Structural position:

  • Domain Type: Fn3
  • Aligned Position: 72
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand C'

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
R/C 15710 Fn3-1 54 rs370669650 0.2315 -0.077 0.022 N 0.318 0.215 None gnomAD-2.1.1 2.51E-05 None None None None I None 4.14E-05 2.83E-05 None 0 0 None 9.81E-05 None 0 1.57E-05 0
R/C 15710 Fn3-1 54 rs370669650 0.2315 -0.077 0.022 N 0.318 0.215 None gnomAD-3.1.2 1.98E-05 None None None None I None 4.84E-05 6.57E-05 0 0 0 None 0 0 0 0 0
R/C 15710 Fn3-1 54 rs370669650 0.2315 -0.077 0.022 N 0.318 0.215 None gnomAD-4.0.0 1.11634E-05 None None None None I None 2.67473E-05 3.34091E-05 None 0 0 None 0 0 6.78477E-06 4.3929E-05 3.20554E-05
R/G 15710 Fn3-1 54 None 0.216 None 0.221 N 0.355 0.214 0.346315397577 gnomAD-4.0.0 2.05387E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69968E-06 0 0
R/H 15710 Fn3-1 54 rs185689179 0.1002 -0.562 0.004 N 0.191 0.074 None gnomAD-2.1.1 4.3E-05 None None None None I None 4.14E-05 2.83E-05 None 0 3.61944E-04 None 6.54E-05 None 0 7.85E-06 0
R/H 15710 Fn3-1 54 rs185689179 0.1002 -0.562 0.004 N 0.191 0.074 None gnomAD-3.1.2 4.61E-05 None None None None I None 7.25E-05 0 0 0 5.84567E-04 None 0 0 1.47E-05 0 0
R/H 15710 Fn3-1 54 rs185689179 0.1002 -0.562 0.004 N 0.191 0.074 None gnomAD-4.0.0 2.54239E-05 None None None None I None 6.67289E-05 1.66923E-05 None 0 1.79003E-04 None 3.12412E-05 0 1.52657E-05 6.58848E-05 1.6022E-05
K/Q 15912 Fn3-3 54 None 0.1273 None 0.896 N 0.482 0.249 0.171388866994 gnomAD-4.0.0 6.99157E-07 None None None None I None 3.13381E-05 0 None 0 0 None 0 0 0 0 0
M/T 16503 Fn3-7 54 None 0.5436 None 0.425 N 0.317 0.267 0.662192778189 gnomAD-4.0.0 1.59411E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86431E-06 0 0
T/S 16804 Fn3-10 54 None 0.5055 None 0.999 N 0.517 0.297 0.28297238246 gnomAD-4.0.0 1.59361E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86198E-06 0 0
R/C 16905 Fn3-11 54 rs267599049 0.3671 -0.287 1.0 D 0.776 0.412 0.642361509819 gnomAD-2.1.1 5.66E-05 None None None None I None 6.47E-05 0 None 0 5.6E-05 None 2.61523E-04 None 0 3.59E-05 0
R/C 16905 Fn3-11 54 rs267599049 0.3671 -0.287 1.0 D 0.776 0.412 0.642361509819 gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
R/C 16905 Fn3-11 54 rs267599049 0.3671 -0.287 1.0 D 0.776 0.412 0.642361509819 gnomAD-4.0.0 1.86013E-05 None None None None I None 1.33697E-05 0 None 0 1.11792E-04 None 0 0 5.9358E-06 1.64719E-04 3.20441E-05
R/H 16905 Fn3-11 54 rs191539637 0.2049 -0.617 1.0 N 0.754 0.386 None gnomAD-2.1.1 4.70117E-04 None None None None I None 2.06902E-04 5.66E-05 None 2.42483E-03 3.09725E-04 None 3.27E-05 None 9.19559E-04 4.96885E-04 8.45309E-04
R/H 16905 Fn3-11 54 rs191539637 0.2049 -0.617 1.0 N 0.754 0.386 None gnomAD-3.1.2 5.26794E-04 None None None None I None 9.66E-05 6.56E-05 0 2.88184E-03 3.9032E-04 None 1.69907E-03 0 6.62681E-04 0 0
R/H 16905 Fn3-11 54 rs191539637 0.2049 -0.617 1.0 N 0.754 0.386 None 1000 genomes 3.99361E-04 None None None None I None 0 1.4E-03 None None 1E-03 0 None None None 0 None
R/H 16905 Fn3-11 54 rs191539637 0.2049 -0.617 1.0 N 0.754 0.386 None gnomAD-4.0.0 3.66426E-04 None None None None I None 1.20122E-04 6.672E-05 None 3.07578E-03 1.34192E-04 None 1.21913E-03 0 3.26476E-04 1.09818E-05 2.72296E-04
R/P 16905 Fn3-11 54 rs191539637 0.9343 -0.225 1.0 N 0.691 0.387 0.364730456448 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/P 16905 Fn3-11 54 rs191539637 0.9343 -0.225 1.0 N 0.691 0.387 0.364730456448 gnomAD-4.0.0 1.36902E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.15958E-05 1.65782E-05
R/S 16905 Fn3-11 54 rs267599049 0.7866 0.111 1.0 N 0.672 0.421 0.31501682445 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
H/Y 17200 Fn3-13 54 rs2055879782 0.0979 None None N 0.082 0.168 0.207176502487 gnomAD-3.1.2 6.59E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
