Structural position:

  • Domain Type: Fn3
  • Aligned Position: 70
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand C'

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
D/V 15709 Fn3-1 53 None 0.7315 None 0.999 N 0.831 0.479 0.433713641954 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
T/I 15810 Fn3-2 53 rs748816848 0.1427 0.083 0.012 N 0.276 0.143 None gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 9.8E-05 None 0 8.91E-06 0
T/I 15810 Fn3-2 53 rs748816848 0.1427 0.083 0.012 N 0.276 0.143 None gnomAD-4.0.0 1.09536E-05 None None None None N None 0 0 None 0 0 None 0 0 3.59969E-06 1.27563E-04 1.65854E-05
T/P 15810 Fn3-2 53 None 0.2468 None 0.989 N 0.578 0.371 0.393927044628 gnomAD-4.0.0 1.36919E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31927E-05 0
T/S 15810 Fn3-2 53 None 0.1277 None 0.891 N 0.366 0.116 0.183819452728 gnomAD-4.0.0 6.84598E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99922E-07 0 0
M/T 15911 Fn3-3 53 rs761390938 0.126 0.127 None N 0.197 0.185 0.194818534648 gnomAD-2.1.1 2.36E-05 None None None None I None 0 3.69E-05 None 0 0 None 0 None 0 4.12E-05 0
M/T 15911 Fn3-3 53 rs761390938 0.126 0.127 None N 0.197 0.185 0.194818534648 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/T 15911 Fn3-3 53 rs761390938 0.126 0.127 None N 0.197 0.185 0.194818534648 gnomAD-4.0.0 5.68789E-06 None None None None I None 0 3.79305E-05 None 0 0 None 0 0 5.99391E-06 0 0
D/G 16107 Fn3-4 53 rs775805942 0.2401 None 0.801 N 0.307 0.195 0.236278675362 gnomAD-3.1.2 1.98E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 2.95E-05 0 0
D/G 16107 Fn3-4 53 rs775805942 0.2401 None 0.801 N 0.307 0.195 0.236278675362 gnomAD-4.0.0 2.79629E-05 None None None None N None 1.34027E-05 0 None 0 0 None 0 0 3.48047E-05 0 4.82021E-05
E/Q 16207 Fn3-5 53 rs1372711773 0.1367 0.388 0.722 N 0.511 0.195 0.306377322295 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
E/Q 16207 Fn3-5 53 rs1372711773 0.1367 0.388 0.722 N 0.511 0.195 0.306377322295 gnomAD-4.0.0 3.18884E-06 None None None None N None 0 0 None 0 2.78319E-05 None 0 0 0 0 3.03196E-05
S/P 16403 Fn3-6 53 rs746009199 0.4658 -0.249 1.0 N 0.777 0.458 None gnomAD-2.1.1 4.04E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
S/P 16403 Fn3-6 53 rs746009199 0.4658 -0.249 1.0 N 0.777 0.458 None gnomAD-3.1.2 2.64E-05 None None None None N None 9.67E-05 0 0 0 0 None 0 0 0 0 0
S/P 16403 Fn3-6 53 rs746009199 0.4658 -0.249 1.0 N 0.777 0.458 None gnomAD-4.0.0 6.4169E-06 None None None None N None 8.47716E-05 0 None 0 0 None 0 0 0 0 0
S/T 16403 Fn3-6 53 rs746009199 0.1654 0.049 0.999 N 0.433 0.262 0.263612267334 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
S/Y 16403 Fn3-6 53 rs774691242 0.5218 -0.651 1.0 N 0.804 0.445 0.554841954621 gnomAD-2.1.1 1.08E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.57E-05 1.41004E-04
S/Y 16403 Fn3-6 53 rs774691242 0.5218 -0.651 1.0 N 0.804 0.445 0.554841954621 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/Y 16403 Fn3-6 53 rs774691242 0.5218 -0.651 1.0 N 0.804 0.445 0.554841954621 gnomAD-4.0.0 6.41682E-06 None None None None N None 0 0 None 0 0 None 1.57045E-05 0 9.58529E-06 0 0
K/N 16502 Fn3-7 53 None 0.9735 None 1.0 N 0.683 0.309 0.190952846119 gnomAD-4.0.0 1.59414E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.03067E-05
K/Q 16502 Fn3-7 53 None 0.8038 None 1.0 N 0.681 0.369 0.236278675362 gnomAD-4.0.0 1.59412E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.0303E-05
T/A 16703 Fn3-9 53 rs778518712 0.285 -0.512 0.999 N 0.499 0.377 0.207176502487 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
T/A 16703 Fn3-9 53 rs778518712 0.285 -0.512 0.999 N 0.499 0.377 0.207176502487 gnomAD-4.0.0 1.59387E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86202E-06 0 0
T/I 16703 Fn3-9 53 rs757138357 0.6455 -0.13 1.0 D 0.757 0.415 0.448099371145 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.97E-06 0
T/I 16703 Fn3-9 53 rs757138357 0.6455 -0.13 1.0 D 0.757 0.415 0.448099371145 gnomAD-4.0.0 1.59408E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8622E-06 0 0
T/N 16703 Fn3-9 53 rs757138357 0.4102 -0.006 1.0 N 0.701 0.376 0.388334884743 gnomAD-4.0.0 3.18816E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8622E-06 1.43345E-05 0
