Structural position:

  • Domain Type: Ig
  • Aligned Position: 139
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand E

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
T/M 66 Ig-1 61 rs372755739 0.0744 -0.086 0.014 D 0.383 0.124 None gnomAD-2.1.1 4.24E-05 None None None 0.005(TCAP) N None 0 0 None 9.65E-05 0 None 9.8E-05 None 1.19408E-04 3.87E-05 0
T/M 66 Ig-1 61 rs372755739 0.0744 -0.086 0.014 D 0.383 0.124 None gnomAD-3.1.2 3.94E-05 None None None 0.005(TCAP) N None 0 0 0 0 0 None 9.42E-05 0 7.35E-05 0 0
T/M 66 Ig-1 61 rs372755739 0.0744 -0.086 0.014 D 0.383 0.124 None gnomAD-4.0.0 4.58489E-05 None None None 0.005(TCAP) N None 0 0 None 3.37769E-05 0 None 1.09327E-04 0 4.74569E-05 9.88056E-05 1.60041E-05
L/Q 162 Ig-2 59 rs145438758 0.419 -1.629 0.927 N 0.713 0.56 None gnomAD-2.1.1 3.54E-05 None None None -0.484(TCAP) N None 2.80359E-04 8.47E-05 None 0 0 None 0 None 0 0 0
L/Q 162 Ig-2 59 rs145438758 0.419 -1.629 0.927 N 0.713 0.56 None gnomAD-3.1.2 3.94E-05 None None None -0.484(TCAP) N None 1.20616E-04 6.55E-05 0 0 0 None 0 0 0 0 0
L/Q 162 Ig-2 59 rs145438758 0.419 -1.629 0.927 N 0.713 0.56 None 1000 genomes 1.99681E-04 None None None -0.484(TCAP) N None 0 1.4E-03 None None 0 0 None None None 0 None
L/Q 162 Ig-2 59 rs145438758 0.419 -1.629 0.927 N 0.713 0.56 None gnomAD-4.0.0 9.29267E-06 None None None -0.484(TCAP) N None 1.33234E-04 6.66511E-05 None 0 0 None 0 0 0 0 1.59995E-05
L/R 162 Ig-2 59 rs145438758 0.5589 -0.823 0.799 N 0.703 0.565 None gnomAD-2.1.1 6.37E-05 None None None -0.804(TCAP) N None 2.29568E-04 0 None 0 0 None 0 None 0 0 0
L/R 162 Ig-2 59 rs145438758 0.5589 -0.823 0.799 N 0.703 0.565 None gnomAD-3.1.2 2.63E-05 None None None -0.804(TCAP) N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
L/R 162 Ig-2 59 rs145438758 0.5589 -0.823 0.799 N 0.703 0.565 None gnomAD-4.0.0 2.62826E-05 None None None -0.804(TCAP) N None 9.64925E-05 0 None 0 0 None 0 0 0 0 0
L/V 162 Ig-2 59 rs762430512 0.157 -1.479 None N 0.347 0.068 0.427713192076 gnomAD-2.1.1 3.98E-06 None None None -0.105(TCAP) N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
L/V 162 Ig-2 59 rs762430512 0.157 -1.479 None N 0.347 0.068 0.427713192076 gnomAD-4.0.0 1.59044E-06 None None None -0.105(TCAP) N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
M/I 1001 Ig-3 59 rs794729522 0.5021 None None N 0.168 0.143 0.292787519742 gnomAD-4.0.0 6.36231E-06 None None None None N None 0 0 None 9.53107E-05 5.54785E-05 None 0 0 0 0 0
M/R 1001 Ig-3 59 rs148269839 0.3789 -0.568 0.065 N 0.523 0.378 None gnomAD-2.1.1 1.13354E-04 None None None None N None 0 0 None 0 0 None 0 None 3.98E-05 2.25334E-04 2.77393E-04
M/R 1001 Ig-3 59 rs148269839 0.3789 -0.568 0.065 N 0.523 0.378 None gnomAD-3.1.2 1.18247E-04 None None None None N None 0 0 0 0 0 None 0 0 2.64535E-04 0 0
M/R 1001 Ig-3 59 rs148269839 0.3789 -0.568 0.065 N 0.523 0.378 None gnomAD-4.0.0 1.44358E-04 None None None None N None 0 1.66644E-05 None 0 0 None 0 0 1.93218E-04 0 6.40184E-05
M/T 1001 Ig-3 59 rs148269839 0.3053 -1.37 None N 0.219 0.348 0.677378689129 gnomAD-2.1.1 8.86E-05 None None None None N None 0 1.69338E-04 None 0 0 None 0 None 6.76698E-04 7.77E-06 1.38696E-04
M/T 1001 Ig-3 59 rs148269839 0.3053 -1.37 None N 0.219 0.348 0.677378689129 gnomAD-3.1.2 5.91E-05 None None None None N None 0 1.30839E-04 0 0 0 None 4.70544E-04 0 1.47E-05 0 4.78011E-04
M/T 1001 Ig-3 59 rs148269839 0.3053 -1.37 None N 0.219 0.348 0.677378689129 gnomAD-4.0.0 3.71737E-05 None None None None N None 0 1.4998E-04 None 0 0 None 6.40205E-04 0 7.62702E-06 0 1.60046E-05
M/V 1001 Ig-3 59 None 0.1274 None None N 0.162 0.103 0.148003135375 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
V/L 1142 Ig-4 61 None 0.2122 None 0.625 N 0.527 0.34 0.598413393357 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/C 1350 Ig-5 60 rs550101167 0.3178 -0.87 1.0 D 0.758 0.696 None gnomAD-2.1.1 2E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 3.54E-05 0
R/C 1350 Ig-5 60 rs550101167 0.3178 -0.87 1.0 D 0.758 0.696 None gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 2.07469E-04 0
R/C 1350 Ig-5 60 rs550101167 0.3178 -0.87 1.0 D 0.758 0.696 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
R/C 1350 Ig-5 60 rs550101167 0.3178 -0.87 1.0 D 0.758 0.696 None gnomAD-4.0.0 9.29395E-06 None None None None N None 1.33323E-05 1.66644E-05 None 0 0 None 0 0 8.47502E-06 1.09808E-05 3.19959E-05
R/H 1350 Ig-5 60 rs539470256 0.1292 -1.385 1.0 N 0.759 0.549 None gnomAD-2.1.1 1.20597E-04 None None None None N None 0 2.2604E-04 None 0 1.50905E-04 None 5.8812E-04 None 7.97E-05 2.34E-05 0
R/H 1350 Ig-5 60 rs539470256 0.1292 -1.385 1.0 N 0.759 0.549 None gnomAD-3.1.2 7.89E-05 None None None None N None 0 6.55E-05 0 0 1.92382E-04 None 0 0 1.02899E-04 6.21375E-04 0
R/H 1350 Ig-5 60 rs539470256 0.1292 -1.385 1.0 N 0.759 0.549 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
R/H 1350 Ig-5 60 rs539470256 0.1292 -1.385 1.0 N 0.759 0.549 None gnomAD-4.0.0 6.56751E-05 None None None None N None 0 1.33324E-04 None 0 8.91902E-05 None 4.68691E-05 1.64962E-04 3.30521E-05 4.94093E-04 9.59908E-05
I/F 1516 Ig-6 60 None 0.757 None 0.468 D 0.595 0.347 0.679497533952 gnomAD-4.0.0 6.84197E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99358E-07 0 0
I/T 1516 Ig-6 60 rs1464496143 0.9588 -2.177 0.638 N 0.623 0.396 0.741560904565 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.83E-06 0
I/T 1516 Ig-6 60 rs1464496143 0.9588 -2.177 0.638 N 0.623 0.396 0.741560904565 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 1516 Ig-6 60 rs1464496143 0.9588 -2.177 0.638 N 0.623 0.396 0.741560904565 gnomAD-4.0.0 1.48716E-05 None None None None I None 0 0 None 0 0 None 0 0 2.03398E-05 0 0
I/V 1516 Ig-6 60 rs1184288875 0.4249 -1.324 0.043 N 0.399 0.116 None gnomAD-2.1.1 1.77E-05 None None None None I None 0 0 None 0 0 None 0 None 0 3.89E-05 0
I/V 1516 Ig-6 60 rs1184288875 0.4249 -1.324 0.043 N 0.399 0.116 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
I/V 1516 Ig-6 60 rs1184288875 0.4249 -1.324 0.043 N 0.399 0.116 None gnomAD-4.0.0 4.46156E-05 None None None None I None 1.33476E-05 0 None 0 0 None 0 0 6.01726E-05 0 0
D/E 1763 Ig-8 61 rs1325498080 0.597 -0.526 1.0 N 0.506 0.31 0.243398259712 gnomAD-2.1.1 7.98E-06 None None None None N None 0 5.79E-05 None 0 0 None 0 None 0 0 0
D/E 1763 Ig-8 61 rs1325498080 0.597 -0.526 1.0 N 0.506 0.31 0.243398259712 gnomAD-4.0.0 6.36653E-06 None None None None N None 0 9.14746E-05 None 0 0 None 0 0 0 0 0
V/I 2137 Ig-10 60 rs938420145 0.1063 None 0.997 N 0.503 0.326 0.723809522663 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.30959E-04 0 0 0 None 0 0 0 0 0
V/I 2137 Ig-10 60 rs938420145 0.1063 None 0.997 N 0.503 0.326 0.723809522663 gnomAD-4.0.0 6.56797E-06 None None None None N None 0 6.53937E-05 None 0 0 None 0 0 0 0 0
