Structural position:

  • Domain Type: Ig
  • Aligned Position: 137
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand E

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
K/I 64 Ig-1 59 None 0.2331 None 0.001 N 0.515 0.232 0.20549828249 gnomAD-4.0.0 1.59049E-06 None None None -0.354(TCAP) N None 0 0 None 0 0 None 0 0 0 0 3.02151E-05
S/C 160 Ig-2 57 None 0.4177 None 1.0 D 0.797 0.643 0.631214040921 gnomAD-4.0.0 1.20032E-06 None None None -0.255(TCAP) N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/G 160 Ig-2 57 rs1482623810 0.3953 -1.541 1.0 D 0.617 0.546 0.408036853922 gnomAD-2.1.1 3.98E-06 None None None -0.031(TCAP) N None 0 0 None 0 0 None 0 None 0 8.79E-06 0
S/N 160 Ig-2 57 None 0.4907 None 0.997 D 0.619 0.358 0.363158594168 gnomAD-4.0.0 1.20032E-06 None None None -0.552(TCAP) N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/C 999 Ig-3 57 rs142000511 0.2786 -0.975 1.0 N 0.764 0.629 None gnomAD-2.1.1 1.2E-05 None None None None N None 1.23062E-04 0 None 0 0 None 0 None 0 8.83E-06 0
R/C 999 Ig-3 57 rs142000511 0.2786 -0.975 1.0 N 0.764 0.629 None gnomAD-4.0.0 6.84079E-06 None None None None N None 2.98704E-05 0 None 0 0 None 0 0 6.29513E-06 2.31863E-05 0
R/H 999 Ig-3 57 None 0.1293 -1.723 0.999 N 0.577 0.446 None gnomAD-2.1.1 2.83E-05 None None None None N None 0 0 None 0 2.51155E-04 None 0 None 0 2.33E-05 0
R/H 999 Ig-3 57 None 0.1293 -1.723 0.999 N 0.577 0.446 None gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 3.85654E-04 None 0 0 4.41E-05 0 0
R/H 999 Ig-3 57 None 0.1293 -1.723 0.999 N 0.577 0.446 None gnomAD-4.0.0 1.98256E-05 None None None None N None 1.33276E-05 0 None 0 1.78341E-04 None 0 0 1.77966E-05 2.19606E-05 0
R/L 999 Ig-3 57 rs371757623 0.508 None 0.996 N 0.653 0.443 0.667830379453 gnomAD-4.0.0 1.36816E-06 None None None None N None 2.98704E-05 0 None 0 0 None 0 0 8.99305E-07 0 0
R/S 999 Ig-3 57 None 0.6591 None 0.831 N 0.439 0.498 0.348764635752 gnomAD-4.0.0 6.8408E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
K/M 1140 Ig-4 59 rs769789570 0.2487 -0.17 0.915 N 0.561 0.235 None gnomAD-2.1.1 1.99E-05 None None None None N None 0 0 None 0 5.45E-05 None 0 None 0 3.52E-05 0
K/M 1140 Ig-4 59 rs769789570 0.2487 -0.17 0.915 N 0.561 0.235 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
K/M 1140 Ig-4 59 rs769789570 0.2487 -0.17 0.915 N 0.561 0.235 None gnomAD-4.0.0 9.91349E-06 None None None None N None 0 0 None 0 0 None 0 0 1.27121E-05 0 1.60056E-05
K/N 1140 Ig-4 59 None 0.483 None 0.117 N 0.495 0.105 0.0884992946249 gnomAD-4.0.0 1.5908E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85687E-06 0 0
K/Q 1140 Ig-4 59 rs1561345560 0.1155 None 0.062 N 0.533 0.177 0.183819452728 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.81E-06 0
K/Q 1140 Ig-4 59 rs1561345560 0.1155 None 0.062 N 0.533 0.177 0.183819452728 gnomAD-4.0.0 1.5908E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85687E-06 0 0
S/G 1348 Ig-5 58 rs397517591 0.3666 -1.127 0.822 N 0.547 0.396 0.351180957027 gnomAD-2.1.1 2.39E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 2.65E-05 3.27439E-04
S/G 1348 Ig-5 58 rs397517591 0.3666 -1.127 0.822 N 0.547 0.396 0.351180957027 gnomAD-3.1.2 1.31E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 2.06954E-04 0
S/G 1348 Ig-5 58 rs397517591 0.3666 -1.127 0.822 N 0.547 0.396 0.351180957027 gnomAD-4.0.0 1.5368E-05 None None None None N None 0 5.08423E-05 None 0 0 None 0 0 1.67437E-05 1.34005E-05 2.84188E-05
S/T 1348 Ig-5 58 None 0.1356 None 0.014 N 0.405 0.096 0.184867976434 gnomAD-4.0.0 1.59085E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
S/R 1761 Ig-8 59 rs1187984311 0.9616 -0.638 1.0 N 0.719 0.737 0.496099317193 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
S/R 1761 Ig-8 59 rs1187984311 0.9616 -0.638 1.0 N 0.719 0.737 0.496099317193 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/R 1761 Ig-8 59 rs1187984311 0.9616 -0.638 1.0 N 0.719 0.737 0.496099317193 gnomAD-4.0.0 1.36849E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7986E-06 0 0
F/C 2230 Ig-11 57 None 0.8051 None 0.997 N 0.732 0.536 0.781051952282 gnomAD-4.0.0 6.84128E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99336E-07 0 0
N/I 2322 Ig-12 56 rs1283394684 0.0777 0.228 0.006 N 0.522 0.343 0.438806408302 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
N/I 2322 Ig-12 56 rs1283394684 0.0777 0.228 0.006 N 0.522 0.343 0.438806408302 gnomAD-4.0.0 1.59057E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85675E-06 0 0
M/V 2411 Ig-13 56 rs1333177270 0.2454 -1.413 0.811 N 0.419 0.334 0.558578966169 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
M/V 2411 Ig-13 56 rs1333177270 0.2454 -1.413 0.811 N 0.419 0.334 0.558578966169 gnomAD-4.0.0 1.36815E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79862E-06 0 0
R/G 2501 Ig-14 57 rs781459488 0.8853 -1.736 1.0 D 0.732 0.495 0.577469734466 gnomAD-2.1.1 1.99E-05 None None None None N None 0 0 None 0 0 None 1.63345E-04 None 0 0 0
R/G 2501 Ig-14 57 rs781459488 0.8853 -1.736 1.0 D 0.732 0.495 0.577469734466 gnomAD-4.0.0 7.52513E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-04 1.65585E-05
R/L 2501 Ig-14 57 rs369559000 0.6813 -0.11 1.0 D 0.732 0.576 0.705191603356 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 5.45E-05 None 0 None 0 0 0
R/L 2501 Ig-14 57 rs369559000 0.6813 -0.11 1.0 D 0.732 0.576 0.705191603356 gnomAD-4.0.0 6.84104E-07 None None None None N None 0 0 None 0 2.52054E-05 None 0 0 0 0 0
R/Q 2501 Ig-14 57 rs369559000 0.3075 -0.599 1.0 N 0.733 0.345 None gnomAD-2.1.1 3.59E-05 None None None None N None 6.15E-05 1.15761E-04 None 0 0 None 0 None 0 3.53E-05 0
R/Q 2501 Ig-14 57 rs369559000 0.3075 -0.599 1.0 N 0.733 0.345 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
R/Q 2501 Ig-14 57 rs369559000 0.3075 -0.599 1.0 N 0.733 0.345 None gnomAD-4.0.0 4.15153E-05 None None None None N None 2.67051E-05 8.33778E-05 None 0 0 None 0 1.64366E-04 4.7459E-05 0 4.80138E-05
K/N 2588 Ig-15 56 rs1361032185 0.674 None 0.801 D 0.505 0.189 0.210429274316 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
K/N 2588 Ig-15 56 rs1361032185 0.674 None 0.801 D 0.505 0.189 0.210429274316 gnomAD-4.0.0 6.57142E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07211E-04 0
R/G 2675 Ig-16 55 rs375223745 0.4275 None 0.722 D 0.673 0.538 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/G 2675 Ig-16 55 rs375223745 0.4275 None 0.722 D 0.673 0.538 None gnomAD-4.0.0 2.56122E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78343E-06 0 0
R/S 2675 Ig-16 55 rs2154343309 0.4734 None 0.565 N 0.62 0.34 0.276482976112 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/F 2763 Ig-17 57 rs1231235466 0.2022 None 0.093 N 0.615 0.356 0.684933780128 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 6.07533E-05 0
K/R 2850 Ig-18 56 rs1396734796 0.1228 -1.068 0.999 N 0.625 0.331 0.341934017632 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/R 2850 Ig-18 56 rs1396734796 0.1228 -1.068 0.999 N 0.625 0.331 0.341934017632 gnomAD-4.0.0 1.59045E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
R/C 3113 Ig-21 56 rs751998418 0.4886 -1.249 1.0 D 0.75 0.684 None gnomAD-2.1.1 1.77E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.88E-05 0
R/C 3113 Ig-21 56 rs751998418 0.4886 -1.249 1.0 D 0.75 0.684 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
