Structural position:

  • Domain Type: Fn3
  • Aligned Position: 92
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand E

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
T/A 15717 Fn3-1 61 rs1249764555 0.1219 -0.825 0.999 D 0.563 0.414 0.500805711387 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
T/A 15717 Fn3-1 61 rs1249764555 0.1219 -0.825 0.999 D 0.563 0.414 0.500805711387 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.57E-05 0 0 0 None 0 0 0 0 0
T/A 15717 Fn3-1 61 rs1249764555 0.1219 -0.825 0.999 D 0.563 0.414 0.500805711387 gnomAD-4.0.0 2.56572E-06 None None None None N None 0 3.39536E-05 None 0 0 None 0 0 0 0 0
T/I 15717 Fn3-1 61 rs1202910952 0.2226 None 1.0 D 0.855 0.497 0.624893835469 gnomAD-4.0.0 3.42301E-06 None None None None N None 0 0 None 0 0 None 1.87287E-05 0 3.59946E-06 0 0
T/P 15717 Fn3-1 61 None 0.3057 None 1.0 D 0.858 0.51 0.596957824077 gnomAD-4.0.0 1.59334E-06 None None None None N None 0 0 None 0 0 None 0 2.41896E-04 0 0 0
T/A 15819 Fn3-2 62 None 0.0843 None 0.454 D 0.379 0.179 0.212008924253 gnomAD-4.0.0 1.36922E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79985E-06 0 0
T/I 15819 Fn3-2 62 rs2057647583 0.1167 None 0.022 N 0.24 0.179 0.343101102393 gnomAD-4.0.0 3.18695E-06 None None None None N None 5.67859E-05 0 None 0 0 None 0 0 2.86297E-06 0 0
K/Q 15920 Fn3-3 62 rs775513269 0.1516 -0.475 0.998 N 0.631 0.293 0.18995819373 gnomAD-2.1.1 4.46E-05 None None None None N None 0 3.57455E-04 None 0 0 None 0 None 0 0 0
K/Q 15920 Fn3-3 62 rs775513269 0.1516 -0.475 0.998 N 0.631 0.293 0.18995819373 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
K/Q 15920 Fn3-3 62 rs775513269 0.1516 -0.475 0.998 N 0.631 0.293 0.18995819373 gnomAD-4.0.0 1.89511E-05 None None None None N None 0 2.63126E-04 None 0 0 None 0 0 2.49368E-06 0 0
K/R 15920 Fn3-3 62 rs1223537376 0.084 None 0.467 N 0.335 0.122 0.193865811164 gnomAD-4.0.0 1.70641E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.62343E-05 0
T/I 16115 Fn3-4 61 rs1361995359 0.1201 0.22 0.997 D 0.795 0.45 0.591466401951 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
T/I 16115 Fn3-4 61 rs1361995359 0.1201 0.22 0.997 D 0.795 0.45 0.591466401951 gnomAD-4.0.0 4.10984E-06 None None None None N None 0 0 None 0 0 None 0 0 5.40149E-06 0 0
T/R 16115 Fn3-4 61 None 0.1611 None 0.993 N 0.796 0.421 0.717697456393 gnomAD-4.0.0 6.84974E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00249E-07 0 0
E/K 16215 Fn3-5 61 None 0.1821 None 0.103 N 0.261 0.222 0.156986980423 gnomAD-4.0.0 6.91755E-07 None None None None N None 0 0 None 0 0 None 0 0 9.06434E-07 0 0
E/Q 16215 Fn3-5 61 rs1193666714 0.1345 None 0.103 N 0.389 0.115 0.117506650769 gnomAD-4.0.0 6.91755E-07 None None None None N None 0 0 None 0 0 None 0 0 9.06434E-07 0 0
K/R 16411 Fn3-6 61 None 0.0823 None 0.003 N 0.203 0.068 0.269558022972 gnomAD-4.0.0 1.59395E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86197E-06 0 0
R/K 16511 Fn3-7 62 rs1372771873 0.2759 0.154 0.003 N 0.288 0.078 0.275215494804 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
R/K 16511 Fn3-7 62 rs1372771873 0.2759 0.154 0.003 N 0.288 0.078 0.275215494804 gnomAD-4.0.0 1.59581E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43653E-05 0
L/F 16611 Fn3-8 61 rs758670411 0.0957 -0.954 None N 0.168 0.055 0.220303561663 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 1.13122E-04 None 0 None 0 0 0
L/F 16611 Fn3-8 61 rs758670411 0.0957 -0.954 None N 0.168 0.055 0.220303561663 gnomAD-4.0.0 1.59379E-06 None None None None N None 0 0 None 0 2.79298E-05 None 0 0 0 0 0
T/R 16711 Fn3-9 61 None 0.4856 None 0.993 N 0.797 0.443 0.594705806306 gnomAD-4.0.0 1.59393E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8622E-06 0 0
K/N 16913 Fn3-11 62 rs559219228 0.5592 -0.926 0.98 N 0.506 0.221 0.221734844693 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/N 16913 Fn3-11 62 rs559219228 0.5592 -0.926 0.98 N 0.506 0.221 0.221734844693 gnomAD-4.0.0 1.59292E-06 None None None None N None 0 2.28833E-05 None 0 0 None 0 0 0 0 0
K/Q 16913 Fn3-11 62 None 0.1744 None 0.489 N 0.404 0.156 0.246215685461 gnomAD-4.0.0 1.59296E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86144E-06 0 0
T/P 17107 Fn3-12 61 None 0.1361 None 0.001 N 0.247 0.327 0.270889551736 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/S 17107 Fn3-12 61 None 0.1086 None 0.007 N 0.169 0.114 0.224531998449 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 17208 Fn3-13 62 None 0.1845 None 0.997 N 0.745 0.475 0.486920840936 gnomAD-4.0.0 2.73798E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59932E-06 0 0
T/R 17208 Fn3-13 62 None 0.2045 None 0.997 D 0.747 0.371 0.538097488659 gnomAD-4.0.0 6.84495E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99829E-07 0 0
N/K 17530 Fn3-15 61 rs777245474 0.0803 0.098 None N 0.218 0.082 0.0297737177859 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
N/K 17530 Fn3-15 61 rs777245474 0.0803 0.098 None N 0.218 0.082 0.0297737177859 gnomAD-4.0.0 6.84862E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99944E-07 0 0
N/S 17530 Fn3-15 61 rs762214300 0.0701 -0.373 0.027 N 0.485 0.096 0.167679373172 gnomAD-2.1.1 7.91E-05 None None None None N None 0 5.69E-05 None 0 0 None 0 None 1.60552E-04 1.25861E-04 0
N/S 17530 Fn3-15 61 rs762214300 0.0701 -0.373 0.027 N 0.485 0.096 0.167679373172 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.89E-05 0 0
