Structural position:

  • Domain Type: Ig
  • Aligned Position: 122
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand D

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
Q/H 55 Ig-1 50 rs1561527314 0.2926 None 0.995 N 0.586 0.49 0.400468435593 gnomAD-4.0.0 2.40064E-06 None None None 0.073(TCAP) N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
Q/R 55 Ig-1 50 None 0.1502 None 0.868 N 0.555 0.502 0.190952846119 gnomAD-4.0.0 1.5905E-06 None None None -0.47(TCAP) N None 0 0 None 0 0 None 0 0 2.85649E-06 0 0
Q/H 151 Ig-2 48 rs975437384 0.5801 None 0.981 N 0.345 0.245 0.277317399466 gnomAD-3.1.2 6.57E-06 None None None 0.477(TCAP) N None 0 0 1.09649E-03 0 0 None 0 0 0 0 0
Q/H 151 Ig-2 48 rs975437384 0.5801 None 0.981 N 0.345 0.245 0.277317399466 gnomAD-4.0.0 6.57056E-06 None None None 0.477(TCAP) N None 0 0 None 0 0 None 0 0 0 0 0
K/N 1129 Ig-4 48 rs765840063 0.8388 0.133 0.997 N 0.609 0.374 0.324161360171 gnomAD-2.1.1 3.98E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/N 1129 Ig-4 48 rs765840063 0.8388 0.133 0.997 N 0.609 0.374 0.324161360171 gnomAD-4.0.0 3.18216E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.86549E-05 0
K/R 1129 Ig-4 48 rs181375012 0.1167 0.109 0.121 N 0.213 0.279 None gnomAD-2.1.1 2.48E-05 None None None None I None 0 0 None 0 3.52077E-04 None 0 None 0 0 0
K/R 1129 Ig-4 48 rs181375012 0.1167 0.109 0.121 N 0.213 0.279 None gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 7.6864E-04 None 0 0 0 0 0
K/R 1129 Ig-4 48 rs181375012 0.1167 0.109 0.121 N 0.213 0.279 None 1000 genomes 3.99361E-04 None None None None I None 0 0 None None 2E-03 0 None None None 0 None
K/R 1129 Ig-4 48 rs181375012 0.1167 0.109 0.121 N 0.213 0.279 None gnomAD-4.0.0 5.45235E-05 None None None None I None 0 0 None 0 1.94058E-03 None 0 0 0 0 1.60005E-05
R/G 1605 Ig-7 50 None 0.3005 None 0.324 N 0.507 0.29 0.490839437361 gnomAD-4.0.0 6.8411E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99332E-07 0 0
R/C 1752 Ig-8 50 rs1259833413 0.4258 -0.595 1.0 D 0.731 0.619 0.79222543356 gnomAD-2.1.1 7.98E-06 None None None None I None 0 2.89E-05 None 0 0 None 0 None 0 8.83E-06 0
R/C 1752 Ig-8 50 rs1259833413 0.4258 -0.595 1.0 D 0.731 0.619 0.79222543356 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 1752 Ig-8 50 rs1259833413 0.4258 -0.595 1.0 D 0.731 0.619 0.79222543356 gnomAD-4.0.0 5.57664E-06 None None None None I None 1.33501E-05 1.66722E-05 None 0 0 None 0 0 4.23732E-06 1.09794E-05 1.60041E-05
R/H 1752 Ig-8 50 rs150737838 0.181 -1.262 1.0 N 0.734 0.521 None gnomAD-2.1.1 1.63017E-04 None None None None I None 0 1.04543E-03 None 1.93237E-04 1.00543E-04 None 6.53E-05 None 0 2.33E-05 0
R/H 1752 Ig-8 50 rs150737838 0.181 -1.262 1.0 N 0.734 0.521 None gnomAD-3.1.2 5.26E-05 None None None None I None 0 2.61849E-04 0 0 1.92382E-04 None 0 0 2.94E-05 2.07039E-04 0
R/H 1752 Ig-8 50 rs150737838 0.181 -1.262 1.0 N 0.734 0.521 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
R/H 1752 Ig-8 50 rs150737838 0.181 -1.262 1.0 N 0.734 0.521 None gnomAD-4.0.0 4.46082E-05 None None None None I None 1.33252E-05 7.83229E-04 None 3.37769E-05 2.22946E-05 None 3.12656E-05 3.29924E-04 1.01695E-05 6.58733E-05 0
Y/F 2125 Ig-10 48 rs922207759 0.1143 None 0.999 D 0.501 0.393 0.534719010399 gnomAD-4.0.0 1.59073E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
Y/H 2125 Ig-10 48 rs2092122812 0.3969 None 1.0 N 0.632 0.481 0.562692193803 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.42E-05 0 0 0 0
Y/H 2125 Ig-10 48 rs2092122812 0.3969 None 1.0 N 0.632 0.481 0.562692193803 gnomAD-4.0.0 2.56139E-06 None None None None N None 0 0 None 0 0 None 3.13765E-05 0 0 0 0
R/K 2221 Ig-11 48 None 0.2146 None 0.656 N 0.521 0.185 0.28722502521 gnomAD-4.0.0 1.5908E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85683E-06 0 0
T/A 2313 Ig-12 47 rs1399835400 0.0703 None 0.005 N 0.214 0.056 0.0762999501168 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
T/I 2313 Ig-12 47 None 0.0896 None None N 0.111 0.161 0.370240404367 gnomAD-4.0.0 1.36817E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99318E-07 1.15934E-05 0
T/R 2313 Ig-12 47 rs794729579 0.179 -0.268 0.055 N 0.429 0.143 0.506972231042 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
T/R 2313 Ig-12 47 rs794729579 0.179 -0.268 0.055 N 0.429 0.143 0.506972231042 gnomAD-4.0.0 2.73633E-06 None None None None N None 0 6.70901E-05 None 0 0 None 0 0 8.99318E-07 0 0
H/L 2402 Ig-13 47 rs776956593 0.4831 0.157 1.0 N 0.741 0.366 0.668071495749 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
H/L 2402 Ig-13 47 rs776956593 0.4831 0.157 1.0 N 0.741 0.366 0.668071495749 gnomAD-4.0.0 1.59055E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
Q/P 2492 Ig-14 48 None 0.6483 None 0.484 D 0.414 0.48 0.452546404249 gnomAD-4.0.0 1.59067E-06 None None None None N None 5.65355E-05 0 None 0 0 None 0 0 0 0 0
K/E 2579 Ig-15 47 None 0.2768 None 0.41 N 0.382 0.325 0.26547132957 gnomAD-4.0.0 2.05255E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7987E-06 1.15964E-05 0
K/R 2579 Ig-15 47 rs1222416655 0.0929 -0.502 0.581 N 0.423 0.303 0.376745185316 gnomAD-2.1.1 4E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/R 2579 Ig-15 47 rs1222416655 0.0929 -0.502 0.581 N 0.423 0.303 0.376745185316 gnomAD-4.0.0 1.36836E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.15961E-05 1.65629E-05
R/G 2666 Ig-16 46 rs2091455237 0.1849 None None N 0.203 0.171 0.408988072059 gnomAD-4.0.0 2.73634E-06 None None None None N None 0 0 None 0 0 None 0 0 3.5972E-06 0 0
A/G 2754 Ig-17 48 rs770875496 0.1186 -1.046 0.006 N 0.318 0.114 0.265929055128 gnomAD-2.1.1 2.79E-05 None None None None N None 0 1.73541E-04 None 0 0 None 0 None 0 0 1.63132E-04
A/G 2754 Ig-17 48 rs770875496 0.1186 -1.046 0.006 N 0.318 0.114 0.265929055128 gnomAD-4.0.0 7.52474E-06 None None None None N None 0 1.78891E-04 None 0 0 None 0 0 0 0 4.96738E-05
R/K 2841 Ig-18 47 rs779603870 0.1292 -0.824 0.002 N 0.112 0.198 0.210429274316 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
R/K 2841 Ig-18 47 rs779603870 0.1292 -0.824 0.002 N 0.112 0.198 0.210429274316 gnomAD-4.0.0 1.36812E-06 None None None None N None 0 2.23604E-05 None 0 0 None 0 0 8.99292E-07 0 0
K/Q 2928 Ig-19 47 None 0.2993 None 0.961 N 0.508 0.382 0.238705975628 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
K/R 2928 Ig-19 47 None 0.1166 None 0.031 N 0.168 0.326 0.240491677333 gnomAD-4.0.0 1.59046E-06 None None None None N None 0 0 None 0 2.77239E-05 None 0 0 0 0 0
K/E 3104 Ig-21 47 rs2154341451 0.4139 None 0.042 N 0.313 0.269 0.29385284311 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/E 3195 Ig-22 49 None 0.1125 None None N 0.133 0.142 0.220303561663 gnomAD-4.0.0 1.59055E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85656E-06 0 0
K/I 3286 Ig-23 48 rs200052398 0.9427 0.568 1.0 N 0.797 0.609 0.726026596334 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
K/I 3286 Ig-23 48 rs200052398 0.9427 0.568 1.0 N 0.797 0.609 0.726026596334 gnomAD-4.0.0 6.84073E-07 None None None None N None 0 2.23634E-05 None 0 0 None 0 0 0 0 0
K/N 3286 Ig-23 48 rs2090032788 0.9734 None 1.0 N 0.686 0.37 0.243972157842 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07297E-04 0
K/N 3286 Ig-23 48 rs2090032788 0.9734 None 1.0 N 0.686 0.37 0.243972157842 gnomAD-4.0.0 2.56155E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.68025E-05 0
K/R 3286 Ig-23 48 rs200052398 0.1841 -0.565 0.999 N 0.523 0.332 None gnomAD-2.1.1 9.91E-05 None None None None N None 1.60218E-04 0 None 0 0 None 3.27E-05 None 0 1.7081E-04 1.38581E-04