S/F 2232 Ig-11 59 rs377098846 0.8507 -0.831 1.0 N 0.763 0.643 None gnomAD-2.1.1 3.98E-06 None None None None N None 6.15E-05 0 None 0 0 None 0 None 0 0 0
T/M 2324 Ig-12 58 rs760633130 0.076 -0.223 0.996 D 0.679 0.52 None gnomAD-2.1.1 7.08E-05 None None None None N None 8.01E-05 0 None 0 2.00702E-04 None 3.26627E-04 None 3.98E-05 2.33E-05 0
T/M 2324 Ig-12 58 rs760633130 0.076 -0.223 0.996 D 0.679 0.52 None gnomAD-3.1.2 5.92E-05 None None None None N None 2.42E-05 0 0 0 9.60799E-04 None 0 3.18471E-03 1.47E-05 2.07641E-04 0
T/M 2324 Ig-12 58 rs760633130 0.076 -0.223 0.996 D 0.679 0.52 None gnomAD-4.0.0 4.08917E-05 None None None None N None 5.33333E-05 0 None 0 2.45098E-04 None 1.56221E-05 1.65017E-04 1.10172E-05 3.953E-04 0
T/P 2324 Ig-12 58 None 0.8209 None 0.988 D 0.671 0.595 0.534668972696 gnomAD-4.0.0 1.59057E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02133E-05
L/F 2413 Ig-13 58 rs780754758 0.7228 -1.723 1.0 D 0.671 0.292 0.734323642297 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
L/F 2413 Ig-13 58 rs780754758 0.7228 -1.723 1.0 D 0.671 0.292 0.734323642297 gnomAD-4.0.0 1.36815E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 1.65585E-05
V/A 2503 Ig-14 59 rs751964863 0.4151 -2.174 0.999 D 0.521 0.419 0.707016183132 gnomAD-2.1.1 2.83E-05 None None None None N None 0 0 None 0 4.0205E-04 None 0 None 0 0 0
V/A 2503 Ig-14 59 rs751964863 0.4151 -2.174 0.999 D 0.521 0.419 0.707016183132 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.9253E-04 None 0 0 0 0 0
V/A 2503 Ig-14 59 rs751964863 0.4151 -2.174 0.999 D 0.521 0.419 0.707016183132 gnomAD-4.0.0 5.57653E-06 None None None None N None 0 0 None 0 1.78293E-04 None 0 0 0 0 1.60041E-05
V/D 2503 Ig-14 59 None 0.9015 None 1.0 D 0.807 0.727 0.883884871053 gnomAD-4.0.0 6.841E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99319E-07 0 0
V/L 2503 Ig-14 59 rs1002285486 0.2845 -0.681 0.997 N 0.515 0.298 0.600613607152 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 5.45E-05 None 0 None 0 0 0
V/L 2503 Ig-14 59 rs1002285486 0.2845 -0.681 0.997 N 0.515 0.298 0.600613607152 gnomAD-4.0.0 1.59067E-06 None None None None N None 0 0 None 0 2.77439E-05 None 0 0 0 0 0
T/I 2590 Ig-15 58 rs761445567 0.2097 -0.11 0.998 N 0.703 0.506 0.534287799004 gnomAD-2.1.1 1.42E-05 None None None None N None 4.04E-05 0 None 0 0 None 0 None 0 2.34E-05 0
T/I 2590 Ig-15 58 rs761445567 0.2097 -0.11 0.998 N 0.703 0.506 0.534287799004 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
T/I 2590 Ig-15 58 rs761445567 0.2097 -0.11 0.998 N 0.703 0.506 0.534287799004 gnomAD-4.0.0 6.1976E-06 None None None None N None 1.33586E-05 0 None 0 0 None 0 0 6.78057E-06 0 1.60067E-05
I/N 2677 Ig-16 57 rs2091449758 0.1512 None None N 0.47 0.231 0.689912882814 gnomAD-4.0.0 1.36816E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7986E-06 0 0
I/T 2677 Ig-16 57 rs2091449758 0.1584 None 0.001 N 0.295 0.226 0.595302103986 gnomAD-4.0.0 2.05225E-06 None None None None N None 0 0 None 0 7.56201E-05 None 0 0 0 0 0
R/K 2765 Ig-17 59 None 0.0724 None None N 0.238 0.054 0.168933306366 gnomAD-4.0.0 1.59051E-06 None None None None N None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
R/M 2765 Ig-17 59 None 0.137 None 0.484 N 0.559 0.301 0.388653054685 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92382E-04 None 0 0 0 0 0
R/M 2765 Ig-17 59 None 0.137 None 0.484 N 0.559 0.301 0.388653054685 gnomAD-4.0.0 6.57073E-06 None None None None N None 0 0 None 0 1.92382E-04 None 0 0 0 0 0
R/T 2765 Ig-17 59 None 0.0914 None None N 0.361 0.256 0.351614576976 gnomAD-4.0.0 1.59051E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85651E-06 0 0
M/I 2852 Ig-18 58 rs1464875201 0.2881 -0.979 0.001 N 0.191 0.277 0.372446077551 gnomAD-2.1.1 7.96E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.8E-06 0
M/I 2852 Ig-18 58 rs1464875201 0.2881 -0.979 0.001 N 0.191 0.277 0.372446077551 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07383E-04 0
M/I 2852 Ig-18 58 rs1464875201 0.2881 -0.979 0.001 N 0.191 0.277 0.372446077551 gnomAD-4.0.0 2.56108E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.68025E-05 0
M/K 2852 Ig-18 58 None 0.4136 None 0.351 N 0.454 0.411 0.583209036909 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.21507E-04 0
M/V 2852 Ig-18 58 rs1382675661 0.103 -1.454 0.001 N 0.204 0.341 0.276898752692 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
M/V 2852 Ig-18 58 rs1382675661 0.103 -1.454 0.001 N 0.204 0.341 0.276898752692 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/V 2852 Ig-18 58 rs1382675661 0.103 -1.454 0.001 N 0.204 0.341 0.276898752692 gnomAD-4.0.0 2.0298E-06 None None None None N None 0 0 None 0 0 None 0 0 2.40978E-06 0 0
I/T 2939 Ig-19 58 None 0.4464 None 0.285 N 0.523 0.249 0.560681312399 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
N/I 3026 Ig-20 58 rs11900987 0.171 0.338 0.642 N 0.571 0.251 None gnomAD-2.1.1 5.87166E-04 None None None None N None 6.36713E-03 5.65E-05 None 0 0 None 3.27E-05 None 0 3.1E-05 0
N/I 3026 Ig-20 58 rs11900987 0.171 0.338 0.642 N 0.571 0.251 None gnomAD-3.1.2 1.82638E-03 None None None None N None 6.41737E-03 3.27097E-04 0 0 0 None 0 0 2.94E-05 0 2.39006E-03
N/I 3026 Ig-20 58 rs11900987 0.171 0.338 0.642 N 0.571 0.251 None 1000 genomes 1.59744E-03 None None None None N None 6.1E-03 0 None None 0 0 None None None 0 None
N/I 3026 Ig-20 58 rs11900987 0.171 0.338 0.642 N 0.571 0.251 None gnomAD-4.0.0 4.50396E-04 None None None None N None 7.95449E-03 1.83266E-04 None 0 0 None 0 9.89772E-04 2.37288E-05 5.48992E-05 1.27988E-03
L/R 3115 Ig-21 58 rs773714030 0.5312 -1.688 0.484 N 0.576 0.461 0.731167935182 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.81E-06 0
F/L 3206 Ig-22 60 rs1385591866 0.7523 -1.311 0.028 N 0.422 0.311 0.309839678437 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
F/L 3206 Ig-22 60 rs1385591866 0.7523 -1.311 0.028 N 0.422 0.311 0.309839678437 gnomAD-4.0.0 3.18109E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86541E-05 0
E/K 3402 Ig-24 58 rs766262957 0.447 -1.001 0.999 N 0.571 0.566 0.492611691308 gnomAD-2.1.1 2.48E-05 None None None None N None 4.01E-05 0 None 0 0 None 3.27E-05 None 0 3.11E-05 1.38889E-04
E/K 3402 Ig-24 58 rs766262957 0.447 -1.001 0.999 N 0.571 0.566 0.492611691308 gnomAD-3.1.2 4.6E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 4.41E-05 0 0
E/K 3402 Ig-24 58 rs766262957 0.447 -1.001 0.999 N 0.571 0.566 0.492611691308 gnomAD-4.0.0 1.85887E-05 None None None None N None 5.34017E-05 0 None 0 0 None 0 0 2.11874E-05 1.09801E-05 0
T/A 3718 Ig-26 59 rs747357550 0.1114 -1.526 None None None 0.122 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
T/A 3718 Ig-26 59 rs747357550 0.1114 -1.526 None None None 0.122 None gnomAD-4.0.0 1.59118E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85817E-06 0 0
I/N 3878 Ig-27 59 None 0.6751 None 0.996 N 0.663 0.403 None gnomAD-4.0.0 6.84195E-07 None None None None N None 0 0 None 0 0 None 0 1.7337E-04 0 0 0
