Structural position:

  • Domain Type: Fn3
  • Aligned Position: 94
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
T/A 15922 Fn3-3 64 rs2057504712 0.1096 None 0.201 N 0.263 0.169 0.225902525712 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
T/I 15922 Fn3-3 64 rs2057504360 0.2368 None 0.379 N 0.369 0.385 0.38225645794 gnomAD-4.0.0 2.1552E-06 None None None None N None 0 0 None 0 8.23497E-05 None 0 0 0 0 0
P/A 16117 Fn3-4 63 None 0.0873 None 0.002 N 0.189 0.118 0.146414634003 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
P/L 16117 Fn3-4 63 None 0.1269 None 0.379 N 0.495 0.258 0.52586976336 gnomAD-4.0.0 1.59514E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4346E-05 0
T/R 16217 Fn3-5 63 None 0.1163 None 1.0 N 0.818 0.362 0.604264793904 gnomAD-4.0.0 1.63013E-06 None None None None N None 0 0 None 0 0 None 0 0 2.92401E-06 0 0
T/I 16413 Fn3-6 63 None 0.2141 None 0.454 D 0.461 0.302 0.286848849266 gnomAD-4.0.0 1.59389E-06 None None None None N None 0 0 None 0 0 None 1.88437E-05 0 0 0 0
T/N 16413 Fn3-6 63 None 0.1199 None 0.966 D 0.458 0.292 0.297718772494 gnomAD-4.0.0 1.59389E-06 None None None None N None 0 0 None 0 0 None 0 2.41546E-04 0 0 0
P/A 16613 Fn3-8 63 rs1468557688 0.0803 -0.688 0.005 N 0.317 0.111 0.117506650769 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
P/A 16613 Fn3-8 63 rs1468557688 0.0803 -0.688 0.005 N 0.317 0.111 0.117506650769 gnomAD-3.1.2 1.32E-05 None None None None N None 0 6.56E-05 0 0 0 None 0 0 1.47E-05 0 0
P/A 16613 Fn3-8 63 rs1468557688 0.0803 -0.688 0.005 N 0.317 0.111 0.117506650769 gnomAD-4.0.0 5.58175E-06 None None None None N None 0 1.66973E-05 None 0 0 None 0 0 6.78405E-06 0 0
P/S 16613 Fn3-8 63 None 0.101 None 0.012 N 0.361 0.109 0.0954503805726 gnomAD-4.0.0 6.8468E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15974E-05 0
T/I 16713 Fn3-9 63 rs2056496324 0.3035 None 0.782 D 0.712 0.303 0.56380075071 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
T/I 16713 Fn3-9 63 rs2056496324 0.3035 None 0.782 D 0.712 0.303 0.56380075071 gnomAD-4.0.0 6.58233E-06 None None None None N None 0 6.55824E-05 None 0 0 None 0 0 0 0 0
T/I 16814 Fn3-10 64 None 0.5166 None 1.0 D 0.798 0.473 0.55999961142 gnomAD-4.0.0 6.84561E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9981E-07 0 0
E/K 16915 Fn3-11 64 None 0.3661 None 0.939 N 0.481 0.33 0.263140351381 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/E 17109 Fn3-12 63 None 0.3891 None 0.999 N 0.594 0.421 0.307016933798 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/G 17532 Fn3-15 63 rs1401966542 0.1148 None 0.117 N 0.483 0.217 0.218112801441 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
D/G 17532 Fn3-15 63 rs1401966542 0.1148 None 0.117 N 0.483 0.217 0.218112801441 gnomAD-4.0.0 1.86094E-06 None None None None N None 2.67294E-05 0 None 0 0 None 0 0 8.4811E-07 0 0
D/H 17532 Fn3-15 63 None 0.164 None 0.484 N 0.581 0.254 0.273503213844 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 6.07533E-05 0
D/V 17532 Fn3-15 63 None 0.111 None 0.317 N 0.588 0.271 0.385906861911 gnomAD-4.0.0 6.84882E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99967E-07 0 0
T/I 17825 Fn3-17 62 rs2055078355 0.3198 None 0.454 N 0.346 0.21 0.463843524616 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/A 17925 Fn3-18 64 rs1488258025 0.18 -0.443 0.22 N 0.602 0.239 0.267299060538 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/A 17925 Fn3-18 64 rs1488258025 0.18 -0.443 0.22 N 0.602 0.239 0.267299060538 gnomAD-4.0.0 6.57903E-06 None None None None N None 2.41324E-05 0 None 0 0 None 0 0 0 0 0
W/C 18129 Fn3-19 65 None 0.938 None 0.999 N 0.659 0.315 0.444807159249 gnomAD-4.0.0 2.18193E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.92742E-05
W/G 18129 Fn3-19 65 rs773082246 0.7069 -1.279 0.946 N 0.587 0.417 0.473853734676 gnomAD-2.1.1 6.27E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.23E-05 0
W/G 18129 Fn3-19 65 rs773082246 0.7069 -1.279 0.946 N 0.587 0.417 0.473853734676 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
W/G 18129 Fn3-19 65 rs773082246 0.7069 -1.279 0.946 N 0.587 0.417 0.473853734676 gnomAD-4.0.0 3.27269E-06 None None None None N None 0 0 None 0 0 None 0 0 5.99772E-06 0 0
P/T 18234 Fn3-20 69 rs1060500416 0.1984 None 0.891 N 0.485 0.182 0.305410167561 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
P/T 18234 Fn3-20 69 rs1060500416 0.1984 None 0.891 N 0.485 0.182 0.305410167561 gnomAD-4.0.0 6.58371E-06 None None None None N None 2.41639E-05 0 None 0 0 None 0 0 0 0 0
P/L 18337 Fn3-21 66 rs764568599 0.1844 -0.215 1.0 N 0.856 0.456 0.61577956724 gnomAD-2.1.1 1.53053E-04 None None None None N None 0 9.58578E-04 None 0 0 None 0 None 0 0 8.31117E-04
P/L 18337 Fn3-21 66 rs764568599 0.1844 -0.215 1.0 N 0.856 0.456 0.61577956724 gnomAD-3.1.2 1.98E-05 None None None None N None 0 1.96954E-04 0 0 0 None 0 0 0 0 0
P/L 18337 Fn3-21 66 rs764568599 0.1844 -0.215 1.0 N 0.856 0.456 0.61577956724 gnomAD-4.0.0 6.67007E-05 None None None None N None 0 7.97556E-04 None 4.09433E-05 0 None 0 0 2.39623E-06 0 8.53874E-05
P/R 18337 Fn3-21 66 None 0.2295 None 1.0 N 0.825 0.5 0.446111551642 gnomAD-4.0.0 1.59324E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43345E-05 0