N/S 17530 Fn3-15 61 rs762214300 0.0701 -0.373 0.027 N 0.485 0.096 0.167679373172 gnomAD-4.0.0 4.34203E-05 None None None None N None 0 5.01052E-05 None 0 0 None 1.56426E-04 0 4.66457E-05 0 3.20677E-05
T/A 17630 Fn3-16 62 rs1384115571 0.1011 -0.647 0.977 N 0.441 0.419 0.38242337071 gnomAD-2.1.1 8.04E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.88E-06 0
T/A 17630 Fn3-16 62 rs1384115571 0.1011 -0.647 0.977 N 0.441 0.419 0.38242337071 gnomAD-4.0.0 4.77814E-06 None None None None N None 0 2.28739E-05 None 0 0 None 0 0 0 0 6.05583E-05
T/I 17630 Fn3-16 62 None 0.1385 None 0.235 N 0.299 0.363 0.421184727016 gnomAD-4.0.0 6.84481E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65782E-05
T/N 17630 Fn3-16 62 rs774179004 0.2094 -0.56 0.999 N 0.606 0.427 0.453024522228 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
T/N 17630 Fn3-16 62 rs774179004 0.2094 -0.56 0.999 N 0.606 0.427 0.453024522228 gnomAD-4.0.0 2.73793E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.63811E-05 0
L/P 17923 Fn3-18 62 None 0.2245 None 0.004 N 0.483 0.297 0.534668972696 gnomAD-4.0.0 1.59428E-06 None None None None N None 0 0 None 0 0 None 1.88267E-05 0 0 0 0
L/R 17923 Fn3-18 62 rs2054576322 0.1334 None 0.681 N 0.623 0.221 0.560642594899 gnomAD-4.0.0 1.11599E-05 None None None None N None 0 0 None 0 1.94563E-04 None 0 0 0 0 0
G/A 18127 Fn3-19 63 rs371971395 0.3208 0.374 0.999 N 0.573 0.324 None gnomAD-2.1.1 7.29E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.58E-05 0
G/A 18127 Fn3-19 63 rs371971395 0.3208 0.374 0.999 N 0.573 0.324 None gnomAD-3.1.2 1.32E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 1.47E-05 0 0
G/A 18127 Fn3-19 63 rs371971395 0.3208 0.374 0.999 N 0.573 0.324 None gnomAD-4.0.0 1.87025E-05 None None None None N None 1.34488E-05 0 None 0 0 None 0 0 2.04224E-05 0 8.05906E-05
V/A 18335 Fn3-21 64 None 0.1727 None 0.91 N 0.439 0.162 0.52437609879 gnomAD-4.0.0 1.59337E-06 None None None None N None 5.67279E-05 0 None 0 0 None 0 0 0 0 0
V/A 18539 Fn3-22 61 rs573082979 0.2692 -1.143 0.174 N 0.501 0.191 0.432493127443 gnomAD-2.1.1 6.86E-05 None None None None N None 0 0 None 0 0 None 5.55919E-04 None 0 0 0
V/A 18539 Fn3-22 61 rs573082979 0.2692 -1.143 0.174 N 0.501 0.191 0.432493127443 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 0 6.21118E-04 0
V/A 18539 Fn3-22 61 rs573082979 0.2692 -1.143 0.174 N 0.501 0.191 0.432493127443 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
V/A 18539 Fn3-22 61 rs573082979 0.2692 -1.143 0.174 N 0.501 0.191 0.432493127443 gnomAD-4.0.0 2.79017E-05 None None None None N None 0 0 None 0 0 None 0 0 0 4.72569E-04 3.20297E-05
V/I 18539 Fn3-22 61 rs1060500557 0.076 None 0.003 N 0.28 0.058 None gnomAD-4.0.0 1.36924E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79962E-06 0 0
T/M 18845 Fn3-24 62 rs371571153 0.097 -0.032 0.98 N 0.505 0.35 None gnomAD-2.1.1 5.71E-05 None None None None N None 4.24E-05 7.3E-05 None 0 2.8112E-04 None 8.79E-05 None 0 3.43E-05 0
T/M 18845 Fn3-24 62 rs371571153 0.097 -0.032 0.98 N 0.505 0.35 None gnomAD-3.1.2 5.26E-05 None None None None N None 2.41E-05 1.96721E-04 1.0989E-03 0 5.84795E-04 None 0 0 0 0 0
T/M 18845 Fn3-24 62 rs371571153 0.097 -0.032 0.98 N 0.505 0.35 None 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
T/M 18845 Fn3-24 62 rs371571153 0.097 -0.032 0.98 N 0.505 0.35 None gnomAD-4.0.0 2.66673E-05 None None None None N None 2.73643E-05 1.36282E-04 None 0 5.17878E-04 None 0 0 6.00287E-06 2.42642E-05 0
T/P 18845 Fn3-24 62 rs375000725 0.1787 -0.408 0.004 N 0.328 0.271 None gnomAD-2.1.1 7.71E-05 None None None None N None 4.23E-05 3.63E-05 None 0 0 None 0 None 0 1.45314E-04 0
T/P 18845 Fn3-24 62 rs375000725 0.1787 -0.408 0.004 N 0.328 0.271 None gnomAD-3.1.2 7.24E-05 None None None None N None 2.41E-05 1.31182E-04 0 0 0 None 0 0 1.17644E-04 0 0
T/P 18845 Fn3-24 62 rs375000725 0.1787 -0.408 0.004 N 0.328 0.271 None gnomAD-4.0.0 4.50264E-05 None None None None N None 1.36881E-05 7.75494E-05 None 0 0 None 0 0 5.22672E-05 0 8.20722E-05
K/E 18949 Fn3-25 66 None 0.3882 None 0.454 N 0.511 0.184 0.209622950755 gnomAD-4.0.0 1.5922E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8599E-06 0 0
V/I 19049 Fn3-26 62 rs750251277 0.0928 -0.098 0.997 N 0.478 0.256 0.608695890411 gnomAD-2.1.1 8.04E-05 None None None None N None 0 5.80114E-04 None 0 0 None 0 None 0 0 0
V/I 19049 Fn3-26 62 rs750251277 0.0928 -0.098 0.997 N 0.478 0.256 0.608695890411 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
V/I 19049 Fn3-26 62 rs750251277 0.0928 -0.098 0.997 N 0.478 0.256 0.608695890411 gnomAD-4.0.0 3.07683E-05 None None None None N None 0 4.06987E-04 None 0 0 None 0 0 0 0 0
T/P 19244 Fn3-27 62 rs796304694 0.2422 -0.476 0.859 N 0.649 0.332 0.369309618794 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
T/P 19244 Fn3-27 62 rs796304694 0.2422 -0.476 0.859 N 0.649 0.332 0.369309618794 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/P 19244 Fn3-27 62 rs796304694 0.2422 -0.476 0.859 N 0.649 0.332 0.369309618794 gnomAD-4.0.0 2.49655E-06 None None None None N None 0 0 None 0 0 None 0 0 3.40715E-06 0 0
T/A 19345 Fn3-28 62 rs567680958 0.1219 -0.875 0.726 N 0.52 0.406 0.266843984389 gnomAD-2.1.1 3.62E-05 None None None None N None 0 0 None 0 0 None 2.9431E-04 None 0 0 0
