Structural position:

  • Domain Type: Ig
  • Aligned Position: 143
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
A/T 69 Ig-1 64 rs1370693255 0.0929 -0.419 0.634 N 0.293 0.157 0.0986583533028 gnomAD-2.1.1 1.77E-05 None None None -0.624(TCAP) N None 4.01E-05 0 None 0 0 None 0 None 0 3.1E-05 0
A/T 69 Ig-1 64 rs1370693255 0.0929 -0.419 0.634 N 0.293 0.157 0.0986583533028 gnomAD-3.1.2 1.97E-05 None None None -0.624(TCAP) N None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 69 Ig-1 64 rs1370693255 0.0929 -0.419 0.634 N 0.293 0.157 0.0986583533028 gnomAD-4.0.0 1.11525E-05 None None None -0.624(TCAP) N None 6.67361E-05 0 None 0 0 None 0 0 1.10169E-05 0 0
E/A 1004 Ig-3 62 rs1413214135 0.937 -0.877 0.999 N 0.63 0.577 0.509820907775 gnomAD-2.1.1 7.97E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
E/A 1004 Ig-3 62 rs1413214135 0.937 -0.877 0.999 N 0.63 0.577 0.509820907775 gnomAD-4.0.0 7.52498E-06 None None None None N None 0 0 None 0 0 None 0 0 9.89242E-06 0 0
E/K 1004 Ig-3 62 rs200902055 0.9446 -0.157 1.0 N 0.608 0.434 None gnomAD-2.1.1 1.23987E-04 None None None None N None 8.01E-05 6.20943E-04 None 0 0 None 0 None 0 6.99E-05 2.77393E-04
E/K 1004 Ig-3 62 rs200902055 0.9446 -0.157 1.0 N 0.608 0.434 None gnomAD-3.1.2 1.3804E-04 None None None None N None 2.1737E-04 3.27225E-04 0 0 0 None 0 0 1.02872E-04 0 0
E/K 1004 Ig-3 62 rs200902055 0.9446 -0.157 1.0 N 0.608 0.434 None gnomAD-4.0.0 6.07216E-05 None None None None N None 1.46902E-04 4.66667E-04 None 0 2.22856E-05 None 0 1.6442E-04 4.66102E-05 0 3.20113E-05
M/T 1145 Ig-4 64 rs1006970338 0.8995 0.629 0.994 N 0.507 0.553 0.659878960944 gnomAD-2.1.1 7.96E-06 None None None None I None 0 0 None 0 5.45E-05 None 0 None 0 8.81E-06 0
M/T 1145 Ig-4 64 rs1006970338 0.8995 0.629 0.994 N 0.507 0.553 0.659878960944 gnomAD-4.0.0 4.7723E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71367E-06 0 3.02206E-05
M/V 1145 Ig-4 64 rs2092731839 0.4755 None 0.985 N 0.463 0.33 0.411001663086 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
M/V 1145 Ig-4 64 rs2092731839 0.4755 None 0.985 N 0.463 0.33 0.411001663086 gnomAD-4.0.0 2.5613E-06 None None None None I None 1.69027E-05 0 None 0 0 None 0 0 2.39197E-06 0 0
V/L 1353 Ig-5 63 rs36062108 0.3095 -0.262 0.008 N 0.244 0.079 0.177238962908 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.85E-06 0
V/L 1353 Ig-5 63 rs36062108 0.3095 -0.262 0.008 N 0.244 0.079 0.177238962908 gnomAD-3.1.2 6.62E-06 None None None None I None 2.44E-05 0 0 0 0 None 0 0 0 0 0
V/L 1353 Ig-5 63 rs36062108 0.3095 -0.262 0.008 N 0.244 0.079 0.177238962908 gnomAD-4.0.0 2.7281E-05 None None None None I None 2.68492E-05 0 None 0 0 None 0 0 3.56049E-05 0 0
P/S 1519 Ig-6 63 None 0.5441 None 1.0 N 0.76 0.43 0.50143340055 gnomAD-4.0.0 1.59121E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85713E-06 0 0
S/A 1619 Ig-7 64 None 0.0688 None 0.91 N 0.443 0.115 0.107399877778 gnomAD-4.0.0 6.00161E-06 None None None None N None 0 0 None 0 0 None 0 0 6.56251E-06 0 0
V/F 1766 Ig-8 64 None 0.3397 None 0.836 N 0.481 0.35 0.846797359206 gnomAD-4.0.0 6.84445E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99303E-07 0 0
V/I 1766 Ig-8 64 rs149494502 0.1084 -0.204 0.021 N 0.326 0.131 None gnomAD-2.1.1 4.97E-05 None None None None N None 2.40385E-04 0 None 0 1.00523E-04 None 6.53E-05 None 0 3.11E-05 0
V/I 1766 Ig-8 64 rs149494502 0.1084 -0.204 0.021 N 0.326 0.131 None gnomAD-3.1.2 4.6E-05 None None None None N None 1.69049E-04 0 0 0 0 None 0 0 0 0 0
V/I 1766 Ig-8 64 rs149494502 0.1084 -0.204 0.021 N 0.326 0.131 None gnomAD-4.0.0 3.53344E-05 None None None None N None 2.40378E-04 0 None 3.37769E-05 1.11443E-04 None 0 0 2.6271E-05 2.19597E-05 0
D/G 1901 Ig-9 61 rs1414147349 0.8415 -0.263 1.0 N 0.66 0.484 0.18995819373 gnomAD-2.1.1 7.97E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.76E-05 0
D/G 1901 Ig-9 61 rs1414147349 0.8415 -0.263 1.0 N 0.66 0.484 0.18995819373 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
D/G 1901 Ig-9 61 rs1414147349 0.8415 -0.263 1.0 N 0.66 0.484 0.18995819373 gnomAD-4.0.0 9.29337E-06 None None None None N None 0 0 None 0 0 None 0 0 1.10169E-05 0 3.20072E-05
D/N 1901 Ig-9 61 None 0.719 None 1.0 N 0.626 0.388 0.149567049428 gnomAD-4.0.0 1.5905E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85657E-06 0 0
D/E 2140 Ig-10 63 rs777009984 0.2284 -0.37 1.0 D 0.46 0.428 0.37568098594 gnomAD-2.1.1 5.67E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.16337E-04 1.38696E-04
D/E 2140 Ig-10 63 rs777009984 0.2284 -0.37 1.0 D 0.46 0.428 0.37568098594 gnomAD-3.1.2 5.91E-05 None None None None N None 0 0 0 0 0 None 0 0 1.32326E-04 0 0
D/E 2140 Ig-10 63 rs777009984 0.2284 -0.37 1.0 D 0.46 0.428 0.37568098594 gnomAD-4.0.0 3.53174E-05 None None None None N None 0 0 None 0 0 None 0 0 4.74578E-05 0 1.60041E-05
T/I 2235 Ig-11 62 rs1381061706 0.1196 None None N 0.178 0.1 0.128392430309 gnomAD-4.0.0 6.8413E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
T/S 2235 Ig-11 62 None 0.0851 None 0.012 N 0.227 0.09 0.0482279557977 gnomAD-4.0.0 6.8413E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99342E-07 0 0
D/G 2327 Ig-12 61 rs1342961134 0.3379 -0.395 1.0 N 0.653 0.539 0.181679512989 gnomAD-2.1.1 7.97E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.76E-05 0
D/G 2327 Ig-12 61 rs1342961134 0.3379 -0.395 1.0 N 0.653 0.539 0.181679512989 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
D/G 2327 Ig-12 61 rs1342961134 0.3379 -0.395 1.0 N 0.653 0.539 0.181679512989 gnomAD-4.0.0 6.19565E-06 None None None None N None 0 0 None 0 0 None 0 0 8.47455E-06 0 0
