Structural position:

  • Domain Type: Ig
  • Aligned Position: 135
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand E

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
R/C 62 Ig-1 57 rs766108359 0.2379 -0.905 1.0 D 0.741 0.561 0.789176987369 gnomAD-2.1.1 1.19E-05 None None None -0.054(TCAP) N None 0 0 None 0 0 None 0 None 0 2.64E-05 0
R/C 62 Ig-1 57 rs766108359 0.2379 -0.905 1.0 D 0.741 0.561 0.789176987369 gnomAD-4.0.0 4.10443E-06 None None None -0.054(TCAP) N None 0 0 None 3.82614E-05 0 None 0 0 2.69789E-06 2.31863E-05 0
R/G 62 Ig-1 57 None 0.3654 None 1.0 N 0.69 0.621 0.690662525078 gnomAD-4.0.0 6.84071E-07 None None None -0.371(TCAP) N None 0 0 None 0 0 None 0 0 8.99295E-07 0 0
R/H 62 Ig-1 57 rs758169489 0.0838 -1.574 1.0 N 0.748 0.499 None gnomAD-2.1.1 7.78E-05 None None None 0.037(TCAP) N None 4.01E-05 0 None 0 8.53328E-04 None 9.8E-05 None 0 7.75E-06 0
R/H 62 Ig-1 57 rs758169489 0.0838 -1.574 1.0 N 0.748 0.499 None gnomAD-3.1.2 3.95E-05 None None None 0.037(TCAP) N None 4.83E-05 0 0 0 3.86698E-04 None 0 0 2.94E-05 0 0
R/H 62 Ig-1 57 rs758169489 0.0838 -1.574 1.0 N 0.748 0.499 None gnomAD-4.0.0 1.85888E-05 None None None 0.037(TCAP) N None 2.67173E-05 0 None 0 3.1211E-04 None 0 0 8.47455E-06 3.29366E-05 1.60036E-05
L/F 158 Ig-2 55 rs1490704308 0.2249 -1.503 0.374 N 0.306 0.236 0.479208069955 gnomAD-2.1.1 3.18E-05 None None None -0.319(TCAP) N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
L/F 158 Ig-2 55 rs1490704308 0.2249 -1.503 0.374 N 0.306 0.236 0.479208069955 gnomAD-3.1.2 6.57E-06 None None None -0.319(TCAP) N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/F 158 Ig-2 55 rs1490704308 0.2249 -1.503 0.374 N 0.306 0.236 0.479208069955 gnomAD-4.0.0 1.85869E-06 None None None -0.319(TCAP) N None 0 0 None 0 0 None 0 0 2.54231E-06 0 0
L/V 158 Ig-2 55 None 0.1061 None 0.097 N 0.343 0.232 0.393159880135 gnomAD-4.0.0 6.84056E-07 None None None -0.384(TCAP) N None 0 0 None 0 0 None 0 0 8.9929E-07 0 0
I/V 997 Ig-3 55 rs761499989 0.0903 -1.217 0.001 N 0.118 0.063 0.518531843619 gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 1.77E-05 0
I/V 997 Ig-3 55 rs761499989 0.0903 -1.217 0.001 N 0.118 0.063 0.518531843619 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 997 Ig-3 55 rs761499989 0.0903 -1.217 0.001 N 0.118 0.063 0.518531843619 gnomAD-4.0.0 6.403E-06 None None None None N None 0 0 None 0 0 None 0 0 7.17521E-06 2.67996E-05 0
E/D 1138 Ig-4 57 rs777365068 0.1861 -0.743 0.046 N 0.365 0.128 0.130388298395 gnomAD-2.1.1 3.98E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/D 1138 Ig-4 57 rs777365068 0.1861 -0.743 0.046 N 0.365 0.128 0.130388298395 gnomAD-4.0.0 2.05237E-06 None None None None I None 0 0 None 0 0 None 0 0 0 3.47802E-05 0
E/G 1138 Ig-4 57 rs749125389 0.4098 -0.351 0.939 N 0.687 0.584 0.522822360876 gnomAD-2.1.1 1.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.64E-05 0
E/G 1138 Ig-4 57 rs749125389 0.4098 -0.351 0.939 N 0.687 0.584 0.522822360876 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 1138 Ig-4 57 rs749125389 0.4098 -0.351 0.939 N 0.687 0.584 0.522822360876 gnomAD-4.0.0 3.71756E-06 None None None None I None 0 0 None 0 0 None 0 0 3.38988E-06 0 3.20102E-05
T/A 1512 Ig-6 56 None 0.27 None 0.996 N 0.473 0.364 0.381916209588 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
T/I 1512 Ig-6 56 rs375794484 0.3084 -0.219 0.992 N 0.598 0.483 None gnomAD-2.1.1 1.6E-05 None None None None I None 2.46214E-04 0 None 0 0 None 0 None 0 0 0
T/I 1512 Ig-6 56 rs375794484 0.3084 -0.219 0.992 N 0.598 0.483 None gnomAD-3.1.2 3.29E-05 None None None None I None 1.20662E-04 0 0 0 0 None 0 0 0 0 0
T/I 1512 Ig-6 56 rs375794484 0.3084 -0.219 0.992 N 0.598 0.483 None 1000 genomes 3.99361E-04 None None None None I None 1.5E-03 0 None None 0 0 None None None 0 None
T/I 1512 Ig-6 56 rs375794484 0.3084 -0.219 0.992 N 0.598 0.483 None gnomAD-4.0.0 7.68456E-06 None None None None I None 1.01286E-04 0 None 0 0 None 0 0 0 0 0
T/P 1512 Ig-6 56 None 0.8579 None 1.0 D 0.773 0.585 0.498065138572 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 1612 Ig-7 57 rs1445985420 0.26 0.259 0.062 N 0.448 0.339 0.226586394389 gnomAD-2.1.1 1.2E-05 None None None None N None 0 8.68E-05 None 0 0 None 0 None 0 0 0
E/K 1612 Ig-7 57 rs1445985420 0.26 0.259 0.062 N 0.448 0.339 0.226586394389 gnomAD-3.1.2 7.88E-05 None None None None N None 0 7.85443E-04 0 0 0 None 0 0 0 0 0
E/K 1612 Ig-7 57 rs1445985420 0.26 0.259 0.062 N 0.448 0.339 0.226586394389 gnomAD-4.0.0 2.17728E-05 None None None None N None 0 2.88116E-04 None 0 0 None 0 0 0 0 0
I/V 1894 Ig-9 54 rs751529942 0.2662 -1.212 0.993 N 0.338 0.292 0.664580999671 gnomAD-2.1.1 7.97E-06 None None None None N None 0 0 None 0 0 None 6.53E-05 None 0 0 0
I/V 1894 Ig-9 54 rs751529942 0.2662 -1.212 0.993 N 0.338 0.292 0.664580999671 gnomAD-4.0.0 6.36215E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.73082E-05 0
V/I 2133 Ig-10 56 None 0.0927 None 0.997 N 0.521 0.272 0.615660705115 gnomAD-4.0.0 1.59071E-06 None None None None N None 0 0 None 0 2.77608E-05 None 0 0 0 0 0
V/A 2228 Ig-11 55 rs752706070 0.3224 -1.829 0.011 N 0.238 0.168 0.524063890018 gnomAD-2.1.1 7.96E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.76E-05 0
V/A 2228 Ig-11 55 rs752706070 0.3224 -1.829 0.011 N 0.238 0.168 0.524063890018 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
V/A 2228 Ig-11 55 rs752706070 0.3224 -1.829 0.011 N 0.238 0.168 0.524063890018 gnomAD-4.0.0 4.95711E-06 None None None None N None 0 0 None 0 0 None 0 0 6.77999E-06 0 0
V/F 2228 Ig-11 55 None 0.3621 None 0.968 N 0.726 0.305 0.839479631173 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
V/G 2228 Ig-11 55 None 0.2503 None 0.811 N 0.696 0.35 0.83007336595 gnomAD-4.0.0 6.84139E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99339E-07 0 0
V/I 2228 Ig-11 55 None 0.1173 None 0.026 N 0.357 0.092 0.530754069387 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/C 2320 Ig-12 54 rs776478343 0.2522 -0.649 1.0 N 0.737 0.529 None gnomAD-2.1.1 2.79E-05 None None None None N None 0 2.89E-05 None 0 0 None 1.30659E-04 None 0 1.77E-05 0
R/C 2320 Ig-12 54 rs776478343 0.2522 -0.649 1.0 N 0.737 0.529 None gnomAD-3.1.2 3.29E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 2.94E-05 0 0
R/C 2320 Ig-12 54 rs776478343 0.2522 -0.649 1.0 N 0.737 0.529 None gnomAD-4.0.0 3.09808E-05 None None None None N None 1.33543E-04 3.33433E-05 None 0 2.22757E-05 None 0 0 1.35597E-05 2.08599E-04 3.20092E-05
R/G 2320 Ig-12 54 None 0.6304 None 1.0 N 0.705 0.57 0.726536768148 gnomAD-4.0.0 6.84089E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99329E-07 0 0
R/H 2320 Ig-12 54 rs374615369 0.1323 -1.285 1.0 N 0.72 0.568 None gnomAD-2.1.1 7.44E-05 None None None None N None 1.20173E-04 0 None 0 0 None 0 None 0 1.39825E-04 0
R/H 2320 Ig-12 54 rs374615369 0.1323 -1.285 1.0 N 0.72 0.568 None gnomAD-3.1.2 7.89E-05 None None None None N None 9.66E-05 6.55E-05 0 0 0 None 0 0 1.0289E-04 0 0
R/H 2320 Ig-12 54 rs374615369 0.1323 -1.285 1.0 N 0.72 0.568 None gnomAD-4.0.0 8.54974E-05 None None None None N None 1.06644E-04 1.66628E-05 None 0 0 None 0 3.29924E-04 1.05935E-04 0 3.19959E-05
S/C 2409 Ig-13 54 rs769246937 0.1345 -0.353 0.999 N 0.523 0.41 0.546995609267 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
S/C 2409 Ig-13 54 rs769246937 0.1345 -0.353 0.999 N 0.523 0.41 0.546995609267 gnomAD-4.0.0 6.84073E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99305E-07 0 0