T/A 19345 Fn3-28 62 rs567680958 0.1219 -0.875 0.726 N 0.52 0.406 0.266843984389 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
T/A 19345 Fn3-28 62 rs567680958 0.1219 -0.875 0.726 N 0.52 0.406 0.266843984389 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
T/A 19345 Fn3-28 62 rs567680958 0.1219 -0.875 0.726 N 0.52 0.406 0.266843984389 gnomAD-4.0.0 1.17765E-05 None None None None N None 0 0 None 0 0 None 0 0 0 2.08672E-04 0
T/I 19345 Fn3-28 62 rs551040385 0.165 0.3 0.989 N 0.719 0.489 0.533276065955 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
T/I 19345 Fn3-28 62 rs551040385 0.165 0.3 0.989 N 0.719 0.489 0.533276065955 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 19345 Fn3-28 62 rs551040385 0.165 0.3 0.989 N 0.719 0.489 0.533276065955 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
T/I 19345 Fn3-28 62 rs551040385 0.165 0.3 0.989 N 0.719 0.489 0.533276065955 gnomAD-4.0.0 6.57212E-06 None None None None N None 2.40732E-05 0 None 0 0 None 0 0 0 0 0
T/N 19345 Fn3-28 62 rs551040385 0.2157 None 0.957 N 0.596 0.453 0.448300063881 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
K/I 19540 Fn3-29 62 rs2050741869 0.624 None 1.0 N 0.812 0.339 0.574056412462 gnomAD-4.0.0 1.59229E-06 None None None None N None 0 0 None 0 2.7835E-05 None 0 0 0 0 0
R/G 19640 Fn3-30 62 rs758745272 0.4502 -1.392 0.351 N 0.485 0.227 0.411799315854 gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 0 None 0 None 7.99E-05 7.81E-06 0
R/G 19640 Fn3-30 62 rs758745272 0.4502 -1.392 0.351 N 0.485 0.227 0.411799315854 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 1.88466E-04 0 0 0 0
R/G 19640 Fn3-30 62 rs758745272 0.4502 -1.392 0.351 N 0.485 0.227 0.411799315854 gnomAD-4.0.0 8.97192E-06 None None None None N None 0 0 None 0 0 None 7.84511E-05 0 2.39407E-06 0 2.84511E-05
F/S 19937 Fn3-32 61 rs2050339836 0.2076 None 0.014 N 0.297 0.087 0.385249989106 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 1.01626E-03 None 0 0 None 0 0 0 0 0
R/G 20331 Fn3-35 61 rs1226541281 0.6987 -1.096 None N 0.366 0.147 0.243398259712 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
R/G 20331 Fn3-35 61 rs1226541281 0.6987 -1.096 None N 0.366 0.147 0.243398259712 gnomAD-4.0.0 1.5952E-06 None None None None N None 0 0 None 0 2.77901E-05 None 0 0 0 0 0
R/M 20433 Fn3-36 63 rs1475658626 0.526 None 0.963 N 0.571 0.357 0.433047596574 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/M 20433 Fn3-36 63 rs1475658626 0.526 None 0.963 N 0.571 0.357 0.433047596574 gnomAD-4.0.0 6.5767E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47119E-05 0 0
I/V 20628 Fn3-37 60 rs778583635 0.0826 -0.711 None N 0.195 0.078 0.316788114976 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
I/V 20628 Fn3-37 60 rs778583635 0.0826 -0.711 None N 0.195 0.078 0.316788114976 gnomAD-4.0.0 1.59194E-06 None None None None N None 0 0 None 0 2.77855E-05 None 0 0 0 0 0
M/I 20729 Fn3-38 62 None 0.5457 None 0.003 N 0.193 0.173 0.554640639675 gnomAD-4.0.0 1.59214E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02535E-05
M/V 20729 Fn3-38 62 None 0.1381 None 0.021 N 0.297 0.164 0.525767821325 gnomAD-4.0.0 1.59209E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85917E-06 0 0
T/I 20924 Fn3-39 61 rs1213561769 0.0993 -0.136 0.166 N 0.375 0.194 0.291694819147 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
T/I 20924 Fn3-39 61 rs1213561769 0.0993 -0.136 0.166 N 0.375 0.194 0.291694819147 gnomAD-4.0.0 2.73884E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79946E-06 2.31981E-05 0
T/R 20924 Fn3-39 61 rs1213561769 0.1587 -0.258 0.166 N 0.397 0.231 0.326881540566 gnomAD-2.1.1 8.1E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
T/R 20924 Fn3-39 61 rs1213561769 0.1587 -0.258 0.166 N 0.397 0.231 0.326881540566 gnomAD-4.0.0 4.79298E-06 None None None None N None 0 0 None 0 0 None 0 0 6.2981E-06 0 0
H/L 21326 Fn3-42 61 None 0.07 None 0.003 N 0.356 0.199 0.312001716656 gnomAD-4.0.0 6.84428E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99688E-07 0 0
H/P 21326 Fn3-42 61 None 0.1023 None 0.013 N 0.35 0.197 0.227260227426 gnomAD-4.0.0 6.84428E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99688E-07 0 0
H/R 21326 Fn3-42 61 rs994982613 0.0818 -0.574 None N 0.077 0.15 0.171388866994 gnomAD-2.1.1 1.43E-05 None None None None N None 1.24028E-04 0 None 0 0 None 0 None 0 7.83E-06 0
H/R 21326 Fn3-42 61 rs994982613 0.0818 -0.574 None N 0.077 0.15 0.171388866994 gnomAD-3.1.2 3.95E-05 None None None None N None 1.20656E-04 0 0 0 0 None 0 0 1.47E-05 0 0
H/R 21326 Fn3-42 61 rs994982613 0.0818 -0.574 None N 0.077 0.15 0.171388866994 gnomAD-4.0.0 1.23984E-05 None None None None N None 1.20205E-04 0 None 0 0 None 0 1.64582E-04 4.23922E-06 0 8.01077E-05
H/Y 21326 Fn3-42 61 rs1413306492 0.0918 1.103 0.013 N 0.379 0.064 0.132336055621 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 1.65728E-04
H/Y 21326 Fn3-42 61 rs1413306492 0.0918 1.103 0.013 N 0.379 0.064 0.132336055621 gnomAD-4.0.0 4.77731E-06 None None None None N None 0 0 None 0 0 None 0 4.83092E-04 0 1.43291E-05 0
R/K 21620 Fn3-44 62 rs776516784 0.1771 -0.101 0.997 N 0.506 0.337 0.355242300401 gnomAD-2.1.1 2.42E-05 None None None None N None 0 1.73873E-04 None 0 0 None 0 None 0 0 0
R/K 21620 Fn3-44 62 rs776516784 0.1771 -0.101 0.997 N 0.506 0.337 0.355242300401 gnomAD-4.0.0 9.55122E-06 None None None None N None 0 1.37212E-04 None 0 0 None 0 0 0 0 0