K/N 16803 Fn3-10 53 None 0.7849 None 0.993 N 0.701 0.318 0.282575091529 gnomAD-4.0.0 6.84645E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99831E-07 0 0
S/P 16904 Fn3-11 53 None 0.1901 None 1.0 N 0.727 0.435 0.392395365052 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/P 17423 Fn3-14 55 None 0.5367 None 0.317 D 0.343 0.203 0.262175524916 gnomAD-4.0.0 1.59378E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86207E-06 0 0
K/E 17521 Fn3-15 52 rs794729456 0.4689 0.128 0.027 N 0.342 0.072 0.173771789658 gnomAD-2.1.1 4.05E-06 None None None None N None 6.49E-05 0 None 0 0 None 0 None 0 0 0
K/E 17521 Fn3-15 52 rs794729456 0.4689 0.128 0.027 N 0.342 0.072 0.173771789658 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/E 17521 Fn3-15 52 rs794729456 0.4689 0.128 0.027 N 0.342 0.072 0.173771789658 gnomAD-4.0.0 2.56658E-06 None None None None N None 3.38719E-05 0 None 0 0 None 0 0 0 0 0
K/R 17521 Fn3-15 52 None 0.064 None None N 0.189 0.092 0.202086224978 gnomAD-4.0.0 3.42372E-06 None None None None N None 0 0 None 0 2.53537E-05 None 0 1.73732E-04 2.69965E-06 0 0
E/K 17621 Fn3-16 53 None 0.2049 None 0.896 N 0.484 0.299 0.313518423057 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/Q 17621 Fn3-16 53 None 0.1841 None 0.984 N 0.451 0.328 0.254244900254 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 3.66327E-05
E/G 17816 Fn3-17 53 None 0.4841 None 0.645 N 0.603 0.356 0.402043589563 gnomAD-4.0.0 2.05356E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69941E-06 0 0
E/V 17816 Fn3-17 53 None 0.2921 None 0.928 N 0.706 0.487 0.587119504466 gnomAD-4.0.0 6.84519E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16007E-05 0
K/T 17914 Fn3-18 53 None 0.1056 None None N 0.17 0.114 0.0551355673512 gnomAD-4.0.0 2.76429E-06 None None None None N None 0 0 None 0 2.56753E-05 None 1.98523E-05 0 1.81267E-06 0 0
N/K 18119 Fn3-19 55 None 0.2104 None 0.026 N 0.154 0.133 0.112648838833 gnomAD-4.0.0 3.601E-06 None None None None N None 0 0 None 0 0 None 0 0 3.93753E-06 0 0
R/Q 18218 Fn3-20 53 rs143643360 0.4992 0.171 0.993 N 0.601 0.31 None gnomAD-2.1.1 1.79E-05 None None None None I None 4.14E-05 0 None 0 0 None 0 None 0 3.13E-05 0
R/Q 18218 Fn3-20 53 rs143643360 0.4992 0.171 0.993 N 0.601 0.31 None gnomAD-3.1.2 1.32E-05 None None None None I None 2.42E-05 0 0 0 0 None 9.42E-05 0 0 0 0
R/Q 18218 Fn3-20 53 rs143643360 0.4992 0.171 0.993 N 0.601 0.31 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
R/Q 18218 Fn3-20 53 rs143643360 0.4992 0.171 0.993 N 0.601 0.31 None gnomAD-4.0.0 2.728E-05 None None None None I None 4.0032E-05 0 None 0 0 None 3.12422E-05 1.65344E-04 3.22252E-05 0 0
E/Q 18324 Fn3-21 53 None 0.1237 None 0.98 N 0.431 0.208 0.297031009988 gnomAD-4.0.0 1.59372E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43361E-05 0
P/T 18531 Fn3-22 53 None 0.0907 None 0.01 N 0.177 0.136 0.199424873507 gnomAD-4.0.0 3.60097E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 2.625E-06 0 0
S/G 18837 Fn3-24 54 None 0.0926 None 0.09 N 0.263 0.076 0.18995819373 gnomAD-4.0.0 1.37886E-06 None None None None N None 3.04488E-05 0 None 0 0 None 0 0 0 1.19654E-05 0
R/Q 18936 Fn3-25 53 rs745914315 0.2945 0.206 0.999 N 0.546 0.341 0.228597637076 gnomAD-2.1.1 3.58E-05 None None None None I None 0 0 None 0 0 None 0 None 0 7.85E-05 0
R/Q 18936 Fn3-25 53 rs745914315 0.2945 0.206 0.999 N 0.546 0.341 0.228597637076 gnomAD-3.1.2 1.97E-05 None None None None I None 0 6.56E-05 0 0 0 None 0 0 2.94E-05 0 0
R/Q 18936 Fn3-25 53 rs745914315 0.2945 0.206 0.999 N 0.546 0.341 0.228597637076 gnomAD-4.0.0 2.47986E-05 None None None None I None 1.33661E-05 1.66884E-05 None 0 4.47247E-05 None 0 0 3.05218E-05 0 0
Y/H 19236 Fn3-27 54 rs375797796 0.2917 0.517 0.859 N 0.545 0.318 0.359557344763 gnomAD-2.1.1 8.35E-06 None None None None N None 6.78E-05 2.98E-05 None 0 0 None 0 None 0 0 0
Y/H 19236 Fn3-27 54 rs375797796 0.2917 0.517 0.859 N 0.545 0.318 0.359557344763 gnomAD-3.1.2 3.29E-05 None None None None N None 1.20773E-04 0 0 0 0 None 0 0 0 0 0
Y/H 19236 Fn3-27 54 rs375797796 0.2917 0.517 0.859 N 0.545 0.318 0.359557344763 gnomAD-4.0.0 4.35479E-06 None None None None N None 6.68235E-05 1.68862E-05 None 0 0 None 0 0 8.49681E-07 0 0