D/V 2327 Ig-12 61 None 0.5954 None 1.0 N 0.729 0.635 0.488337271218 gnomAD-4.0.0 6.84082E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99313E-07 0 0
D/Y 2327 Ig-12 61 rs1554002409 0.4339 None 1.0 D 0.683 0.637 0.555395099047 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/Y 2327 Ig-12 61 rs1554002409 0.4339 None 1.0 D 0.683 0.637 0.555395099047 gnomAD-4.0.0 2.02994E-06 None None None None N None 1.7474E-05 0 None 0 0 None 0 0 1.20493E-06 0 0
D/G 2416 Ig-13 61 rs780102382 0.2776 -0.254 0.722 D 0.435 0.599 0.393006254552 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.84E-06 0
D/G 2416 Ig-13 61 rs780102382 0.2776 -0.254 0.722 D 0.435 0.599 0.393006254552 gnomAD-4.0.0 2.7363E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59723E-06 0 0
D/N 2416 Ig-13 61 rs1383990376 0.1344 0.216 0.014 N 0.225 0.317 0.261217442401 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 5.44E-05 None 0 None 0 0 0
D/N 2416 Ig-13 61 rs1383990376 0.1344 0.216 0.014 N 0.225 0.317 0.261217442401 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92382E-04 None 0 0 0 0 0
D/N 2416 Ig-13 61 rs1383990376 0.1344 0.216 0.014 N 0.225 0.317 0.261217442401 gnomAD-4.0.0 3.84175E-06 None None None None N None 0 0 None 0 7.27026E-05 None 0 0 0 0 0
R/G 2506 Ig-14 62 rs780415493 0.3904 None 1.0 N 0.636 0.315 0.438064232554 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/G 2506 Ig-14 62 rs780415493 0.3904 None 1.0 N 0.636 0.315 0.438064232554 gnomAD-4.0.0 1.11534E-05 None None None None N None 0 0 None 0 0 None 0 0 1.52546E-05 0 0
R/Q 2506 Ig-14 62 rs758719859 0.1378 0.118 1.0 N 0.737 0.283 0.156986980423 gnomAD-2.1.1 2.83E-05 None None None None N None 1.20183E-04 8.47E-05 None 0 5.03E-05 None 3.27E-05 None 0 0 0
R/Q 2506 Ig-14 62 rs758719859 0.1378 0.118 1.0 N 0.737 0.283 0.156986980423 gnomAD-3.1.2 1.97E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 0 0
R/Q 2506 Ig-14 62 rs758719859 0.1378 0.118 1.0 N 0.737 0.283 0.156986980423 gnomAD-4.0.0 1.05337E-05 None None None None N None 5.33931E-05 8.33861E-05 None 0 4.45772E-05 None 0 0 3.38994E-06 2.19626E-05 0
N/S 2593 Ig-15 61 None 0.1419 None 0.625 N 0.472 0.196 0.165133752707 gnomAD-4.0.0 1.59114E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02261E-05
A/T 2680 Ig-16 60 None 0.0728 None 0.002 N 0.093 0.064 0.0954503805726 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
N/I 2768 Ig-17 62 rs747393998 0.4584 0.193 0.984 D 0.607 0.712 0.902507848322 gnomAD-2.1.1 7.97E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
N/I 2768 Ig-17 62 rs747393998 0.4584 0.193 0.984 D 0.607 0.712 0.902507848322 gnomAD-4.0.0 1.59051E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85646E-06 0 0
N/T 3029 Ig-20 61 rs528892388 0.6731 -0.376 0.999 N 0.673 0.488 0.283371740733 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.8E-06 0
N/T 3029 Ig-20 61 rs528892388 0.6731 -0.376 0.999 N 0.673 0.488 0.283371740733 gnomAD-4.0.0 2.73634E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69788E-06 0 1.65585E-05
S/F 3118 Ig-21 61 rs879133990 0.2271 -0.805 0.939 N 0.518 0.219 0.384252928164 gnomAD-2.1.1 3.18E-05 None None None None N None 1.14837E-04 0 None 0 0 None 0 None 0 0 0
S/F 3118 Ig-21 61 rs879133990 0.2271 -0.805 0.939 N 0.518 0.219 0.384252928164 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/F 3118 Ig-21 61 rs879133990 0.2271 -0.805 0.939 N 0.518 0.219 0.384252928164 gnomAD-4.0.0 3.04477E-06 None None None None N None 1.74752E-05 0 None 0 0 None 0 0 2.40983E-06 0 0
E/D 3209 Ig-22 63 rs1022645763 0.1655 None 0.999 N 0.455 0.145 0.0954503805726 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/D 3209 Ig-22 63 rs1022645763 0.1655 None 0.999 N 0.455 0.145 0.0954503805726 gnomAD-4.0.0 2.47827E-06 None None None None N None 0 0 None 0 0 None 0 0 3.38977E-06 0 0
E/G 3209 Ig-22 63 None 0.4062 None 1.0 N 0.677 0.461 0.250039746154 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
E/A 3300 Ig-23 62 rs1359178318 0.8113 -0.801 0.999 N 0.632 0.662 0.481172606772 gnomAD-2.1.1 7.08E-06 None None None None N None 4.01E-05 0 None 0 0 None 0 None 0 7.76E-06 0
E/A 3300 Ig-23 62 rs1359178318 0.8113 -0.801 0.999 N 0.632 0.662 0.481172606772 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/A 3300 Ig-23 62 rs1359178318 0.8113 -0.801 0.999 N 0.632 0.662 0.481172606772 gnomAD-4.0.0 6.19579E-06 None None None None N None 0 0 None 0 0 None 0 0 8.47448E-06 0 0
E/Q 3300 Ig-23 62 None 0.6844 None 1.0 N 0.619 0.388 0.386882687439 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
E/K 3405 Ig-24 61 rs1187665800 0.1871 -0.17 0.966 N 0.495 0.369 0.478068462777 gnomAD-2.1.1 2.39E-05 None None None None N None 0 5.78E-05 None 0 5.45E-05 None 0 None 0 2.65E-05 0
E/K 3405 Ig-24 61 rs1187665800 0.1871 -0.17 0.966 N 0.495 0.369 0.478068462777 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 4.78927E-04
E/K 3405 Ig-24 61 rs1187665800 0.1871 -0.17 0.966 N 0.495 0.369 0.478068462777 gnomAD-4.0.0 2.10666E-05 None None None None N None 1.33269E-05 3.33322E-05 None 0 2.23025E-05 None 1.56211E-05 1.65071E-04 2.03406E-05 2.19616E-05 3.2002E-05
D/Y 3528 Ig-25 64 None 0.7532 None None None None 0.433 None gnomAD-4.0.0 1.59155E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85897E-06 0 0
N/K 3721 Ig-26 62 rs1216349904 0.1953 None None None None 0.055 None gnomAD-4.0.0 6.842E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
N/S 3721 Ig-26 62 rs2086919348 0.0944 None None None None 0.091 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/S 3721 Ig-26 62 rs2086919348 0.0944 None None None None 0.091 None gnomAD-4.0.0 2.02983E-06 None None None None N None 0 0 None 0 0 None 0 0 2.40991E-06 0 0
