Structural position:

  • Domain Type: Ig
  • Aligned Position: 141
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand E

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
P/S 68 Ig-1 63 rs876658046 0.1723 None 0.021 N 0.185 0.193 0.190952846119 gnomAD-3.1.2 6.57E-06 None None None -0.255(TCAP) N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
P/S 68 Ig-1 63 rs876658046 0.1723 None 0.021 N 0.185 0.193 0.190952846119 gnomAD-4.0.0 9.2937E-06 None None None -0.255(TCAP) N None 1.33486E-05 0 None 0 0 None 0 0 1.1017E-05 0 1.60046E-05
A/V 164 Ig-2 61 rs140166195 0.4402 -0.374 0.918 N 0.563 0.274 None gnomAD-2.1.1 7.95E-06 None None None -0.478(TCAP) N None 6.15E-05 0 None 0 0 None 0 None 4.62E-05 0 0
A/V 164 Ig-2 61 rs140166195 0.4402 -0.374 0.918 N 0.563 0.274 None gnomAD-4.0.0 1.59045E-06 None None None -0.478(TCAP) N None 0 0 None 0 0 None 1.88175E-05 0 0 0 0
R/C 1003 Ig-3 61 rs774551765 0.7365 -0.335 1.0 D 0.702 0.54 0.815244402667 gnomAD-2.1.1 1.2E-05 None None None None N None 0 2.89E-05 None 0 5.45E-05 None 0 None 0 8.83E-06 0
R/C 1003 Ig-3 61 rs774551765 0.7365 -0.335 1.0 D 0.702 0.54 0.815244402667 gnomAD-3.1.2 1.31E-05 None None None None N None 0 6.54E-05 0 0 0 None 0 0 0 0 4.77555E-04
R/C 1003 Ig-3 61 rs774551765 0.7365 -0.335 1.0 D 0.702 0.54 0.815244402667 gnomAD-4.0.0 2.72623E-05 None None None None N None 0 9.99867E-05 None 0 2.22856E-05 None 0 0 2.62712E-05 1.09786E-05 8.00256E-05
R/H 1003 Ig-3 61 rs1330606775 0.3925 -1.108 1.0 N 0.723 0.442 0.419461527279 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
R/H 1003 Ig-3 61 rs1330606775 0.3925 -1.108 1.0 N 0.723 0.442 0.419461527279 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/H 1003 Ig-3 61 rs1330606775 0.3925 -1.108 1.0 N 0.723 0.442 0.419461527279 gnomAD-4.0.0 4.9568E-06 None None None None N None 1.33511E-05 0 None 0 0 None 0 0 4.23732E-06 2.19578E-05 0
R/S 1003 Ig-3 61 rs774551765 0.9065 None 1.0 N 0.692 0.494 0.540107908424 gnomAD-4.0.0 1.36817E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79862E-06 0 0
S/P 1144 Ig-4 63 None 0.8782 None 1.0 N 0.673 0.706 0.530211221528 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
P/L 1352 Ig-5 62 rs756380712 0.4378 -0.561 0.896 N 0.565 0.488 0.786516960604 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.84E-06 0
P/L 1352 Ig-5 62 rs756380712 0.4378 -0.561 0.896 N 0.565 0.488 0.786516960604 gnomAD-4.0.0 1.59079E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85688E-06 0 0
P/S 1352 Ig-5 62 None 0.2858 None 0.211 N 0.295 0.227 0.286848849266 gnomAD-4.0.0 6.84116E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99332E-07 0 0
P/T 1352 Ig-5 62 None 0.344 None 0.811 N 0.488 0.279 0.531437074999 gnomAD-4.0.0 2.05235E-06 None None None None N None 0 0 None 0 0 None 0 0 2.698E-06 0 0
V/A 1518 Ig-6 62 rs752482916 0.6511 -0.71 0.334 N 0.441 0.229 None gnomAD-4.0.0 1.2448E-04 None None None None N None 0 4.59664E-05 None 9.54198E-05 3.06629E-04 None 8.38447E-04 2.41429E-04 4.86718E-05 0 3.03453E-05
V/F 1518 Ig-6 62 rs755962102 0.5059 -0.85 0.638 N 0.647 0.29 0.809845328503 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.84E-06 0
V/F 1518 Ig-6 62 rs755962102 0.5059 -0.85 0.638 N 0.647 0.29 0.809845328503 gnomAD-4.0.0 1.59128E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85722E-06 0 0
V/I 1518 Ig-6 62 None 0.1302 -0.206 0.002 N 0.231 0.069 0.528260413467 gnomAD-2.1.1 7.1E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.56E-05 0
V/I 1518 Ig-6 62 None 0.1302 -0.206 0.002 N 0.231 0.069 0.528260413467 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
V/I 1518 Ig-6 62 None 0.1302 -0.206 0.002 N 0.231 0.069 0.528260413467 gnomAD-4.0.0 6.40553E-06 None None None None N None 0 0 None 0 0 None 0 0 1.19609E-05 0 0
D/G 1618 Ig-7 63 rs1324756385 0.2255 None 0.521 N 0.341 0.288 0.259761712551 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/G 1618 Ig-7 63 rs1324756385 0.2255 None 0.521 N 0.341 0.288 0.259761712551 gnomAD-4.0.0 2.02977E-06 None None None None N None 3.49394E-05 0 None 0 0 None 0 0 0 0 0
D/H 1618 Ig-7 63 None 0.3641 None 0.975 N 0.401 0.209 0.3085936734 gnomAD-4.0.0 6.84134E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99313E-07 0 0
D/N 1618 Ig-7 63 rs794727465 0.1271 -0.135 0.037 N 0.18 0.118 0.184867976434 gnomAD-2.1.1 7.12E-06 None None None None N None 4.12E-05 0 None 0 0 None 0 None 0 7.79E-06 0
D/N 1618 Ig-7 63 rs794727465 0.1271 -0.135 0.037 N 0.18 0.118 0.184867976434 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 1618 Ig-7 63 rs794727465 0.1271 -0.135 0.037 N 0.18 0.118 0.184867976434 gnomAD-4.0.0 4.33748E-06 None None None None N None 0 0 None 0 0 None 0 0 5.93222E-06 0 0
D/Y 1618 Ig-7 63 rs794727465 0.3129 None 0.992 N 0.455 0.333 0.673333262281 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/Y 1618 Ig-7 63 rs794727465 0.3129 None 0.992 N 0.455 0.333 0.673333262281 gnomAD-4.0.0 1.23928E-06 None None None None N None 1.33522E-05 0 None 0 0 None 0 0 0 0 1.60061E-05
G/A 1765 Ig-8 63 None 0.1039 None None N 0.095 0.083 0.0666544352282 gnomAD-4.0.0 6.84403E-07 None None None None I None 0 2.23634E-05 None 0 0 None 0 0 0 0 0
G/D 1765 Ig-8 63 rs2092251339 0.397 None None N 0.145 0.152 0.0884992946249 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
G/D 1765 Ig-8 63 rs2092251339 0.397 None None N 0.145 0.152 0.0884992946249 gnomAD-4.0.0 1.2397E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.09789E-05 1.60061E-05
G/R 1765 Ig-8 63 None 0.3995 None 0.055 N 0.427 0.237 0.547384771329 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
V/G 1900 Ig-9 60 rs878931921 0.5981 None 0.961 N 0.553 0.502 None gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
V/L 1900 Ig-9 60 None 0.4411 None 0.963 N 0.457 0.221 0.455909487837 gnomAD-4.0.0 1.02611E-05 None None None None N None 0 0 None 0 0 None 0 0 1.25902E-05 0 1.65579E-05
V/M 1900 Ig-9 60 rs750823043 0.3527 -1.183 1.0 N 0.475 0.274 None gnomAD-2.1.1 2.48E-05 None None None None N None 4.01E-05 0 None 0 1.00261E-04 None 3.27E-05 None 0 2.33E-05 0
V/M 1900 Ig-9 60 rs750823043 0.3527 -1.183 1.0 N 0.475 0.274 None gnomAD-3.1.2 3.29E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 2.06954E-04 4.77555E-04
V/M 1900 Ig-9 60 rs750823043 0.3527 -1.183 1.0 N 0.475 0.274 None gnomAD-4.0.0 2.47831E-05 None None None None N None 1.06795E-04 0 None 3.37769E-05 6.683E-05 None 0 1.64366E-04 1.01695E-05 8.78252E-05 1.12022E-04
R/T 2139 Ig-10 62 rs1250660325 0.5983 None 1.0 N 0.685 0.512 0.507331908393 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
R/T 2139 Ig-10 62 rs1250660325 0.5983 None 1.0 N 0.685 0.512 0.507331908393 gnomAD-4.0.0 6.57333E-06 None None None None N None 0 6.5505E-05 None 0 0 None 0 0 0 0 0
L/M 2234 Ig-11 61 rs766750289 0.1556 -1.237 0.999 N 0.711 0.194 0.625654597223 gnomAD-2.1.1 1.59E-05 None None None None N None 0 0 None 3.97141E-04 0 None 0 None 0 0 0
L/M 2234 Ig-11 61 rs766750289 0.1556 -1.237 0.999 N 0.711 0.194 0.625654597223 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 5.76369E-04 0 None 0 0 0 0 0
L/M 2234 Ig-11 61 rs766750289 0.1556 -1.237 0.999 N 0.711 0.194 0.625654597223 gnomAD-4.0.0 4.33727E-06 None None None None N None 1.33461E-05 0 None 1.6893E-04 0 None 0 0 8.47485E-07 0 0
L/P 2234 Ig-11 61 rs534604830 0.7984 -1.48 0.999 N 0.805 0.613 0.838109445121 gnomAD-2.1.1 7.96E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 8.81E-06 0
L/P 2234 Ig-11 61 rs534604830 0.7984 -1.48 0.999 N 0.805 0.613 0.838109445121 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/P 2234 Ig-11 61 rs534604830 0.7984 -1.48 0.999 N 0.805 0.613 0.838109445121 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
L/P 2234 Ig-11 61 rs534604830 0.7984 -1.48 0.999 N 0.805 0.613 0.838109445121 gnomAD-4.0.0 2.56096E-06 None None None None N None 0 1.694E-05 None 0 0 None 0 0 2.39202E-06 0 0
L/Q 2234 Ig-11 61 None 0.2994 None 0.993 N 0.809 0.451 0.833376837834 gnomAD-4.0.0 1.59084E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
E/D 2415 Ig-13 60 None 0.5991 None 0.999 N 0.415 0.274 0.242825505644 gnomAD-4.0.0 3.18109E-06 None None None None N None 0 0 None 4.76554E-05 0 None 1.88175E-05 0 0 0 0