I/T 3878 Ig-27 59 None 0.6015 None 0.92 N 0.539 0.257 None gnomAD-4.0.0 1.36839E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79889E-06 0 0
E/K 4758 Ig-30 59 rs928709551 0.7152 -0.597 0.698 N 0.511 0.321 0.327952845175 gnomAD-2.1.1 3.18E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
E/K 4758 Ig-30 59 rs928709551 0.7152 -0.597 0.698 N 0.511 0.321 0.327952845175 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/K 4758 Ig-30 59 rs928709551 0.7152 -0.597 0.698 N 0.511 0.321 0.327952845175 gnomAD-4.0.0 6.57203E-06 None None None None N None 2.41324E-05 0 None 0 0 None 0 0 0 0 0
E/A 4853 Ig-31 59 rs1264041107 0.2684 -1.189 0.4 N 0.469 0.212 0.323886383625 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/A 4853 Ig-31 59 rs1264041107 0.2684 -1.189 0.4 N 0.469 0.212 0.323886383625 gnomAD-4.0.0 6.57099E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46998E-05 0 0
E/Q 4853 Ig-31 59 None 0.1564 None 0.997 N 0.585 0.27 0.356690202451 gnomAD-4.0.0 1.59118E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
E/D 4946 Ig-32 59 rs1169291552 0.1854 None 0.054 D 0.233 0.231 0.328486982098 gnomAD-4.0.0 4.77567E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57638E-06 0 0
E/K 4946 Ig-32 59 rs2081307227 0.2499 None 0.978 N 0.503 0.377 0.366277470483 gnomAD-4.0.0 2.053E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99525E-07 0 3.31455E-05
D/G 5040 Ig-33 60 rs1315700657 0.4449 None 0.811 N 0.573 0.33 0.32714864917 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
D/H 5040 Ig-33 60 None 0.3755 None 0.984 N 0.657 0.341 0.3085936734 gnomAD-4.0.0 1.36843E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79896E-06 0 0
D/Y 5040 Ig-33 60 None 0.3189 None 0.995 N 0.722 0.414 0.604632981478 gnomAD-4.0.0 1.36843E-06 None None None None N None 0 0 None 0 5.03981E-05 None 0 0 0 0 0
I/L 5226 Ig-35 59 None 0.0735 None None N 0.191 0.107 0.519296960841 gnomAD-4.0.0 4.77345E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.29824E-05 0
I/M 5226 Ig-35 59 None 0.0634 None 0.108 N 0.445 0.059 0.370051654043 gnomAD-4.0.0 1.59116E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
K/E 5319 Ig-36 59 None 0.6388 None 0.767 N 0.361 0.212 0.292423486923 gnomAD-4.0.0 1.59131E-06 None None None None N None 0 0 None 0 2.77423E-05 None 0 0 0 0 0
K/R 5319 Ig-36 59 rs779733584 0.0998 None 0.996 N 0.435 0.316 0.461671691612 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/R 5319 Ig-36 59 rs779733584 0.0998 None 0.996 N 0.435 0.316 0.461671691612 gnomAD-4.0.0 1.85907E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54282E-06 0 0
K/T 5319 Ig-36 59 rs779733584 0.3776 -1.198 0.999 N 0.698 0.469 0.420939154896 gnomAD-2.1.1 1.21E-05 None None None None N None 0 8.7E-05 None 0 0 None 0 None 0 0 0
K/T 5319 Ig-36 59 rs779733584 0.3776 -1.198 0.999 N 0.698 0.469 0.420939154896 gnomAD-4.0.0 2.05266E-06 None None None None N None 0 6.70931E-05 None 0 0 None 0 0 0 0 0
E/A 5415 Ig-37 59 None 0.2721 None 0.334 N 0.509 0.263 0.285316908763 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 3.66327E-05
E/D 5415 Ig-37 59 None 0.1804 None 0.004 N 0.271 0.082 0.282575091529 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 3.66327E-05
E/K 5415 Ig-37 59 rs761181567 0.3611 -0.695 0.007 N 0.292 0.286 0.223847106136 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
E/G 5508 Ig-38 59 None 0.3662 None 0.999 N 0.721 0.538 0.60906947716 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
R/G 5602 Ig-39 60 None 0.1153 None 0.012 N 0.44 0.31 0.441221003447 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
Q/K 5695 Ig-40 59 None 0.1874 None 0.27 N 0.413 0.22 0.158396225186 gnomAD-4.0.0 1.59124E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85835E-06 0 0
Y/H 5788 Ig-41 59 rs1484048025 0.1218 -1.051 0.006 N 0.285 0.253 0.227260227426 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
Y/H 5788 Ig-41 59 rs1484048025 0.1218 -1.051 0.006 N 0.285 0.253 0.227260227426 gnomAD-4.0.0 1.59121E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
E/Q 6070 Ig-44 59 rs1238374094 0.2557 -0.931 1.0 N 0.577 0.293 0.327952845175 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
E/Q 6070 Ig-44 59 rs1238374094 0.2557 -0.931 1.0 N 0.577 0.293 0.327952845175 gnomAD-4.0.0 1.59202E-06 None None None None N None 0 0 None 0 2.77886E-05 None 0 0 0 0 0
H/R 6257 Ig-46 59 rs371299041 0.0714 -1.134 0.007 N 0.404 0.112 None gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 1.57E-05 0
H/R 6257 Ig-46 59 rs371299041 0.0714 -1.134 0.007 N 0.404 0.112 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
H/R 6257 Ig-46 59 rs371299041 0.0714 -1.134 0.007 N 0.404 0.112 None gnomAD-4.0.0 1.17755E-05 None None None None N None 0 0 None 0 0 None 0 1.64582E-04 1.27155E-05 3.29337E-05 0
H/Y 6257 Ig-46 59 None 0.0791 None 0.175 N 0.478 0.108 0.286465849087 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
Q/H 6350 Ig-47 59 rs113892821 0.1506 -1.139 0.786 N 0.448 0.173 0.176091768786 gnomAD-2.1.1 3.19E-05 None None None None N None 0 1.17924E-03 None 0 0 None 0 None 0 0 0
Q/H 6350 Ig-47 59 rs113892821 0.1506 -1.139 0.786 N 0.448 0.173 0.176091768786 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
Q/H 6350 Ig-47 59 rs113892821 0.1506 -1.139 0.786 N 0.448 0.173 0.176091768786 gnomAD-4.0.0 1.23992E-06 None None None None N None 0 1.66939E-05 None 0 0 None 0 0 0 1.09859E-05 0
R/S 6443 Ig-48 59 rs1217984218 0.5614 None 0.92 N 0.559 0.463 0.38342384377 gnomAD-4.0.0 6.84456E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99633E-07 0 0
E/D 6539 Ig-49 59 None 0.158 None None N 0.308 0.077 0.0716867268079 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 3.66327E-05
Q/R 6726 Ig-51 60 rs1159916010 0.1241 None 0.669 N 0.527 0.324 0.257292322809 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
Q/R 6726 Ig-51 60 rs1159916010 0.1241 None 0.669 N 0.527 0.324 0.257292322809 gnomAD-4.0.0 6.5735E-06 None None None None N None 2.41243E-05 0 None 0 0 None 0 0 0 0 0
Q/H 6913 Ig-53 60 None 0.1744 None 0.991 N 0.455 0.311 0.269111216191 gnomAD-4.0.0 1.59294E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86066E-06 0 0
Q/R 6913 Ig-53 60 rs1352796608 0.1043 None 0.719 N 0.389 0.13 0.218112801441 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/R 6913 Ig-53 60 rs1352796608 0.1043 None 0.719 N 0.389 0.13 0.218112801441 gnomAD-4.0.0 2.56397E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78927E-06 0 0
R/K 7006 Ig-54 59 rs771200026 0.0625 -1.139 None N 0.228 0.161 0.18995819373 gnomAD-2.1.1 8.04E-06 None None None None N None 1.29249E-04 0 None 0 0 None 0 None 0 0 0
R/K 7006 Ig-54 59 rs771200026 0.0625 -1.139 None N 0.228 0.161 0.18995819373 gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