H/Y 17200 Fn3-13 54 rs2055879782 0.0979 None None N 0.082 0.168 0.207176502487 gnomAD-4.0.0 2.03065E-06 None None None None I None 1.74941E-05 0 None 0 0 None 0 5.16529E-04 0 0 0
S/G 17522 Fn3-15 53 None 0.0769 None 0.012 N 0.196 0.065 0.0884992946249 gnomAD-4.0.0 6.84751E-07 None None None None I None 0 0 None 0 2.53537E-05 None 0 0 0 0 0
S/N 17522 Fn3-15 53 None 0.055 None None N 0.105 0.135 0.0297737177859 gnomAD-4.0.0 1.59432E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86261E-06 0 0
S/R 17522 Fn3-15 53 None 0.2807 None 0.055 N 0.415 0.066 0.149567049428 gnomAD-4.0.0 6.84751E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99886E-07 0 0
K/M 17622 Fn3-16 54 rs763564746 0.2975 0.229 0.999 N 0.421 0.389 0.355865052028 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
K/M 17622 Fn3-16 54 rs763564746 0.2975 0.229 0.999 N 0.421 0.389 0.355865052028 gnomAD-3.1.2 1.32E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
K/M 17622 Fn3-16 54 rs763564746 0.2975 0.229 0.999 N 0.421 0.389 0.355865052028 gnomAD-4.0.0 1.31624E-05 None None None None N None 2.41324E-05 0 None 0 0 None 0 0 1.47258E-05 0 0
K/N 17622 Fn3-16 54 None 0.3238 None 0.896 N 0.4 0.223 0.139678290688 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
K/R 17622 Fn3-16 54 rs763564746 0.0919 0.32 0.026 N 0.247 0.1 0.154104182512 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
K/R 17622 Fn3-16 54 rs763564746 0.0919 0.32 0.026 N 0.247 0.1 0.154104182512 gnomAD-4.0.0 1.84808E-05 None None None None N None 0 0 None 0 0 None 0 0 2.42936E-05 0 0
R/L 17915 Fn3-18 54 None 0.1261 None 0.251 N 0.461 0.181 0.282179105231 gnomAD-4.0.0 1.5942E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43488E-05 0
R/Q 17915 Fn3-18 54 rs758896047 0.0692 0.464 0.01 N 0.251 0.1 0.0884992946249 gnomAD-2.1.1 1.61E-05 None None None None N None 0 5.8E-05 None 0 0 None 6.54E-05 None 0 0 0
R/Q 17915 Fn3-18 54 rs758896047 0.0692 0.464 0.01 N 0.251 0.1 0.0884992946249 gnomAD-3.1.2 5.93E-05 None None None None N None 4.84E-05 3.9427E-04 0 0 0 None 0 0 0 2.07555E-04 0
R/Q 17915 Fn3-18 54 rs758896047 0.0692 0.464 0.01 N 0.251 0.1 0.0884992946249 gnomAD-4.0.0 2.56717E-05 None None None None N None 3.39236E-05 1.52729E-04 None 0 0 None 0 0 0 2.6842E-05 1.99476E-04
A/V 18219 Fn3-20 54 rs546735795 0.1979 0.025 0.704 N 0.33 0.297 0.435479573448 gnomAD-2.1.1 4.02E-06 None None None None I None 6.47E-05 0 None 0 0 None 0 None 0 0 0
A/V 18219 Fn3-20 54 rs546735795 0.1979 0.025 0.704 N 0.33 0.297 0.435479573448 gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
A/V 18219 Fn3-20 54 rs546735795 0.1979 0.025 0.704 N 0.33 0.297 0.435479573448 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
A/V 18219 Fn3-20 54 rs546735795 0.1979 0.025 0.704 N 0.33 0.297 0.435479573448 gnomAD-4.0.0 6.57825E-06 None None None None I None 2.40906E-05 0 None 0 0 None 0 0 0 0 0
P/A 18325 Fn3-21 54 rs374713945 0.0651 -1.755 0.051 N 0.241 0.116 None gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.9E-06 0
P/A 18325 Fn3-21 54 rs374713945 0.0651 -1.755 0.051 N 0.241 0.116 None gnomAD-4.0.0 1.3693E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99854E-07 1.1599E-05 0
P/R 18325 Fn3-21 54 rs879091548 0.1449 -0.757 0.876 N 0.443 0.237 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
P/R 18325 Fn3-21 54 rs879091548 0.1449 -0.757 0.876 N 0.443 0.237 None gnomAD-3.1.2 1.32E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 1.47E-05 0 0
P/R 18325 Fn3-21 54 rs879091548 0.1449 -0.757 0.876 N 0.443 0.237 None gnomAD-4.0.0 5.13256E-06 None None None None N None 1.6952E-05 0 None 0 0 None 0 0 7.18924E-06 0 0
P/S 18325 Fn3-21 54 None 0.1016 None 0.669 N 0.395 0.171 0.241078983079 gnomAD-4.0.0 2.05396E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69956E-06 0 0