P/A 18541 Fn3-22 63 rs749140088 0.1385 None 0.984 N 0.597 0.31 0.349870743963 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/G 18647 Fn3-23 69 rs2053260795 0.218 None 1.0 N 0.775 0.474 0.382592752248 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
E/G 18647 Fn3-23 69 rs2053260795 0.218 None 1.0 N 0.775 0.474 0.382592752248 gnomAD-4.0.0 2.47995E-06 None None None None N None 0 1.66828E-05 None 0 0 None 0 0 2.54381E-06 0 0
P/A 18847 Fn3-24 64 None 0.1117 None 0.91 N 0.509 0.194 0.32306181527 gnomAD-4.0.0 1.41796E-06 None None None None N None 0 0 None 0 0 None 0 0 9.15245E-07 0 1.71892E-05
P/H 18847 Fn3-24 64 None 0.2282 None 0.998 N 0.668 0.323 0.473538153929 gnomAD-4.0.0 1.73601E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.71444E-05 0
P/S 18847 Fn3-24 64 rs763491342 0.1287 -1.449 0.925 N 0.51 0.223 0.29132392195 gnomAD-2.1.1 9.82E-06 None None None None N None 0 0 None 0 1.26936E-04 None 0 None 0 0 0
P/S 18847 Fn3-24 64 rs763491342 0.1287 -1.449 0.925 N 0.51 0.223 0.29132392195 gnomAD-4.0.0 1.41796E-06 None None None None N None 0 0 None 0 5.11823E-05 None 0 0 0 0 0
T/I 18951 Fn3-25 68 None 0.2987 None 0.997 N 0.799 0.453 0.432604763906 gnomAD-4.0.0 1.36877E-06 None None None None N None 2.99061E-05 0 None 0 0 None 0 0 8.99643E-07 0 0
T/N 18951 Fn3-25 68 rs2052524114 0.125 None 0.993 N 0.645 0.311 0.369309618794 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/N 18951 Fn3-25 68 rs2052524114 0.125 None 0.993 N 0.645 0.311 0.369309618794 gnomAD-4.0.0 1.85971E-06 None None None None N None 0 0 None 0 0 None 0 0 2.5434E-06 0 0
T/P 19051 Fn3-26 64 None 0.0612 None 0.001 N 0.207 0.233 0.148003135375 gnomAD-4.0.0 1.59234E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86E-06 0 0
Q/H 19246 Fn3-27 64 None 0.1867 None 0.999 N 0.699 0.284 0.274366138417 gnomAD-4.0.0 1.62833E-06 None None None None N None 0 0 None 0 2.8231E-05 None 0 0 0 0 0
Q/R 19246 Fn3-27 64 None 0.1215 None 0.997 N 0.588 0.41 0.247322355667 gnomAD-4.0.0 1.62689E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.48712E-05 0
S/P 19542 Fn3-29 64 rs145198325 0.0514 -0.208 None N 0.215 0.108 None gnomAD-2.1.1 2.42E-05 None None None None N None 1.93773E-04 8.72E-05 None 0 0 None 0 None 0 0 0
S/P 19542 Fn3-29 64 rs145198325 0.0514 -0.208 None N 0.215 0.108 None gnomAD-3.1.2 1.05213E-04 None None None None N None 3.61934E-04 0 1.09649E-03 0 0 None 0 0 0 0 0
S/P 19542 Fn3-29 64 rs145198325 0.0514 -0.208 None N 0.215 0.108 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
S/P 19542 Fn3-29 64 rs145198325 0.0514 -0.208 None N 0.215 0.108 None gnomAD-4.0.0 1.98349E-05 None None None None N None 3.59904E-04 6.67223E-05 None 0 0 None 0 0 0 0 0
S/Y 19542 Fn3-29 64 None 0.2097 None 0.295 D 0.519 0.312 0.666034180468 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 20038 Fn3-33 62 None 0.1075 None 0.999 N 0.539 0.441 0.359963025489 gnomAD-4.0.0 1.59194E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85953E-06 0 0
T/I 20038 Fn3-33 62 None 0.2566 None 1.0 N 0.796 0.485 0.494769474416 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/S 20234 Fn3-34 64 None 0.1313 None 0.689 N 0.266 0.253 0.219573609325 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/S 20435 Fn3-36 65 None 0.1583 None 0.978 N 0.599 0.327 0.327952845175 gnomAD-4.0.0 1.5969E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86507E-06 0 0
A/D 20630 Fn3-37 62 None 0.9268 None 1.0 N 0.772 0.47 0.501685917333 gnomAD-4.0.0 6.84328E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9959E-07 0 0
A/G 20630 Fn3-37 62 None 0.292 None 1.0 N 0.601 0.388 0.292787519742 gnomAD-4.0.0 6.84328E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9959E-07 0 0
A/T 20630 Fn3-37 62 None 0.1621 None 1.0 N 0.706 0.376 0.197625483188 gnomAD-4.0.0 1.59194E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85951E-06 0 0
A/V 20630 Fn3-37 62 rs2154184048 0.2382 None 1.0 N 0.629 0.424 0.392547445146 gnomAD-4.0.0 6.84328E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9959E-07 0 0
D/G 20731 Fn3-38 64 None 0.5455 None 0.998 N 0.747 0.434 0.359963025489 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
T/R 20926 Fn3-39 63 None 0.3209 None 0.988 N 0.511 0.409 0.490352026379 gnomAD-4.0.0 1.36932E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31965E-05 0
Q/H 21026 Fn3-40 64 rs1383048418 0.1855 -0.461 0.954 N 0.331 0.186 0.21737058555 gnomAD-2.1.1 4.09E-06 None None None None N None 0 0 None 0 5.62E-05 None 0 None 0 0 0
Q/H 21026 Fn3-40 64 rs1383048418 0.1855 -0.461 0.954 N 0.331 0.186 0.21737058555 gnomAD-4.0.0 1.60215E-06 None None None None N None 0 0 None 0 2.77701E-05 None 0 0 0 0 0
Q/K 21026 Fn3-40 64 rs2049579414 0.0953 None 0.285 N 0.213 0.173 0.107399877778 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.78011E-04
Q/K 21026 Fn3-40 64 rs2049579414 0.0953 None 0.285 N 0.213 0.173 0.107399877778 gnomAD-4.0.0 6.57817E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 4.78011E-04
Q/R 21026 Fn3-40 64 rs2049578879 0.1133 None 0.662 N 0.198 0.16 0.107399877778 gnomAD-4.0.0 1.60147E-06 None None None None N None 5.73921E-05 0 None 0 0 None 0 0 0 0 0