R/C 3113 Ig-21 56 rs751998418 0.4886 -1.249 1.0 D 0.75 0.684 None gnomAD-4.0.0 1.98273E-05 None None None None N None 0 0 None 3.37769E-05 0 None 0 0 2.62709E-05 0 0
R/H 3113 Ig-21 56 rs141258018 0.2111 -1.737 1.0 D 0.667 0.494 None gnomAD-2.1.1 4.78032E-04 None None None None N None 0 0 None 0 5.93681E-03 None 3.92029E-04 None 0 2.33E-05 2.77239E-04
R/H 3113 Ig-21 56 rs141258018 0.2111 -1.737 1.0 D 0.667 0.494 None gnomAD-3.1.2 3.22144E-04 None None None None N None 0 1.30941E-04 0 0 8.10498E-03 None 0 0 0 1.03777E-03 0
R/H 3113 Ig-21 56 rs141258018 0.2111 -1.737 1.0 D 0.667 0.494 None 1000 genomes 1.39776E-03 None None None None N None 0 0 None None 6E-03 0 None None None 1E-03 None
R/H 3113 Ig-21 56 rs141258018 0.2111 -1.737 1.0 D 0.667 0.494 None gnomAD-4.0.0 3.09165E-04 None None None None N None 1.33291E-05 3.33278E-05 None 0 9.36914E-03 None 0 1.64962E-04 1.35593E-05 5.38036E-04 1.59985E-04
R/S 3113 Ig-21 56 rs751998418 0.9182 None 0.996 N 0.66 0.639 0.557753153394 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.78469E-04
R/S 3113 Ig-21 56 rs751998418 0.9182 None 0.996 N 0.66 0.639 0.557753153394 gnomAD-4.0.0 6.57289E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 4.78469E-04
R/G 3204 Ig-22 58 None 0.909 None 0.975 D 0.677 0.531 0.558695339455 gnomAD-4.0.0 1.36819E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79866E-06 0 0
R/L 3204 Ig-22 58 None 0.8451 None 0.975 D 0.677 0.54 0.626127536812 gnomAD-4.0.0 6.84086E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99318E-07 0 0
R/Q 3204 Ig-22 58 rs775137389 0.2055 -0.872 0.997 N 0.633 0.305 None gnomAD-2.1.1 7.96E-06 None None None None N None 0 5.78E-05 None 0 0 None 0 None 0 0 0
R/Q 3204 Ig-22 58 rs775137389 0.2055 -0.872 0.997 N 0.633 0.305 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
R/Q 3204 Ig-22 58 rs775137389 0.2055 -0.872 0.997 N 0.633 0.305 None gnomAD-4.0.0 9.91338E-06 None None None None N None 1.33486E-05 1.66683E-05 None 0 1.33708E-04 None 0 0 5.93224E-06 0 1.60041E-05
T/A 3295 Ig-23 57 rs145053177 0.3095 -0.996 0.489 D 0.661 0.353 None gnomAD-2.1.1 2.12E-05 None None None None N None 2.40288E-04 0 None 0 0 None 0 None 0 0 0
T/A 3295 Ig-23 57 rs145053177 0.3095 -0.996 0.489 D 0.661 0.353 None gnomAD-3.1.2 2.63E-05 None None None None N None 9.66E-05 0 0 0 0 None 0 0 0 0 0
T/A 3295 Ig-23 57 rs145053177 0.3095 -0.996 0.489 D 0.661 0.353 None gnomAD-4.0.0 4.95672E-06 None None None None N None 1.06806E-04 0 None 0 0 None 0 0 0 0 0
T/M 3295 Ig-23 57 rs191708454 0.1915 -0.147 0.843 D 0.627 0.461 None gnomAD-2.1.1 2.54923E-04 None None None None N None 0 1.73561E-04 None 0 5.45E-05 None 1.79656E-03 None 0 1.76E-05 0
T/M 3295 Ig-23 57 rs191708454 0.1915 -0.147 0.843 D 0.627 0.461 None gnomAD-3.1.2 7.23E-05 None None None None N None 2.42E-05 6.55E-05 0 0 0 None 0 0 2.94E-05 1.24481E-03 4.78469E-04
T/M 3295 Ig-23 57 rs191708454 0.1915 -0.147 0.843 D 0.627 0.461 None 1000 genomes 3.99361E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 1E-03 None
T/M 3295 Ig-23 57 rs191708454 0.1915 -0.147 0.843 D 0.627 0.461 None gnomAD-4.0.0 1.08423E-04 None None None None N None 1.33326E-05 1.16647E-04 None 0 0 None 1.56167E-05 3.3036E-04 1.44068E-05 1.52626E-03 1.27992E-04
T/P 3295 Ig-23 57 rs145053177 0.9073 None 0.97 D 0.752 0.577 0.598497351524 gnomAD-4.0.0 6.84071E-07 None None None None N None 0 2.23624E-05 None 0 0 None 0 0 0 0 0
T/A 3995 Ig-28 58 None 0.107 None 0.011 D 0.393 0.189 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 3995 Ig-28 58 rs749320093 0.1658 0.069 0.002 D 0.405 0.141 None gnomAD-2.1.1 1.21E-05 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 1.78E-05 0
T/I 3995 Ig-28 58 rs749320093 0.1658 0.069 0.002 D 0.405 0.141 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 3995 Ig-28 58 rs749320093 0.1658 0.069 0.002 D 0.405 0.141 None gnomAD-4.0.0 6.81721E-06 None None None None N None 2.6698E-05 0 None 0 0 None 0 0 7.6282E-06 0 0
T/K 4660 Ig-29 55 rs754231728 0.1733 None 0.608 D 0.584 0.442 None gnomAD-4.0.0 6.8739E-07 None None None None N None 0 0 None 0 0 None 0 0 9.03251E-07 0 0
T/M 4660 Ig-29 55 rs754231728 0.0963 -0.129 0.328 D 0.556 0.382 None gnomAD-2.1.1 2.16E-05 None None None None N None 8.28E-05 0 None 0 0 None 0 None 0 3.15E-05 0
T/M 4660 Ig-29 55 rs754231728 0.0963 -0.129 0.328 D 0.556 0.382 None gnomAD-3.1.2 3.94E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 2.94E-05 0 0
T/M 4660 Ig-29 55 rs754231728 0.0963 -0.129 0.328 D 0.556 0.382 None gnomAD-4.0.0 9.95679E-06 None None None None N None 6.68717E-05 0 None 0 0 None 0 0 9.36062E-06 0 0
S/G 4756 Ig-30 57 None 0.1755 None 0.052 N 0.51 0.144 0.199424873507 gnomAD-4.0.0 3.18293E-06 None None None None N None 0 0 None 0 0 None 0 0 5.7167E-06 0 0
S/N 4756 Ig-30 57 None 0.1793 None 0.117 N 0.583 0.133 0.0297737177859 gnomAD-4.0.0 1.59145E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
S/T 4756 Ig-30 57 None 0.0616 None None N 0.289 0.147 0.0297737177859 gnomAD-4.0.0 1.59145E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85834E-06 0 0
I/S 4851 Ig-31 57 None 0.0889 None None N 0.333 0.169 0.269558022972 gnomAD-4.0.0 1.59117E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02389E-05
I/V 4851 Ig-31 57 rs1286288159 0.0684 None None N 0.133 0.065 0.353761421236 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 2.07125E-04 0
I/V 4851 Ig-31 57 rs1286288159 0.0684 None None N 0.133 0.065 0.353761421236 gnomAD-4.0.0 4.05984E-06 None None None None N None 0 0 None 0 0 None 0 0 3.61483E-06 4.69748E-05 0
T/A 4944 Ig-32 57 rs1479138931 0.0622 None 0.001 D 0.297 0.123 0.202949470691 gnomAD-4.0.0 1.02647E-05 None None None None N None 0 0 None 0 0 None 0 0 1.34926E-05 0 0
T/I 4944 Ig-32 57 None 0.0841 None None D 0.342 0.16 0.250579442822 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
I/T 5038 Ig-33 58 rs949151920 0.1532 None None N 0.351 0.162 0.533759884177 gnomAD-4.0.0 1.5913E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02407E-05
I/V 5038 Ig-33 58 rs2081160150 0.0548 None None N 0.127 0.107 0.233785782151 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
C/Y 5131 Ig-34 57 rs757766582 0.068 -1.126 None N 0.365 0.083 0.207176502487 gnomAD-2.1.1 7.14E-06 None None None None N None 4.13E-05 0 None 0 0 None 0 None 0 7.82E-06 0
C/Y 5131 Ig-34 57 rs757766582 0.068 -1.126 None N 0.365 0.083 0.207176502487 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
C/Y 5131 Ig-34 57 rs757766582 0.068 -1.126 None N 0.365 0.083 0.207176502487 gnomAD-4.0.0 5.12468E-06 None None None None N None 5.07374E-05 0 None 0 0 None 0 0 2.39318E-06 0 0
V/F 5224 Ig-35 57 rs773550460 0.0957 -1.312 None N 0.394 0.155 0.647529563541 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 0 None 1.85632E-04 0 1.65508E-04
V/F 5224 Ig-35 57 rs773550460 0.0957 -1.312 None N 0.394 0.155 0.647529563541 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.42E-05 0 0 0 0
V/F 5224 Ig-35 57 rs773550460 0.0957 -1.312 None N 0.394 0.155 0.647529563541 gnomAD-4.0.0 2.43391E-05 None None None None N None 0 0 None 0 0 None 2.8238E-04 0 0 0 2.84446E-05
V/G 5224 Ig-35 57 None 0.1366 None 0.055 N 0.462 0.107 0.58439663452 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
Q/E 5317 Ig-36 57 rs1210762968 0.1118 -1.363 0.425 N 0.359 0.135 0.281381271821 gnomAD-4.0.0 4.10532E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39678E-06 0 0
Q/P 5317 Ig-36 57 rs1230882379 0.9032 None 0.784 D 0.535 0.404 0.362960570912 gnomAD-4.0.0 3.18257E-06 None None None None N None 1.13084E-04 0 None 0 0 None 0 0 0 0 0
