Structural position:

  • Domain Type: Ig
  • Aligned Position: 115
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
G/S 53 Ig-1 48 rs150902810 0.1122 -1.021 1.0 N 0.729 0.392 None gnomAD-2.1.1 3.18E-05 None None None 0.231(TCAP) N None 6.15E-05 5.78E-05 None 0 5.45E-05 None 0 None 0 3.52E-05 0
G/S 53 Ig-1 48 rs150902810 0.1122 -1.021 1.0 N 0.729 0.392 None gnomAD-3.1.2 1.31E-05 None None None 0.231(TCAP) N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
G/S 53 Ig-1 48 rs150902810 0.1122 -1.021 1.0 N 0.729 0.392 None 1000 genomes 1.99681E-04 None None None 0.231(TCAP) N None 8E-04 0 None None 0 0 None None None 0 None
G/S 53 Ig-1 48 rs150902810 0.1122 -1.021 1.0 N 0.729 0.392 None gnomAD-4.0.0 7.43445E-06 None None None 0.231(TCAP) N None 1.3328E-05 3.33222E-05 None 0 0 None 0 0 2.54236E-06 3.29395E-05 4.79969E-05
G/V 53 Ig-1 48 None 0.4069 None 1.0 N 0.804 0.486 0.443999229985 gnomAD-4.0.0 3.42034E-06 None None None -0.001(TCAP) N None 0 0 None 0 0 None 0 0 3.59717E-06 0 1.65579E-05
D/N 149 Ig-2 46 rs1465558432 0.5779 -0.606 0.999 N 0.655 0.356 0.289098819767 gnomAD-2.1.1 1.19E-05 None None None -1.562(TCAP) N None 0 0 None 0 0 None 0 None 0 2.64E-05 0
D/N 149 Ig-2 46 rs1465558432 0.5779 -0.606 0.999 N 0.655 0.356 0.289098819767 gnomAD-4.0.0 5.47248E-06 None None None -1.562(TCAP) N None 0 0 None 0 0 None 0 0 7.19436E-06 0 0
D/N 988 Ig-3 46 None 0.8775 None 1.0 N 0.641 0.349 0.324161360171 gnomAD-4.0.0 1.36815E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7986E-06 0 0
R/G 1127 Ig-4 46 None 0.9816 None 1.0 N 0.716 0.601 0.53837629882 gnomAD-4.0.0 5.47276E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19463E-06 0 0
R/S 1336 Ig-5 46 rs1449428038 0.8549 -0.685 0.896 N 0.465 0.34 0.250579442822 gnomAD-2.1.1 4E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
R/S 1336 Ig-5 46 rs1449428038 0.8549 -0.685 0.896 N 0.465 0.34 0.250579442822 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
T/I 1502 Ig-6 46 None 0.4494 None 0.999 N 0.702 0.582 0.534093007224 gnomAD-4.0.0 1.36835E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79873E-06 0 0
T/N 1502 Ig-6 46 rs2092362672 0.1952 None 0.999 N 0.689 0.391 0.463243292966 gnomAD-4.0.0 1.36835E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79873E-06 0 0
K/N 1603 Ig-7 48 rs764249850 0.2026 -0.496 None N 0.095 0.099 0.166414681773 gnomAD-2.1.1 7.96E-06 None None None None N None 0 0 None 0 1.08873E-04 None 0 None 0 0 0
K/N 1603 Ig-7 48 rs764249850 0.2026 -0.496 None N 0.095 0.099 0.166414681773 gnomAD-4.0.0 1.5907E-06 None None None None N None 0 0 None 0 2.77346E-05 None 0 0 0 0 0
K/Q 1603 Ig-7 48 rs754087999 0.0977 -0.399 0.055 N 0.211 0.194 0.251116650651 gnomAD-2.1.1 2.39E-05 None None None None N None 0 1.15647E-04 None 0 0 None 0 None 0 1.76E-05 0
K/Q 1603 Ig-7 48 rs754087999 0.0977 -0.399 0.055 N 0.211 0.194 0.251116650651 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/Q 1603 Ig-7 48 rs754087999 0.0977 -0.399 0.055 N 0.211 0.194 0.251116650651 gnomAD-4.0.0 1.67287E-05 None None None None N None 0 4.99967E-05 None 0 0 None 0 0 1.94916E-05 1.09784E-05 0
K/T 1603 Ig-7 48 None 0.155 None 0.055 N 0.327 0.251 0.280181792013 gnomAD-4.0.0 1.59069E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85678E-06 0 0
R/S 1750 Ig-8 48 rs924534786 0.9804 None 1.0 D 0.751 0.526 0.604474940213 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/S 1750 Ig-8 48 rs924534786 0.9804 None 1.0 D 0.751 0.526 0.604474940213 gnomAD-4.0.0 6.5703E-06 None None None None I None 2.41243E-05 0 None 0 0 None 0 0 0 0 0
R/L 2123 Ig-10 46 rs530807674 0.6478 -0.264 1.0 D 0.689 0.768 0.704837425536 gnomAD-2.1.1 1.42E-05 None None None None N None 4.01E-05 0 None 0 0 None 6.53E-05 None 0 0 1.38812E-04
R/L 2123 Ig-10 46 rs530807674 0.6478 -0.264 1.0 D 0.689 0.768 0.704837425536 gnomAD-3.1.2 2.63E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 6.22148E-04 0
R/L 2123 Ig-10 46 rs530807674 0.6478 -0.264 1.0 D 0.689 0.768 0.704837425536 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
R/L 2123 Ig-10 46 rs530807674 0.6478 -0.264 1.0 D 0.689 0.768 0.704837425536 gnomAD-4.0.0 8.67428E-06 None None None None N None 1.33298E-05 0 None 0 0 None 0 0 0 1.31764E-04 1.59985E-05
R/Q 2123 Ig-10 46 rs530807674 0.187 -0.626 1.0 D 0.693 0.611 None gnomAD-2.1.1 3.19E-05 None None None None N None 1.84593E-04 0 None 0 0 None 9.8E-05 None 0 1.76E-05 0
R/Q 2123 Ig-10 46 rs530807674 0.187 -0.626 1.0 D 0.693 0.611 None gnomAD-3.1.2 5.26E-05 None None None None N None 1.93125E-04 0 0 0 0 None 0 0 0 0 0
R/Q 2123 Ig-10 46 rs530807674 0.187 -0.626 1.0 D 0.693 0.611 None gnomAD-4.0.0 2.2307E-05 None None None None N None 2.80381E-04 0 None 0 6.69225E-05 None 0 0 8.47462E-06 2.19597E-05 0
R/W 2123 Ig-10 46 rs777316854 0.6434 -0.586 1.0 D 0.7 0.756 0.663099739152 gnomAD-2.1.1 3.19E-05 None None None None N None 6.15E-05 2.9E-05 None 0 5.46E-05 None 3.27E-05 None 0 3.52E-05 0
R/W 2123 Ig-10 46 rs777316854 0.6434 -0.586 1.0 D 0.7 0.756 0.663099739152 gnomAD-3.1.2 3.94E-05 None None None None N None 9.66E-05 0 0 0 0 None 0 0 2.94E-05 0 0
R/W 2123 Ig-10 46 rs777316854 0.6434 -0.586 1.0 D 0.7 0.756 0.663099739152 gnomAD-4.0.0 1.17732E-05 None None None None N None 6.67735E-05 1.66778E-05 None 0 2.23035E-05 None 0 0 7.62711E-06 2.19602E-05 1.60046E-05
K/Q 2219 Ig-11 46 rs1292302676 0.459 -0.618 1.0 D 0.712 0.453 0.371718192555 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
K/Q 2219 Ig-11 46 rs1292302676 0.459 -0.618 1.0 D 0.712 0.453 0.371718192555 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/Q 2219 Ig-11 46 rs1292302676 0.459 -0.618 1.0 D 0.712 0.453 0.371718192555 gnomAD-4.0.0 3.84199E-06 None None None None N None 3.38192E-05 1.69463E-05 None 0 0 None 0 0 0 0 0
K/R 2219 Ig-11 46 rs1482793298 0.1443 -0.407 0.999 N 0.54 0.341 0.340510301474 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
K/R 2219 Ig-11 46 rs1482793298 0.1443 -0.407 0.999 N 0.54 0.341 0.340510301474 gnomAD-4.0.0 1.59078E-06 None None None None N None 0 2.28655E-05 None 0 0 None 0 0 0 0 0
K/N 2311 Ig-12 45 None 0.8041 None 1.0 N 0.699 0.246 0.0986583533028 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
R/G 2400 Ig-13 45 rs765593704 0.6766 -0.979 1.0 D 0.619 0.645 0.678023017383 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
R/G 2400 Ig-13 45 rs765593704 0.6766 -0.979 1.0 D 0.619 0.645 0.678023017383 gnomAD-4.0.0 3.1811E-06 None None None None N None 0 2.28676E-05 None 0 0 None 0 0 2.85662E-06 0 0
R/K 2400 Ig-13 45 None 0.2019 None 0.997 D 0.476 0.55 0.698733648705 gnomAD-4.0.0 3.18109E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86549E-05 0
R/S 2400 Ig-13 45 None 0.8473 None 1.0 D 0.633 0.581 0.483521307902 gnomAD-4.0.0 1.59056E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85662E-06 0 0
R/C 2490 Ig-14 46 rs200131545 0.5237 -0.117 1.0 D 0.636 0.462 0.524271286562 gnomAD-2.1.1 7.97E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 1.63239E-04
R/C 2490 Ig-14 46 rs200131545 0.5237 -0.117 1.0 D 0.636 0.462 0.524271286562 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 2490 Ig-14 46 rs200131545 0.5237 -0.117 1.0 D 0.636 0.462 0.524271286562 gnomAD-4.0.0 9.91432E-06 None None None None N None 0 0 None 0 0 None 0 0 1.27125E-05 0 1.60041E-05
R/H 2490 Ig-14 46 rs148920986 0.2485 -1.239 1.0 N 0.554 0.383 None gnomAD-2.1.1 2.83E-05 None None None None N None 4.01E-05 2.83E-05 None 0 0 None 0 None 0 3.88E-05 1.38543E-04
R/H 2490 Ig-14 46 rs148920986 0.2485 -1.239 1.0 N 0.554 0.383 None gnomAD-3.1.2 3.94E-05 None None None None N None 0 0 0 0 0 None 0 3.16456E-03 7.35E-05 0 0
R/H 2490 Ig-14 46 rs148920986 0.2485 -1.239 1.0 N 0.554 0.383 None gnomAD-4.0.0 1.7348E-05 None None None None N None 1.33298E-05 1.66683E-05 None 0 2.22955E-05 None 0 0 1.94921E-05 0 3.1998E-05
R/L 2490 Ig-14 46 rs148920986 0.7206 0.378 0.996 D 0.473 0.5 None gnomAD-2.1.1 7.97E-06 None None None None N None 1.23062E-04 0 None 0 0 None 0 None 0 0 0
R/L 2490 Ig-14 46 rs148920986 0.7206 0.378 0.996 D 0.473 0.5 None gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
R/L 2490 Ig-14 46 rs148920986 0.7206 0.378 0.996 D 0.473 0.5 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