E/V 2415 Ig-13 60 rs1462312746 0.7958 None 1.0 N 0.631 0.625 0.678036545427 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/V 2415 Ig-13 60 rs1462312746 0.7958 None 1.0 N 0.631 0.625 0.678036545427 gnomAD-4.0.0 4.95669E-06 None None None None N None 0 0 None 0 0 None 0 0 6.77971E-06 0 0
N/K 2505 Ig-14 61 None 0.3514 None 0.801 N 0.347 0.15 0.146414634003 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/Y 2505 Ig-14 61 None 0.161 None 0.989 N 0.511 0.412 0.620613072855 gnomAD-4.0.0 1.59068E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85677E-06 0 0
L/I 2592 Ig-15 60 None 0.0712 None 0.005 N 0.093 0.091 0.350746614512 gnomAD-4.0.0 1.59125E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85724E-06 0 0
A/T 2679 Ig-16 59 rs762303238 0.0735 -0.788 0.001 N 0.103 0.1 0.191931220699 gnomAD-2.1.1 7.96E-06 None None None None N None 0 0 None 0 0 None 0 None 9.24E-05 0 0
A/T 2679 Ig-16 59 rs762303238 0.0735 -0.788 0.001 N 0.103 0.1 0.191931220699 gnomAD-4.0.0 6.36236E-06 None None None None N None 0 0 None 0 0 None 3.76378E-05 0 5.71314E-06 0 0
K/N 2767 Ig-17 61 None 0.3327 None 0.733 N 0.256 0.161 0.188950314367 gnomAD-4.0.0 1.59052E-06 None None None None N None 0 0 None 0 2.77362E-05 None 0 0 0 0 0
K/R 2767 Ig-17 61 None 0.0794 None 0.217 N 0.281 0.225 0.247322355667 gnomAD-4.0.0 1.59051E-06 None None None None N None 5.65163E-05 0 None 0 0 None 0 0 0 0 0
Q/H 2854 Ig-18 60 None 0.2271 None 0.028 N 0.164 0.271 0.238096912614 gnomAD-4.0.0 6.84063E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65574E-05
Q/R 2854 Ig-18 60 rs750346528 0.1396 None 0.801 N 0.413 0.317 0.231873229951 gnomAD-4.0.0 1.59047E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02133E-05
M/L 2941 Ig-19 60 None 0.1762 None 0.005 N 0.122 0.242 0.526842377483 gnomAD-4.0.0 1.59049E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85656E-06 0 0
M/T 2941 Ig-19 60 rs766700696 0.3436 -0.546 0.801 N 0.315 0.47 0.78743447906 gnomAD-2.1.1 7.09E-06 None None None None N None 4.01E-05 2.82E-05 None 0 0 None 0 None 0 0 0
M/T 2941 Ig-19 60 rs766700696 0.3436 -0.546 0.801 N 0.315 0.47 0.78743447906 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
M/T 2941 Ig-19 60 rs766700696 0.3436 -0.546 0.801 N 0.315 0.47 0.78743447906 gnomAD-4.0.0 5.12315E-06 None None None None N None 3.38535E-05 3.38983E-05 None 0 0 None 0 0 0 0 0
M/V 2941 Ig-19 60 rs1344696996 0.1551 -0.722 0.022 N 0.112 0.279 0.431712495121 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.63345E-04
M/V 2941 Ig-19 60 rs1344696996 0.1551 -0.722 0.022 N 0.112 0.279 0.431712495121 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 4.78469E-04
M/V 2941 Ig-19 60 rs1344696996 0.1551 -0.722 0.022 N 0.112 0.279 0.431712495121 gnomAD-4.0.0 6.40323E-06 None None None None N None 1.69147E-05 0 None 0 0 None 0 2.24115E-04 2.39184E-06 0 5.68376E-05
P/L 3117 Ig-21 60 rs752062913 0.2376 None 0.379 N 0.473 0.298 0.577897453458 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
P/L 3117 Ig-21 60 rs752062913 0.2376 None 0.379 N 0.473 0.298 0.577897453458 gnomAD-4.0.0 1.85874E-06 None None None None N None 1.33472E-05 0 None 0 0 None 0 0 1.69489E-06 0 0
S/C 3208 Ig-22 62 None 0.1971 None 0.99 N 0.459 0.39 0.534572409765 gnomAD-4.0.0 1.59053E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
I/T 3299 Ig-23 61 rs2090024625 0.6267 None 1.0 N 0.599 0.585 0.739517929183 gnomAD-4.0.0 2.05222E-06 None None None None N None 0 0 None 0 2.51965E-05 None 0 0 8.99297E-07 0 1.65579E-05
A/D 3404 Ig-24 60 None 0.3255 None 0.976 N 0.477 0.499 0.756995558888 gnomAD-4.0.0 1.59076E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85693E-06 0 0
A/V 3404 Ig-24 60 rs1471749833 0.1392 -0.323 0.852 N 0.361 0.456 0.638558423614 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 5.45E-05 None 0 None 0 0 0
A/V 3404 Ig-24 60 rs1471749833 0.1392 -0.323 0.852 N 0.361 0.456 0.638558423614 gnomAD-4.0.0 3.18152E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 3.02224E-05
V/A 3527 Ig-25 63 rs1355094541 0.356 None None None None 0.206 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92382E-04 None 0 0 0 0 0
V/A 3527 Ig-25 63 rs1355094541 0.356 None None None None 0.206 None gnomAD-4.0.0 6.56901E-06 None None None None I None 0 0 None 0 1.92382E-04 None 0 0 0 0 0
V/F 3527 Ig-25 63 rs372531162 0.4504 -1.112 None None None 0.326 None gnomAD-2.1.1 9.56E-05 None None None None I None 3.44511E-04 0 None 0 0 None 0 None 0 0 0
V/F 3527 Ig-25 63 rs372531162 0.4504 -1.112 None None None 0.326 None gnomAD-3.1.2 7.89E-05 None None None None I None 2.89505E-04 0 0 0 0 None 0 0 0 0 0
V/F 3527 Ig-25 63 rs372531162 0.4504 -1.112 None None None 0.326 None gnomAD-4.0.0 9.91522E-06 None None None None I None 2.13544E-04 0 None 0 0 None 0 0 0 0 0
V/I 3527 Ig-25 63 None 0.1084 None None None None 0.263 None gnomAD-4.0.0 1.36846E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99512E-07 1.15947E-05 0
V/L 3527 Ig-25 63 rs372531162 0.4148 -0.443 None None None 0.242 None gnomAD-2.1.1 7.14E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.56E-05 0
V/L 3527 Ig-25 63 rs372531162 0.4148 -0.443 None None None 0.242 None gnomAD-4.0.0 5.47385E-06 None None None None I None 0 2.23624E-05 None 0 0 None 0 0 6.29658E-06 0 0
C/S 3720 Ig-26 61 rs1356555138 0.1324 -0.692 None None None 0.105 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
C/S 3720 Ig-26 61 rs1356555138 0.1324 -0.692 None None None 0.105 None gnomAD-4.0.0 1.36838E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.31863E-05 0
C/W 3720 Ig-26 61 None 0.2168 None None None None 0.07 None gnomAD-4.0.0 2.73683E-06 None None None None I None 0 0 None 0 0 None 0 0 0 4.63747E-05 0
L/V 3880 Ig-27 61 rs762132549 0.2028 -0.935 0.454 N 0.433 0.114 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 9.96E-05 0 None 0 None 0 0 0
L/V 3880 Ig-27 61 rs762132549 0.2028 -0.935 0.454 N 0.433 0.114 None gnomAD-4.0.0 1.59118E-06 None None None None N None 0 0 None 4.76644E-05 0 None 0 0 0 0 0
N/S 3999 Ig-28 62 rs199844346 0.1535 -0.404 0.023 N 0.105 0.067 None gnomAD-2.1.1 1.39462E-04 None None None None I None 0 1.41499E-04 None 3.87072E-04 0 None 0 None 0 2.34716E-04 0
N/S 3999 Ig-28 62 rs199844346 0.1535 -0.404 0.023 N 0.105 0.067 None gnomAD-3.1.2 9.86E-05 None None None None I None 0 2.61883E-04 0 2.88184E-04 0 None 0 0 1.32322E-04 0 4.78011E-04
N/S 3999 Ig-28 62 rs199844346 0.1535 -0.404 0.023 N 0.105 0.067 None gnomAD-4.0.0 7.8086E-05 None None None None I None 0 1.83315E-04 None 4.39189E-04 0 None 0 1.15512E-03 6.7807E-05 0 2.40085E-04
D/N 4664 Ig-29 59 rs767084399 0.0715 -0.919 None N 0.045 0.126 None gnomAD-2.1.1 4.18E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.19E-06 0
D/N 4664 Ig-29 59 rs767084399 0.0715 -0.919 None N 0.045 0.126 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.78469E-04
D/N 4664 Ig-29 59 rs767084399 0.0715 -0.919 None N 0.045 0.126 None gnomAD-4.0.0 6.27357E-06 None None None None N None 0 1.68982E-05 None 0 6.75007E-05 None 0 0 1.71365E-06 1.13173E-05 4.8752E-05
L/R 4760 Ig-30 61 rs2081864609 0.3455 None 0.81 N 0.49 0.295 0.782511395319 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
L/R 4760 Ig-30 61 rs2081864609 0.3455 None 0.81 N 0.49 0.295 0.782511395319 gnomAD-4.0.0 6.57151E-06 None None None None N None 2.41173E-05 0 None 0 0 None 0 0 0 0 0
L/V 4760 Ig-30 61 rs2081864970 0.2211 None 0.007 N 0.059 0.073 0.425615883737 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
L/V 4760 Ig-30 61 rs2081864970 0.2211 None 0.007 N 0.059 0.073 0.425615883737 gnomAD-4.0.0 6.57341E-06 None None None None N None 2.41418E-05 0 None 0 0 None 0 0 0 0 0
S/L 4855 Ig-31 61 None 0.0908 None 0.001 N 0.209 0.168 0.460526725402 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62502E-06 0 0
T/M 5042 Ig-33 62 rs1060500462 0.0824 None 0.004 N 0.213 0.087 0.210429274316 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
T/M 5042 Ig-33 62 rs1060500462 0.0824 None 0.004 N 0.213 0.087 0.210429274316 gnomAD-4.0.0 3.09861E-06 None None None None N None 1.33518E-05 0 None 0 0 None 0 0 3.39047E-06 0 0