P/T 18325 Fn3-21 54 None 0.0771 None 0.801 N 0.43 0.206 0.292787519742 gnomAD-4.0.0 4.79256E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39912E-06 0 1.65815E-05
R/C 18637 Fn3-23 59 rs374151130 0.4552 0.022 1.0 N 0.775 0.398 None gnomAD-2.1.1 4.03E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
R/C 18637 Fn3-23 59 rs374151130 0.4552 0.022 1.0 N 0.775 0.398 None gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
R/C 18637 Fn3-23 59 rs374151130 0.4552 0.022 1.0 N 0.775 0.398 None gnomAD-4.0.0 5.14614E-05 None None None None I None 1.33661E-05 0 None 0 0 None 0 0 6.86819E-05 0 1.60174E-05
R/H 18637 Fn3-23 59 rs758627195 0.2171 -0.615 1.0 N 0.779 0.386 None gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 9.81E-05 None 0 8.94E-06 0
R/H 18637 Fn3-23 59 rs758627195 0.2171 -0.615 1.0 N 0.779 0.386 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 4.1425E-04 0
R/H 18637 Fn3-23 59 rs758627195 0.2171 -0.615 1.0 N 0.779 0.386 None gnomAD-4.0.0 1.79789E-05 None None None None I None 0 0 None 0 0 None 0 0 2.54367E-06 2.74593E-04 1.60164E-05
R/L 18637 Fn3-23 59 rs758627195 0.5057 None 1.0 N 0.633 0.46 0.45553875121 gnomAD-4.0.0 6.84463E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99742E-07 0 0
R/S 18637 Fn3-23 59 rs374151130 0.7191 0.129 1.0 N 0.69 0.404 None gnomAD-2.1.1 3.23E-05 None None None None I None 0 0 None 0 0 None 0 None 0 7.15E-05 0
R/S 18637 Fn3-23 59 rs374151130 0.7191 0.129 1.0 N 0.69 0.404 None gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/S 18637 Fn3-23 59 rs374151130 0.7191 0.129 1.0 N 0.69 0.404 None gnomAD-4.0.0 1.48804E-05 None None None None I None 0 0 None 0 0 None 0 0 2.03502E-05 0 0
D/G 18937 Fn3-25 54 None 0.6067 None 0.996 N 0.626 0.495 0.233785782151 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/H 18937 Fn3-25 54 rs779010234 0.6654 0.134 1.0 N 0.663 0.413 0.29385284311 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 5.61E-05 None 0 None 0 0 0
D/H 18937 Fn3-25 54 rs779010234 0.6654 0.134 1.0 N 0.663 0.413 0.29385284311 gnomAD-4.0.0 1.59249E-06 None None None None I None 0 0 None 0 2.7818E-05 None 0 0 0 0 0
K/Q 19041 Fn3-26 54 rs1334101213 0.1515 0.212 0.988 N 0.376 0.218 0.244539031024 gnomAD-2.1.1 7.17E-06 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 0 0
K/Q 19041 Fn3-26 54 rs1334101213 0.1515 0.212 0.988 N 0.376 0.218 0.244539031024 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
K/Q 19041 Fn3-26 54 rs1334101213 0.1515 0.212 0.988 N 0.376 0.218 0.244539031024 gnomAD-4.0.0 4.96182E-06 None None None None N None 1.0686E-04 0 None 0 0 None 0 0 0 0 0
D/E 19337 Fn3-28 54 None 0.1148 None 0.005 N 0.124 0.071 0.136095386433 gnomAD-4.0.0 3.1844E-06 None None None None N None 0 0 None 4.76872E-05 0 None 0 0 0 1.43349E-05 0
D/N 19337 Fn3-28 54 rs1239348052 0.1004 0.348 0.801 N 0.471 0.27 0.218112801441 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
D/N 19337 Fn3-28 54 rs1239348052 0.1004 0.348 0.801 N 0.471 0.27 0.218112801441 gnomAD-4.0.0 1.59223E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86007E-06 0 0
T/I 19733 Fn3-31 54 rs749461231 0.2359 0.008 0.982 N 0.456 0.346 0.36076525451 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
T/I 19733 Fn3-31 54 rs749461231 0.2359 0.008 0.982 N 0.456 0.346 0.36076525451 gnomAD-4.0.0 1.59166E-06 None None None None N None 5.65931E-05 0 None 0 0 None 0 0 0 0 0
T/S 19733 Fn3-31 54 rs749461231 0.0998 -0.697 0.885 N 0.45 0.114 0.130388298395 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/S 19733 Fn3-31 54 rs749461231 0.0998 -0.697 0.885 N 0.45 0.114 0.130388298395 gnomAD-4.0.0 1.59166E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
T/I 20029 Fn3-33 53 None 0.1485 None 0.884 N 0.343 0.354 0.316198179892 gnomAD-4.0.0 6.84351E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99604E-07 0 0
T/N 20029 Fn3-33 53 rs2050252504 0.1345 None 1.0 N 0.67 0.35 0.319686207203 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