K/R 3286 Ig-23 48 rs200052398 0.1841 -0.565 0.999 N 0.523 0.332 None gnomAD-3.1.2 1.64391E-04 None None None None N None 7.25E-05 0 0 0 0 None 0 0 3.08724E-04 0 4.77555E-04
K/R 3286 Ig-23 48 rs200052398 0.1841 -0.565 0.999 N 0.523 0.332 None 1000 genomes 3.99361E-04 None None None None N None 8E-04 0 None None 0 1E-03 None None None 0 None
K/R 3286 Ig-23 48 rs200052398 0.1841 -0.565 0.999 N 0.523 0.332 None gnomAD-4.0.0 2.40393E-04 None None None None N None 1.06672E-04 1.66639E-05 None 0 0 None 0 0 3.12715E-04 1.09808E-05 1.43982E-04
K/T 3286 Ig-23 48 None 0.8509 -1.076 1.0 N 0.718 0.558 0.549504238362 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 4.62E-05 0 0
K/T 3286 Ig-23 48 None 0.8509 -1.076 1.0 N 0.718 0.558 0.549504238362 gnomAD-4.0.0 4.78851E-06 None None None None N None 0 2.23634E-05 None 0 0 None 1.87196E-05 0 4.4965E-06 0 0
V/A 3512 Ig-25 48 rs200918396 0.3744 -1.87 None None None 0.209 None gnomAD-2.1.1 4.64E-05 None None None None I None 5.37234E-04 0 None 0 0 None 0 None 0 0 0
V/A 3512 Ig-25 48 rs200918396 0.3744 -1.87 None None None 0.209 None gnomAD-3.1.2 1.05193E-04 None None None None I None 3.86231E-04 0 0 0 0 None 0 0 0 0 0
V/A 3512 Ig-25 48 rs200918396 0.3744 -1.87 None None None 0.209 None gnomAD-4.0.0 1.61122E-05 None None None None I None 3.33769E-04 0 None 0 0 None 0 0 0 0 1.60108E-05
V/I 3512 Ig-25 48 rs748663632 0.0968 -0.811 None None None 0.14 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.65453E-04
V/I 3512 Ig-25 48 rs748663632 0.0968 -0.811 None None None 0.14 None gnomAD-4.0.0 3.18228E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43275E-05 3.02371E-05
K/R 3707 Ig-26 48 None 0.0806 None None None None 0.11 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/R 3867 Ig-27 48 rs769510047 0.1218 -0.191 0.071 N 0.162 0.137 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
K/R 3867 Ig-27 48 rs769510047 0.1218 -0.191 0.071 N 0.162 0.137 None gnomAD-4.0.0 3.18239E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71628E-06 0 0
T/I 3985 Ig-28 48 None 0.6483 None 0.051 N 0.267 0.155 None gnomAD-4.0.0 1.59118E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85786E-06 0 0
K/E 4651 Ig-29 46 rs1244637034 0.1581 0.161 0.454 N 0.332 0.198 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
K/E 4651 Ig-29 46 rs1244637034 0.1581 0.161 0.454 N 0.332 0.198 None gnomAD-4.0.0 3.18786E-06 None None None None N None 0 2.28843E-05 None 0 0 None 0 0 0 1.4339E-05 0
S/C 4747 Ig-30 48 rs1363033770 0.1826 -0.654 0.997 N 0.4 0.359 0.42989457901 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.61E-05 None 0 None 0 0 0
S/C 4747 Ig-30 48 rs1363033770 0.1826 -0.654 0.997 N 0.4 0.359 0.42989457901 gnomAD-4.0.0 1.59156E-06 None None None None N None 0 0 None 0 2.77932E-05 None 0 0 0 0 0
R/G 4842 Ig-31 48 rs1347409697 0.1812 None None N None 0.204 None gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/G 4842 Ig-31 48 rs1347409697 0.1812 None None N None 0.204 None gnomAD-4.0.0 5.1235E-06 None None None None I None 0 0 None 0 0 None 0 0 9.57089E-06 0 0
R/K 4842 Ig-31 48 rs2742347 0.0617 -0.006 None N 0.159 0.049 None gnomAD-2.1.1 1.00529E-01 None None None None I None 2.17217E-01 2.51202E-01 None 7.19118E-02 2.07162E-01 None 4.21541E-02 None 5.31974E-02 4.74385E-02 7.89326E-02
R/K 4842 Ig-31 48 rs2742347 0.0617 -0.006 None N 0.159 0.049 None gnomAD-3.1.2 1.11237E-01 None None None None I None 2.15318E-01 1.61836E-01 4.82456E-02 7.11816E-02 1.88902E-01 None 5.11128E-02 3.16456E-02 4.81196E-02 4.83002E-02 1.00478E-01
R/K 4842 Ig-31 48 rs2742347 0.0617 -0.006 None N 0.159 0.049 None 1000 genomes 1.44768E-01 None None None None I None 2.284E-01 1.916E-01 None None 1.935E-01 5.17E-02 None None None 4.4E-02 None
R/K 4842 Ig-31 48 rs2742347 0.0617 -0.006 None N 0.159 0.049 None gnomAD-4.0.0 6.69259E-02 None None None None I None 2.1809E-01 2.21052E-01 None 7.19305E-02 1.89543E-01 None 5.40921E-02 3.51485E-02 4.71242E-02 4.27436E-02 7.2869E-02
K/E 4935 Ig-32 48 rs759432239 0.1535 0.093 0.124 N 0.391 0.28 0.282179105231 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 1.66113E-04
K/E 4935 Ig-32 48 rs759432239 0.1535 0.093 0.124 N 0.391 0.28 0.282179105231 gnomAD-4.0.0 4.77445E-06 None None None None N None 0 0 None 0 2.77685E-05 None 1.88416E-05 0 0 0 3.02535E-05
R/L 5029 Ig-33 49 rs200792058 0.2359 None 0.221 N 0.362 0.274 0.596401026678 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/L 5029 Ig-33 49 rs200792058 0.2359 None 0.221 N 0.362 0.274 0.596401026678 gnomAD-4.0.0 6.57333E-06 None None None None N None 2.41406E-05 0 None 0 0 None 0 0 0 0 0
R/Q 5029 Ig-33 49 rs200792058 0.084 -1.07 0.017 N 0.095 0.085 None gnomAD-2.1.1 1.75025E-04 None None None None N None 1.23987E-04 0 None 0 3.07977E-04 None 8.17314E-04 None 0 1.17263E-04 0
R/Q 5029 Ig-33 49 rs200792058 0.084 -1.07 0.017 N 0.095 0.085 None gnomAD-3.1.2 6.57E-05 None None None None N None 0 0 0 0 3.8506E-04 None 0 0 1.02911E-04 2.07469E-04 0
R/Q 5029 Ig-33 49 rs200792058 0.084 -1.07 0.017 N 0.095 0.085 None gnomAD-4.0.0 1.96444E-04 None None None None N None 3.99936E-05 0 None 0 3.12207E-04 None 0 0 1.81396E-04 8.6756E-04 1.12047E-04
R/K 5122 Ig-34 48 rs754945452 0.1181 -0.521 0.061 N 0.147 0.135 0.204665344411 gnomAD-4.0.0 3.18317E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86623E-05 0
R/S 5122 Ig-34 48 rs1275710464 0.6137 None 0.826 N 0.301 0.311 0.267299060538 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/S 5122 Ig-34 48 rs1275710464 0.6137 None 0.826 N 0.301 0.311 0.267299060538 gnomAD-4.0.0 6.57056E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46972E-05 0 0
K/R 5215 Ig-35 48 None 0.0744 None 0.012 N 0.191 0.133 0.192905019026 gnomAD-4.0.0 1.59117E-06 None None None None N None 0 0 None 0 2.773E-05 None 0 0 0 0 0
R/Q 5308 Ig-36 48 rs146847928 0.1857 -0.482 0.993 N 0.497 0.331 None gnomAD-2.1.1 5.71E-05 None None None None N None 1.65399E-04 0 None 0 3.07724E-04 None 6.54E-05 None 4E-05 1.56E-05 1.40449E-04
R/Q 5308 Ig-36 48 rs146847928 0.1857 -0.482 0.993 N 0.497 0.331 None gnomAD-3.1.2 4.6E-05 None None None None N None 4.83E-05 0 0 0 1.9253E-04 None 9.42E-05 3.16456E-03 1.47E-05 0 4.78927E-04
R/Q 5308 Ig-36 48 rs146847928 0.1857 -0.482 0.993 N 0.497 0.331 None 1000 genomes 3.99361E-04 None None None None N None 1.5E-03 0 None None 0 0 None None None 0 None
R/Q 5308 Ig-36 48 rs146847928 0.1857 -0.482 0.993 N 0.497 0.331 None gnomAD-4.0.0 4.15185E-05 None None None None N None 7.99872E-05 0 None 0 1.33738E-04 None 1.56216E-05 1.65071E-04 3.64479E-05 8.78542E-05 3.20154E-05
R/S 5404 Ig-37 48 rs758704167 0.2243 -0.528 0.012 N 0.253 0.12 0.299770980665 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
R/S 5404 Ig-37 48 rs758704167 0.2243 -0.528 0.012 N 0.253 0.12 0.299770980665 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/S 5404 Ig-37 48 rs758704167 0.2243 -0.528 0.012 N 0.253 0.12 0.299770980665 gnomAD-4.0.0 1.30154E-05 None None None None I None 0 0 None 0 0 None 0 0 1.69528E-05 0 1.60164E-05
Y/C 5497 Ig-38 48 rs946624122 0.154 None 1.0 N 0.697 0.361 0.611492100817 gnomAD-4.0.0 4.78982E-06 None None None None I None 2.98739E-05 0 None 0 2.52232E-05 None 0 0 3.59801E-06 0 1.65695E-05
Y/H 5497 Ig-38 48 rs1279249843 0.1388 -0.236 0.998 N 0.575 0.3 0.386395597597 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
Y/H 5497 Ig-38 48 rs1279249843 0.1388 -0.236 0.998 N 0.575 0.3 0.386395597597 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 0 4.77555E-04