T/R 5042 Ig-33 62 None 0.1118 None None N 0.145 0.264 0.168933306366 gnomAD-4.0.0 6.84223E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99488E-07 0 0
Y/C 5321 Ig-36 61 None 0.2202 None 0.999 N 0.476 0.484 0.635582896387 gnomAD-4.0.0 1.59131E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43299E-05 0
Y/C 5510 Ig-38 61 rs72648939 0.1705 -0.132 0.999 N 0.375 0.41 None gnomAD-2.1.1 2.21299E-03 None None None None I None 5.37501E-04 3.11579E-04 None 0 2.91122E-02 None 3.26947E-04 None 0 7.83E-05 1.26654E-03
Y/C 5510 Ig-38 61 rs72648939 0.1705 -0.132 0.999 N 0.375 0.41 None gnomAD-3.1.2 1.20257E-03 None None None None I None 5.54698E-04 2.61952E-04 0 0 2.79491E-02 None 0 0 2.94E-05 4.14594E-04 3.34288E-03
Y/C 5510 Ig-38 61 rs72648939 0.1705 -0.132 0.999 N 0.375 0.41 None 1000 genomes 6.78914E-03 None None None None I None 0 0 None None 3.37E-02 0 None None None 0 None
Y/C 5510 Ig-38 61 rs72648939 0.1705 -0.132 0.999 N 0.375 0.41 None gnomAD-4.0.0 8.30995E-04 None None None None I None 4.66331E-04 2.8339E-04 None 0 2.19729E-02 None 0 0 3.39052E-05 3.29424E-04 3.74568E-03
Y/F 5510 Ig-38 61 None 0.0894 None 0.959 N 0.374 0.261 0.400899426204 gnomAD-4.0.0 1.36852E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79897E-06 0 0
S/G 5790 Ig-41 61 rs777761828 0.0809 -1.163 None N 0.081 0.157 0.215109475489 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
S/R 5790 Ig-41 61 rs777761828 0.2304 -0.349 None N 0.227 0.252 0.243972157842 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
S/R 5790 Ig-41 61 rs777761828 0.2304 -0.349 None N 0.227 0.252 0.243972157842 gnomAD-4.0.0 1.59117E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85812E-06 0 0
S/T 5790 Ig-41 61 None 0.0705 None None N 0.092 0.11 0.177238962908 gnomAD-4.0.0 6.8419E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99455E-06 0 0
I/L 5883 Ig-42 61 rs1468000752 0.0743 -0.926 None N 0.061 0.092 0.335910606209 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 2.22618E-04 None 0 None 0 0 0
I/L 5883 Ig-42 61 rs1468000752 0.0743 -0.926 None N 0.061 0.092 0.335910606209 gnomAD-4.0.0 6.36659E-06 None None None None N None 0 0 None 0 1.10926E-04 None 0 0 0 0 0
S/N 5979 Ig-43 61 rs1188866592 0.0806 None 0.002 N 0.079 0.154 0.187945064343 gnomAD-4.0.0 1.5916E-06 None None None None N None 0 0 None 0 2.77331E-05 None 0 0 0 0 0
S/A 6166 Ig-45 62 None 0.0681 None 0.047 N 0.173 0.105 0.208000267992 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
T/A 6259 Ig-46 61 rs780049500 0.0669 -1.061 0.003 N 0.273 0.119 0.158396225186 gnomAD-2.1.1 1.00818E-04 None None None None N None 0 0 None 0 0 None 8.17367E-04 None 0 0 0
T/A 6259 Ig-46 61 rs780049500 0.0669 -1.061 0.003 N 0.273 0.119 0.158396225186 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
T/A 6259 Ig-46 61 rs780049500 0.0669 -1.061 0.003 N 0.273 0.119 0.158396225186 gnomAD-4.0.0 3.65663E-05 None None None None N None 0 0 None 0 0 None 0 0 0 6.25796E-04 3.20246E-05
T/N 6259 Ig-46 61 rs72648949 0.0767 -1.386 None N 0.121 0.089 0.276482976112 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/N 6259 Ig-46 61 rs72648949 0.0767 -1.386 None N 0.121 0.089 0.276482976112 gnomAD-4.0.0 6.84286E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
T/S 6259 Ig-46 61 rs72648949 0.0745 -1.471 None N 0.106 0.096 0.12205267543 gnomAD-2.1.1 3.08967E-03 None None None None N None 5.38302E-04 1.44394E-03 None 3.21172E-02 0 None 1.079E-03 None 3.59827E-04 3.11764E-03 4.07876E-03
T/S 6259 Ig-46 61 rs72648949 0.0745 -1.471 None N 0.106 0.096 0.12205267543 gnomAD-3.1.2 2.62369E-03 None None None None N None 3.13888E-04 3.92927E-03 0 2.76976E-02 0 None 4.71342E-04 9.49367E-03 2.9705E-03 1.44928E-03 6.2201E-03
T/S 6259 Ig-46 61 rs72648949 0.0745 -1.471 None N 0.106 0.096 0.12205267543 1000 genomes 5.99042E-04 None None None None N None 0 1.4E-03 None None 0 1E-03 None None None 1E-03 None
T/S 6259 Ig-46 61 rs72648949 0.0745 -1.471 None N 0.106 0.096 0.12205267543 gnomAD-4.0.0 2.74608E-03 None None None None N None 6.13448E-04 2.05034E-03 None 3.36015E-02 0 None 3.75E-04 1.27231E-02 2.33459E-03 1.30652E-03 4.70611E-03
R/G 6352 Ig-47 61 rs569003242 0.1049 -0.91 0.001 N 0.174 0.204 0.303453137403 gnomAD-2.1.1 1.62E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.59E-05 0
R/G 6352 Ig-47 61 rs569003242 0.1049 -0.91 0.001 N 0.174 0.204 0.303453137403 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 7.35E-05 0 0
R/G 6352 Ig-47 61 rs569003242 0.1049 -0.91 0.001 N 0.174 0.204 0.303453137403 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
R/G 6352 Ig-47 61 rs569003242 0.1049 -0.91 0.001 N 0.174 0.204 0.303453137403 gnomAD-4.0.0 8.67894E-06 None None None None N None 0 0 None 0 0 None 0 0 1.18693E-05 0 0
R/K 6352 Ig-47 61 None 0.0731 None 0.001 N 0.123 0.131 0.181679512989 gnomAD-4.0.0 1.59303E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86013E-06 0 0
N/D 6541 Ig-49 61 rs1448829330 0.1023 None 0.007 N 0.217 0.101 0.0884992946249 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
N/D 6541 Ig-49 61 rs1448829330 0.1023 None 0.007 N 0.217 0.101 0.0884992946249 gnomAD-4.0.0 6.57376E-06 None None None None N None 2.41348E-05 0 None 0 0 None 0 0 0 0 0
Y/C 6634 Ig-50 61 rs2079599735 0.2307 None 0.997 N 0.47 0.442 0.685574053984 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
Y/C 6634 Ig-50 61 rs2079599735 0.2307 None 0.997 N 0.47 0.442 0.685574053984 gnomAD-4.0.0 7.10648E-06 None None None None N None 1.74966E-05 0 None 0 0 None 0 0 7.23027E-06 0 0
Y/H 6634 Ig-50 61 rs1211263186 0.213 -0.023 0.028 N 0.239 0.326 0.310147130316 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
Y/H 6634 Ig-50 61 rs1211263186 0.213 -0.023 0.028 N 0.239 0.326 0.310147130316 gnomAD-4.0.0 4.77779E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.30108E-05 0
N/D 6728 Ig-51 62 rs969621252 0.1066 -1.08 0.784 N 0.279 0.139 0.295974979623 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 1.99561E-04 0 None 0 None 0 0 0
N/D 6728 Ig-51 62 rs969621252 0.1066 -1.08 0.784 N 0.279 0.139 0.295974979623 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 2.88018E-04 0 None 0 0 1.47E-05 0 0
N/D 6728 Ig-51 62 rs969621252 0.1066 -1.08 0.784 N 0.279 0.139 0.295974979623 gnomAD-4.0.0 1.11581E-05 None None None None N None 0 0 None 2.70508E-04 0 None 0 0 6.78276E-06 1.09864E-05 1.60174E-05
N/H 6728 Ig-51 62 rs969621252 0.0879 -1.016 0.927 N 0.409 0.228 0.332133492242 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
N/H 6728 Ig-51 62 rs969621252 0.0879 -1.016 0.927 N 0.409 0.228 0.332133492242 gnomAD-4.0.0 4.79108E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39829E-06 0 1.65728E-05
N/K 6728 Ig-51 62 rs745322652 0.2062 None 0.27 N 0.257 0.192 0.203808441222 gnomAD-4.0.0 6.84452E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99735E-07 0 0
L/R 6821 Ig-52 61 None 0.3307 None 1.0 N 0.785 0.32 0.807681222942 gnomAD-4.0.0 1.5925E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86043E-06 0 0
A/E 6915 Ig-53 62 None 0.1414 None 0.012 N 0.393 0.177 0.467585353272 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/S 6915 Ig-53 62 rs201728165 0.0743 -0.754 None N 0.145 0.073 None gnomAD-2.1.1 1.14515E-04 None None None None N None 1.32461E-03 0 None 0 0 None 0 None 0 0 0
A/S 6915 Ig-53 62 rs201728165 0.0743 -0.754 None N 0.145 0.073 None gnomAD-3.1.2 3.74596E-04 None None None None N None 1.35044E-03 6.55E-05 0 0 0 None 0 0 0 0 0
A/S 6915 Ig-53 62 rs201728165 0.0743 -0.754 None N 0.145 0.073 None 1000 genomes 5.99042E-04 None None None None N None 2.3E-03 0 None None 0 0 None None None 0 None
A/S 6915 Ig-53 62 rs201728165 0.0743 -0.754 None N 0.145 0.073 None gnomAD-4.0.0 6.19987E-05 None None None None N None 1.21337E-03 3.33778E-05 None 0 0 None 0 0 0 0 1.12126E-04
L/F 7008 Ig-54 61 rs770243060 0.1059 None 0.81 N 0.389 0.133 0.560341545759 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 1.09649E-03 0 0 None 0 0 0 0 0
L/F 7008 Ig-54 61 rs770243060 0.1059 None 0.81 N 0.389 0.133 0.560341545759 gnomAD-4.0.0 6.57212E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 0