N/I 19336 Fn3-28 53 rs371851242 0.1627 0.21 0.033 N 0.422 0.045 None gnomAD-2.1.1 3.21E-05 None None None None N None 0 1.1327E-04 None 0 0 None 0 None 0 3.9E-05 0
N/I 19336 Fn3-28 53 rs371851242 0.1627 0.21 0.033 N 0.422 0.045 None gnomAD-3.1.2 4.6E-05 None None None None N None 0 1.96696E-04 0 0 0 None 0 0 5.88E-05 0 0
N/I 19336 Fn3-28 53 rs371851242 0.1627 0.21 0.033 N 0.422 0.045 None gnomAD-4.0.0 5.82666E-05 None None None None N None 0 1.33462E-04 None 0 0 None 0 0 7.2061E-05 0 1.60128E-05
K/R 19630 Fn3-30 52 None 0.0728 None None N 0.125 0.091 0.242244723065 gnomAD-4.0.0 1.59197E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85953E-06 0 0
K/T 19630 Fn3-30 52 rs534551882 0.3987 -0.404 0.22 N 0.6 0.142 0.303453137403 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/T 19630 Fn3-30 52 rs534551882 0.3987 -0.404 0.22 N 0.6 0.142 0.303453137403 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07469E-04 0
K/T 19630 Fn3-30 52 rs534551882 0.3987 -0.404 0.22 N 0.6 0.142 0.303453137403 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
K/T 19630 Fn3-30 52 rs534551882 0.3987 -0.404 0.22 N 0.6 0.142 0.303453137403 gnomAD-4.0.0 6.57376E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07641E-04 0
A/V 19929 Fn3-32 53 rs777824631 0.0918 0.239 0.012 N 0.221 0.166 0.229924730088 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/D 20916 Fn3-39 53 None 0.5199 None 0.331 N 0.544 0.294 0.580281640613 gnomAD-4.0.0 1.59497E-06 None None None None N None 0 0 None 0 0 None 1.90266E-05 0 0 0 0
A/S 20916 Fn3-39 53 None 0.0779 None None N 0.147 0.059 0.238705975628 gnomAD-4.0.0 1.595E-06 None None None None N None 0 0 None 0 2.79408E-05 None 0 0 0 0 0
A/G 21612 Fn3-44 54 rs535324559 0.1732 -0.32 0.454 N 0.353 0.227 0.275641507738 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
A/G 21612 Fn3-44 54 rs535324559 0.1732 -0.32 0.454 N 0.353 0.227 0.275641507738 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.94401E-04 None 0 0 0 0 0
A/G 21612 Fn3-44 54 rs535324559 0.1732 -0.32 0.454 N 0.353 0.227 0.275641507738 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
A/G 21612 Fn3-44 54 rs535324559 0.1732 -0.32 0.454 N 0.353 0.227 0.275641507738 gnomAD-4.0.0 6.57445E-06 None None None None I None 0 0 None 0 1.94856E-04 None 0 0 0 0 0
A/V 21612 Fn3-44 54 rs535324559 0.2605 0.047 0.051 N 0.243 0.162 0.322510055762 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
A/V 21612 Fn3-44 54 rs535324559 0.2605 0.047 0.051 N 0.243 0.162 0.322510055762 gnomAD-4.0.0 1.5919E-06 None None None None I None 0 2.28686E-05 None 0 0 None 0 0 0 0 0
D/A 21711 Fn3-45 53 None 0.3271 None 0.978 N 0.49 0.406 0.404733080969 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 21809 Fn3-46 53 rs756088419 0.1569 0.141 0.782 N 0.403 0.32 0.357724736475 gnomAD-2.1.1 8.14E-06 None None None None I None 0 2.92E-05 None 0 5.7E-05 None 0 None 0 0 0
T/I 21809 Fn3-46 53 rs756088419 0.1569 0.141 0.782 N 0.403 0.32 0.357724736475 gnomAD-4.0.0 1.37023E-06 None None None None I None 0 2.24336E-05 None 0 2.53768E-05 None 0 0 0 0 0
T/N 21809 Fn3-46 53 None 0.1032 None 0.642 N 0.411 0.231 0.296329037015 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/N 21809 Fn3-46 53 None 0.1032 None 0.642 N 0.411 0.231 0.296329037015 gnomAD-4.0.0 1.86144E-06 None None None None I None 0 0 None 0 0 None 0 0 2.54471E-06 0 0
T/S 21809 Fn3-46 53 rs756088419 0.0872 -0.144 0.003 N 0.119 0.076 0.144782658237 gnomAD-2.1.1 4.07E-06 None None None None I None 0 0 None 0 5.7E-05 None 0 None 0 0 0
T/S 21809 Fn3-46 53 rs756088419 0.0872 -0.144 0.003 N 0.119 0.076 0.144782658237 gnomAD-4.0.0 1.37023E-06 None None None None I None 0 0 None 0 2.53768E-05 None 0 0 9.00142E-07 0 0
A/E 22008 Fn3-47 53 rs751787608 0.5212 -0.677 0.331 N 0.505 0.307 0.342400092842 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
A/E 22008 Fn3-47 53 rs751787608 0.5212 -0.677 0.331 N 0.505 0.307 0.342400092842 gnomAD-4.0.0 1.36911E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.3197E-05 0
A/V 22008 Fn3-47 53 rs751787608 0.2219 -0.131 0.22 N 0.488 0.272 0.299086750705 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