R/S 21620 Fn3-44 62 rs373713828 0.8819 -0.327 1.0 N 0.787 0.336 0.283761946502 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
R/S 21620 Fn3-44 62 rs373713828 0.8819 -0.327 1.0 N 0.787 0.336 0.283761946502 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.44E-05 0 0 0 0
R/S 21620 Fn3-44 62 rs373713828 0.8819 -0.327 1.0 N 0.787 0.336 0.283761946502 gnomAD-4.0.0 6.84321E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99612E-07 0 0
P/T 21720 Fn3-45 62 rs776953525 0.2671 -0.97 0.198 N 0.318 0.268 0.339555952218 gnomAD-2.1.1 2.42E-05 None None None None N None 0 0 None 0 0 None 0 None 0 5.35E-05 0
P/T 21720 Fn3-45 62 rs776953525 0.2671 -0.97 0.198 N 0.318 0.268 0.339555952218 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
P/T 21720 Fn3-45 62 rs776953525 0.2671 -0.97 0.198 N 0.318 0.268 0.339555952218 gnomAD-4.0.0 1.15367E-05 None None None None N None 1.69222E-05 0 None 0 0 None 0 0 1.91566E-05 0 0
T/I 21820 Fn3-46 64 rs56130023 0.128 -0.088 0.134 N 0.347 0.302 None gnomAD-2.1.1 9.87908E-04 None None None None N None 1.28855E-03 4.26524E-04 None 1.6738E-02 0 None 3.29E-05 None 0 3.22079E-04 2.12465E-03
T/I 21820 Fn3-46 64 rs56130023 0.128 -0.088 0.134 N 0.347 0.302 None gnomAD-3.1.2 7.82462E-04 None None None None N None 1.01351E-03 2.62261E-04 0 1.4977E-02 0 None 0 0 2.20595E-04 0 2.86807E-03
T/I 21820 Fn3-46 64 rs56130023 0.128 -0.088 0.134 N 0.347 0.302 None 1000 genomes 1.19808E-03 None None None None N None 4.5E-03 0 None None 0 0 None None None 0 None
T/I 21820 Fn3-46 64 rs56130023 0.128 -0.088 0.134 N 0.347 0.302 None gnomAD-4.0.0 5.99741E-04 None None None None N None 1.36025E-03 4.17376E-04 None 1.67501E-02 0 None 0 3.63757E-03 1.76394E-04 1.10018E-05 1.82739E-03
S/I 22016 Fn3-47 61 rs1424506370 0.1237 0.311 0.062 N 0.524 0.113 0.1749357433 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/I 22016 Fn3-47 61 rs1424506370 0.1237 0.311 0.062 N 0.524 0.113 0.1749357433 gnomAD-4.0.0 1.59316E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43365E-05 0
E/D 22218 Fn3-49 63 rs1210761677 0.2987 -0.32 None N 0.223 0.083 0.0666544352282 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
E/D 22218 Fn3-49 63 rs1210761677 0.2987 -0.32 None N 0.223 0.083 0.0666544352282 gnomAD-4.0.0 7.96772E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72433E-06 0 9.09146E-05
E/V 22218 Fn3-49 63 rs2047762977 0.1286 None None N 0.267 0.203 0.32980341726 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.42E-05 0 0 0 0
E/V 22218 Fn3-49 63 rs2047762977 0.1286 None None N 0.267 0.203 0.32980341726 gnomAD-4.0.0 6.57739E-06 None None None None N None 0 0 None 0 0 None 9.41797E-05 0 0 0 0
R/S 22414 Fn3-50 61 rs761987832 0.7445 -1.198 0.892 N 0.684 0.233 0.252681307341 gnomAD-2.1.1 8.05E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 8.9E-06 0
R/S 22414 Fn3-50 61 rs761987832 0.7445 -1.198 0.892 N 0.684 0.233 0.252681307341 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/S 22414 Fn3-50 61 rs761987832 0.7445 -1.198 0.892 N 0.684 0.233 0.252681307341 gnomAD-4.0.0 1.36877E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79936E-06 0 0
S/P 22509 Fn3-51 59 None 0.2773 None 0.484 N 0.547 0.214 0.235038932564 gnomAD-4.0.0 1.59222E-06 None None None None N None 0 0 None 0 2.77778E-05 None 0 0 0 0 0
R/G 22704 Fn3-52 62 rs1393414222 0.8213 -0.596 0.805 N 0.604 0.315 0.468168183122 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/G 22704 Fn3-52 62 rs1393414222 0.8213 -0.596 0.805 N 0.604 0.315 0.468168183122 gnomAD-4.0.0 1.59222E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43291E-05 0
R/K 22704 Fn3-52 62 rs773477768 0.2086 -0.094 0.773 N 0.556 0.215 0.277730125212 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/K 22704 Fn3-52 62 rs773477768 0.2086 -0.094 0.773 N 0.556 0.215 0.277730125212 gnomAD-4.0.0 1.59222E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43291E-05 0
V/A 23100 Fn3-55 61 None 0.2406 None 0.014 N 0.231 0.142 0.434045841721 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/E 23200 Fn3-56 62 rs1256094909 0.7851 None 0.958 N 0.54 0.297 0.231873229951 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/E 23200 Fn3-56 62 rs1256094909 0.7851 None 0.958 N 0.54 0.297 0.231873229951 gnomAD-4.0.0 6.57505E-06 None None None None N None 2.4122E-05 0 None 0 0 None 0 0 0 0 0
K/N 23200 Fn3-56 62 None 0.919 None 0.988 N 0.681 0.279 0.17948927462 gnomAD-4.0.0 1.59158E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43291E-05 0
V/I 23302 Fn3-57 63 rs190421400 0.0957 -0.191 0.383 N 0.437 0.093 None gnomAD-2.1.1 1.50721E-04 None None None None I None 1.24121E-03 5.68E-05 None 0 1.55119E-04 None 6.56E-05 None 0 3.15E-05 1.41084E-04
V/I 23302 Fn3-57 63 rs190421400 0.0957 -0.191 0.383 N 0.437 0.093 None gnomAD-3.1.2 3.55128E-04 None None None None I None 1.18249E-03 0 0 0 0 None 0 0 7.35E-05 0 0
V/I 23302 Fn3-57 63 rs190421400 0.0957 -0.191 0.383 N 0.437 0.093 None 1000 genomes 7.98722E-04 None None None None I None 3E-03 0 None None 0 0 None None None 0 None
V/I 23302 Fn3-57 63 rs190421400 0.0957 -0.191 0.383 N 0.437 0.093 None gnomAD-4.0.0 7.75029E-05 None None None None I None 9.33582E-04 5.00684E-05 None 0 8.94374E-05 None 0 0 2.11978E-05 4.39773E-05 3.04263E-04
K/E 23495 Fn3-58 61 None 0.3959 None 0.87 N 0.541 0.215 0.245101548738 gnomAD-4.0.0 3.18337E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86607E-05 0