D/E 4000 Ig-28 63 None 0.429 None 0.334 N 0.313 0.024 None gnomAD-4.0.0 6.84355E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99431E-07 0 0
D/G 4000 Ig-28 63 rs938144456 0.5012 None 0.201 N 0.289 0.107 None gnomAD-4.0.0 1.59183E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85788E-06 0 0
K/R 4665 Ig-29 60 None 0.0816 None None N 0.243 0.091 0.0401082797425 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/K 4856 Ig-31 62 None 0.2545 None 0.27 N 0.229 0.103 0.0551355673512 gnomAD-4.0.0 1.59115E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85796E-06 0 0
N/S 4856 Ig-31 62 None 0.085 None 0.065 N 0.134 0.122 0.124217242631 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
L/F 4949 Ig-32 62 rs370996177 0.0794 -0.941 0.966 D 0.405 0.298 0.295974979623 gnomAD-2.1.1 3.18E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
L/F 4949 Ig-32 62 rs370996177 0.0794 -0.941 0.966 D 0.405 0.298 0.295974979623 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
L/F 4949 Ig-32 62 rs370996177 0.0794 -0.941 0.966 D 0.405 0.298 0.295974979623 gnomAD-4.0.0 1.97189E-05 None None None None N None 7.24078E-05 0 None 0 0 None 0 0 0 0 0
L/V 4949 Ig-32 62 None 0.065 None 0.012 N 0.215 0.102 0.0806252709748 gnomAD-4.0.0 6.84358E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99533E-07 0 0
D/G 5043 Ig-33 63 rs1578215701 0.1482 None 0.811 N 0.385 0.208 0.208816687407 gnomAD-4.0.0 6.84213E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15945E-05 0
D/V 5043 Ig-33 63 None 0.3062 None 0.984 N 0.518 0.388 0.389283895039 gnomAD-4.0.0 6.84213E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9948E-07 0 0
D/Y 5043 Ig-33 63 rs1345038643 0.2557 -0.136 0.995 N 0.539 0.276 0.401753679984 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 0 9.19118E-04
S/L 5136 Ig-34 62 rs764310312 0.0925 -0.265 0.993 D 0.522 0.493 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/L 5136 Ig-34 62 rs764310312 0.0925 -0.265 0.993 D 0.522 0.493 None gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
S/L 5136 Ig-34 62 rs764310312 0.0925 -0.265 0.993 D 0.522 0.493 None gnomAD-4.0.0 9.29666E-06 None None None None N None 6.67717E-05 1.66728E-05 None 0 0 None 0 0 6.78143E-06 0 1.60118E-05
D/A 5229 Ig-35 62 rs373355675 0.1031 -0.235 0.051 N 0.217 0.167 None gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
D/A 5229 Ig-35 62 rs373355675 0.1031 -0.235 0.051 N 0.217 0.167 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
D/A 5229 Ig-35 62 rs373355675 0.1031 -0.235 0.051 N 0.217 0.167 None gnomAD-4.0.0 3.84297E-06 None None None None N None 5.07288E-05 0 None 0 0 None 0 0 0 0 0
D/H 5229 Ig-35 62 None 0.1598 None 0.966 N 0.351 0.201 0.241664281697 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/L 5322 Ig-36 62 rs758182029 0.1079 0.016 0.896 D 0.502 0.339 0.437527004654 gnomAD-2.1.1 8.05E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 8.9E-06 0
S/L 5322 Ig-36 62 rs758182029 0.1079 0.016 0.896 D 0.502 0.339 0.437527004654 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
S/L 5322 Ig-36 62 rs758182029 0.1079 0.016 0.896 D 0.502 0.339 0.437527004654 gnomAD-4.0.0 2.35488E-05 None None None None I None 0 1.667E-05 None 0 0 None 0 0 3.05142E-05 0 1.60133E-05
R/G 5418 Ig-37 62 rs375436388 0.0766 -0.664 None N 0.106 0.191 None gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
R/G 5418 Ig-37 62 rs375436388 0.0766 -0.664 None N 0.106 0.191 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/G 5418 Ig-37 62 rs375436388 0.0766 -0.664 None N 0.106 0.191 None gnomAD-4.0.0 6.57151E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47033E-05 0 0
R/S 5418 Ig-37 62 rs1252883471 0.1257 None None N 0.179 0.135 0.0716867268079 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/S 5418 Ig-37 62 rs1252883471 0.1257 None None N 0.179 0.135 0.0716867268079 gnomAD-4.0.0 1.30158E-05 None None None None I None 0 0 None 0 0 None 0 0 1.78005E-05 0 0
R/T 5418 Ig-37 62 rs2080809923 0.0938 None 0.012 N 0.243 0.122 0.210429274316 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/T 5418 Ig-37 62 rs2080809923 0.0938 None 0.012 N 0.243 0.122 0.210429274316 gnomAD-4.0.0 6.57203E-06 None None None None I None 2.41359E-05 0 None 0 0 None 0 0 0 0 0
D/N 5605 Ig-39 63 None 0.0721 None 0.001 N 0.275 0.163 0.0884992946249 gnomAD-4.0.0 2.73689E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69848E-06 0 1.65651E-05
K/R 5698 Ig-40 62 None 0.0858 None 0.002 N 0.149 0.081 0.0920862733494 gnomAD-4.0.0 3.18256E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71687E-06 0 0
G/S 5791 Ig-41 62 rs1276489578 0.0791 -0.684 0.01 N 0.105 0.127 0.110078149338 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
G/S 5791 Ig-41 62 rs1276489578 0.0791 -0.684 0.01 N 0.105 0.127 0.110078149338 gnomAD-4.0.0 1.36839E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79892E-06 0 0
Q/P 5980 Ig-43 62 None 0.2993 None 0.065 N 0.331 0.193 0.171388866994 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/C 6167 Ig-45 63 None 0.1371 None 0.002 N 0.466 0.1 0.345859378078 gnomAD-4.0.0 1.59137E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85851E-06 0 0
K/N 6260 Ig-46 62 None 0.1938 None 0.004 N 0.29 0.054 0.0482279557977 gnomAD-4.0.0 1.59169E-06 None None None None N None 0 2.28728E-05 None 0 0 None 0 0 0 0 0
K/Q 6260 Ig-46 62 rs375652574 0.105 -0.147 0.638 N 0.462 0.132 None gnomAD-2.1.1 2.51E-05 None None None None N None 0 2.83E-05 None 0 0 None 0 None 0 4.71E-05 0
