 0.3951 None 0.922 N 0.501 0.233 0.195762928549 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.