T/A 21133 Fn3-41 70 rs766276741 0.0893 -0.503 0.704 N 0.352 0.174 0.227934060464 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
T/A 21133 Fn3-41 70 rs766276741 0.0893 -0.503 0.704 N 0.352 0.174 0.227934060464 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/A 21133 Fn3-41 70 rs766276741 0.0893 -0.503 0.704 N 0.352 0.174 0.227934060464 gnomAD-4.0.0 3.10019E-06 None None None None N None 0 0 None 0 0 None 0 0 4.23953E-06 0 0
T/I 21133 Fn3-41 70 rs1576043145 0.2 None 0.988 N 0.547 0.281 None gnomAD-4.0.0 1.36918E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99766E-07 0 1.65761E-05
T/N 21328 Fn3-42 63 rs370506995 0.0865 None 0.188 N 0.49 0.139 0.321672782286 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
T/N 21328 Fn3-42 63 rs370506995 0.0865 None 0.188 N 0.49 0.139 0.321672782286 gnomAD-4.0.0 2.56422E-06 None None None None N None 0 1.69635E-05 None 0 0 None 0 0 2.39485E-06 0 0
T/I 21429 Fn3-43 64 rs1276697618 0.1702 -0.238 0.012 N 0.401 0.102 0.208000267992 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14837E-04 0 None 0 0 None 0 None 0 0 0
T/I 21429 Fn3-43 64 rs1276697618 0.1702 -0.238 0.012 N 0.401 0.102 0.208000267992 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 21429 Fn3-43 64 rs1276697618 0.1702 -0.238 0.012 N 0.401 0.102 0.208000267992 gnomAD-4.0.0 2.56412E-06 None None None None N None 3.38547E-05 0 None 0 0 None 0 0 0 0 0
E/D 22018 Fn3-47 63 rs727503579 0.1846 -0.374 0.014 N 0.29 0.031 0.245660935333 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
E/D 22018 Fn3-47 63 rs727503579 0.1846 -0.374 0.014 N 0.29 0.031 0.245660935333 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/D 22018 Fn3-47 63 rs727503579 0.1846 -0.374 0.014 N 0.29 0.031 0.245660935333 gnomAD-4.0.0 2.48027E-05 None None None None N None 0 0 None 0 0 None 0 0 3.30692E-05 0 1.60251E-05
E/G 22018 Fn3-47 63 None 0.3206 None 0.822 N 0.672 0.322 0.342631996419 gnomAD-4.0.0 1.20038E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31257E-06 0 0
T/A 22118 Fn3-48 64 None 0.0743 None 0.001 N 0.139 0.058 0.117506650769 gnomAD-4.0.0 1.59217E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86036E-06 0 0
T/I 22118 Fn3-48 64 rs751985481 0.2071 0.053 0.213 N 0.442 0.142 None gnomAD-2.1.1 1.21E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 1.78E-05 0
T/I 22220 Fn3-49 65 None 0.2267 None 1.0 N 0.807 0.431 0.495706241231 gnomAD-4.0.0 1.36926E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31949E-05 0
A/G 22416 Fn3-50 63 None 0.0995 None 0.001 N 0.243 0.139 0.107399877778 gnomAD-4.0.0 1.59219E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43303E-05 0
A/P 22416 Fn3-50 63 rs4145333 0.083 -0.629 None N 0.188 0.101 None gnomAD-2.1.1 9.98514E-01 None None None None N None 9.86275E-01 9.9884E-01 None 1E+00 1E+00 None 1E+00 None 1E+00 9.99695E-01 9.99438E-01
A/P 22416 Fn3-50 63 rs4145333 0.083 -0.629 None N 0.188 0.101 None gnomAD-3.1.2 9.96021E-01 None None None None N None 9.86485E-01 9.98754E-01 1E+00 1E+00 9.99805E-01 None 1E+00 9.90506E-01 9.99735E-01 1E+00 9.98088E-01
A/P 22416 Fn3-50 63 rs4145333 0.083 -0.629 None N 0.188 0.101 None 1000 genomes 9.94609E-01 None None None None N None 9.811E-01 9.971E-01 None None 1E+00 1E+00 None None None 1E+00 None
A/P 22416 Fn3-50 63 rs4145333 0.083 -0.629 None N 0.188 0.101 None gnomAD-4.0.0 9.99095E-01 None None None None N None 9.85665E-01 9.9885E-01 None 1E+00 9.99978E-01 None 1E+00 9.97851E-01 9.99807E-01 9.99978E-01 9.98847E-01
K/R 22511 Fn3-51 61 rs368046394 0.0755 0.308 0.001 N 0.154 0.134 None gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
K/R 22511 Fn3-51 61 rs368046394 0.0755 0.308 0.001 N 0.154 0.134 None gnomAD-4.0.0 2.05314E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69897E-06 0 0
T/I 22706 Fn3-52 64 rs765762900 0.3373 0.119 0.004 N 0.315 0.116 0.242825505644 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/I 22706 Fn3-52 64 rs765762900 0.3373 0.119 0.004 N 0.315 0.116 0.242825505644 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 22706 Fn3-52 64 rs765762900 0.3373 0.119 0.004 N 0.315 0.116 0.242825505644 gnomAD-4.0.0 2.564E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78962E-06 0 0
T/A 22806 Fn3-53 64 None 0.0799 None 0.011 N 0.175 0.196 0.185906805712 gnomAD-4.0.0 1.36882E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79934E-06 0 0
T/I 22806 Fn3-53 64 rs727503573 0.1693 -0.148 0.968 D 0.64 0.336 0.385906861911 gnomAD-2.1.1 4.03E-05 None None None None N None 0 0 None 0 0 None 3.26904E-04 None 0 0 0
T/I 22806 Fn3-53 64 rs727503573 0.1693 -0.148 0.968 D 0.64 0.336 0.385906861911 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 0 4.14594E-04 0
T/I 22806 Fn3-53 64 rs727503573 0.1693 -0.148 0.968 D 0.64 0.336 0.385906861911 gnomAD-4.0.0 3.47157E-05 None None None None N None 0 0 None 0 0 None 0 0 1.0174E-05 4.83198E-04 0
T/I 22904 Fn3-54 64 rs779476151 0.2665 -0.12 0.997 N 0.721 0.446 None gnomAD-2.1.1 8.07E-06 None None None None I None 1.29266E-04 0 None 0 0 None 0 None 0 0 0
T/I 22904 Fn3-54 64 rs779476151 0.2665 -0.12 0.997 N 0.721 0.446 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 22904 Fn3-54 64 rs779476151 0.2665 -0.12 0.997 N 0.721 0.446 None gnomAD-4.0.0 3.8454E-06 None None None None I None 5.07614E-05 0 None 0 0 None 0 0 0 0 0