K/N 23495 Fn3-58 61 rs1482776876 0.7114 -0.244 0.987 N 0.662 0.263 0.143124449307 gnomAD-2.1.1 2.01E-05 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 3.56E-05 0
K/N 23495 Fn3-58 61 rs1482776876 0.7114 -0.244 0.987 N 0.662 0.263 0.143124449307 gnomAD-4.0.0 1.437E-05 None None None None N None 2.98829E-05 0 None 0 0 None 0 0 1.52924E-05 0 4.97051E-05
K/E 23787 Fn3-60 62 None 0.9408 None 0.999 N 0.604 0.452 0.296329037015 gnomAD-4.0.0 8.40225E-06 None None None None I None 0 0 None 0 0 None 0 0 9.18751E-06 0 0
T/I 23985 Fn3-62 62 None 0.165 None 1.0 N 0.833 0.551 0.663365763907 gnomAD-4.0.0 2.73727E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59826E-06 0 0
T/R 23985 Fn3-62 62 None 0.2756 None 1.0 N 0.835 0.525 0.78875543026 gnomAD-4.0.0 6.84318E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99565E-07 0 0
K/N 24183 Fn3-63 62 None 0.7179 None 1.0 N 0.736 0.351 0.214338557667 gnomAD-4.0.0 7.43133E-07 None None None None N None 0 0 None 0 0 None 0 0 9.45035E-07 0 0
K/T 24183 Fn3-63 62 None 0.2887 None 1.0 N 0.823 0.358 0.340753184043 gnomAD-4.0.0 7.42424E-07 None None None None N None 0 0 None 0 0 None 0 0 9.44444E-07 0 0
K/N 24283 Fn3-64 62 None 0.9127 None 0.967 N 0.641 0.19 0.247322355667 gnomAD-4.0.0 1.64151E-06 None None None None N None 0 0 None 0 0 None 0 0 2.93474E-06 0 0
T/A 24385 Fn3-65 63 rs1403922674 0.1154 -0.765 0.025 N 0.281 0.253 0.294206760003 gnomAD-2.1.1 1.08E-05 None None None None N None 4.14E-05 0 None 0 0 None 0 None 0 1.57E-05 0
T/A 24385 Fn3-65 63 rs1403922674 0.1154 -0.765 0.025 N 0.281 0.253 0.294206760003 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
T/A 24385 Fn3-65 63 rs1403922674 0.1154 -0.765 0.025 N 0.281 0.253 0.294206760003 gnomAD-4.0.0 5.57937E-06 None None None None N None 1.33501E-05 0 None 0 0 None 0 0 6.78243E-06 0 0
T/S 24675 Fn3-67 60 rs1553606008 0.1183 None 0.006 N 0.263 0.227 0.186928172975 gnomAD-4.0.0 1.59264E-06 None None None None I None 0 2.28739E-05 None 0 0 None 0 0 0 0 0
K/N 24869 Fn3-68 62 rs1708181075 0.9853 None 0.988 N 0.698 0.272 0.203808441222 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.78011E-04
K/N 24869 Fn3-68 62 rs1708181075 0.9853 None 0.988 N 0.698 0.272 0.203808441222 gnomAD-4.0.0 6.5767E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 4.78011E-04
K/N 24969 Fn3-69 62 rs1708070929 0.7412 None 0.988 N 0.675 0.254 0.158396225186 gnomAD-4.0.0 3.18353E-06 None None None None N None 0 0 None 0 0 None 1.88267E-05 0 0 0 3.02517E-05
K/N 25265 Fn3-71 62 None 0.8073 None 0.967 N 0.615 0.273 0.184867976434 gnomAD-4.0.0 6.84426E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99596E-07 0 0
R/G 25365 Fn3-72 62 None 0.8021 None 0.008 N 0.391 0.184 0.421550847248 gnomAD-4.0.0 1.59223E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43303E-05 0
R/K 25365 Fn3-72 62 None 0.1266 None 0.008 N 0.227 0.073 0.0762999501168 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 25467 Fn3-73 63 rs758729188 0.1194 -0.084 0.014 N 0.347 0.175 0.21737058555 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
E/K 25467 Fn3-73 63 rs758729188 0.1194 -0.084 0.014 N 0.347 0.175 0.21737058555 gnomAD-4.0.0 1.27406E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.00333E-04 3.02755E-05
V/A 25757 Fn3-75 60 rs888818269 0.1739 None 0.472 N 0.437 0.129 0.520694202979 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/A 25757 Fn3-75 60 rs888818269 0.1739 None 0.472 N 0.437 0.129 0.520694202979 gnomAD-4.0.0 1.85984E-06 None None None None N None 4.00598E-05 0 None 0 0 None 0 0 0 0 0
V/E 25757 Fn3-75 60 None 0.2047 None 0.007 N 0.441 0.255 0.648112553962 gnomAD-4.0.0 6.84488E-07 None None None None N None 0 0 None 3.82907E-05 0 None 0 0 0 0 0
V/L 25757 Fn3-75 60 rs1307639752 0.1666 0.011 0.007 N 0.255 0.088 0.415820034956 gnomAD-4.0.0 1.59281E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85953E-06 0 0
T/S 26149 Fn3-78 62 rs191263181 0.1501 -0.779 0.822 N 0.47 0.376 0.21737058555 gnomAD-2.1.1 8.61E-05 None None None None N None 7.85838E-04 1.13572E-04 None 0 0 None 0 None 0 0 1.41403E-04
T/S 26149 Fn3-78 62 rs191263181 0.1501 -0.779 0.822 N 0.47 0.376 0.21737058555 gnomAD-3.1.2 2.16945E-04 None None None None N None 7.72275E-04 0 0 0 0 None 0 0 0 0 4.78011E-04
T/S 26149 Fn3-78 62 rs191263181 0.1501 -0.779 0.822 N 0.47 0.376 0.21737058555 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
T/S 26149 Fn3-78 62 rs191263181 0.1501 -0.779 0.822 N 0.47 0.376 0.21737058555 gnomAD-4.0.0 4.40428E-05 None None None None N None 7.86814E-04 8.34307E-05 None 0 0 None 0 0 8.48456E-07 0 9.61477E-05
R/G 26447 Fn3-80 62 None 0.9475 None 0.892 N 0.637 0.358 0.539567288477 gnomAD-4.0.0 1.59217E-06 None None None None N None 0 0 None 0 2.77624E-05 None 0 0 0 0 0
R/K 26447 Fn3-80 62 None 0.2812 None 0.025 N 0.308 0.143 0.202086224978 gnomAD-4.0.0 4.77661E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71762E-06 0 3.02572E-05
K/T 26743 Fn3-82 61 rs368263400 0.2926 -0.904 0.097 N 0.489 0.135 0.170165803431 gnomAD-2.1.1 8.04E-05 None None None None N None 0 0 None 0 2.23065E-04 None 3.92182E-04 None 0 3.56E-05 0
K/T 26743 Fn3-82 61 rs368263400 0.2926 -0.904 0.097 N 0.489 0.135 0.170165803431 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 3.861E-04 None 0 0 1.47E-05 0 0