Y/H 5497 Ig-38 48 rs1279249843 0.1388 -0.236 0.998 N 0.575 0.3 0.386395597597 gnomAD-4.0.0 3.84389E-06 None None None None I None 0 0 None 0 0 None 0 0 4.78675E-06 0 2.84495E-05
Y/N 5497 Ig-38 48 rs1279249843 0.152 None 0.998 N 0.693 0.458 0.634143885914 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 9.96E-05 0 None 0 None 0 0 0
Y/N 5497 Ig-38 48 rs1279249843 0.152 None 0.998 N 0.693 0.458 0.634143885914 gnomAD-4.0.0 1.59155E-06 None None None None I None 0 0 None 4.7669E-05 0 None 0 0 0 0 0
R/I 5591 Ig-39 49 rs750316973 0.1082 -0.159 0.001 N 0.243 0.179 0.222439326576 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 2.22643E-04 None 0 None 0 0 0
R/I 5591 Ig-39 49 rs750316973 0.1082 -0.159 0.001 N 0.243 0.179 0.222439326576 gnomAD-4.0.0 1.0263E-05 None None None None N None 0 0 None 0 1.00776E-04 None 0 0 9.89408E-06 0 0
R/G 5777 Ig-41 48 None 0.2475 None 0.081 N 0.332 0.256 0.462111473445 gnomAD-4.0.0 1.59129E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
R/K 5777 Ig-41 48 rs759657332 0.0815 None None N 0.085 0.144 0.238096912614 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/K 5777 Ig-41 48 rs759657332 0.0815 None None N 0.085 0.144 0.238096912614 gnomAD-4.0.0 2.4789E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54283E-06 1.09801E-05 0
R/S 5777 Ig-41 48 rs367942154 0.3491 -0.511 0.003 N 0.189 0.285 0.250039746154 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.55E-05 0
R/S 5777 Ig-41 48 rs367942154 0.3491 -0.511 0.003 N 0.189 0.285 0.250039746154 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
R/S 5777 Ig-41 48 rs367942154 0.3491 -0.511 0.003 N 0.189 0.285 0.250039746154 gnomAD-4.0.0 8.05629E-06 None None None None N None 0 0 None 0 0 None 0 0 1.01713E-05 0 1.60128E-05
R/T 5777 Ig-41 48 rs759657332 0.1688 -0.218 None N 0.171 0.294 0.273503213844 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/T 5777 Ig-41 48 rs759657332 0.1688 -0.218 None N 0.171 0.294 0.273503213844 gnomAD-4.0.0 6.84215E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
K/E 5870 Ig-42 48 None 0.3354 None 0.999 N 0.569 0.444 0.455816718377 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/T 5966 Ig-43 48 rs1469567732 0.2436 -0.896 0.999 N 0.667 0.501 0.462809833587 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/T 5966 Ig-43 48 rs1469567732 0.2436 -0.896 0.999 N 0.667 0.501 0.462809833587 gnomAD-4.0.0 2.73703E-06 None None None None N None 0 2.23644E-05 None 0 0 None 0 0 2.69862E-06 0 0
S/L 6059 Ig-44 48 None 0.1248 None 0.978 N 0.491 0.318 0.681597050132 gnomAD-4.0.0 2.05306E-06 None None None None N None 0 0 None 3.82907E-05 0 None 0 0 1.79911E-06 0 0
G/D 6153 Ig-45 49 rs374460910 0.1271 -0.924 0.896 N 0.472 0.342 None gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 9.95E-05 0 None 0 None 0 8.88E-06 0
G/D 6153 Ig-45 49 rs374460910 0.1271 -0.924 0.896 N 0.472 0.342 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/D 6153 Ig-45 49 rs374460910 0.1271 -0.924 0.896 N 0.472 0.342 None gnomAD-4.0.0 1.11553E-05 None None None None I None 0 1.66778E-05 None 3.37883E-05 0 None 0 0 1.18671E-05 0 3.20246E-05
T/A 6246 Ig-46 48 rs1553920950 0.0697 None None N 0.102 0.12 0.134241683229 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
T/I 6246 Ig-46 48 rs1252010867 0.0837 -0.041 0.001 N 0.277 0.081 0.239305524855 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/I 6246 Ig-46 48 rs1252010867 0.0837 -0.041 0.001 N 0.277 0.081 0.239305524855 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 1.92976E-04 None 0 0 1.47E-05 0 0
T/I 6246 Ig-46 48 rs1252010867 0.0837 -0.041 0.001 N 0.277 0.081 0.239305524855 gnomAD-4.0.0 9.13489E-06 None None None None N None 0 0 None 0 1.13482E-04 None 0 0 9.63946E-06 0 0
Y/C 6339 Ig-47 48 rs192553687 0.0659 -0.096 0.258 N 0.381 0.19 None gnomAD-2.1.1 1.1502E-04 None None None None I None 8.32E-05 2.84E-05 None 0 0 None 0 None 0 2.04905E-04 4.25411E-04
Y/C 6339 Ig-47 48 rs192553687 0.0659 -0.096 0.258 N 0.381 0.19 None gnomAD-3.1.2 2.10352E-04 None None None None I None 2.65457E-04 1.31044E-04 0 0 1.93199E-04 None 0 0 2.6462E-04 0 0
Y/C 6339 Ig-47 48 rs192553687 0.0659 -0.096 0.258 N 0.381 0.19 None gnomAD-4.0.0 3.65773E-04 None None None None I None 1.86657E-04 5.00969E-05 None 0 4.46907E-05 None 0 0 4.72228E-04 2.19809E-05 1.92234E-04
Y/D 6339 Ig-47 48 None 0.0775 None 0.001 N 0.387 0.266 0.311691414656 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/L 6432 Ig-48 48 None 0.1053 None 0.015 N 0.431 0.231 0.618519337204 gnomAD-4.0.0 6.84443E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99627E-07 0 0
R/K 6528 Ig-49 48 rs779960008 0.0982 -0.334 0.001 N 0.151 0.099 0.208000267992 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/K 6528 Ig-49 48 rs779960008 0.0982 -0.334 0.001 N 0.151 0.099 0.208000267992 gnomAD-4.0.0 1.59265E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43345E-05 0
F/L 6621 Ig-50 48 rs760276555 0.8662 -1.128 0.026 N 0.165 0.187 0.313518423057 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 8.88E-06 0
F/L 6621 Ig-50 48 rs760276555 0.8662 -1.128 0.026 N 0.165 0.187 0.313518423057 gnomAD-4.0.0 4.77693E-06 None None None None N None 0 0 None 0 2.77393E-05 None 0 0 2.86067E-06 0 3.0259E-05
K/T 6808 Ig-52 48 None 0.6641 None 0.864 N 0.537 0.332 0.42069145522 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 6.07533E-05 0
R/K 6902 Ig-53 49 None 0.0876 None 0.001 N 0.118 0.096 0.181679512989 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/M 6902 Ig-53 49 rs2079182473 0.1913 None 0.963 N 0.395 0.479 0.444305618086 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/M 6902 Ig-53 49 rs2079182473 0.1913 None 0.963 N 0.395 0.479 0.444305618086 gnomAD-4.0.0 6.57324E-06 None None None None N None 2.41313E-05 0 None 0 0 None 0 0 0 0 0
K/E 6995 Ig-54 48 None 0.2285 None 0.977 N 0.518 0.321 0.40017627803 gnomAD-4.0.0 6.84322E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99596E-07 0 0
N/D 7184 Ig-56 48 rs1366031789 0.1231 -1.06 0.704 D 0.401 0.234 0.322786055943 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
N/D 7184 Ig-56 48 rs1366031789 0.1231 -1.06 0.704 D 0.401 0.234 0.322786055943 gnomAD-4.0.0 6.36876E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.73378E-05 0
N/S 7184 Ig-56 48 None 0.0805 None 0.31 N 0.136 0.107 0.171388866994 gnomAD-4.0.0 1.5922E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85969E-06 0 0
N/D 7277 Ig-57 48 rs758247611 0.1126 -1.275 0.029 D 0.295 0.157 None gnomAD-2.1.1 1.07E-05 None None None None N None 1.24049E-04 0 None 0 0 None 0 None 0 0 0
N/D 7277 Ig-57 48 rs758247611 0.1126 -1.275 0.029 D 0.295 0.157 None gnomAD-3.1.2 2.63E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
N/D 7277 Ig-57 48 rs758247611 0.1126 -1.275 0.029 D 0.295 0.157 None gnomAD-4.0.0 4.95831E-06 None None None None N None 1.06815E-04 0 None 0 0 None 0 0 0 0 0
Q/H 7466 Ig-59 48 rs1378606339 0.2446 None 0.01 N 0.19 0.184 0.263612267334 gnomAD-4.0.0 1.59206E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.4332E-05 0
T/I 7562 Ig-60 48 rs1553909660 0.1441 None 0.642 N 0.428 0.203 0.506373324096 gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
T/I 7562 Ig-60 48 rs1553909660 0.1441 None 0.642 N 0.428 0.203 0.506373324096 gnomAD-4.0.0 1.31439E-05 None None None None N None 4.82486E-05 0 None 0 0 None 0 0 0 0 0
T/R 7562 Ig-60 48 None 0.1445 None 0.002 N 0.218 0.268 0.504297271243 gnomAD-4.0.0 1.5918E-06 None None None None N None 0 0 None 0 2.77285E-05 None 0 0 0 0 0
N/D 7656 Ig-61 49 rs184123332 0.0989 -0.716 0.116 N 0.235 0.193 None gnomAD-2.1.1 2.01E-05 None None None None I None 0 0 None 0 1.66963E-04 None 6.54E-05 None 0 0 0