K/Q 6260 Ig-46 62 rs375652574 0.105 -0.147 0.638 N 0.462 0.132 None gnomAD-3.1.2 4.6E-05 None None None None N None 0 0 0 0 0 None 0 0 1.0295E-04 0 0
K/Q 6260 Ig-46 62 rs375652574 0.105 -0.147 0.638 N 0.462 0.132 None gnomAD-4.0.0 5.70167E-05 None None None None N None 0 1.6675E-05 None 0 0 None 0 0 7.71422E-05 0 0
S/R 6353 Ig-47 62 None 0.2121 None 0.055 N 0.475 0.07 0.0482279557977 gnomAD-4.0.0 1.36902E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79929E-06 0 0
N/K 6542 Ig-49 62 rs374003118 0.1749 None 0.042 N 0.305 0.111 0.0297737177859 gnomAD-2.1.1 4.04E-06 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 0 0
N/Y 6542 Ig-49 62 rs750316803 0.1304 -0.418 0.602 N 0.478 0.257 0.415820034956 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
N/Y 6542 Ig-49 62 rs750316803 0.1304 -0.418 0.602 N 0.478 0.257 0.415820034956 gnomAD-4.0.0 1.59365E-06 None None None None N None 0 0 None 0 2.77901E-05 None 0 0 0 0 0
N/D 6729 Ig-51 63 rs794729619 0.0724 0.278 0.004 N 0.218 0.048 0.0954503805726 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
N/D 6729 Ig-51 63 rs794729619 0.0724 0.278 0.004 N 0.218 0.048 0.0954503805726 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
N/D 6729 Ig-51 63 rs794729619 0.0724 0.278 0.004 N 0.218 0.048 0.0954503805726 gnomAD-4.0.0 1.85971E-06 None None None None N None 0 5.003E-05 None 0 0 None 0 0 0 0 0
N/H 6729 Ig-51 63 rs794729619 0.0732 None None N 0.187 0.094 0.126345400529 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/H 6729 Ig-51 63 rs794729619 0.0732 None None N 0.187 0.094 0.126345400529 gnomAD-4.0.0 1.23981E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69572E-06 0 0
N/S 6729 Ig-51 63 rs1337506969 0.0682 None None N 0.097 0.08 0.0551355673512 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
N/S 6729 Ig-51 63 rs1337506969 0.0682 None None N 0.097 0.08 0.0551355673512 gnomAD-4.0.0 6.57428E-06 None None None None N None 0 6.55308E-05 None 0 0 None 0 0 0 0 0
N/H 6822 Ig-52 62 None 0.0887 None 0.002 D 0.213 0.276 0.186928172975 gnomAD-4.0.0 6.84645E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16023E-05 0
N/K 6822 Ig-52 62 None 0.2802 None 0.004 N 0.084 0.162 0.162503812791 gnomAD-4.0.0 3.18487E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72069E-06 0 0
N/S 6822 Ig-52 62 rs371518764 0.0699 -0.485 0.001 N 0.093 0.171 None gnomAD-2.1.1 3.57E-05 None None None None N None 8.27E-05 0 None 0 1.02512E-04 None 0 None 0 4.69E-05 0
N/S 6822 Ig-52 62 rs371518764 0.0699 -0.485 0.001 N 0.093 0.171 None gnomAD-3.1.2 7.23E-05 None None None None N None 4.82E-05 6.55E-05 0 0 0 None 0 0 1.1763E-04 0 0
N/S 6822 Ig-52 62 rs371518764 0.0699 -0.485 0.001 N 0.093 0.171 None gnomAD-4.0.0 6.63262E-05 None None None None N None 2.67051E-05 1.66822E-05 None 0 4.45772E-05 None 0 0 8.05415E-05 0 1.12133E-04
N/T 6822 Ig-52 62 rs371518764 0.134 -0.311 0.017 D 0.205 0.19 0.186928172975 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
N/T 6822 Ig-52 62 rs371518764 0.134 -0.311 0.017 D 0.205 0.19 0.186928172975 gnomAD-4.0.0 6.8443E-07 None None None None N None 0 2.23824E-05 None 0 0 None 0 0 0 0 0
K/N 6916 Ig-53 63 None 0.1784 None 0.642 N 0.343 0.1 0.149567049428 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
S/Y 7105 Ig-55 62 None 0.0984 None 0.272 N 0.491 0.176 0.337378238328 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 3.66327E-05
N/K 7291 Ig-57 62 None 0.191 None 0.062 N 0.287 0.083 0.115124310173 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/P 7480 Ig-59 62 rs201065037 0.4233 0.127 0.73 N 0.367 0.394 None gnomAD-2.1.1 1.47131E-04 None None None None N None 8.29E-05 0 None 9.7E-05 0 None 0 None 0 2.99288E-04 0
Q/P 7480 Ig-59 62 rs201065037 0.4233 0.127 0.73 N 0.367 0.394 None gnomAD-3.1.2 1.7092E-04 None None None None N None 1.20662E-04 0 0 0 0 None 0 0 3.08814E-04 0 0
Q/P 7480 Ig-59 62 rs201065037 0.4233 0.127 0.73 N 0.367 0.394 None gnomAD-4.0.0 2.34935E-04 None None None None N None 6.67682E-05 1.6685E-05 None 3.37975E-05 0 None 0 0 3.069E-04 0 1.60215E-04
K/I 7576 Ig-60 62 None 0.804 None 0.43 N 0.683 0.329 0.422762650823 gnomAD-4.0.0 6.84323E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15974E-05 0
E/K 7670 Ig-61 63 None 0.099 None 0.425 N 0.226 0.104 0.134241683229 gnomAD-4.0.0 6.84451E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99789E-07 0 0
N/S 7763 Ig-62 62 None 0.0749 None None N 0.069 0.057 0.0297737177859 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
S/T 7857 Ig-63 63 None 0.0801 None 0.324 N 0.376 0.128 0.0920862733494 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
C/S 7950 Ig-64 62 None 0.0687 None None N 0.079 0.127 0.0482279557977 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/F 8046 Ig-65 62 rs375154651 0.0589 -0.738 None N 0.189 0.022 0.0401082797425 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
L/F 8046 Ig-65 62 rs375154651 0.0589 -0.738 None N 0.189 0.022 0.0401082797425 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/F 8046 Ig-65 62 rs375154651 0.0589 -0.738 None N 0.189 0.022 0.0401082797425 gnomAD-4.0.0 3.71831E-06 None None None None N None 0 0 None 0 0 None 0 0 5.08576E-06 0 0
L/S 8046 Ig-65 62 rs1553904761 0.0585 None None N 0.199 0.035 0.137902524267 gnomAD-4.0.0 1.36842E-06 None None None None N None 0 0 None 0 0 None 0 1.73551E-04 8.9948E-07 0 0
E/Q 8139 Ig-66 62 rs1202623297 0.0989 0.392 0.175 N 0.237 0.091 0.132336055621 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
E/Q 8139 Ig-66 62 rs1202623297 0.0989 0.392 0.175 N 0.237 0.091 0.132336055621 gnomAD-4.0.0 3.42108E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49739E-06 0 0