S/Y 2409 Ig-13 54 rs769246937 0.3242 -0.156 0.996 N 0.606 0.435 0.70524541446 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
S/Y 2409 Ig-13 54 rs769246937 0.3242 -0.156 0.996 N 0.606 0.435 0.70524541446 gnomAD-4.0.0 6.84073E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99305E-06 0 0
K/N 2499 Ig-14 55 rs769774709 0.9018 -0.571 1.0 D 0.723 0.292 0.21279746466 gnomAD-2.1.1 1.19E-05 None None None None N None 0 0 None 0 0 None 9.8E-05 None 0 0 0
K/N 2499 Ig-14 55 rs769774709 0.9018 -0.571 1.0 D 0.723 0.292 0.21279746466 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
K/N 2499 Ig-14 55 rs769774709 0.9018 -0.571 1.0 D 0.723 0.292 0.21279746466 gnomAD-4.0.0 6.81563E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.09786E-04 1.60041E-05
I/L 2586 Ig-15 54 None 0.149 None 0.509 N 0.263 0.239 0.512424132817 gnomAD-4.0.0 1.59126E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43349E-05 0
I/M 2586 Ig-15 54 rs556000493 0.1191 -0.862 0.988 N 0.512 0.26 None gnomAD-2.1.1 2.95773E-04 None None None None N None 0 0 None 0 0 None 2.38734E-03 None 0 8.84E-06 0
I/M 2586 Ig-15 54 rs556000493 0.1191 -0.862 0.988 N 0.512 0.26 None gnomAD-3.1.2 5.91E-05 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 1.657E-03 0
I/M 2586 Ig-15 54 rs556000493 0.1191 -0.862 0.988 N 0.512 0.26 None 1000 genomes 7.98722E-04 None None None None N None 0 0 None None 0 0 None None None 4.1E-03 None
I/M 2586 Ig-15 54 rs556000493 0.1191 -0.862 0.988 N 0.512 0.26 None gnomAD-4.0.0 1.25169E-04 None None None None N None 0 0 None 0 0 None 0 0 6.78022E-06 2.0319E-03 1.44028E-04
I/V 2586 Ig-15 54 rs2091789026 0.0961 None 0.061 N 0.119 0.139 0.490352026379 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 2586 Ig-15 54 rs2091789026 0.0961 None 0.061 N 0.119 0.139 0.490352026379 gnomAD-4.0.0 6.57091E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4699E-05 0 0
K/Q 2673 Ig-16 53 None 0.1543 None 0.996 N 0.505 0.318 0.267755039894 gnomAD-4.0.0 1.59058E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85656E-06 0 0
K/R 2673 Ig-16 53 rs1060500389 0.0925 -0.577 0.986 N 0.45 0.249 0.311691414656 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 6.41849E-04 None 0 None 0 0 0
K/R 2673 Ig-16 53 rs1060500389 0.0925 -0.577 0.986 N 0.45 0.249 0.311691414656 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92827E-04 None 0 0 0 0 0
K/R 2673 Ig-16 53 rs1060500389 0.0925 -0.577 0.986 N 0.45 0.249 0.311691414656 gnomAD-4.0.0 6.57125E-06 None None None None N None 0 0 None 0 1.92827E-04 None 0 0 0 0 0
I/V 2761 Ig-17 55 None 0.0557 None None N 0.1 0.23 0.159798565429 gnomAD-4.0.0 4.10441E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39577E-06 0 0
V/L 2848 Ig-18 54 None 0.4364 None 0.835 N 0.498 0.231 0.454987352986 gnomAD-4.0.0 1.59046E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02133E-05
T/I 3022 Ig-20 54 None 0.2332 None 0.991 N 0.803 0.684 0.570301176191 gnomAD-4.0.0 1.36817E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79859E-06 0 0
T/P 3022 Ig-20 54 None 0.8484 None 0.991 D 0.803 0.636 0.578230335649 gnomAD-4.0.0 3.60396E-06 None None None None N None 0 0 None 0 0 None 0 0 3.94085E-06 0 0
V/I 3111 Ig-21 54 rs2090778418 0.0793 None 0.987 N 0.523 0.202 0.639788913552 gnomAD-4.0.0 3.18123E-06 None None None None N None 0 0 None 0 5.55124E-05 None 0 0 0 0 0
I/M 3202 Ig-22 56 None 0.2813 None 0.934 N 0.488 0.346 0.576839456108 gnomAD-4.0.0 1.59055E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85656E-06 0 0
E/D 3293 Ig-23 55 rs4894043 0.4342 None 0.989 N 0.485 0.327 0.330331372229 gnomAD-4.0.0 6.84068E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65579E-05
E/Q 3293 Ig-23 55 rs2090028411 0.2198 None 0.889 N 0.31 0.257 0.291694819147 gnomAD-4.0.0 2.73628E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59718E-06 0 0
T/A 3398 Ig-24 54 rs2088221144 0.11 None 0.704 N 0.395 0.554 0.346768085243 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
T/A 3398 Ig-24 54 rs2088221144 0.11 None 0.704 N 0.395 0.554 0.346768085243 gnomAD-4.0.0 6.5697E-06 None None None None N None 0 6.54536E-05 None 0 0 None 0 0 0 0 0
I/T 3714 Ig-26 55 None 0.1379 None None None None 0.159 None gnomAD-4.0.0 1.59118E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
S/P 3993 Ig-28 56 rs771077873 0.7145 0.335 0.896 D 0.525 0.253 None gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/P 3993 Ig-28 56 rs771077873 0.7145 0.335 0.896 D 0.525 0.253 None gnomAD-4.0.0 3.18292E-06 None None None None I None 0 2.28655E-05 None 0 0 None 0 0 0 0 3.02425E-05
T/I 4658 Ig-29 53 rs758799742 0.1252 0.12 0.007 N 0.321 0.126 None gnomAD-2.1.1 1.22E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
T/I 4658 Ig-29 53 rs758799742 0.1252 0.12 0.007 N 0.321 0.126 None gnomAD-4.0.0 5.49212E-06 None None None None N None 0 2.24507E-05 None 0 0 None 0 0 6.31641E-06 0 0
T/K 4658 Ig-29 53 rs758799742 0.1503 None 0.782 N 0.585 0.242 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
T/K 4658 Ig-29 53 rs758799742 0.1503 None 0.782 N 0.585 0.242 None gnomAD-4.0.0 6.56771E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07297E-04 0
I/N 4754 Ig-30 55 rs1012186680 0.1477 None 0.033 N 0.605 0.199 0.717156073737 gnomAD-4.0.0 6.84252E-07 None None None None N None 0 0 None 0 0 None 0 1.7343E-04 0 0 0
I/T 4754 Ig-30 55 None 0.1001 None None N 0.167 0.173 0.612396071159 gnomAD-4.0.0 6.84252E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15942E-05 0
I/T 4942 Ig-32 55 rs773235984 0.0824 -1.308 0.549 N 0.525 0.307 0.603169182973 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
I/T 4942 Ig-32 55 rs773235984 0.0824 -1.308 0.549 N 0.525 0.307 0.603169182973 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/T 4942 Ig-32 55 rs773235984 0.0824 -1.308 0.549 N 0.525 0.307 0.603169182973 gnomAD-4.0.0 3.84408E-06 None None None None N None 3.38215E-05 0 None 0 2.42825E-05 None 0 0 0 0 0
E/G 5036 Ig-33 56 None 0.5753 None 0.642 N 0.513 0.255 0.343788945184 gnomAD-4.0.0 1.59127E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8583E-06 0 0
E/K 5036 Ig-33 56 rs1353528713 0.3396 -1.02 0.473 N 0.327 0.245 0.263140351381 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 9.95E-05 0 None 0 None 0 0 0
E/K 5036 Ig-33 56 rs1353528713 0.3396 -1.02 0.473 N 0.327 0.245 0.263140351381 gnomAD-4.0.0 1.59131E-06 None None None None N None 0 0 None 4.76735E-05 0 None 0 0 0 0 0
L/I 5129 Ig-34 55 None 0.0549 None None N 0.194 0.125 0.190952846119 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
V/I 5315 Ig-36 55 None 0.0652 None None N 0.151 0.089 0.336647302497 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 5411 Ig-37 55 rs757542282 0.1694 -0.135 0.669 N 0.525 0.312 0.53782465974 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
T/I 5411 Ig-37 55 rs757542282 0.1694 -0.135 0.669 N 0.525 0.312 0.53782465974 gnomAD-4.0.0 1.36862E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79899E-06 0 0
T/P 5411 Ig-37 55 None 0.4739 None 0.966 D 0.549 0.451 0.586114214298 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
E/D 5504 Ig-38 55 None 0.172 None 0.625 N 0.423 0.102 0.247872288689 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/G 5504 Ig-38 55 rs1038822352 0.1343 None 0.454 N 0.565 0.275 0.391470661076 gnomAD-4.0.0 6.84267E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99496E-07 0 0
E/K 5504 Ig-38 55 rs2080741049 0.1416 None 0.801 N 0.434 0.25 0.252162846088 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.43E-05 0 0 0 0