T/N 20029 Fn3-33 53 rs2050252504 0.1345 None 1.0 N 0.67 0.35 0.319686207203 gnomAD-4.0.0 2.47957E-06 None None None None N None 2.67251E-05 0 None 0 0 None 0 0 1.69556E-06 0 0
G/A 20721 Fn3-38 54 rs1656930545 0.242 None 0.992 N 0.487 0.318 0.293502639404 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.42E-05 0 0 0 0
G/A 20721 Fn3-38 54 rs1656930545 0.242 None 0.992 N 0.487 0.318 0.293502639404 gnomAD-4.0.0 6.58051E-06 None None None None N None 0 0 None 0 0 None 9.41974E-05 0 0 0 0
S/N 21016 Fn3-40 54 None 0.091 None 0.722 N 0.378 0.153 0.226586394389 gnomAD-4.0.0 6.84504E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99747E-07 0 0
S/T 21016 Fn3-40 54 rs1169239147 0.0543 None 0.034 N 0.19 0.089 0.177238962908 gnomAD-4.0.0 2.73802E-06 None None None None I None 0 8.95015E-05 None 0 0 None 0 0 0 0 0
A/T 21122 Fn3-41 59 rs377528392 0.1054 -0.183 0.852 N 0.289 0.225 None gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
A/T 21122 Fn3-41 59 rs377528392 0.1054 -0.183 0.852 N 0.289 0.225 None gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 21122 Fn3-41 59 rs377528392 0.1054 -0.183 0.852 N 0.289 0.225 None gnomAD-4.0.0 2.56477E-06 None None None None I None 0 0 None 0 0 None 0 0 4.79072E-06 0 0
T/A 21712 Fn3-45 54 rs1278321308 0.0839 0.014 None N 0.077 0.06 0.0716867268079 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.66003E-04
T/A 21712 Fn3-45 54 rs1278321308 0.0839 0.014 None N 0.077 0.06 0.0716867268079 gnomAD-4.0.0 1.59226E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43328E-05 0
T/N 21712 Fn3-45 54 rs767459998 0.1277 0.185 0.062 N 0.214 0.197 0.204665344411 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
T/N 21712 Fn3-45 54 rs767459998 0.1277 0.185 0.062 N 0.214 0.197 0.204665344411 gnomAD-4.0.0 1.59227E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86008E-06 0 0
A/P 21810 Fn3-46 54 None 0.283 None 0.055 N 0.444 0.118 0.0846915920261 gnomAD-4.0.0 6.85079E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00114E-07 0 0
A/T 21810 Fn3-46 54 rs752825084 0.062 -1.077 None N 0.089 0.096 0.0482279557977 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.99E-06 0
A/T 21810 Fn3-46 54 rs752825084 0.062 -1.077 None N 0.089 0.096 0.0482279557977 gnomAD-4.0.0 6.85079E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00114E-07 0 0
A/V 21810 Fn3-46 54 rs2048304433 0.0867 None None N 0.129 0.049 0.40722173914 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/V 21810 Fn3-46 54 rs2048304433 0.0867 None None N 0.129 0.049 0.40722173914 gnomAD-4.0.0 1.24088E-06 None None None None N None 1.33561E-05 0 None 0 0 None 0 0 0 0 1.6039E-05
P/L 22209 Fn3-49 54 rs779009635 0.5318 -0.138 0.976 N 0.645 0.436 0.711619551443 gnomAD-2.1.1 8.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
P/L 22209 Fn3-49 54 rs779009635 0.5318 -0.138 0.976 N 0.645 0.436 0.711619551443 gnomAD-4.0.0 2.05388E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69949E-06 0 0
P/T 22209 Fn3-49 54 None 0.5011 None 0.988 N 0.565 0.354 0.500868654924 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/F 22503 Fn3-51 53 None 0.3095 None 0.773 N 0.561 0.311 0.672880393974 gnomAD-4.0.0 6.84396E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65739E-05
S/P 22503 Fn3-51 53 None 0.6318 None 0.773 N 0.506 0.202 0.296679040009 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/Y 22503 Fn3-51 53 None 0.2535 None 0.912 D 0.535 0.328 0.682517699708 gnomAD-4.0.0 2.73758E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59868E-06 0 0
T/I 22796 Fn3-53 54 rs756135570 0.1349 0.23 0.032 N 0.201 0.158 0.254244900254 gnomAD-2.1.1 8.06E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 8.91E-06 0
T/I 22796 Fn3-53 54 rs756135570 0.1349 0.23 0.032 N 0.201 0.158 0.254244900254 gnomAD-4.0.0 3.18521E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86076E-06 1.43332E-05 0