L/I 7008 Ig-54 61 rs770243060 0.0778 -1.242 0.002 N 0.066 0.125 0.435699915968 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.67094E-04 None 0 None 0 0 0
L/I 7008 Ig-54 61 rs770243060 0.0778 -1.242 0.002 N 0.066 0.125 0.435699915968 gnomAD-4.0.0 4.10588E-06 None None None None N None 0 0 None 0 7.5601E-05 None 0 0 2.69875E-06 0 0
N/S 7104 Ig-55 61 rs1684986089 0.0801 None 0.029 N 0.095 0.144 0.124217242631 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.77555E-04
N/S 7104 Ig-55 61 rs1684986089 0.0801 None 0.029 N 0.095 0.144 0.124217242631 gnomAD-4.0.0 6.57091E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 4.77555E-04
F/L 7197 Ig-56 61 rs185823757 0.7079 -1.38 0.454 N 0.329 0.161 0.381580015636 gnomAD-2.1.1 2.15E-05 None None None None N None 0 0 None 0 3.09087E-04 None 0 None 0 0 0
F/L 7197 Ig-56 61 rs185823757 0.7079 -1.38 0.454 N 0.329 0.161 0.381580015636 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 9.65251E-04 None 0 0 0 0 0
F/L 7197 Ig-56 61 rs185823757 0.7079 -1.38 0.454 N 0.329 0.161 0.381580015636 1000 genomes 5.99042E-04 None None None None N None 0 0 None None 3E-03 0 None None None 0 None
F/L 7197 Ig-56 61 rs185823757 0.7079 -1.38 0.454 N 0.329 0.161 0.381580015636 gnomAD-4.0.0 5.57834E-06 None None None None N None 0 0 None 0 2.00956E-04 None 0 0 0 0 0
L/M 7290 Ig-57 61 None 0.1023 None 0.864 N 0.665 0.249 0.534814951121 gnomAD-4.0.0 6.84321E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9956E-07 0 0
N/S 7383 Ig-58 61 rs562295146 0.0637 -0.33 0.003 N 0.093 0.151 0.180583059064 gnomAD-2.1.1 1.07E-05 None None None None N None 4.14E-05 2.84E-05 None 0 0 None 0 None 0 7.84E-06 0
N/S 7383 Ig-58 61 rs562295146 0.0637 -0.33 0.003 N 0.093 0.151 0.180583059064 gnomAD-3.1.2 4.6E-05 None None None None N None 2.41E-05 3.27568E-04 0 0 0 None 0 0 1.47E-05 0 0
N/S 7383 Ig-58 61 rs562295146 0.0637 -0.33 0.003 N 0.093 0.151 0.180583059064 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
N/S 7383 Ig-58 61 rs562295146 0.0637 -0.33 0.003 N 0.093 0.151 0.180583059064 gnomAD-4.0.0 1.02536E-05 None None None None N None 1.68782E-05 8.47831E-05 None 0 0 None 0 0 4.789E-06 0 0
L/P 7575 Ig-60 61 None 0.5963 None 0.999 N 0.719 0.487 0.832360729247 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
L/V 7575 Ig-60 61 rs774759859 0.1222 -1.238 0.597 N 0.515 0.256 0.566774491594 gnomAD-2.1.1 1.43E-05 None None None None N None 0 0 None 0 1.53657E-04 None 0 None 0 7.82E-06 0
L/V 7575 Ig-60 61 rs774759859 0.1222 -1.238 0.597 N 0.515 0.256 0.566774491594 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 3.861E-04 None 0 0 1.47E-05 0 0
L/V 7575 Ig-60 61 rs774759859 0.1222 -1.238 0.597 N 0.515 0.256 0.566774491594 gnomAD-4.0.0 7.68898E-06 None None None None N None 0 0 None 0 9.69838E-05 None 0 0 4.78794E-06 0 0
N/D 7669 Ig-61 62 rs1060500486 0.1201 -1.074 0.302 N 0.239 0.117 0.170165803431 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 0 0
N/D 7669 Ig-61 62 rs1060500486 0.1201 -1.074 0.302 N 0.239 0.117 0.170165803431 gnomAD-4.0.0 4.10675E-06 None None None None N None 0 0 None 0 0 None 0 0 8.9981E-07 4.63929E-05 1.65739E-05
N/S 7669 Ig-61 62 rs781289417 0.064 -0.922 0.006 N 0.077 0.114 0.0954503805726 gnomAD-2.1.1 8.05E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.91E-06 0
N/S 7669 Ig-61 62 rs781289417 0.064 -0.922 0.006 N 0.077 0.114 0.0954503805726 gnomAD-4.0.0 3.42223E-06 None None None None N None 0 2.23654E-05 None 0 2.51978E-05 None 0 0 1.79959E-06 1.15988E-05 0
G/A 7856 Ig-63 62 None 0.0872 None None N 0.089 0.082 0.0297737177859 gnomAD-4.0.0 6.8425E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99522E-07 0 0
G/E 7856 Ig-63 62 rs919783694 0.121 -1.065 0.012 N 0.381 0.042 0.107399877778 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
G/E 7856 Ig-63 62 rs919783694 0.121 -1.065 0.012 N 0.381 0.042 0.107399877778 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/E 7856 Ig-63 62 rs919783694 0.121 -1.065 0.012 N 0.381 0.042 0.107399877778 gnomAD-4.0.0 8.67678E-06 None None None None N None 0 0 None 0 0 None 0 0 1.18674E-05 0 0
G/R 7856 Ig-63 62 None 0.1506 None None N 0.295 0.107 0.165133752707 gnomAD-4.0.0 1.59148E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85878E-06 0 0
P/H 7949 Ig-64 61 None 0.1393 None 0.927 N 0.517 0.295 0.626407189966 gnomAD-4.0.0 1.59141E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85879E-06 0 0
P/S 7949 Ig-64 61 None 0.1014 None 0.425 N 0.43 0.188 0.32714864917 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/G 8045 Ig-65 61 None 0.0801 None 0.042 N 0.244 0.145 0.181679512989 gnomAD-4.0.0 2.05262E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69844E-06 0 0
F/S 8138 Ig-66 61 None 0.1214 None 0.055 N 0.391 0.069 0.464442853059 gnomAD-4.0.0 1.36842E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31868E-05 0
L/P 8231 Ig-67 61 rs373723384 0.1 -0.864 None N 0.29 0.312 None gnomAD-2.1.1 8.05E-06 None None None None N None 1.29166E-04 0 None 0 0 None 0 None 0 0 0
L/P 8231 Ig-67 61 rs373723384 0.1 -0.864 None N 0.29 0.312 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
L/P 8231 Ig-67 61 rs373723384 0.1 -0.864 None N 0.29 0.312 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
L/P 8231 Ig-67 61 rs373723384 0.1 -0.864 None N 0.29 0.312 None gnomAD-4.0.0 2.5618E-06 None None None None N None 3.37519E-05 0 None 0 0 None 0 0 0 0 0
N/K 8324 Ig-68 61 rs879030954 0.3636 None 0.023 N 0.05 0.102 0.126345400529 gnomAD-4.0.0 4.10537E-06 None None None None I None 0 2.23614E-05 None 0 0 None 0 0 4.49757E-06 0 0
L/S 8420 Ig-69 61 None 0.2084 None 0.918 N 0.38 0.196 0.764019764511 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
L/F 8516 Ig-70 61 rs775937094 0.2045 -1.145 0.998 D 0.577 0.222 None gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
L/F 8516 Ig-70 61 rs775937094 0.2045 -1.145 0.998 D 0.577 0.222 None gnomAD-4.0.0 4.95814E-06 None None None None N None 1.33515E-05 0 None 0 0 None 0 0 5.93391E-06 0 0
L/V 8516 Ig-70 61 rs775937094 0.1289 None 0.841 N 0.483 0.217 0.687436468124 gnomAD-4.0.0 4.1058E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49783E-06 0 1.65728E-05
H/P 8610 Ig-71 62 None 0.2771 None 0.065 N 0.47 0.138 0.241078983079 gnomAD-4.0.0 6.84261E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99544E-07 0 0
H/Q 8610 Ig-71 62 rs200939405 0.102 -0.817 0.001 N 0.128 0.061 0.0716867268079 gnomAD-2.1.1 3.21E-05 None None None None N None 3.72178E-04 0 None 0 0 None 0 None 0 0 0
H/Q 8610 Ig-71 62 rs200939405 0.102 -0.817 0.001 N 0.128 0.061 0.0716867268079 gnomAD-3.1.2 5.92E-05 None None None None N None 2.17412E-04 0 0 0 0 None 0 0 0 0 0
H/Q 8610 Ig-71 62 rs200939405 0.102 -0.817 0.001 N 0.128 0.061 0.0716867268079 gnomAD-4.0.0 8.67733E-06 None None None None N None 1.87041E-04 0 None 0 0 None 0 0 0 0 0
H/R 8610 Ig-71 62 rs561059250 0.0702 -1.125 None N 0.101 0.068 0.101711395817 gnomAD-2.1.1 3.57E-05 None None None None N None 0 0 None 0 3.5868E-04 None 0 None 0 0 4.21822E-04
H/R 8610 Ig-71 62 rs561059250 0.0702 -1.125 None N 0.101 0.068 0.101711395817 gnomAD-3.1.2 3.29E-05 None None None None N None 0 6.55E-05 0 0 7.72798E-04 None 0 0 0 0 0
H/R 8610 Ig-71 62 rs561059250 0.0702 -1.125 None N 0.101 0.068 0.101711395817 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
H/R 8610 Ig-71 62 rs561059250 0.0702 -1.125 None N 0.101 0.068 0.101711395817 gnomAD-4.0.0 1.98311E-05 None None None None N None 1.33312E-05 1.66683E-05 None 0 2.00651E-04 None 0 0 5.9339E-06 0 2.24122E-04
L/P 8703 Ig-72 61 None 0.5084 None 1.0 N 0.735 0.551 0.871880940535 gnomAD-4.0.0 1.5915E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85897E-06 0 0
S/A 8797 Ig-73 62 None 0.0686 None None N 0.085 0.115 0.119812018005 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
I/S 8890 Ig-74 61 None 0.1813 None 0.351 N 0.462 0.226 0.692975318687 gnomAD-4.0.0 6.84291E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65717E-05
I/T 8890 Ig-74 61 rs1343627713 0.1501 -1.163 0.351 N 0.41 0.286 0.693843120582 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 8.87E-06 0