S/A 5506 Ig-38 57 None 0.09 None 0.863 N 0.53 0.254 0.294561560033 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
S/F 5506 Ig-38 57 rs201125295 0.1017 -0.871 0.964 D 0.637 0.396 None gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.45E-05 0
S/F 5506 Ig-38 57 rs201125295 0.1017 -0.871 0.964 D 0.637 0.396 None gnomAD-3.1.2 3.95E-05 None None None None N None 0 0 0 0 0 None 0 0 8.82E-05 0 0
S/F 5506 Ig-38 57 rs201125295 0.1017 -0.871 0.964 D 0.637 0.396 None gnomAD-4.0.0 4.89621E-05 None None None None N None 0 0 None 0 0 None 0 0 6.52684E-05 0 3.20266E-05
S/I 5693 Ig-40 57 rs1560804311 0.3171 0.826 0.976 N 0.682 0.406 0.737805688366 gnomAD-2.1.1 8.04E-06 None None None None N None 0 2.9E-05 None 0 0 None 3.27E-05 None 0 0 0
S/I 5693 Ig-40 57 rs1560804311 0.3171 0.826 0.976 N 0.682 0.406 0.737805688366 gnomAD-4.0.0 3.18242E-06 None None None None N None 0 2.28645E-05 None 0 0 None 0 0 0 1.43279E-05 0
S/R 5693 Ig-40 57 rs372588069 0.8009 -0.251 0.988 N 0.701 0.387 0.505946769237 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
S/R 5693 Ig-40 57 rs372588069 0.8009 -0.251 0.988 N 0.701 0.387 0.505946769237 gnomAD-4.0.0 1.3684E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79894E-06 0 0
S/G 5786 Ig-41 57 rs745386654 0.1561 -1.173 0.351 N 0.507 0.257 0.274366138417 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/G 5786 Ig-41 57 rs745386654 0.1561 -1.173 0.351 N 0.507 0.257 0.274366138417 gnomAD-4.0.0 6.84203E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
S/I 5786 Ig-41 57 rs1553924253 0.1933 None 0.007 N 0.533 0.41 0.445614145163 gnomAD-4.0.0 3.42102E-06 None None None None N None 0 0 None 0 7.55858E-05 None 0 0 1.79893E-06 0 0
S/R 5786 Ig-41 57 rs745386654 0.6699 0.097 0.655 N 0.686 0.408 0.322510055762 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
S/R 5786 Ig-41 57 rs745386654 0.6699 0.097 0.655 N 0.686 0.408 0.322510055762 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
S/R 5786 Ig-41 57 rs745386654 0.6699 0.097 0.655 N 0.686 0.408 0.322510055762 gnomAD-4.0.0 2.47875E-06 None None None None N None 5.33917E-05 0 None 0 0 None 0 0 0 0 0
I/K 5879 Ig-42 57 rs1560793812 0.4529 None 0.317 N 0.647 0.249 0.752220761769 gnomAD-4.0.0 6.84257E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15937E-05 0
F/V 5975 Ig-43 57 rs776879045 0.2774 -1.886 0.98 N 0.579 0.379 0.662754131768 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
F/V 5975 Ig-43 57 rs776879045 0.2774 -1.886 0.98 N 0.579 0.379 0.662754131768 gnomAD-4.0.0 1.59157E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85907E-06 0 0
S/T 6068 Ig-44 57 None 0.06 None 0.012 N 0.363 0.119 0.0884992946249 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 6162 Ig-45 58 rs367685188 0.0985 0.172 0.497 D 0.679 0.345 None gnomAD-2.1.1 1.07E-05 None None None None N None 1.24008E-04 0 None 0 0 None 0 None 0 0 0
T/I 6162 Ig-45 58 rs367685188 0.0985 0.172 0.497 D 0.679 0.345 None gnomAD-3.1.2 3.29E-05 None None None None N None 1.20616E-04 0 0 0 0 None 0 0 0 0 0
T/I 6162 Ig-45 58 rs367685188 0.0985 0.172 0.497 D 0.679 0.345 None gnomAD-4.0.0 6.0897E-06 None None None None N None 1.04822E-04 0 None 0 0 None 0 0 0 0 0
N/D 6255 Ig-46 57 rs2079983036 0.1202 None 0.007 N 0.399 0.079 0.139678290688 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
N/D 6255 Ig-46 57 rs2079983036 0.1202 None 0.007 N 0.399 0.079 0.139678290688 gnomAD-4.0.0 2.5627E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.67996E-05 0
N/K 6255 Ig-46 57 None 0.1561 None None N 0.261 0.099 0.0716867268079 gnomAD-4.0.0 6.8428E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99552E-07 0 0
T/K 6348 Ig-47 57 None 0.1453 None 0.062 N 0.53 0.346 0.406668915854 gnomAD-4.0.0 1.59304E-06 None None None None I None 0 2.29085E-05 None 0 0 None 0 0 0 0 0
S/P 6537 Ig-49 57 None 0.8613 None 0.782 N 0.709 0.507 0.367229591828 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
F/L 6630 Ig-50 57 rs1259557024 0.8499 -1.426 0.994 N 0.554 0.438 0.483741690565 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
F/L 6630 Ig-50 57 rs1259557024 0.8499 -1.426 0.994 N 0.554 0.438 0.483741690565 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.31044E-04 0 0 0 None 0 0 0 0 0
F/L 6630 Ig-50 57 rs1259557024 0.8499 -1.426 0.994 N 0.554 0.438 0.483741690565 gnomAD-4.0.0 5.12771E-06 None None None None N None 0 6.78012E-05 None 0 0 None 0 0 0 0 0
F/V 6630 Ig-50 57 rs1259557024 0.2268 None 0.994 N 0.573 0.546 0.793855663125 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07383E-04 0
F/V 6630 Ig-50 57 rs1259557024 0.2268 None 0.994 N 0.573 0.546 0.793855663125 gnomAD-4.0.0 2.56385E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.68161E-05 0
V/F 6724 Ig-51 58 rs140143513 0.1676 None 1.0 N 0.651 0.394 0.806643597941 gnomAD-4.0.0 6.84458E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99742E-07 0 0
V/I 6724 Ig-51 58 rs140143513 0.0795 -0.534 0.994 N 0.535 0.269 None gnomAD-2.1.1 1.79E-05 None None None None N None 1.24111E-04 0 None 0 5.13E-05 None 0 None 0 7.84E-06 0
V/I 6724 Ig-51 58 rs140143513 0.0795 -0.534 0.994 N 0.535 0.269 None gnomAD-3.1.2 4.6E-05 None None None None N None 7.24E-05 0 0 0 1.93274E-04 None 0 0 4.41E-05 0 0
V/I 6724 Ig-51 58 rs140143513 0.0795 -0.534 0.994 N 0.535 0.269 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
V/I 6724 Ig-51 58 rs140143513 0.0795 -0.534 0.994 N 0.535 0.269 None gnomAD-4.0.0 1.23981E-05 None None None None N None 5.33632E-05 0 None 0 6.69045E-05 None 0 0 6.78309E-06 2.19751E-05 4.8043E-05
S/G 6817 Ig-52 57 None 0.1401 None 0.913 N 0.551 0.334 0.468504517574 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/I 6817 Ig-52 57 rs757470877 0.2514 0.367 0.999 D 0.634 0.39 0.682950235808 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 9.95E-05 0 None 0 None 0 0 0
S/I 6817 Ig-52 57 rs757470877 0.2514 0.367 0.999 D 0.634 0.39 0.682950235808 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 8.65052E-04 0 None 0 0 0 0 0
S/I 6817 Ig-52 57 rs757470877 0.2514 0.367 0.999 D 0.634 0.39 0.682950235808 gnomAD-4.0.0 8.97424E-06 None None None None N None 0 0 None 2.86509E-04 0 None 0 0 0 0 0
T/A 6911 Ig-53 58 None 0.0858 None 0.996 N 0.454 0.511 0.489728331402 gnomAD-4.0.0 1.59258E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02663E-05
T/P 6911 Ig-53 58 None 0.8386 None 1.0 D 0.752 0.686 0.581280949539 gnomAD-4.0.0 3.18516E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72076E-06 0 0
S/F 7004 Ig-54 57 None 0.2425 None 0.484 D 0.619 0.347 0.631438196984 gnomAD-4.0.0 6.84325E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99591E-07 0 0
S/Y 7004 Ig-54 57 None 0.2264 None 0.484 D 0.612 0.36 0.636706105328 gnomAD-4.0.0 6.84325E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65717E-05
T/I 7100 Ig-55 57 None 0.1012 None 0.002 N 0.409 0.335 0.384419519794 gnomAD-4.0.0 3.18371E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71912E-06 0 0
I/V 7286 Ig-57 57 rs1434099856 0.1212 None 0.219 N 0.247 0.065 0.420199648628 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 7286 Ig-57 57 rs1434099856 0.1212 None 0.219 N 0.247 0.065 0.420199648628 gnomAD-4.0.0 2.56307E-06 None None None None N None 0 0 None 0 0 None 1.56961E-05 0 2.39389E-06 0 0