E/K 5504 Ig-38 55 rs2080741049 0.1416 None 0.801 N 0.434 0.25 0.252162846088 gnomAD-4.0.0 6.57315E-06 None None None None N None 0 0 None 0 0 None 9.42507E-05 0 0 0 0
E/Q 5504 Ig-38 55 None 0.1026 None 0.891 N 0.463 0.222 0.208000267992 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/V 5504 Ig-38 55 rs1038822352 0.1613 -0.05 0.669 N 0.599 0.315 0.508223314113 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
E/V 5504 Ig-38 55 rs1038822352 0.1613 -0.05 0.669 N 0.599 0.315 0.508223314113 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
E/V 5504 Ig-38 55 rs1038822352 0.1613 -0.05 0.669 N 0.599 0.315 0.508223314113 gnomAD-4.0.0 4.95802E-06 None None None None N None 9.34405E-05 0 None 0 0 None 0 0 0 0 1.60143E-05
T/A 5598 Ig-39 56 rs1407842307 0.0772 -1.188 None N 0.088 0.154 0.0806252709748 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/A 5598 Ig-39 56 rs1407842307 0.0772 -1.188 None N 0.088 0.154 0.0806252709748 gnomAD-4.0.0 1.36841E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79894E-06 0 0
L/P 5691 Ig-40 55 None 0.5861 None 0.896 N 0.653 0.374 0.797747263677 gnomAD-4.0.0 1.59122E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8583E-06 0 0
V/M 5784 Ig-41 55 rs2080478470 0.1042 None 0.934 D 0.517 0.195 0.502254315933 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/M 5784 Ig-41 55 rs2080478470 0.1042 None 0.934 D 0.517 0.195 0.502254315933 gnomAD-4.0.0 6.57324E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47042E-05 0 0
V/A 5877 Ig-42 55 None 0.1857 None 0.454 N 0.378 0.138 0.59634542923 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 5973 Ig-43 55 rs765275978 0.2028 0.126 0.012 N 0.245 0.197 0.302459207581 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
T/I 5973 Ig-43 55 rs765275978 0.2028 0.126 0.012 N 0.245 0.197 0.302459207581 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 5973 Ig-43 55 rs765275978 0.2028 0.126 0.012 N 0.245 0.197 0.302459207581 gnomAD-4.0.0 6.57428E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47016E-05 0 0
T/P 5973 Ig-43 55 None 0.8831 None 0.966 N 0.569 0.458 0.492475246742 gnomAD-4.0.0 1.59154E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85899E-06 0 0
T/S 5973 Ig-43 55 None 0.2315 None 0.669 N 0.439 0.175 0.257786959452 gnomAD-4.0.0 1.59154E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
S/C 6066 Ig-44 55 rs762434229 0.139 None 1.0 N 0.729 0.429 0.638815175438 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/C 6066 Ig-44 55 rs762434229 0.139 None 1.0 N 0.729 0.429 0.638815175438 gnomAD-4.0.0 1.85947E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54311E-06 0 0
S/F 6066 Ig-44 55 rs762434229 0.1747 -0.982 0.998 N 0.745 0.426 0.768949010136 gnomAD-2.1.1 3.22E-05 None None None None N None 0 2.03465E-04 None 0 5.6E-05 None 0 None 0 0 0
S/F 6066 Ig-44 55 rs762434229 0.1747 -0.982 0.998 N 0.745 0.426 0.768949010136 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.31027E-04 0 0 0 None 0 0 0 0 0
S/F 6066 Ig-44 55 rs762434229 0.1747 -0.982 0.998 N 0.745 0.426 0.768949010136 gnomAD-4.0.0 6.19824E-06 None None None None N None 0 1.50175E-04 None 0 0 None 0 0 0 0 1.60179E-05
V/G 6253 Ig-46 55 rs1236936612 0.1601 -2.527 0.642 N 0.651 0.32 0.8362503026 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/G 6253 Ig-46 55 rs1236936612 0.1601 -2.527 0.642 N 0.651 0.32 0.8362503026 gnomAD-4.0.0 1.59159E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
V/L 6253 Ig-46 55 rs754852812 0.1146 None 0.002 N 0.183 0.104 0.462200489575 gnomAD-4.0.0 2.25809E-05 None None None None N None 0 0 None 0 0 None 0 0 2.87855E-05 0 1.65678E-05
V/M 6346 Ig-47 55 rs537966944 0.0908 -0.602 0.942 D 0.641 0.313 None gnomAD-2.1.1 2.51E-05 None None None None N None 8.29E-05 0 None 0 0 None 0 None 0 3.94E-05 0
V/M 6346 Ig-47 55 rs537966944 0.0908 -0.602 0.942 D 0.641 0.313 None gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
V/M 6346 Ig-47 55 rs537966944 0.0908 -0.602 0.942 D 0.641 0.313 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
V/M 6346 Ig-47 55 rs537966944 0.0908 -0.602 0.942 D 0.641 0.313 None gnomAD-4.0.0 3.40967E-05 None None None None N None 3.99936E-05 0 None 0 0 None 0 0 4.40866E-05 0 0
V/M 6439 Ig-48 55 rs727505289 0.173 -0.501 0.953 N 0.582 0.254 0.444305618086 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 1.1212E-04 None 0 None 0 1.78E-05 0
V/M 6439 Ig-48 55 rs727505289 0.173 -0.501 0.953 N 0.582 0.254 0.444305618086 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/M 6439 Ig-48 55 rs727505289 0.173 -0.501 0.953 N 0.582 0.254 0.444305618086 gnomAD-4.0.0 1.42585E-05 None None None None N None 0 0 None 0 2.45733E-04 None 0 0 8.47785E-06 1.0982E-05 1.60226E-05
S/T 6535 Ig-49 55 None 0.0536 None None N 0.133 0.106 0.101711395817 gnomAD-4.0.0 6.84502E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99735E-07 0 0
T/P 6628 Ig-50 55 None 0.2892 None 0.937 D 0.607 0.507 0.476754456241 gnomAD-4.0.0 6.00161E-06 None None None None N None 0 0 None 0 0 None 0 0 6.56251E-06 0 0
H/Y 6815 Ig-52 55 None 0.0912 None 0.473 N 0.285 0.105 0.214338557667 gnomAD-4.0.0 1.5927E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02828E-05
V/D 6909 Ig-53 56 rs1316718244 0.3046 None 0.193 D 0.611 0.282 0.716185225888 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/D 6909 Ig-53 56 rs1316718244 0.3046 None 0.193 D 0.611 0.282 0.716185225888 gnomAD-4.0.0 6.57255E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4705E-05 0 0
I/L 7002 Ig-54 55 rs2078973512 0.1595 None 0.005 N 0.249 0.049 0.290962096972 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/L 7002 Ig-54 55 rs2078973512 0.1595 None 0.005 N 0.249 0.049 0.290962096972 gnomAD-4.0.0 6.57402E-06 None None None None N None 2.41301E-05 0 None 0 0 None 0 0 0 0 0
I/M 7002 Ig-54 55 rs759813012 0.1332 -0.559 0.171 N 0.463 0.056 0.458374381611 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
I/M 7002 Ig-54 55 rs759813012 0.1332 -0.559 0.171 N 0.463 0.056 0.458374381611 gnomAD-4.0.0 1.36865E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79919E-06 0 0
V/I 7098 Ig-55 55 rs878978917 0.0653 -0.699 0.003 N 0.311 0.118 0.496099317193 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
V/I 7098 Ig-55 55 rs878978917 0.0653 -0.699 0.003 N 0.311 0.118 0.496099317193 gnomAD-4.0.0 2.73726E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59838E-06 0 0
V/M 7191 Ig-56 55 rs1338451033 0.1072 None 0.934 D 0.497 0.274 0.389439708392 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/M 7191 Ig-56 55 rs1338451033 0.1072 None 0.934 D 0.497 0.274 0.389439708392 gnomAD-4.0.0 6.57246E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4702E-05 0 0
T/I 7284 Ig-57 55 None 0.2745 None 0.096 N 0.491 0.326 0.464698922459 gnomAD-4.0.0 5.47474E-06 None None None None N None 0 0 None 0 0 None 5.6224E-05 0 4.49788E-06 0 0
V/M 7377 Ig-58 55 rs1490395674 0.1214 -0.646 0.06 D 0.435 0.142 0.37479162749 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
V/M 7377 Ig-58 55 rs1490395674 0.1214 -0.646 0.06 D 0.435 0.142 0.37479162749 gnomAD-4.0.0 4.77704E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57947E-06 0 0
V/L 7473 Ig-59 55 None 0.2721 None 0.792 N 0.545 0.244 0.52186301387 gnomAD-4.0.0 6.84384E-07 None None None None N None 2.99007E-05 0 None 0 0 None 0 0 0 0 0
V/M 7473 Ig-59 55 rs775242103 0.1329 -0.593 0.999 N 0.545 0.335 None gnomAD-2.1.1 7.17E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.57E-05 0