N/D 7656 Ig-61 49 rs184123332 0.0989 -0.716 0.116 N 0.235 0.193 None gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 7.71903E-04 None 0 0 0 0 0
N/D 7656 Ig-61 49 rs184123332 0.0989 -0.716 0.116 N 0.235 0.193 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
N/D 7656 Ig-61 49 rs184123332 0.0989 -0.716 0.116 N 0.235 0.193 None gnomAD-4.0.0 8.73922E-05 None None None None I None 0 0 None 0 3.09839E-03 None 0 0 0 2.19679E-05 0
N/K 7656 Ig-61 49 None 0.0996 None 0.001 N 0.08 0.168 0.17948927462 gnomAD-4.0.0 6.84423E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.65733E-05
N/S 7656 Ig-61 49 rs1197475799 0.0635 -0.097 0.002 N 0.1 0.092 0.165133752707 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/S 7656 Ig-61 49 rs1197475799 0.0635 -0.097 0.002 N 0.1 0.092 0.165133752707 gnomAD-4.0.0 1.59231E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43357E-05 0
K/T 7749 Ig-62 48 None 0.5814 None 0.883 N 0.333 0.328 0.386721274199 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/M 7843 Ig-63 49 None 0.1555 None 0.602 N 0.346 0.252 0.258779203287 gnomAD-4.0.0 1.59144E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85878E-06 0 0
H/P 7936 Ig-64 48 None 0.274 None 0.202 N 0.517 0.329 0.410868550352 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/R 8032 Ig-65 48 rs529079424 0.0777 0.532 None N 0.093 0.166 0.208816687407 gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
Q/R 8032 Ig-65 48 rs529079424 0.0777 0.532 None N 0.093 0.166 0.208816687407 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
Q/R 8032 Ig-65 48 rs529079424 0.0777 0.532 None N 0.093 0.166 0.208816687407 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
Q/R 8032 Ig-65 48 rs529079424 0.0777 0.532 None N 0.093 0.166 0.208816687407 gnomAD-4.0.0 3.84283E-06 None None None None I None 0 0 None 0 0 None 0 0 0 4.02037E-05 0
N/S 8125 Ig-66 48 None 0.0693 None None N 0.091 0.144 0.134241683229 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/G 8218 Ig-67 48 rs72648980 0.0902 -0.902 None N 0.141 0.107 None gnomAD-2.1.1 8.46876E-04 None None None None I None 8.51451E-03 5.37726E-04 None 0 0 None 0 None 0 8.61E-05 1.40528E-04
S/G 8218 Ig-67 48 rs72648980 0.0902 -0.902 None N 0.141 0.107 None gnomAD-3.1.2 2.46435E-03 None None None None I None 8.1544E-03 1.89815E-03 0 0 0 None 0 0 7.35E-05 0 1.43267E-03
S/G 8218 Ig-67 48 rs72648980 0.0902 -0.902 None N 0.141 0.107 None 1000 genomes 1.59744E-03 None None None None I None 4.5E-03 2.9E-03 None None 0 0 None None None 0 None
S/G 8218 Ig-67 48 rs72648980 0.0902 -0.902 None N 0.141 0.107 None gnomAD-4.0.0 4.64121E-04 None None None None I None 8.11589E-03 1.01643E-03 None 0 0 None 1.56201E-05 1.65017E-04 3.81439E-05 0 5.12197E-04
S/N 8218 Ig-67 48 rs1205977275 0.0875 -0.584 None N 0.163 0.064 0.134241683229 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/N 8218 Ig-67 48 rs1205977275 0.0875 -0.584 None N 0.163 0.064 0.134241683229 gnomAD-4.0.0 3.18274E-06 None None None None I None 0 4.57352E-05 None 0 0 None 0 0 0 0 0
K/N 8311 Ig-68 48 rs749075617 0.6707 -0.049 0.999 N 0.505 0.304 0.17258766438 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/N 8311 Ig-68 48 rs749075617 0.6707 -0.049 0.999 N 0.505 0.304 0.17258766438 gnomAD-4.0.0 1.59155E-06 None None None None N None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
Q/H 8407 Ig-69 48 rs1381783502 0.272 None 0.997 N 0.426 0.303 0.199424873507 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/H 8407 Ig-69 48 rs1381783502 0.272 None 0.997 N 0.426 0.303 0.199424873507 gnomAD-4.0.0 3.84524E-06 None None None None I None 0 0 None 0 0 None 0 0 7.18233E-06 0 0
K/E 8503 Ig-70 48 rs1336555903 0.4657 0.368 0.947 N 0.419 0.252 0.317958651998 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
K/E 8503 Ig-70 48 rs1336555903 0.4657 0.368 0.947 N 0.419 0.252 0.317958651998 gnomAD-4.0.0 1.59166E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8591E-06 0 0
K/R 8503 Ig-70 48 rs765512040 0.0895 -0.255 0.064 N 0.313 0.135 0.213573922156 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 0 None 0 0 6.6335E-04
K/R 8503 Ig-70 48 rs765512040 0.0895 -0.255 0.064 N 0.313 0.135 0.213573922156 gnomAD-4.0.0 5.47424E-06 None None None None N None 0 0 None 0 0 None 0 8.67152E-04 8.99552E-07 0 3.31411E-05
K/T 8503 Ig-70 48 rs765512040 0.4082 -0.627 0.996 N 0.511 0.464 0.45882554386 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/T 8503 Ig-70 48 rs765512040 0.4082 -0.627 0.996 N 0.511 0.464 0.45882554386 gnomAD-4.0.0 6.8428E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15937E-05 0
K/E 8690 Ig-72 48 rs1060500411 0.7328 0.24 0.991 N 0.492 0.384 0.397391247328 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 4.64E-05 0 0
K/E 8690 Ig-72 48 rs1060500411 0.7328 0.24 0.991 N 0.492 0.384 0.397391247328 gnomAD-4.0.0 3.18278E-06 None None None None N None 0 0 None 0 0 None 3.76464E-05 0 0 0 0
K/R 8690 Ig-72 48 rs755911258 0.1083 -0.419 0.34 N 0.256 0.098 0.235038932564 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
K/R 8690 Ig-72 48 rs755911258 0.1083 -0.419 0.34 N 0.256 0.098 0.235038932564 gnomAD-4.0.0 1.36847E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79904E-06 0 0
W/R 8784 Ig-73 49 rs375067750 0.1403 -0.1 0.005 N 0.323 0.243 0.427254322456 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 1.66113E-04
W/R 8784 Ig-73 49 rs375067750 0.1403 -0.1 0.005 N 0.323 0.243 0.427254322456 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
W/R 8784 Ig-73 49 rs375067750 0.1403 -0.1 0.005 N 0.323 0.243 0.427254322456 gnomAD-4.0.0 1.30137E-05 None None None None N None 0 0 None 0 0 None 0 0 1.78001E-05 0 0
N/H 9066 Ig-76 48 None 0.0883 None 0.999 N 0.525 0.27 0.300449992093 gnomAD-4.0.0 7.20193E-06 None None None None N None 0 0 None 0 0 None 0 0 7.87501E-06 0 0
N/K 9066 Ig-76 48 rs369529493 0.2256 0.051 0.984 N 0.435 0.208 0.124217242631 gnomAD-2.1.1 1.2876E-04 None None None None N None 0 0 None 0 0 None 0 None 4.64E-05 2.66809E-04 1.65948E-04
N/K 9066 Ig-76 48 rs369529493 0.2256 0.051 0.984 N 0.435 0.208 0.124217242631 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 9.43E-05 0 1.47E-05 0 0
N/K 9066 Ig-76 48 rs369529493 0.2256 0.051 0.984 N 0.435 0.208 0.124217242631 gnomAD-4.0.0 1.36846E-06 None None None None N None 0 0 None 0 2.52016E-05 None 0 0 8.99475E-07 0 0
N/S 9066 Ig-76 48 rs2076861008 0.0774 None 0.659 N 0.258 0.152 0.194818534648 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
N/S 9066 Ig-76 48 rs2076861008 0.0774 None 0.659 N 0.258 0.152 0.194818534648 gnomAD-4.0.0 3.09854E-06 None None None None N None 1.33476E-05 1.66739E-05 None 0 0 None 0 0 0 0 4.80369E-05
N/S 9159 Ig-77 48 None 0.0641 None None N 0.133 0.084 0.0401082797425 gnomAD-4.0.0 1.59116E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85804E-06 0 0
Q/E 9348 Ig-79 48 rs794727987 0.1168 -0.301 0.425 None 0.314 0.167 0.221019684889 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14863E-04 0 None 0 0 None 0 None 0 0 0
Q/E 9348 Ig-79 48 rs794727987 0.1168 -0.301 0.425 None 0.314 0.167 0.221019684889 gnomAD-3.1.2 3.95E-05 None None None None I None 1.44928E-04 0 0 0 0 None 0 0 0 0 0
Q/E 9348 Ig-79 48 rs794727987 0.1168 -0.301 0.425 None 0.314 0.167 0.221019684889 gnomAD-4.0.0 4.33796E-06 None None None None I None 8.01346E-05 0 None 0 0 None 0 0 0 0 1.60097E-05
Q/H 9348 Ig-79 48 None 0.2706 None 0.006 None 0.249 0.072 0.139678290688 gnomAD-4.0.0 6.84179E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