T/A 7379 Ig-58 57 None 0.0927 None 0.704 N 0.379 0.267 0.295974979623 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 7475 Ig-59 57 None 0.0999 None 0.206 D 0.398 0.295 0.176091768786 gnomAD-4.0.0 1.59232E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86002E-06 0 0
T/S 7475 Ig-59 57 None 0.1186 None 0.007 N 0.257 0.163 0.134241683229 gnomAD-4.0.0 1.59236E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02737E-05
H/P 7571 Ig-60 57 rs776085388 0.8787 -0.563 0.994 N 0.569 0.432 0.547426921019 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
H/P 7571 Ig-60 57 rs776085388 0.8787 -0.563 0.994 N 0.569 0.432 0.547426921019 gnomAD-4.0.0 1.59188E-06 None None None None N None 0 2.28666E-05 None 0 0 None 0 0 0 0 0
H/Y 7571 Ig-60 57 rs1483207603 0.134 0.622 0.998 N 0.492 0.355 0.413113201963 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
H/Y 7571 Ig-60 57 rs1483207603 0.134 0.622 0.998 N 0.492 0.355 0.413113201963 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
H/Y 7571 Ig-60 57 rs1483207603 0.134 0.622 0.998 N 0.492 0.355 0.413113201963 gnomAD-4.0.0 6.5722E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47016E-05 0 0
L/F 7665 Ig-61 58 None 0.0825 None 0.055 N 0.449 0.118 0.418095516054 gnomAD-4.0.0 1.59249E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43353E-05 0
S/N 7758 Ig-62 57 rs1464026759 0.2827 -0.969 0.417 N 0.593 0.176 0.236890367714 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
S/N 7758 Ig-62 57 rs1464026759 0.2827 -0.969 0.417 N 0.593 0.176 0.236890367714 gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
S/N 7758 Ig-62 57 rs1464026759 0.2827 -0.969 0.417 N 0.593 0.176 0.236890367714 gnomAD-4.0.0 4.33825E-06 None None None None N None 4.00491E-05 0 None 0 0 None 0 0 2.54305E-06 0 1.60128E-05
S/R 7758 Ig-62 57 rs1402117670 0.7013 -0.498 0.688 N 0.564 0.293 0.339074221408 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
S/R 7758 Ig-62 57 rs1402117670 0.7013 -0.498 0.688 N 0.564 0.293 0.339074221408 gnomAD-4.0.0 4.78991E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99546E-07 5.79737E-05 1.65684E-05
T/A 7852 Ig-63 58 None 0.0944 None None D 0.202 0.202 0.230578612272 gnomAD-4.0.0 2.05273E-06 None None None None N None 0 0 None 0 2.51965E-05 None 0 0 8.99522E-07 1.15937E-05 0
T/I 7852 Ig-63 58 rs1183659807 0.1519 None 0.001 N 0.325 0.264 0.465633601861 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
T/I 7852 Ig-63 58 rs1183659807 0.1519 None 0.001 N 0.325 0.264 0.465633601861 gnomAD-4.0.0 3.71838E-06 None None None None N None 0 1.66706E-05 None 0 0 None 0 0 4.23831E-06 0 0
S/C 7945 Ig-64 57 rs867642789 0.1105 None 0.013 N 0.372 0.346 0.37281450598 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93573E-04 None 0 0 0 0 0
S/C 7945 Ig-64 57 rs867642789 0.1105 None 0.013 N 0.372 0.346 0.37281450598 gnomAD-4.0.0 2.30631E-05 None None None None N None 0 0 None 0 4.36533E-04 None 0 0 0 0 0
T/A 8041 Ig-65 57 None 0.0751 None 0.002 N 0.189 0.241 0.209622950755 gnomAD-4.0.0 6.84205E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9948E-07 0 0
T/S 8041 Ig-65 57 None 0.0885 None 0.065 N 0.254 0.169 0.166414681773 gnomAD-4.0.0 6.84205E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9948E-07 0 0
I/M 8227 Ig-67 57 rs1300167182 0.222 -1.305 0.994 N 0.561 0.353 0.498513350342 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.67E-05 0
I/M 8227 Ig-67 57 rs1300167182 0.222 -1.305 0.994 N 0.561 0.353 0.498513350342 gnomAD-3.1.2 1.97E-05 None None None None I None 0 6.55E-05 0 0 0 None 0 0 2.94E-05 0 0
I/M 8227 Ig-67 57 rs1300167182 0.222 -1.305 0.994 N 0.561 0.353 0.498513350342 gnomAD-4.0.0 8.67628E-06 None None None None I None 0 1.667E-05 None 0 0 None 0 0 1.10194E-05 0 0
S/C 8320 Ig-68 57 rs1374151646 0.1115 None 0.955 D 0.689 0.368 0.541285430251 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 3.16456E-03 1.47E-05 0 0
S/C 8320 Ig-68 57 rs1374151646 0.1115 None 0.955 D 0.689 0.368 0.541285430251 gnomAD-4.0.0 1.31377E-05 None None None None N None 0 0 None 0 0 None 0 3.40136E-03 1.47059E-05 0 0
S/F 8320 Ig-68 57 rs1374151646 0.1479 -0.508 0.988 N 0.753 0.4 0.732106347842 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.65782E-04
S/F 8320 Ig-68 57 rs1374151646 0.1479 -0.508 0.988 N 0.753 0.4 0.732106347842 gnomAD-4.0.0 4.77415E-06 None None None None N None 0 0 None 0 0 None 0 2.41196E-04 2.85868E-06 0 3.02371E-05
T/I 8416 Ig-69 57 rs794729631 0.1418 0.258 0.225 D 0.366 0.393 0.464270400615 gnomAD-2.1.1 1.08E-05 None None None None N None 8.29E-05 0 None 0 0 None 3.28E-05 None 0 0 0
T/I 8416 Ig-69 57 rs794729631 0.1418 0.258 0.225 D 0.366 0.393 0.464270400615 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 8416 Ig-69 57 rs794729631 0.1418 0.258 0.225 D 0.366 0.393 0.464270400615 gnomAD-4.0.0 5.12746E-06 None None None None N None 5.0758E-05 0 None 0 0 None 0 0 0 1.34174E-05 0
T/I 8512 Ig-70 57 rs764620561 0.1161 0.193 0.995 N 0.677 0.446 0.452450644169 gnomAD-2.1.1 7.14E-06 None None None None N None 0 2.83E-05 None 0 0 None 0 None 0 7.81E-06 0
T/I 8512 Ig-70 57 rs764620561 0.1161 0.193 0.995 N 0.677 0.446 0.452450644169 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 8512 Ig-70 57 rs764620561 0.1161 0.193 0.995 N 0.677 0.446 0.452450644169 gnomAD-4.0.0 3.71849E-06 None None None None N None 0 1.66711E-05 None 0 0 None 0 0 2.54308E-06 0 3.20338E-05
V/G 8606 Ig-71 58 rs747173071 0.3193 -2.934 0.91 N 0.714 0.362 0.851354784354 gnomAD-2.1.1 8.04E-06 None None None None N None 6.46E-05 0 None 0 0 None 3.27E-05 None 0 0 0
V/G 8606 Ig-71 58 rs747173071 0.3193 -2.934 0.91 N 0.714 0.362 0.851354784354 gnomAD-4.0.0 1.59157E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
V/L 8606 Ig-71 58 None 0.1374 None 0.005 N 0.49 0.099 0.366466682447 gnomAD-4.0.0 6.84269E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99544E-07 0 0
V/M 8606 Ig-71 58 rs1453874617 0.0983 -0.724 0.664 N 0.647 0.308 0.490419987736 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
V/M 8606 Ig-71 58 rs1453874617 0.0983 -0.724 0.664 N 0.647 0.308 0.490419987736 gnomAD-4.0.0 6.84269E-07 None None None None N None 0 0 None 0 2.51965E-05 None 0 0 0 0 0
S/G 8699 Ig-72 57 rs1164228016 0.1623 -1.397 0.998 N 0.573 0.462 0.457286136841 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/G 8699 Ig-72 57 rs1164228016 0.1623 -1.397 0.998 N 0.573 0.462 0.457286136841 gnomAD-4.0.0 1.59143E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43295E-05 0
S/N 8699 Ig-72 57 rs1311071697 0.3313 None 0.973 D 0.59 0.22 None gnomAD-4.0.0 1.23162E-05 None None None None N None 0 0 None 0 0 None 0 0 1.61914E-05 0 0
T/A 8793 Ig-73 58 rs776154251 0.0765 -1.493 0.001 D 0.28 0.241 0.255270683199 gnomAD-2.1.1 5.37E-05 None None None None N None 0 0 None 0 0 None 0 None 5.59642E-04 7.85E-06 0
T/A 8793 Ig-73 58 rs776154251 0.0765 -1.493 0.001 D 0.28 0.241 0.255270683199 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 1.88324E-04 0 1.47E-05 0 0
T/A 8793 Ig-73 58 rs776154251 0.0765 -1.493 0.001 D 0.28 0.241 0.255270683199 gnomAD-4.0.0 1.54926E-05 None None None None N None 0 0 None 0 0 None 2.96856E-04 0 5.08581E-06 0 0
G/D 8886 Ig-74 57 None 0.4367 None 0.801 N 0.683 0.299 0.261217442401 gnomAD-4.0.0 2.40069E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62506E-06 0 0
G/S 8886 Ig-74 57 rs72648991 0.0782 -1.142 0.233 N 0.269 0.188 0.156986980423 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