R/K 7006 Ig-54 59 rs771200026 0.0625 -1.139 None N 0.228 0.161 0.18995819373 gnomAD-4.0.0 5.12608E-06 None None None None N None 6.7659E-05 0 None 0 0 None 0 0 0 0 0
Q/H 7102 Ig-55 59 None 0.1464 None 0.927 N 0.512 0.238 0.290590437066 gnomAD-4.0.0 1.59186E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02535E-05
E/G 7195 Ig-56 59 rs2078794868 0.514 None 0.993 D 0.703 0.454 0.582232187747 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.9305E-04 None 0 0 0 0 0
E/G 7195 Ig-56 59 rs2078794868 0.514 None 0.993 D 0.703 0.454 0.582232187747 gnomAD-4.0.0 6.57134E-06 None None None None N None 0 0 None 0 1.9305E-04 None 0 0 0 0 0
V/L 7381 Ig-58 59 rs762179106 0.1848 -0.122 0.057 N 0.333 0.145 0.488196290542 gnomAD-2.1.1 4.03E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
V/L 7381 Ig-58 59 rs762179106 0.1848 -0.122 0.057 N 0.333 0.145 0.488196290542 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/L 7381 Ig-58 59 rs762179106 0.1848 -0.122 0.057 N 0.333 0.145 0.488196290542 gnomAD-4.0.0 6.57549E-06 None None None None N None 2.41383E-05 0 None 0 0 None 0 0 0 0 0
K/T 7477 Ig-59 59 rs774575742 0.1158 -1.089 0.01 N 0.29 0.275 0.264081493735 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
R/S 7573 Ig-60 59 None 0.4496 None 0.514 N 0.496 0.367 0.319114376414 gnomAD-4.0.0 6.84324E-07 None None None None N None 0 0 None 0 0 None 1.87266E-05 0 0 0 0
T/M 7667 Ig-61 60 rs374430623 0.0802 -0.221 0.994 D 0.579 0.4 None gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
T/M 7667 Ig-61 60 rs374430623 0.0802 -0.221 0.994 D 0.579 0.4 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/M 7667 Ig-61 60 rs374430623 0.0802 -0.221 0.994 D 0.579 0.4 None gnomAD-4.0.0 2.23174E-05 None None None None N None 0 0 None 0 0 None 0 1.64636E-04 2.7982E-05 2.1966E-05 0
T/R 7667 Ig-61 60 rs374430623 0.0918 -0.574 0.973 N 0.553 0.353 0.659491765867 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 1.78E-05 0
T/R 7667 Ig-61 60 rs374430623 0.0918 -0.574 0.973 N 0.553 0.353 0.659491765867 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/R 7667 Ig-61 60 rs374430623 0.0918 -0.574 0.973 N 0.553 0.353 0.659491765867 gnomAD-4.0.0 4.3395E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69588E-06 4.39319E-05 1.60185E-05
H/P 7760 Ig-62 59 rs1577994546 0.9175 None 0.997 N 0.58 0.58 0.645372302287 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
H/P 7760 Ig-62 59 rs1577994546 0.9175 None 0.997 N 0.58 0.58 0.645372302287 gnomAD-4.0.0 6.57047E-06 None None None None N None 2.41161E-05 0 None 0 0 None 0 0 0 0 0
H/R 7760 Ig-62 59 rs1577994546 0.223 None 0.952 N 0.489 0.348 0.278143212241 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/Y 7760 Ig-62 59 rs759847053 0.1808 0.89 0.998 N 0.534 0.3 0.415564226483 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 0 0
H/Y 7760 Ig-62 59 rs759847053 0.1808 0.89 0.998 N 0.534 0.3 0.415564226483 gnomAD-4.0.0 4.78991E-06 None None None None N None 0 0 None 0 0 None 0 0 0 8.11632E-05 0
N/S 8043 Ig-65 59 rs1462695230 0.0689 -0.838 None N 0.244 0.093 0.0986583533028 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/S 8043 Ig-65 59 rs1462695230 0.0689 -0.838 None N 0.244 0.093 0.0986583533028 gnomAD-4.0.0 1.59126E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
E/G 8136 Ig-66 59 None 0.2976 None 0.722 D 0.594 0.488 0.561714622075 gnomAD-4.0.0 1.59127E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85834E-06 0 0
E/Q 8136 Ig-66 59 None 0.1039 None 0.075 N 0.41 0.182 0.272639205421 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
E/D 8229 Ig-67 59 rs761867872 0.6541 -1.062 0.99 N 0.579 0.325 0.394230963961 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
E/D 8229 Ig-67 59 rs761867872 0.6541 -1.062 0.99 N 0.579 0.325 0.394230963961 gnomAD-4.0.0 6.84215E-07 None None None None N None 2.98793E-05 0 None 0 0 None 0 0 0 0 0
E/K 8229 Ig-67 59 None 0.5684 None 0.4 N 0.335 0.277 0.300784259202 gnomAD-4.0.0 1.59132E-06 None None None None N None 0 0 None 0 0 None 1.88253E-05 0 0 0 0
V/A 8322 Ig-68 59 None 0.201 None 0.013 D 0.305 0.199 0.551879694509 gnomAD-4.0.0 4.77412E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57604E-06 0 0
V/I 8322 Ig-68 59 rs201571580 0.0721 -0.466 0.602 N 0.539 0.178 0.539612970712 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
V/I 8322 Ig-68 59 rs201571580 0.0721 -0.466 0.602 N 0.539 0.178 0.539612970712 gnomAD-4.0.0 6.84232E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99514E-07 0 0
V/L 8322 Ig-68 59 rs201571580 0.1489 -0.5 0.385 N 0.555 0.184 0.451118754121 gnomAD-2.1.1 5.88962E-04 None None None None N None 8.27E-05 5.66E-05 None 0 0 None 0 None 3.19744E-04 1.17191E-03 4.21467E-04
V/L 8322 Ig-68 59 rs201571580 0.1489 -0.5 0.385 N 0.555 0.184 0.451118754121 gnomAD-3.1.2 4.86349E-04 None None None None N None 1.20656E-04 1.30959E-04 0 0 0 None 7.53721E-04 0 8.52766E-04 0 4.77555E-04
V/L 8322 Ig-68 59 rs201571580 0.1489 -0.5 0.385 N 0.555 0.184 0.451118754121 gnomAD-4.0.0 6.38259E-04 None None None None N None 1.46631E-04 8.33167E-05 None 0 0 None 5.31184E-04 0 7.94258E-04 0 6.88154E-04
Q/H 8418 Ig-69 59 rs750071508 0.2418 -1.128 0.995 N 0.495 0.214 0.342400092842 gnomAD-2.1.1 1.79E-05 None None None None N None 4.14E-05 8.51E-05 None 0 0 None 0 None 0 7.85E-06 0
Q/H 8418 Ig-69 59 rs750071508 0.2418 -1.128 0.995 N 0.495 0.214 0.342400092842 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
Q/H 8418 Ig-69 59 rs750071508 0.2418 -1.128 0.995 N 0.495 0.214 0.342400092842 gnomAD-4.0.0 3.42222E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49816E-06 0 0
E/A 8608 Ig-71 60 None 0.3068 None 0.987 N 0.521 0.409 0.476051820916 gnomAD-4.0.0 6.84262E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99536E-07 0 0
E/G 8608 Ig-71 60 None 0.456 None 0.998 D 0.615 0.508 0.582764979894 gnomAD-4.0.0 6.84262E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99536E-07 0 0
Q/E 8795 Ig-73 60 None 0.0952 None 0.071 N 0.349 0.121 0.276482976112 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
Q/R 8795 Ig-73 60 None 0.0791 None 0.046 N 0.433 0.123 0.171388866994 gnomAD-4.0.0 1.59134E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85847E-06 0 0
K/R 8888 Ig-74 59 None 0.1043 None 0.959 N 0.525 0.196 0.407767136052 gnomAD-4.0.0 1.59166E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85878E-06 0 0
E/V 9077 Ig-76 59 rs1184239889 0.2819 -0.218 0.733 N 0.449 0.304 0.552408913969 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
V/A 9263 Ig-78 59 None 0.2021 None 0.826 D 0.463 0.259 0.63498429051 gnomAD-4.0.0 1.59131E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43295E-05 0
N/I 9359 Ig-79 59 None 0.2054 None 0.794 None 0.631 0.309 0.604580495079 gnomAD-4.0.0 6.84185E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9946E-07 0 0
N/S 9359 Ig-79 59 rs794727988 0.0975 None 0.183 None 0.518 0.131 0.159798565429 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