I/T 8890 Ig-74 61 rs1343627713 0.1501 -1.163 0.351 N 0.41 0.286 0.693843120582 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 8890 Ig-74 61 rs1343627713 0.1501 -1.163 0.351 N 0.41 0.286 0.693843120582 gnomAD-4.0.0 1.85928E-06 None None None None N None 0 0 None 0 0 None 1.56274E-05 0 1.69534E-06 0 0
F/I 9079 Ig-76 61 None 0.2696 None 0.473 N 0.289 0.122 0.325263233342 gnomAD-4.0.0 1.36844E-06 None None None None N None 0 0 None 0 0 None 0 1.7343E-04 8.9947E-07 0 0
N/H 9265 Ig-78 61 rs397517524 0.0739 -1.006 0.56 N 0.343 0.167 None gnomAD-2.1.1 3.57E-05 None None None None N None 0 0 None 5.79486E-04 0 None 0 None 0 2.34E-05 1.40449E-04
N/H 9265 Ig-78 61 rs397517524 0.0739 -1.006 0.56 N 0.343 0.167 None gnomAD-3.1.2 7.23E-05 None None None None N None 2.41E-05 0 0 2.59366E-03 0 None 0 0 1.47E-05 0 0
N/H 9265 Ig-78 61 rs397517524 0.0739 -1.006 0.56 N 0.343 0.167 None gnomAD-4.0.0 3.16042E-05 None None None None N None 1.33454E-05 0 None 1.21622E-03 0 None 0 0 5.08573E-06 0 1.28094E-04
N/S 9265 Ig-78 61 rs752705285 0.0605 -0.675 None N 0.093 0.078 0.0551355673512 gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
N/S 9265 Ig-78 61 rs752705285 0.0605 -0.675 None N 0.093 0.078 0.0551355673512 gnomAD-4.0.0 8.89489E-06 None None None None N None 0 0 None 0 0 None 0 0 9.89445E-06 0 3.31323E-05
L/V 9457 Ig-80 61 None 0.1156 None 0.001 None 0.266 0.085 0.532168211543 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
R/G 9650 Ig-82 61 None 0.1503 None 0.001 None 0.285 0.152 0.461495907335 gnomAD-4.0.0 1.59115E-06 None None None None N None 0 0 None 0 2.77285E-05 None 0 0 0 0 0
K/E 9961 Ig-84 62 rs745410947 0.3943 -1.344 0.062 None 0.405 0.245 0.260735089382 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 3.29E-05 None 0 0 0
K/E 9961 Ig-84 62 rs745410947 0.3943 -1.344 0.062 None 0.405 0.245 0.260735089382 gnomAD-4.0.0 1.59273E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43571E-05 0
K/N 9961 Ig-84 62 None 0.69 None 0.117 None 0.392 0.135 0.184867976434 gnomAD-4.0.0 7.20193E-06 None None None None N None 0 0 None 0 0 None 0 0 7.87501E-06 0 0
K/R 9961 Ig-84 62 rs778649000 0.0717 -0.929 None None 0.067 0.181 0.149567049428 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.87E-05 None 0 0 0
K/R 9961 Ig-84 62 rs778649000 0.0717 -0.929 None None 0.067 0.181 0.149567049428 gnomAD-4.0.0 5.47539E-06 None None None None N None 0 0 None 0 0 None 0 0 0 9.28936E-05 0
A/T 10048 Ig-85 60 None 0.0981 None 0.27 None 0.357 0.113 0.296329037015 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/N 10137 Ig-86 60 rs2075178264 0.4378 None 0.811 None 0.35 0.215 0.344945010812 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
H/N 10137 Ig-86 60 rs2075178264 0.4378 None 0.811 None 0.35 0.215 0.344945010812 gnomAD-4.0.0 2.56188E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78496E-06 0 0
I/M 13746 Ig-87 63 rs1177814929 0.092 -0.64 0.009 N 0.262 0.111 0.3691244813 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/M 13746 Ig-87 63 rs1177814929 0.092 -0.64 0.009 N 0.262 0.111 0.3691244813 gnomAD-4.0.0 1.59206E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43303E-05 0
I/T 13746 Ig-87 63 None 0.2302 None 0.22 N 0.562 0.325 0.704985832586 gnomAD-4.0.0 2.7375E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7993E-06 1.15953E-05 1.65722E-05
I/V 13746 Ig-87 63 rs554128863 0.1273 -1.18 0.025 N 0.243 0.099 0.496495002422 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/V 13746 Ig-87 63 rs554128863 0.1273 -1.18 0.025 N 0.243 0.099 0.496495002422 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
I/V 13746 Ig-87 63 rs554128863 0.1273 -1.18 0.025 N 0.243 0.099 0.496495002422 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
I/V 13746 Ig-87 63 rs554128863 0.1273 -1.18 0.025 N 0.243 0.099 0.496495002422 gnomAD-4.0.0 6.56978E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07125E-04 0
N/S 13840 Ig-88 61 rs760261561 0.0754 -0.352 0.27 N 0.206 0.094 0.0716867268079 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
N/S 13840 Ig-88 61 rs760261561 0.0754 -0.352 0.27 N 0.206 0.094 0.0716867268079 gnomAD-4.0.0 6.84398E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99649E-06 0 0
N/Y 13840 Ig-88 61 rs763460143 0.1931 -0.376 0.927 N 0.528 0.179 0.243972157842 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/Y 13840 Ig-88 61 rs763460143 0.1931 -0.376 0.927 N 0.528 0.179 0.243972157842 gnomAD-4.0.0 1.5923E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43328E-05 0
H/P 14024 Ig-90 60 None 0.8128 None None N None 0.303 None gnomAD-4.0.0 3.42318E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49898E-06 0 0
H/Q 14024 Ig-90 60 rs1276854895 0.5966 -0.021 None N None 0.083 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.29E-05 None 0 0 0
H/Q 14024 Ig-90 60 rs1276854895 0.5966 -0.021 None N None 0.083 None gnomAD-4.0.0 1.59357E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43633E-05 0
H/R 14024 Ig-90 60 rs2288563 0.3913 -0.49 None N 0.043 0.128 None gnomAD-2.1.1 2.85073E-02 None None None None N None 4.9636E-03 3.32537E-02 None 1.47144E-02 1.01869E-01 None 6.3799E-03 None 4.81085E-02 2.3141E-02 2.74339E-02
H/R 14024 Ig-90 60 rs2288563 0.3913 -0.49 None N 0.043 0.128 None gnomAD-3.1.2 2.15088E-02 None None None None N None 4.60818E-03 2.32009E-02 3.07018E-02 1.90202E-02 9.65557E-02 None 4.51892E-02 6.32911E-03 2.30561E-02 8.06785E-03 2.15517E-02
H/R 14024 Ig-90 60 rs2288563 0.3913 -0.49 None N 0.043 0.128 None 1000 genomes 3.05511E-02 None None None None N None 8E-04 2.74E-02 None None 9.92E-02 2.68E-02 None None None 6.1E-03 None
H/R 14024 Ig-90 60 rs2288563 0.3913 -0.49 None N 0.043 0.128 None gnomAD-4.0.0 2.36264E-02 None None None None N None 4.37602E-03 2.95513E-02 None 1.48749E-02 9.58164E-02 None 4.83407E-02 9.91408E-03 2.20434E-02 6.97362E-03 2.3451E-02
N/I 14112 Ig-91 59 rs749717066 0.5812 0.25 0.056 D 0.481 0.34 0.486494567076 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
N/S 14112 Ig-91 59 rs749717066 0.134 -0.947 0.944 N 0.419 0.329 0.28297238246 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
N/S 14112 Ig-91 59 rs749717066 0.134 -0.947 0.944 N 0.419 0.329 0.28297238246 gnomAD-4.0.0 6.00162E-06 None None None None N None 0 0 None 0 0 None 0 0 6.56252E-06 0 0
K/E 14289 Ig-93 59 rs1387348110 0.2847 0.32 0.989 N 0.558 0.369 0.44898880988 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
K/E 14289 Ig-93 59 rs1387348110 0.2847 0.32 0.989 N 0.558 0.369 0.44898880988 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/E 14289 Ig-93 59 rs1387348110 0.2847 0.32 0.989 N 0.558 0.369 0.44898880988 gnomAD-4.0.0 5.12718E-06 None None None None N None 0 0 None 0 0 None 0 0 9.57584E-06 0 0
H/Q 14378 Ig-94 60 rs2059987336 0.2205 None 0.052 N 0.254 0.052 0.0986583533028 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
H/Q 14378 Ig-94 60 rs2059987336 0.2205 None 0.052 N 0.254 0.052 0.0986583533028 gnomAD-4.0.0 6.57358E-06 None None None None N None 2.4122E-05 0 None 0 0 None 0 0 0 0 0
H/R 14378 Ig-94 60 rs878854307 0.0987 None 0.026 N 0.217 0.106 0.0920862733494 gnomAD-4.0.0 1.59267E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86089E-06 0 0
K/E 14556 Ig-96 60 rs1553738199 0.1547 None 0.201 N 0.445 0.249 0.297031009988 gnomAD-4.0.0 3.21266E-06 None None None None N None 0 2.32396E-05 None 0 0 None 0 0 0 1.45679E-05 0
K/N 14645 Ig-97 60 None 0.6189 None 0.999 N 0.62 0.291 0.361958692863 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/S 14823 Ig-99 59 rs267599051 0.6729 -0.904 1.0 N 0.667 0.368 0.28058544554 gnomAD-2.1.1 4.23E-06 None None None None N None 0 3.18E-05 None 0 0 None 0 None 0 0 0
R/S 14823 Ig-99 59 rs267599051 0.6729 -0.904 1.0 N 0.667 0.368 0.28058544554 gnomAD-4.0.0 1.62536E-06 None None None None N None 0 2.40999E-05 None 0 0 None 0 0 0 0 0
H/P 14912 Ig-100 60 rs2058749191 0.2674 None 0.989 N 0.557 0.34 0.548571244948 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
H/P 14912 Ig-100 60 rs2058749191 0.2674 None 0.989 N 0.557 0.34 0.548571244948 gnomAD-4.0.0 2.0302E-06 None None None None N None 3.49491E-05 0 None 0 0 None 0 0 0 0 0
H/Q 14912 Ig-100 60 rs762830792 0.153 0.438 0.934 N 0.431 0.3 0.12205267543 gnomAD-2.1.1 8.06E-06 None None None None N None 0 5.81E-05 None 0 0 None 0 None 0 0 0