G/S 8886 Ig-74 57 rs72648991 0.0782 -1.142 0.233 N 0.269 0.188 0.156986980423 gnomAD-4.0.0 2.2582E-05 None None None None N None 0 0 None 0 0 None 0 1.7337E-04 2.69863E-05 1.1598E-05 1.65711E-05
A/D 8982 Ig-75 57 rs1171558626 0.3748 -2.502 0.175 D 0.66 0.288 0.557207555769 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
A/D 8982 Ig-75 57 rs1171558626 0.3748 -2.502 0.175 D 0.66 0.288 0.557207555769 gnomAD-4.0.0 1.59144E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43299E-05 0
A/T 8982 Ig-75 57 rs1384345252 0.0718 None 0.001 N 0.183 0.069 0.211220785272 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
A/T 8982 Ig-75 57 rs1384345252 0.0718 None 0.001 N 0.183 0.069 0.211220785272 gnomAD-4.0.0 6.19726E-06 None None None None N None 0 0 None 0 0 None 0 0 8.47629E-06 0 0
E/K 9075 Ig-76 57 rs1560584120 0.1367 None 0.801 N 0.554 0.238 0.348983352498 gnomAD-4.0.0 1.36846E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79895E-06 0 0
T/A 9261 Ig-78 57 None 0.0987 None 0.625 D 0.45 0.295 0.255777322467 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 9357 Ig-79 57 None 0.0982 None 0.625 None 0.52 0.238 0.290222751274 gnomAD-4.0.0 6.8418E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
T/I 9357 Ig-79 57 rs144930507 0.1411 0.159 0.012 None 0.379 0.289 None gnomAD-2.1.1 5.45707E-04 None None None None N None 6.11924E-03 1.41371E-04 None 0 0 None 0 None 0 0 0
T/I 9357 Ig-79 57 rs144930507 0.1411 0.159 0.012 None 0.379 0.289 None gnomAD-3.1.2 1.80762E-03 None None None None N None 5.98947E-03 1.50721E-03 0 0 0 None 0 0 0 0 1.91205E-03
T/I 9357 Ig-79 57 rs144930507 0.1411 0.159 0.012 None 0.379 0.289 None 1000 genomes 2.39617E-03 None None None None N None 8.3E-03 1.4E-03 None None 0 0 None None None 0 None
T/I 9357 Ig-79 57 rs144930507 0.1411 0.159 0.012 None 0.379 0.289 None gnomAD-4.0.0 3.20352E-04 None None None None N None 5.97317E-03 6.33312E-04 None 0 0 None 0 1.65071E-04 2.54279E-06 0 4.32097E-04
T/P 9357 Ig-79 57 None 0.7624 None 0.989 None 0.577 0.614 0.630113592811 gnomAD-4.0.0 6.8418E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99457E-07 0 0
H/Q 9453 Ig-80 57 None 0.2054 None 0.007 None 0.371 0.08 0.26547132957 gnomAD-4.0.0 6.84184E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99433E-07 0 0
V/L 9550 Ig-81 58 rs879094573 0.0537 -0.325 None None 0.152 0.129 0.367803931526 gnomAD-2.1.1 4.01E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
V/L 9550 Ig-81 58 rs879094573 0.0537 -0.325 None None 0.152 0.129 0.367803931526 gnomAD-4.0.0 2.05252E-06 None None None None N None 0 4.47247E-05 None 0 0 None 0 0 8.99437E-07 0 0
V/M 9550 Ig-81 58 rs879094573 0.0795 None 0.093 None 0.537 0.144 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/M 9550 Ig-81 58 rs879094573 0.0795 None 0.093 None 0.537 0.144 None gnomAD-4.0.0 6.19653E-06 None None None None N None 0 0 None 0 0 None 0 0 8.47574E-06 0 0
V/I 9646 Ig-82 57 rs765109515 0.0693 -0.319 None None 0.181 0.117 0.402471007487 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
V/I 9646 Ig-82 57 rs765109515 0.0693 -0.319 None None 0.181 0.117 0.402471007487 gnomAD-4.0.0 3.1824E-06 None None None None N None 5.65227E-05 0 None 0 0 None 0 0 2.85789E-06 0 0
V/L 9646 Ig-82 57 rs765109515 0.1102 -0.322 None None 0.151 0.143 0.336892272479 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.43E-05 0
V/L 9646 Ig-82 57 rs765109515 0.1102 -0.322 None None 0.151 0.143 0.336892272479 gnomAD-4.0.0 1.75032E-05 None None None None N None 0 0 None 0 0 None 1.88324E-05 0 2.85789E-05 0 0
K/Q 9755 Ig-83 58 None 0.2858 None 0.999 None 0.627 0.276 0.374255764437 gnomAD-4.0.0 1.59098E-06 None None None None N None 5.65355E-05 0 None 0 0 None 0 0 0 0 0
T/I 9957 Ig-84 58 rs2154291224 0.0904 None None None 0.411 0.098 0.266843984389 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
K/E 13742 Ig-87 59 None 0.9735 None 0.999 N 0.583 0.403 0.433713641954 gnomAD-4.0.0 1.59195E-06 None None None None N None 0 2.28686E-05 None 0 0 None 0 0 0 0 0
A/S 13836 Ig-88 57 rs1326857970 0.1733 -1.74 0.007 N 0.302 0.042 0.0986583533028 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
A/S 13836 Ig-88 57 rs1326857970 0.1733 -1.74 0.007 N 0.302 0.042 0.0986583533028 gnomAD-4.0.0 1.59232E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86002E-06 0 0
Y/C 13931 Ig-89 56 None 0.18 None 0.257 N 0.487 0.085 0.0482279557977 gnomAD-4.0.0 1.38395E-06 None None None None N None 3.0021E-05 0 None 0 0 None 0 0 9.06918E-07 0 0
Y/H 13931 Ig-89 56 rs1162801145 0.1274 -1.606 None N 0.171 0.057 0.0762999501168 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
Y/H 13931 Ig-89 56 rs1162801145 0.1274 -1.606 None N 0.171 0.057 0.0762999501168 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Y/H 13931 Ig-89 56 rs1162801145 0.1274 -1.606 None N 0.171 0.057 0.0762999501168 gnomAD-4.0.0 6.57488E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47111E-05 0 0
I/F 14108 Ig-91 55 rs772414514 0.4094 -1.698 0.627 N 0.645 0.226 0.576639666579 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 0 0
I/F 14108 Ig-91 55 rs772414514 0.4094 -1.698 0.627 N 0.645 0.226 0.576639666579 gnomAD-4.0.0 6.15989E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.04367E-04 0
I/N 14108 Ig-91 55 None 0.8458 None 0.773 N 0.679 0.341 0.769439331453 gnomAD-4.0.0 6.84434E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99675E-07 0 0
K/N 14197 Ig-92 56 None 0.6145 None 0.003 D 0.268 0.088 0.165133752707 gnomAD-4.0.0 6.8435E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99625E-07 0 0
I/F 14285 Ig-93 55 None 0.1663 None 0.998 N 0.533 0.225 0.533614126537 gnomAD-4.0.0 1.59229E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8595E-06 0 0
I/M 14285 Ig-93 55 rs761517606 0.1291 None 0.998 N 0.531 0.224 0.471700387322 gnomAD-4.0.0 1.3688E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79918E-06 0 0
I/N 14285 Ig-93 55 None 0.2539 None 0.988 N 0.62 0.261 0.833390104951 gnomAD-4.0.0 1.36879E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79918E-06 0 0
I/V 14285 Ig-93 55 rs771436214 0.1083 -1.479 0.906 N 0.453 0.108 0.597979452267 gnomAD-2.1.1 1.21E-05 None None None None N None 0 8.7E-05 None 0 0 None 0 None 0 0 0
I/V 14285 Ig-93 55 rs771436214 0.1083 -1.479 0.906 N 0.453 0.108 0.597979452267 gnomAD-4.0.0 4.77686E-06 None None None None N None 0 6.86405E-05 None 0 0 None 0 0 0 0 0
I/V 14374 Ig-94 56 rs754227553 0.0707 -1.825 None N 0.249 0.041 0.139678290688 gnomAD-2.1.1 2.42E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 4.46E-05 0
I/V 14374 Ig-94 56 rs754227553 0.0707 -1.825 None N 0.249 0.041 0.139678290688 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
I/V 14374 Ig-94 56 rs754227553 0.0707 -1.825 None N 0.249 0.041 0.139678290688 gnomAD-4.0.0 2.72783E-05 None None None None N None 1.33551E-05 1.66795E-05 None 0 0 None 0 0 3.47631E-05 0 1.60195E-05
S/A 14552 Ig-96 56 None 0.1015 None 0.01 N 0.235 0.13 0.252162846088 gnomAD-4.0.0 6.86782E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01622E-07 0 0
S/L 14552 Ig-96 56 rs1454698596 0.1312 None 0.676 N 0.525 0.255 0.404733080969 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
S/L 14552 Ig-96 56 rs1454698596 0.1312 None 0.676 N 0.525 0.255 0.404733080969 gnomAD-4.0.0 3.73242E-06 None None None None N None 2.67516E-05 0 None 3.40391E-05 0 None 0 0 1.69959E-06 0 1.60684E-05
S/P 14552 Ig-96 56 None 0.958 None 0.784 N 0.604 0.367 0.408714661073 gnomAD-4.0.0 1.37356E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80324E-06 0 0