E/G 8232 Ig-67 62 None 0.122 None 0.027 N 0.375 0.085 0.165133752707 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 6.17284E-04 3.9375E-06 0 0
E/Q 8232 Ig-67 62 None 0.103 None None N 0.272 0.072 0.101711395817 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/E 8325 Ig-68 62 rs72648984 0.161 0.424 0.216 N 0.212 0.194 None gnomAD-2.1.1 5.58292E-03 None None None None I None 1.32253E-03 4.80715E-04 None 2.89967E-04 0 None 0 None 1.51854E-02 8.58054E-03 4.77394E-03
K/E 8325 Ig-68 62 rs72648984 0.161 0.424 0.216 N 0.212 0.194 None gnomAD-3.1.2 4.66442E-03 None None None None I None 1.18158E-03 1.50563E-03 1.09649E-03 2.88018E-04 0 None 1.58133E-02 0 6.82132E-03 2.07039E-04 1.43267E-03
K/E 8325 Ig-68 62 rs72648984 0.161 0.424 0.216 N 0.212 0.194 None 1000 genomes 1.59744E-03 None None None None I None 0 0 None None 0 8E-03 None None None 0 None
K/E 8325 Ig-68 62 rs72648984 0.161 0.424 0.216 N 0.212 0.194 None gnomAD-4.0.0 5.69265E-03 None None None None I None 1.07931E-03 7.49825E-04 None 2.02716E-04 0 None 1.51193E-02 0 6.65662E-03 3.29374E-05 3.68082E-03
K/N 8325 Ig-68 62 rs373995644 0.3215 0.325 0.056 N 0.151 0.103 0.0482279557977 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
K/E 8517 Ig-70 62 None 0.5916 None 0.357 N 0.463 0.093 0.159798565429 gnomAD-4.0.0 1.59173E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85917E-06 0 0
N/K 8611 Ig-71 63 None 0.125 None 0.022 N 0.153 0.08 0.0138822411134 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
N/S 8611 Ig-71 63 rs779262321 0.0629 -0.664 None N 0.111 0.121 0.0138822411134 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.67056E-04 None 0 None 0 0 0
N/S 8611 Ig-71 63 rs779262321 0.0629 -0.664 None N 0.111 0.121 0.0138822411134 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93349E-04 None 0 0 0 0 0
N/S 8611 Ig-71 63 rs779262321 0.0629 -0.664 None N 0.111 0.121 0.0138822411134 gnomAD-4.0.0 2.16925E-05 None None None None N None 0 0 None 0 6.46427E-04 None 0 0 5.08625E-06 0 0
R/K 8798 Ig-73 63 None 0.0684 None None N 0.173 0.052 0.0846915920261 gnomAD-4.0.0 6.84225E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99491E-07 0 0
R/T 8798 Ig-73 63 rs771748059 0.0757 0.116 None N 0.177 0.093 0.136095386433 gnomAD-2.1.1 3.22E-05 None None None None N None 0 8.7E-05 None 0 0 None 0 None 0 3.57E-05 1.65948E-04
R/T 8798 Ig-73 63 rs771748059 0.0757 0.116 None N 0.177 0.093 0.136095386433 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/T 8798 Ig-73 63 rs771748059 0.0757 0.116 None N 0.177 0.093 0.136095386433 gnomAD-4.0.0 3.03658E-05 None None None None N None 1.33511E-05 6.66844E-05 None 0 0 None 0 0 3.47529E-05 0 4.80292E-05
N/H 8891 Ig-74 62 None 0.0841 None 0.295 N 0.271 0.151 0.181679512989 gnomAD-4.0.0 1.59163E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43316E-05 0
N/K 8891 Ig-74 62 None 0.1895 None 0.012 N 0.187 0.145 0.0297737177859 gnomAD-4.0.0 6.84285E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99535E-07 0 0
N/S 8891 Ig-74 62 rs146057575 0.0699 -0.235 None N 0.077 0.089 None gnomAD-2.1.1 3.46196E-04 None None None None N None 2.89304E-04 7.36836E-04 None 3.86623E-04 0 None 4.90773E-04 None 0 2.96426E-04 9.83422E-04
N/S 8891 Ig-74 62 rs146057575 0.0699 -0.235 None N 0.077 0.089 None gnomAD-3.1.2 3.28528E-04 None None None None N None 1.44711E-04 1.17863E-03 0 0 0 None 0 1.58228E-02 2.35177E-04 2.07039E-04 1.91205E-03
N/S 8891 Ig-74 62 rs146057575 0.0699 -0.235 None N 0.077 0.089 None 1000 genomes 1.59744E-03 None None None None N None 5.3E-03 0 None None 0 1E-03 None None None 0 None
N/S 8891 Ig-74 62 rs146057575 0.0699 -0.235 None N 0.077 0.089 None gnomAD-4.0.0 2.62133E-04 None None None None N None 3.59789E-04 7.66794E-04 None 2.36486E-04 0 None 0 1.45167E-02 1.57667E-04 4.17298E-04 4.96254E-04
M/I 8987 Ig-75 62 None 0.1297 None None N 0.063 0.176 0.134241683229 gnomAD-4.0.0 1.59138E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85838E-06 0 0
M/L 8987 Ig-75 62 None 0.079 None None N 0.128 0.041 0.199424873507 gnomAD-4.0.0 6.84227E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99478E-07 0 0
M/T 8987 Ig-75 62 None 0.0751 None None N 0.084 0.142 0.332646915603 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
D/E 9080 Ig-76 62 rs1418163017 0.1238 None None N 0.144 0.049 0.0716867268079 gnomAD-4.0.0 6.84218E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99467E-07 0 0
D/N 9080 Ig-76 62 rs1405635875 0.0751 -0.376 None N 0.101 0.109 0.104622674875 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/N 9080 Ig-76 62 rs1405635875 0.0751 -0.376 None N 0.101 0.109 0.104622674875 gnomAD-4.0.0 4.10535E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49738E-06 0 1.65667E-05
S/G 9173 Ig-77 62 rs1312859517 0.0748 -0.859 0.454 N 0.334 0.08 0.158396225186 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
S/G 9173 Ig-77 62 rs1312859517 0.0748 -0.859 0.454 N 0.334 0.08 0.158396225186 gnomAD-4.0.0 1.84731E-05 None None None None N None 0 0 None 0 0 None 0 0 2.33855E-05 0 1.6564E-05
S/N 9173 Ig-77 62 None 0.0748 None 0.002 N 0.107 0.076 0.101711395817 gnomAD-4.0.0 1.59116E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85799E-06 0 0
Q/H 9266 Ig-78 62 rs543197876 0.1643 None 0.996 N 0.329 0.185 0.132336055621 gnomAD-4.0.0 4.78964E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29647E-06 0 0
Q/L 9266 Ig-78 62 None 0.168 None 0.959 N 0.391 0.257 0.415947407303 gnomAD-4.0.0 1.59135E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02425E-05
K/E 9362 Ig-79 62 rs774589686 0.1425 0.461 0.027 None 0.38 0.053 0.12205267543 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