T/N 22904 Fn3-54 64 rs779476151 0.1133 -0.205 0.1 N 0.29 0.322 0.269558022972 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
T/N 22904 Fn3-54 64 rs779476151 0.1133 -0.205 0.1 N 0.29 0.322 0.269558022972 gnomAD-4.0.0 3.18441E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71932E-06 0 0
T/S 23102 Fn3-55 63 rs1372466257 0.0951 -0.61 None N 0.109 0.098 0.12205267543 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 1.1147E-04 None 0 None 0 0 0
T/S 23102 Fn3-55 63 rs1372466257 0.0951 -0.61 None N 0.109 0.098 0.12205267543 gnomAD-4.0.0 1.59186E-06 None None None None N None 0 0 None 0 2.77408E-05 None 0 0 0 0 0
T/A 23202 Fn3-56 64 rs2046496039 0.0855 None 0.001 N 0.127 0.082 0.130388298395 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/A 23202 Fn3-56 64 rs2046496039 0.0855 None 0.001 N 0.127 0.082 0.130388298395 gnomAD-4.0.0 2.03007E-06 None None None None N None 1.74709E-05 0 None 0 0 None 0 0 1.20499E-06 0 0
T/I 23202 Fn3-56 64 None 0.1882 None 0.655 N 0.547 0.27 0.40528724903 gnomAD-4.0.0 1.59161E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43291E-05 0
T/I 23497 Fn3-58 63 None 0.1144 None 0.966 N 0.575 0.351 0.409665357357 gnomAD-4.0.0 1.5917E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85915E-06 0 0
R/G 23593 Fn3-59 62 rs930124570 0.1122 -0.479 0.024 N 0.394 0.135 0.360163838653 gnomAD-2.1.1 7.15E-06 None None None None N None 8.26E-05 0 None 0 0 None 0 None 0 0 0
R/G 23593 Fn3-59 62 rs930124570 0.1122 -0.479 0.024 N 0.394 0.135 0.360163838653 gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
R/G 23593 Fn3-59 62 rs930124570 0.1122 -0.479 0.024 N 0.394 0.135 0.360163838653 gnomAD-4.0.0 3.84434E-06 None None None None N None 5.07288E-05 0 None 0 0 None 0 0 0 0 0
R/K 23593 Fn3-59 62 None 0.0555 None None N 0.099 0.119 0.110078149338 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
T/A 23789 Fn3-60 64 None 0.0902 None 0.002 N 0.127 0.103 0.148003135375 gnomAD-4.0.0 6.84911E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65876E-05
S/T 23987 Fn3-62 64 rs764752985 0.0742 -0.298 0.17 N 0.325 0.129 0.110078149338 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
S/F 24285 Fn3-64 64 None 0.1936 None 0.983 N 0.771 0.476 0.715032251236 gnomAD-4.0.0 6.9043E-07 None None None None N None 0 0 None 0 0 None 0 0 9.04819E-07 0 0
T/I 24387 Fn3-65 65 None 0.1357 None 0.997 N 0.743 0.415 0.491112125781 gnomAD-4.0.0 1.59265E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86004E-06 0 0
D/A 24581 Fn3-66 63 None 0.1913 None 0.035 N 0.486 0.138 0.266385636622 gnomAD-4.0.0 6.84517E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99845E-07 0 0
D/E 24581 Fn3-66 63 rs727504603 0.0926 None None N 0.132 0.076 0.115124310173 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/E 24581 Fn3-66 63 rs727504603 0.0926 None None N 0.132 0.076 0.115124310173 gnomAD-4.0.0 2.46432E-05 None None None None N None 0 0 None 0 0 None 1.87322E-05 0 3.14953E-05 0 0
T/A 24677 Fn3-67 62 rs1708422337 0.08 None 0.019 N 0.289 0.157 0.18274738541 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/A 24677 Fn3-67 62 rs1708422337 0.08 None 0.019 N 0.289 0.157 0.18274738541 gnomAD-4.0.0 6.57635E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47089E-05 0 0
T/S 24677 Fn3-67 62 rs749016497 0.0878 -0.056 0.419 N 0.441 0.115 0.173771789658 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/S 24677 Fn3-67 62 rs749016497 0.0878 -0.056 0.419 N 0.441 0.115 0.173771789658 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07383E-04 0
T/S 24677 Fn3-67 62 rs749016497 0.0878 -0.056 0.419 N 0.441 0.115 0.173771789658 gnomAD-4.0.0 1.23976E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.19669E-05 0
C/G 24871 Fn3-68 64 rs1277175098 0.0871 -1.367 0.028 N 0.354 0.13 0.276898752692 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
C/G 24871 Fn3-68 64 rs1277175098 0.0871 -1.367 0.028 N 0.354 0.13 0.276898752692 gnomAD-4.0.0 1.59239E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85958E-06 0 0
T/I 24971 Fn3-69 64 None 0.1148 None 0.669 N 0.466 0.263 0.347879110917 gnomAD-4.0.0 2.0529E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69869E-06 0 0
T/A 25267 Fn3-71 64 rs1707717762 0.1434 None 0.581 N 0.417 0.195 0.27132560031 gnomAD-4.0.0 1.5924E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85946E-06 0 0
T/S 25267 Fn3-71 64 None 0.1424 None 0.738 N 0.415 0.233 0.262175524916 gnomAD-4.0.0 1.5924E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85946E-06 0 0
T/I 25367 Fn3-72 64 rs756655305 0.3515 -0.082 0.999 N 0.791 0.456 None gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
T/I 25367 Fn3-72 64 rs756655305 0.3515 -0.082 0.999 N 0.791 0.456 None gnomAD-4.0.0 1.11467E-05 None None None None N None 0 0 None 0 0 None 0 0 2.00191E-05 0 0
T/N 25367 Fn3-72 64 None 0.1693 None 0.999 N 0.633 0.374 0.46614307118 gnomAD-4.0.0 1.59239E-06 None None None None N None 0 0 None 0 2.77901E-05 None 0 0 0 0 0
D/N 25663 Fn3-74 63 rs143186270 0.0888 -0.296 0.317 N 0.537 0.206 None gnomAD-2.1.1 1.46594E-04 None None None None N None 9.92392E-04 8.49E-05 None 0 0 None 0 None 0 1.0179E-04 1.40766E-04