R/L 2490 Ig-14 46 rs148920986 0.7206 0.378 0.996 D 0.473 0.5 None gnomAD-4.0.0 4.95657E-06 None None None None N None 7.99787E-05 0 None 0 0 None 0 0 0 0 3.1998E-05
R/P 2490 Ig-14 46 None 0.9786 None 1.0 D 0.553 0.597 0.449283877778 gnomAD-4.0.0 2.05233E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69796E-06 0 0
K/Q 2577 Ig-15 45 None 0.3281 None 1.0 D 0.703 0.305 0.236890367714 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
K/R 2577 Ig-15 45 rs1312348465 0.1149 -0.358 0.999 N 0.525 0.257 0.288727942641 gnomAD-2.1.1 7.99E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
K/R 2577 Ig-15 45 rs1312348465 0.1149 -0.358 0.999 N 0.525 0.257 0.288727942641 gnomAD-4.0.0 9.54651E-06 None None None None N None 0 1.14432E-04 None 0 0 None 0 0 0 0 3.02316E-05
K/N 2752 Ig-17 46 rs1253422827 0.6078 -0.913 1.0 D 0.7 0.484 0.40417439687 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/N 2752 Ig-17 46 rs1253422827 0.6078 -0.913 1.0 D 0.7 0.484 0.40417439687 gnomAD-4.0.0 3.18098E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86541E-05 0
K/N 3013 Ig-20 45 None 0.8125 None 0.117 N 0.317 0.073 0.0762999501168 gnomAD-4.0.0 6.84088E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99295E-07 0 0
R/G 3102 Ig-21 45 None 0.5863 None 0.996 D 0.435 0.624 0.690363523209 gnomAD-4.0.0 1.59055E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02151E-05
R/K 3102 Ig-21 45 None 0.2325 None 0.991 N 0.399 0.357 0.394384168047 gnomAD-4.0.0 1.59056E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85651E-06 0 0
R/P 3193 Ig-22 47 None 0.9332 None 1.0 D 0.664 0.718 0.671041724158 gnomAD-4.0.0 6.84089E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99311E-07 0 0
R/Q 3193 Ig-22 47 rs1034071730 0.3149 -0.164 1.0 D 0.684 0.551 0.467585353272 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.63239E-04
R/Q 3193 Ig-22 47 rs1034071730 0.3149 -0.164 1.0 D 0.684 0.551 0.467585353272 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/Q 3193 Ig-22 47 rs1034071730 0.3149 -0.164 1.0 D 0.684 0.551 0.467585353272 gnomAD-4.0.0 1.98273E-05 None None None None N None 0 0 None 0 2.22886E-05 None 0 0 2.37289E-05 0 4.80138E-05
K/R 3284 Ig-23 46 rs147903846 0.2944 -0.122 0.999 N 0.523 0.204 None gnomAD-2.1.1 5.67E-05 None None None None N None 4.01E-05 0 None 0 0 None 3.27E-05 None 0 1.08699E-04 0
K/R 3284 Ig-23 46 rs147903846 0.2944 -0.122 0.999 N 0.523 0.204 None gnomAD-3.1.2 5.26E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 8.82E-05 0 4.78011E-04
K/R 3284 Ig-23 46 rs147903846 0.2944 -0.122 0.999 N 0.523 0.204 None gnomAD-4.0.0 9.04528E-05 None None None None N None 1.33255E-05 0 None 0 0 None 0 3.30142E-04 1.13562E-04 0 1.43982E-04
D/E 3510 Ig-25 46 None 0.261 None None None None 0.033 None gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
D/Y 3510 Ig-25 46 rs770135769 0.4051 0.71 None None None 0.24 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/Y 3510 Ig-25 46 rs770135769 0.4051 0.71 None None None 0.24 None gnomAD-4.0.0 2.56212E-06 None None None None N None 0 0 None 0 0 None 0 0 2.39287E-06 1.33998E-05 0
R/K 3705 Ig-26 46 rs2086934731 0.1528 None None None None 0.074 None gnomAD-4.0.0 6.84195E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99442E-07 0 0
R/T 3705 Ig-26 46 None 0.2953 None None None None 0.151 None gnomAD-4.0.0 6.84195E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15937E-05 0
K/E 4649 Ig-29 44 rs1060500392 0.1405 None None N 0.047 0.107 0.136095386433 gnomAD-4.0.0 6.84606E-06 None None None None N None 0 0 None 0 0 None 0 0 8.09924E-06 0 1.65772E-05
K/N 4649 Ig-29 44 rs1574063706 0.2082 None 0.001 N 0.072 0.147 0.117506650769 gnomAD-4.0.0 1.36939E-06 None None None None N None 0 0 None 0 0 None 0 0 9.00019E-07 0 1.65815E-05
K/M 4745 Ig-30 46 None 0.8198 None 1.0 N 0.703 0.399 0.252162846088 gnomAD-4.0.0 1.59166E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85847E-06 0 0
K/N 4745 Ig-30 46 rs756868442 0.8814 None 1.0 N 0.728 0.237 0.154104182512 gnomAD-4.0.0 6.8428E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99489E-07 0 0
K/R 4745 Ig-30 46 rs778762576 0.121 -0.18 0.999 N 0.522 0.244 0.188950314367 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.61E-05 None 0 None 0 0 0
K/R 4745 Ig-30 46 rs778762576 0.121 -0.18 0.999 N 0.522 0.244 0.188950314367 gnomAD-4.0.0 1.59166E-06 None None None None N None 0 0 None 0 2.78071E-05 None 0 0 0 0 0
N/H 4840 Ig-31 46 rs199997460 0.0795 -1.133 None N 0.174 0.042 None gnomAD-2.1.1 7.85E-05 None None None None N None 0 2.83E-05 None 0 0 None 0 None 7.99E-05 1.48204E-04 0
N/H 4840 Ig-31 46 rs199997460 0.0795 -1.133 None N 0.174 0.042 None gnomAD-3.1.2 7.89E-05 None None None None N None 0 6.55E-05 0 0 0 None 1.88324E-04 0 1.32298E-04 0 0
N/H 4840 Ig-31 46 rs199997460 0.0795 -1.133 None N 0.174 0.042 None gnomAD-4.0.0 1.25175E-04 None None None None N None 0 1.66722E-05 None 0 0 None 1.24961E-04 0 1.59347E-04 0 8.00615E-05
N/K 4840 Ig-31 46 rs1162232624 0.1481 None None N 0.18 0.097 0.0551355673512 gnomAD-4.0.0 1.59111E-06 None None None None N None 5.65291E-05 0 None 0 0 None 0 0 0 0 0
N/T 4840 Ig-31 46 rs779078589 0.0986 -0.687 None N 0.16 0.062 0.104622674875 gnomAD-2.1.1 1.43E-05 None None None None N None 0 8.49E-05 None 0 0 None 0 None 0 0 1.40331E-04
N/T 4840 Ig-31 46 rs779078589 0.0986 -0.687 None N 0.16 0.062 0.104622674875 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.78927E-04
N/T 4840 Ig-31 46 rs779078589 0.0986 -0.687 None N 0.16 0.062 0.104622674875 gnomAD-4.0.0 2.56203E-06 None None None None N None 0 1.69509E-05 None 0 0 None 0 0 0 0 2.84398E-05
D/Y 4933 Ig-32 46 rs984284016 0.2106 0.115 1.0 N 0.718 0.365 0.439445477881 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
D/Y 4933 Ig-32 46 rs984284016 0.2106 0.115 1.0 N 0.718 0.365 0.439445477881 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/Y 4933 Ig-32 46 rs984284016 0.2106 0.115 1.0 N 0.718 0.365 0.439445477881 gnomAD-4.0.0 6.57056E-06 None None None None N None 2.41173E-05 0 None 0 0 None 0 0 0 0 0
T/I 5027 Ig-33 47 rs778591734 0.1732 -0.224 0.996 N 0.381 0.287 0.329020015101 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.56E-05 0
T/K 5027 Ig-33 47 None 0.1088 None 0.061 N 0.187 0.219 0.1749357433 gnomAD-4.0.0 1.36849E-06 None None None None N None 0 0 None 0 2.52118E-05 None 0 0 0 0 1.65673E-05
K/N 5213 Ig-35 46 rs2080952653 0.1461 None 0.005 N 0.087 0.065 0.0666544352282 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/N 5213 Ig-35 46 rs2080952653 0.1461 None 0.005 N 0.087 0.065 0.0666544352282 gnomAD-4.0.0 6.57445E-06 None None None None N None 2.41429E-05 0 None 0 0 None 0 0 0 0 0
R/T 5402 Ig-37 46 rs886042411 0.1382 -0.706 0.024 N 0.317 0.241 0.272205846399 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
R/T 5402 Ig-37 46 rs886042411 0.1382 -0.706 0.024 N 0.317 0.241 0.272205846399 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
R/T 5402 Ig-37 46 rs886042411 0.1382 -0.706 0.024 N 0.317 0.241 0.272205846399 gnomAD-4.0.0 7.43721E-06 None None None None N None 1.33479E-05 0 None 0 0 None 0 0 9.32395E-06 0 0
S/G 5495 Ig-38 46 None 0.0738 None 0.012 N 0.293 0.1 0.112648838833 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/N 5495 Ig-38 46 rs1183828555 0.0617 0.122 None N 0.265 0.038 0.0401082797425 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
S/N 5495 Ig-38 46 rs1183828555 0.0617 0.122 None N 0.265 0.038 0.0401082797425 gnomAD-4.0.0 1.36851E-06 None None None None N None 0 0 None 0 0 None 0 0 1.799E-06 0 0
S/T 5495 Ig-38 46 rs1183828555 0.0789 -0.013 None N 0.105 0.047 0.0482279557977 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
N/S 5775 Ig-41 46 rs1347227022 0.0793 -0.294 0.549 N 0.373 0.144 0.126345400529 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 2.87687E-04 0 0
N/S 5775 Ig-41 46 rs1347227022 0.0793 -0.294 0.549 N 0.373 0.144 0.126345400529 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.42E-05 0 0 0 0
N/S 5775 Ig-41 46 rs1347227022 0.0793 -0.294 0.549 N 0.373 0.144 0.126345400529 gnomAD-4.0.0 5.1246E-06 None None None None N None 0 0 None 0 0 None 6.27569E-05 0 0 0 0