N/S 9359 Ig-79 59 rs794727988 0.0975 None 0.183 None 0.518 0.131 0.159798565429 gnomAD-4.0.0 1.23935E-06 None None None None N None 1.33497E-05 0 None 0 0 None 0 0 0 1.09796E-05 0
E/Q 9757 Ig-83 60 None 0.342 None 0.957 None 0.313 0.234 0.374970422459 gnomAD-4.0.0 1.59097E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85771E-06 0 0
R/T 9959 Ig-84 60 None 0.3531 None 0.001 None 0.307 0.335 0.24896430686 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 10046 Ig-85 58 rs768446273 0.1419 -0.809 0.019 None 0.451 0.186 0.231873229951 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.85E-06 0
T/I 10046 Ig-85 58 rs535268419 0.1496 0.24 None None 0.325 0.209 None gnomAD-2.1.1 2.81E-05 None None None None N None 0 0 None 0 0 None 2.28743E-04 None 0 0 0
T/I 10046 Ig-85 58 rs535268419 0.1496 0.24 None None 0.325 0.209 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06782E-04 0
T/I 10046 Ig-85 58 rs535268419 0.1496 0.24 None None 0.325 0.209 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
T/I 10046 Ig-85 58 rs535268419 0.1496 0.24 None None 0.325 0.209 None gnomAD-4.0.0 9.29383E-06 None None None None N None 0 0 None 0 0 None 0 1.64962E-04 0 1.42716E-04 1.60041E-05
T/I 10135 Ig-86 58 rs138493804 0.584 -0.56 0.134 None 0.467 0.247 None gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.85E-06 0
T/I 10135 Ig-86 58 rs138493804 0.584 -0.56 0.134 None 0.467 0.247 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 10135 Ig-86 58 rs138493804 0.584 -0.56 0.134 None 0.467 0.247 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
T/I 10135 Ig-86 58 rs138493804 0.584 -0.56 0.134 None 0.467 0.247 None gnomAD-4.0.0 1.30117E-05 None None None None N None 0 0 None 0 0 None 0 0 1.77987E-05 0 0
H/N 13744 Ig-87 61 None 0.546 None 0.01 N 0.267 0.164 0.263140351381 gnomAD-4.0.0 6.84368E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99637E-07 0 0
H/R 13744 Ig-87 61 None 0.746 None 0.642 N 0.475 0.281 0.270889551736 gnomAD-4.0.0 1.59196E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85954E-06 0 0
H/Y 13744 Ig-87 61 rs1178244629 0.3342 0.651 0.784 N 0.459 0.22 0.340273420219 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
H/Y 13744 Ig-87 61 rs1178244629 0.3342 0.651 0.784 N 0.459 0.22 0.340273420219 gnomAD-4.0.0 2.0531E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69891E-06 0 0
V/A 14110 Ig-91 57 rs34706299 0.8491 -2.453 0.994 D 0.455 0.411 None gnomAD-2.1.1 3.40026E-04 None None None None N None 0 5.67E-05 None 1.06527E-03 0 None 8.50118E-04 None 4E-05 4.07837E-04 4.22416E-04
V/A 14110 Ig-91 57 rs34706299 0.8491 -2.453 0.994 D 0.455 0.411 None gnomAD-3.1.2 3.02476E-04 None None None None N None 7.24E-05 0 0 5.77034E-04 0 None 0 0 4.70616E-04 1.86799E-03 0
V/A 14110 Ig-91 57 rs34706299 0.8491 -2.453 0.994 D 0.455 0.411 None 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 0 0 None None None 2E-03 None
V/A 14110 Ig-91 57 rs34706299 0.8491 -2.453 0.994 D 0.455 0.411 None gnomAD-4.0.0 2.67782E-04 None None None None N None 8.00064E-05 6.66889E-05 None 7.43695E-04 0 None 1.5623E-05 0 2.66217E-04 7.46908E-04 2.72253E-04
V/I 14110 Ig-91 57 rs1230881799 0.1087 None 0.543 N 0.209 0.2 0.580153967196 gnomAD-4.0.0 2.73773E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69902E-06 0 1.65761E-05
I/M 14376 Ig-94 58 rs1559959762 0.1614 None 0.087 N 0.507 0.057 0.28492961333 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/M 14376 Ig-94 58 rs1559959762 0.1614 None 0.087 N 0.507 0.057 0.28492961333 gnomAD-4.0.0 3.18555E-06 None None None None N None 0 4.57477E-05 None 0 0 None 0 0 0 0 0
I/V 14376 Ig-94 58 rs181000791 0.0763 -1.892 None N 0.2 0.05 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
I/V 14376 Ig-94 58 rs181000791 0.0763 -1.892 None N 0.2 0.05 None gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 14376 Ig-94 58 rs181000791 0.0763 -1.892 None N 0.2 0.05 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
I/V 14376 Ig-94 58 rs181000791 0.0763 -1.892 None N 0.2 0.05 None gnomAD-4.0.0 3.7194E-06 None None None None N None 1.33316E-05 0 None 0 0 None 0 0 4.23941E-06 0 0
V/M 14465 Ig-95 58 None 0.1432 None 0.942 D 0.683 0.163 0.412328234245 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/N 14643 Ig-97 58 None 0.3859 None 0.896 N 0.677 0.271 0.762871968251 gnomAD-4.0.0 2.05317E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69878E-06 0 0
T/I 14821 Ig-99 57 rs756640775 0.1262 0.027 0.026 N 0.351 0.199 0.347217280506 gnomAD-2.1.1 2.14E-05 None None None None N None 0 1.63036E-04 None 0 0 None 0 None 0 0 0
T/I 14821 Ig-99 57 rs756640775 0.1262 0.027 0.026 N 0.351 0.199 0.347217280506 gnomAD-4.0.0 4.15124E-06 None None None None N None 0 9.57763E-05 None 0 0 None 0 0 1.80923E-06 0 0
T/S 14821 Ig-99 57 None 0.2211 None 0.946 N 0.523 0.286 0.379707525713 gnomAD-4.0.0 3.45799E-06 None None None None N None 0 0 None 0 0 None 0 0 3.61749E-06 0 1.67364E-05
V/L 14910 Ig-100 58 None 0.1448 None None N 0.237 0.132 0.441949972293 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
V/I 14999 Ig-101 58 rs1382155901 0.0954 -0.494 0.37 N 0.235 0.108 0.516770950016 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.92E-05 None 0 0 None 0 None 0 0 0
V/I 14999 Ig-101 58 rs1382155901 0.0954 -0.494 0.37 N 0.235 0.108 0.516770950016 gnomAD-4.0.0 3.19049E-06 None None None None N None 0 4.59031E-05 None 0 0 None 0 0 0 0 0
V/L 15088 Ig-102 58 rs1281379374 0.1107 -0.701 None N 0.228 0.182 0.163833314356 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
V/L 15088 Ig-102 58 rs1281379374 0.1107 -0.701 None N 0.228 0.182 0.163833314356 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/L 15088 Ig-102 58 rs1281379374 0.1107 -0.701 None N 0.228 0.182 0.163833314356 gnomAD-4.0.0 6.58605E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4728E-05 0 0
V/L 15177 Ig-103 58 rs1298913743 0.2474 -0.711 0.835 N 0.496 0.227 0.53819168318 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 0 0
V/L 15177 Ig-103 58 rs1298913743 0.2474 -0.711 0.835 N 0.496 0.227 0.53819168318 gnomAD-4.0.0 1.59379E-06 None None None None N None 0 0 None 0 0 None 1.88402E-05 0 0 0 0
R/G 15265 Ig-104 58 rs764279926 0.7791 -1.732 0.822 D 0.611 0.529 0.693294191124 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/G 15265 Ig-104 58 rs764279926 0.7791 -1.732 0.822 D 0.611 0.529 0.693294191124 gnomAD-4.0.0 3.42291E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.63876E-05 1.65848E-05
T/N 15359 Ig-105 58 rs780024396 0.1342 -1.058 0.741 N 0.52 0.215 0.307016933798 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
T/N 15359 Ig-105 58 rs780024396 0.1342 -1.058 0.741 N 0.52 0.215 0.307016933798 gnomAD-4.0.0 3.18866E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72833E-06 0 0