V/M 7473 Ig-59 55 rs775242103 0.1329 -0.593 0.999 N 0.545 0.335 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/M 7473 Ig-59 55 rs775242103 0.1329 -0.593 0.999 N 0.545 0.335 None gnomAD-4.0.0 5.57877E-06 None None None None N None 0 0 None 0 0 None 0 0 7.62989E-06 0 0
T/I 7569 Ig-60 55 rs1198203479 0.0937 0.674 0.044 N 0.347 0.276 0.438170831126 gnomAD-2.1.1 3.19E-05 None None None None N None 0 1.17924E-03 None 0 0 None 0 None 0 0 0
T/I 7569 Ig-60 55 rs1198203479 0.0937 0.674 0.044 N 0.347 0.276 0.438170831126 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
T/I 7569 Ig-60 55 rs1198203479 0.0937 0.674 0.044 N 0.347 0.276 0.438170831126 gnomAD-4.0.0 6.57237E-06 None None None None N None 0 6.5505E-05 None 0 0 None 0 0 0 0 0
D/N 7756 Ig-62 55 None 0.0793 None 0.001 N 0.119 0.173 0.124217242631 gnomAD-4.0.0 1.59165E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85907E-06 0 0
D/V 7756 Ig-62 55 None 0.1201 None 0.08 N 0.421 0.342 0.313210971179 gnomAD-4.0.0 1.59163E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43295E-05 0
D/Y 7756 Ig-62 55 rs534249494 0.145 -0.317 0.954 N 0.609 0.332 0.544389754888 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
D/Y 7756 Ig-62 55 rs534249494 0.145 -0.317 0.954 N 0.609 0.332 0.544389754888 gnomAD-4.0.0 7.95824E-06 None None None None N None 0 0 None 0 0 None 5.64802E-05 0 5.71814E-06 0 0
I/F 7850 Ig-63 56 None 0.1507 None 0.034 D 0.423 0.157 0.151104730317 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
I/V 7850 Ig-63 56 None 0.0636 None None N 0.105 0.248 0.219573609325 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
V/I 8039 Ig-65 55 rs759655046 0.0659 -0.59 0.009 N 0.142 0.063 0.535679682109 gnomAD-2.1.1 1.79E-05 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 2.34E-05 0
V/I 8039 Ig-65 55 rs759655046 0.0659 -0.59 0.009 N 0.142 0.063 0.535679682109 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 2.07297E-04 4.77555E-04
V/I 8039 Ig-65 55 rs759655046 0.0659 -0.59 0.009 N 0.142 0.063 0.535679682109 gnomAD-4.0.0 2.41675E-05 None None None None N None 0 1.66667E-05 None 0 0 None 0 0 2.20389E-05 1.20778E-04 1.60046E-05
V/A 8132 Ig-66 55 None 0.1735 None 0.042 N 0.315 0.173 0.513787655203 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/F 8225 Ig-67 55 None 0.515 None 0.988 N 0.597 0.394 0.745417300091 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 8318 Ig-68 55 rs200103997 0.0644 -0.731 0.008 N 0.189 0.063 None gnomAD-2.1.1 5.74659E-04 None None None None N None 8.27E-05 2.83E-05 None 0 0 None 0 None 3.19872E-04 1.14055E-03 5.61798E-04
V/I 8318 Ig-68 55 rs200103997 0.0644 -0.731 0.008 N 0.189 0.063 None gnomAD-3.1.2 5.45572E-04 None None None None N None 4.82E-05 6.55E-05 0 0 0 None 9.43E-05 0 1.14703E-03 0 4.78011E-04
V/I 8318 Ig-68 55 rs200103997 0.0644 -0.731 0.008 N 0.189 0.063 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
V/I 8318 Ig-68 55 rs200103997 0.0644 -0.731 0.008 N 0.189 0.063 None gnomAD-4.0.0 7.49198E-04 None None None None N None 9.32935E-05 1.33316E-04 None 0 2.22856E-05 None 2.18757E-04 0 9.73976E-04 0 4.80169E-04
V/A 8414 Ig-69 55 rs759822411 0.2394 -1.805 0.961 N 0.533 0.245 0.675459934904 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
V/A 8414 Ig-69 55 rs759822411 0.2394 -1.805 0.961 N 0.533 0.245 0.675459934904 gnomAD-4.0.0 1.36884E-06 None None None None N None 0 0 None 0 0 None 0 0 8.9964E-07 1.16042E-05 0
T/A 8510 Ig-70 55 None 0.1083 None 0.131 D 0.478 0.195 0.316788114976 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 3.66327E-05
T/I 8510 Ig-70 55 None 0.1476 None 0.066 N 0.259 0.119 0.325263233342 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/P 8510 Ig-70 55 rs576038518 0.7108 -0.154 0.961 N 0.571 0.408 0.516217604878 1000 genomes 2.8754E-02 None None None None N None 1.89E-02 3.89E-02 None None 4.27E-02 4.77E-02 None None None 1E-03 None
T/P 8510 Ig-70 55 rs576038518 0.7108 -0.154 0.961 N 0.571 0.408 0.516217604878 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 8604 Ig-71 56 None 0.1891 None 0.954 N 0.498 0.323 0.644857554221 gnomAD-4.0.0 1.59158E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
V/M 8604 Ig-71 56 rs1160730554 0.0834 -0.365 0.99 N 0.75 0.323 0.556850889111 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
V/M 8604 Ig-71 56 rs1160730554 0.0834 -0.365 0.99 N 0.75 0.323 0.556850889111 gnomAD-4.0.0 1.59157E-06 None None None None N None 5.66059E-05 0 None 0 0 None 0 0 0 0 0
L/R 8697 Ig-72 55 rs1364653469 0.1112 -0.44 0.141 N 0.617 0.203 0.659087871485 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
L/R 8697 Ig-72 55 rs1364653469 0.1112 -0.44 0.141 N 0.617 0.203 0.659087871485 gnomAD-4.0.0 3.18283E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86574E-05 0
I/F 8791 Ig-73 56 None 0.0973 None 0.02 N 0.445 0.187 0.331365685468 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
T/I 8980 Ig-75 55 rs777824582 0.1363 0.441 0.016 N 0.323 0.236 0.486352402194 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 6.55E-05 None 0 0 0
T/I 8980 Ig-75 55 rs777824582 0.1363 0.441 0.016 N 0.323 0.236 0.486352402194 gnomAD-4.0.0 6.15831E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99497E-07 8.11764E-05 1.65667E-05
V/D 9073 Ig-76 55 None 0.3383 None 0.642 N 0.577 0.258 0.764360434359 gnomAD-4.0.0 1.59134E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8583E-06 0 0
V/L 9073 Ig-76 55 rs756400799 0.1618 -0.527 0.002 N 0.167 0.143 0.277730125212 gnomAD-2.1.1 2.14E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.69E-05 0
V/L 9073 Ig-76 55 rs756400799 0.1618 -0.527 0.002 N 0.167 0.143 0.277730125212 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
V/L 9073 Ig-76 55 rs756400799 0.1618 -0.527 0.002 N 0.167 0.143 0.277730125212 gnomAD-4.0.0 4.2136E-05 None None None None N None 0 0 None 0 0 None 0 0 5.67901E-05 0 1.60067E-05
S/L 9166 Ig-77 55 rs773637100 0.1565 -0.337 0.996 D 0.641 0.457 0.739841096875 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
S/L 9166 Ig-77 55 rs773637100 0.1565 -0.337 0.996 D 0.641 0.457 0.739841096875 gnomAD-4.0.0 3.42096E-06 None None None None N None 2.98775E-05 0 None 0 0 None 0 0 3.59778E-06 0 0
V/I 9259 Ig-78 55 rs2076736013 0.0663 None 0.001 N 0.256 0.108 0.425148423609 gnomAD-4.0.0 6.36511E-06 None None None None N None 0 0 None 0 0 None 0 0 1.14334E-05 0 0
T/I 9355 Ig-79 55 rs763942844 0.0851 0.009 None None 0.175 0.091 0.213573922156 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
T/I 9355 Ig-79 55 rs763942844 0.0851 0.009 None None 0.175 0.091 0.213573922156 gnomAD-4.0.0 4.78929E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29622E-06 0 0
S/R 9451 Ig-80 55 rs777096848 0.21 -0.591 0.351 None 0.545 0.193 0.0920862733494 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
S/R 9451 Ig-80 55 rs777096848 0.21 -0.591 0.351 None 0.545 0.193 0.0920862733494 gnomAD-4.0.0 6.84188E-07 None None None None N None 0 0 None 0 2.51902E-05 None 0 0 0 0 0
T/K 9548 Ig-81 56 rs752064053 0.2399 -0.57 0.07 None 0.483 0.074 0.144782658237 gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 0 None 9.8E-05 None 0 0 0
T/K 9548 Ig-81 56 rs752064053 0.2399 -0.57 0.07 None 0.483 0.074 0.144782658237 gnomAD-4.0.0 1.29993E-05 None None None None N None 0 0 None 0 0 None 0 0 8.09495E-06 1.15934E-04 0
T/M 9548 Ig-81 56 rs752064053 0.0799 0.001 0.537 None 0.534 0.088 0.351180957027 gnomAD-2.1.1 2.85E-05 None None None None N None 1.65317E-04 0 None 0 0 None 3.27E-05 None 0 1.56E-05 1.40135E-04