V/D 22894 Fn3-54 54 rs2046759146 0.4454 None 0.949 N 0.623 0.358 0.545130385147 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/D 22894 Fn3-54 54 rs2046759146 0.4454 None 0.949 N 0.623 0.358 0.545130385147 gnomAD-4.0.0 6.57471E-06 None None None None I None 2.41371E-05 0 None 0 0 None 0 0 0 0 0
T/A 23192 Fn3-56 54 rs1343160471 0.0711 0.047 None N 0.053 0.11 0.158396225186 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/A 23192 Fn3-56 54 rs1343160471 0.0711 0.047 None N 0.053 0.11 0.158396225186 gnomAD-4.0.0 1.59164E-06 None None None None I None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
T/I 23192 Fn3-56 54 rs1319888327 0.1228 0.28 0.007 N 0.286 0.06 0.193865811164 gnomAD-2.1.1 8.04E-06 None None None None I None 1.29232E-04 0 None 0 0 None 0 None 0 0 0
T/I 23192 Fn3-56 54 rs1319888327 0.1228 0.28 0.007 N 0.286 0.06 0.193865811164 gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
T/I 23192 Fn3-56 54 rs1319888327 0.1228 0.28 0.007 N 0.286 0.06 0.193865811164 gnomAD-4.0.0 7.68923E-06 None None None None I None 8.46224E-05 0 None 0 0 None 0 0 0 0 2.84527E-05
T/S 23192 Fn3-56 54 rs1343160471 0.0962 None 0.003 N 0.135 0.065 0.117506650769 gnomAD-4.0.0 3.18327E-06 None None None None I None 0 0 None 0 5.54539E-05 None 0 0 0 0 0
T/I 23294 Fn3-57 55 None 0.2023 None 0.007 N 0.233 0.251 0.301789629655 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 6.17284E-04 0 0 0
A/P 23879 Fn3-61 54 rs778238304 0.3963 0.101 0.966 N 0.321 0.27 0.379020345274 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.65782E-04
A/P 23879 Fn3-61 54 rs778238304 0.3963 0.101 0.966 N 0.321 0.27 0.379020345274 gnomAD-4.0.0 2.05279E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79913E-06 0 1.65678E-05
A/T 23879 Fn3-61 54 rs778238304 0.0622 -0.225 0.051 N 0.161 0.152 0.208816687407 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
A/T 23879 Fn3-61 54 rs778238304 0.0622 -0.225 0.051 N 0.161 0.152 0.208816687407 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 23879 Fn3-61 54 rs778238304 0.0622 -0.225 0.051 N 0.161 0.152 0.208816687407 gnomAD-4.0.0 3.16072E-05 None None None None I None 0 0 None 0 0 None 0 0 3.81467E-05 0 9.60799E-05
A/V 23879 Fn3-61 54 rs566803857 0.0774 None 0.669 N 0.225 0.171 0.284150004643 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/G 23977 Fn3-62 54 None 0.1126 None 0.472 N 0.224 0.243 0.215869574891 gnomAD-4.0.0 9.60257E-06 None None None None I None 0 0 None 0 0 None 0 0 1.05E-05 0 0
S/N 23977 Fn3-62 54 rs750632838 0.2663 0.1 0.012 N 0.116 0.066 0.162503812791 gnomAD-2.1.1 8.07E-06 None None None None I None 0 0 None 0 1.12133E-04 None 0 None 0 0 0
S/N 23977 Fn3-62 54 rs750632838 0.2663 0.1 0.012 N 0.116 0.066 0.162503812791 gnomAD-4.0.0 7.96026E-06 None None None None I None 0 0 None 0 1.11216E-04 None 0 0 2.85963E-06 0 0
K/I 24275 Fn3-64 54 rs199860952 0.5328 0.616 0.317 N 0.334 0.135 None gnomAD-2.1.1 4.57E-05 None None None None I None 0 0 None 0 0 None 0 None 1.00644E-04 7.83E-05 0
K/I 24275 Fn3-64 54 rs199860952 0.5328 0.616 0.317 N 0.334 0.135 None gnomAD-3.1.2 6.57E-05 None None None None I None 0 0 0 0 0 None 9.42E-05 0 1.32376E-04 0 0
K/I 24275 Fn3-64 54 rs199860952 0.5328 0.616 0.317 N 0.334 0.135 None gnomAD-4.0.0 1.2624E-04 None None None None I None 0 0 None 0 0 None 6.35789E-05 0 1.64446E-04 0 6.58393E-05
T/I 24961 Fn3-69 54 None 0.0924 None 0.966 N 0.308 0.233 0.370424759081 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 25059 Fn3-70 54 None 0.6536 None 0.032 N 0.215 0.324 0.317084106153 gnomAD-4.0.0 2.73721E-06 None None None None I None 5.98015E-05 0 None 0 0 None 0 0 1.79918E-06 0 0
T/K 25059 Fn3-70 54 rs1374355756 0.6869 0.067 0.942 N 0.337 0.412 0.433823933641 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
T/K 25059 Fn3-70 54 rs1374355756 0.6869 0.067 0.942 N 0.337 0.412 0.433823933641 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