A/V 22008 Fn3-47 53 rs751787608 0.2219 -0.131 0.22 N 0.488 0.272 0.299086750705 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
A/V 22008 Fn3-47 53 rs751787608 0.2219 -0.131 0.22 N 0.488 0.272 0.299086750705 gnomAD-4.0.0 1.17804E-05 None None None None N None 0 0 None 0 0 None 0 0 1.611E-05 0 0
R/K 22107 Fn3-48 53 rs548035555 0.2331 0.22 0.025 N 0.37 0.185 0.190952846119 gnomAD-2.1.1 7.15E-06 None None None None I None 8.28E-05 0 None 0 0 None 0 None 0 0 0
R/K 22107 Fn3-48 53 rs548035555 0.2331 0.22 0.025 N 0.37 0.185 0.190952846119 gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
R/K 22107 Fn3-48 53 rs548035555 0.2331 0.22 0.025 N 0.37 0.185 0.190952846119 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
R/K 22107 Fn3-48 53 rs548035555 0.2331 0.22 0.025 N 0.37 0.185 0.190952846119 gnomAD-4.0.0 5.12673E-06 None None None None I None 5.06825E-05 0 None 0 0 None 0 0 2.39462E-06 0 0
T/N 22406 Fn3-50 53 rs766588174 0.1559 -0.053 0.015 N 0.213 0.145 0.201204373187 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/N 22406 Fn3-50 53 rs766588174 0.1559 -0.053 0.015 N 0.213 0.145 0.201204373187 gnomAD-4.0.0 1.59217E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43299E-05 0
K/N 22502 Fn3-51 52 None 0.3284 None 0.722 N 0.582 0.123 0.0920862733494 gnomAD-4.0.0 1.59224E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86015E-06 0 0
S/L 22696 Fn3-52 54 rs1245154926 0.2651 -0.05 0.967 N 0.615 0.478 0.558264529485 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/L 22696 Fn3-52 54 rs1245154926 0.2651 -0.05 0.967 N 0.615 0.478 0.558264529485 gnomAD-4.0.0 1.59226E-06 None None None None N None 0 2.2876E-05 None 0 0 None 0 0 0 0 0
S/P 22696 Fn3-52 54 rs754821175 0.644 -0.165 0.025 N 0.293 0.331 0.223847106136 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
S/P 22696 Fn3-52 54 rs754821175 0.644 -0.165 0.025 N 0.293 0.331 0.223847106136 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/P 22696 Fn3-52 54 rs754821175 0.644 -0.165 0.025 N 0.293 0.331 0.223847106136 gnomAD-4.0.0 2.56398E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78907E-06 0 0
K/R 22795 Fn3-53 53 rs1311571163 0.09 0.423 0.969 N 0.48 0.196 0.258779203287 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/R 22795 Fn3-53 53 rs1311571163 0.09 0.423 0.969 N 0.48 0.196 0.258779203287 gnomAD-4.0.0 1.59261E-06 None None None None I None 0 2.28707E-05 None 0 0 None 0 0 0 0 0
H/D 22893 Fn3-54 53 rs2046760541 0.2848 None 0.822 N 0.449 0.331 0.332386209738 gnomAD-4.0.0 1.36877E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79922E-06 0 0
H/R 22893 Fn3-54 53 rs1039583705 0.171 None 0.942 N 0.433 0.297 None gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.94E-06 0
H/R 22893 Fn3-54 53 rs1039583705 0.171 None 0.942 N 0.433 0.297 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
H/R 22893 Fn3-54 53 rs1039583705 0.171 None 0.942 N 0.433 0.297 None gnomAD-4.0.0 3.09923E-06 None None None None I None 1.33483E-05 0 None 0 0 None 0 0 3.39101E-06 0 0
H/Y 22893 Fn3-54 53 None 0.1076 None 0.966 N 0.453 0.334 0.302459207581 gnomAD-4.0.0 6.84387E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.65711E-05
K/R 23191 Fn3-56 53 None 0.0871 None 0.999 N 0.556 0.291 0.391156786388 gnomAD-4.0.0 9.57988E-06 None None None None N None 0 0 None 0 0 None 0 0 1.2594E-05 0 0
T/R 23292 Fn3-57 53 rs1710041063 0.1565 None 0.879 N 0.407 0.343 0.330331372229 gnomAD-4.0.0 1.59613E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86428E-06 0 0
T/I 23487 Fn3-58 53 None 0.383 None 0.983 N 0.76 0.355 0.39162414616 gnomAD-4.0.0 2.73715E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69865E-06 1.15947E-05 0
T/S 23487 Fn3-58 53 None 0.1392 None 0.008 N 0.307 0.124 0.124217242631 gnomAD-4.0.0 6.84287E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99549E-07 0 0
T/A 23584 Fn3-59 53 rs765545404 0.1052 -0.385 0.022 N 0.52 0.104 0.206339911435 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/A 23584 Fn3-59 53 rs765545404 0.1052 -0.385 0.022 N 0.52 0.104 0.206339911435 gnomAD-4.0.0 3.18344E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.86574E-05 0