T/M 9548 Ig-81 56 rs752064053 0.0799 0.001 0.537 None 0.534 0.088 0.351180957027 gnomAD-3.1.2 2.63E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 1.47E-05 0 0
T/M 9548 Ig-81 56 rs752064053 0.0799 0.001 0.537 None 0.534 0.088 0.351180957027 gnomAD-4.0.0 9.29502E-06 None None None None N None 1.20138E-04 1.66689E-05 None 0 0 None 0 0 1.69516E-06 2.19578E-05 1.60097E-05
E/D 9753 Ig-83 56 None 0.5027 None 0.434 None 0.254 0.04 0.315903272564 gnomAD-4.0.0 1.59096E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8577E-06 0 0
R/Q 9955 Ig-84 56 rs182332374 0.182 -0.502 0.175 None 0.301 0.1 None gnomAD-2.1.1 1.22E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.69E-05 0
R/Q 9955 Ig-84 56 rs182332374 0.182 -0.502 0.175 None 0.301 0.1 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 1.92382E-04 None 0 0 1.47E-05 0 0
R/Q 9955 Ig-84 56 rs182332374 0.182 -0.502 0.175 None 0.301 0.1 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
R/Q 9955 Ig-84 56 rs182332374 0.182 -0.502 0.175 None 0.301 0.1 None gnomAD-4.0.0 1.11615E-05 None None None None N None 0 0 None 0 2.22836E-05 None 0 0 1.35692E-05 0 1.60174E-05
V/F 10042 Ig-85 54 None 0.2921 None 0.983 None 0.73 0.319 0.674832526739 gnomAD-4.0.0 6.84139E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99397E-07 0 0
V/L 10042 Ig-85 54 None 0.3381 None 0.63 None 0.403 0.211 0.480801007081 gnomAD-4.0.0 6.84139E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
C/W 10131 Ig-86 54 rs913255032 0.699 None 0.006 None 0.415 0.259 0.465975295344 gnomAD-4.0.0 1.59087E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85745E-06 0 0
D/A 13740 Ig-87 57 rs1294256042 0.8466 None 1.0 N 0.757 0.56 0.510346895759 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/A 13740 Ig-87 57 rs1294256042 0.8466 None 1.0 N 0.757 0.56 0.510346895759 gnomAD-4.0.0 6.5754E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47093E-05 0 0
D/E 13740 Ig-87 57 rs1559992349 0.7137 None 1.0 N 0.464 0.194 0.496495002422 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
D/E 13740 Ig-87 57 rs1559992349 0.7137 None 1.0 N 0.464 0.194 0.496495002422 gnomAD-4.0.0 1.59196E-06 None None None None N None 0 0 None 0 0 None 0 2.41429E-04 0 0 0
D/N 13740 Ig-87 57 None 0.5228 None 1.0 N 0.636 0.397 0.410071178582 gnomAD-4.0.0 1.59196E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85961E-06 0 0
H/Q 13929 Ig-89 54 None 0.2107 None 0.007 N 0.243 0.043 0.0551355673512 gnomAD-4.0.0 1.63521E-06 None None None None N None 0 0 None 0 0 None 0 0 2.93708E-06 0 0
K/N 14018 Ig-90 54 rs766572300 0.7776 0.056 0.999 N 0.741 0.173 0.146414634003 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66778E-04
K/N 14018 Ig-90 54 rs766572300 0.7776 0.056 0.999 N 0.741 0.173 0.146414634003 gnomAD-4.0.0 2.05553E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80002E-06 0 1.65881E-05
K/R 14106 Ig-91 53 None 0.1687 None 0.998 N 0.511 0.232 0.403896168776 gnomAD-4.0.0 1.59243E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43316E-05 0
T/A 14195 Ig-92 54 None 0.1017 None 0.005 N 0.373 0.143 0.202086224978 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/C 14283 Ig-93 53 rs199684560 0.1657 -0.44 0.984 N 0.593 0.428 None gnomAD-2.1.1 6.79E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 1.40854E-04 0
R/C 14283 Ig-93 53 rs199684560 0.1657 -0.44 0.984 N 0.593 0.428 None gnomAD-3.1.2 4.6E-05 None None None None N None 0 0 0 0 0 None 0 0 8.83E-05 2.07469E-04 0
R/C 14283 Ig-93 53 rs199684560 0.1657 -0.44 0.984 N 0.593 0.428 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
R/C 14283 Ig-93 53 rs199684560 0.1657 -0.44 0.984 N 0.593 0.428 None gnomAD-4.0.0 5.20691E-05 None None None None N None 1.33401E-05 0 None 0 0 None 1.56455E-05 0 6.69731E-05 2.19616E-05 1.60133E-05
R/H 14283 Ig-93 53 rs767899169 0.0974 -1.39 0.005 N 0.251 0.152 0.211220785272 gnomAD-2.1.1 3.62E-05 None None None None N None 0 1.74075E-04 None 0 0 None 9.81E-05 None 0 0 0
R/P 14283 Ig-93 53 None 0.8566 None 0.705 D 0.597 0.499 0.509642975872 gnomAD-4.0.0 6.84398E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99588E-07 0 0
R/S 14283 Ig-93 53 None 0.4687 None 0.251 N 0.551 0.163 0.366848117066 gnomAD-4.0.0 6.84414E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99601E-07 0 0
K/Q 14372 Ig-94 54 rs1240174591 0.2732 -1.052 0.999 N 0.669 0.287 0.201204373187 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
K/Q 14372 Ig-94 54 rs1240174591 0.2732 -1.052 0.999 N 0.669 0.287 0.201204373187 gnomAD-4.0.0 2.73814E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59912E-06 0 0
K/E 14461 Ig-95 54 None 0.2166 None 0.124 N 0.458 0.092 0.210429274316 gnomAD-4.0.0 1.59181E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85953E-06 0 0
K/R 14461 Ig-95 54 rs887333870 0.0568 None None N 0.11 0.167 0.0716867268079 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
K/R 14461 Ig-95 54 rs887333870 0.0568 None None N 0.11 0.167 0.0716867268079 gnomAD-4.0.0 2.47924E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39093E-06 0 0
T/P 14550 Ig-96 54 rs2059896873 0.4625 None 0.568 N 0.585 0.301 0.373537453441 gnomAD-4.0.0 6.86621E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01448E-07 0 0
I/L 14728 Ig-98 54 None 0.1156 None None N 0.061 0.06 0.117506650769 gnomAD-4.0.0 1.59929E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86528E-06 0 0
I/M 14728 Ig-98 54 rs572315033 0.0994 -0.942 None N 0.339 0.037 None gnomAD-2.1.1 4.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
I/M 14728 Ig-98 54 rs572315033 0.0994 -0.942 None N 0.339 0.037 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/M 14728 Ig-98 54 rs572315033 0.0994 -0.942 None N 0.339 0.037 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
I/M 14728 Ig-98 54 rs572315033 0.0994 -0.942 None N 0.339 0.037 None gnomAD-4.0.0 1.86256E-05 None None None None N None 2.67101E-05 0 None 0 0 None 0 0 2.37505E-05 0 0
I/T 14728 Ig-98 54 None 0.1771 None None N 0.151 0.069 0.139678290688 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/L 14906 Ig-100 54 None 0.2321 None 0.906 N 0.477 0.218 0.410734915765 gnomAD-4.0.0 1.59336E-06 None None None None N None 0 0 None 0 2.78164E-05 None 0 0 0 0 0
K/E 15084 Ig-102 54 None 0.3115 None 0.989 D 0.477 0.421 0.464270400615 gnomAD-4.0.0 3.18747E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72554E-06 0 0
K/M 15173 Ig-103 54 None 0.3851 None 0.999 D 0.686 0.395 0.468753983522 gnomAD-4.0.0 1.59378E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43373E-05 0
V/D 15261 Ig-104 54 rs978618827 0.6123 -2.158 0.901 D 0.777 0.374 0.770231283977 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
V/D 15261 Ig-104 54 rs978618827 0.6123 -2.158 0.901 D 0.777 0.374 0.770231283977 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 4.78469E-04
V/D 15261 Ig-104 54 rs978618827 0.6123 -2.158 0.901 D 0.777 0.374 0.770231283977 gnomAD-4.0.0 7.4407E-06 None None None None N None 0 0 None 0 0 None 0 3.30579E-04 5.9363E-06 0 4.80677E-05
K/N 15355 Ig-105 54 rs397517583 0.7614 -1.757 0.999 D 0.683 0.306 0.243972157842 gnomAD-2.1.1 2.98811E-04 None None None None N None 0 0 None 0 0 None 2.42004E-03 None 0 0 0
K/N 15355 Ig-105 54 rs397517583 0.7614 -1.757 0.999 D 0.683 0.306 0.243972157842 gnomAD-3.1.2 8.56E-05 None None None None N None 0 0 0 0 0 None 0 0 0 2.6904E-03 0
K/N 15355 Ig-105 54 rs397517583 0.7614 -1.757 0.999 D 0.683 0.306 0.243972157842 1000 genomes 5.99042E-04 None None None None N None 0 0 None None 0 0 None None None 3.1E-03 None