N/T 5775 Ig-41 46 None 0.1113 None 0.712 N 0.388 0.149 0.186928172975 gnomAD-4.0.0 4.77395E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71647E-06 1.43279E-05 0
K/E 6244 Ig-46 46 None 0.6127 None 0.996 N 0.418 0.29 0.277317399466 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/N 6244 Ig-46 46 None 0.6365 None 0.884 N 0.257 0.179 0.0297737177859 gnomAD-4.0.0 1.5916E-06 None None None None N None 0 0 None 0 2.77316E-05 None 0 0 0 0 0
K/R 6244 Ig-46 46 rs1448766260 0.1138 -0.378 0.998 N 0.501 0.186 0.17258766438 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/R 6244 Ig-46 46 rs1448766260 0.1138 -0.378 0.998 N 0.501 0.186 0.17258766438 gnomAD-4.0.0 1.5916E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.0248E-05
N/S 6337 Ig-47 46 None 0.0841 None 0.065 N 0.122 0.105 0.0884992946249 gnomAD-4.0.0 1.59328E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43484E-05 0
Y/C 6430 Ig-48 46 rs781726929 0.3032 -0.198 0.997 N 0.363 0.423 0.430808444494 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 2.23989E-04 None 0 None 0 0 0
Y/C 6430 Ig-48 46 rs781726929 0.3032 -0.198 0.997 N 0.363 0.423 0.430808444494 gnomAD-4.0.0 2.7377E-06 None None None None N None 0 0 None 0 5.04898E-05 None 0 0 1.79923E-06 0 0
K/E 6619 Ig-50 46 rs1060500450 0.1078 0.559 0.052 N 0.279 0.17 0.20549828249 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
K/E 6619 Ig-50 46 rs1060500450 0.1078 0.559 0.052 N 0.279 0.17 0.20549828249 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
K/E 6619 Ig-50 46 rs1060500450 0.1078 0.559 0.052 N 0.279 0.17 0.20549828249 gnomAD-4.0.0 1.1536E-05 None None None None N None 0 0 None 0 0 None 0 0 2.15532E-05 0 0
K/T 6619 Ig-50 46 rs368720026 0.1028 -0.275 None N 0.109 0.105 None gnomAD-2.1.1 8.04E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 1.65728E-04
K/T 6619 Ig-50 46 rs368720026 0.1028 -0.275 None N 0.109 0.105 None gnomAD-3.1.2 5.92E-05 None None None None N None 1.93087E-04 6.56E-05 0 0 0 None 0 0 0 0 0
K/T 6619 Ig-50 46 rs368720026 0.1028 -0.275 None N 0.109 0.105 None gnomAD-4.0.0 1.79463E-05 None None None None N None 1.69279E-04 5.08613E-05 None 0 0 None 0 0 2.39479E-06 0 0
K/N 6713 Ig-51 47 rs375668907 0.4283 -0.346 0.099 N 0.159 0.08 0.0611884634855 gnomAD-2.1.1 8.05E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.9E-06 0
K/N 6713 Ig-51 47 rs375668907 0.4283 -0.346 0.099 N 0.159 0.08 0.0611884634855 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
K/N 6713 Ig-51 47 rs375668907 0.4283 -0.346 0.099 N 0.159 0.08 0.0611884634855 gnomAD-4.0.0 1.5498E-05 None None None None N None 0 3.33723E-05 None 0 2.23085E-05 None 0 0 1.78049E-05 0 1.60159E-05
K/T 6713 Ig-51 47 rs1410340266 0.1998 -0.607 0.712 N 0.409 0.336 0.257292322809 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66389E-04
K/T 6713 Ig-51 47 rs1410340266 0.1998 -0.607 0.712 N 0.409 0.336 0.257292322809 gnomAD-4.0.0 3.18491E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86056E-06 0 3.0259E-05
K/N 6806 Ig-52 46 rs768932465 0.8154 -0.628 0.957 N 0.213 0.272 0.237489013734 gnomAD-2.1.1 1.00171E-04 None None None None N None 0 2.8393E-04 None 0 0 None 0 None 0 1.40887E-04 0
K/N 6806 Ig-52 46 rs768932465 0.8154 -0.628 0.957 N 0.213 0.272 0.237489013734 gnomAD-3.1.2 8.54E-05 None None None None N None 2.41E-05 1.96644E-04 0 0 0 None 0 0 1.32306E-04 0 0
K/N 6806 Ig-52 46 rs768932465 0.8154 -0.628 0.957 N 0.213 0.272 0.237489013734 gnomAD-4.0.0 9.91814E-05 None None None None N None 1.33308E-05 3.00411E-04 None 0 0 None 0 1.6518E-04 1.1361E-04 1.09851E-05 8.00871E-05
K/T 6806 Ig-52 46 None 0.6898 None 0.995 N 0.465 0.485 0.575946966538 gnomAD-4.0.0 1.59285E-06 None None None None N None 0 0 None 0 0 None 0 2.41546E-04 0 0 0
N/K 6900 Ig-53 47 None 0.495 None 0.998 N 0.564 0.197 0.0920862733494 gnomAD-4.0.0 3.42199E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49822E-06 0 0
N/S 6900 Ig-53 47 rs1389235832 0.1683 None 0.998 N 0.383 0.217 0.117506650769 gnomAD-4.0.0 1.59226E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86015E-06 0 0
R/G 7182 Ig-56 46 None 0.0759 None 0.008 N 0.206 0.056 0.223146558224 gnomAD-4.0.0 6.84392E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9962E-07 0 0
R/Q 7182 Ig-56 46 rs200447686 0.0703 0.088 None N 0.115 0.068 None gnomAD-2.1.1 5.36E-05 None None None None N None 1.2409E-04 5.67E-05 None 0 1.02796E-04 None 0 None 0 5.47E-05 1.40805E-04
R/Q 7182 Ig-56 46 rs200447686 0.0703 0.088 None N 0.115 0.068 None gnomAD-3.1.2 5.26E-05 None None None None N None 1.20703E-04 0 0 0 0 None 0 0 2.94E-05 0 4.79386E-04
R/Q 7182 Ig-56 46 rs200447686 0.0703 0.088 None N 0.115 0.068 None gnomAD-4.0.0 7.00453E-05 None None None None N None 1.20205E-04 1.1676E-04 None 0 4.4615E-05 None 0 4.93259E-04 7.37552E-05 0 8.01077E-05
R/W 7182 Ig-56 46 rs727504736 0.1064 -0.319 0.941 N 0.322 0.14 None gnomAD-2.1.1 9.26E-05 None None None None N None 6.47E-05 5.23073E-04 None 0 5.59E-05 None 0 None 0 2.67E-05 0
R/W 7182 Ig-56 46 rs727504736 0.1064 -0.319 0.941 N 0.322 0.14 None gnomAD-3.1.2 3.29E-05 None None None None N None 2.41E-05 6.55E-05 0 0 0 None 0 0 4.41E-05 0 0
R/W 7182 Ig-56 46 rs727504736 0.1064 -0.319 0.941 N 0.322 0.14 None gnomAD-4.0.0 4.27725E-05 None None None None N None 2.67151E-05 4.17056E-04 None 0 2.23085E-05 None 0 0 3.30631E-05 0 3.2039E-05
E/A 7368 Ig-58 46 rs1420368632 0.089 -0.715 0.454 N 0.292 0.078 0.18995819373 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
E/A 7368 Ig-58 46 rs1420368632 0.089 -0.715 0.454 N 0.292 0.078 0.18995819373 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/A 7368 Ig-58 46 rs1420368632 0.089 -0.715 0.454 N 0.292 0.078 0.18995819373 gnomAD-4.0.0 8.6782E-06 None None None None N None 0 0 None 0 0 None 0 0 1.18687E-05 0 0
E/Q 7368 Ig-58 46 None 0.1129 None 0.801 N 0.381 0.162 0.132336055621 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
N/D 7464 Ig-59 46 rs879082137 0.2652 None 0.805 N 0.437 0.161 0.233785782151 gnomAD-4.0.0 1.36869E-05 None None None None N None 0 0 None 0 0 None 0 0 1.79925E-05 0 0
N/D 7560 Ig-60 46 None 0.5236 None 0.943 N 0.403 0.218 0.173771789658 gnomAD-4.0.0 1.59173E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85941E-06 0 0
N/D 7841 Ig-63 47 rs753072306 0.1438 0.068 0.256 N 0.423 0.11 0.166414681773 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
N/Y 7841 Ig-63 47 rs753072306 0.1853 -0.666 0.997 N 0.491 0.436 0.228597637076 gnomAD-2.1.1 2.5E-05 None None None None N None 0 0 None 0 3.58643E-04 None 0 None 0 0 0
N/Y 7841 Ig-63 47 rs753072306 0.1853 -0.666 0.997 N 0.491 0.436 0.228597637076 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92456E-04 None 0 0 0 0 0
N/Y 7841 Ig-63 47 rs753072306 0.1853 -0.666 0.997 N 0.491 0.436 0.228597637076 gnomAD-4.0.0 7.43641E-06 None None None None N None 0 0 None 0 2.45043E-04 None 0 0 0 0 1.60123E-05
S/L 8123 Ig-66 46 rs879096365 0.0866 -0.219 0.062 N 0.349 0.104 None gnomAD-2.1.1 8.05E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 8.9E-06 0
S/L 8123 Ig-66 46 rs879096365 0.0866 -0.219 0.062 N 0.349 0.104 None gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
S/L 8123 Ig-66 46 rs879096365 0.0866 -0.219 0.062 N 0.349 0.104 None gnomAD-4.0.0 9.2958E-06 None None None None N None 5.3416E-05 0 None 0 0 None 0 0 9.32398E-06 0 0
S/P 8123 Ig-66 46 rs1407865752 0.1521 -0.286 0.317 N 0.43 0.102 0.0920862733494 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
S/P 8123 Ig-66 46 rs1407865752 0.1521 -0.286 0.317 N 0.43 0.102 0.0920862733494 gnomAD-4.0.0 1.5913E-06 None None None None N None 0 0 None 0 2.77408E-05 None 0 0 0 0 0
R/K 8216 Ig-67 46 rs561781856 0.0687 -0.458 None N 0.073 0.094 0.0611884634855 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
R/K 8216 Ig-67 46 rs561781856 0.0687 -0.458 None N 0.073 0.094 0.0611884634855 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
R/K 8216 Ig-67 46 rs561781856 0.0687 -0.458 None N 0.073 0.094 0.0611884634855 gnomAD-4.0.0 2.56192E-06 None None None None N None 0 3.38857E-05 None 0 0 None 0 0 0 0 0
R/S 8216 Ig-67 46 None 0.14 None None N 0.149 0.131 0.0297737177859 gnomAD-4.0.0 6.84222E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99486E-07 0 0