T/I 23584 Fn3-59 53 rs1444861045 0.2378 None 0.917 N 0.697 0.431 0.406257615169 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 23584 Fn3-59 53 rs1444861045 0.2378 None 0.917 N 0.697 0.431 0.406257615169 gnomAD-4.0.0 6.57479E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47067E-05 0 0
T/I 23779 Fn3-60 54 rs1709480973 0.4368 None 0.549 N 0.357 0.18 0.245660935333 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 23779 Fn3-60 54 rs1709480973 0.4368 None 0.549 N 0.357 0.18 0.245660935333 gnomAD-4.0.0 4.34229E-06 None None None None N None 0 0 None 0 0 None 0 0 5.93807E-06 0 0
T/P 23779 Fn3-60 54 rs1575793122 0.123 None 0.712 N 0.348 0.207 0.241078983079 gnomAD-4.0.0 1.30136E-05 None None None None N None 0 0 None 0 0 None 0 0 1.71038E-05 0 0
P/L 24375 Fn3-65 53 rs376041680 0.161 -0.606 1.0 N 0.787 0.427 None gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
P/L 24375 Fn3-65 53 rs376041680 0.161 -0.606 1.0 N 0.787 0.427 None gnomAD-4.0.0 3.62785E-05 None None None None N None 0 0 None 0 0 None 0 0 4.49848E-05 0 4.9715E-05
P/T 24375 Fn3-65 53 None 0.1503 None 1.0 N 0.785 0.344 0.499409231958 gnomAD-4.0.0 1.59281E-06 None None None None N None 0 0 None 0 2.78676E-05 None 0 0 0 0 0
T/A 24571 Fn3-66 53 rs752184535 0.0709 -0.494 None N 0.145 0.107 0.117506650769 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/A 24571 Fn3-66 53 rs752184535 0.0709 -0.494 None N 0.145 0.107 0.117506650769 gnomAD-4.0.0 1.59322E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8628E-06 0 0
T/I 24571 Fn3-66 53 None 0.2992 None 0.441 N 0.498 0.39 0.384919354899 gnomAD-4.0.0 4.77992E-06 None None None None N None 0 0 None 0 0 None 0 0 8.58915E-06 0 0
T/I 24668 Fn3-67 53 rs771515164 0.1285 0.199 0.665 N 0.609 0.184 0.294918367191 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.94E-06 0
T/I 24668 Fn3-67 53 rs771515164 0.1285 0.199 0.665 N 0.609 0.184 0.294918367191 gnomAD-4.0.0 6.84429E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99624E-07 0 0
T/R 24668 Fn3-67 53 None 0.1633 None 0.949 N 0.701 0.356 0.355034743287 gnomAD-4.0.0 6.84429E-07 None None None None I None 0 0 None 0 2.52845E-05 None 0 0 0 0 0
A/P 24861 Fn3-68 54 rs879142245 0.7068 -0.15 0.999 N 0.771 0.383 None gnomAD-2.1.1 3.19E-05 None None None None I None 1.14732E-04 0 None 0 0 None 0 None 0 0 0
A/P 24861 Fn3-68 54 rs879142245 0.7068 -0.15 0.999 N 0.771 0.383 None gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/P 24861 Fn3-68 54 rs879142245 0.7068 -0.15 0.999 N 0.771 0.383 None gnomAD-4.0.0 7.43891E-06 None None None None I None 1.33533E-05 0 None 0 0 None 0 0 9.32529E-06 0 0
A/V 24861 Fn3-68 54 rs149232991 0.5105 -0.042 0.998 N 0.665 0.268 None gnomAD-2.1.1 2.02E-05 None None None None I None 3.23457E-04 0 None 0 0 None 0 None 0 0 0
A/V 24861 Fn3-68 54 rs149232991 0.5105 -0.042 0.998 N 0.665 0.268 None gnomAD-3.1.2 5.26E-05 None None None None I None 1.93209E-04 0 0 0 0 None 0 0 0 0 0
A/V 24861 Fn3-68 54 rs149232991 0.5105 -0.042 0.998 N 0.665 0.268 None 1000 genomes 3.99361E-04 None None None None I None 1.5E-03 0 None None 0 0 None None None 0 None
A/V 24861 Fn3-68 54 rs149232991 0.5105 -0.042 0.998 N 0.665 0.268 None gnomAD-4.0.0 1.23975E-05 None None None None I None 2.66745E-04 0 None 0 0 None 0 0 0 0 0
A/G 25257 Fn3-71 54 None 0.0964 None 0.042 N 0.28 0.102 0.224531998449 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/T 25356 Fn3-72 53 rs765495476 0.8653 None 0.988 N 0.649 0.309 0.353336612579 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/S 25457 Fn3-73 53 None 0.1399 None 0.414 N 0.334 0.366 0.327686398923 gnomAD-4.0.0 1.59254E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85927E-06 0 0
R/P 25750 Fn3-75 53 rs368038362 0.6024 -0.157 0.832 N 0.497 0.315 0.317958651998 gnomAD-2.1.1 7.15E-06 None None None None N None 0 0 None 0 0 None 0 None 4.03E-05 7.81E-06 0
R/P 25750 Fn3-75 53 rs368038362 0.6024 -0.157 0.832 N 0.497 0.315 0.317958651998 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/P 25750 Fn3-75 53 rs368038362 0.6024 -0.157 0.832 N 0.497 0.315 0.317958651998 gnomAD-4.0.0 1.8599E-06 None None None None N None 0 0 None 0 0 None 1.56927E-05 0 1.69556E-06 0 0