K/N 15355 Ig-105 54 rs397517583 0.7614 -1.757 0.999 D 0.683 0.306 0.243972157842 gnomAD-4.0.0 1.35205E-04 None None None None N None 0 0 None 0 0 None 0 0 0 2.3403E-03 8.01231E-05
K/Q 15355 Ig-105 54 None 0.2421 None 0.999 D 0.669 0.418 0.365892764245 gnomAD-4.0.0 1.3695E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80004E-06 0 0
K/R 15355 Ig-105 54 rs776832569 0.0951 -1.377 0.64 N 0.275 0.21 None gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
I/V 15444 Ig-106 54 rs1333036641 0.0792 -1.227 None N 0.109 0.126 0.310458034454 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 5.64E-05 None 0 None 0 0 0
I/V 15444 Ig-106 54 rs1333036641 0.0792 -1.227 None N 0.109 0.126 0.310458034454 gnomAD-4.0.0 1.59876E-06 None None None None N None 0 0 None 0 2.78583E-05 None 0 0 0 0 0
I/L 15533 Ig-107 54 rs1406271344 0.1201 -1.07 0.001 N 0.16 0.09 0.475741759771 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/L 15533 Ig-107 54 rs1406271344 0.1201 -1.07 0.001 N 0.16 0.09 0.475741759771 gnomAD-4.0.0 1.5939E-06 None None None None N None 0 2.28885E-05 None 0 0 None 0 0 0 0 0
I/T 15533 Ig-107 54 rs777059640 0.2157 -1.741 0.007 N 0.269 0.272 0.594932130068 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
I/T 15533 Ig-107 54 rs777059640 0.2157 -1.741 0.007 N 0.269 0.272 0.594932130068 gnomAD-3.1.2 6.59E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
I/T 15533 Ig-107 54 rs777059640 0.2157 -1.741 0.007 N 0.269 0.272 0.594932130068 gnomAD-4.0.0 1.86067E-06 None None None None N None 2.6743E-05 0 None 0 0 None 0 0 8.4822E-07 0 0
I/V 15533 Ig-107 54 None 0.0734 None None N 0.159 0.123 0.404733080969 gnomAD-4.0.0 1.5939E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43386E-05 0
Y/C 16017 Ig-109 50 None 0.1687 None 0.997 N 0.583 0.418 0.636530080196 gnomAD-4.0.0 6.84615E-07 None None None None N None 0 0 None 0 2.52704E-05 None 0 0 0 0 0
Y/S 16017 Ig-109 50 None 0.2089 None 0.891 N 0.582 0.324 0.68695168648 gnomAD-4.0.0 6.84615E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99852E-06 0 0
K/I 16313 Ig-110 52 None 0.398 None 0.927 N 0.481 0.313 0.493964856914 gnomAD-4.0.0 1.59406E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86256E-06 0 0
S/P 17009 Ig-111 55 None 0.8198 None 1.0 D 0.818 0.527 0.3571064206 gnomAD-4.0.0 2.05369E-06 None None None None N None 0 0 None 0 0 None 0 0 2.6995E-06 0 0
E/G 17331 Ig-112 81 None 0.2554 None 0.801 N 0.55 0.174 0.359357374593 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/Q 17331 Ig-112 81 rs547986881 0.1183 0.535 0.961 N 0.502 0.175 0.31077124679 gnomAD-2.1.1 6.04345E-04 None None None None N None 0 5.75E-05 None 0 0 None 5.43114E-03 None 0 0 4.28082E-04
E/Q 17331 Ig-112 81 rs547986881 0.1183 0.535 0.961 N 0.502 0.175 0.31077124679 gnomAD-3.1.2 1.44786E-04 None None None None N None 0 0 0 0 0 None 0 0 0 4.55675E-03 0
E/Q 17331 Ig-112 81 rs547986881 0.1183 0.535 0.961 N 0.502 0.175 0.31077124679 1000 genomes 9.98403E-04 None None None None N None 0 0 None None 0 0 None None None 5.1E-03 None
E/Q 17331 Ig-112 81 rs547986881 0.1183 0.535 0.961 N 0.502 0.175 0.31077124679 gnomAD-4.0.0 2.90303E-04 None None None None N None 0 3.36508E-05 None 0 2.24437E-05 None 0 3.31895E-04 2.54828E-06 4.92802E-03 2.25051E-04
K/E 18027 Ig-114 60 rs374256705 0.2451 -2.069 0.961 N 0.749 0.195 None gnomAD-2.1.1 8.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
K/E 18027 Ig-114 60 rs374256705 0.2451 -2.069 0.961 N 0.749 0.195 None gnomAD-4.0.0 1.59331E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86228E-06 0 0
T/A 18746 Ig-116 59 None 0.0865 None 0.139 N 0.281 0.161 0.21279746466 gnomAD-4.0.0 3.18579E-06 None None None None I None 0 0 None 0 0 None 0 0 5.72243E-06 0 0
T/I 18746 Ig-116 59 rs762145585 0.1252 0.178 0.784 N 0.496 0.228 0.315609569513 gnomAD-2.1.1 8.06E-06 None None None None I None 0 0 None 0 5.59E-05 None 0 None 0 8.91E-06 0
T/I 18746 Ig-116 59 rs762145585 0.1252 0.178 0.784 N 0.496 0.228 0.315609569513 gnomAD-4.0.0 1.59294E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86134E-06 0 0
T/P 18746 Ig-116 59 None 0.6701 None 0.784 N 0.491 0.357 0.331365685468 gnomAD-4.0.0 1.59289E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86121E-06 0 0
S/R 19145 Ig-117 51 rs775238770 0.9853 -0.393 0.997 N 0.719 0.45 0.316494231283 gnomAD-2.1.1 8.06E-06 None None None None N None 0 5.81E-05 None 0 0 None 0 None 0 0 0
S/R 19145 Ig-117 51 rs775238770 0.9853 -0.393 0.997 N 0.719 0.45 0.316494231283 gnomAD-4.0.0 2.05323E-06 None None None None N None 0 6.71411E-05 None 0 0 None 0 0 0 0 0
S/T 19145 Ig-117 51 rs2154189870 0.3442 None 0.989 N 0.472 0.267 0.165133752707 gnomAD-4.0.0 3.18474E-06 None None None None N None 5.66123E-05 0 None 0 0 None 0 0 2.85992E-06 0 0
T/A 19441 Ig-118 51 None 0.0884 None 0.98 N 0.475 0.251 0.444505407614 gnomAD-4.0.0 1.59185E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43299E-05 0
G/D 19839 Ig-119 50 rs1256321814 0.8289 0.192 0.467 N 0.341 0.234 0.144782658237 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
G/D 19839 Ig-119 50 rs1256321814 0.8289 0.192 0.467 N 0.341 0.234 0.144782658237 gnomAD-4.0.0 2.05296E-06 None None None None N None 0 2.23664E-05 None 0 0 None 0 0 1.79917E-06 0 0
S/P 20133 Ig-120 54 rs769272954 0.958 -0.508 0.999 N 0.768 0.508 None gnomAD-2.1.1 8.04E-06 None None None None N None 1.29232E-04 0 None 0 0 None 0 None 0 0 0
S/P 20133 Ig-120 54 rs769272954 0.958 -0.508 0.999 N 0.768 0.508 None gnomAD-4.0.0 1.59223E-06 None None None None N None 5.66508E-05 0 None 0 0 None 0 0 0 0 0
R/C 20531 Ig-121 53 rs748005350 0.1602 -0.702 0.975 N 0.463 0.37 0.557405679382 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 8.91E-06 0
R/C 20531 Ig-121 53 rs748005350 0.1602 -0.702 0.975 N 0.463 0.37 0.557405679382 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
R/C 20531 Ig-121 53 rs748005350 0.1602 -0.702 0.975 N 0.463 0.37 0.557405679382 gnomAD-4.0.0 3.09969E-06 None None None None N None 1.33611E-05 0 None 0 0 None 0 0 2.5435E-06 0 1.60159E-05
R/H 20531 Ig-121 53 rs370887455 0.0974 -1.428 0.006 N 0.158 0.219 None gnomAD-2.1.1 1.79E-05 None None None None N None 4.14E-05 0 None 0 0 None 0 None 0 2.35E-05 1.40766E-04
R/H 20531 Ig-121 53 rs370887455 0.0974 -1.428 0.006 N 0.158 0.219 None gnomAD-3.1.2 1.32E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
R/H 20531 Ig-121 53 rs370887455 0.0974 -1.428 0.006 N 0.158 0.219 None gnomAD-4.0.0 2.54167E-05 None None None None N None 4.00727E-05 3.33622E-05 None 0 0 None 0 0 2.88262E-05 0 3.20338E-05
R/L 20531 Ig-121 53 rs370887455 0.1829 0.191 0.001 N 0.187 0.3 0.406945738958 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
R/L 20531 Ig-121 53 rs370887455 0.1829 0.191 0.001 N 0.187 0.3 0.406945738958 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
R/L 20531 Ig-121 53 rs370887455 0.1829 0.191 0.001 N 0.187 0.3 0.406945738958 gnomAD-4.0.0 2.47968E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.39396E-05 0
M/K 21228 Ig-123 52 None 0.5816 None 0.994 N 0.563 0.526 0.808737173022 gnomAD-4.0.0 6.84639E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65793E-05
M/T 21228 Ig-123 52 rs1397983700 0.5441 None 0.994 N 0.563 0.512 0.812414231654 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
M/T 21228 Ig-123 52 rs1397983700 0.5441 None 0.994 N 0.563 0.512 0.812414231654 gnomAD-4.0.0 6.84639E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99724E-07 0 0
M/V 21228 Ig-123 52 None 0.2001 None 0.985 N 0.45 0.446 0.703477315268 gnomAD-4.0.0 1.36927E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79946E-06 0 0