A/E 8309 Ig-68 46 rs186598275 0.256 -0.496 0.965 N 0.345 0.26 0.445007932271 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.56E-05 None 0 None 0 0 0
A/E 8309 Ig-68 46 rs186598275 0.256 -0.496 0.965 N 0.345 0.26 0.445007932271 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92976E-04 None 0 0 0 0 0
A/E 8309 Ig-68 46 rs186598275 0.256 -0.496 0.965 N 0.345 0.26 0.445007932271 gnomAD-4.0.0 6.5678E-06 None None None None N None 0 0 None 0 1.93424E-04 None 0 0 0 0 0
A/V 8309 Ig-68 46 rs186598275 0.1359 -0.202 0.965 N 0.323 0.259 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
A/V 8309 Ig-68 46 rs186598275 0.1359 -0.202 0.965 N 0.323 0.259 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/V 8309 Ig-68 46 rs186598275 0.1359 -0.202 0.965 N 0.323 0.259 None gnomAD-4.0.0 6.5678E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4705E-05 0 0
N/K 8405 Ig-69 46 rs371923232 0.4957 -0.094 0.649 N 0.205 0.141 0.168933306366 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
N/K 8405 Ig-69 46 rs371923232 0.4957 -0.094 0.649 N 0.205 0.141 0.168933306366 gnomAD-4.0.0 1.11566E-05 None None None None N None 1.33483E-05 0 None 0 0 None 0 0 1.35637E-05 0 1.60154E-05
N/K 8501 Ig-70 46 rs758559820 0.8055 0.453 0.388 N 0.178 0.087 0.115124310173 gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 1.65782E-04
N/K 8501 Ig-70 46 rs758559820 0.8055 0.453 0.388 N 0.178 0.087 0.115124310173 gnomAD-4.0.0 5.47423E-06 None None None None N None 0 0 None 0 0 None 0 0 0 8.11557E-05 1.657E-05
K/N 8595 Ig-71 47 None 0.496 None 0.019 N 0.073 0.06 0.0806252709748 gnomAD-4.0.0 1.59172E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85914E-06 0 0
K/Q 8595 Ig-71 47 None 0.2158 None 0.006 N 0.189 0.184 0.104622674875 gnomAD-4.0.0 1.36859E-06 None None None None N None 0 4.47507E-05 None 0 0 None 0 0 0 0 0
K/R 8595 Ig-71 47 rs774140425 0.0849 -0.301 0.241 N 0.285 0.09 0.119812018005 gnomAD-2.1.1 2.01E-05 None None None None N None 0 1.16117E-04 None 0 0 None 0 None 0 8.88E-06 0
K/R 8595 Ig-71 47 rs774140425 0.0849 -0.301 0.241 N 0.285 0.09 0.119812018005 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
K/R 8595 Ig-71 47 rs774140425 0.0849 -0.301 0.241 N 0.285 0.09 0.119812018005 gnomAD-4.0.0 1.66584E-05 None None None None N None 0 1.01764E-04 None 0 0 None 0 0 7.18119E-06 0 1.13824E-04
N/S 8782 Ig-73 47 rs727504895 0.0864 None 0.03 N 0.115 0.094 0.0846915920261 gnomAD-4.0.0 1.36848E-06 None None None None N None 0 0 None 0 2.51915E-05 None 0 0 8.99501E-07 0 0
N/Y 8782 Ig-73 47 rs1017848590 0.2031 None 1.0 N 0.52 0.35 0.39724302092 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
N/Y 8782 Ig-73 47 rs1017848590 0.2031 None 1.0 N 0.52 0.35 0.39724302092 gnomAD-4.0.0 9.29567E-06 None None None None N None 0 0 None 0 0 None 0 0 1.1867E-05 0 1.60118E-05
K/I 8875 Ig-74 46 rs1472784946 0.5713 None 1.0 N 0.641 0.454 0.496036935653 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
K/I 8875 Ig-74 46 rs1472784946 0.5713 None 1.0 N 0.641 0.454 0.496036935653 gnomAD-4.0.0 1.31463E-05 None None None None N None 0 0 None 0 0 None 0 0 2.94048E-05 0 0
K/E 8971 Ig-75 46 rs373877046 0.5852 0.218 0.92 N 0.364 0.257 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
K/E 8971 Ig-75 46 rs373877046 0.5852 0.218 0.92 N 0.364 0.257 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/E 8971 Ig-75 46 rs373877046 0.5852 0.218 0.92 N 0.364 0.257 None gnomAD-4.0.0 1.98335E-05 None None None None N None 0 0 None 0 0 None 0 0 2.71257E-05 0 0
K/N 8971 Ig-75 46 None 0.7184 None 0.061 N 0.126 0.123 0.0611884634855 gnomAD-4.0.0 2.73724E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59811E-06 0 0
R/G 9635 Ig-82 46 rs397517531 0.1689 None 0.024 None 0.287 0.199 0.310458034454 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
R/G 9635 Ig-82 46 rs397517531 0.1689 None 0.024 None 0.287 0.199 0.310458034454 gnomAD-4.0.0 3.42088E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79882E-06 2.31884E-05 1.65645E-05
R/C 9744 Ig-83 47 rs375266859 0.9563 -0.896 1.0 None 0.711 0.414 None gnomAD-2.1.1 5.35E-05 None None None None N None 0 0 None 1.93162E-04 0 None 3.27E-05 None 0 9.34E-05 0
R/C 9744 Ig-83 47 rs375266859 0.9563 -0.896 1.0 None 0.711 0.414 None gnomAD-3.1.2 5.26E-05 None None None None N None 0 0 0 2.88351E-04 0 None 0 0 8.82E-05 2.07814E-04 0
R/C 9744 Ig-83 47 rs375266859 0.9563 -0.896 1.0 None 0.711 0.414 None gnomAD-4.0.0 4.27588E-05 None None None None N None 0 3.33456E-05 None 1.35153E-04 0 None 0 0 5.17018E-05 1.09808E-05 1.60092E-05
R/G 9744 Ig-83 47 rs375266859 0.9663 None 1.0 None 0.675 0.531 0.418964662724 gnomAD-4.0.0 6.84162E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99425E-07 0 0
R/H 9744 Ig-83 47 rs760305440 0.7704 -1.388 1.0 None 0.675 0.502 None gnomAD-2.1.1 1.78E-05 None None None None N None 4.14E-05 0 None 0 0 None 0 None 0 3.12E-05 0
R/H 9744 Ig-83 47 rs760305440 0.7704 -1.388 1.0 None 0.675 0.502 None gnomAD-3.1.2 5.26E-05 None None None None N None 4.83E-05 1.30993E-04 0 0 0 None 0 0 5.88E-05 0 0
R/H 9744 Ig-83 47 rs760305440 0.7704 -1.388 1.0 None 0.675 0.502 None Arimura (2009) Lopes (2013) None HCM het None None N Increases binding of TTN to CARP (Co-IP assay); alters subcellular localisation of CARP (Myc-tag) None None None None None None None None None None None
R/H 9744 Ig-83 47 rs760305440 0.7704 -1.388 1.0 None 0.675 0.502 None gnomAD-4.0.0 5.26723E-05 None None None None N None 2.67044E-05 5.00067E-05 None 0 2.22787E-05 None 0 1.64366E-04 6.10253E-05 2.19573E-05 6.40451E-05
K/N 9946 Ig-84 47 rs1181662412 0.7959 -0.464 0.993 None 0.686 0.287 0.119812018005 gnomAD-2.1.1 8.13E-06 None None None None N None 0 0 None 0 1.126E-04 None 0 None 0 0 0
K/N 9946 Ig-84 47 rs1181662412 0.7959 -0.464 0.993 None 0.686 0.287 0.119812018005 gnomAD-4.0.0 1.59444E-06 None None None None N None 0 0 None 0 2.77331E-05 None 0 0 0 0 0
K/T 9946 Ig-84 47 rs1268571982 0.5363 -0.684 0.993 None 0.684 0.414 0.330589388543 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 5.63E-05 None 0 None 0 0 0
K/N 13731 Ig-87 48 rs559968058 0.9709 -0.473 1.0 N 0.703 0.265 0.184867976434 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
K/N 13731 Ig-87 48 rs559968058 0.9709 -0.473 1.0 N 0.703 0.265 0.184867976434 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/N 13731 Ig-87 48 rs559968058 0.9709 -0.473 1.0 N 0.703 0.265 0.184867976434 gnomAD-4.0.0 6.57644E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47106E-05 0 0
R/G 13825 Ig-88 46 None 0.3002 None 0.058 N 0.345 0.105 0.0884992946249 gnomAD-4.0.0 4.10659E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39793E-06 0 0
R/L 13825 Ig-88 46 rs727504774 0.2845 0.088 0.058 N 0.395 0.064 0.0884992946249 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 8.9E-06 0
R/L 13825 Ig-88 46 rs727504774 0.2845 0.088 0.058 N 0.395 0.064 0.0884992946249 gnomAD-4.0.0 6.84428E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99648E-07 0 0
R/Q 13825 Ig-88 46 rs727504774 0.1159 -0.209 0.142 N 0.272 0.057 0.0611884634855 gnomAD-2.1.1 2.5E-05 None None None None N None 1.65399E-04 5.66E-05 None 0 5.18E-05 None 0 None 0 0 0
R/Q 13825 Ig-88 46 rs727504774 0.1159 -0.209 0.142 N 0.272 0.057 0.0611884634855 gnomAD-3.1.2 3.29E-05 None None None None N None 7.25E-05 0 0 0 0 None 0 0 2.94E-05 0 0
R/Q 13825 Ig-88 46 rs727504774 0.1159 -0.209 0.142 N 0.272 0.057 0.0611884634855 gnomAD-4.0.0 2.60376E-05 None None None None N None 9.35254E-05 3.33667E-05 None 0 2.23754E-05 None 0 1.64582E-04 2.54339E-05 0 1.60154E-05
K/Q 13920 Ig-89 45 None 0.5278 None 0.999 D 0.724 0.355 0.215109475489 gnomAD-4.0.0 6.93226E-07 None None None None N None 0 0 None 0 0 None 0 0 9.08102E-07 0 0
K/R 13920 Ig-89 45 rs751156425 0.1391 0.016 0.997 N 0.637 0.194 0.219573609325 gnomAD-2.1.1 9.15E-06 None None None None N None 0 0 None 0 0 None 7.25E-05 None 0 0 0
K/R 13920 Ig-89 45 rs751156425 0.1391 0.016 0.997 N 0.637 0.194 0.219573609325 gnomAD-4.0.0 3.281E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.96824E-05 0
T/K 14186 Ig-92 45 rs369771893 0.2961 -0.619 1.0 N 0.653 0.427 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
T/K 14186 Ig-92 45 rs369771893 0.2961 -0.619 1.0 N 0.653 0.427 None gnomAD-4.0.0 2.47945E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39104E-06 0 0