R/Q 25750 Fn3-75 53 rs368038362 0.0842 0.01 0.175 N 0.207 0.057 None gnomAD-2.1.1 1.14375E-04 None None None None N None 8.27E-05 2.83E-05 None 9.68E-05 0 None 0 None 0 1.95334E-04 4.22297E-04
R/Q 25750 Fn3-75 53 rs368038362 0.0842 0.01 0.175 N 0.207 0.057 None gnomAD-3.1.2 7.23E-05 None None None None N None 7.24E-05 6.56E-05 0 0 0 None 0 0 1.02984E-04 0 0
R/Q 25750 Fn3-75 53 rs368038362 0.0842 0.01 0.175 N 0.207 0.057 None gnomAD-4.0.0 1.10974E-04 None None None None N None 5.34245E-05 3.33589E-05 None 3.38066E-05 0 None 0 1.64636E-04 1.38188E-04 3.2946E-05 8.00846E-05
K/T 26042 Fn3-77 53 rs1261267302 0.4156 -0.023 1.0 N 0.688 0.582 0.400033932507 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
K/T 26042 Fn3-77 53 rs1261267302 0.4156 -0.023 1.0 N 0.688 0.582 0.400033932507 gnomAD-4.0.0 5.4749E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19687E-06 0 0
S/L 26339 Fn3-79 54 None 0.1231 None 0.193 N 0.273 0.184 0.42069145522 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
S/G 26735 Fn3-82 53 None 0.0698 None 0.012 N 0.208 0.106 0.104622674875 gnomAD-4.0.0 6.84271E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99549E-07 0 0
E/K 26832 Fn3-83 53 rs780512337 0.1583 0.932 0.669 N 0.433 0.254 0.243398259712 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.67E-05 0
E/K 26832 Fn3-83 53 rs780512337 0.1583 0.932 0.669 N 0.433 0.254 0.243398259712 gnomAD-4.0.0 4.77482E-06 None None None None I None 0 0 None 0 0 None 0 0 8.57741E-06 0 0
A/P 27025 Fn3-84 54 None 0.5425 None 1.0 N 0.779 0.384 0.372087925617 gnomAD-4.0.0 1.59158E-06 None None None None I None 0 0 None 4.76781E-05 0 None 0 0 0 0 0
K/N 27124 Fn3-85 53 None 0.6468 None 0.884 N 0.361 0.144 0.228597637076 gnomAD-4.0.0 6.84961E-07 None None None None I None 2.99168E-05 0 None 0 0 None 0 0 0 0 0
T/A 27422 Fn3-87 54 rs760304866 0.0593 -0.486 None N 0.083 0.075 0.17258766438 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/A 27422 Fn3-87 54 rs760304866 0.0593 -0.486 None N 0.083 0.075 0.17258766438 gnomAD-4.0.0 1.75048E-05 None None None None N None 0 0 None 0 0 None 0 0 3.14426E-05 0 0
K/E 27521 Fn3-88 53 rs1060500417 0.8486 0.064 0.999 N 0.644 0.277 0.332133492242 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
K/E 27521 Fn3-88 53 rs1060500417 0.8486 0.064 0.999 N 0.644 0.277 0.332133492242 gnomAD-4.0.0 3.18249E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71677E-06 0 0
P/T 27622 Fn3-89 53 rs769189431 0.1813 -1.124 0.988 N 0.713 0.366 0.376393476264 gnomAD-2.1.1 1.43E-05 None None None None N None 1.24018E-04 2.83E-05 None 0 0 None 0 None 0 0 0
P/T 27622 Fn3-89 53 rs769189431 0.1813 -1.124 0.988 N 0.713 0.366 0.376393476264 gnomAD-3.1.2 6.58E-05 None None None None N None 2.41383E-04 0 0 0 0 None 0 0 0 0 0
P/T 27622 Fn3-89 53 rs769189431 0.1813 -1.124 0.988 N 0.713 0.366 0.376393476264 gnomAD-4.0.0 9.91618E-06 None None None None N None 1.86936E-04 3.33511E-05 None 0 0 None 0 0 0 0 0
G/E 28503 Fn3-95 54 rs1222429807 0.1191 -0.108 0.002 N 0.395 0.085 0.124217242631 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 9.98E-05 0 None 0 None 0 0 0
G/E 28503 Fn3-95 54 rs1222429807 0.1191 -0.108 0.002 N 0.395 0.085 0.124217242631 gnomAD-4.0.0 6.8432E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99467E-07 0 0
G/R 28503 Fn3-95 54 rs779691555 0.1439 -0.376 0.497 N 0.572 0.093 0.409533910539 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 4.66E-05 0 0
G/R 28503 Fn3-95 54 rs779691555 0.1439 -0.376 0.497 N 0.572 0.093 0.409533910539 gnomAD-4.0.0 1.59181E-06 None None None None N None 0 0 None 0 0 None 1.88658E-05 0 0 0 0
Q/R 28703 Fn3-97 53 rs1406320039 0.093 None 0.549 N 0.265 0.112 0.146414634003 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/R 28703 Fn3-97 53 rs1406320039 0.093 None 0.549 N 0.265 0.112 0.146414634003 gnomAD-4.0.0 6.57134E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47003E-05 0 0
N/H 28897 Fn3-98 53 rs1702786623 0.1028 None 0.896 N 0.373 0.176 0.186928172975 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/H 28897 Fn3-98 53 rs1702786623 0.1028 None 0.896 N 0.373 0.176 0.186928172975 gnomAD-4.0.0 6.57056E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46977E-05 0 0