M/I 14641 Ig-97 56 rs2059746985 0.1886 None None N 0.173 0.137 0.298056030225 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/I 14641 Ig-97 56 rs2059746985 0.1886 None None N 0.173 0.137 0.298056030225 gnomAD-4.0.0 6.57557E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47076E-05 0 0
M/K 14641 Ig-97 56 rs1481001987 0.2734 -1.532 0.055 N 0.535 0.272 0.57047621783 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
M/K 14641 Ig-97 56 rs1481001987 0.2734 -1.532 0.055 N 0.535 0.272 0.57047621783 gnomAD-4.0.0 1.59229E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85951E-06 0 0
M/R 14641 Ig-97 56 None 0.2875 None 0.106 N 0.573 0.292 0.579790155161 gnomAD-4.0.0 1.59229E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85951E-06 0 0
M/V 14641 Ig-97 56 None 0.1105 None None N 0.157 0.107 0.410734915765 gnomAD-4.0.0 2.05318E-06 None None None None N None 2.98954E-05 0 None 0 0 None 0 0 1.79919E-06 0 0
S/F 14730 Ig-98 56 None 0.0483 None None N 0.283 0.046 0.210429274316 gnomAD-4.0.0 1.59593E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86302E-06 0 0
T/I 14819 Ig-99 55 rs778014249 0.1848 0.352 0.901 N 0.663 0.446 0.563619085548 gnomAD-2.1.1 8.18E-05 None None None None N None 0 0 None 0 0 None 0 None 6.142E-04 4.96E-05 0
T/I 14819 Ig-99 55 rs778014249 0.1848 0.352 0.901 N 0.663 0.446 0.563619085548 gnomAD-3.1.2 5.93E-05 None None None None N None 0 0 0 0 0 None 4.71609E-04 0 5.89E-05 0 0
T/I 14819 Ig-99 55 rs778014249 0.1848 0.352 0.901 N 0.663 0.446 0.563619085548 gnomAD-4.0.0 3.46377E-05 None None None None N None 0 0 None 0 0 None 4.88651E-04 1.66556E-04 1.87957E-05 0 1.62771E-05
I/V 14997 Ig-101 56 rs1437722307 0.1785 -1.601 0.4 N 0.265 0.076 0.575180444326 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
I/V 14997 Ig-101 56 rs1437722307 0.1785 -1.601 0.4 N 0.265 0.076 0.575180444326 gnomAD-4.0.0 1.59532E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43451E-05 0
I/V 15086 Ig-102 56 None 0.1176 None 0.141 N 0.444 0.116 0.542630587416 gnomAD-4.0.0 1.59385E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86292E-06 0 0
V/A 15175 Ig-103 56 rs773388033 0.2917 -2.059 0.027 N 0.445 0.073 0.34854441366 gnomAD-2.1.1 7.17E-06 None None None None N None 4.14E-05 0 None 0 0 None 3.27E-05 None 0 0 0
V/A 15175 Ig-103 56 rs773388033 0.2917 -2.059 0.027 N 0.445 0.073 0.34854441366 gnomAD-3.1.2 6.59E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
V/A 15175 Ig-103 56 rs773388033 0.2917 -2.059 0.027 N 0.445 0.073 0.34854441366 gnomAD-4.0.0 1.24049E-06 None None None None N None 1.33772E-05 0 None 0 0 None 0 0 0 1.09859E-05 0
V/F 15175 Ig-103 56 rs1331081266 0.1876 None 0.317 N 0.619 0.129 0.31411915649 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/F 15175 Ig-103 56 rs1331081266 0.1876 None 0.317 N 0.619 0.129 0.31411915649 gnomAD-4.0.0 6.58796E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47332E-05 0 0
V/I 15175 Ig-103 56 rs1331081266 0.0703 -0.275 None N 0.229 0.109 0.0920862733494 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.64E-05 None 0 None 0 0 0
V/I 15175 Ig-103 56 rs1331081266 0.0703 -0.275 None N 0.229 0.109 0.0920862733494 gnomAD-4.0.0 1.59387E-06 None None None None N None 0 0 None 0 2.78909E-05 None 0 0 0 0 0
T/N 15263 Ig-104 56 rs1198734931 0.3354 -1.429 0.338 N 0.588 0.351 0.42130639912 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
T/N 15263 Ig-104 56 rs1198734931 0.3354 -1.429 0.338 N 0.588 0.351 0.42130639912 gnomAD-3.1.2 1.32E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 1.47E-05 0 0
T/N 15263 Ig-104 56 rs1198734931 0.3354 -1.429 0.338 N 0.588 0.351 0.42130639912 gnomAD-4.0.0 3.10064E-06 None None None None N None 1.33722E-05 0 None 0 2.23404E-05 None 0 0 1.69612E-06 0 1.60282E-05
M/I 15357 Ig-105 56 None 0.2392 None None N 0.231 0.104 0.206339911435 gnomAD-4.0.0 6.84779E-07 None None None None N None 0 0 None 0 2.52589E-05 None 0 0 0 0 0
R/Q 15535 Ig-107 56 rs761015674 0.1741 -0.641 1.0 N 0.698 0.397 0.376039117802 gnomAD-2.1.1 2.02E-05 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 2.68E-05 0
R/Q 15535 Ig-107 56 rs761015674 0.1741 -0.641 1.0 N 0.698 0.397 0.376039117802 gnomAD-4.0.0 1.36449E-05 None None None None N None 4.00588E-05 0 None 0 0 None 0 0 1.3572E-05 2.19732E-05 1.60246E-05
S/A 15621 Ig-108 54 None 0.077 None 0.454 N 0.438 0.153 0.307648195649 gnomAD-4.0.0 1.59483E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86428E-06 0 0
E/A 16019 Ig-109 52 None 0.2841 None 0.977 D 0.559 0.442 0.509820907775 gnomAD-4.0.0 3.18685E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72413E-06 0 0
E/K 16019 Ig-109 52 rs758399903 0.2191 -1.281 0.992 N 0.517 0.291 0.45563089846 gnomAD-2.1.1 4.85E-05 None None None None N None 0 2.9E-05 None 0 5.61E-05 None 2.28818E-04 None 0 2.69E-05 0
E/K 16019 Ig-109 52 rs758399903 0.2191 -1.281 0.992 N 0.517 0.291 0.45563089846 gnomAD-3.1.2 1.98E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 1.47E-05 2.07641E-04 0
E/K 16019 Ig-109 52 rs758399903 0.2191 -1.281 0.992 N 0.517 0.291 0.45563089846 gnomAD-4.0.0 2.29462E-05 None None None None N None 1.33761E-05 1.66978E-05 None 0 2.23724E-05 None 0 0 1.27207E-05 1.97707E-04 1.60282E-05
T/P 16315 Ig-110 54 rs760198616 0.883 -0.532 0.997 D 0.621 0.698 0.513503867364 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
T/P 16315 Ig-110 54 rs760198616 0.883 -0.532 0.997 D 0.621 0.698 0.513503867364 gnomAD-4.0.0 2.05414E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.47955E-05 0
H/N 17011 Ig-111 57 rs1471950857 0.1006 -0.81 0.001 N 0.193 0.121 0.173771789658 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
H/N 17011 Ig-111 57 rs1471950857 0.1006 -0.81 0.001 N 0.193 0.121 0.173771789658 gnomAD-4.0.0 1.59326E-06 None None None None N None 0 2.28833E-05 None 0 0 None 0 0 0 0 0
Q/H 17333 Ig-112 83 None 0.1433 None 0.196 N 0.469 0.083 0.247872288689 gnomAD-4.0.0 1.60681E-06 None None None None N None 0 0 None 0 0 None 0 0 2.88317E-06 0 0
Q/P 17333 Ig-112 83 None 0.7914 None 0.065 N 0.572 0.267 0.301122078929 gnomAD-4.0.0 5.49847E-06 None None None None N None 0 0 None 0 0 None 0 0 6.31697E-06 1.1714E-05 0
E/K 17728 Ig-113 52 None 0.3928 None 0.055 N 0.379 0.26 0.236890367714 gnomAD-4.0.0 6.84391E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.6575E-05
E/K 18029 Ig-114 62 None 0.1929 None 0.061 N 0.279 0.2 0.223146558224 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 18748 Ig-116 61 rs1411214740 0.1968 None 0.999 D 0.743 0.624 0.518312163451 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.9425E-04 None 0 0 0 0 0
T/I 18748 Ig-116 61 rs1411214740 0.1968 None 0.999 D 0.743 0.624 0.518312163451 gnomAD-4.0.0 4.34004E-06 None None None None N None 1.33601E-05 0 None 0 8.93256E-05 None 0 0 8.4791E-07 0 1.60174E-05
T/S 18748 Ig-116 61 rs1411214740 0.129 -1.354 0.825 N 0.391 0.346 0.273938319068 gnomAD-2.1.1 4.03E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
T/S 18748 Ig-116 61 rs1411214740 0.129 -1.354 0.825 N 0.391 0.346 0.273938319068 gnomAD-4.0.0 6.8452E-07 None None None None N None 2.99186E-05 0 None 0 0 None 0 0 0 0 0
S/F 19147 Ig-117 53 rs1178386765 0.5984 None 1.0 D 0.78 0.457 0.832794028055 gnomAD-4.0.0 6.8441E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99635E-07 0 0
A/S 19443 Ig-118 53 None 0.074 None None N 0.139 0.105 0.163833314356 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