H/Q 14912 Ig-100 60 rs762830792 0.153 0.438 0.934 N 0.431 0.3 0.12205267543 gnomAD-4.0.0 1.36921E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79972E-06 0 0
H/R 14912 Ig-100 60 None 0.0738 None 0.012 N 0.181 0.157 0.302459207581 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
H/Y 14912 Ig-100 60 rs766391823 0.1185 0.98 0.012 N 0.162 0.216 None gnomAD-2.1.1 5.73E-05 None None None None N None 4.14E-05 1.1343E-04 None 3.87147E-04 0 None 0 None 0 5.49E-05 0
H/Y 14912 Ig-100 60 rs766391823 0.1185 0.98 0.012 N 0.162 0.216 None gnomAD-3.1.2 8.55E-05 None None None None N None 2.41E-05 4.59861E-04 0 8.64553E-04 0 None 0 0 2.94E-05 0 0
H/Y 14912 Ig-100 60 rs766391823 0.1185 0.98 0.012 N 0.162 0.216 None gnomAD-4.0.0 5.58088E-05 None None None None N None 1.33608E-05 1.83688E-04 None 5.07237E-04 0 None 0 0 4.91851E-05 0 8.0141E-05
N/H 15001 Ig-101 60 rs373109469 0.108 -0.964 0.004 N 0.117 0.156 None gnomAD-2.1.1 4.44E-05 None None None None N None 0 8.75E-05 None 0 0 None 3.27E-05 None 0 6.24E-05 0
N/H 15001 Ig-101 60 rs373109469 0.108 -0.964 0.004 N 0.117 0.156 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06782E-04 0
N/H 15001 Ig-101 60 rs373109469 0.108 -0.964 0.004 N 0.117 0.156 None gnomAD-4.0.0 3.41181E-05 None None None None N None 0 6.68919E-05 None 0 0 None 0 0 3.22315E-05 6.59196E-05 1.12244E-04
N/K 15001 Ig-101 60 None 0.4072 None 0.379 N 0.288 0.15 0.17258766438 gnomAD-4.0.0 1.36982E-06 None None None None N None 0 0 None 0 0 None 0 1.73913E-04 9.00053E-07 0 0
Q/H 15090 Ig-102 60 None 0.1922 None 0.002 N 0.081 0.24 0.292062946507 gnomAD-4.0.0 6.8468E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15977E-05 0
Q/K 15090 Ig-102 60 rs397517579 0.0881 -0.027 0.01 N 0.105 0.184 0.181679512989 gnomAD-2.1.1 1.25051E-04 None None None None N None 0 0 None 0 0 None 1.01347E-03 None 0 0 0
Q/K 15090 Ig-102 60 rs397517579 0.0881 -0.027 0.01 N 0.105 0.184 0.181679512989 gnomAD-3.1.2 1.98E-05 None None None None N None 0 0 0 0 0 None 0 0 0 6.21633E-04 0
Q/K 15090 Ig-102 60 rs397517579 0.0881 -0.027 0.01 N 0.105 0.184 0.181679512989 gnomAD-4.0.0 6.63619E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.16414E-03 1.60308E-05
K/E 15179 Ig-103 60 rs1559877046 0.4615 None 0.98 N 0.485 0.366 0.354610295913 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
K/E 15179 Ig-103 60 rs1559877046 0.4615 None 0.98 N 0.485 0.366 0.354610295913 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/E 15179 Ig-103 60 rs1559877046 0.4615 None 0.98 N 0.485 0.366 0.354610295913 gnomAD-4.0.0 9.3023E-06 None None None None N None 0 0 None 0 0 None 0 0 1.27198E-05 0 0
K/N 15179 Ig-103 60 rs762005432 0.6787 -1.052 0.4 N 0.221 0.158 0.198526703765 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/N 15179 Ig-103 60 rs762005432 0.6787 -1.052 0.4 N 0.221 0.158 0.198526703765 gnomAD-4.0.0 2.73863E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.64005E-05 0
L/S 15625 Ig-108 58 None 0.0774 None None N 0.22 0.066 0.324161360171 gnomAD-4.0.0 1.59468E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.03251E-05
V/A 16319 Ig-110 58 rs374837771 0.0698 -1.389 None N 0.109 0.135 None gnomAD-2.1.1 1.43E-05 None None None None N None 4.14E-05 0 None 0 0 None 0 None 0 2.35E-05 0
V/A 16319 Ig-110 58 rs374837771 0.0698 -1.389 None N 0.109 0.135 None gnomAD-3.1.2 2.63E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 2.94E-05 0 0
V/A 16319 Ig-110 58 rs374837771 0.0698 -1.389 None N 0.109 0.135 None gnomAD-4.0.0 1.9227E-05 None None None None N None 2.67437E-05 0 None 0 0 None 0 0 2.45936E-05 0 0
P/L 17015 Ig-111 61 None 0.1051 None 0.001 N 0.29 0.162 0.542896531885 gnomAD-4.0.0 1.59324E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86218E-06 0 0
R/L 17337 Ig-112 87 rs775700218 0.2762 0.04 0.983 N 0.485 0.369 0.644543759818 gnomAD-2.1.1 4.19E-06 None None None None N None 0 0 None 0 0 None 3.55E-05 None 0 0 0
R/L 17337 Ig-112 87 rs775700218 0.2762 0.04 0.983 N 0.485 0.369 0.644543759818 gnomAD-4.0.0 2.07002E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.57628E-05 0
R/Q 17337 Ig-112 87 rs775700218 0.1278 -0.351 0.985 N 0.46 0.196 0.353548585375 gnomAD-2.1.1 1.85E-05 None None None None N None 0 0 None 0 5.25E-05 None 0 None 0 3.23E-05 0
R/Q 17337 Ig-112 87 rs775700218 0.1278 -0.351 0.985 N 0.46 0.196 0.353548585375 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 9.42E-05 3.16456E-03 2.94E-05 0 0
R/Q 17337 Ig-112 87 rs775700218 0.1278 -0.351 0.985 N 0.46 0.196 0.353548585375 gnomAD-4.0.0 2.62284E-05 None None None None N None 0 0 None 0 0 None 1.57654E-05 1.665E-04 3.3224E-05 1.12729E-05 0
K/R 17732 Ig-113 56 rs2055177922 0.0974 None 0.946 N 0.433 0.261 0.415690173769 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
K/R 17732 Ig-113 56 rs2055177922 0.0974 None 0.946 N 0.433 0.261 0.415690173769 gnomAD-4.0.0 6.57808E-06 None None None None N None 0 6.5591E-05 None 0 0 None 0 0 0 0 0
P/S 18033 Ig-114 66 rs2054465796 0.1373 None 0.709 N 0.713 0.196 0.368743488249 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
P/S 18033 Ig-114 66 rs2054465796 0.1373 None 0.709 N 0.713 0.196 0.368743488249 gnomAD-4.0.0 6.58172E-06 None None None None N None 2.41464E-05 0 None 0 0 None 0 0 0 0 0
P/A 18447 Ig-115 66 rs2053509362 0.118 None 0.006 N 0.363 0.255 0.260735089382 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
P/A 18447 Ig-115 66 rs2053509362 0.118 None 0.006 N 0.363 0.255 0.260735089382 gnomAD-4.0.0 1.86542E-06 None None None None N None 2.68536E-05 0 None 0 0 None 0 0 0 1.11757E-05 0
P/L 18447 Ig-115 66 rs397517622 0.2 -0.787 0.947 D 0.724 0.394 0.634485840324 gnomAD-2.1.1 2.46E-05 None None None None N None 0 0 None 0 0 None 1.36528E-04 None 0 1.81E-05 0
P/L 18447 Ig-115 66 rs397517622 0.2 -0.787 0.947 D 0.724 0.394 0.634485840324 gnomAD-3.1.2 1.32E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 1.47E-05 0 0
P/L 18447 Ig-115 66 rs397517622 0.2 -0.787 0.947 D 0.724 0.394 0.634485840324 gnomAD-4.0.0 3.29571E-05 None None None None N None 1.34261E-05 0 None 0 2.23874E-05 None 0 1.65399E-04 3.22559E-05 1.34111E-04 0
P/R 18447 Ig-115 66 rs397517622 0.2087 -0.604 0.942 N 0.743 0.436 0.476051820916 gnomAD-2.1.1 8.22E-06 None None None None N None 0 5.95E-05 None 0 0 None 0 None 0 0 0
P/R 18447 Ig-115 66 rs397517622 0.2087 -0.604 0.942 N 0.743 0.436 0.476051820916 gnomAD-4.0.0 2.06011E-06 None None None None N None 0 4.55311E-05 None 0 0 None 0 0 9.00792E-07 0 0
P/S 18447 Ig-115 66 None 0.1421 None 0.477 N 0.591 0.32 0.306053231325 gnomAD-4.0.0 6.8668E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00763E-07 0 0
P/L 18752 Ig-116 65 rs200132226 0.1434 -0.808 0.676 N 0.441 0.19 None gnomAD-2.1.1 1.57529E-04 None None None None N None 4.14E-05 5.68E-05 None 9.7E-05 5.15E-05 None 0 None 4.01E-05 2.82061E-04 2.81928E-04
P/L 18752 Ig-116 65 rs200132226 0.1434 -0.808 0.676 N 0.441 0.19 None gnomAD-3.1.2 1.38192E-04 None None None None N None 2.42E-05 1.31165E-04 0 0 0 None 0 0 2.64815E-04 0 0
P/L 18752 Ig-116 65 rs200132226 0.1434 -0.808 0.676 N 0.441 0.19 None gnomAD-4.0.0 1.99676E-04 None None None None N None 5.34745E-05 6.67601E-05 None 3.38158E-05 0 None 1.56362E-05 1.6469E-04 2.57784E-04 2.19988E-05 8.01025E-05
P/Q 18752 Ig-116 65 rs200132226 0.1442 -1.249 0.008 N 0.162 0.112 0.284539287134 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
P/Q 18752 Ig-116 65 rs200132226 0.1442 -1.249 0.008 N 0.162 0.112 0.284539287134 gnomAD-4.0.0 2.05387E-06 None None None None N None 0 0 None 0 2.5236E-05 None 0 0 8.99841E-07 0 1.65761E-05
K/N 19151 Ig-117 57 rs1362897659 0.7648 0.278 0.982 N 0.506 0.31 0.238096912614 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
K/N 19151 Ig-117 57 rs1362897659 0.7648 0.278 0.982 N 0.506 0.31 0.238096912614 gnomAD-4.0.0 1.59253E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86007E-06 0 0
I/M 19447 Ig-118 57 rs1159324065 0.0718 -1.05 0.001 N 0.371 0.067 0.255270683199 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
I/M 19447 Ig-118 57 rs1159324065 0.0718 -1.05 0.001 N 0.371 0.067 0.255270683199 gnomAD-4.0.0 1.59179E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85905E-06 0 0