T/P 14186 Ig-92 45 rs1187615662 0.4122 -0.348 1.0 N 0.625 0.486 0.32471235697 gnomAD-4.0.0 1.59192E-06 None None None None N None 0 2.28676E-05 None 0 0 None 0 0 0 0 0
T/R 14186 Ig-92 45 None 0.2714 None 1.0 N 0.626 0.417 0.324436698001 gnomAD-4.0.0 6.84335E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99616E-07 0 0
K/N 14274 Ig-93 44 rs2060064294 0.5391 None 0.001 N 0.129 0.033 0.0401082797425 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/N 14274 Ig-93 44 rs2060064294 0.5391 None 0.001 N 0.129 0.033 0.0401082797425 gnomAD-4.0.0 6.57384E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4708E-05 0 0
D/N 14363 Ig-94 45 rs745979661 0.0843 -0.212 0.015 N 0.213 0.094 0.104622674875 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.62E-05 None 0 None 0 0 0
D/N 14363 Ig-94 45 rs745979661 0.0843 -0.212 0.015 N 0.213 0.094 0.104622674875 gnomAD-4.0.0 1.5943E-06 None None None None N None 0 0 None 0 2.78567E-05 None 0 0 0 0 0
D/Y 14363 Ig-94 45 rs745979661 0.1955 -0.444 0.994 D 0.674 0.254 0.418344901717 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
D/Y 14363 Ig-94 45 rs745979661 0.1955 -0.444 0.994 D 0.674 0.254 0.418344901717 gnomAD-4.0.0 1.5943E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02975E-05
R/G 14452 Ig-95 45 rs367791276 0.1635 -1.537 0.024 D 0.255 0.51 None gnomAD-2.1.1 4.04E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
R/G 14452 Ig-95 45 rs367791276 0.1635 -1.537 0.024 D 0.255 0.51 None gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/G 14452 Ig-95 45 rs367791276 0.1635 -1.537 0.024 D 0.255 0.51 None gnomAD-4.0.0 6.57514E-06 None None None None N None 2.41301E-05 0 None 0 0 None 0 0 0 0 0
R/I 14452 Ig-95 45 rs528741819 0.1906 -0.188 0.171 D 0.471 0.451 0.356690202451 gnomAD-3.1.2 5.26E-05 None None None None N None 2.41E-05 4.59016E-04 0 0 0 None 0 0 0 0 0
R/I 14452 Ig-95 45 rs528741819 0.1906 -0.188 0.171 D 0.471 0.451 0.356690202451 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
R/I 14452 Ig-95 45 rs528741819 0.1906 -0.188 0.171 D 0.471 0.451 0.356690202451 gnomAD-4.0.0 8.67692E-06 None None None None N None 1.33308E-05 1.83388E-04 None 0 0 None 0 0 0 0 3.20195E-05
R/K 14452 Ig-95 45 None 0.0665 None None N 0.066 0.255 0.128392430309 gnomAD-4.0.0 6.84321E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99612E-07 0 0
R/S 14452 Ig-95 45 rs374231453 0.3011 -1.176 0.012 D 0.283 0.248 0.290962096972 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
R/S 14452 Ig-95 45 rs374231453 0.3011 -1.176 0.012 D 0.283 0.248 0.290962096972 gnomAD-4.0.0 6.84312E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99603E-07 0 0
S/L 14541 Ig-96 45 rs768180052 0.0774 -0.282 None N 0.154 0.284 0.149567049428 gnomAD-2.1.1 8.25E-06 None None None None N None 0 0 None 0 0 None 3.37E-05 None 0 9.11E-06 0
S/L 14541 Ig-96 45 rs768180052 0.0774 -0.282 None N 0.154 0.284 0.149567049428 gnomAD-4.0.0 5.4887E-06 None None None None N None 0 4.52202E-05 None 0 0 None 0 0 3.60387E-06 2.33907E-05 0
K/E 14808 Ig-99 44 None 0.1632 None 0.09 N 0.263 0.194 0.18995819373 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
K/N 14808 Ig-99 44 rs762657962 0.2719 0.043 0.324 N 0.297 0.105 0.117506650769 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
K/N 14808 Ig-99 44 rs762657962 0.2719 0.043 0.324 N 0.297 0.105 0.117506650769 gnomAD-4.0.0 1.59544E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86466E-06 0 0
K/T 14808 Ig-99 44 rs374419129 0.1135 -0.31 0.001 N 0.191 0.126 None gnomAD-2.1.1 4.3E-05 None None None None N None 1.6559E-04 1.99022E-04 None 0 0 None 3.28E-05 None 0 0 0
K/T 14808 Ig-99 44 rs374419129 0.1135 -0.31 0.001 N 0.191 0.126 None gnomAD-3.1.2 7.23E-05 None None None None N None 2.17181E-04 6.55E-05 0 0 0 None 0 0 0 0 4.79386E-04
K/T 14808 Ig-99 44 rs374419129 0.1135 -0.31 0.001 N 0.191 0.126 None 1000 genomes 3.99361E-04 None None None None N None 8E-04 1.4E-03 None None 0 0 None None None 0 None
K/T 14808 Ig-99 44 rs374419129 0.1135 -0.31 0.001 N 0.191 0.126 None gnomAD-4.0.0 4.89972E-05 None None None None N None 6.26934E-04 1.16787E-04 None 0 0 None 0 3.30688E-04 5.08886E-06 1.09982E-05 2.56451E-04
R/C 15346 Ig-105 45 rs767343871 0.4547 -0.064 1.0 D 0.71 0.407 0.685456958132 gnomAD-2.1.1 2.15E-05 None None None None N None 4.14E-05 0 None 0 5.17E-05 None 1.30813E-04 None 0 0 0
R/C 15346 Ig-105 45 rs767343871 0.4547 -0.064 1.0 D 0.71 0.407 0.685456958132 gnomAD-3.1.2 1.32E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 2.07987E-04 0
R/C 15346 Ig-105 45 rs767343871 0.4547 -0.064 1.0 D 0.71 0.407 0.685456958132 gnomAD-4.0.0 1.05446E-05 None None None None N None 2.67451E-05 1.67084E-05 None 3.38455E-05 2.23634E-05 None 0 0 1.6964E-06 1.09878E-04 0
R/H 15346 Ig-105 45 rs367996763 0.2062 -0.959 1.0 D 0.749 0.453 None gnomAD-2.1.1 2.02E-05 None None None None N None 1.94099E-04 2.91E-05 None 0 0 None 0 None 0 8.95E-06 0
R/H 15346 Ig-105 45 rs367996763 0.2062 -0.959 1.0 D 0.749 0.453 None gnomAD-3.1.2 3.29E-05 None None None None N None 9.66E-05 0 0 0 1.94932E-04 None 0 0 0 0 0
R/H 15346 Ig-105 45 rs367996763 0.2062 -0.959 1.0 D 0.749 0.453 None gnomAD-4.0.0 1.36455E-05 None None None None N None 1.06969E-04 5.0122E-05 None 0 2.23684E-05 None 0 0 7.63377E-06 1.09859E-05 0
K/E 15524 Ig-107 45 rs548285460 0.829 None 0.999 D 0.483 0.707 0.529861178392 gnomAD-4.0.0 1.20033E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
R/Q 16008 Ig-109 41 rs771224957 0.2988 -0.376 1.0 D 0.671 0.376 0.223146558224 gnomAD-2.1.1 4.85E-05 None None None None N None 0 1.45307E-04 None 0 1.68558E-04 None 0 None 0 2.69E-05 1.66389E-04
R/Q 16008 Ig-109 41 rs771224957 0.2988 -0.376 1.0 D 0.671 0.376 0.223146558224 gnomAD-3.1.2 2.63E-05 None None None None N None 4.83E-05 6.57E-05 0 0 0 None 0 0 1.47E-05 0 0
R/Q 16008 Ig-109 41 rs771224957 0.2988 -0.376 1.0 D 0.671 0.376 0.223146558224 gnomAD-4.0.0 2.4806E-05 None None None None N None 4.01112E-05 1.33592E-04 None 0 2.23724E-05 None 1.5626E-05 0 2.20495E-05 0 1.60287E-05
R/W 16008 Ig-109 41 rs374233884 0.6005 -0.518 1.0 D 0.667 0.432 0.465891899173 gnomAD-2.1.1 4.85E-05 None None None None N None 0 0 None 0 5.62E-05 None 2.61472E-04 None 4.64E-05 1.79E-05 0
R/W 16008 Ig-109 41 rs374233884 0.6005 -0.518 1.0 D 0.667 0.432 0.465891899173 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.95E-05 0 0
R/W 16008 Ig-109 41 rs374233884 0.6005 -0.518 1.0 D 0.667 0.432 0.465891899173 gnomAD-4.0.0 2.72881E-05 None None None None N None 1.33761E-05 0 None 0 2.23804E-05 None 0 0 1.61134E-05 2.52597E-04 0
R/I 16304 Ig-110 43 None 0.8662 None 1.0 D 0.717 0.434 0.567858160113 gnomAD-4.0.0 2.0542E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7998E-06 0 1.65887E-05
R/G 17000 Ig-111 46 rs1488377419 0.495 None 0.81 D 0.295 0.267 0.404453528171 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/G 17000 Ig-111 46 rs1488377419 0.495 None 0.81 D 0.295 0.267 0.404453528171 gnomAD-4.0.0 6.5799E-06 None None None None N None 2.41278E-05 0 None 0 0 None 0 0 0 0 0
R/K 17000 Ig-111 46 rs767481574 0.2365 -0.399 0.897 N 0.271 0.195 None gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 2.81025E-04 None 0 None 0 0 0
R/K 17000 Ig-111 46 rs767481574 0.2365 -0.399 0.897 N 0.271 0.195 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.95236E-04 None 0 0 0 0 0
R/K 17000 Ig-111 46 rs767481574 0.2365 -0.399 0.897 N 0.271 0.195 None gnomAD-4.0.0 5.14654E-05 None None None None N None 0 0 None 0 1.83593E-03 None 0 0 8.48001E-07 0 0
R/S 17000 Ig-111 46 None 0.7145 None 0.681 N 0.289 0.175 0.231231049324 gnomAD-4.0.0 1.5932E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86202E-06 0 0
R/T 17000 Ig-111 46 rs767481574 0.4357 -0.499 0.81 D 0.307 0.451 0.453307948783 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
R/T 17000 Ig-111 46 rs767481574 0.4357 -0.499 0.81 D 0.307 0.451 0.453307948783 gnomAD-4.0.0 2.73829E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59936E-06 0 0
R/C 17321 Ig-112 71 rs752764827 0.8719 -1.605 1.0 N 0.872 0.421 None gnomAD-2.1.1 2.15E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.7E-05 0