K/T 26743 Fn3-82 61 rs368263400 0.2926 -0.904 0.097 N 0.489 0.135 0.170165803431 gnomAD-4.0.0 2.7269E-05 None None None None N None 0 0 None 0 1.33767E-04 None 0 0 9.32458E-06 2.52525E-04 6.40533E-05
V/G 26839 Fn3-83 60 rs1157147648 0.2615 -0.367 0.549 D 0.569 0.268 0.758059979048 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
V/G 26839 Fn3-83 60 rs1157147648 0.2615 -0.367 0.549 D 0.569 0.268 0.758059979048 gnomAD-4.0.0 6.00161E-06 None None None None I None 0 0 None 0 0 None 0 0 6.56251E-06 0 0
V/I 26839 Fn3-83 60 rs879175711 0.0744 None 0.016 N 0.207 0.09 0.547126614516 gnomAD-4.0.0 2.05285E-06 None None None None I None 0 0 None 0 0 None 0 0 8.9957E-07 1.15937E-05 1.65706E-05
K/E 27133 Fn3-85 62 None 0.4886 None 0.014 N 0.338 0.189 0.24896430686 gnomAD-4.0.0 1.59287E-06 None None None None N None 0 2.29043E-05 None 0 0 None 0 0 0 0 0
K/R 27133 Fn3-85 62 None 0.0826 None 0.014 N 0.213 0.065 0.183819452728 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 27231 Fn3-86 62 rs1704907132 0.14 None 0.983 N 0.674 0.437 0.561867705733 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
T/I 27231 Fn3-86 62 rs1704907132 0.14 None 0.983 N 0.674 0.437 0.561867705733 gnomAD-4.0.0 1.8604E-06 None None None None I None 0 0 None 0 0 None 0 0 1.69598E-06 1.09866E-05 0
K/N 27430 Fn3-87 62 None 0.9193 None 1.0 N 0.73 0.308 0.191931220699 gnomAD-4.0.0 1.59134E-06 None None None None N None 0 0 None 0 2.775E-05 None 0 0 0 0 0
K/R 27430 Fn3-87 62 None 0.1058 None 0.999 N 0.514 0.336 0.243398259712 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/K 27530 Fn3-88 62 None 0.1841 None 0.997 N 0.544 0.324 0.344483371355 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/T 27530 Fn3-88 62 None 0.7194 None 1.0 N 0.745 0.343 0.399017061211 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
T/I 27632 Fn3-89 63 rs1229009880 0.1329 -0.204 1.0 N 0.713 0.533 0.577830415381 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.65837E-04
T/I 27632 Fn3-89 63 rs1229009880 0.1329 -0.204 1.0 N 0.713 0.533 0.577830415381 gnomAD-4.0.0 1.36849E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99517E-07 1.15934E-05 0
T/R 27632 Fn3-89 63 None 0.2309 None 0.999 N 0.701 0.476 0.67760892679 gnomAD-4.0.0 6.84243E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99517E-07 0 0
T/S 27632 Fn3-89 63 rs748765738 0.1732 -0.405 0.998 N 0.403 0.42 0.277317399466 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
T/S 27632 Fn3-89 63 rs748765738 0.1732 -0.405 0.998 N 0.403 0.42 0.277317399466 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
E/G 28313 Fn3-94 62 rs896539539 0.4367 None 0.801 N 0.563 0.246 0.357929162469 gnomAD-4.0.0 1.59184E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85809E-06 0 0
K/N 28511 Fn3-95 62 None 0.5962 None 1.0 N 0.725 0.32 0.193865811164 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/N 28905 Fn3-98 61 None 0.7255 None 0.308 N 0.325 0.098 0.148003135375 gnomAD-4.0.0 1.59147E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85894E-06 0 0
K/R 28905 Fn3-98 61 rs764838711 0.0752 -0.011 0.919 N 0.527 0.216 None gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
K/R 28905 Fn3-98 61 rs764838711 0.0752 -0.011 0.919 N 0.527 0.216 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/R 28905 Fn3-98 61 rs764838711 0.0752 -0.011 0.919 N 0.527 0.216 None gnomAD-4.0.0 2.56248E-06 None None None None N None 1.69147E-05 0 None 0 0 None 0 0 2.39354E-06 0 0
V/I 29001 Fn3-99 60 rs750591986 0.0661 -0.218 0.001 N 0.177 0.061 0.201204373187 gnomAD-2.1.1 2.86E-05 None None None None N None 4.13E-05 2.83E-05 None 9.68E-05 0 None 0 None 0 3.91E-05 0
V/I 29001 Fn3-99 60 rs750591986 0.0661 -0.218 0.001 N 0.177 0.061 0.201204373187 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/I 29001 Fn3-99 60 rs750591986 0.0661 -0.218 0.001 N 0.177 0.061 0.201204373187 gnomAD-4.0.0 1.11547E-05 None None None None N None 1.33461E-05 3.33522E-05 None 6.75676E-05 0 None 0 0 1.10184E-05 0 0
K/E 29198 Fn3-100 62 None 0.8462 None 0.939 N 0.487 0.269 0.322510055762 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
K/R 29198 Fn3-100 62 rs542970665 0.099 -0.189 0.046 N 0.244 0.121 0.305730143919 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/R 29198 Fn3-100 62 rs542970665 0.099 -0.189 0.046 N 0.244 0.121 0.305730143919 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
K/R 29198 Fn3-100 62 rs542970665 0.099 -0.189 0.046 N 0.244 0.121 0.305730143919 gnomAD-4.0.0 6.56452E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
K/T 29198 Fn3-100 62 None 0.6936 None 0.991 N 0.729 0.302 0.300449992093 gnomAD-4.0.0 4.8013E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25002E-06 0 0
I/T 29396 Fn3-102 62 rs9808377 0.0487 -0.711 None N 0.149 0.124 None gnomAD-2.1.1 3.50522E-01 None None None None I None 5.42256E-01 4.23746E-01 None 2.78498E-01 7.02878E-01 None 5.14548E-01 None 2.76288E-01 2.24288E-01 3.04806E-01
I/T 29396 Fn3-102 62 rs9808377 0.0487 -0.711 None N 0.149 0.124 None gnomAD-3.1.2 3.60337E-01 None None None None I None 5.41715E-01 3.81193E-01 5.62637E-01 2.82421E-01 6.98952E-01 None 2.84864E-01 2.73885E-01 2.23289E-01 5.15346E-01 3.25837E-01
I/T 29396 Fn3-102 62 rs9808377 0.0487 -0.711 None N 0.149 0.124 None 1000 genomes 5.07188E-01 None None None None I None 5.666E-01 4.049E-01 None None 7.153E-01 2.495E-01 None None None 5.501E-01 None