I/T 19447 Ig-118 57 None 0.1051 None None N 0.34 0.072 0.222439326576 gnomAD-4.0.0 1.59178E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02517E-05
R/C 19845 Ig-119 56 rs1232069163 0.1391 -0.601 0.047 N 0.399 0.29 0.570337063641 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 6.5189E-04 None 0 None 0 0 0
R/C 19845 Ig-119 56 rs1232069163 0.1391 -0.601 0.047 N 0.399 0.29 0.570337063641 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93949E-04 None 0 0 0 0 0
R/C 19845 Ig-119 56 rs1232069163 0.1391 -0.601 0.047 N 0.399 0.29 0.570337063641 gnomAD-4.0.0 4.95855E-06 None None None None N None 4.00577E-05 0 None 0 2.23174E-05 None 0 0 1.69546E-06 2.19621E-05 0
R/H 19845 Ig-119 56 rs201457934 0.0908 -1.342 0.047 N 0.222 0.166 None gnomAD-2.1.1 1.04721E-04 None None None None N None 0 0 None 0 1.11582E-04 None 3.27E-05 None 4.64E-05 1.96131E-04 0
R/H 19845 Ig-119 56 rs201457934 0.0908 -1.342 0.047 N 0.222 0.166 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 1.9425E-04 None 0 0 4.41E-05 0 0
R/H 19845 Ig-119 56 rs201457934 0.0908 -1.342 0.047 N 0.222 0.166 None gnomAD-4.0.0 4.46261E-05 None None None None N None 0 0 None 0 6.69703E-05 None 6.24805E-05 0 5.00162E-05 1.09806E-05 8.00692E-05
R/L 19845 Ig-119 56 rs201457934 0.1788 0.097 0.608 N 0.409 0.306 0.567930657579 gnomAD-2.1.1 1.21E-05 None None None None N None 0 8.7E-05 None 0 0 None 0 None 0 0 0
R/L 19845 Ig-119 56 rs201457934 0.1788 0.097 0.608 N 0.409 0.306 0.567930657579 gnomAD-4.0.0 2.73727E-06 None None None None N None 0 6.71021E-05 None 0 0 None 0 0 8.99583E-07 0 0
K/R 20139 Ig-120 60 rs1412813943 0.0773 -0.23 0.959 N 0.353 0.215 0.340032825777 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
K/R 20139 Ig-120 60 rs1412813943 0.0773 -0.23 0.959 N 0.353 0.215 0.340032825777 gnomAD-4.0.0 4.7771E-06 None None None None N None 0 0 None 0 0 None 0 0 8.58124E-06 0 0
K/E 20537 Ig-121 59 None 0.3247 None 0.999 N 0.565 0.402 0.391000631824 gnomAD-4.0.0 3.1848E-06 None None None None I None 1.13289E-04 0 None 0 0 None 0 0 0 0 0
P/L 21234 Ig-123 58 None 0.316 None 0.982 N 0.659 0.482 0.58951732002 gnomAD-4.0.0 1.59405E-06 None None None None I None 0 0 None 0 2.79174E-05 None 0 0 0 0 0
P/S 21234 Ig-123 58 rs1335943731 0.211 -1.237 0.885 N 0.509 0.262 0.391156786388 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
P/S 21234 Ig-123 58 rs1335943731 0.211 -1.237 0.885 N 0.509 0.262 0.391156786388 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
P/S 21234 Ig-123 58 rs1335943731 0.211 -1.237 0.885 N 0.509 0.262 0.391156786388 gnomAD-4.0.0 3.04544E-06 None None None None I None 5.24512E-05 0 None 0 0 None 0 0 0 0 0
E/G 22322 Ig-126 58 None 0.2667 None 0.988 N 0.525 0.463 0.443285836454 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
K/N 23008 Ig-128 59 rs2046652524 0.7092 None 1.0 N 0.683 0.336 0.229264304666 gnomAD-3.1.2 6.6E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/N 23008 Ig-128 59 rs2046652524 0.7092 None 1.0 N 0.683 0.336 0.229264304666 gnomAD-4.0.0 1.36874E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79924E-06 0 0
K/T 23008 Ig-128 59 rs765816052 0.3673 -1.117 1.0 N 0.706 0.556 0.565612946506 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
K/T 23008 Ig-128 59 rs765816052 0.3673 -1.117 1.0 N 0.706 0.556 0.565612946506 gnomAD-4.0.0 1.59211E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85976E-06 0 0
P/S 23403 Ig-129 59 rs1399743496 0.187 -0.687 0.955 N 0.529 0.286 0.313818047136 gnomAD-4.0.0 1.59203E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86025E-06 0 0
N/H 23694 Ig-130 58 rs1432742107 0.0803 -0.692 0.896 N 0.417 0.205 0.332902724076 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/H 23694 Ig-130 58 rs1432742107 0.0803 -0.692 0.896 N 0.417 0.205 0.332902724076 gnomAD-4.0.0 1.59204E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43291E-05 0
N/S 23694 Ig-130 58 rs758750534 0.0623 -0.439 0.002 N 0.136 0.083 0.0986583533028 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
N/S 23694 Ig-130 58 rs758750534 0.0623 -0.439 0.002 N 0.136 0.083 0.0986583533028 gnomAD-4.0.0 2.05306E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99578E-07 1.15945E-05 1.65706E-05
K/E 24090 Ig-131 62 rs1709122606 0.4671 None 0.999 N 0.57 0.437 0.426904299391 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
K/R 24776 Ig-133 61 rs530190665 0.0922 -0.093 0.056 N 0.282 0.08 0.311387274539 gnomAD-2.1.1 2.42E-05 None None None None N None 0 0 None 0 2.78738E-04 None 3.27E-05 None 0 0 0
K/R 24776 Ig-133 61 rs530190665 0.0922 -0.093 0.056 N 0.282 0.08 0.311387274539 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.93874E-04 None 0 0 0 0 0
K/R 24776 Ig-133 61 rs530190665 0.0922 -0.093 0.056 N 0.282 0.08 0.311387274539 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
K/R 24776 Ig-133 61 rs530190665 0.0922 -0.093 0.056 N 0.282 0.08 0.311387274539 gnomAD-4.0.0 7.43707E-06 None None None None N None 0 0 None 0 1.33881E-04 None 0 0 0 4.39261E-05 3.20195E-05
K/N 25172 Ig-134 62 None 0.7129 None 0.999 N 0.661 0.292 0.19670166235 gnomAD-4.0.0 1.59193E-06 None None None None N None 0 2.28718E-05 None 0 0 None 0 0 0 0 0
D/E 25569 Ig-135 56 rs1002726225 0.1385 None 0.001 N 0.178 0.055 0.165133752707 gnomAD-4.0.0 2.73767E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59851E-06 0 0
D/H 25569 Ig-135 56 None 0.4407 None 0.879 N 0.479 0.442 0.336400405673 gnomAD-4.0.0 1.5924E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85984E-06 0 0
K/I 26940 Ig-139 61 rs373713790 0.7785 0.743 0.032 N 0.496 0.333 None gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
K/I 26940 Ig-139 61 rs373713790 0.7785 0.743 0.032 N 0.496 0.333 None gnomAD-4.0.0 2.47908E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39074E-06 0 0
D/N 27734 Ig-141 59 None 0.1892 None 0.983 N 0.479 0.339 0.403896168776 gnomAD-4.0.0 1.59171E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85861E-06 0 0
K/R 28023 Ig-142 61 None 0.0791 None 0.698 N 0.491 0.261 0.339793275041 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
K/E 28418 Ig-143 61 None 0.4135 None 0.92 D 0.386 0.323 0.426318900417 gnomAD-4.0.0 1.59151E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85811E-06 0 0
K/N 28418 Ig-143 61 rs759051213 0.7393 -0.884 0.959 D 0.371 0.297 0.215109475489 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/N 28418 Ig-143 61 rs759051213 0.7393 -0.884 0.959 D 0.371 0.297 0.215109475489 gnomAD-4.0.0 1.59154E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
P/L 29900 Ig-147 59 rs1302918553 0.1433 -0.734 0.032 N 0.459 0.229 0.516162830352 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.66E-05 0
P/L 29900 Ig-147 59 rs1302918553 0.1433 -0.734 0.032 N 0.459 0.229 0.516162830352 gnomAD-4.0.0 8.21064E-06 None None None None N None 0 0 None 0 0 None 0 0 9.89388E-06 0 1.6564E-05
P/R 29900 Ig-147 59 None 0.1525 None 0.971 N 0.669 0.281 0.478527412683 gnomAD-4.0.0 6.8422E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15937E-05 0
E/G 30984 Ig-150 58 rs770525487 0.184 -0.091 1.0 N 0.625 0.489 0.673135118597 gnomAD-2.1.1 2.41E-05 None None None None I None 0 1.73802E-04 None 0 0 None 0 None 0 0 0
E/G 30984 Ig-150 58 rs770525487 0.184 -0.091 1.0 N 0.625 0.489 0.673135118597 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/G 30984 Ig-150 58 rs770525487 0.184 -0.091 1.0 N 0.625 0.489 0.673135118597 gnomAD-4.0.0 7.68584E-06 None None None None I None 0 1.01685E-04 None 0 0 None 0 0 0 0 0
E/K 30984 Ig-150 58 rs775878805 0.2213 0.953 0.999 N 0.668 0.458 0.549545986626 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 9.8E-05 None 0 0 0
E/K 30984 Ig-150 58 rs775878805 0.2213 0.953 0.999 N 0.668 0.458 0.549545986626 gnomAD-4.0.0 7.95573E-06 None None None None I None 0 0 None 0 0 None 0 0 0 7.16394E-05 0
K/T 31676 Ig-152 56 None 0.6399 None 1.0 N 0.629 0.584 0.512707719942 gnomAD-4.0.0 1.59123E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85834E-06 0 0
D/E 32073 Ig-153 57 rs1481940319 0.1735 None 0.02 N 0.233 0.074 0.17258766438 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