T/K 25059 Fn3-70 54 rs1374355756 0.6869 0.067 0.942 N 0.337 0.412 0.433823933641 gnomAD-4.0.0 5.57834E-06 None None None None I None 0 0 None 0 0 None 0 0 7.62964E-06 0 0
R/C 25357 Fn3-72 54 rs145437410 0.2979 0.003 0.984 N 0.421 0.318 None gnomAD-2.1.1 3.22E-05 None None None None I None 0 0 None 0 3.91586E-04 None 0 None 4.65E-05 0 0
R/C 25357 Fn3-72 54 rs145437410 0.2979 0.003 0.984 N 0.421 0.318 None gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.93648E-04 None 0 0 0 0 0
R/C 25357 Fn3-72 54 rs145437410 0.2979 0.003 0.984 N 0.421 0.318 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
R/C 25357 Fn3-72 54 rs145437410 0.2979 0.003 0.984 N 0.421 0.318 None gnomAD-4.0.0 2.54132E-05 None None None None I None 0 0 None 0 7.59335E-04 None 3.12823E-05 0 3.39108E-06 0 1.60092E-05
R/H 25357 Fn3-72 54 rs397517703 0.1428 -0.619 0.005 N 0.273 0.071 None gnomAD-2.1.1 3.22E-05 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 6.24E-05 0
R/H 25357 Fn3-72 54 rs397517703 0.1428 -0.619 0.005 N 0.273 0.071 None gnomAD-3.1.2 1.97E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
R/H 25357 Fn3-72 54 rs397517703 0.1428 -0.619 0.005 N 0.273 0.071 None gnomAD-4.0.0 1.79761E-05 None None None None I None 1.33579E-05 3.336E-05 None 0 0 None 0 0 2.03463E-05 2.19592E-05 0
R/P 25357 Fn3-72 54 None 0.7839 None 0.705 N 0.47 0.22 0.357929162469 gnomAD-4.0.0 6.84363E-07 None None None None I None 0 2.23674E-05 None 0 0 None 0 0 0 0 0
T/I 25459 Fn3-73 55 None 0.1459 None 0.983 N 0.557 0.229 0.355865052028 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/C 26439 Fn3-80 54 rs372968732 0.3357 -0.342 1.0 N 0.584 0.376 None gnomAD-2.1.1 2.82E-05 None None None None I None 6.47E-05 8.71E-05 None 0 0 None 0 None 0 2.67E-05 0
R/C 26439 Fn3-80 54 rs372968732 0.3357 -0.342 1.0 N 0.584 0.376 None gnomAD-3.1.2 2.63E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 26439 Fn3-80 54 rs372968732 0.3357 -0.342 1.0 N 0.584 0.376 None gnomAD-4.0.0 2.9755E-05 None None None None I None 9.34879E-05 5.0045E-05 None 0 0 None 0 0 3.13652E-05 0 1.60159E-05
R/H 26439 Fn3-80 54 rs187941835 0.1723 -0.558 0.159 N 0.273 0.111 None gnomAD-2.1.1 1.61E-05 None None None None I None 0 2.9E-05 None 0 1.11919E-04 None 3.27E-05 None 0 0 0
R/H 26439 Fn3-80 54 rs187941835 0.1723 -0.558 0.159 N 0.273 0.111 None gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/H 26439 Fn3-80 54 rs187941835 0.1723 -0.558 0.159 N 0.273 0.111 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
R/H 26439 Fn3-80 54 rs187941835 0.1723 -0.558 0.159 N 0.273 0.111 None gnomAD-4.0.0 3.40917E-05 None None None None I None 0 5.00334E-05 None 0 4.46608E-05 None 3.13519E-05 0 3.98422E-05 1.09806E-05 0
T/A 27125 Fn3-85 54 rs1362825687 0.0803 0.027 None N 0.09 0.075 0.1749357433 gnomAD-2.1.1 4.08E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.04E-06 0
T/A 27125 Fn3-85 54 rs1362825687 0.0803 0.027 None N 0.09 0.075 0.1749357433 gnomAD-4.0.0 6.84869E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.6587E-05
T/I 27125 Fn3-85 54 rs1407261959 0.0932 None None N 0.167 0.074 0.136095386433 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 27125 Fn3-85 54 rs1407261959 0.0932 None None N 0.167 0.074 0.136095386433 gnomAD-4.0.0 6.57523E-06 None None None None I None 2.41453E-05 0 None 0 0 None 0 0 0 0 0
T/P 27125 Fn3-85 54 rs1362825687 0.3388 None 0.484 N 0.358 0.156 0.263140351381 gnomAD-4.0.0 2.73947E-06 None None None None I None 0 0 None 0 0 None 0 0 2.70002E-06 0 1.6587E-05
T/I 27223 Fn3-86 54 rs755648922 0.6413 -0.168 1.0 N 0.631 0.419 0.443999229985 gnomAD-2.1.1 4.1E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.13E-06 0
T/I 27223 Fn3-86 54 rs755648922 0.6413 -0.168 1.0 N 0.631 0.419 0.443999229985 gnomAD-4.0.0 6.16495E-06 None None None None I None 0 0 None 0 0 None 0 0 6.30097E-06 0 3.31719E-05