I/L 15448 Ig-106 58 None 0.1563 None 0.91 N 0.467 0.194 0.596036732933 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/G 15623 Ig-108 56 None 0.2464 None 0.939 N 0.616 0.419 0.423119698836 gnomAD-4.0.0 1.5947E-06 None None None None N None 0 0 None 0 0 None 0 0 2.864E-06 0 0
R/C 17335 Ig-112 85 rs763755830 0.1302 -1.859 0.002 N 0.571 0.178 None gnomAD-2.1.1 1.46E-05 None None None None N None 0 0 None 0 5.23E-05 None 0 None 4.07E-05 1.59E-05 0
R/C 17335 Ig-112 85 rs763755830 0.1302 -1.859 0.002 N 0.571 0.178 None gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
R/C 17335 Ig-112 85 rs763755830 0.1302 -1.859 0.002 N 0.571 0.178 None gnomAD-4.0.0 1.30764E-05 None None None None N None 1.34351E-05 0 None 0 2.24558E-05 None 1.56902E-05 0 1.36057E-05 2.22489E-05 0
R/G 17335 Ig-112 85 None 0.3682 None None N 0.398 0.236 0.490771696789 gnomAD-4.0.0 6.87758E-07 None None None None N None 0 0 None 0 2.53846E-05 None 0 0 0 0 0
R/H 17335 Ig-112 85 rs367603302 0.0822 -2.017 0.006 N 0.339 0.129 None gnomAD-2.1.1 1.31519E-04 None None None None N None 4.98587E-04 1.15788E-04 None 1.11449E-03 0 None 3.42E-05 None 0 3.19E-05 5.74878E-04
R/H 17335 Ig-112 85 rs367603302 0.0822 -2.017 0.006 N 0.339 0.129 None gnomAD-3.1.2 1.71143E-04 None None None None N None 4.83045E-04 0 0 8.65052E-04 0 None 0 0 4.42E-05 0 0
R/H 17335 Ig-112 85 rs367603302 0.0822 -2.017 0.006 N 0.339 0.129 None gnomAD-4.0.0 8.65936E-05 None None None None N None 3.89607E-04 8.45881E-05 None 1.09837E-03 0 None 0 3.31126E-04 5.35884E-05 2.2303E-05 9.66526E-05
R/L 17335 Ig-112 85 rs367603302 0.1622 None None N 0.408 0.224 0.497613835824 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
R/L 17335 Ig-112 85 rs367603302 0.1622 None None N 0.408 0.224 0.497613835824 gnomAD-4.0.0 6.58241E-06 None None None None N None 2.41523E-05 0 None 0 0 None 0 0 0 0 0
I/T 17730 Ig-113 54 rs1337110210 0.1713 -2.721 None N 0.353 0.129 0.542587012665 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
I/T 17730 Ig-113 54 rs1337110210 0.1713 -2.721 None N 0.353 0.129 0.542587012665 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/T 17730 Ig-113 54 rs1337110210 0.1713 -2.721 None N 0.353 0.129 0.542587012665 gnomAD-4.0.0 6.58042E-06 None None None None N None 2.41313E-05 0 None 0 0 None 0 0 0 0 0
I/V 17730 Ig-113 54 None 0.0996 None None N 0.162 0.081 0.367612772649 gnomAD-4.0.0 3.18454E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72141E-06 0 0
S/C 18031 Ig-114 64 None 0.071 None 0.915 N 0.653 0.26 0.408853032482 gnomAD-4.0.0 6.84583E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99866E-07 0 0
S/G 18031 Ig-114 64 rs397517615 0.1077 -1.107 0.211 N 0.641 0.122 0.243398259712 gnomAD-2.1.1 8.07E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 1.66058E-04
S/G 18031 Ig-114 64 rs397517615 0.1077 -1.107 0.211 N 0.641 0.122 0.243398259712 gnomAD-3.1.2 3.95E-05 None None None None N None 0 3.93856E-04 0 0 0 None 0 0 0 0 0
S/G 18031 Ig-114 64 rs397517615 0.1077 -1.107 0.211 N 0.641 0.122 0.243398259712 gnomAD-4.0.0 8.0608E-06 None None None None N None 1.33615E-05 1.0011E-04 None 0 0 None 0 0 1.69603E-06 0 6.4082E-05
S/T 18031 Ig-114 64 rs1259446367 0.0598 -0.655 0.002 N 0.528 0.116 0.0806252709748 gnomAD-2.1.1 1.21E-05 None None None None N None 6.47E-05 2.9E-05 None 0 0 None 0 None 0 8.94E-06 0
S/T 18031 Ig-114 64 rs1259446367 0.0598 -0.655 0.002 N 0.528 0.116 0.0806252709748 gnomAD-4.0.0 4.78001E-06 None None None None N None 5.67537E-05 2.28749E-05 None 0 0 None 0 0 2.86243E-06 0 0
I/V 18445 Ig-115 64 None 0.0763 None None N 0.231 0.072 0.319970858106 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
E/K 19445 Ig-118 55 rs1418076473 0.2052 1.483 0.081 N 0.562 0.167 0.307016933798 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
E/K 19445 Ig-118 55 rs1418076473 0.2052 1.483 0.081 N 0.562 0.167 0.307016933798 gnomAD-4.0.0 4.79018E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29684E-06 0 0
E/K 19843 Ig-119 54 rs1185186867 0.6349 -1.34 0.99 N 0.621 0.341 0.415055319159 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
E/K 19843 Ig-119 54 rs1185186867 0.6349 -1.34 0.99 N 0.621 0.341 0.415055319159 gnomAD-4.0.0 5.47452E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19664E-06 0 0
T/N 20137 Ig-120 58 rs747842187 0.1764 -1.312 0.961 N 0.647 0.398 0.402755899245 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/N 20137 Ig-120 58 rs747842187 0.1764 -1.312 0.961 N 0.647 0.398 0.402755899245 gnomAD-4.0.0 2.56398E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78962E-06 0 0
S/Y 20830 Ig-122 62 None 0.1221 None 0.602 N 0.643 0.226 0.361758802978 gnomAD-4.0.0 1.59178E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85917E-06 0 0
V/I 21232 Ig-123 56 rs767582181 0.0991 -0.28 0.767 N 0.321 0.185 0.474248596982 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
V/I 21232 Ig-123 56 rs767582181 0.0991 -0.28 0.767 N 0.321 0.185 0.474248596982 gnomAD-4.0.0 6.84705E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99748E-07 0 0
V/L 21232 Ig-123 56 None 0.2818 None 0.981 N 0.438 0.262 0.593771126905 gnomAD-4.0.0 6.84705E-07 None None None None I None 2.9915E-05 0 None 0 0 None 0 0 0 0 0
R/C 22320 Ig-126 56 rs772361876 0.2236 -1.329 0.998 N 0.475 0.508 0.686686103294 gnomAD-2.1.1 2.01E-05 None None None None N None 0 2.9E-05 None 0 0 None 9.81E-05 None 0 8.91E-06 0
R/C 22320 Ig-126 56 rs772361876 0.2236 -1.329 0.998 N 0.475 0.508 0.686686103294 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94326E-04 None 0 0 0 0 0
R/C 22320 Ig-126 56 rs772361876 0.2236 -1.329 0.998 N 0.475 0.508 0.686686103294 gnomAD-4.0.0 1.92173E-05 None None None None N None 4.00149E-05 1.66706E-05 None 0 2.23604E-05 None 0 0 1.44136E-05 8.78677E-05 1.60133E-05
R/H 22320 Ig-126 56 rs771424865 0.1355 -1.876 0.017 N 0.325 0.317 None gnomAD-2.1.1 3.93E-05 None None None None N None 4.13E-05 8.49E-05 None 0 5.16E-05 None 0 None 4E-05 3.92E-05 0
R/H 22320 Ig-126 56 rs771424865 0.1355 -1.876 0.017 N 0.325 0.317 None gnomAD-3.1.2 4.6E-05 None None None None N None 7.24E-05 2.6202E-04 0 0 0 None 0 0 0 0 0
R/H 22320 Ig-126 56 rs771424865 0.1355 -1.876 0.017 N 0.325 0.317 None gnomAD-4.0.0 2.72773E-05 None None None None N None 9.35054E-05 1.16713E-04 None 0 2.23524E-05 None 1.56314E-05 1.64636E-04 2.2892E-05 0 0
R/L 22320 Ig-126 56 None 0.3208 None 0.336 N 0.433 0.391 0.474798811001 gnomAD-4.0.0 1.3689E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79941E-06 0 0
I/M 22609 Ig-127 50 rs751153093 0.0792 -0.927 0.033 N 0.47 0.047 0.37762505005 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.8E-05 None 0 0 0
I/M 22609 Ig-127 50 rs751153093 0.0792 -0.927 0.033 N 0.47 0.047 0.37762505005 gnomAD-4.0.0 8.89618E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49803E-06 9.27601E-05 0
I/R 22609 Ig-127 50 None 0.2559 None 0.033 N 0.538 0.184 0.654130084499 gnomAD-4.0.0 6.8433E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99617E-07 0 0