I/T 29396 Fn3-102 62 rs9808377 0.0487 -0.711 None N 0.149 0.124 None gnomAD-4.0.0 2.75309E-01 None None None None I None 5.47996E-01 4.12577E-01 None 2.79358E-01 6.93195E-01 None 2.78052E-01 3.04886E-01 2.15479E-01 5.03712E-01 3.02279E-01
K/E 29694 Fn3-104 62 rs1222832366 0.6584 0.31 0.996 N 0.479 0.291 0.317084106153 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 1.11321E-04 None 0 None 0 0 0
K/E 29694 Fn3-104 62 rs1222832366 0.6584 0.31 0.996 N 0.479 0.291 0.317084106153 gnomAD-4.0.0 1.59134E-06 None None None None N None 0 0 None 0 2.77285E-05 None 0 0 0 0 0
K/N 29694 Fn3-104 62 None 0.7969 None 0.999 N 0.668 0.18 0.144782658237 gnomAD-4.0.0 1.59139E-06 None None None None N None 0 0 None 0 2.77285E-05 None 0 0 0 0 0
V/M 29796 Fn3-105 63 rs72648237 0.2419 -0.291 1.0 N 0.701 0.252 None gnomAD-2.1.1 1.18939E-03 None None None None N None 1.23946E-04 5.93891E-04 None 3.29075E-03 0 None 5.45823E-03 None 0 7.35294E-04 1.96629E-03
V/M 29796 Fn3-105 63 rs72648237 0.2419 -0.291 1.0 N 0.701 0.252 None gnomAD-3.1.2 7.55704E-04 None None None None N None 2.65354E-04 6.54793E-04 0 3.45622E-03 0 None 0 3.16456E-03 8.5269E-04 3.10302E-03 3.83142E-03
V/M 29796 Fn3-105 63 rs72648237 0.2419 -0.291 1.0 N 0.701 0.252 None 1000 genomes 9.98403E-04 None None None None N None 0 1.4E-03 None None 0 2E-03 None None None 2E-03 None
V/M 29796 Fn3-105 63 rs72648237 0.2419 -0.291 1.0 N 0.701 0.252 None gnomAD-4.0.0 9.64759E-04 None None None None N None 1.73218E-04 7.16476E-04 None 3.44595E-03 0 None 0 8.25355E-04 7.19615E-04 5.08322E-03 1.31246E-03
K/R 29993 Fn3-106 61 rs1322969533 0.0806 None 0.999 N 0.56 0.223 0.388970301349 gnomAD-3.1.2 2.63E-05 None None None None N None 0 2.62055E-04 0 0 0 None 0 0 0 0 0
K/R 29993 Fn3-106 61 rs1322969533 0.0806 None 0.999 N 0.56 0.223 0.388970301349 gnomAD-4.0.0 5.07491E-06 None None None None N None 0 3.0773E-04 None 0 0 None 0 0 0 0 0
E/D 30089 Fn3-107 60 rs1290870091 0.2167 None 0.674 N 0.473 0.087 0.272205846399 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/D 30089 Fn3-107 60 rs1290870091 0.2167 None 0.674 N 0.473 0.087 0.272205846399 gnomAD-4.0.0 1.59104E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02371E-05
E/K 30089 Fn3-107 60 rs377281790 0.1604 None 0.674 N 0.514 0.194 0.302793454619 gnomAD-4.0.0 3.42083E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.15937E-05 6.62581E-05
E/Q 30089 Fn3-107 60 None 0.129 None 0.957 N 0.567 0.235 0.361160317528 gnomAD-4.0.0 6.84167E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15937E-05 0
R/T 30385 Fn3-109 62 rs780885701 0.6057 -0.431 1.0 N 0.77 0.396 0.389126455913 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 1.11383E-04 None 0 None 0 0 0
R/T 30385 Fn3-109 62 rs780885701 0.6057 -0.431 1.0 N 0.77 0.396 0.389126455913 gnomAD-4.0.0 3.18249E-06 None None None None N None 0 0 None 0 5.54631E-05 None 0 0 0 0 0
T/A 30482 Fn3-110 61 None 0.1276 None 0.999 N 0.555 0.566 0.3691244813 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
T/K 30482 Fn3-110 61 rs1219629332 0.3309 -0.371 1.0 N 0.835 0.46 0.45882554386 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 6.42674E-04 None 0 None 0 0 0
T/K 30482 Fn3-110 61 rs1219629332 0.3309 -0.371 1.0 N 0.835 0.46 0.45882554386 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92827E-04 None 0 0 0 0 0
T/K 30482 Fn3-110 61 rs1219629332 0.3309 -0.371 1.0 N 0.835 0.46 0.45882554386 gnomAD-4.0.0 6.57315E-06 None None None None N None 0 0 None 0 1.92827E-04 None 0 0 0 0 0
T/I 30680 Fn3-111 62 None 0.169 None 0.966 N 0.516 0.346 0.347879110917 gnomAD-4.0.0 1.59131E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85845E-06 0 0
T/N 30680 Fn3-111 62 rs2154148406 0.1292 None 0.005 N 0.2 0.099 0.194818534648 gnomAD-4.0.0 3.18262E-06 None None None None N None 0 0 None 0 5.54754E-05 None 0 0 0 0 0
T/P 30680 Fn3-111 62 rs1206813558 0.1854 -0.497 0.989 N 0.517 0.482 0.377451072189 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/P 30680 Fn3-111 62 rs1206813558 0.1854 -0.497 0.989 N 0.517 0.482 0.377451072189 gnomAD-4.0.0 1.59132E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
T/R 30882 Fn3-113 62 None 0.2664 None 0.241 N 0.32 0.286 0.388174495139 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62502E-06 0 0
K/Q 31076 Fn3-114 61 rs778813590 0.2002 -0.208 0.22 N 0.565 0.185 0.200317383148 gnomAD-2.1.1 8.06E-06 None None None None N None 1.29266E-04 0 None 0 0 None 0 None 0 0 0
K/Q 31076 Fn3-114 61 rs778813590 0.2002 -0.208 0.22 N 0.565 0.185 0.200317383148 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
K/Q 31076 Fn3-114 61 rs778813590 0.2002 -0.208 0.22 N 0.565 0.185 0.200317383148 gnomAD-4.0.0 1.31461E-05 None None None None N None 4.82602E-05 0 None 0 0 None 0 0 0 0 0
K/R 31076 Fn3-114 61 rs1186129682 0.0672 -0.145 None N 0.171 0.095 0.242825505644 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.65782E-04
K/R 31076 Fn3-114 61 rs1186129682 0.0672 -0.145 None N 0.171 0.095 0.242825505644 gnomAD-4.0.0 1.59114E-06 None None None None N None 0 0 None 0 0 None 0 2.4108E-04 0 0 0
T/I 31172 Fn3-115 60 None 0.1022 None 0.704 N 0.464 0.331 0.459100921832 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/R 31172 Fn3-115 60 None 0.1326 None 0.996 N 0.557 0.405 0.701366418672 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
T/A 31570 Fn3-118 65 rs1697325593 0.211 None 0.999 N 0.609 0.484 0.349429436713 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