R/C 17321 Ig-112 71 rs752764827 0.8719 -1.605 1.0 N 0.872 0.421 None gnomAD-3.1.2 1.98E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 2.95E-05 0 0
R/C 17321 Ig-112 71 rs752764827 0.8719 -1.605 1.0 N 0.872 0.421 None gnomAD-4.0.0 3.59848E-05 None None None None N None 2.67537E-05 0 None 0 0 None 0 0 4.49589E-05 0 4.81093E-05
R/H 17321 Ig-112 71 rs530304166 0.6481 -2.067 1.0 N 0.809 0.384 None gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 1.78E-05 0
R/H 17321 Ig-112 71 rs530304166 0.6481 -2.067 1.0 N 0.809 0.384 None gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/H 17321 Ig-112 71 rs530304166 0.6481 -2.067 1.0 N 0.809 0.384 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
R/H 17321 Ig-112 71 rs530304166 0.6481 -2.067 1.0 N 0.809 0.384 None gnomAD-4.0.0 2.10923E-05 None None None None N None 0 0 None 0 2.24316E-05 None 0 0 2.71449E-05 1.09994E-05 0
R/S 17321 Ig-112 71 rs752764827 0.9837 -1.086 1.0 N 0.793 0.452 0.345405024496 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
R/S 17321 Ig-112 71 rs752764827 0.9837 -1.086 1.0 N 0.793 0.452 0.345405024496 gnomAD-4.0.0 6.84965E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00131E-07 0 0
R/C 17717 Ig-113 41 rs369001587 0.298 -0.718 1.0 N 0.604 0.371 None gnomAD-2.1.1 1.61E-05 None None None None N None 6.47E-05 0 None 0 0 None 6.54E-05 None 0 8.91E-06 0
R/C 17717 Ig-113 41 rs369001587 0.298 -0.718 1.0 N 0.604 0.371 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 17717 Ig-113 41 rs369001587 0.298 -0.718 1.0 N 0.604 0.371 None gnomAD-4.0.0 7.43944E-06 None None None None N None 0 0 None 0 0 None 4.68765E-05 0 3.39165E-06 4.39242E-05 1.60215E-05
R/H 17717 Ig-113 41 rs757018821 0.1691 -1.571 0.997 N 0.406 0.334 0.262175524916 gnomAD-2.1.1 5.72E-05 None None None None N None 2.48242E-04 1.13116E-04 None 0 0 None 1.30719E-04 None 0 1.57E-05 0
R/H 17717 Ig-113 41 rs757018821 0.1691 -1.571 0.997 N 0.406 0.334 0.262175524916 gnomAD-3.1.2 6.58E-05 None None None None N None 2.17402E-04 0 0 0 0 None 0 0 0 2.07039E-04 0
R/H 17717 Ig-113 41 rs757018821 0.1691 -1.571 0.997 N 0.406 0.334 0.262175524916 gnomAD-4.0.0 2.54175E-05 None None None None N None 2.00476E-04 5.003E-05 None 0 2.23095E-05 None 0 0 4.23954E-06 1.53725E-04 4.806E-05
R/P 17717 Ig-113 41 rs757018821 0.9573 -0.22 0.994 N 0.477 0.383 0.406120066682 gnomAD-2.1.1 7.15E-06 None None None None N None 0 0 None 0 1.02659E-04 None 0 None 0 0 0
R/P 17717 Ig-113 41 rs757018821 0.9573 -0.22 0.994 N 0.477 0.383 0.406120066682 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94704E-04 None 0 0 0 0 0
R/P 17717 Ig-113 41 rs757018821 0.9573 -0.22 0.994 N 0.477 0.383 0.406120066682 gnomAD-4.0.0 1.23988E-06 None None None None N None 0 0 None 0 4.4619E-05 None 0 0 0 0 0
A/S 18013 Ig-114 46 rs531242797 0.0741 -0.733 0.005 N 0.142 0.046 0.15556083564 gnomAD-2.1.1 1.09207E-04 None None None None N None 0 0 None 0 0 None 8.82757E-04 None 0 0 0
A/S 18013 Ig-114 46 rs531242797 0.0741 -0.733 0.005 N 0.142 0.046 0.15556083564 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 0 8.29531E-04 0
A/S 18013 Ig-114 46 rs531242797 0.0741 -0.733 0.005 N 0.142 0.046 0.15556083564 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
A/S 18013 Ig-114 46 rs531242797 0.0741 -0.733 0.005 N 0.142 0.046 0.15556083564 gnomAD-4.0.0 4.4027E-05 None None None None N None 0 0 None 0 0 None 0 0 0 7.69045E-04 1.602E-05
A/T 18013 Ig-114 46 rs531242797 0.0599 -0.701 None N 0.078 0.071 0.178374595973 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.97E-06 0
A/T 18013 Ig-114 46 rs531242797 0.0599 -0.701 None N 0.078 0.071 0.178374595973 gnomAD-4.0.0 6.84636E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9987E-07 0 0
H/Y 18737 Ig-116 50 None 0.1854 None 0.999 N 0.581 0.431 0.278968121808 gnomAD-4.0.0 1.59293E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43456E-05 0
R/C 19432 Ig-118 42 rs1345945391 0.1348 -0.037 0.022 N 0.257 0.275 0.216624796971 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 2.87853E-04 0 0
R/C 19432 Ig-118 42 rs1345945391 0.1348 -0.037 0.022 N 0.257 0.275 0.216624796971 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.43E-05 0 0 0 0
R/C 19432 Ig-118 42 rs1345945391 0.1348 -0.037 0.022 N 0.257 0.275 0.216624796971 gnomAD-4.0.0 3.71919E-06 None None None None N None 0 0 None 0 0 None 1.5626E-05 0 3.39093E-06 0 1.60169E-05
R/H 19432 Ig-118 42 rs745631866 0.0919 -1.09 0.956 N 0.259 0.308 None gnomAD-2.1.1 2.82E-05 None None None None N None 0 8.71E-05 None 0 5.61E-05 None 9.8E-05 None 0 0 0
R/H 19432 Ig-118 42 rs745631866 0.0919 -1.09 0.956 N 0.259 0.308 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 1.94099E-04 None 0 0 1.47E-05 0 4.78927E-04
R/H 19432 Ig-118 42 rs745631866 0.0919 -1.09 0.956 N 0.259 0.308 None gnomAD-4.0.0 1.48771E-05 None None None None N None 1.33604E-05 8.34251E-05 None 0 1.11772E-04 None 0 0 5.08644E-06 4.39203E-05 4.80492E-05
R/I 19832 Ig-119 43 rs1405596883 0.117 None 0.029 N 0.493 0.141 0.365509141856 gnomAD-4.0.0 3.18366E-06 None None None None N None 0 0 None 0 0 None 1.88253E-05 0 2.8594E-06 0 0
R/K 19832 Ig-119 43 rs1405596883 0.075 -0.781 0.005 N 0.16 0.085 0.112648838833 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
R/K 19832 Ig-119 43 rs1405596883 0.075 -0.781 0.005 N 0.16 0.085 0.112648838833 gnomAD-4.0.0 1.59183E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8594E-06 0 0
R/K 20522 Ig-121 44 rs1204056923 0.2767 None 0.863 N 0.381 0.198 0.27479166964 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/K 20522 Ig-121 44 rs1204056923 0.2767 None 0.863 N 0.381 0.198 0.27479166964 gnomAD-4.0.0 5.07532E-06 None None None None N None 0 0 None 0 0 None 0 0 6.02495E-06 0 0
R/S 20522 Ig-121 44 rs576946726 0.8211 -0.999 0.939 N 0.398 0.319 0.151104730317 gnomAD-2.1.1 1.43E-05 None None None None N None 0 0 None 0 2.05994E-04 None 0 None 0 0 0
R/S 20522 Ig-121 44 rs576946726 0.8211 -0.999 0.939 N 0.398 0.319 0.151104730317 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94175E-04 None 0 0 0 0 0
R/S 20522 Ig-121 44 rs576946726 0.8211 -0.999 0.939 N 0.398 0.319 0.151104730317 gnomAD-4.0.0 2.48004E-06 None None None None N None 0 0 None 0 8.93416E-05 None 0 0 0 0 0
R/K 20817 Ig-122 49 None 0.3518 None 0.997 N 0.537 0.401 0.387850303812 gnomAD-4.0.0 1.59198E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43312E-05 0
R/S 20817 Ig-122 49 rs372984487 0.8625 None 1.0 N 0.725 0.346 0.241078983079 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/S 20817 Ig-122 49 rs372984487 0.8625 None 1.0 N 0.725 0.346 0.241078983079 gnomAD-4.0.0 6.8434E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99572E-07 0 0
R/W 20817 Ig-122 49 None 0.4618 None 1.0 D 0.721 0.613 0.603771522108 gnomAD-4.0.0 4.79027E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29689E-06 0 0
H/L 21512 Ig-124 44 rs774754081 0.2311 0.435 0.081 N 0.331 0.151 None gnomAD-2.1.1 1.79E-05 None None None None N None 2.06868E-04 0 None 0 0 None 0 None 0 0 0
H/L 21512 Ig-124 44 rs774754081 0.2311 0.435 0.081 N 0.331 0.151 None gnomAD-3.1.2 6.57E-05 None None None None N None 2.41255E-04 0 0 0 0 None 0 0 0 0 0
H/L 21512 Ig-124 44 rs774754081 0.2311 0.435 0.081 N 0.331 0.151 None gnomAD-4.0.0 1.17773E-05 None None None None N None 2.00272E-04 0 None 0 0 None 0 0 3.39128E-06 0 0
G/C 21909 Ig-125 44 rs878898044 0.3163 -0.352 0.98 N 0.638 0.425 None gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
G/C 21909 Ig-125 44 rs878898044 0.3163 -0.352 0.98 N 0.638 0.425 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/C 21909 Ig-125 44 rs878898044 0.3163 -0.352 0.98 N 0.638 0.425 None gnomAD-4.0.0 1.86184E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54546E-06 0 0
R/G 22596 Ig-127 37 rs761026013 0.8057 -0.818 1.0 N 0.659 0.525 0.471620082127 gnomAD-2.1.1 8.04E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.89E-06 0
R/G 22596 Ig-127 37 rs761026013 0.8057 -0.818 1.0 N 0.659 0.525 0.471620082127 gnomAD-4.0.0 4.7905E-06 None None None None N None 0 2.23634E-05 None 0 0 None 0 0 5.39788E-06 0 0
R/T 22596 Ig-127 37 rs1197078573 0.8158 -0.227 1.0 N 0.703 0.479 0.482500522706 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