D/N 25663 Fn3-74 63 rs143186270 0.0888 -0.296 0.317 N 0.537 0.206 None gnomAD-3.1.2 3.41934E-04 None None None None N None 9.89526E-04 0 0 0 0 None 0 0 1.4705E-04 0 4.78927E-04
D/N 25663 Fn3-74 63 rs143186270 0.0888 -0.296 0.317 N 0.537 0.206 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
D/N 25663 Fn3-74 63 rs143186270 0.0888 -0.296 0.317 N 0.537 0.206 None gnomAD-4.0.0 1.35122E-04 None None None None N None 9.86719E-04 3.335E-05 None 0 0 None 0 0 1.16147E-04 0 8.00615E-05
D/Y 25663 Fn3-74 63 rs143186270 0.2371 -0.217 0.973 N 0.779 0.425 0.578877614382 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 1.78E-05 0
D/Y 25663 Fn3-74 63 rs143186270 0.2371 -0.217 0.973 N 0.779 0.425 0.578877614382 gnomAD-4.0.0 7.52829E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99648E-06 1.16031E-05 0
T/N 25759 Fn3-75 62 rs1399797498 0.0994 -0.05 0.828 N 0.41 0.199 0.288352970974 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66003E-04
T/N 25759 Fn3-75 62 rs1399797498 0.0994 -0.05 0.828 N 0.41 0.199 0.288352970974 gnomAD-4.0.0 1.59287E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.0259E-05
Q/H 26053 Fn3-77 64 rs1475071129 0.1155 -0.455 0.032 N 0.457 0.048 0.146414634003 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
Q/H 26053 Fn3-77 64 rs1475071129 0.1155 -0.455 0.032 N 0.457 0.048 0.146414634003 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/H 26053 Fn3-77 64 rs1475071129 0.1155 -0.455 0.032 N 0.457 0.048 0.146414634003 gnomAD-4.0.0 6.57531E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47072E-05 0 0
Q/R 26053 Fn3-77 64 None 0.1167 None 0.003 N 0.247 0.065 0.0716867268079 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 26349 Fn3-79 64 None 0.1719 None 0.928 N 0.43 0.36 0.319970858106 gnomAD-4.0.0 3.601E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62502E-06 0 3.66354E-05
E/Q 26745 Fn3-82 63 None 0.1649 None 0.684 N 0.423 0.101 0.225215365344 gnomAD-4.0.0 6.36649E-06 None None None None N None 0 0 None 0 0 None 0 0 1.14365E-05 0 0
T/S 27035 Fn3-84 64 rs1705169163 0.103 None None N 0.179 0.058 0.137902524267 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
T/S 27035 Fn3-84 64 rs1705169163 0.103 None None N 0.179 0.058 0.137902524267 gnomAD-4.0.0 6.57575E-06 None None None None N None 0 6.55824E-05 None 0 0 None 0 0 0 0 0
T/A 27135 Fn3-85 64 None 0.0655 None 0.01 N 0.123 0.134 0.19670166235 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 27135 Fn3-85 64 rs1341053219 0.1013 None 0.642 N 0.531 0.23 0.490771696789 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 27135 Fn3-85 64 rs1341053219 0.1013 None 0.642 N 0.531 0.23 0.490771696789 gnomAD-4.0.0 6.57402E-06 None None None None N None 2.41313E-05 0 None 0 0 None 0 0 0 0 0
S/N 27233 Fn3-86 64 None 0.1899 None 0.117 N 0.418 0.101 0.18274738541 gnomAD-4.0.0 1.59359E-06 None None None None N None 0 0 None 0 0 None 0 2.41196E-04 0 0 0
T/N 27432 Fn3-87 64 None 0.2032 None 0.988 N 0.6 0.364 0.449860987313 gnomAD-4.0.0 1.59136E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85845E-06 0 0
T/I 27532 Fn3-88 64 rs763850217 0.3227 -0.093 0.999 N 0.783 0.393 0.494634796122 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.66E-05 0
T/I 27532 Fn3-88 64 rs763850217 0.3227 -0.093 0.999 N 0.783 0.393 0.494634796122 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 27532 Fn3-88 64 rs763850217 0.3227 -0.093 0.999 N 0.783 0.393 0.494634796122 gnomAD-4.0.0 5.5774E-06 None None None None N None 0 0 None 0 0 None 0 0 5.93342E-06 0 3.20215E-05
T/S 27532 Fn3-88 64 rs763850217 0.1221 -0.367 0.905 N 0.337 0.169 0.273938319068 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
T/S 27532 Fn3-88 64 rs763850217 0.1221 -0.367 0.905 N 0.337 0.169 0.273938319068 gnomAD-4.0.0 1.36843E-06 None None None None N None 0 0 None 0 2.52029E-05 None 0 0 8.99483E-07 0 0
T/I 27634 Fn3-89 65 rs780363524 0.1683 -0.129 0.996 N 0.559 0.372 None gnomAD-2.1.1 1.16795E-04 None None None None N None 0 0 None 0 0 None 0 None 6.49712E-04 1.24819E-04 1.65837E-04
T/I 27634 Fn3-89 65 rs780363524 0.1683 -0.129 0.996 N 0.559 0.372 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 27634 Fn3-89 65 rs780363524 0.1683 -0.129 0.996 N 0.559 0.372 None gnomAD-4.0.0 6.02226E-05 None None None None N None 0 0 None 0 0 None 2.82353E-04 0 5.98358E-05 0 1.13779E-04
E/D 27828 Fn3-90 63 rs1234125693 0.0707 -0.477 0.005 N 0.124 0.1 0.203808441222 gnomAD-2.1.1 4.25E-06 None None None None N None 0 0 None 0 0 None 3.75E-05 None 0 0 0
E/D 27828 Fn3-90 63 rs1234125693 0.0707 -0.477 0.005 N 0.124 0.1 0.203808441222 gnomAD-4.0.0 1.625E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.5063E-05 0
S/C 27924 Fn3-91 62 rs753769882 0.0999 -0.376 0.873 N 0.416 0.273 0.319402600006 gnomAD-2.1.1 4.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.98E-06 0
S/F 27924 Fn3-91 62 None 0.1615 None 0.001 N 0.315 0.171 0.344251166708 gnomAD-4.0.0 1.37121E-06 None None None None N None 3.00354E-05 0 None 0 0 None 0 0 9.00361E-07 0 0