V/F 31768 Fn3-119 61 None 0.3297 None 0.995 N 0.687 0.321 0.745290931308 gnomAD-4.0.0 1.36839E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79892E-06 0 0
V/L 31768 Fn3-119 61 rs1696890603 0.3038 None 0.78 N 0.522 0.19 0.330331372229 gnomAD-4.0.0 1.36839E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79892E-06 0 0
R/G 32165 Fn3-122 61 rs768216478 0.5938 -1.117 1.0 N 0.706 0.444 0.489449420884 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.91E-06 0
R/G 32165 Fn3-122 61 rs768216478 0.5938 -1.117 1.0 N 0.706 0.444 0.489449420884 gnomAD-4.0.0 4.10541E-06 None None None None N None 0 0 None 0 0 None 0 1.7337E-04 1.79895E-06 3.47802E-05 0
R/T 32165 Fn3-122 61 None 0.4211 None 1.0 N 0.749 0.407 0.51196500227 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 32263 Fn3-123 62 rs762871001 0.1702 0.205 0.612 N 0.276 0.382 0.38225645794 gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
T/I 32263 Fn3-123 62 rs762871001 0.1702 0.205 0.612 N 0.276 0.382 0.38225645794 gnomAD-4.0.0 1.36849E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99515E-07 1.15934E-05 0
T/N 32263 Fn3-123 62 None 0.2304 None 0.996 N 0.623 0.387 0.404034981753 gnomAD-4.0.0 6.84244E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99515E-07 0 0
T/S 32263 Fn3-123 62 rs762871001 0.1535 -1.021 0.956 N 0.397 0.424 0.245660935333 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/S 32263 Fn3-123 62 rs762871001 0.1535 -1.021 0.956 N 0.397 0.424 0.245660935333 gnomAD-4.0.0 6.84244E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
K/E 32460 Fn3-124 62 rs965156924 0.8793 None 0.996 N 0.538 0.344 0.292787519742 gnomAD-3.1.2 4.6E-05 None None None None N None 1.69E-04 0 0 0 0 None 0 0 0 0 0
K/E 32460 Fn3-124 62 rs965156924 0.8793 None 0.996 N 0.538 0.344 0.292787519742 gnomAD-4.0.0 4.60254E-05 None None None None N None 1.69E-04 0 None 0 0 None 0 0 0 0 0
R/C 32560 Fn3-125 62 rs760762257 0.4287 -0.736 1.0 N 0.795 0.361 0.614419055545 gnomAD-2.1.1 2.88E-05 None None None None I None 8.32E-05 0 None 0 1.55618E-04 None 0 None 0 1.57E-05 1.41123E-04
R/C 32560 Fn3-125 62 rs760762257 0.4287 -0.736 1.0 N 0.795 0.361 0.614419055545 gnomAD-3.1.2 4.6E-05 None None None None I None 4.83E-05 0 0 0 1.92976E-04 None 9.44E-05 0 4.41E-05 0 0
R/C 32560 Fn3-125 62 rs760762257 0.4287 -0.736 1.0 N 0.795 0.361 0.614419055545 gnomAD-4.0.0 2.29524E-05 None None None None I None 5.34416E-05 0 None 0 3.79871E-04 None 7.82742E-05 0 7.63294E-06 2.20629E-05 0
R/H 32560 Fn3-125 62 rs775600228 0.2465 -1.714 1.0 N 0.715 0.478 0.332902724076 gnomAD-2.1.1 8.12E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.79E-05 0
R/H 32560 Fn3-125 62 rs775600228 0.2465 -1.714 1.0 N 0.715 0.478 0.332902724076 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/H 32560 Fn3-125 62 rs775600228 0.2465 -1.714 1.0 N 0.715 0.478 0.332902724076 gnomAD-4.0.0 1.11673E-05 None None None None I None 0 3.3418E-05 None 0 0 None 1.56563E-05 0 8.48202E-06 3.31009E-05 3.20657E-05
T/I 32661 Fn3-126 62 rs1427043562 0.3564 None 1.0 N 0.836 0.429 0.60179161069 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 32661 Fn3-126 62 rs1427043562 0.3564 None 1.0 N 0.836 0.429 0.60179161069 gnomAD-4.0.0 6.57324E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47016E-05 0 0
V/L 32856 Fn3-127 62 rs1693334476 0.2842 None 0.997 N 0.491 0.285 0.475971816791 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/L 32856 Fn3-127 62 rs1693334476 0.2842 None 0.997 N 0.491 0.285 0.475971816791 gnomAD-4.0.0 6.57479E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46998E-05 0 0
T/I 32958 Fn3-128 63 rs1441902743 0.3081 -0.004 0.999 N 0.664 0.416 0.614010665196 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
T/I 32958 Fn3-128 63 rs1441902743 0.3081 -0.004 0.999 N 0.664 0.416 0.614010665196 gnomAD-4.0.0 1.36844E-06 None None None None N None 0 0 None 0 0 None 0 0 1.799E-06 0 0
T/S 32958 Fn3-128 63 rs1441902743 0.2362 None 0.989 N 0.438 0.316 0.31411915649 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/S 32958 Fn3-128 63 rs1441902743 0.2362 None 0.989 N 0.438 0.316 0.31411915649 gnomAD-4.0.0 6.8422E-07 None None None None N None 0 0 None 0 2.51915E-05 None 0 0 0 0 0
T/I 33059 Fn3-129 62 rs1038769207 0.1723 -0.22 0.235 N 0.339 0.302 0.427139414373 gnomAD-2.1.1 8.03E-06 None None None None N None 0 5.79E-05 None 0 0 None 0 None 0 0 0
T/I 33059 Fn3-129 62 rs1038769207 0.1723 -0.22 0.235 N 0.339 0.302 0.427139414373 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
T/I 33059 Fn3-129 62 rs1038769207 0.1723 -0.22 0.235 N 0.339 0.302 0.427139414373 gnomAD-4.0.0 3.84376E-06 None None None None N None 0 3.38937E-05 None 0 0 None 0 0 0 0 2.84463E-05
R/G 33352 Fn3-130 63 rs1221389929 0.9037 -0.669 1.0 N 0.709 0.389 0.492681238296 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.61E-05 None 0 None 0 0 0
R/G 33352 Fn3-130 63 rs1221389929 0.9037 -0.669 1.0 N 0.709 0.389 0.492681238296 gnomAD-4.0.0 1.59287E-06 None None None None N None 0 0 None 0 2.77778E-05 None 0 0 0 0 0
T/I 33748 Fn3-132 60 rs750315507 0.4984 0.114 1.0 N 0.846 0.484 0.545869088564 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
T/I 33748 Fn3-132 60 rs750315507 0.4984 0.114 1.0 N 0.846 0.484 0.545869088564 gnomAD-4.0.0 1.36836E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79884E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.