I/T 22609 Ig-127 50 rs778337241 0.0974 -1.912 None N 0.259 0.108 0.632468194898 gnomAD-2.1.1 2.41E-05 None None None None N None 6.46E-05 0 None 0 0 None 1.30727E-04 None 0 0 1.65563E-04
I/T 22609 Ig-127 50 rs778337241 0.0974 -1.912 None N 0.259 0.108 0.632468194898 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/T 22609 Ig-127 50 rs778337241 0.0974 -1.912 None N 0.259 0.108 0.632468194898 gnomAD-4.0.0 1.61156E-05 None None None None N None 1.33551E-05 0 None 0 0 None 0 0 1.69555E-06 2.41572E-04 1.60149E-05
T/A 23006 Ig-128 57 rs763118646 0.0897 -1.267 None N 0.199 0.136 0.0482279557977 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/A 23006 Ig-128 57 rs763118646 0.0897 -1.267 None N 0.199 0.136 0.0482279557977 gnomAD-4.0.0 1.59209E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85971E-06 0 0
T/I 23006 Ig-128 57 rs1559470479 0.1381 None 0.029 N 0.584 0.11 0.209622950755 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/I 23006 Ig-128 57 rs1559470479 0.1381 None 0.029 N 0.584 0.11 0.209622950755 gnomAD-4.0.0 1.59211E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85976E-06 0 0
N/H 23692 Ig-130 56 rs780578913 0.074 -1.397 0.994 N 0.683 0.339 0.417081434665 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
N/H 23692 Ig-130 56 rs780578913 0.074 -1.397 0.994 N 0.683 0.339 0.417081434665 gnomAD-4.0.0 3.4218E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49792E-06 0 0
N/S 23692 Ig-130 56 rs1575796679 0.0877 None 0.805 N 0.571 0.094 0.207176502487 gnomAD-4.0.0 1.59208E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85943E-06 0 0
V/A 24088 Ig-131 60 rs774226045 0.1502 -2.817 0.027 N 0.627 0.181 0.351180957027 gnomAD-2.1.1 1.16869E-04 None None None None N None 0 0 None 0 0 None 9.51568E-04 None 0 0 0
V/A 24088 Ig-131 60 rs774226045 0.1502 -2.817 0.027 N 0.627 0.181 0.351180957027 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
V/A 24088 Ig-131 60 rs774226045 0.1502 -2.817 0.027 N 0.627 0.181 0.351180957027 gnomAD-4.0.0 4.4693E-05 None None None None N None 0 0 None 0 0 None 0 0 0 7.80632E-04 1.60467E-05
V/E 24088 Ig-131 60 None 0.2169 None 0.317 N 0.646 0.218 0.618265897142 gnomAD-4.0.0 2.05633E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70305E-06 0 0
I/T 24485 Ig-132 55 rs1708656182 0.1163 None None N 0.26 0.105 0.518312163451 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
I/T 24485 Ig-132 55 rs1708656182 0.1163 None None N 0.26 0.105 0.518312163451 gnomAD-4.0.0 6.57402E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.06954E-04 0
S/I 25170 Ig-134 60 rs1355222139 0.0737 0.072 0.003 N 0.447 0.311 0.375861065471 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/I 25170 Ig-134 60 rs1355222139 0.0737 0.072 0.003 N 0.447 0.311 0.375861065471 gnomAD-4.0.0 3.18383E-06 None None None None N None 0 4.57415E-05 None 0 0 None 0 0 0 0 0
S/R 25170 Ig-134 60 rs775835843 0.3745 -0.205 0.427 N 0.542 0.329 0.143124449307 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
S/R 25170 Ig-134 60 rs775835843 0.3745 -0.205 0.427 N 0.542 0.329 0.143124449307 gnomAD-4.0.0 6.84329E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99569E-07 0 0
V/F 25567 Ig-135 54 rs3813244 0.2412 -1.217 1.0 D 0.793 0.379 None gnomAD-2.1.1 2.07653E-04 None None None None N None 0 0 None 0 2.99E-03 None 0 None 0 0 0
V/F 25567 Ig-135 54 rs3813244 0.2412 -1.217 1.0 D 0.793 0.379 None gnomAD-3.1.2 1.18356E-04 None None None None N None 0 0 0 0 3.48297E-03 None 0 0 0 0 0
V/F 25567 Ig-135 54 rs3813244 0.2412 -1.217 1.0 D 0.793 0.379 None 1000 genomes 5.99042E-04 None None None None N None 0 0 None None 3E-03 0 None None None 0 None
V/F 25567 Ig-135 54 rs3813244 0.2412 -1.217 1.0 D 0.793 0.379 None gnomAD-4.0.0 1.45048E-04 None None None None N None 0 0 None 0 5.1832E-03 None 0 0 0 0 3.20205E-05
V/I 25567 Ig-135 54 None 0.0836 None 0.997 N 0.5 0.195 0.66885242914 gnomAD-4.0.0 6.84436E-07 None None None None N None 0 0 None 0 2.525E-05 None 0 0 0 0 0
S/G 25856 Ig-136 59 None 0.1125 None 0.09 N 0.545 0.147 0.252681307341 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/N 25856 Ig-136 59 None 0.074 None 0.001 N 0.252 0.091 0.139678290688 gnomAD-4.0.0 3.18377E-06 None None None None N None 0 0 None 4.76963E-05 0 None 0 0 0 1.43312E-05 0
I/T 26252 Ig-137 60 None 0.0841 None 0.013 N 0.313 0.183 0.617987307765 gnomAD-4.0.0 4.85157E-06 None None None None N None 0 0 None 0 0 None 0 0 6.33639E-06 0 0
H/P 26938 Ig-139 59 None 0.7943 None 0.917 D 0.533 0.384 0.380052290102 gnomAD-4.0.0 1.59155E-06 None None None None N None 0 0 None 0 2.77331E-05 None 0 0 0 0 0
H/Q 26938 Ig-139 59 rs1173826868 0.1508 -0.499 0.642 N 0.397 0.197 0.206339911435 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
H/Q 26938 Ig-139 59 rs1173826868 0.1508 -0.499 0.642 N 0.397 0.197 0.206339911435 gnomAD-4.0.0 6.84268E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99548E-07 0 0
V/G 27335 Ig-140 58 rs1211654508 0.1827 -2.44 0.055 N 0.617 0.278 0.632689300127 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
V/G 27335 Ig-140 58 rs1211654508 0.1827 -2.44 0.055 N 0.617 0.278 0.632689300127 gnomAD-4.0.0 1.59125E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8584E-06 0 0
V/L 27732 Ig-141 57 None 0.3687 None 0.981 N 0.4 0.289 0.598875534596 gnomAD-4.0.0 1.36856E-06 None None None None N None 0 0 None 0 0 None 0 0 1.799E-06 0 0
V/M 27732 Ig-141 57 rs1332933880 0.2902 -0.497 0.981 N 0.384 0.304 0.61117527565 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
V/M 27732 Ig-141 57 rs1332933880 0.2902 -0.497 0.981 N 0.384 0.304 0.61117527565 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/M 27732 Ig-141 57 rs1332933880 0.2902 -0.497 0.981 N 0.384 0.304 0.61117527565 gnomAD-4.0.0 1.42547E-05 None None None None N None 0 0 None 0 0 None 0 0 1.94958E-05 0 0
S/C 28021 Ig-142 59 None 0.0714 None 0.196 N 0.453 0.095 0.209622950755 gnomAD-4.0.0 1.59246E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43357E-05 0
S/P 28021 Ig-142 59 None 0.8715 None 0.065 N 0.493 0.144 0.0666544352282 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
T/S 28811 Ig-144 57 rs775103234 0.123 -1.037 0.775 N 0.291 0.18 0.286081765059 gnomAD-2.1.1 8.24E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.82E-05 0
T/S 28811 Ig-144 57 rs775103234 0.123 -1.037 0.775 N 0.291 0.18 0.286081765059 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
T/S 28811 Ig-144 57 rs775103234 0.123 -1.037 0.775 N 0.291 0.18 0.286081765059 gnomAD-4.0.0 1.60637E-06 None None None None N None 0 0 None 0 0 None 0 0 2.88344E-06 0 0
N/S 29103 Ig-145 59 rs375374455 0.0733 -0.86 0.514 N 0.526 0.178 None gnomAD-2.1.1 8.04E-06 None None None None N None 1.29149E-04 0 None 0 0 None 0 None 0 0 0
N/S 29103 Ig-145 59 rs375374455 0.0733 -0.86 0.514 N 0.526 0.178 None gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