K/E 9362 Ig-79 62 rs774589686 0.1425 0.461 0.027 None 0.38 0.053 0.12205267543 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/E 9362 Ig-79 62 rs774589686 0.1425 0.461 0.027 None 0.38 0.053 0.12205267543 gnomAD-4.0.0 8.11935E-06 None None None None N None 0 0 None 0 0 None 0 0 9.63927E-06 0 0
K/T 9555 Ig-81 63 rs760060633 0.1349 -0.028 0.001 None 0.193 0.076 0.12205267543 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/T 9555 Ig-81 63 rs760060633 0.1349 -0.028 0.001 None 0.193 0.076 0.12205267543 gnomAD-4.0.0 1.59112E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
D/E 9651 Ig-82 62 None 0.1291 None None None 0.087 0.049 0.0482279557977 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
D/N 9651 Ig-82 62 None 0.0904 None None None 0.109 0.088 0.0666544352282 gnomAD-4.0.0 2.73677E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59774E-06 0 0
D/H 9760 Ig-83 63 rs372537023 0.8184 -0.698 1.0 None 0.419 0.386 None gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.65E-05 0
D/H 9760 Ig-83 63 rs372537023 0.8184 -0.698 1.0 None 0.419 0.386 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/H 9760 Ig-83 63 rs372537023 0.8184 -0.698 1.0 None 0.419 0.386 None gnomAD-4.0.0 1.05344E-05 None None None None N None 0 0 None 0 0 None 0 0 1.44086E-05 0 0
D/N 9760 Ig-83 63 rs372537023 0.2584 0.221 0.989 None 0.43 0.309 0.305410167561 gnomAD-2.1.1 8.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
D/N 9760 Ig-83 63 rs372537023 0.2584 0.221 0.989 None 0.43 0.309 0.305410167561 gnomAD-4.0.0 8.20987E-06 None None None None N None 0 0 None 0 0 None 0 0 9.8936E-06 0 1.65634E-05
D/Y 9760 Ig-83 63 None 0.662 None 0.999 None 0.623 0.413 0.273503213844 gnomAD-4.0.0 8.89402E-06 None None None None N None 0 0 None 0 0 None 0 0 1.16924E-05 0 0
N/S 9962 Ig-84 63 None 0.2175 None 0.002 None 0.1 0.128 0.162503812791 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
D/G 10049 Ig-85 61 rs2075487390 0.6616 None 0.919 None 0.595 0.298 0.18274738541 gnomAD-4.0.0 2.05243E-06 None None None None N None 2.98686E-05 0 None 0 0 None 0 0 1.7988E-06 0 0
N/D 10138 Ig-86 61 None 0.4433 None 0.434 None 0.283 0.202 0.0920862733494 gnomAD-4.0.0 2.05243E-06 None None None None N None 0 0 None 0 2.51902E-05 None 0 0 0 1.15931E-05 1.6564E-05
N/H 10138 Ig-86 61 rs539637860 0.3808 -0.833 1.0 None 0.663 0.385 0.143124449307 gnomAD-2.1.1 4.01E-05 None None None None N None 0 0 None 0 1.66889E-04 None 2.28758E-04 None 0 0 0
N/H 10138 Ig-86 61 rs539637860 0.3808 -0.833 1.0 None 0.663 0.385 0.143124449307 gnomAD-3.1.2 4.6E-05 None None None None N None 0 6.55E-05 0 0 3.8432E-04 None 0 0 0 8.28157E-04 0
N/H 10138 Ig-86 61 rs539637860 0.3808 -0.833 1.0 None 0.663 0.385 0.143124449307 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
N/H 10138 Ig-86 61 rs539637860 0.3808 -0.833 1.0 None 0.663 0.385 0.143124449307 gnomAD-4.0.0 2.04471E-05 None None None None N None 0 1.66644E-05 None 0 1.11383E-04 None 0 0 0 2.85451E-04 1.60051E-05
N/S 10138 Ig-86 61 None 0.2759 None 0.996 None 0.4 0.399 0.15556083564 gnomAD-4.0.0 1.5909E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
D/N 13841 Ig-88 62 rs201257644 0.1315 0.121 0.612 N 0.197 0.144 None gnomAD-2.1.1 3.46922E-04 None None None None N None 2.48201E-04 1.13186E-04 None 0 0 None 0 None 0 6.81231E-04 0
D/N 13841 Ig-88 62 rs201257644 0.1315 0.121 0.612 N 0.197 0.144 None gnomAD-3.1.2 4.07793E-04 None None None None N None 2.89631E-04 2.62295E-04 0 0 0 None 0 0 6.76709E-04 0 0
D/N 13841 Ig-88 62 rs201257644 0.1315 0.121 0.612 N 0.197 0.144 None 1000 genomes 3.99361E-04 None None None None N None 8E-04 0 None None 0 1E-03 None None None 0 None
D/N 13841 Ig-88 62 rs201257644 0.1315 0.121 0.612 N 0.197 0.144 None gnomAD-4.0.0 6.366E-04 None None None None N None 1.86682E-04 1.00037E-04 None 0 0 None 0 0 8.32562E-04 0 4.00269E-04
D/Y 13841 Ig-88 62 None 0.4109 None 1.0 N 0.621 0.269 0.347659731818 gnomAD-4.0.0 6.84415E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99666E-07 0 0
N/H 13936 Ig-89 61 None 0.336 None 1.0 D 0.567 0.346 0.223847106136 gnomAD-4.0.0 2.07122E-06 None None None None N None 0 0 None 0 0 None 0 0 2.71602E-06 0 0
K/E 14025 Ig-90 61 rs762241231 0.3943 0.492 0.012 N 0.444 0.125 0.148003135375 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
K/E 14025 Ig-90 61 rs762241231 0.3943 0.492 0.012 N 0.444 0.125 0.148003135375 gnomAD-4.0.0 6.84613E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99787E-06 0 0
K/R 14025 Ig-90 61 None 0.115 None 0.058 N 0.463 0.135 0.193865811164 gnomAD-4.0.0 1.59342E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43612E-05 0
D/E 14113 Ig-91 60 None 0.2756 None 0.012 N 0.277 0.069 0.101711395817 gnomAD-4.0.0 1.59261E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86046E-06 0 0
E/G 14202 Ig-92 61 rs765485610 0.2004 -0.346 0.978 N 0.52 0.4 0.282575091529 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
E/G 14202 Ig-92 61 rs765485610 0.2004 -0.346 0.978 N 0.52 0.4 0.282575091529 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/G 14202 Ig-92 61 rs765485610 0.2004 -0.346 0.978 N 0.52 0.4 0.282575091529 gnomAD-4.0.0 5.1265E-06 None None None None N None 6.76796E-05 0 None 0 0 None 0 0 0 0 0
D/A 14557 Ig-96 61 None 0.2496 None 0.22 D 0.499 0.526 0.477917065107 gnomAD-4.0.0 1.60684E-06 None None None None N None 0 0 None 0 0 None 1.89408E-05 0 0 0 0
D/N 14557 Ig-96 61 rs794729431 0.0832 None None N 0.145 0.259 0.298056030225 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 14557 Ig-96 61 rs794729431 0.0832 None None N 0.145 0.259 0.298056030225 gnomAD-4.0.0 1.5495E-05 None None None None N None 1.69474E-05 0 None 0 0 None 1.57679E-05 0 2.40981E-05 0 0