Q/K 9348 Ig-79 48 None 0.1101 None 0.425 None 0.295 0.206 0.202086224978 gnomAD-4.0.0 1.36836E-06 None None None None I None 2.98739E-05 0 None 0 0 None 0 0 0 1.15934E-05 0
Q/R 9348 Ig-79 48 rs1414782408 0.1165 None 0.642 None 0.273 0.146 0.195762928549 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/R 9348 Ig-79 48 rs1414782408 0.1165 None 0.642 None 0.273 0.146 0.195762928549 gnomAD-4.0.0 6.57281E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
Q/R 9444 Ig-80 48 None 0.0859 None 0.27 None 0.3 0.165 0.229924730088 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 9541 Ig-81 49 rs2076382239 0.2014 None 0.005 None 0.117 0.247 0.303453137403 gnomAD-4.0.0 1.5911E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
S/G 9637 Ig-82 48 rs1160550023 0.1003 -0.812 0.012 None 0.292 0.23 0.246215685461 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
S/N 9637 Ig-82 48 None 0.0981 None None None 0.167 0.096 0.185906805712 gnomAD-4.0.0 1.36836E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79883E-06 0 0
S/R 9637 Ig-82 48 rs1160550023 0.3671 None None None 0.323 0.24 0.252162846088 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/R 9637 Ig-82 48 rs1160550023 0.3671 None None None 0.323 0.24 0.252162846088 gnomAD-4.0.0 6.56996E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46998E-05 0 0
F/S 9746 Ig-83 49 None 0.1941 None None None 0.131 0.093 0.372268306217 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
N/K 10124 Ig-86 47 rs1163704372 0.8055 0.073 0.801 None 0.37 0.249 0.165133752707 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/K 10124 Ig-86 47 rs1163704372 0.8055 0.073 0.801 None 0.37 0.249 0.165133752707 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
N/K 10124 Ig-86 47 rs1163704372 0.8055 0.073 0.801 None 0.37 0.249 0.165133752707 gnomAD-4.0.0 2.56176E-06 None None None None N None 1.69182E-05 0 None 0 0 None 0 0 0 1.34009E-05 0
N/T 10124 Ig-86 47 None 0.2791 None 0.051 None 0.14 0.133 0.230578612272 gnomAD-4.0.0 1.59085E-06 None None None None N None 0 0 None 0 2.77254E-05 None 0 0 0 0 0
N/Y 10124 Ig-86 47 rs2075188829 0.4476 None 0.989 None 0.551 0.55 0.645059290664 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92308E-04 None 0 0 0 0 0
N/Y 10124 Ig-86 47 rs2075188829 0.4476 None 0.989 None 0.551 0.55 0.645059290664 gnomAD-4.0.0 6.57289E-06 None None None None N None 0 0 None 0 1.92308E-04 None 0 0 0 0 0
R/K 13733 Ig-87 50 rs1026532541 0.2761 None 0.002 N 0.104 0.097 0.259761712551 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
R/K 13733 Ig-87 50 rs1026532541 0.2761 None 0.002 N 0.104 0.097 0.259761712551 gnomAD-4.0.0 1.31572E-05 None None None None N None 4.82789E-05 0 None 0 0 None 0 0 0 0 0
V/E 13827 Ig-88 48 None 0.4883 None 0.27 N 0.335 0.18 0.296329037015 gnomAD-4.0.0 4.79082E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29744E-06 0 0
V/G 13827 Ig-88 48 None 0.4962 None 0.27 N 0.381 0.185 0.369682402691 gnomAD-4.0.0 6.84403E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99635E-07 0 0
V/L 13827 Ig-88 48 None 0.2547 None 0.139 N 0.197 0.043 0.24896430686 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 14011 Ig-90 47 None 0.7957 None 0.115 N 0.478 0.159 0.151104730317 gnomAD-4.0.0 1.60873E-06 None None None None N None 0 0 None 0 2.78474E-05 None 0 0 0 0 0
D/G 14099 Ig-91 46 rs1295172213 0.4349 None 0.989 N 0.471 0.372 0.332902724076 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/G 14099 Ig-91 46 rs1295172213 0.4349 None 0.989 N 0.471 0.372 0.332902724076 gnomAD-4.0.0 3.7194E-06 None None None None N None 1.33601E-05 0 None 0 0 None 0 0 3.39117E-06 0 1.6021E-05
D/H 14099 Ig-91 46 None 0.4021 None 1.0 N 0.641 0.337 0.348101942276 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 14099 Ig-91 46 rs1041549928 0.1628 None 0.998 N 0.527 0.305 0.312001716656 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
D/N 14099 Ig-91 46 rs1041549928 0.1628 None 0.998 N 0.527 0.305 0.312001716656 gnomAD-4.0.0 4.06037E-06 None None None None N None 3.49638E-05 0 None 0 0 None 0 0 2.40995E-06 0 0
L/F 14188 Ig-92 47 rs558930798 0.0979 -0.752 0.007 N 0.19 0.123 0.628906646486 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.91E-06 0
L/F 14188 Ig-92 47 rs558930798 0.0979 -0.752 0.007 N 0.19 0.123 0.628906646486 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 2.07125E-04 0
L/F 14188 Ig-92 47 rs558930798 0.0979 -0.752 0.007 N 0.19 0.123 0.628906646486 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
L/F 14188 Ig-92 47 rs558930798 0.0979 -0.752 0.007 N 0.19 0.123 0.628906646486 gnomAD-4.0.0 3.71888E-06 None None None None N None 0 0 None 0 0 None 0 0 4.23887E-06 1.09801E-05 0
L/R 14188 Ig-92 47 None 0.1164 None 0.782 N 0.609 0.33 0.731283324975 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
L/V 14188 Ig-92 47 None 0.0781 None 0.013 N 0.195 0.122 0.570372710236 gnomAD-4.0.0 6.84339E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99622E-07 0 0
S/A 14276 Ig-93 46 None 0.086 None 0.061 N 0.143 0.103 0.166414681773 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
S/F 14276 Ig-93 46 rs2060063750 0.1998 None 0.996 N 0.587 0.385 0.737229180969 gnomAD-4.0.0 1.59218E-06 None None None None N None 0 2.2877E-05 None 0 0 None 0 0 0 0 0
E/K 14365 Ig-94 47 rs1302907540 0.1856 None 0.997 N 0.757 0.416 0.276898752692 gnomAD-4.0.0 9.60257E-06 None None None None N None 0 0 None 0 0 None 0 0 1.05E-05 0 0
E/D 14454 Ig-95 47 rs878912118 0.198 -0.873 0.996 N 0.392 0.173 0.392239652056 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/D 14454 Ig-95 47 rs878912118 0.198 -0.873 0.996 N 0.392 0.173 0.392239652056 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/D 14454 Ig-95 47 rs878912118 0.198 -0.873 0.996 N 0.392 0.173 0.392239652056 gnomAD-4.0.0 6.84319E-07 None None None None N None 0 2.23654E-05 None 0 0 None 0 0 0 0 0
E/G 14454 Ig-95 47 None 0.2432 None 0.999 N 0.651 0.429 0.528009843598 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/A 14543 Ig-96 47 None 0.0939 None 0.052 N 0.39 0.234 0.247322355667 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 14632 Ig-97 47 rs750807748 0.1151 -1.473 None N 0.137 0.108 0.247322355667 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
V/A 14632 Ig-97 47 rs750807748 0.1151 -1.473 None N 0.137 0.108 0.247322355667 gnomAD-4.0.0 1.36877E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79918E-06 0 0
V/I 14632 Ig-97 47 rs1456607091 0.0676 None None N 0.137 0.075 0.17258766438 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
V/I 14632 Ig-97 47 rs1456607091 0.0676 None None N 0.137 0.075 0.17258766438 gnomAD-4.0.0 6.57531E-06 None None None None N None 0 6.5548E-05 None 0 0 None 0 0 0 0 0
D/V 14988 Ig-101 47 rs1478836616 0.5791 None 0.997 N 0.703 0.491 0.444505407614 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
D/V 14988 Ig-101 47 rs1478836616 0.5791 None 0.997 N 0.703 0.491 0.444505407614 gnomAD-4.0.0 1.98612E-05 None None None None N None 0 0 None 3.38776E-05 0 None 0 0 2.63023E-05 0 0
E/G 15077 Ig-102 47 None 0.2676 None 0.999 D 0.677 0.424 0.55046033382 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
D/N 15166 Ig-103 47 None 0.1184 None 0.98 N 0.429 0.252 0.412587454835 gnomAD-4.0.0 1.59415E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86254E-06 0 0
D/V 15166 Ig-103 47 rs2154211726 0.2498 None 0.994 N 0.536 0.448 0.552698843619 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/V 15166 Ig-103 47 rs2154211726 0.2498 None 0.994 N 0.536 0.448 0.552698843619 gnomAD-4.0.0 6.58111E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47314E-05 0 0