S/F 21521 Ig-124 53 rs766887868 0.1935 -0.67 0.934 N 0.686 0.331 0.665958451526 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
S/F 21521 Ig-124 53 rs766887868 0.1935 -0.67 0.934 N 0.686 0.331 0.665958451526 gnomAD-4.0.0 1.59226E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86053E-06 0 0
D/E 22316 Ig-126 52 None 0.7489 None 0.979 D 0.483 0.258 0.325533332567 gnomAD-4.0.0 6.84438E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99679E-07 0 0
D/N 22316 Ig-126 52 rs948813723 0.5725 None 0.988 N 0.72 0.306 0.30212335484 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
D/N 22316 Ig-126 52 rs948813723 0.5725 None 0.988 N 0.72 0.306 0.30212335484 gnomAD-4.0.0 8.67904E-06 None None None None N None 0 0 None 0 0 None 0 0 1.18696E-05 0 0
S/F 23002 Ig-128 53 rs1469065762 0.2341 -1.153 0.97 N 0.781 0.488 0.765205214495 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
S/F 23002 Ig-128 53 rs1469065762 0.2341 -1.153 0.97 N 0.781 0.488 0.765205214495 gnomAD-4.0.0 3.42178E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.63822E-05 1.65728E-05
S/Y 23002 Ig-128 53 None 0.2064 None 0.99 N 0.782 0.489 0.766266904961 gnomAD-4.0.0 2.05307E-06 None None None None N None 0 0 None 0 5.04898E-05 None 0 0 8.99606E-07 0 0
F/C 23397 Ig-129 53 rs1409813527 0.677 None 1.0 N 0.65 0.34 0.748869319524 gnomAD-4.0.0 7.53357E-06 None None None None N None 0 0 None 0 0 None 0 0 9.90477E-06 0 0
F/L 23397 Ig-129 53 rs1445569607 0.9839 -1.258 0.91 N 0.389 0.357 0.416328079214 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
F/L 23397 Ig-129 53 rs1445569607 0.9839 -1.258 0.91 N 0.389 0.357 0.416328079214 gnomAD-4.0.0 1.59584E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87086E-06 0 0
S/A 23688 Ig-130 52 rs935595558 0.0709 None 0.02 D 0.299 0.13 0.257786959452 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/A 23688 Ig-130 52 rs935595558 0.0709 None 0.02 D 0.299 0.13 0.257786959452 gnomAD-4.0.0 2.56368E-06 None None None None N None 1.69199E-05 0 None 0 0 None 0 0 2.39402E-06 0 0
S/P 24084 Ig-131 56 None 0.842 None 0.996 D 0.563 0.378 0.479133204078 gnomAD-4.0.0 2.74154E-06 None None None None N None 0 0 None 0 0 None 0 0 3.60385E-06 0 0
A/V 25166 Ig-134 56 rs753641145 0.0946 -0.305 None N 0.184 0.096 0.32471235697 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
A/V 25166 Ig-134 56 rs753641145 0.0946 -0.305 None N 0.184 0.096 0.32471235697 gnomAD-4.0.0 8.21211E-06 None None None None N None 0 0 None 0 0 None 0 0 1.0795E-05 0 0
F/Y 25563 Ig-135 50 rs1273963065 0.1028 -0.242 0.219 N 0.178 0.188 0.404453528171 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
F/Y 25563 Ig-135 50 rs1273963065 0.1028 -0.242 0.219 N 0.178 0.188 0.404453528171 gnomAD-4.0.0 4.77775E-06 None None None None N None 0 0 None 0 0 None 0 0 8.58079E-06 0 0
L/I 25852 Ig-136 55 None 0.0646 None 0.684 N 0.422 0.201 0.519514513453 gnomAD-4.0.0 1.59195E-06 None None None None N None 0 0 None 0 2.77408E-05 None 0 0 0 0 0
L/V 25852 Ig-136 55 None 0.0584 None 0.684 N 0.417 0.252 0.542363599239 gnomAD-4.0.0 1.59195E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85976E-06 0 0
K/Q 26248 Ig-137 56 rs1281337813 0.1228 -0.587 0.901 N 0.579 0.309 0.281780670237 gnomAD-2.1.1 4.23E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.23E-06 0
K/Q 26248 Ig-137 56 rs1281337813 0.1228 -0.587 0.901 N 0.579 0.309 0.281780670237 gnomAD-4.0.0 2.76372E-06 None None None None N None 0 0 None 0 0 None 0 0 2.71282E-06 0 1.67527E-05
K/N 27331 Ig-140 54 None 0.2476 None 0.002 N 0.284 0.127 0.0986583533028 gnomAD-4.0.0 1.5913E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
V/I 28017 Ig-142 55 rs777711368 0.0714 -0.36 0.166 N 0.343 0.08 0.510872562601 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.99E-06 0
V/I 28017 Ig-142 55 rs777711368 0.0714 -0.36 0.166 N 0.343 0.08 0.510872562601 gnomAD-4.0.0 3.18518E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85997E-06 1.43406E-05 0
R/C 28807 Ig-144 53 rs765632053 0.0857 -1.311 0.001 N 0.325 0.167 0.363158594168 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07555E-04 0
R/H 28807 Ig-144 53 rs375800916 0.072 -1.794 0.001 N 0.271 0.054 None gnomAD-2.1.1 5.18E-05 None None None None I None 0 0 None 0 5.15E-05 None 0 None 0 1.04736E-04 0
R/H 28807 Ig-144 53 rs375800916 0.072 -1.794 0.001 N 0.271 0.054 None gnomAD-3.1.2 4.6E-05 None None None None I None 0 0 0 0 0 None 0 0 1.02908E-04 0 0
R/H 28807 Ig-144 53 rs375800916 0.072 -1.794 0.001 N 0.271 0.054 None gnomAD-4.0.0 2.12098E-04 None None None None I None 1.33854E-05 1.68509E-05 None 3.48165E-05 0 None 0 0 2.82754E-04 0 8.07024E-05
R/L 28807 Ig-144 53 None 0.1895 None 0.03 N 0.431 0.109 0.265929055128 gnomAD-4.0.0 6.89223E-07 None None None None I None 0 0 None 0 0 None 0 0 9.04041E-07 0 0
N/H 29099 Ig-145 55 rs1702188793 0.0961 None 0.975 N 0.452 0.229 0.253726318573 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
N/K 29099 Ig-145 55 rs528257030 0.2267 -0.044 0.425 N 0.322 0.111 0.144782658237 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
N/K 29099 Ig-145 55 rs528257030 0.2267 -0.044 0.425 N 0.322 0.111 0.144782658237 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
N/K 29099 Ig-145 55 rs528257030 0.2267 -0.044 0.425 N 0.322 0.111 0.144782658237 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
N/K 29099 Ig-145 55 rs528257030 0.2267 -0.044 0.425 N 0.322 0.111 0.144782658237 gnomAD-4.0.0 6.56607E-06 None None None None N None 2.40547E-05 0 None 0 0 None 0 0 0 0 0
S/A 29894 Ig-147 53 None 0.1123 None 0.333 N 0.26 0.116 0.258283824007 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/F 30581 Ig-149 50 None 0.1863 None 0.002 N 0.381 0.211 0.568643509186 gnomAD-4.0.0 1.59126E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8583E-06 0 0
F/L 30978 Ig-150 52 None 0.9381 None 0.013 N 0.155 0.174 0.310458034454 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/K 31270 Ig-151 53 rs1280335651 0.1301 None 0.997 N 0.486 0.261 0.337135696972 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
R/T 31270 Ig-151 53 rs1280335651 0.2924 None 1.0 N 0.739 0.405 0.610711448424 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/T 31270 Ig-151 53 rs1280335651 0.2924 None 1.0 N 0.739 0.405 0.610711448424 gnomAD-4.0.0 4.05978E-06 None None None None N None 1.74697E-05 0 None 0 0 None 0 0 3.61475E-06 0 0
R/Q 31670 Ig-152 50 rs750410616 0.1237 -0.052 0.997 N 0.606 0.334 0.28297238246 gnomAD-2.1.1 2.41E-05 None None None None N None 0 1.73792E-04 None 0 0 None 0 None 0 0 0
R/Q 31670 Ig-152 50 rs750410616 0.1237 -0.052 0.997 N 0.606 0.334 0.28297238246 gnomAD-4.0.0 9.57883E-06 None None None None N None 0 1.78883E-04 None 0 0 None 0 0 2.69842E-06 3.47802E-05 0
Y/C 32067 Ig-153 51 None 0.1786 None 1.0 N 0.683 0.433 0.509168631294 gnomAD-4.0.0 1.59143E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85876E-06 0 0
Y/H 32067 Ig-153 51 None 0.3015 None 0.998 N 0.539 0.295 0.345859378078 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
V/E 32361 Ig-154 55 rs773186045 0.2123 -2.449 0.351 N 0.514 0.279 0.696243023549 gnomAD-2.1.1 7.15E-06 None None None None N None 0 0 None 0 0 None 0 None 0 7.83E-06 1.40449E-04
V/E 32361 Ig-154 55 rs773186045 0.2123 -2.449 0.351 N 0.514 0.279 0.696243023549 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/E 32361 Ig-154 55 rs773186045 0.2123 -2.449 0.351 N 0.514 0.279 0.696243023549 gnomAD-4.0.0 4.95772E-06 None None None None N None 0 0 None 0 0 None 0 0 5.93337E-06 0 1.60113E-05