N/K 28897 Fn3-98 53 rs756448014 0.2717 0.472 0.201 N 0.205 0.073 0.0806252709748 gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
N/K 28897 Fn3-98 53 rs756448014 0.2717 0.472 0.201 N 0.205 0.073 0.0806252709748 gnomAD-4.0.0 3.42125E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49763E-06 0 0
V/A 28994 Fn3-99 53 rs1215210190 0.0971 -0.864 None N 0.147 0.107 0.324161360171 gnomAD-2.1.1 7.15E-06 None None None None N None 4.13E-05 0 None 0 0 None 0 None 0 7.82E-06 0
V/A 28994 Fn3-99 53 rs1215210190 0.0971 -0.864 None N 0.147 0.107 0.324161360171 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/A 28994 Fn3-99 53 rs1215210190 0.0971 -0.864 None N 0.147 0.107 0.324161360171 gnomAD-4.0.0 8.67559E-06 None None None None N None 1.33451E-05 0 None 0 8.9214E-05 None 0 0 7.6282E-06 0 0
V/L 28994 Fn3-99 53 None 0.1186 None None N 0.127 0.071 0.149567049428 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
A/P 29190 Fn3-100 54 rs779302987 0.279 -0.341 0.497 N 0.501 0.184 0.202086224978 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
A/P 29190 Fn3-100 54 rs779302987 0.279 -0.341 0.497 N 0.501 0.184 0.202086224978 gnomAD-4.0.0 1.36833E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79886E-06 0 0
A/T 29190 Fn3-100 54 None 0.0775 None 0.001 N 0.329 0.024 0.0920862733494 gnomAD-4.0.0 1.36833E-06 None None None None N None 0 0 None 0 2.51915E-05 None 0 0 8.99431E-07 0 0
E/K 29586 Fn3-103 54 None 0.2383 None 0.999 N 0.559 0.339 0.336155897331 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/R 29685 Fn3-104 53 rs773157007 0.0847 -0.382 0.999 N 0.626 0.256 0.425970041486 gnomAD-2.1.1 1.61E-05 None None None None N None 0 1.15882E-04 None 0 0 None 0 None 0 0 0
K/R 29685 Fn3-104 53 rs773157007 0.0847 -0.382 0.999 N 0.626 0.256 0.425970041486 gnomAD-4.0.0 6.36452E-06 None None None None N None 0 9.14537E-05 None 0 0 None 0 0 0 0 0
T/I 29786 Fn3-105 53 rs753966916 0.1346 -0.033 0.001 N 0.095 0.288 None gnomAD-2.1.1 3.93E-05 None None None None N None 2.47954E-04 1.41427E-04 None 0 0 None 0 None 0 0 0
T/I 29786 Fn3-105 53 rs753966916 0.1346 -0.033 0.001 N 0.095 0.288 None gnomAD-3.1.2 8.55E-05 None None None None N None 3.13873E-04 0 0 0 0 None 0 0 0 0 0
T/I 29786 Fn3-105 53 rs753966916 0.1346 -0.033 0.001 N 0.095 0.288 None gnomAD-4.0.0 1.85911E-05 None None None None N None 2.93748E-04 1.00027E-04 None 0 0 None 0 0 0 0 3.20205E-05
T/S 29786 Fn3-105 53 None 0.0788 None 0.001 N 0.085 0.041 0.126345400529 gnomAD-4.0.0 2.05257E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69835E-06 0 0
H/Q 29985 Fn3-106 53 rs1327715051 0.1058 None 0.241 N 0.17 0.104 0.275215494804 gnomAD-3.1.2 1.31E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
H/Q 29985 Fn3-106 53 rs1327715051 0.1058 None 0.241 N 0.17 0.104 0.275215494804 gnomAD-4.0.0 1.3148E-05 None None None None I None 4.82812E-05 0 None 0 0 None 0 0 0 0 0
H/Y 29985 Fn3-106 53 rs557248616 0.1048 None 0.391 N 0.257 0.067 0.222439326576 gnomAD-4.0.0 1.20034E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
I/M 30082 Fn3-107 53 rs886038812 0.0933 -0.194 0.003 N 0.163 0.045 0.226586394389 gnomAD-2.1.1 3.18E-05 None None None None N None 1.14705E-04 0 None 0 0 None 0 None 0 0 0
I/M 30082 Fn3-107 53 rs886038812 0.0933 -0.194 0.003 N 0.163 0.045 0.226586394389 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
I/M 30082 Fn3-107 53 rs886038812 0.0933 -0.194 0.003 N 0.163 0.045 0.226586394389 gnomAD-4.0.0 3.09814E-06 None None None None N None 1.33415E-05 0 None 0 4.45792E-05 None 0 0 1.6951E-06 0 0
I/V 30082 Fn3-107 53 rs777636306 0.0711 -0.124 None N 0.111 0.052 0.259272394797 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
I/V 30082 Fn3-107 53 rs777636306 0.0711 -0.124 None N 0.111 0.052 0.259272394797 gnomAD-4.0.0 6.84162E-06 None None None None N None 0 2.23614E-05 None 0 0 None 0 1.7343E-04 5.39647E-06 1.15934E-05 1.6564E-05
S/L 30277 Fn3-108 54 rs1490223188 0.3771 -0.118 1.0 N 0.728 0.395 0.62434799699 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/L 30277 Fn3-108 54 rs1490223188 0.3771 -0.118 1.0 N 0.728 0.395 0.62434799699 gnomAD-4.0.0 1.59144E-06 None None None None I None 0 2.28655E-05 None 0 0 None 0 0 0 0 0