S/P 27924 Fn3-91 62 None 0.1219 None 0.391 N 0.449 0.164 0.21279746466 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 28117 Fn3-92 63 None 0.126 None None N 0.089 0.079 0.252681307341 gnomAD-4.0.0 1.5917E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85861E-06 0 0
V/F 28117 Fn3-92 63 None 0.1535 None 0.427 N 0.554 0.085 0.377976839388 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/F 28217 Fn3-93 64 rs888839405 0.1602 None 0.295 N 0.59 0.25 0.431035450679 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
S/F 28217 Fn3-93 64 rs888839405 0.1602 None 0.295 N 0.59 0.25 0.431035450679 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
S/F 28217 Fn3-93 64 rs888839405 0.1602 None 0.295 N 0.59 0.25 0.431035450679 gnomAD-4.0.0 1.3147E-05 None None None None N None 4.82672E-05 0 None 0 0 None 0 0 0 0 0
S/P 28217 Fn3-93 64 rs1271151421 0.1309 -0.383 0.106 N 0.541 0.167 0.15556083564 gnomAD-2.1.1 2.86E-05 None None None None N None 3.30633E-04 0 None 0 0 None 0 None 0 0 0
S/P 28217 Fn3-93 64 rs1271151421 0.1309 -0.383 0.106 N 0.541 0.167 0.15556083564 gnomAD-3.1.2 3.29E-05 None None None None N None 1.20592E-04 0 0 0 0 None 0 0 0 0 0
S/P 28217 Fn3-93 64 rs1271151421 0.1309 -0.383 0.106 N 0.541 0.167 0.15556083564 gnomAD-4.0.0 8.67593E-06 None None None None N None 1.73495E-04 0 None 0 0 None 0 0 0 0 1.60108E-05
T/S 28315 Fn3-94 64 rs1369979989 0.1087 -0.646 0.977 N 0.399 0.255 0.211220785272 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
T/S 28315 Fn3-94 64 rs1369979989 0.1087 -0.646 0.977 N 0.399 0.255 0.211220785272 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
T/S 28315 Fn3-94 64 rs1369979989 0.1087 -0.646 0.977 N 0.399 0.255 0.211220785272 gnomAD-4.0.0 7.43744E-06 None None None None N None 1.60197E-04 0 None 0 0 None 0 0 0 0 0
T/I 28513 Fn3-95 64 None 0.2688 None 0.994 N 0.769 0.41 0.529813890454 gnomAD-4.0.0 1.36876E-06 None None None None N None 0 0 None 0 2.5264E-05 None 0 0 8.99502E-07 0 0
T/P 28513 Fn3-95 64 None 0.1186 None 0.067 N 0.342 0.314 0.29385284311 gnomAD-4.0.0 3.60098E-06 None None None None N None 0 0 None 0 0 None 0 0 3.93752E-06 0 0
T/A 28613 Fn3-96 64 rs1341127613 0.0664 -0.519 0.005 N 0.229 0.118 0.139678290688 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.65673E-04
T/A 28613 Fn3-96 64 rs1341127613 0.0664 -0.519 0.005 N 0.229 0.118 0.139678290688 gnomAD-4.0.0 3.42098E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69838E-06 0 3.31312E-05
T/I 28613 Fn3-96 64 rs368615862 0.1351 -0.173 None N 0.233 0.22 None gnomAD-2.1.1 3.57E-05 None None None None N None 0 0 None 0 0 None 0 None 0 7.8E-05 0
T/I 28613 Fn3-96 64 rs368615862 0.1351 -0.173 None N 0.233 0.22 None gnomAD-3.1.2 3.95E-05 None None None None N None 0 0 0 0 0 None 0 0 8.82E-05 0 0
T/I 28613 Fn3-96 64 rs368615862 0.1351 -0.173 None N 0.233 0.22 None gnomAD-4.0.0 5.89333E-05 None None None None N None 0 0 None 0 0 None 0 0 1.10077E-04 0 0
T/S 28613 Fn3-96 64 rs1341127613 0.0812 -0.246 None N 0.163 0.087 0.115124310173 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
T/S 28613 Fn3-96 64 rs1341127613 0.0812 -0.246 None N 0.163 0.087 0.115124310173 gnomAD-4.0.0 1.36839E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99459E-07 0 1.65656E-05
S/G 28713 Fn3-97 63 rs1703047213 0.0724 None None N 0.091 0.085 0.0846915920261 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/I 28713 Fn3-97 63 rs552631098 0.1019 -0.023 None N 0.287 0.086 None gnomAD-2.1.1 8.07E-06 None None None None N None 1.29282E-04 0 None 0 0 None 0 None 0 0 0
S/I 28713 Fn3-97 63 rs552631098 0.1019 -0.023 None N 0.287 0.086 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/I 28713 Fn3-97 63 rs552631098 0.1019 -0.023 None N 0.287 0.086 None gnomAD-4.0.0 2.56239E-06 None None None None N None 3.38329E-05 0 None 0 0 None 0 0 0 0 0
S/N 28713 Fn3-97 63 rs552631098 0.0893 -0.016 None N 0.126 0.071 0.0846915920261 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.9305E-04 None 0 0 0 0 0
S/N 28713 Fn3-97 63 rs552631098 0.0893 -0.016 None N 0.126 0.071 0.0846915920261 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
S/N 28713 Fn3-97 63 rs552631098 0.0893 -0.016 None N 0.126 0.071 0.0846915920261 gnomAD-4.0.0 2.56201E-06 None None None None N None 0 0 None 0 2.42907E-05 None 0 0 0 1.34005E-05 0
T/I 28907 Fn3-98 63 None 0.1193 None 0.031 N 0.311 0.222 0.314716216878 gnomAD-4.0.0 5.47407E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19638E-06 0 0
S/C 29003 Fn3-99 62 None 0.0785 None 0.993 N 0.559 0.391 0.368743488249 gnomAD-4.0.0 1.59128E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85796E-06 0 0
S/F 29003 Fn3-99 62 rs754378461 0.1185 -0.989 0.927 N 0.591 0.321 0.483596354421 gnomAD-2.1.1 8.05E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.9E-06 0
S/F 29003 Fn3-99 62 rs754378461 0.1185 -0.989 0.927 N 0.591 0.321 0.483596354421 gnomAD-4.0.0 4.77383E-06 None None None None N None 0 2.28624E-05 None 0 0 None 0 0 5.71592E-06 0 0
M/I 29200 Fn3-100 64 rs750362675 0.4273 -0.269 0.993 N 0.418 0.339 0.558342666981 gnomAD-2.1.1 2.36976E-04 None None None None N None 0 1.47817E-03 None 0 0 None 0 None 0 8.87E-06 1.15932E-03
M/I 29200 Fn3-100 64 rs750362675 0.4273 -0.269 0.993 N 0.418 0.339 0.558342666981 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.54E-05 0 0 0 None 0 0 0 0 0