D/Y 14557 Ig-96 61 None 0.1724 None 0.859 D 0.579 0.63 0.474010150167 gnomAD-4.0.0 1.60671E-06 None None None None N None 0 0 None 0 0 None 0 0 2.88203E-06 0 0
N/D 14735 Ig-98 61 None 0.1878 None 0.997 N 0.607 0.385 0.260249123532 gnomAD-4.0.0 1.59319E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86113E-06 0 0
N/K 14735 Ig-98 61 rs773518259 0.4023 0.046 0.999 N 0.685 0.279 0.203808441222 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
N/K 14735 Ig-98 61 rs773518259 0.4023 0.046 0.999 N 0.685 0.279 0.203808441222 gnomAD-4.0.0 3.18619E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72207E-06 0 0
N/S 14735 Ig-98 61 rs763464756 0.119 -0.333 0.997 N 0.564 0.357 0.246215685461 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
N/S 14735 Ig-98 61 rs763464756 0.119 -0.333 0.997 N 0.564 0.357 0.246215685461 gnomAD-4.0.0 4.79188E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29826E-06 0 0
D/H 14824 Ig-99 60 None 0.4292 None 0.994 N 0.737 0.236 0.251639045875 gnomAD-4.0.0 6.90164E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.19136E-05 0
D/N 14824 Ig-99 60 rs781775537 0.1004 -0.008 0.085 N 0.383 0.105 0.162503812791 gnomAD-2.1.1 4.21E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.17E-06 0
D/N 14824 Ig-99 60 rs781775537 0.1004 -0.008 0.085 N 0.383 0.105 0.162503812791 gnomAD-4.0.0 1.38033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80731E-06 0 0
D/V 14824 Ig-99 60 rs1165288151 0.4912 None 0.989 N 0.757 0.494 0.409937222855 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/V 14824 Ig-99 60 rs1165288151 0.4912 None 0.989 N 0.757 0.494 0.409937222855 gnomAD-4.0.0 3.12266E-06 None None None None N None 0 0 None 0 0 None 0 0 4.25624E-06 0 0
D/Y 14824 Ig-99 60 None 0.297 None 0.999 D 0.769 0.288 0.407082143382 gnomAD-4.0.0 2.76066E-06 None None None None N None 0 0 None 0 0 None 0 0 3.61462E-06 0 0
D/G 14913 Ig-100 61 None 0.078 None None N 0.125 0.069 0.0138822411134 gnomAD-4.0.0 6.16141E-06 None None None None N None 0 0 None 0 0 None 0 0 8.09877E-06 0 0
D/N 14913 Ig-100 61 None 0.0964 None None N 0.243 0.128 0.0482279557977 gnomAD-4.0.0 3.18682E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72452E-06 0 0
K/Q 15002 Ig-101 61 rs1450027251 0.3071 0.333 1.0 N 0.736 0.367 0.166414681773 gnomAD-4.0.0 1.59496E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86405E-06 0 0
K/R 15002 Ig-101 61 None 0.1002 None 0.999 N 0.619 0.296 0.222439326576 gnomAD-4.0.0 2.7396E-06 None None None None N None 0 0 None 0 0 None 0 0 3.60017E-06 0 0
K/T 15002 Ig-101 61 rs1201766795 0.5674 0.046 1.0 N 0.691 0.519 0.371157983038 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/T 15002 Ig-101 61 rs1201766795 0.5674 0.046 1.0 N 0.691 0.519 0.371157983038 gnomAD-4.0.0 6.849E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16034E-05 0
N/D 15091 Ig-102 61 rs776532148 0.1111 -0.706 0.005 N 0.095 0.323 0.276065633971 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.62E-05 None 0 None 0 0 0
N/D 15091 Ig-102 61 rs776532148 0.1111 -0.706 0.005 N 0.095 0.323 0.276065633971 gnomAD-4.0.0 2.7387E-06 None None None None N None 0 0 None 0 1.01133E-04 None 0 0 0 0 0
N/Y 15091 Ig-102 61 rs776532148 0.1995 -0.295 0.989 D 0.463 0.623 0.769302405176 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 1.3077E-04 None 0 0 0
N/Y 15091 Ig-102 61 rs776532148 0.1995 -0.295 0.989 D 0.463 0.623 0.769302405176 gnomAD-4.0.0 1.16395E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.97156E-04 0
D/Y 15180 Ig-103 61 None 0.2537 None 0.989 N 0.435 0.291 0.264081493735 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/G 15268 Ig-104 61 rs2058150967 0.151 None None N 0.235 0.159 0.154104182512 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/H 15268 Ig-104 61 None 0.2983 None 0.317 N 0.372 0.108 0.126345400529 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
D/E 15362 Ig-105 61 rs2058092096 0.3039 None 0.17 N 0.316 0.06 0.0920862733494 gnomAD-4.0.0 1.59442E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86443E-06 0 0
D/G 15362 Ig-105 61 rs779619831 0.3075 -0.39 0.885 N 0.535 0.292 0.144782658237 gnomAD-4.0.0 1.59441E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43451E-05 0
D/Y 15451 Ig-106 61 rs1576541228 0.4266 None 0.999 D 0.675 0.665 0.891608219599 gnomAD-4.0.0 4.10974E-06 None None None None N None 0 0 None 0 0 None 0 0 5.40103E-06 0 0
D/G 15540 Ig-107 61 rs1184454225 0.2294 None 0.124 N 0.481 0.465 0.339555952218 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/G 15540 Ig-107 61 rs1184454225 0.2294 None 0.124 N 0.481 0.465 0.339555952218 gnomAD-4.0.0 2.567E-06 None None None None N None 0 0 None 0 0 None 0 0 4.79609E-06 0 0
E/G 15626 Ig-108 59 rs753479822 0.1709 -0.283 0.22 N 0.493 0.088 0.239305524855 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
E/G 15626 Ig-108 59 rs753479822 0.1709 -0.283 0.22 N 0.493 0.088 0.239305524855 gnomAD-4.0.0 1.59455E-06 None None None None N None 0 2.292E-05 None 0 0 None 0 0 0 0 0
P/A 16024 Ig-109 57 rs750357667 0.2571 -0.539 1.0 N 0.689 0.307 0.184867976434 gnomAD-2.1.1 8.08E-06 None None None None N None 1.29383E-04 0 None 0 0 None 0 None 0 0 0
P/A 16024 Ig-109 57 rs750357667 0.2571 -0.539 1.0 N 0.689 0.307 0.184867976434 gnomAD-3.1.2 3.29E-05 None None None None N None 1.20825E-04 0 0 0 0 None 0 0 0 0 0
P/A 16024 Ig-109 57 rs750357667 0.2571 -0.539 1.0 N 0.689 0.307 0.184867976434 gnomAD-4.0.0 5.58132E-06 None None None None N None 1.06983E-04 0 None 0 0 None 0 0 0 0 1.60267E-05