R/T 22596 Ig-127 37 rs1197078573 0.8158 -0.227 1.0 N 0.703 0.479 0.482500522706 gnomAD-4.0.0 3.18399E-06 None None None None N None 0 4.57352E-05 None 0 0 None 0 0 0 0 0
I/T 22993 Ig-128 44 rs2046666627 0.1241 None 0.001 N 0.195 0.058 0.407767136052 gnomAD-3.1.2 6.6E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.08681E-04 0
I/T 22993 Ig-128 44 rs2046666627 0.1241 None 0.001 N 0.195 0.058 0.407767136052 gnomAD-4.0.0 6.5977E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.08681E-04 0
I/V 22993 Ig-128 44 rs752579029 0.0715 -0.796 0.001 N 0.109 0.047 0.339555952218 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/V 22993 Ig-128 44 rs752579029 0.0715 -0.796 0.001 N 0.109 0.047 0.339555952218 gnomAD-4.0.0 1.59204E-06 None None None None N None 0 2.28697E-05 None 0 0 None 0 0 0 0 0
R/K 23679 Ig-130 43 rs200144345 0.3616 -0.723 0.997 N 0.466 0.224 None gnomAD-2.1.1 5.22477E-04 None None None None N None 4.14E-05 2.84E-05 None 3.00388E-03 0 None 6.87308E-04 None 4.01E-05 6.73E-04 7.05617E-04
R/K 23679 Ig-130 43 rs200144345 0.3616 -0.723 0.997 N 0.466 0.224 None gnomAD-3.1.2 4.07686E-04 None None None None N None 7.24E-05 3.92927E-04 0 2.59366E-03 0 None 0 3.16456E-03 5.73648E-04 6.21633E-04 4.78469E-04
R/K 23679 Ig-130 43 rs200144345 0.3616 -0.723 0.997 N 0.466 0.224 None gnomAD-4.0.0 5.92587E-04 None None None None N None 6.66542E-05 1.33369E-04 None 2.83937E-03 0 None 6.25215E-05 1.32144E-03 6.26505E-04 6.91897E-04 7.206E-04
R/T 24761 Ig-133 46 rs1708301817 0.9257 None 1.0 N 0.694 0.463 0.622825188919 gnomAD-4.0.0 2.0529E-06 None None None None N None 0 0 None 3.82819E-05 0 None 0 0 1.79916E-06 0 0
R/L 25157 Ig-134 47 None 0.3406 None 0.722 N 0.433 0.305 0.405700215632 gnomAD-4.0.0 6.84339E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99588E-07 0 0
R/Q 25157 Ig-134 47 rs779410073 0.161 -0.079 0.742 N 0.454 0.249 0.107399877778 gnomAD-2.1.1 2.41E-05 None None None None N None 0 0 None 0 0 None 0 None 0 5.33E-05 0
R/Q 25157 Ig-134 47 rs779410073 0.161 -0.079 0.742 N 0.454 0.249 0.107399877778 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/Q 25157 Ig-134 47 rs779410073 0.161 -0.079 0.742 N 0.454 0.249 0.107399877778 gnomAD-4.0.0 8.67763E-06 None None None None N None 1.33536E-05 0 None 0 0 None 0 0 1.10206E-05 0 0
R/G 25843 Ig-136 46 rs773999364 0.8917 -1.579 0.892 N 0.475 0.252 None gnomAD-2.1.1 4.04E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
R/G 25843 Ig-136 46 rs773999364 0.8917 -1.579 0.892 N 0.475 0.252 None gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/G 25843 Ig-136 46 rs773999364 0.8917 -1.579 0.892 N 0.475 0.252 None gnomAD-4.0.0 2.47933E-06 None None None None N None 4.00598E-05 0 None 0 0 None 0 0 8.47777E-07 0 0
R/K 25843 Ig-136 46 rs1706876007 0.4733 None 0.025 N 0.203 0.255 0.26169431596 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/K 25843 Ig-136 46 rs1706876007 0.4733 None 0.025 N 0.203 0.255 0.26169431596 gnomAD-4.0.0 1.85959E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54336E-06 0 0
R/S 25843 Ig-136 46 rs2154167135 0.9447 None 0.892 N 0.483 0.256 0.332133492242 gnomAD-4.0.0 1.59196E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4332E-05 0
R/T 25843 Ig-136 46 None 0.8984 None 0.967 N 0.478 0.434 0.426436156839 gnomAD-4.0.0 1.16339E-05 None None None None N None 0 0 None 0 0 None 0 0 1.52936E-05 0 0
R/G 26925 Ig-139 46 rs373948797 0.9421 -1.139 0.892 N 0.391 0.347 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
R/G 26925 Ig-139 46 rs373948797 0.9421 -1.139 0.892 N 0.391 0.347 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/G 26925 Ig-139 46 rs373948797 0.9421 -1.139 0.892 N 0.391 0.347 None gnomAD-4.0.0 6.5735E-06 None None None None N None 2.41231E-05 0 None 0 0 None 0 0 0 0 0
R/K 26925 Ig-139 46 rs748215561 0.5417 -0.448 0.773 N 0.47 0.255 0.202949470691 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.45E-05 0
R/K 26925 Ig-139 46 rs748215561 0.5417 -0.448 0.773 N 0.47 0.255 0.202949470691 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/K 26925 Ig-139 46 rs748215561 0.5417 -0.448 0.773 N 0.47 0.255 0.202949470691 gnomAD-4.0.0 1.79736E-05 None None None None N None 0 0 None 0 0 None 0 0 2.45831E-05 0 0
R/K 28008 Ig-142 46 None 0.3955 None 0.997 N 0.461 0.372 0.239305524855 gnomAD-4.0.0 1.59261E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85982E-06 0 0
R/T 28403 Ig-143 46 rs750869245 0.2732 -0.656 0.001 N 0.264 0.236 0.42324137094 gnomAD-2.1.1 2.41E-05 None None None None N None 0 1.74004E-04 None 0 0 None 0 None 0 0 0
R/T 28403 Ig-143 46 rs750869245 0.2732 -0.656 0.001 N 0.264 0.236 0.42324137094 gnomAD-4.0.0 1.1139E-05 None None None None N None 0 1.60066E-04 None 0 0 None 0 0 0 0 0
R/K 29090 Ig-145 46 None 0.5 None 0.997 N 0.473 0.283 0.379881503574 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
R/S 29090 Ig-145 46 rs1335648809 0.9426 None 1.0 N 0.737 0.428 0.308278614506 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
R/S 29090 Ig-145 46 rs1335648809 0.9426 None 1.0 N 0.737 0.428 0.308278614506 gnomAD-4.0.0 1.36833E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79886E-06 0 0
L/M 29486 Ig-146 43 None 0.0893 None 0.984 N 0.481 0.176 0.452264262256 gnomAD-4.0.0 1.59158E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85829E-06 0 0
L/P 29486 Ig-146 43 rs1376620284 0.4612 -0.731 0.984 N 0.595 0.268 0.628357094819 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66279E-04
L/P 29486 Ig-146 43 rs1376620284 0.4612 -0.731 0.984 N 0.595 0.268 0.628357094819 gnomAD-4.0.0 1.59156E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02517E-05
R/G 29885 Ig-147 44 rs368173790 0.4257 -1.712 0.645 N 0.497 0.267 0.350964488264 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
R/G 29885 Ig-147 44 rs368173790 0.4257 -1.712 0.645 N 0.497 0.267 0.350964488264 gnomAD-4.0.0 1.59301E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85798E-06 0 0
F/C 30177 Ig-148 46 rs772875882 0.0794 -0.168 0.258 N 0.353 0.051 0.195762928549 gnomAD-2.1.1 4.28E-06 None None None None N None 0 0 None 0 5.67E-05 None 0 None 0 0 0
F/C 30177 Ig-148 46 rs772875882 0.0794 -0.168 0.258 N 0.353 0.051 0.195762928549 gnomAD-4.0.0 8.2216E-06 None None None None N None 0 0 None 0 1.39821E-04 None 0 0 0 0 0
F/L 30177 Ig-148 46 rs748918212 0.3195 -0.646 None N 0.093 0.048 0.126345400529 gnomAD-2.1.1 1.28E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.8E-05 0
F/L 30177 Ig-148 46 rs748918212 0.3195 -0.646 None N 0.093 0.048 0.126345400529 gnomAD-4.0.0 5.55105E-06 None None None None N None 0 0 None 0 7.61615E-05 None 3.80243E-05 0 2.72532E-06 0 0
R/Q 31261 Ig-151 44 rs755974993 0.3105 -0.4 1.0 N 0.667 0.371 0.246773566709 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/Q 31261 Ig-151 44 rs755974993 0.3105 -0.4 1.0 N 0.667 0.371 0.246773566709 gnomAD-4.0.0 4.78932E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39657E-06 1.15934E-05 0
K/E 31661 Ig-152 41 rs1268995899 0.5798 0.295 0.999 N 0.566 0.372 0.215869574891 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/E 31661 Ig-152 41 rs1268995899 0.5798 0.295 0.999 N 0.566 0.372 0.215869574891 gnomAD-4.0.0 1.36841E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99476E-07 1.15934E-05 0
K/N 31661 Ig-152 41 None 0.6502 None 1.0 N 0.657 0.253 0.137902524267 gnomAD-4.0.0 6.84208E-07 None None None None N None 0 0 None 3.82673E-05 0 None 0 0 0 0 0
R/Q 32058 Ig-153 42 rs374063064 0.2908 -0.08 1.0 N 0.733 0.331 None gnomAD-2.1.1 8.92E-05 None None None None I None 1.24008E-04 2.83E-05 None 0 0 None 0 None 0 1.5605E-04 1.40252E-04
R/Q 32058 Ig-153 42 rs374063064 0.2908 -0.08 1.0 N 0.733 0.331 None gnomAD-3.1.2 1.31539E-04 None None None None I None 1.20744E-04 1.31165E-04 0 0 0 None 0 0 1.91165E-04 0 0
R/Q 32058 Ig-153 42 rs374063064 0.2908 -0.08 1.0 N 0.733 0.331 None gnomAD-4.0.0 1.71673E-04 None None None None I None 1.46925E-04 6.67E-05 None 3.37838E-05 6.68628E-05 None 0 0 2.09372E-04 1.09806E-05 1.60149E-04
R/W 32058 Ig-153 42 rs201463708 0.5913 -0.628 1.0 D 0.731 0.442 None gnomAD-2.1.1 3.21E-05 None None None None I None 1.6533E-04 0 None 0 0 None 0 None 0 3.12E-05 1.40252E-04
R/W 32058 Ig-153 42 rs201463708 0.5913 -0.628 1.0 D 0.731 0.442 None gnomAD-3.1.2 7.24E-05 None None None None I None 1.93424E-04 0 0 0 0 None 0 0 4.41E-05 0 0