M/I 29200 Fn3-100 64 rs750362675 0.4273 -0.269 0.993 N 0.418 0.339 0.558342666981 gnomAD-4.0.0 4.08963E-05 None None None None N None 0 9.83301E-04 None 0 0 None 0 0 1.69513E-06 0 8.00487E-05
M/K 29200 Fn3-100 64 None 0.2851 None 0.979 N 0.46 0.36 0.569949186141 gnomAD-4.0.0 6.84168E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65651E-05
M/T 29200 Fn3-100 64 None 0.1579 None 0.979 N 0.444 0.351 0.554315986709 gnomAD-4.0.0 2.73667E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79886E-06 2.31884E-05 0
M/V 29200 Fn3-100 64 rs1553554462 0.1251 None 0.951 N 0.444 0.259 0.520002024791 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
M/V 29200 Fn3-100 64 rs1553554462 0.1251 None 0.951 N 0.444 0.259 0.520002024791 gnomAD-4.0.0 6.56823E-06 None None None None N None 2.4108E-05 0 None 0 0 None 0 0 0 0 0
T/K 29300 Fn3-101 64 rs1428308872 0.321 -0.373 0.477 N 0.637 0.269 0.307016933798 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
T/K 29300 Fn3-101 64 rs1428308872 0.321 -0.373 0.477 N 0.637 0.269 0.307016933798 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/K 29300 Fn3-101 64 rs1428308872 0.321 -0.373 0.477 N 0.637 0.269 0.307016933798 gnomAD-4.0.0 1.0247E-05 None None None None N None 0 0 None 0 0 None 0 0 1.6748E-05 0 2.84349E-05
S/A 29398 Fn3-102 64 None 0.1003 None 0.349 N 0.319 0.083 0.151104730317 gnomAD-4.0.0 6.8421E-07 None None None None N None 0 0 None 0 0 None 0 1.7343E-04 0 0 0
T/A 29596 Fn3-103 64 None 0.0856 None 0.201 N 0.407 0.155 0.151104730317 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
T/I 29596 Fn3-103 64 rs786205371 0.2843 0.096 0.896 D 0.534 0.341 0.52186301387 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
T/I 29596 Fn3-103 64 rs786205371 0.2843 0.096 0.896 D 0.534 0.341 0.52186301387 gnomAD-4.0.0 4.78925E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29599E-06 0 0
T/S 29596 Fn3-103 64 rs786205371 0.0896 -0.466 0.016 N 0.177 0.078 0.154104182512 gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.34E-05 0
T/S 29596 Fn3-103 64 rs786205371 0.0896 -0.466 0.016 N 0.177 0.078 0.154104182512 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
T/S 29596 Fn3-103 64 rs786205371 0.0896 -0.466 0.016 N 0.177 0.078 0.154104182512 gnomAD-4.0.0 1.54928E-05 None None None None N None 1.3354E-05 0 None 0 0 None 0 0 1.77991E-05 0 4.80369E-05
T/P 29696 Fn3-104 64 rs1341013204 0.0973 -0.358 0.794 D 0.549 0.222 0.227260227426 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/P 29696 Fn3-104 64 rs1341013204 0.0973 -0.358 0.794 D 0.549 0.222 0.227260227426 gnomAD-4.0.0 1.59148E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02371E-05
S/A 29798 Fn3-105 65 rs886055232 0.0751 None 0.174 N 0.414 0.044 0.128392430309 gnomAD-4.0.0 2.05255E-06 None None None None N None 0 0 None 0 7.55858E-05 None 0 0 0 0 0
S/F 29798 Fn3-105 65 None 0.2798 None 0.957 N 0.761 0.367 0.593798965771 gnomAD-4.0.0 2.05258E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69838E-06 0 0
S/P 29798 Fn3-105 65 rs886055232 0.0703 None 0.003 N 0.317 0.198 0.149567049428 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/P 29798 Fn3-105 65 rs886055232 0.0703 None 0.003 N 0.317 0.198 0.149567049428 gnomAD-4.0.0 6.84185E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99449E-07 0 0
S/Y 29798 Fn3-105 65 rs1344691856 0.2131 -0.815 0.957 N 0.763 0.369 0.586756053714 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
S/Y 29798 Fn3-105 65 rs1344691856 0.2131 -0.815 0.957 N 0.763 0.369 0.586756053714 gnomAD-4.0.0 3.42096E-06 None None None None N None 0 0 None 0 0 None 0 0 4.4973E-06 0 0
I/R 29995 Fn3-106 63 rs754676727 0.084 None 0.014 N 0.466 0.05 0.197625483188 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
I/R 29995 Fn3-106 63 rs754676727 0.084 None 0.014 N 0.466 0.05 0.197625483188 gnomAD-4.0.0 1.97267E-05 None None None None N None 7.24218E-05 0 None 0 0 None 0 0 0 0 0
I/T 29995 Fn3-106 63 rs754676727 0.0456 -0.738 None N 0.131 0.09 None gnomAD-2.1.1 7.15E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.57E-05 0
I/T 29995 Fn3-106 63 rs754676727 0.0456 -0.738 None N 0.131 0.09 None gnomAD-3.1.2 3.29E-05 None None None None N None 9.66E-05 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 29995 Fn3-106 63 rs754676727 0.0456 -0.738 None N 0.131 0.09 None gnomAD-4.0.0 2.60286E-05 None None None None N None 8.01068E-05 0 None 0 0 None 3.12676E-05 0 2.7123E-05 1.09803E-05 1.60097E-05
S/G 30091 Fn3-107 62 None 0.0592 None None N 0.073 0.079 0.144782658237 gnomAD-4.0.0 3.1821E-06 None None None None N None 0 0 None 0 2.77377E-05 None 0 0 0 0 3.02334E-05
S/R 30091 Fn3-107 62 rs1460814289 0.2472 -0.144 0.033 N 0.477 0.08 0.20549828249 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
S/R 30091 Fn3-107 62 rs1460814289 0.2472 -0.144 0.033 N 0.477 0.08 0.20549828249 gnomAD-4.0.0 4.77324E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57349E-06 0 0
T/I 30387 Fn3-109 64 rs754591100 0.1078 -0.021 0.008 N 0.329 0.164 0.299770980665 gnomAD-2.1.1 8.05E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