N/S 29103 Ig-145 59 rs375374455 0.0733 -0.86 0.514 N 0.526 0.178 None gnomAD-4.0.0 4.33748E-06 None None None None N None 5.33803E-05 0 None 0 0 None 0 0 1.69511E-06 0 1.60087E-05
L/F 29499 Ig-146 56 rs968816753 0.0858 None 0.007 N 0.299 0.142 0.422762650823 gnomAD-4.0.0 1.59147E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85804E-06 0 0
L/R 29499 Ig-146 56 rs72648234 0.1698 -0.882 0.939 N 0.564 0.433 None gnomAD-2.1.1 1.42956E-04 None None None None N None 4.13E-05 0 None 0 0 None 0 None 0 3.04983E-04 0
L/R 29499 Ig-146 56 rs72648234 0.1698 -0.882 0.939 N 0.564 0.433 None gnomAD-3.1.2 9.2E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.76382E-04 0 0
L/R 29499 Ig-146 56 rs72648234 0.1698 -0.882 0.939 N 0.564 0.433 None gnomAD-4.0.0 1.56789E-04 None None None None N None 4.00481E-05 0 None 0 0 None 1.56294E-05 0 2.0342E-04 0 1.44125E-04
F/C 30585 Ig-149 54 None 0.4464 None 1.0 N 0.789 0.529 0.822920202348 gnomAD-4.0.0 1.59128E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
F/S 30585 Ig-149 54 rs927256604 0.4555 -1.97 1.0 N 0.787 0.585 0.820560963796 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
F/S 30585 Ig-149 54 rs927256604 0.4555 -1.97 1.0 N 0.787 0.585 0.820560963796 gnomAD-4.0.0 1.59128E-06 None None None None N None 5.65675E-05 0 None 0 0 None 0 0 0 0 0
F/V 30585 Ig-149 54 rs1060500507 0.304 -1.846 1.0 N 0.713 0.512 0.828163162091 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
F/V 30585 Ig-149 54 rs1060500507 0.304 -1.846 1.0 N 0.713 0.512 0.828163162091 gnomAD-4.0.0 1.59127E-06 None None None None N None 0 0 None 0 2.77316E-05 None 0 0 0 0 0
T/N 31274 Ig-151 57 None 0.112 None 0.062 D 0.505 0.173 0.329282125956 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 31674 Ig-152 54 rs754222897 0.2656 -1.798 0.78 N 0.579 0.4 0.665537837766 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.66E-05 0
V/A 31674 Ig-152 54 rs754222897 0.2656 -1.798 0.78 N 0.579 0.4 0.665537837766 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 31674 Ig-152 54 rs754222897 0.2656 -1.798 0.78 N 0.579 0.4 0.665537837766 gnomAD-4.0.0 8.67537E-06 None None None None N None 0 0 None 0 0 None 0 8.22639E-04 6.78084E-06 0 1.60108E-05
V/L 31674 Ig-152 54 rs1559147307 0.1634 None 0.437 N 0.41 0.211 0.451786746415 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/R 32071 Ig-153 55 rs755545981 0.5543 -1.072 0.794 N 0.684 0.306 0.792153859373 gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
I/R 32071 Ig-153 55 rs755545981 0.5543 -1.072 0.794 N 0.684 0.306 0.792153859373 gnomAD-3.1.2 1.97E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 2.94E-05 0 0
I/R 32071 Ig-153 55 rs755545981 0.5543 -1.072 0.794 N 0.684 0.306 0.792153859373 gnomAD-4.0.0 8.67651E-06 None None None None N None 1.3359E-05 0 None 0 0 None 0 0 1.10196E-05 0 0
I/T 32071 Ig-153 55 rs755545981 0.1626 -2.261 0.003 N 0.398 0.159 0.520640030592 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/T 32071 Ig-153 55 rs755545981 0.1626 -2.261 0.003 N 0.398 0.159 0.520640030592 gnomAD-3.1.2 1.97E-05 None None None None N None 0 6.56E-05 0 0 0 None 0 3.16456E-03 0 0 4.78011E-04
I/T 32071 Ig-153 55 rs755545981 0.1626 -2.261 0.003 N 0.398 0.159 0.520640030592 gnomAD-4.0.0 3.09853E-06 None None None None N None 0 1.66694E-05 None 0 0 None 0 0 8.4767E-07 2.19597E-05 1.60067E-05
T/I 32365 Ig-154 59 None 0.127 None 0.028 N 0.481 0.275 0.424194796918 gnomAD-4.0.0 1.59123E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85829E-06 0 0
T/S 32365 Ig-154 59 None 0.1198 None 0.028 N 0.463 0.157 0.247322355667 gnomAD-4.0.0 3.18246E-06 None None None None N None 0 0 None 0 2.77285E-05 None 0 0 2.85829E-06 0 0
V/I 33255 Ig-157 53 rs1692136701 0.0997 None 0.002 N 0.411 0.071 0.515259903717 gnomAD-4.0.0 7.96536E-06 None None None None N None 0 0 None 0 2.77809E-05 None 0 0 0 0 1.21051E-04
I/L 33556 Ig-158 61 None 0.2731 None 0.006 N 0.447 0.202 0.346768085243 gnomAD-4.0.0 1.68175E-05 None None None None N None 6.34035E-05 0 None 0 0 None 0 0 1.70755E-05 0 0
V/A 33654 Ig-159 59 None 0.8118 None 1.0 N 0.542 0.501 0.618519337204 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Y/C 34195 Ig-160 59 None 0.1878 None 0.999 D 0.665 0.385 0.622351988405 gnomAD-4.0.0 3.18197E-06 None None None None N None 0 0 None 0 2.77254E-05 None 0 0 2.85767E-06 0 0
T/A 34319 Ig-161 62 rs768829243 0.1437 -1.575 0.148 N 0.536 0.096 0.185906805712 gnomAD-2.1.1 1.21E-05 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 8.87E-06 0
T/A 34319 Ig-161 62 rs768829243 0.1437 -1.575 0.148 N 0.536 0.096 0.185906805712 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/A 34319 Ig-161 62 rs768829243 0.1437 -1.575 0.148 N 0.536 0.096 0.185906805712 gnomAD-4.0.0 8.67492E-06 None None None None N None 0 3.33367E-05 None 0 0 None 0 0 8.47552E-06 0 3.20164E-05
T/I 34319 Ig-161 62 rs549304089 0.1202 -0.192 None N 0.353 0.148 0.209622950755 gnomAD-2.1.1 6.03E-05 None None None None N None 0 0 None 0 5.57E-05 None 4.57546E-04 None 0 0 0
T/I 34319 Ig-161 62 rs549304089 0.1202 -0.192 None N 0.353 0.148 0.209622950755 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 1.9253E-04 None 0 0 0 2.07039E-04 0
T/I 34319 Ig-161 62 rs549304089 0.1202 -0.192 None N 0.353 0.148 0.209622950755 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
T/I 34319 Ig-161 62 rs549304089 0.1202 -0.192 None N 0.353 0.148 0.209622950755 gnomAD-4.0.0 2.23062E-05 None None None None N None 0 0 None 0 2.22826E-05 None 0 0 0 3.84269E-04 0
H/Q 34422 Ig-162 60 None 0.6568 None 0.989 N 0.531 0.354 0.396645960531 gnomAD-4.0.0 6.84291E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99413E-07 0 0
E/D 35000 Ig-163 59 rs866303280 0.3339 None 0.826 N 0.534 0.21 0.324986149311 gnomAD-4.0.0 3.1818E-06 None None None None N None 0 0 None 0 0 None 0 2.4108E-04 0 0 3.02334E-05
E/G 35000 Ig-163 59 None 0.7287 None 0.959 D 0.546 0.352 0.452264262256 gnomAD-4.0.0 1.5909E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
T/S 35663 Ig-167 57 None 0.2039 None 0.999 N 0.526 0.458 0.33835085245 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 3.66327E-05
I/F 35957 Ig-169 61 rs950902715 0.6059 -1.717 0.071 N 0.453 0.274 0.46017455471 gnomAD-2.1.1 4.01E-06 None None None -0.247(OBSL1) -0.452(OBSCN) N None 0 0 None 0 0 None 0 None 0 8.85E-06 0
I/F 35957 Ig-169 61 rs950902715 0.6059 -1.717 0.071 N 0.453 0.274 0.46017455471 gnomAD-3.1.2 1.31E-05 None None None -0.247(OBSL1) -0.452(OBSCN) N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/F 35957 Ig-169 61 rs950902715 0.6059 -1.717 0.071 N 0.453 0.274 0.46017455471 gnomAD-4.0.0 2.91226E-05 None None None -0.247(OBSL1) -0.452(OBSCN) N None 0 0 None 0 0 None 0 0 3.98348E-05 0 0
I/M 35957 Ig-169 61 None 0.2911 None 0.998 D 0.614 0.286 0.646296243553 gnomAD-4.0.0 6.84147E-07 None None None -0.749(OBSL1) -0.739(OBSCN) N None 0 0 None 0 2.51927E-05 None 0 0 0 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.