I/F 15254 Ig-104 47 rs72677226 0.2116 -1.073 0.988 D 0.391 0.254 0.710200110468 gnomAD-2.1.1 1.21199E-04 None None None None I None 6.47E-05 8.4268E-04 None 0 0 None 0 None 0 0 0
I/F 15254 Ig-104 47 rs72677226 0.2116 -1.073 0.988 D 0.391 0.254 0.710200110468 gnomAD-3.1.2 3.29E-05 None None None None I None 4.83E-05 1.96876E-04 0 0 0 None 0 0 0 0 0
I/F 15254 Ig-104 47 rs72677226 0.2116 -1.073 0.988 D 0.391 0.254 0.710200110468 gnomAD-4.0.0 5.13194E-05 None None None None I None 3.38972E-05 5.94167E-04 None 0 0 None 0 0 0 0 8.54896E-05
I/M 15254 Ig-104 47 None 0.1145 None 0.988 N 0.438 0.286 0.506552580704 gnomAD-4.0.0 1.59356E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86259E-06 0 0
I/N 15254 Ig-104 47 rs2058156310 0.2981 None 0.988 N 0.526 0.552 0.842181085062 gnomAD-3.1.2 6.6E-06 None None None None I None 0 6.57E-05 0 0 0 None 0 0 0 0 0
I/N 15254 Ig-104 47 rs2058156310 0.2981 None 0.988 N 0.526 0.552 0.842181085062 gnomAD-4.0.0 6.5957E-06 None None None None I None 0 6.57289E-05 None 0 0 None 0 0 0 0 0
I/V 15254 Ig-104 47 rs72677226 0.0773 -0.823 0.238 N 0.143 0.07 0.51759925163 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/V 15254 Ig-104 47 rs72677226 0.0773 -0.823 0.238 N 0.143 0.07 0.51759925163 gnomAD-4.0.0 1.59356E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43336E-05 0
S/A 15348 Ig-105 47 rs766291551 0.0882 -0.709 0.001 N 0.256 0.082 0.0846915920261 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
S/A 15348 Ig-105 47 rs766291551 0.0882 -0.709 0.001 N 0.256 0.082 0.0846915920261 gnomAD-4.0.0 1.59412E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.0303E-05
K/T 15437 Ig-106 47 rs552087956 0.1396 -1.017 0.001 N 0.152 0.186 0.227260227426 gnomAD-2.1.1 4.1E-06 None None None None N None 6.5E-05 0 None 0 0 None 0 None 0 0 0
K/T 15437 Ig-106 47 rs552087956 0.1396 -1.017 0.001 N 0.152 0.186 0.227260227426 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
K/T 15437 Ig-106 47 rs552087956 0.1396 -1.017 0.001 N 0.152 0.186 0.227260227426 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
K/T 15437 Ig-106 47 rs552087956 0.1396 -1.017 0.001 N 0.152 0.186 0.227260227426 gnomAD-4.0.0 6.57895E-06 None None None None N None 2.40801E-05 0 None 0 0 None 0 0 0 0 0
Q/L 15526 Ig-107 47 None 0.2972 None 0.997 N 0.545 0.5 0.575346514103 gnomAD-4.0.0 1.5938E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86387E-06 0 0
T/A 15612 Ig-108 45 rs2057779557 0.069 None 0.454 N 0.262 0.11 0.186928172975 gnomAD-3.1.2 6.59E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
T/A 15612 Ig-108 45 rs2057779557 0.069 None 0.454 N 0.262 0.11 0.186928172975 gnomAD-4.0.0 6.58519E-06 None None None None N None 2.41604E-05 0 None 0 0 None 0 0 0 0 0
T/A 16306 Ig-110 45 rs767671184 0.0833 -0.759 0.64 N 0.361 0.101 0.229264304666 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/A 16306 Ig-110 45 rs767671184 0.0833 -0.759 0.64 N 0.361 0.101 0.229264304666 gnomAD-4.0.0 6.84727E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65898E-05
T/I 16306 Ig-110 45 rs2056961264 0.134 None 0.984 N 0.476 0.282 0.445007932271 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07987E-04 0
T/I 16306 Ig-110 45 rs2056961264 0.134 None 0.984 N 0.476 0.282 0.445007932271 gnomAD-4.0.0 6.59074E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07987E-04 0
T/P 16306 Ig-110 45 rs767671184 0.7528 -0.438 0.984 D 0.465 0.47 0.394685799254 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66945E-04
T/P 16306 Ig-110 45 rs767671184 0.7528 -0.438 0.984 D 0.465 0.47 0.394685799254 gnomAD-4.0.0 3.42364E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49947E-06 0 0
S/N 17323 Ig-112 73 None 0.1631 None 0.002 N 0.273 0.114 0.227934060464 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
V/A 17719 Ig-113 43 rs564121832 0.1505 -1.473 0.027 N 0.288 0.079 0.543031892603 gnomAD-2.1.1 1.28815E-04 None None None None N None 0 0 None 0 0 None 9.15092E-04 None 0 3.56E-05 0
V/A 17719 Ig-113 43 rs564121832 0.1505 -1.473 0.027 N 0.288 0.079 0.543031892603 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 0 1.0352E-03 0
V/A 17719 Ig-113 43 rs564121832 0.1505 -1.473 0.027 N 0.288 0.079 0.543031892603 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
V/A 17719 Ig-113 43 rs564121832 0.1505 -1.473 0.027 N 0.288 0.079 0.543031892603 gnomAD-4.0.0 7.43864E-05 None None None None N None 0 0 None 0 0 None 0 3.3036E-04 2.71335E-05 8.78503E-04 9.60922E-05
Q/E 18434 Ig-115 53 None 0.0921 None 0.309 N 0.435 0.074 0.222439326576 gnomAD-4.0.0 1.59882E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8665E-06 0 0
N/K 18739 Ig-116 52 rs773116579 0.3501 -0.417 0.996 N 0.507 0.262 0.206339911435 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
N/S 18739 Ig-116 52 None 0.0884 None 0.905 N 0.383 0.269 0.198526703765 gnomAD-4.0.0 1.59285E-06 None None None None N None 0 0 None 0 0 None 1.88281E-05 0 0 0 0
H/D 19434 Ig-118 44 rs770789921 0.1559 -1.006 0.003 N 0.307 0.102 0.287603790349 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
H/D 19434 Ig-118 44 rs770789921 0.1559 -1.006 0.003 N 0.307 0.102 0.287603790349 gnomAD-4.0.0 4.77572E-06 None None None None N None 0 4.57582E-05 None 0 0 None 0 0 2.85919E-06 0 0
T/I 20126 Ig-120 47 rs772536475 0.1022 -0.019 0.301 N 0.421 0.108 0.376393476264 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/I 20126 Ig-120 47 rs772536475 0.1022 -0.019 0.301 N 0.421 0.108 0.376393476264 gnomAD-4.0.0 1.09497E-05 None None None None N None 0 0 None 0 0 None 0 0 1.34947E-05 1.15974E-05 0
T/K 20126 Ig-120 47 None 0.1159 None None N 0.146 0.197 0.298745278005 gnomAD-4.0.0 2.05308E-06 None None None None N None 8.97183E-05 0 None 0 0 None 0 0 0 0 0
T/R 20126 Ig-120 47 rs772536475 0.1069 -0.387 0.042 N 0.368 0.192 0.376921832658 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
T/R 20126 Ig-120 47 rs772536475 0.1069 -0.387 0.042 N 0.368 0.192 0.376921832658 gnomAD-4.0.0 6.84359E-07 None None None None N None 0 0 None 0 2.51965E-05 None 0 0 0 0 0
D/G 20524 Ig-121 46 None 0.1875 None 0.012 N 0.355 0.223 0.258779203287 gnomAD-4.0.0 1.5926E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86035E-06 0 0
K/E 20819 Ig-122 51 rs561142365 0.182 0.684 0.334 N 0.431 0.251 0.247872288689 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 2.23514E-04 None 0 None 0 0 0
K/E 20819 Ig-122 51 rs561142365 0.182 0.684 0.334 N 0.431 0.251 0.247872288689 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 3.88199E-04 None 0 0 0 0 0
K/E 20819 Ig-122 51 rs561142365 0.182 0.684 0.334 N 0.431 0.251 0.247872288689 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
K/E 20819 Ig-122 51 rs561142365 0.182 0.684 0.334 N 0.431 0.251 0.247872288689 gnomAD-4.0.0 4.95825E-06 None None None None N None 0 0 None 0 1.78707E-04 None 0 0 0 0 0
K/N 20819 Ig-122 51 rs2049719955 0.2983 None 0.004 N 0.173 0.076 0.141422826196 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/N 20819 Ig-122 51 rs2049719955 0.2983 None 0.004 N 0.173 0.076 0.141422826196 gnomAD-4.0.0 1.85953E-06 None None None None N None 4.00545E-05 0 None 0 0 None 0 0 0 0 0
K/R 20819 Ig-122 51 rs780962150 0.0828 None 0.549 N 0.421 0.107 0.299770980665 gnomAD-4.0.0 1.71084E-05 None None None None N None 0 0 None 0 0 None 0 0 2.24893E-05 0 0
Q/H 21221 Ig-123 45 None 0.1976 None 0.015 N 0.131 0.128 0.101711395817 gnomAD-4.0.0 1.59339E-06 None None None None I None 0 2.28906E-05 None 0 0 None 0 0 0 0 0