T/I 30387 Fn3-109 64 rs754591100 0.1078 -0.021 0.008 N 0.329 0.164 0.299770980665 gnomAD-4.0.0 4.77377E-06 None None None None N None 0 4.57289E-05 None 0 0 None 0 0 0 0 3.02389E-05
T/I 30484 Fn3-110 63 rs1318850182 0.3014 None 0.983 N 0.757 0.444 0.425028116352 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 30484 Fn3-110 63 rs1318850182 0.3014 None 0.983 N 0.757 0.444 0.425028116352 gnomAD-4.0.0 6.57402E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
T/P 30783 Fn3-112 65 None 0.13 None 0.971 N 0.676 0.407 0.385578977469 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/N 30884 Fn3-113 64 rs1698294296 0.1168 None 0.891 N 0.448 0.282 0.314417295294 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/N 30884 Fn3-113 64 rs1698294296 0.1168 None 0.891 N 0.448 0.282 0.314417295294 gnomAD-4.0.0 1.23933E-06 None None None None N None 2.67023E-05 0 None 0 0 None 0 0 0 0 0
N/S 31078 Fn3-114 63 None 0.0472 None None N 0.103 0.125 0.0297737177859 gnomAD-4.0.0 3.18227E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71611E-06 0 0
E/G 31174 Fn3-115 62 None 0.1225 None 0.477 N 0.58 0.327 0.300784259202 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
T/I 31371 Fn3-116 64 rs767255232 0.3615 0.116 0.964 N 0.656 0.344 0.519889284407 gnomAD-4.0.0 5.47441E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19603E-06 0 0
T/I 31471 Fn3-117 64 rs759347301 0.1442 0.044 0.001 N 0.311 0.164 0.216624796971 gnomAD-2.1.1 1.2E-05 None None None None N None 0 5.79E-05 None 0 0 None 3.27E-05 None 0 0 0
T/I 31471 Fn3-117 64 rs759347301 0.1442 0.044 0.001 N 0.311 0.164 0.216624796971 gnomAD-4.0.0 1.02632E-05 None None None None N None 0 4.47227E-05 None 0 0 None 0 0 0 1.04338E-04 6.62691E-05
T/N 31770 Fn3-119 63 rs1250046145 0.1156 -0.944 0.997 D 0.605 0.326 0.40032279838 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/N 31770 Fn3-119 63 rs1250046145 0.1156 -0.944 0.997 D 0.605 0.326 0.40032279838 gnomAD-4.0.0 3.18231E-06 None None None None N None 0 2.28655E-05 None 0 0 None 0 0 0 0 3.02407E-05
P/L 31973 Fn3-121 65 rs377462274 0.1038 -0.333 0.012 N 0.276 0.091 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
P/L 31973 Fn3-121 65 rs377462274 0.1038 -0.333 0.012 N 0.276 0.091 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/L 31973 Fn3-121 65 rs377462274 0.1038 -0.333 0.012 N 0.276 0.091 None gnomAD-4.0.0 6.57402E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47003E-05 0 0
S/F 32167 Fn3-122 63 rs189733990 0.2286 -0.976 0.984 N 0.691 0.343 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
S/F 32167 Fn3-122 63 rs189733990 0.2286 -0.976 0.984 N 0.691 0.343 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/F 32167 Fn3-122 63 rs189733990 0.2286 -0.976 0.984 N 0.691 0.343 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
S/F 32167 Fn3-122 63 rs189733990 0.2286 -0.976 0.984 N 0.691 0.343 None gnomAD-4.0.0 2.56182E-06 None None None None N None 0 1.69428E-05 None 0 0 None 0 0 2.39307E-06 0 0
T/I 32663 Fn3-126 64 None 0.4864 None 1.0 N 0.807 0.447 0.620998120304 gnomAD-4.0.0 1.59118E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85832E-06 0 0
K/T 32858 Fn3-127 64 rs1322355821 0.4242 None 0.978 N 0.714 0.378 0.34854441366 gnomAD-4.0.0 3.18228E-06 None None None None N None 0 0 None 0 5.54539E-05 None 0 0 0 0 0
G/E 33061 Fn3-129 64 rs760665075 0.4093 0.094 1.0 N 0.747 0.414 0.454331543959 gnomAD-4.0.0 2.05264E-06 None None None None N None 0 6.70781E-05 None 0 0 None 0 0 0 0 0
G/R 33061 Fn3-129 64 rs2154139241 0.4104 None 1.0 N 0.725 0.455 0.616319364264 gnomAD-4.0.0 1.59127E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
G/V 33061 Fn3-129 64 rs760665075 0.2303 None 1.0 N 0.765 0.407 0.675944014053 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/V 33061 Fn3-129 64 rs760665075 0.2303 None 1.0 N 0.765 0.407 0.675944014053 gnomAD-4.0.0 1.23939E-06 None None None None N None 0 0 None 0 0 None 0 0 8.4762E-07 0 1.60108E-05
V/A 33354 Fn3-130 65 rs759484221 0.2242 -0.831 0.061 N 0.158 0.122 0.461144880706 gnomAD-2.1.1 8.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
V/A 33354 Fn3-130 65 rs759484221 0.2242 -0.831 0.061 N 0.158 0.122 0.461144880706 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 33354 Fn3-130 65 rs759484221 0.2242 -0.831 0.061 N 0.158 0.122 0.461144880706 gnomAD-4.0.0 8.67887E-06 None None None None N None 0 0 None 0 0 None 0 0 1.18689E-05 0 0
V/M 33354 Fn3-130 65 rs879221791 0.2371 -0.37 0.996 N 0.461 0.28 0.51196500227 gnomAD-2.1.1 3.18E-05 None None None None N None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
V/M 33354 Fn3-130 65 rs879221791 0.2371 -0.37 0.996 N 0.461 0.28 0.51196500227 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/M 33354 Fn3-130 65 rs879221791 0.2371 -0.37 0.996 N 0.461 0.28 0.51196500227 gnomAD-4.0.0 1.85979E-06 None None None None N None 2.67058E-05 0 None 0 0 None 0 0 8.47784E-07 0 0
I/F 33750 Fn3-132 62 rs1690954165 0.3526 None 0.9 N 0.503 0.172 None gnomAD-4.0.0 6.3642E-06 None None None None N None 0 0 None 0 0 None 7.53296E-05 0 0 0 0
I/T 33750 Fn3-132 62 None 0.3358 None 0.659 N 0.489 0.346 0.522717468363 gnomAD-4.0.0 1.36834E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79884E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.