K/N 27522 Fn3-88 54 None 0.5404 None 0.967 N 0.582 0.237 0.178374595973 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
I/N 28207 Fn3-93 54 None 0.0846 None 0.017 N 0.371 0.07 0.264547087235 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
T/I 28305 Fn3-94 54 None 0.4061 None 0.999 N 0.612 0.445 0.544082543865 gnomAD-4.0.0 2.73733E-06 None None None None I None 0 0 None 0 0 None 0 0 0 4.63736E-05 0
T/S 28305 Fn3-94 54 None 0.1269 None 0.992 N 0.392 0.255 0.244539031024 gnomAD-4.0.0 6.84332E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
K/I 28603 Fn3-96 54 None 0.4666 None 0.967 N 0.645 0.345 0.543209242439 gnomAD-4.0.0 1.59124E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02425E-05
K/N 28603 Fn3-96 54 rs778444893 0.5229 None 0.967 N 0.581 0.232 0.12205267543 gnomAD-4.0.0 6.84212E-07 None None None None I None 0 0 None 0 0 None 0 1.7343E-04 0 0 0
S/G 28704 Fn3-97 54 None 0.0686 None None N 0.103 0.067 0.158396225186 gnomAD-4.0.0 4.80131E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25003E-06 0 0
L/P 29290 Fn3-101 54 None 0.4603 None 0.106 N 0.519 0.133 0.647776319867 gnomAD-4.0.0 6.00161E-06 None None None None I None 0 0 None 0 0 None 0 0 6.56251E-06 0 0
T/I 29388 Fn3-102 54 rs775200192 0.4265 -0.1 0.978 N 0.673 0.393 0.468504517574 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
T/I 29388 Fn3-102 54 rs775200192 0.4265 -0.1 0.978 N 0.673 0.393 0.468504517574 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
T/I 29388 Fn3-102 54 rs775200192 0.4265 -0.1 0.978 N 0.673 0.393 0.468504517574 gnomAD-4.0.0 3.84337E-06 None None None None N None 5.07408E-05 0 None 0 0 None 0 0 0 0 0
T/N 29388 Fn3-102 54 rs775200192 0.2544 -0.397 0.989 N 0.689 0.387 0.465294738428 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 8.88E-06 0
T/N 29388 Fn3-102 54 rs775200192 0.2544 -0.397 0.989 N 0.689 0.387 0.465294738428 gnomAD-4.0.0 3.18261E-06 None None None None N None 0 0 None 0 2.7787E-05 None 0 0 2.85801E-06 0 0
E/D 29686 Fn3-104 54 rs1164496806 0.0758 -0.22 0.035 N 0.141 0.071 0.202086224978 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
E/K 29686 Fn3-104 54 None 0.3741 None 0.92 N 0.435 0.256 0.271763555656 gnomAD-4.0.0 6.84199E-07 None None None None I None 0 0 None 0 2.51915E-05 None 0 0 0 0 0
E/Q 29686 Fn3-104 54 None 0.2769 None 0.959 N 0.435 0.243 0.267755039894 gnomAD-4.0.0 6.84199E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99444E-07 0 0
K/E 29787 Fn3-105 54 rs1217080477 0.1377 0.071 0.027 N 0.283 0.107 0.186928172975 gnomAD-2.1.1 1.21E-05 None None None None I None 0 8.69E-05 None 0 0 None 0 None 0 0 0
K/E 29787 Fn3-105 54 rs1217080477 0.1377 0.071 0.027 N 0.283 0.107 0.186928172975 gnomAD-4.0.0 4.77345E-06 None None None None I None 0 6.85871E-05 None 0 0 None 0 0 0 0 0
K/N 29787 Fn3-105 54 None 0.2715 None 0.001 N 0.106 0.095 0.0297737177859 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
S/L 30377 Fn3-109 54 None 0.0647 None 0.193 N 0.249 0.215 0.448597761117 gnomAD-4.0.0 6.84194E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99455E-07 0 0
T/I 30474 Fn3-110 53 rs1161044987 0.2615 0.098 0.001 N 0.211 0.089 0.215109475489 gnomAD-2.1.1 4.03E-06 None None None None I None 6.47E-05 0 None 0 0 None 0 None 0 0 0
T/I 30474 Fn3-110 53 rs1161044987 0.2615 0.098 0.001 N 0.211 0.089 0.215109475489 gnomAD-4.0.0 1.59203E-06 None None None None I None 5.65931E-05 0 None 0 0 None 0 0 0 0 0
R/Q 30773 Fn3-112 55 rs776649477 0.1128 0.12 0.981 N 0.501 0.186 0.199424873507 gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 1.11309E-04 None 0 None 0 0 0
R/Q 30773 Fn3-112 55 rs776649477 0.1128 0.12 0.981 N 0.501 0.186 0.199424873507 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/Q 30773 Fn3-112 55 rs776649477 0.1128 0.12 0.981 N 0.501 0.186 0.199424873507 gnomAD-4.0.0 6.19659E-06 None None None None N None 0 0 None 0 2.22777E-05 None 0 0 6.78056E-06 0 1.60092E-05