Q/K 21221 Ig-123 45 rs2049322891 0.1265 None 0.826 N 0.376 0.246 0.219573609325 gnomAD-4.0.0 1.5935E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86092E-06 0 0
A/V 21514 Ig-124 46 rs1060500520 0.1694 None 0.026 N 0.231 0.142 0.394837016283 gnomAD-4.0.0 2.05314E-06 None None None None N None 2.98972E-05 0 None 0 0 None 0 0 1.79937E-06 0 0
K/E 21911 Ig-125 46 rs372565084 0.3606 -0.37 0.999 N 0.559 0.415 None gnomAD-2.1.1 2.9E-05 None None None None N None 3.34364E-04 0 None 0 0 None 0 None 0 0 0
K/E 21911 Ig-125 46 rs372565084 0.3606 -0.37 0.999 N 0.559 0.415 None gnomAD-3.1.2 9.2E-05 None None None None N None 3.13676E-04 6.55E-05 0 0 0 None 0 0 0 0 0
K/E 21911 Ig-125 46 rs372565084 0.3606 -0.37 0.999 N 0.559 0.415 None gnomAD-4.0.0 1.6135E-05 None None None None N None 3.33992E-04 1.67274E-05 None 0 0 None 0 0 0 0 0
K/N 21911 Ig-125 46 rs1226949981 0.575 None 1.0 N 0.691 0.372 0.282179105231 gnomAD-4.0.0 1.11798E-05 None None None None N None 0 0 None 0 0 None 0 0 2.00759E-05 0 0
D/A 22309 Ig-126 45 None 0.2725 None 0.09 N 0.405 0.196 0.301789629655 gnomAD-4.0.0 6.84466E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99701E-07 0 0
D/G 22309 Ig-126 45 rs1481781346 0.4163 None 0.324 N 0.317 0.194 0.288352970974 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/G 22309 Ig-126 45 rs1481781346 0.4163 None 0.324 N 0.317 0.194 0.288352970974 gnomAD-4.0.0 6.5754E-06 None None None None N None 2.4122E-05 0 None 0 0 None 0 0 0 0 0
D/H 22309 Ig-126 45 rs1204440058 0.3726 -0.812 0.928 N 0.375 0.208 0.347879110917 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66389E-04
D/H 22309 Ig-126 45 rs1204440058 0.3726 -0.812 0.928 N 0.375 0.208 0.347879110917 gnomAD-4.0.0 2.05342E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99705E-07 1.15961E-05 1.65772E-05
D/N 22309 Ig-126 45 rs1204440058 0.1656 None 0.324 N 0.365 0.165 0.254244900254 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/N 22309 Ig-126 45 rs1204440058 0.1656 None 0.324 N 0.365 0.165 0.254244900254 gnomAD-4.0.0 2.47987E-06 None None None None N None 4.0078E-05 0 None 0 0 None 0 0 8.47859E-07 0 0
D/V 22309 Ig-126 45 rs1481781346 0.2282 None 0.193 N 0.431 0.255 0.306695030598 gnomAD-4.0.0 4.10679E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39821E-06 0 0
S/R 22598 Ig-127 39 rs960274505 0.4393 -0.27 0.655 N 0.459 0.189 0.273503213844 gnomAD-2.1.1 1.61E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 2.67E-05 0
S/R 22598 Ig-127 39 rs960274505 0.4393 -0.27 0.655 N 0.459 0.189 0.273503213844 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
S/R 22598 Ig-127 39 rs960274505 0.4393 -0.27 0.655 N 0.459 0.189 0.273503213844 gnomAD-4.0.0 6.57497E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.06954E-04 0
S/T 22598 Ig-127 39 None 0.0679 None 0.007 N 0.197 0.064 0.250579442822 gnomAD-4.0.0 1.59194E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85976E-06 0 0
Q/P 22995 Ig-128 46 rs879410317 0.6317 0.372 0.662 N 0.307 0.359 0.446410834509 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
Q/P 22995 Ig-128 46 rs879410317 0.6317 0.372 0.662 N 0.307 0.359 0.446410834509 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.95E-05 0 0
Q/P 22995 Ig-128 46 rs879410317 0.6317 0.372 0.662 N 0.307 0.359 0.446410834509 gnomAD-4.0.0 4.96031E-06 None None None None N None 0 0 None 0 0 None 0 0 5.08688E-06 0 3.20359E-05
N/H 23390 Ig-129 46 None 0.0925 None None N 0.144 0.12 0.233150807113 gnomAD-4.0.0 1.59651E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87219E-06 0 0
N/S 23390 Ig-129 46 rs747202126 0.0724 0.142 0.005 N 0.164 0.13 0.163833314356 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/S 23390 Ig-129 46 rs747202126 0.0724 0.142 0.005 N 0.164 0.13 0.163833314356 gnomAD-4.0.0 2.05553E-06 None None None None N None 2.99204E-05 0 None 0 0 None 0 0 9.00844E-07 1.16025E-05 0
E/Q 24077 Ig-131 49 None 0.1782 None 1.0 N 0.555 0.3 0.357724736475 gnomAD-4.0.0 6.85309E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00782E-07 0 0
S/N 24474 Ig-132 44 None 0.0762 None 0.012 N 0.12 0.104 0.192905019026 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/K 24763 Ig-133 48 rs749832389 0.5042 0.024 0.067 N 0.314 0.083 0.104622674875 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
N/K 24763 Ig-133 48 rs749832389 0.5042 0.024 0.067 N 0.314 0.083 0.104622674875 gnomAD-4.0.0 1.59171E-06 None None None None N None 0 0 None 0 2.77408E-05 None 0 0 0 0 0
E/G 25159 Ig-134 49 None 0.3195 None 0.722 N 0.462 0.311 0.481246930725 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 25556 Ig-135 43 rs1707317089 0.0594 None 0.019 N 0.303 0.055 0.564872276104 gnomAD-4.0.0 6.846E-06 None None None None N None 0 2.23844E-05 None 0 0 None 0 0 8.09886E-06 0 0
E/G 26241 Ig-137 49 None 0.5125 None 0.988 N 0.649 0.496 0.469333501611 gnomAD-4.0.0 6.88882E-07 None None None None N None 0 0 None 0 0 None 0 0 9.02695E-07 0 0
Q/P 26638 Ig-138 45 rs540623797 0.5105 0.082 0.999 N 0.547 0.522 0.566047931302 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.88E-06 0
Q/P 26638 Ig-138 45 rs540623797 0.5105 0.082 0.999 N 0.547 0.522 0.566047931302 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06782E-04 0
Q/P 26638 Ig-138 45 rs540623797 0.5105 0.082 0.999 N 0.547 0.522 0.566047931302 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
Q/P 26638 Ig-138 45 rs540623797 0.5105 0.082 0.999 N 0.547 0.522 0.566047931302 gnomAD-4.0.0 2.05275E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79905E-06 1.15931E-05 0
E/G 27324 Ig-140 47 None 0.3039 None 1.0 N 0.761 0.468 0.539612970712 gnomAD-4.0.0 6.84216E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99475E-07 0 0
Q/H 27721 Ig-141 46 None 0.2277 None 0.999 N 0.588 0.411 0.497349015346 gnomAD-4.0.0 1.59152E-06 None None None None N None 0 0 None 0 2.7767E-05 None 0 0 0 0 0
Q/L 27721 Ig-141 46 None 0.1925 None 0.997 D 0.538 0.517 0.575880570741 gnomAD-4.0.0 1.59152E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85851E-06 0 0
E/V 28405 Ig-143 48 None 0.2599 None 0.988 N 0.785 0.471 0.693353280975 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Y/S 28800 Ig-144 46 None 0.0561 None None N 0.156 0.201 0.370240404367 gnomAD-4.0.0 1.38188E-06 None None None None N None 0 0 None 0 0 None 0 0 9.05581E-07 1.19574E-05 0
C/S 29488 Ig-146 45 None 0.0914 None None N 0.163 0.229 0.538421760271 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/G 29887 Ig-147 46 None 0.0956 None 0.012 N 0.281 0.12 0.266843984389 gnomAD-4.0.0 1.59251E-06 None None None None N None 0 0 None 0 2.77285E-05 None 0 0 0 0 0
R/C 30179 Ig-148 48 rs769360937 0.2666 -0.573 1.0 N 0.745 0.428 0.731906779097 gnomAD-2.1.1 3.77E-05 None None None None N None 4.16E-05 2.97E-05 None 0 5.21E-05 None 1.91791E-04 None 0 1.63E-05 0
R/C 30179 Ig-148 48 rs769360937 0.2666 -0.573 1.0 N 0.745 0.428 0.731906779097 gnomAD-3.1.2 3.29E-05 None None None None N None 7.24E-05 0 0 0 1.9305E-04 None 0 0 1.47E-05 0 0
R/C 30179 Ig-148 48 rs769360937 0.2666 -0.573 1.0 N 0.745 0.428 0.731906779097 gnomAD-4.0.0 3.26224E-05 None None None None N None 6.72676E-05 1.71562E-05 None 0 2.24406E-05 None 0 0 1.11161E-05 3.4391E-04 3.24971E-05
R/G 30179 Ig-148 48 rs769360937 0.5846 -0.955 1.0 N 0.593 0.376 0.672020861447 gnomAD-2.1.1 4.28E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.33E-06 0
R/G 30179 Ig-148 48 rs769360937 0.5846 -0.955 1.0 N 0.593 0.376 0.672020861447 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/G 30179 Ig-148 48 rs769360937 0.5846 -0.955 1.0 N 0.593 0.376 0.672020861447 gnomAD-4.0.0 2.3212E-05 None None None None N None 0 0 None 0 0 None 0 0 3.07831E-05 0 1.62485E-05