A/T 19443 Ig-118 53 None 0.0675 None 0.001 N 0.204 0.072 0.201204373187 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
A/V 19443 Ig-118 53 rs1360001030 0.0939 1.206 0.193 N 0.517 0.142 0.348324211639 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
A/V 19443 Ig-118 53 rs1360001030 0.0939 1.206 0.193 N 0.517 0.142 0.348324211639 gnomAD-4.0.0 1.59184E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43295E-05 0
V/A 20135 Ig-120 56 None 0.3314 None 0.998 N 0.543 0.327 0.666230076168 gnomAD-4.0.0 1.59217E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8602E-06 0 0
V/I 20135 Ig-120 56 None 0.0735 None 0.767 N 0.373 0.23 0.573918482621 gnomAD-4.0.0 2.05317E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79933E-06 1.16007E-05 0
E/K 20533 Ig-121 55 rs970448292 0.5587 -1.269 0.669 N 0.51 0.278 0.251116650651 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
E/K 20533 Ig-121 55 rs970448292 0.5587 -1.269 0.669 N 0.51 0.278 0.251116650651 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/K 20533 Ig-121 55 rs970448292 0.5587 -1.269 0.669 N 0.51 0.278 0.251116650651 gnomAD-4.0.0 1.23986E-06 None None None None N None 2.67187E-05 0 None 0 0 None 0 0 0 0 0
E/Q 20533 Ig-121 55 rs970448292 0.2431 None 0.136 N 0.386 0.252 0.20549828249 gnomAD-4.0.0 1.36886E-06 None None None None N None 0 0 None 0 0 None 0 0 8.9968E-07 0 1.657E-05
K/E 20828 Ig-122 60 rs2154183659 0.2316 None 0.716 N 0.495 0.308 0.330331372229 gnomAD-4.0.0 3.18368E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85922E-06 0 3.02499E-05
K/T 20828 Ig-122 60 None 0.0858 None 0.946 N 0.681 0.328 0.306695030598 gnomAD-4.0.0 1.59184E-06 None None None None N None 5.65803E-05 0 None 0 0 None 0 0 0 0 0
I/V 21523 Ig-124 55 rs761550336 0.0605 -1.269 None N 0.117 0.16 0.246215685461 gnomAD-2.1.1 8.06E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
I/V 21523 Ig-124 55 rs761550336 0.0605 -1.269 None N 0.117 0.16 0.246215685461 gnomAD-4.0.0 1.11455E-05 None None None None I None 0 0 None 0 0 None 0 0 2.86044E-06 7.16764E-05 3.02663E-05
T/I 21920 Ig-125 55 None 0.1735 None 0.001 N 0.287 0.255 0.26547132957 gnomAD-4.0.0 1.59705E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43868E-05 0
F/L 22318 Ig-126 54 rs1282369228 0.827 -1.529 0.003 N 0.133 0.239 0.450441870249 gnomAD-2.1.1 8.06E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
F/L 22318 Ig-126 54 rs1282369228 0.827 -1.529 0.003 N 0.133 0.239 0.450441870249 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
F/L 22318 Ig-126 54 rs1282369228 0.827 -1.529 0.003 N 0.133 0.239 0.450441870249 gnomAD-4.0.0 3.09963E-06 None None None None N None 1.33572E-05 3.33556E-05 None 0 0 None 0 0 0 0 3.20369E-05
F/S 22318 Ig-126 54 None 0.4463 None 0.028 N 0.361 0.356 0.534907319155 gnomAD-4.0.0 4.77734E-06 None None None None N None 0 0 None 0 0 None 0 0 8.58109E-06 0 0
T/I 22607 Ig-127 48 rs771603862 0.2069 0.046 0.1 N 0.413 0.302 0.474010150167 gnomAD-2.1.1 4.83E-05 None None None None N None 0 0 None 0 0 None 2.94137E-04 None 0 2.67E-05 0
T/I 22607 Ig-127 48 rs771603862 0.2069 0.046 0.1 N 0.413 0.302 0.474010150167 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 6.22407E-04 0
T/I 22607 Ig-127 48 rs771603862 0.2069 0.046 0.1 N 0.413 0.302 0.474010150167 gnomAD-4.0.0 2.41736E-05 None None None None N None 0 0 None 0 0 None 0 0 9.3254E-06 2.85513E-04 3.20318E-05
M/R 23004 Ig-128 55 None 0.1314 None None N 0.188 0.344 0.315903272564 gnomAD-4.0.0 1.59207E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85969E-06 0 0
M/V 23004 Ig-128 55 rs1257560836 0.0726 -0.513 None N 0.116 0.176 0.281780670237 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
M/V 23004 Ig-128 55 rs1257560836 0.0726 -0.513 None N 0.116 0.176 0.281780670237 gnomAD-4.0.0 1.36872E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99611E-07 1.1595E-05 0
I/T 23690 Ig-130 54 rs752065044 0.2095 -2.717 0.892 N 0.617 0.395 0.692093607395 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/T 23690 Ig-130 54 rs752065044 0.2095 -2.717 0.892 N 0.617 0.395 0.692093607395 gnomAD-4.0.0 1.59209E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43295E-05 0
L/P 24483 Ig-132 53 None 0.991 None 0.939 N 0.63 0.442 0.679888000648 gnomAD-4.0.0 1.59264E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43394E-05 0
L/R 24483 Ig-132 53 rs1226073003 0.5105 -1.674 0.884 N 0.595 0.353 0.629781192331 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
L/R 24483 Ig-132 53 rs1226073003 0.5105 -1.674 0.884 N 0.595 0.353 0.629781192331 gnomAD-4.0.0 1.59264E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43394E-05 0
S/R 25168 Ig-134 58 rs938587020 0.4366 -0.413 0.001 N 0.393 0.384 0.26547132957 gnomAD-2.1.1 9.29E-05 None None None None N None 9.50649E-04 8.49E-05 None 0 0 None 0 None 0 0 0
S/R 25168 Ig-134 58 rs938587020 0.4366 -0.413 0.001 N 0.393 0.384 0.26547132957 gnomAD-3.1.2 2.95932E-04 None None None None N None 1.01415E-03 1.9667E-04 0 0 0 None 0 0 0 0 0
S/R 25168 Ig-134 58 rs938587020 0.4366 -0.413 0.001 N 0.393 0.384 0.26547132957 1000 genomes 5.99042E-04 None None None None N None 2.3E-03 0 None None 0 0 None None None 0 None
S/R 25168 Ig-134 58 rs938587020 0.4366 -0.413 0.001 N 0.393 0.384 0.26547132957 gnomAD-4.0.0 4.77572E-06 None None None None N None 0 0 None 0 0 None 5.64823E-05 0 0 0 0
S/P 25565 Ig-135 52 rs753679035 0.9806 0.262 0.999 D 0.697 0.62 0.552367828057 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
S/P 25565 Ig-135 52 rs753679035 0.9806 0.262 0.999 D 0.697 0.62 0.552367828057 gnomAD-4.0.0 8.21342E-06 None None None None N None 0 0 None 0 0 None 0 0 1.0796E-05 0 0
T/I 25854 Ig-136 57 rs886055245 0.064 -0.126 None N 0.342 0.17 0.277730125212 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/I 25854 Ig-136 57 rs886055245 0.064 -0.126 None N 0.342 0.17 0.277730125212 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 25854 Ig-136 57 rs886055245 0.064 -0.126 None N 0.342 0.17 0.277730125212 gnomAD-4.0.0 2.56333E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78822E-06 0 0
T/I 27333 Ig-140 56 rs1277663410 0.1003 0.315 0.001 N 0.382 0.179 0.312001716656 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
T/I 27333 Ig-140 56 rs1277663410 0.1003 0.315 0.001 N 0.382 0.179 0.312001716656 gnomAD-4.0.0 1.59131E-06 None None None None N None 0 0 None 0 2.77285E-05 None 0 0 0 0 0
M/I 27730 Ig-141 55 rs1229835465 0.6694 -0.533 0.521 N 0.393 0.279 0.579627256647 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
M/I 27730 Ig-141 55 rs1229835465 0.6694 -0.533 0.521 N 0.393 0.279 0.579627256647 gnomAD-4.0.0 6.8427E-07 None None None None I None 2.98864E-05 0 None 0 0 None 0 0 0 0 0
M/T 27730 Ig-141 55 None 0.2748 None 0.815 N 0.472 0.336 0.663846892577 gnomAD-4.0.0 1.59161E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85865E-06 0 0
S/L 28019 Ig-142 57 rs769665204 0.1031 -0.246 None N 0.259 0.119 0.525049811399 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.98E-06 0
L/S 28414 Ig-143 57 rs775228620 0.1029 -2.587 None N 0.38 0.131 0.289474373501 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
L/S 28414 Ig-143 57 rs775228620 0.1029 -2.587 None N 0.38 0.131 0.289474373501 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/S 28414 Ig-143 57 rs775228620 0.1029 -2.587 None N 0.38 0.131 0.289474373501 gnomAD-4.0.0 6.57108E-06 None None None None I None 0 0 None 0 0 None 0 0 1.4699E-05 0 0