E/K 30874 Fn3-113 54 None 0.1402 None 0.565 N 0.429 0.249 0.208816687407 gnomAD-4.0.0 1.59108E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02371E-05
V/L 31461 Fn3-117 54 rs1206905148 0.1116 None 0.001 N 0.093 0.098 0.213573922156 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/L 31461 Fn3-117 54 rs1206905148 0.1116 None 0.001 N 0.093 0.098 0.213573922156 gnomAD-4.0.0 6.57307E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47037E-05 0 0
T/A 31562 Fn3-118 57 None 0.2387 None 0.981 N 0.609 0.357 0.317958651998 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
T/N 31562 Fn3-118 57 rs1697337398 0.4138 None 0.999 N 0.65 0.384 0.551798466036 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/N 31562 Fn3-118 57 rs1697337398 0.4138 None 0.999 N 0.65 0.384 0.551798466036 gnomAD-4.0.0 6.57592E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47063E-05 0 0
D/E 31860 Fn3-120 54 None 0.1256 None 0.134 N 0.167 0.065 0.17948927462 gnomAD-4.0.0 6.84255E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99551E-07 0 0
N/D 31962 Fn3-121 54 rs369087584 0.1126 0.363 0.014 N 0.239 0.148 None gnomAD-2.1.1 4.28E-05 None None None None I None 4.54621E-04 2.83E-05 None 0 0 None 0 None 0 0 0
N/D 31962 Fn3-121 54 rs369087584 0.1126 0.363 0.014 N 0.239 0.148 None gnomAD-3.1.2 1.90549E-04 None None None None I None 6.7548E-04 0 0 0 0 None 0 0 0 0 4.77555E-04
N/D 31962 Fn3-121 54 rs369087584 0.1126 0.363 0.014 N 0.239 0.148 None gnomAD-4.0.0 3.65621E-05 None None None None I None 7.47484E-04 1.66711E-05 None 0 0 None 0 0 0 0 3.20215E-05
N/I 31962 Fn3-121 54 rs535943753 0.1772 0.165 0.033 N 0.461 0.103 0.426787303895 gnomAD-2.1.1 3.21E-05 None None None None I None 3.71901E-04 0 None 0 0 None 0 None 0 0 0
N/I 31962 Fn3-121 54 rs535943753 0.1772 0.165 0.033 N 0.461 0.103 0.426787303895 gnomAD-3.1.2 7.88E-05 None None None None I None 2.89464E-04 0 0 0 0 None 0 0 0 0 0
N/I 31962 Fn3-121 54 rs535943753 0.1772 0.165 0.033 N 0.461 0.103 0.426787303895 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
N/I 31962 Fn3-121 54 rs535943753 0.1772 0.165 0.033 N 0.461 0.103 0.426787303895 gnomAD-4.0.0 1.67307E-05 None None None None I None 3.46463E-04 0 None 0 0 None 0 0 0 0 1.60051E-05
V/A 32552 Fn3-125 54 None 0.1781 None 0.625 N 0.229 0.221 0.513394077459 gnomAD-4.0.0 1.59237E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86012E-06 0 0
V/I 32552 Fn3-125 54 rs1694451017 0.0796 None 0.012 N 0.187 0.057 0.419713421852 gnomAD-4.0.0 1.59232E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86004E-06 0 0
T/I 32950 Fn3-128 55 None 0.3463 None 1.0 N 0.659 0.434 0.451786746415 gnomAD-4.0.0 1.59131E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
E/K 33051 Fn3-129 54 rs144319649 0.2754 0.488 0.334 N 0.557 0.178 None gnomAD-2.1.1 2.81E-05 None None None None N None 0 0 None 0 3.89451E-04 None 0 None 0 0 0
E/K 33051 Fn3-129 54 rs144319649 0.2754 0.488 0.334 N 0.557 0.178 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 3.85208E-04 None 0 0 1.47E-05 0 0
E/K 33051 Fn3-129 54 rs144319649 0.2754 0.488 0.334 N 0.557 0.178 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
E/K 33051 Fn3-129 54 rs144319649 0.2754 0.488 0.334 N 0.557 0.178 None gnomAD-4.0.0 1.54916E-05 None None None None N None 0 0 None 0 4.67977E-04 None 0 0 2.54293E-06 0 1.60067E-05
E/K 33445 Fn3-131 54 rs774013465 0.1795 -0.712 0.001 N 0.171 0.146 0.216624796971 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/K 33445 Fn3-131 54 rs774013465 0.1795 -0.712 0.001 N 0.171 0.146 0.216624796971 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 0 6.20347E-04 0
E/K 33445 Fn3-131 54 rs774013465 0.1795 -0.712 0.001 N 0.171 0.146 0.216624796971 gnomAD-4.0.0 8.05659E-06 None None None None N None 1.33337E-05 0 None 0 0 None 0 0 0 1.31764E-04 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.