V/I 32361 Ig-154 55 rs766538774 0.0821 -0.646 0.101 N 0.389 0.051 0.378674557249 gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 1.57E-05 0
V/I 32361 Ig-154 55 rs766538774 0.0821 -0.646 0.101 N 0.389 0.051 0.378674557249 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 4.14079E-04 0
V/I 32361 Ig-154 55 rs766538774 0.0821 -0.646 0.101 N 0.389 0.051 0.378674557249 gnomAD-4.0.0 6.19706E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39043E-06 4.39155E-05 3.20215E-05
V/L 32361 Ig-154 55 rs766538774 0.1768 -0.649 0.017 N 0.333 0.108 0.319114376414 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 4.64E-05 0 0
V/L 32361 Ig-154 55 rs766538774 0.1768 -0.649 0.017 N 0.333 0.108 0.319114376414 gnomAD-4.0.0 6.84197E-07 None None None None N None 0 0 None 0 0 None 1.87294E-05 0 0 0 0
H/N 32757 Ig-155 50 rs1438849988 0.1074 -0.333 0.912 N 0.285 0.222 0.42886291518 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
H/N 32757 Ig-155 50 rs1438849988 0.1074 -0.333 0.912 N 0.285 0.222 0.42886291518 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
H/N 32757 Ig-155 50 rs1438849988 0.1074 -0.333 0.912 N 0.285 0.222 0.42886291518 gnomAD-4.0.0 3.0449E-06 None None None None N None 0 0 None 0 0 None 0 0 3.61476E-06 0 0
T/A 33155 Ig-156 55 rs1692258849 0.1028 None 0.525 N 0.497 0.258 0.290590437066 gnomAD-4.0.0 3.18264E-06 None None None None N None 5.65739E-05 0 None 0 0 None 0 0 0 1.43275E-05 0
T/I 33155 Ig-156 55 rs1179270927 0.1371 0.564 0.996 N 0.682 0.273 0.467247493403 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
T/I 33155 Ig-156 55 rs1179270927 0.1371 0.564 0.996 N 0.682 0.273 0.467247493403 gnomAD-4.0.0 2.05265E-06 None None None None N None 0 0 None 0 2.5194E-05 None 0 0 1.79895E-06 0 0
Y/C 33251 Ig-157 49 rs377456237 0.5982 -1.51 1.0 N 0.679 0.524 None gnomAD-2.1.1 7.16E-06 None None None None N None 8.29E-05 0 None 0 0 None 0 None 0 0 0
Y/C 33251 Ig-157 49 rs377456237 0.5982 -1.51 1.0 N 0.679 0.524 None gnomAD-3.1.2 2.63E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 4.78011E-04
Y/C 33251 Ig-157 49 rs377456237 0.5982 -1.51 1.0 N 0.679 0.524 None gnomAD-4.0.0 4.33918E-06 None None None None N None 5.34088E-05 0 None 0 0 None 0 0 1.6955E-06 0 1.60164E-05
Y/C 33552 Ig-158 57 rs768683486 0.884 -0.731 1.0 D 0.735 0.517 0.682531388322 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
Y/C 33552 Ig-158 57 rs768683486 0.884 -0.731 1.0 D 0.735 0.517 0.682531388322 gnomAD-4.0.0 2.05619E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70299E-06 0 0
F/C 33650 Ig-159 55 None 0.9611 None 1.0 D 0.759 0.614 0.663301836877 gnomAD-4.0.0 4.78946E-06 None None None None N None 0 0 None 0 0 None 0 0 6.2963E-06 0 0
V/G 34191 Ig-160 55 None 0.3833 None 0.055 N 0.617 0.292 0.623427226985 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
V/M 34191 Ig-160 55 None 0.126 None 0.005 N 0.244 0.073 0.29527378943 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/I 34315 Ig-161 58 rs1305429779 0.2329 None 0.955 N 0.521 0.279 0.503621591648 gnomAD-4.0.0 1.59103E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85767E-06 0 0
L/V 34315 Ig-161 58 rs1305429779 0.3299 None 0.955 N 0.566 0.294 0.507687591559 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
L/V 34315 Ig-161 58 rs1305429779 0.3299 None 0.955 N 0.566 0.294 0.507687591559 gnomAD-4.0.0 1.59103E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02371E-05
V/A 34996 Ig-163 55 rs2154133672 0.7728 None 0.999 N 0.53 0.364 0.628255493996 gnomAD-4.0.0 3.18178E-06 None None None None I None 0 0 None 0 0 None 0 0 5.7151E-06 0 0
V/F 34996 Ig-163 55 rs772718460 0.532 -1.071 1.0 N 0.767 0.467 0.735330036385 gnomAD-2.1.1 6.37E-05 None None None None I None 1.14863E-04 0 None 0 0 None 0 None 0 6.48E-05 0
V/F 34996 Ig-163 55 rs772718460 0.532 -1.071 1.0 N 0.767 0.467 0.735330036385 gnomAD-3.1.2 1.97E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
V/F 34996 Ig-163 55 rs772718460 0.532 -1.071 1.0 N 0.767 0.467 0.735330036385 gnomAD-4.0.0 2.47847E-06 None None None None I None 1.33461E-05 0 None 0 0 None 0 0 2.54259E-06 0 0
V/I 34996 Ig-163 55 rs772718460 0.1256 -0.278 0.997 D 0.489 0.214 0.671718306961 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.86E-06 0
V/I 34996 Ig-163 55 rs772718460 0.1256 -0.278 0.997 D 0.489 0.214 0.671718306961 gnomAD-4.0.0 4.78898E-06 None None None None I None 2.98704E-05 0 None 0 0 None 0 0 4.49699E-06 0 1.65634E-05
K/E 35183 Ig-164 55 None 0.7231 None 0.166 N 0.536 0.193 0.266843984389 gnomAD-4.0.0 1.32035E-05 None None None None N None 0 0 None 0 0 None 0 0 1.44375E-05 0 0
G/A 35474 Ig-166 55 None 0.0651 None None N 0.162 0.083 0.0611884634855 gnomAD-4.0.0 1.59814E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.03251E-05
G/V 35474 Ig-166 55 rs747075406 0.061 0.345 None N 0.477 0.107 0.128392430309 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 3.36E-05 None 0 0 0
G/V 35474 Ig-166 55 rs747075406 0.061 0.345 None N 0.477 0.107 0.128392430309 gnomAD-4.0.0 3.19628E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.9074E-05 0
D/N 35659 Ig-167 53 rs878992336 0.1682 0.384 0.102 N 0.227 0.116 None gnomAD-2.1.1 1.43E-05 None None None None N None 4.14E-05 0 None 0 0 None 3.28E-05 None 0 1.56E-05 0
D/N 35659 Ig-167 53 rs878992336 0.1682 0.384 0.102 N 0.227 0.116 None gnomAD-3.1.2 3.94E-05 None None None None N None 7.24E-05 6.55E-05 0 0 0 None 0 0 2.94E-05 0 0
D/N 35659 Ig-167 53 rs878992336 0.1682 0.384 0.102 N 0.227 0.116 None gnomAD-4.0.0 7.44257E-06 None None None None N None 4.00545E-05 1.66895E-05 None 0 0 None 0 1.64636E-04 5.93805E-06 0 0
D/Y 35659 Ig-167 53 None 0.4509 None 0.999 N 0.764 0.386 0.671546516869 gnomAD-4.0.0 6.84829E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00234E-07 0 0
V/A 35756 Ig-168 55 rs16866378 0.1534 -1.493 0.001 N 0.119 0.135 None gnomAD-2.1.1 4.51767E-02 None None None None N None 1.2866E-01 3.40536E-02 None 4.16586E-02 1.75615E-01 None 4.98791E-02 None 3.15697E-03 2.03248E-02 3.9422E-02
V/A 35756 Ig-168 55 rs16866378 0.1534 -1.493 0.001 N 0.119 0.135 None gnomAD-3.1.2 5.7505E-02 None None None None N None 1.26986E-01 4.54783E-02 8.77193E-03 4.20749E-02 1.66603E-01 None 2.35272E-03 6.01266E-02 2.02117E-02 4.67909E-02 6.26195E-02
V/A 35756 Ig-168 55 rs16866378 0.1534 -1.493 0.001 N 0.119 0.135 None 1000 genomes 9.20527E-02 None None None None N None 1.354E-01 4.03E-02 None None 1.736E-01 3.18E-02 None None None 4.81E-02 None
V/A 35756 Ig-168 55 rs16866378 0.1534 -1.493 0.001 N 0.119 0.135 None gnomAD-4.0.0 3.26231E-02 None None None None N None 1.27823E-01 3.87038E-02 None 4.24691E-02 1.77392E-01 None 3.17069E-03 9.78225E-02 2.01213E-02 4.90448E-02 4.01716E-02
V/L 35756 Ig-168 55 None 0.1609 None 0.015 N 0.255 0.114 0.110078149338 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/M 35953 Ig-169 57 None 0.2794 None 0.997 N 0.641 0.213 0.567280287869 gnomAD-4.0.0 1.59092E-06 None None None -0.731(OBSL1) -0.865(OBSCN) N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
L/R 35953 Ig-169 57 rs794729572 0.6246 None 0.999 N 0.743 0.499 None gnomAD-3.1.2 6.57E-06 None None None -1.961(OBSL1) -1.67(OBSCN) N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/R 35953 Ig-169 57 rs794729572 0.6246 None 0.999 N 0.743 0.499 None gnomAD-4.0.0 3.84243E-06 None None None -1.961(OBSL1) -1.67(OBSCN) N None 0 0 None 0 0 None 0 0 7.17724E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.