L/W 28414 Ig-143 57 None 0.2129 None 0.828 N 0.593 0.225 0.591025817267 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/T 28809 Ig-144 55 rs1702904098 0.0748 None None N 0.209 0.118 0.216624796971 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 30188 Ig-148 57 rs1456715081 0.1559 None 0.004 N 0.365 0.201 0.349647731962 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 30188 Ig-148 57 rs1456715081 0.1559 None 0.004 N 0.365 0.201 0.349647731962 gnomAD-4.0.0 2.49705E-06 None None None None N None 0 0 None 0 2.23464E-05 None 0 0 1.70194E-06 1.13327E-05 0
S/N 30583 Ig-149 52 rs1698731118 0.2635 None 0.722 D 0.68 0.226 0.224531998449 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/N 30583 Ig-149 52 rs1698731118 0.2635 None 0.722 D 0.68 0.226 0.224531998449 gnomAD-4.0.0 6.5735E-06 None None None None N None 2.41406E-05 0 None 0 0 None 0 0 0 0 0
S/T 30583 Ig-149 52 None 0.0893 None 0.003 N 0.271 0.106 0.134241683229 gnomAD-4.0.0 1.59129E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85837E-06 0 0
T/N 30980 Ig-150 54 None 0.2712 None 0.994 N 0.564 0.432 0.531922418639 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 31272 Ig-151 55 rs758010794 0.1245 0.074 1.0 N 0.807 0.462 0.586756053714 gnomAD-2.1.1 3.62E-05 None None None None N None 0 0 None 0 4.46528E-04 None 0 None 0 8.9E-06 0
T/I 31272 Ig-151 55 rs758010794 0.1245 0.074 1.0 N 0.807 0.462 0.586756053714 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 3.85356E-04 None 0 0 0 0 0
T/I 31272 Ig-151 55 rs758010794 0.1245 0.074 1.0 N 0.807 0.462 0.586756053714 gnomAD-4.0.0 2.60262E-05 None None None None N None 0 0 None 0 9.13955E-04 None 0 0 8.4757E-07 0 0
T/I 31672 Ig-152 52 rs765777016 0.161 0.174 0.002 N 0.245 0.268 0.36256342048 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
T/I 31672 Ig-152 52 rs765777016 0.161 0.174 0.002 N 0.245 0.268 0.36256342048 gnomAD-4.0.0 6.842E-07 None None None None N None 0 0 None 0 2.51927E-05 None 0 0 0 0 0
T/S 31672 Ig-152 52 None 0.1329 None 0.6 N 0.377 0.246 0.192905019026 gnomAD-4.0.0 6.842E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99475E-07 0 0
L/F 32069 Ig-153 53 rs1285541377 0.2566 None 0.996 N 0.569 0.259 0.586419759405 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/F 32069 Ig-153 53 rs1285541377 0.2566 None 0.996 N 0.569 0.259 0.586419759405 gnomAD-4.0.0 1.8592E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54298E-06 0 0
E/K 32759 Ig-155 52 rs748573833 0.8037 -0.761 0.999 N 0.581 0.374 0.362960570912 gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 1.11408E-04 None 0 None 0 0 0
E/K 32759 Ig-155 52 rs748573833 0.8037 -0.761 0.999 N 0.581 0.374 0.362960570912 gnomAD-4.0.0 3.18233E-06 None None None None I None 0 0 None 0 5.54539E-05 None 0 0 0 0 0
H/P 33253 Ig-157 51 None 0.9699 None 1.0 N 0.776 0.589 0.620047664876 gnomAD-4.0.0 1.36901E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79945E-06 0 0
H/R 33253 Ig-157 51 None 0.8525 None 1.0 N 0.722 0.491 0.455722563999 gnomAD-4.0.0 1.36899E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79943E-06 0 0
Q/E 33554 Ig-158 59 None 0.6885 None 0.999 N 0.439 0.382 0.348324211639 gnomAD-4.0.0 1.59882E-06 None None None None N None 0 0 None 0 0 None 1.88637E-05 0 0 0 0
I/F 34193 Ig-160 57 None 0.1484 None 0.065 N 0.47 0.162 0.582419091513 gnomAD-4.0.0 1.59098E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85767E-06 0 0
Q/R 34317 Ig-161 60 rs745933614 0.3587 -0.423 0.026 N 0.467 0.29 0.194818534648 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 2.78552E-04 None 0 None 0 0 0
Q/R 34317 Ig-161 60 rs745933614 0.3587 -0.423 0.026 N 0.467 0.29 0.194818534648 gnomAD-4.0.0 6.84159E-06 None None None None N None 0 0 None 0 2.26723E-04 None 0 0 0 0 1.6564E-05
A/V 34420 Ig-162 58 None 0.4458 None 0.122 N 0.315 0.295 0.511848488485 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 34998 Ig-163 57 None 0.2697 None 0.835 N 0.433 0.262 0.369867359543 gnomAD-4.0.0 1.59091E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85755E-06 0 0
T/I 34998 Ig-163 57 rs397517794 0.4265 None 0.994 N 0.614 0.564 0.579924211245 gnomAD-4.0.0 3.1818E-06 None None None None N None 5.65227E-05 0 None 0 0 None 0 0 0 0 3.02334E-05
T/N 34998 Ig-163 57 rs397517794 0.4717 None 0.961 N 0.551 0.412 0.491317756052 gnomAD-4.0.0 1.5909E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85755E-06 0 0
T/A 35185 Ig-164 57 rs1688904998 0.1534 None 0.877 N 0.483 0.307 0.355450299083 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07383E-04 0
T/A 35185 Ig-164 57 rs1688904998 0.1534 None 0.877 N 0.483 0.307 0.355450299083 gnomAD-4.0.0 3.84275E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.02037E-05 0
T/I 35185 Ig-164 57 rs781567438 0.2237 -0.159 0.996 N 0.713 0.459 0.483224754729 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.85E-06 0
T/I 35185 Ig-164 57 rs781567438 0.2237 -0.159 0.996 N 0.713 0.459 0.483224754729 gnomAD-4.0.0 1.36828E-06 None None None None N None 0 2.23604E-05 None 0 0 None 0 0 8.99391E-07 0 0
T/N 35185 Ig-164 57 None 0.2958 None 0.992 N 0.636 0.362 0.443695250439 gnomAD-4.0.0 6.84138E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
E/K 35343 Ig-165 58 rs774519928 0.3588 -1.431 0.92 N 0.551 0.282 0.277317399466 gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
E/K 35343 Ig-165 58 rs774519928 0.3588 -1.431 0.92 N 0.551 0.282 0.277317399466 gnomAD-4.0.0 4.77262E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57241E-06 0 0
F/L 35476 Ig-166 57 None 0.1447 None None N 0.166 0.134 0.287603790349 gnomAD-4.0.0 1.59697E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86261E-06 0 0
T/I 35661 Ig-167 55 rs747649004 0.2678 0.175 0.967 N 0.659 0.501 0.510172456258 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 9.34E-05 0 0
T/I 35661 Ig-167 55 rs747649004 0.2678 0.175 0.967 N 0.659 0.501 0.510172456258 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.43E-05 0 0 0 0
T/I 35661 Ig-167 55 rs747649004 0.2678 0.175 0.967 N 0.659 0.501 0.510172456258 gnomAD-4.0.0 6.57462E-06 None None None None N None 0 0 None 0 0 None 9.43396E-05 0 0 0 0
S/C 35758 Ig-168 57 rs1318791339 0.1524 -0.435 0.78 N 0.617 0.403 0.567569374525 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/C 35758 Ig-168 57 rs1318791339 0.1524 -0.435 0.78 N 0.617 0.403 0.567569374525 gnomAD-4.0.0 6.36402E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.73099E-05 0
S/F 35758 Ig-168 57 None 0.227 None 0.484 N 0.663 0.345 0.703042832254 gnomAD-4.0.0 1.591E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8577E-06 0 0
T/I 35955 Ig-169 59 rs370267738 0.7222 None 1.0 N 0.721 0.472 0.619797697146 gnomAD-4.0.0 6.84145E-07 None None None -1.454(OBSL1) -0.348(OBSCN) N None 0 0 None 0 0 None 0 0 8.99404E-07 0 0
T/N 35955 Ig-169 59 rs370267738 0.668 -1.535 0.884 N 0.391 0.349 None gnomAD-2.1.1 1.2E-05 None None None -1.246(OBSL1) -0.793(OBSCN) N None 0 0 None 0 0 None 0 None 0 2.65E-05 0
T/N 35955 Ig-169 59 rs370267738 0.668 -1.535 0.884 N 0.391 0.349 None gnomAD-3.1.2 1.31E-05 None None None -1.246(OBSL1) -0.793(OBSCN) N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
T/N 35955 Ig-169 59 rs370267738 0.668 -1.535 0.884 N 0.391 0.349 None gnomAD-4.0.0 7.43567E-06 None None None -1.246(OBSL1) -0.793(OBSCN) N None 0 1.66678E-05 None 0 0 None 0 0 9.32295E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.