R/H 30179 Ig-148 48 rs149567378 0.1482 -1.163 1.0 N 0.753 0.403 None gnomAD-2.1.1 3.2551E-03 None None None None N None 2.08247E-04 9.01605E-04 None 1.15128E-03 1.04515E-04 None 2.2189E-02 None 4.2E-05 1.83667E-03 2.98954E-03
R/H 30179 Ig-148 48 rs149567378 0.1482 -1.163 1.0 N 0.753 0.403 None gnomAD-3.1.2 1.8407E-03 None None None None N None 2.41348E-04 1.83582E-03 0 8.64055E-04 1.9305E-04 None 0 0 1.74933E-03 2.38391E-02 1.91388E-03
R/H 30179 Ig-148 48 rs149567378 0.1482 -1.163 1.0 N 0.753 0.403 None 1000 genomes 6.1901E-03 None None None None N None 0 1.4E-03 None None 0 2E-03 None None None 2.86E-02 None
R/H 30179 Ig-148 48 rs149567378 0.1482 -1.163 1.0 N 0.753 0.403 None gnomAD-4.0.0 2.16914E-03 None None None None N None 3.09131E-04 1.08508E-03 None 8.47218E-04 2.01975E-04 None 4.74533E-05 4.19463E-03 1.09666E-03 2.12205E-02 2.97542E-03
R/P 30179 Ig-148 48 rs149567378 0.9489 -0.334 1.0 D 0.703 0.488 0.593515057505 gnomAD-2.1.1 4.32E-06 None None None None N None 0 3.08E-05 None 0 0 None 0 None 0 0 0
R/P 30179 Ig-148 48 rs149567378 0.9489 -0.334 1.0 D 0.703 0.488 0.593515057505 gnomAD-4.0.0 1.38834E-06 None None None None N None 3.04451E-05 2.3371E-05 None 0 0 None 0 0 0 0 0
E/V 30574 Ig-149 43 rs1308285808 0.3766 -0.127 1.0 N 0.759 0.488 0.62634362422 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.65508E-04
E/V 30574 Ig-149 43 rs1308285808 0.3766 -0.127 1.0 N 0.759 0.488 0.62634362422 gnomAD-4.0.0 2.05259E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 4.96936E-05
S/C 31263 Ig-151 46 rs1482369519 0.0916 -0.323 0.002 D 0.267 0.128 0.338834610459 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
S/C 31263 Ig-151 46 rs1482369519 0.0916 -0.323 0.002 D 0.267 0.128 0.338834610459 gnomAD-4.0.0 4.77328E-06 None None None None N None 0 0 None 0 2.77408E-05 None 0 0 5.71562E-06 0 0
I/S 32060 Ig-153 44 None 0.2813 None 0.784 N 0.397 0.248 0.698813973971 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 32354 Ig-154 48 None 0.1283 None 0.966 N 0.355 0.206 0.490006198212 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
M/I 32750 Ig-155 43 None 0.5212 None 0.985 N 0.535 0.349 0.723745936845 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
M/V 32750 Ig-155 43 rs771143872 0.1247 0.15 0.985 N 0.47 0.397 0.709758000367 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
M/V 32750 Ig-155 43 rs771143872 0.1247 0.15 0.985 N 0.47 0.397 0.709758000367 gnomAD-4.0.0 5.47356E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19577E-06 0 0
K/N 33148 Ig-156 48 None 0.648 None 1.0 D 0.679 0.39 0.225215365344 gnomAD-4.0.0 1.59135E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85843E-06 0 0
T/I 33244 Ig-157 42 rs1282327572 0.1418 -0.185 0.006 N 0.185 0.209 0.270447802918 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 0 0
T/N 33244 Ig-157 42 None 0.1372 None 0.639 N 0.373 0.191 0.27855597813 gnomAD-4.0.0 1.59177E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85896E-06 0 0
R/S 33544 Ig-158 49 None 0.8288 None 0.522 N 0.475 0.231 0.27855597813 gnomAD-4.0.0 6.84408E-07 None None None None I None 0 0 None 0 0 None 0 1.73551E-04 0 0 0
Q/K 33643 Ig-159 48 None 0.5193 None 0.998 N 0.409 0.391 0.335414705075 gnomAD-4.0.0 1.5913E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
E/A 34184 Ig-160 48 rs920777916 0.2952 -0.595 0.999 N 0.655 0.62 0.499535901811 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/A 34184 Ig-160 48 rs920777916 0.2952 -0.595 0.999 N 0.655 0.62 0.499535901811 gnomAD-4.0.0 1.59101E-06 None None None None N None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
E/K 34184 Ig-160 48 rs776306284 0.2093 0.023 1.0 N 0.581 0.403 0.374076547971 gnomAD-2.1.1 3.21E-05 None None None None N None 4.13E-05 0 None 0 0 None 9.8E-05 None 1.59847E-04 0 1.40213E-04
E/K 34184 Ig-160 48 rs776306284 0.2093 0.023 1.0 N 0.581 0.403 0.374076547971 gnomAD-3.1.2 5.26E-05 None None None None N None 0 0 0 0 0 None 6.59506E-04 0 1.47E-05 0 0
E/K 34184 Ig-160 48 rs776306284 0.2093 0.023 1.0 N 0.581 0.403 0.374076547971 gnomAD-4.0.0 1.73502E-05 None None None None N None 0 1.6665E-05 None 0 0 None 2.34324E-04 0 4.23781E-06 7.68572E-05 0
T/I 34308 Ig-161 51 rs528711725 0.0777 0.115 0.001 N 0.262 0.146 0.117506650769 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.6715E-04 None 0 None 0 0 0
T/I 34308 Ig-161 51 rs528711725 0.0777 0.115 0.001 N 0.262 0.146 0.117506650769 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92382E-04 None 0 0 0 0 0
T/I 34308 Ig-161 51 rs528711725 0.0777 0.115 0.001 N 0.262 0.146 0.117506650769 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
T/I 34308 Ig-161 51 rs528711725 0.0777 0.115 0.001 N 0.262 0.146 0.117506650769 gnomAD-4.0.0 3.84214E-06 None None None None N None 0 0 None 0 7.27273E-05 None 0 0 0 0 0
T/P 34308 Ig-161 51 rs769739303 0.5602 -0.532 0.484 N 0.44 0.189 0.337621943819 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 2.22866E-04 None 0 None 0 0 0
T/P 34308 Ig-161 51 rs769739303 0.5602 -0.532 0.484 N 0.44 0.189 0.337621943819 gnomAD-4.0.0 1.90927E-05 None None None None N None 0 0 None 0 3.32742E-04 None 0 0 0 0 0
H/R 34989 Ig-163 48 rs1187175097 0.0788 -0.931 None N 0.105 0.097 0.107399877778 gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
H/R 34989 Ig-163 48 rs1187175097 0.0788 -0.931 None N 0.105 0.097 0.107399877778 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
H/R 34989 Ig-163 48 rs1187175097 0.0788 -0.931 None N 0.105 0.097 0.107399877778 gnomAD-4.0.0 5.57655E-06 None None None None N None 0 0 None 0 0 None 0 0 6.78034E-06 0 1.60087E-05
Q/L 35176 Ig-164 48 None 0.1583 None None N 0.213 0.198 0.355450299083 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/H 35333 Ig-165 48 rs764231632 0.2348 None 0.975 N 0.39 0.236 0.399596177874 gnomAD-4.0.0 8.8938E-06 None None None None N None 0 0 None 0 0 None 0 0 1.07927E-05 0 1.6564E-05
R/G 35652 Ig-167 46 rs565675340 0.4647 -1.547 0.922 N 0.527 0.385 0.403609169532 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 4.66E-05 0 0
R/G 35652 Ig-167 46 rs565675340 0.4647 -1.547 0.922 N 0.527 0.385 0.403609169532 gnomAD-4.0.0 1.369E-06 None None None None N None 0 0 None 0 0 None 1.87427E-05 0 0 0 1.65739E-05
R/Q 35652 Ig-167 46 rs200497615 0.1473 -0.477 0.447 N 0.315 0.111 None gnomAD-2.1.1 1.64394E-04 None None None None N None 4.14E-05 5.68E-05 None 9.7E-05 0 None 2.94831E-04 None 0 2.57708E-04 0
R/Q 35652 Ig-167 46 rs200497615 0.1473 -0.477 0.447 N 0.315 0.111 None gnomAD-3.1.2 1.70862E-04 None None None None N None 1.20645E-04 6.54E-05 0 0 0 None 0 0 2.93971E-04 0 0
R/Q 35652 Ig-167 46 rs200497615 0.1473 -0.477 0.447 N 0.315 0.111 None gnomAD-4.0.0 3.97383E-04 None None None None N None 9.3438E-05 6.67134E-05 None 3.38135E-05 0 None 1.56353E-05 1.64528E-04 5.03684E-04 2.85582E-04 1.12122E-04
H/P 35946 Ig-169 50 rs281864931 0.7767 -0.76 0.998 D 0.721 0.628 0.531873083431 Pollazzon (2010) Rudloff (2015) None TMD LGMD2J het None -1.036(OBSL1) -0.709(OBSCN) N Genetic analysis of TTN in single 3-generation ITA family; co-segregates with disease (n = 5, 5 affected (total 7)); Domain unfolds at body temperature; eliminates binding to OBSCN-Ig1; low expression; monomeric None None None None None None None None None None None
H/Y 35946 Ig-169 50 rs1686745897 0.1638 None 0.993 N 0.442 0.424 0.4744847356 gnomAD-4.0.0 1.36828E-06 None None None -0.435(OBSL1) -0.23(OBSCN) N None 0 0 None 0 0 None 0 0 0 2.31868E-05 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.