R/W 32058 Ig-153 42 rs201463708 0.5913 -0.628 1.0 D 0.731 0.442 None gnomAD-4.0.0 2.23124E-05 None None None None I None 1.4702E-04 0 None 0 0 None 3.12471E-05 0 1.61057E-05 0 6.40553E-05
R/C 32352 Ig-154 46 rs753874904 0.6432 -1.143 1.0 N 0.749 0.474 0.69617267371 gnomAD-2.1.1 3.63E-05 None None None None N None 0 2.60854E-04 None 0 0 None 0 None 0 0 0
R/C 32352 Ig-154 46 rs753874904 0.6432 -1.143 1.0 N 0.749 0.474 0.69617267371 gnomAD-3.1.2 1.31E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
R/C 32352 Ig-154 46 rs753874904 0.6432 -1.143 1.0 N 0.749 0.474 0.69617267371 gnomAD-4.0.0 2.16904E-05 None None None None N None 0 2.33396E-04 None 0 0 None 0 0 1.69524E-05 1.09789E-05 0
R/G 32352 Ig-154 46 rs753874904 0.6262 -1.653 1.0 N 0.679 0.441 0.588775385127 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
R/G 32352 Ig-154 46 rs753874904 0.6262 -1.653 1.0 N 0.679 0.441 0.588775385127 gnomAD-4.0.0 1.36843E-06 None None None None N None 0 0 None 0 5.03829E-05 None 0 0 0 0 0
R/H 32352 Ig-154 46 rs575939045 0.2573 -1.619 1.0 N 0.751 0.37 None gnomAD-2.1.1 7.51E-05 None None None None N None 0 1.13173E-04 None 0 0 None 3.27E-05 None 0 1.09878E-04 2.81057E-04
R/H 32352 Ig-154 46 rs575939045 0.2573 -1.619 1.0 N 0.751 0.37 None gnomAD-3.1.2 1.1177E-04 None None None None N None 4.83E-05 6.55E-05 0 0 0 None 0 0 2.05852E-04 0 0
R/H 32352 Ig-154 46 rs575939045 0.2573 -1.619 1.0 N 0.751 0.37 None 1000 genomes 3.99361E-04 None None None None N None 0 1.4E-03 None None 0 1E-03 None None None 0 None
R/H 32352 Ig-154 46 rs575939045 0.2573 -1.619 1.0 N 0.751 0.37 None gnomAD-4.0.0 1.50579E-04 None None None None N None 2.6666E-05 4.99983E-05 None 0 0 None 1.5624E-05 0 1.95802E-04 1.09794E-05 8.0023E-05
R/L 32352 Ig-154 46 rs575939045 0.6151 None 1.0 N 0.679 0.423 0.575080649919 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
R/L 32352 Ig-154 46 rs575939045 0.6151 None 1.0 N 0.679 0.423 0.575080649919 gnomAD-4.0.0 6.57471E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07039E-04 0
R/S 32352 Ig-154 46 None 0.8525 None 1.0 N 0.707 0.418 0.385906861911 gnomAD-4.0.0 6.84216E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65656E-05
R/C 32748 Ig-155 41 rs72648272 0.3663 -0.058 1.0 N 0.717 0.354 None gnomAD-2.1.1 3.97485E-03 None None None None N None 2.47995E-04 5.09338E-04 None 1.16032E-03 0 None 2.74492E-03 None 8.83505E-03 5.86876E-03 2.94448E-03
R/C 32748 Ig-155 41 rs72648272 0.3663 -0.058 1.0 N 0.717 0.354 None gnomAD-3.1.2 3.6019E-03 None None None None N None 5.06806E-04 1.17894E-03 1.09649E-03 1.15274E-03 0 None 1.05581E-02 0 5.55637E-03 2.69821E-03 4.78011E-04
R/C 32748 Ig-155 41 rs72648272 0.3663 -0.058 1.0 N 0.717 0.354 None 1000 genomes 1.39776E-03 None None None None N None 8E-04 0 None None 0 2E-03 None None None 4.1E-03 None
R/C 32748 Ig-155 41 rs72648272 0.3663 -0.058 1.0 N 0.717 0.354 None gnomAD-4.0.0 3.45949E-03 None None None None N None 4.26496E-04 7.66616E-04 None 8.78319E-04 2.22856E-05 None 8.96791E-03 1.65017E-03 3.82105E-03 2.22901E-03 2.91284E-03
R/H 32748 Ig-155 41 rs397517775 0.1694 -0.632 1.0 N 0.706 0.338 None gnomAD-2.1.1 6.42E-05 None None None None N None 8.26E-05 0 None 0 1.53815E-04 None 3.27E-05 None 0 9.36E-05 0
R/H 32748 Ig-155 41 rs397517775 0.1694 -0.632 1.0 N 0.706 0.338 None gnomAD-3.1.2 7.23E-05 None None None None N None 4.83E-05 0 0 0 1.92827E-04 None 0 0 1.02896E-04 2.07125E-04 0
R/H 32748 Ig-155 41 rs397517775 0.1694 -0.632 1.0 N 0.706 0.338 None gnomAD-4.0.0 6.19649E-05 None None None None N None 3.99883E-05 0 None 0 6.68628E-05 None 0 0 7.45902E-05 3.29374E-05 4.80169E-05
H/Q 33641 Ig-159 46 rs1691127745 0.224 None 0.042 N 0.131 0.132 0.107399877778 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/R 33641 Ig-159 46 rs759457802 0.1774 -0.984 0.608 N 0.244 0.202 0.0954503805726 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.66908E-04 None 0 None 0 0 0
H/R 33641 Ig-159 46 rs759457802 0.1774 -0.984 0.608 N 0.244 0.202 0.0954503805726 gnomAD-4.0.0 3.18251E-06 None None None None N None 0 0 None 0 5.54508E-05 None 0 0 0 0 0
H/Y 33641 Ig-159 46 rs1357251504 0.1491 0.759 0.024 N 0.109 0.145 0.167679373172 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
H/Y 33641 Ig-159 46 rs1357251504 0.1491 0.759 0.024 N 0.109 0.145 0.167679373172 gnomAD-4.0.0 1.59131E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
K/T 34182 Ig-160 46 rs1348175807 0.6517 -0.736 1.0 N 0.695 0.48 0.326074293725 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
K/T 34182 Ig-160 46 rs1348175807 0.6517 -0.736 1.0 N 0.695 0.48 0.326074293725 gnomAD-4.0.0 4.77303E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57319E-06 0 0
N/D 34408 Ig-162 46 None 0.1928 None 0.024 N 0.268 0.153 0.202086224978 gnomAD-4.0.0 1.59158E-06 None None None None I None 0 0 None 0 0 None 1.891E-05 0 0 0 0
N/I 34408 Ig-162 46 None 0.5203 None 0.171 N 0.411 0.197 0.430579932962 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
N/K 34408 Ig-162 46 None 0.3128 None None N 0.124 0.097 0.137902524267 gnomAD-4.0.0 1.59182E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85773E-06 0 0
R/C 35174 Ig-164 46 rs778207634 0.1466 -0.859 0.997 D 0.583 0.52 0.720114801303 gnomAD-2.1.1 4.82E-05 None None None None N None 0 2.9E-05 None 0 5.00779E-04 None 3.27E-05 None 0 8.86E-06 0
R/C 35174 Ig-164 46 rs778207634 0.1466 -0.859 0.997 D 0.583 0.52 0.720114801303 gnomAD-3.1.2 4.6E-05 None None None None N None 0 0 0 0 1.15473E-03 None 0 0 1.47E-05 0 0
R/C 35174 Ig-164 46 rs778207634 0.1466 -0.859 0.997 D 0.583 0.52 0.720114801303 gnomAD-4.0.0 4.70925E-05 None None None None N None 0 1.6665E-05 None 0 1.31415E-03 None 0 1.64366E-04 8.4754E-06 5.48932E-05 0
R/H 35174 Ig-164 46 rs756575734 0.0913 -1.479 0.028 N 0.229 0.154 None gnomAD-2.1.1 2.85E-05 None None None None N None 4.13E-05 2.83E-05 None 0 0 None 0 None 0 4.67E-05 0
R/H 35174 Ig-164 46 rs756575734 0.0913 -1.479 0.028 N 0.229 0.154 None gnomAD-3.1.2 5.26E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 7.35E-05 2.07641E-04 0
R/H 35174 Ig-164 46 rs756575734 0.0913 -1.479 0.028 N 0.229 0.154 None gnomAD-4.0.0 7.3738E-05 None None None None N None 6.67575E-05 0 None 0 0 None 0 0 8.64489E-05 1.09801E-05 1.76113E-04
H/N 35331 Ig-165 46 rs753993485 0.2381 -0.579 0.99 N 0.427 0.446 0.363158594168 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
H/N 35331 Ig-165 46 rs753993485 0.2381 -0.579 0.99 N 0.427 0.446 0.363158594168 gnomAD-4.0.0 1.59091E-06 None None None None N None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
H/Y 35331 Ig-165 46 None 0.211 None 0.997 D 0.442 0.404 0.40417439687 gnomAD-4.0.0 1.59091E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
K/T 35465 Ig-166 46 rs1408549737 0.235 None 0.999 N 0.713 0.369 0.272639205421 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/T 35465 Ig-166 46 rs1408549737 0.235 None 0.999 N 0.713 0.369 0.272639205421 gnomAD-4.0.0 2.59457E-06 None None None None N None 0 0 None 0 0 None 0 0 4.81299E-06 0 0
N/D 35747 Ig-168 46 None 0.135 None 0.117 N 0.358 0.094 0.0482279557977 gnomAD-4.0.0 1.59264E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85883E-06 0 0
N/H 35747 Ig-168 46 None 0.1074 None None N 0.143 0.098 0.0401082797425 gnomAD-4.0.0 1.59264E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85883E-06 0 0
N/S 35747 Ig-168 46 rs903505453 0.0758 None 0.027 N 0.355 0.181 0.0762999501168 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
N/S 35747 Ig-168 46 rs903505453 0.0758 None 0.027 N 0.355 0.181 0.0762999501168 gnomAD-4.0.0 3.09948E-06 None None None None N None 1.33511E-05 0 None 0 0 None 0 0 3.39064E-06 0 0
N/Y 35747 Ig-168 46 rs1687478590 0.2055 None 0.188 N 0.363 0.054 0.234412748748 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
N/Y 35747 Ig-168 46 rs1687478590 0.2055 None 0.188 N 0.363 0.054 0.234412748748 gnomAD-4.0.0 6.57039E-06 None None None None N None 2.41173E-05 0 None 0 0 None 0 0 0 0 0
R/K 35944 Ig-169 48 None 0.3309 None 0.997 N 0.448 0.372 0.231231049324 gnomAD-4.0.0 1.20032E-06 None None None -0.358(OBSL1) -0.122(OBSCN) N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.