S/P 30277 Fn3-108 54 None 0.59 None 1.0 N 0.779 0.509 0.403040389579 gnomAD-4.0.0 1.59137E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85835E-06 0 0
T/I 30376 Fn3-109 53 rs1380978634 0.0806 0.227 None N 0.17 0.115 0.0482279557977 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
T/I 30376 Fn3-109 53 rs1380978634 0.0806 0.227 None N 0.17 0.115 0.0482279557977 gnomAD-4.0.0 6.36476E-06 None None None None N None 0 0 None 0 2.77285E-05 None 0 0 8.57432E-06 0 0
T/R 30376 Fn3-109 53 rs1380978634 0.1503 None 0.171 N 0.293 0.135 0.0666544352282 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/R 30376 Fn3-109 53 rs1380978634 0.1503 None 0.171 N 0.293 0.135 0.0666544352282 gnomAD-4.0.0 6.57246E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4702E-05 0 0
D/G 30672 Fn3-111 54 None 0.14 None 0.978 N 0.419 0.3 0.215109475489 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 30672 Fn3-111 54 rs1025405753 0.1098 None 0.978 N 0.428 0.244 0.235664433957 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 30672 Fn3-111 54 rs1025405753 0.1098 None 0.978 N 0.428 0.244 0.235664433957 gnomAD-4.0.0 3.84379E-06 None None None None N None 0 0 None 0 0 None 0 0 7.1794E-06 0 0
S/G 30771 Fn3-112 53 rs565582571 0.1027 -0.255 0.565 N 0.395 0.107 0.187945064343 gnomAD-2.1.1 6.37E-05 None None None None N None 2.2941E-04 0 None 0 0 None 0 None 0 0 0
S/G 30771 Fn3-112 53 rs565582571 0.1027 -0.255 0.565 N 0.395 0.107 0.187945064343 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
S/G 30771 Fn3-112 53 rs565582571 0.1027 -0.255 0.565 N 0.395 0.107 0.187945064343 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
S/G 30771 Fn3-112 53 rs565582571 0.1027 -0.255 0.565 N 0.395 0.107 0.187945064343 gnomAD-4.0.0 4.05911E-06 None None None None N None 6.97204E-05 0 None 0 0 None 0 0 0 0 0
S/R 30771 Fn3-112 53 None 0.8502 None 0.018 N 0.239 0.173 0.119812018005 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/T 30873 Fn3-113 53 None 0.0647 None None N 0.063 0.043 0.0482279557977 gnomAD-4.0.0 1.59107E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85786E-06 0 0
H/Q 31165 Fn3-115 53 rs752443804 0.0856 0.266 0.001 N 0.092 0.121 0.208816687407 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
H/Q 31165 Fn3-115 53 rs752443804 0.0856 0.266 0.001 N 0.092 0.121 0.208816687407 gnomAD-4.0.0 1.59107E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85798E-06 0 0
K/Q 31460 Fn3-117 53 None 0.1753 None 1.0 N 0.727 0.396 0.28798054836 gnomAD-4.0.0 1.36839E-06 None None None None I None 2.98829E-05 0 None 0 0 None 0 0 0 0 1.65667E-05
K/R 31460 Fn3-117 53 None 0.0799 None 0.999 N 0.603 0.33 0.379366414296 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 31961 Fn3-121 53 rs1696035879 0.0665 None 0.008 N 0.14 0.06 0.117506650769 gnomAD-4.0.0 1.59136E-06 None None None None I None 5.65611E-05 0 None 0 0 None 0 0 0 0 0
T/I 31961 Fn3-121 53 rs1336039632 0.1561 0.068 0.901 N 0.474 0.314 0.393927044628 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.65673E-04
T/S 32652 Fn3-126 53 None 0.2037 None 0.999 N 0.527 0.313 0.266385636622 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/M 33050 Fn3-129 53 rs780650379 0.3549 None 1.0 N 0.696 0.459 0.403609169532 gnomAD-4.0.0 4.7896E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29649E-06 0 0
K/N 33050 Fn3-129 53 None 0.4541 None 0.999 N 0.677 0.179 0.212008924253 gnomAD-4.0.0 3.60099E-06 None None None None N None 0 0 None 0 0 None 0 0 3.93753E-06 0 0
T/I 33444 Fn3-131 53 None 0.3227 None 0.999 N 0.808 0.413 0.385906861911 gnomAD-4.0.0 6.84354E-07 None None None None I None 0 2.23724E-05 None 0 0 None 0 0 0 0 0
T/K 33444 Fn3-131 53 None 0.2065 None 0.999 N 0.767 0.498 0.374076547971 gnomAD-4.0.0 2.05306E-06 None None None None I None 0 0 None 0 0 None 0 0 2.6987E-06 0 0
Q/E 33741 Fn3-132 53 None 0.2039 None 0.979 N 0.477 0.235 0.152612264143 gnomAD-4.0.0 6.84185E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99429E-07 0 0
Q/H 33741 Fn3-132 53 rs754625556 0.4621 -0.528 0.999 N 0.611 0.237 0.144782658237 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
Q/H 33741 Fn3-132 53 rs754625556 0.4621 -0.528 0.999 N 0.611 0.237 0.144782658237 gnomAD-4.0.0 1.5911E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.