D/E 32073 Ig-153 57 rs1481940319 0.1735 None 0.02 N 0.233 0.074 0.17258766438 gnomAD-4.0.0 1.5914E-06 None None None None I None 0 0 None 0 2.77285E-05 None 0 0 0 0 0
D/G 32073 Ig-153 57 rs1312027934 0.3371 -0.899 0.969 N 0.515 0.504 0.362160248664 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 4.64E-05 0 0
D/G 32073 Ig-153 57 rs1312027934 0.3371 -0.899 0.969 N 0.515 0.504 0.362160248664 gnomAD-4.0.0 1.59138E-06 None None None None I None 0 0 None 0 0 None 1.88239E-05 0 0 0 0
R/C 32367 Ig-154 61 rs202064385 0.2324 -0.916 1.0 N 0.657 0.476 None gnomAD-2.1.1 4.10723E-04 None None None None N None 0 3.39309E-04 None 9.67305E-04 7.17213E-04 None 1.56853E-03 None 0 2.03347E-04 7.02247E-04
R/C 32367 Ig-154 61 rs202064385 0.2324 -0.916 1.0 N 0.657 0.476 None gnomAD-3.1.2 3.5509E-04 None None None None N None 0 9.82061E-04 0 2.88184E-03 7.73096E-04 None 0 0 2.20549E-04 1.86335E-03 4.79846E-04
R/C 32367 Ig-154 61 rs202064385 0.2324 -0.916 1.0 N 0.657 0.476 None gnomAD-4.0.0 3.01787E-04 None None None None N None 6.66613E-05 4.83221E-04 None 1.79042E-03 8.47155E-04 None 0 1.32013E-03 1.22907E-04 1.99833E-03 4.32207E-04
R/H 32367 Ig-154 61 rs777181557 0.1288 -1.501 1.0 N 0.653 0.407 None gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.35E-05 0
R/H 32367 Ig-154 61 rs777181557 0.1288 -1.501 1.0 N 0.653 0.407 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/H 32367 Ig-154 61 rs777181557 0.1288 -1.501 1.0 N 0.653 0.407 None gnomAD-4.0.0 1.48732E-05 None None None None N None 2.67073E-05 0 None 3.37815E-05 0 None 0 0 1.78E-05 0 0
K/R 32763 Ig-155 56 rs879242471 0.1084 0.045 0.1 N 0.421 0.139 None gnomAD-2.1.1 8.04E-06 None None None None N None 1.29199E-04 0 None 0 0 None 0 None 0 0 0
K/R 32763 Ig-155 56 rs879242471 0.1084 0.045 0.1 N 0.421 0.139 None gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
K/R 32763 Ig-155 56 rs879242471 0.1084 0.045 0.1 N 0.421 0.139 None gnomAD-4.0.0 4.33772E-06 None None None None N None 9.34205E-05 0 None 0 0 None 0 0 0 0 0
M/I 33161 Ig-156 61 rs1190762492 0.1965 None 0.057 N 0.251 0.121 0.516050471323 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
M/I 33161 Ig-156 61 rs1190762492 0.1965 None 0.057 N 0.251 0.121 0.516050471323 gnomAD-4.0.0 1.59134E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8583E-06 0 0
M/T 33161 Ig-156 61 None 0.1672 None 0.165 N 0.33 0.307 0.62009270483 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
M/V 33161 Ig-156 61 rs910034354 0.0863 None 0.056 N 0.183 0.129 0.455996456696 gnomAD-4.0.0 1.59133E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
K/T 33257 Ig-157 55 rs766867347 0.508 -0.602 0.957 N 0.522 0.403 0.381746406553 gnomAD-2.1.1 3.59E-05 None None None None N None 0 0 None 0 5.16369E-04 None 0 None 0 0 0
K/T 33257 Ig-157 55 rs766867347 0.508 -0.602 0.957 N 0.522 0.403 0.381746406553 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92308E-04 None 0 0 0 0 0
K/T 33257 Ig-157 55 rs766867347 0.508 -0.602 0.957 N 0.522 0.403 0.381746406553 gnomAD-4.0.0 6.81976E-06 None None None None N None 0 0 None 0 2.45371E-04 None 0 0 0 0 0
A/P 33558 Ig-158 63 rs376376588 0.5333 None 0.916 N 0.407 0.318 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/P 33558 Ig-158 63 rs376376588 0.5333 None 0.916 N 0.407 0.318 None gnomAD-4.0.0 3.73275E-06 None None None None N None 2.67508E-05 0 None 0 0 None 0 0 3.40277E-06 0 0
A/S 33558 Ig-158 63 rs376376588 0.077 -1.488 0.023 N 0.362 0.045 0.220303561663 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
A/S 33558 Ig-158 63 rs376376588 0.077 -1.488 0.023 N 0.362 0.045 0.220303561663 gnomAD-4.0.0 6.87177E-07 None None None None N None 0 0 None 0 2.52423E-05 None 0 0 0 0 0
P/A 33656 Ig-159 61 rs559295181 0.2128 -1.147 None N 0.119 0.157 0.193865811164 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
P/A 33656 Ig-159 61 rs559295181 0.2128 -1.147 None N 0.119 0.157 0.193865811164 gnomAD-4.0.0 6.84223E-07 None None None None N None 0 0 None 0 2.51902E-05 None 0 0 0 0 0
P/S 33656 Ig-159 61 rs559295181 0.3212 -1.084 None N 0.118 0.148 0.171388866994 gnomAD-2.1.1 2.41E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 3.56E-05 1.65782E-04
P/S 33656 Ig-159 61 rs559295181 0.3212 -1.084 None N 0.118 0.148 0.171388866994 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
P/S 33656 Ig-159 61 rs559295181 0.3212 -1.084 None N 0.118 0.148 0.171388866994 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
P/S 33656 Ig-159 61 rs559295181 0.3212 -1.084 None N 0.118 0.148 0.171388866994 gnomAD-4.0.0 8.05591E-06 None None None None N None 0 3.33289E-05 None 0 0 None 0 0 9.32374E-06 0 0
R/G 34424 Ig-162 62 None 0.6643 None 1.0 N 0.631 0.459 0.37953744168 gnomAD-4.0.0 1.59155E-06 None None None None N None 5.65227E-05 0 None 0 0 None 0 0 0 0 0
R/T 34424 Ig-162 62 rs972117588 0.5745 -0.005 1.0 N 0.674 0.506 0.501940320817 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
R/T 34424 Ig-162 62 rs972117588 0.5745 -0.005 1.0 N 0.674 0.506 0.501940320817 gnomAD-4.0.0 2.05281E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99408E-07 0 3.3129E-05
S/C 35189 Ig-164 61 None 0.1632 None None N 0.245 0.32 0.341934017632 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
N/S 35347 Ig-165 62 rs769505255 0.1093 -1.14 None N 0.089 0.085 0.101711395817 gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 0 None 9.8E-05 None 0 0 0
N/S 35347 Ig-165 62 rs769505255 0.1093 -1.14 None N 0.089 0.085 0.101711395817 gnomAD-4.0.0 4.78895E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99391E-07 6.95604E-05 0
H/D 35480 Ig-166 61 rs1171675957 0.1291 -0.908 0.005 N 0.389 0.184 0.236278675362 gnomAD-2.1.1 4.05E-06 None None None None N None 0 2.95E-05 None 0 0 None 0 None 0 0 0
H/P 35480 Ig-166 61 None 0.1149 None None N 0.154 0.107 0.0762999501168 gnomAD-4.0.0 1.37032E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99876E-07 1.16981E-05 0
H/R 35480 Ig-166 61 rs766337455 0.0603 None None N 0.072 0.088 0.0666544352282 gnomAD-3.1.2 3.94E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 4.41E-05 0 0
H/R 35480 Ig-166 61 rs766337455 0.0603 None None N 0.072 0.088 0.0666544352282 gnomAD-4.0.0 1.61316E-05 None None None None N None 6.68056E-05 1.67949E-05 None 0 0 None 0 0 1.44154E-05 3.32167E-05 0
K/R 35665 Ig-167 59 rs746841189 0.1068 -0.269 0.001 N 0.228 0.085 0.221019684889 gnomAD-2.1.1 7.16E-06 None None None None N None 8.28E-05 0 None 0 0 None 0 None 0 0 0
K/R 35665 Ig-167 59 rs746841189 0.1068 -0.269 0.001 N 0.228 0.085 0.221019684889 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
K/R 35665 Ig-167 59 rs746841189 0.1068 -0.269 0.001 N 0.228 0.085 0.221019684889 gnomAD-4.0.0 5.12888E-06 None None None None N None 6.76361E-05 0 None 0 0 None 0 0 0 0 0
R/L 35762 Ig-168 61 None 0.3276 None 0.068 N 0.255 0.14 0.278143212241 gnomAD-4.0.0 6.84167E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99425E-07 0 0
R/Q 35762 Ig-168 61 rs397517800 0.1033 -0.224 0.01 N 0.095 0.04 0.0666544352282 gnomAD-2.1.1 4.01E-05 None None None None N None 0 2.02852E-04 None 0 0 None 0 None 0 2.66E-05 0
R/Q 35762 Ig-168 61 rs397517800 0.1033 -0.224 0.01 N 0.095 0.04 0.0666544352282 gnomAD-3.1.2 3.29E-05 None None None None N None 0 1.96309E-04 0 0 0 None 0 0 1.47E-05 2.07211E-04 0
R/Q 35762 Ig-168 61 rs397517800 0.1033 -0.224 0.01 N 0.095 0.04 0.0666544352282 gnomAD-4.0.0 3.03636E-05 None None None None N None 0 2.66649E-04 None 0 4.45494E-05 None 0 0 1.69512E-05 8.78387E-05 4.80277E-05
M/T 35959 Ig-169 63 rs1686725786 0.1661 None None N 0.131 0.355 0.572071643794 gnomAD-4.0.0 1.5909E-06 None None None 0.217(OBSL1) -0.344(OBSCN) N None 0 2.28624E-05 None 0 0 None 0 0 0 0 0
M/V 35959 Ig-169 63 rs1220326083 0.1703 None 0.019 N 0.193 0.213 0.464870050199 gnomAD-2.1.1 4.01E-06 None None None -0.147(OBSL1) -0.821(OBSCN) N None 0 0 None 0 0 None 0 None 0 8.85E-06 0
M/V 35959 Ig-169 63 rs1220326083 0.1703 None 0.019 N 0.193 0.213 0.464870050199 gnomAD-4.0.0 3.42075E-06 None None None -0.147(OBSL1) -0.821(OBSCN) N None 0 0 None 0 0 None 0 0 4.49704E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.