P/L 16024 Ig-109 57 None 0.4305 None 1.0 N 0.773 0.464 0.584336440749 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
P/S 16024 Ig-109 57 rs750357667 0.3053 -0.337 1.0 N 0.751 0.332 0.154104182512 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
P/S 16024 Ig-109 57 rs750357667 0.3053 -0.337 1.0 N 0.751 0.332 0.154104182512 gnomAD-4.0.0 2.73843E-05 None None None None N None 0 0 None 0 0 None 0 0 3.59944E-05 0 0
D/H 17338 Ig-112 88 None 0.5847 None 1.0 N 0.753 0.359 0.20549828249 gnomAD-4.0.0 1.62489E-06 None None None None N None 0 0 None 0 0 None 0 0 2.9099E-06 0 0
D/E 17733 Ig-113 57 None 0.1611 None None N 0.146 0.098 0.101711395817 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
K/R 18034 Ig-114 67 rs747897792 0.0828 0.299 0.642 N 0.277 0.12 0.178374595973 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 0 0
K/R 18034 Ig-114 67 rs747897792 0.0828 0.299 0.642 N 0.277 0.12 0.178374595973 gnomAD-4.0.0 6.3743E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.73691E-05 0
E/A 18448 Ig-115 67 rs1297622212 0.1086 -0.442 0.09 N 0.341 0.086 0.203808441222 gnomAD-2.1.1 4.11E-06 None None None None N None 6.51E-05 0 None 0 0 None 0 None 0 0 0
E/A 18448 Ig-115 67 rs1297622212 0.1086 -0.442 0.09 N 0.341 0.086 0.203808441222 gnomAD-4.0.0 1.37305E-06 None None None None N None 3.01896E-05 0 None 0 0 None 0 0 9.00679E-07 0 0
Q/E 18753 Ig-116 66 None 0.0722 None 0.4 N 0.199 0.158 0.119812018005 gnomAD-4.0.0 1.59342E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43592E-05 0
Q/R 18753 Ig-116 66 None 0.1114 None 0.98 N 0.491 0.27 0.154104182512 gnomAD-4.0.0 1.59343E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43625E-05 0
K/E 19448 Ig-118 58 rs900082928 0.1597 0.204 0.999 N 0.639 0.344 0.235664433957 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/E 19448 Ig-118 58 rs900082928 0.1597 0.204 0.999 N 0.639 0.344 0.235664433957 gnomAD-3.1.2 1.97E-05 None None None None N None 0 1.31062E-04 0 0 0 None 0 0 0 0 4.78469E-04
K/E 19448 Ig-118 58 rs900082928 0.1597 0.204 0.999 N 0.639 0.344 0.235664433957 gnomAD-4.0.0 5.57817E-06 None None None None N None 0 5.00384E-05 None 0 0 None 0 0 4.23855E-06 0 1.60143E-05
K/R 19448 Ig-118 58 rs2050867556 0.0912 None 0.999 N 0.594 0.196 0.176091768786 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/R 19448 Ig-118 58 rs2050867556 0.0912 None 0.999 N 0.594 0.196 0.176091768786 gnomAD-4.0.0 1.85939E-06 None None None None N None 0 3.33589E-05 None 0 0 None 0 0 8.47711E-07 0 0
N/H 19846 Ig-119 57 rs749738999 0.1233 -0.614 0.976 N 0.339 0.252 0.194818534648 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
N/H 19846 Ig-119 57 rs749738999 0.1233 -0.614 0.976 N 0.339 0.252 0.194818534648 gnomAD-4.0.0 3.18366E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71873E-06 0 0
N/S 20140 Ig-120 61 rs1187229401 0.1217 -0.425 0.01 N 0.105 0.111 None gnomAD-2.1.1 7.15E-06 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 0 0
N/S 20140 Ig-120 61 rs1187229401 0.1217 -0.425 0.01 N 0.105 0.111 None gnomAD-3.1.2 1.32E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
N/S 20140 Ig-120 61 rs1187229401 0.1217 -0.425 0.01 N 0.105 0.111 None gnomAD-4.0.0 3.84579E-06 None None None None N None 5.07528E-05 0 None 0 0 None 0 0 0 0 0
N/T 20140 Ig-120 61 None 0.2078 None 0.27 N 0.187 0.17 0.181679512989 gnomAD-4.0.0 1.59237E-06 None None None None N None 0 0 None 0 2.77331E-05 None 0 0 0 0 0
N/Y 20140 Ig-120 61 rs879086626 0.1977 None 0.975 N 0.391 0.294 None gnomAD-4.0.0 1.43726E-05 None None None None N None 0 0 None 0 0 None 0 0 1.88934E-05 0 0
N/D 21235 Ig-123 59 rs786205305 0.1152 -0.074 None N 0.13 0.075 0.158396225186 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/D 21235 Ig-123 59 rs786205305 0.1152 -0.074 None N 0.13 0.075 0.158396225186 gnomAD-4.0.0 1.59381E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43361E-05 0
N/S 21235 Ig-123 59 rs751607765 0.0763 -0.097 0.042 N 0.356 0.159 0.15556083564 gnomAD-2.1.1 2.15E-05 None None None None N None 0 0 None 0 0 None 1.30933E-04 None 0 1.57E-05 0
N/S 21235 Ig-123 59 rs751607765 0.0763 -0.097 0.042 N 0.356 0.159 0.15556083564 gnomAD-3.1.2 3.95E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 6.20604E-04 0
N/S 21235 Ig-123 59 rs751607765 0.0763 -0.097 0.042 N 0.356 0.159 0.15556083564 gnomAD-4.0.0 2.10844E-05 None None None None N None 0 0 None 0 2.24185E-05 None 0 1.64853E-04 4.23955E-06 2.85576E-04 1.60246E-05
D/N 21528 Ig-124 60 rs2048653243 0.148 None 0.733 N 0.263 0.234 0.107399877778 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 21528 Ig-124 60 rs2048653243 0.148 None 0.733 N 0.263 0.234 0.107399877778 gnomAD-4.0.0 5.12722E-06 None None None None N None 0 0 None 0 0 None 0 0 9.57887E-06 0 0
S/R 21925 Ig-125 60 rs72646867 0.7189 -0.112 0.982 N 0.435 0.248 0.0551355673512 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9E-06 0
S/R 21925 Ig-125 60 rs72646867 0.7189 -0.112 0.982 N 0.435 0.248 0.0551355673512 gnomAD-4.0.0 6.86384E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01486E-07 0 0
N/I 22323 Ig-126 59 None 0.3771 None None N 0.335 0.302 0.414930877219 gnomAD-4.0.0 1.20036E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31254E-06 0 0
D/G 22612 Ig-127 53 None 0.2365 None 1.0 N 0.695 0.478 0.28492961333 gnomAD-4.0.0 1.59178E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8594E-06 0 0
D/N 22612 Ig-127 53 rs757888367 0.1288 -0.601 1.0 N 0.643 0.364 0.235664433957 gnomAD-2.1.1 1.21E-05 None None None None N None 0 2.9E-05 None 0 0 None 6.54E-05 None 0 0 0
D/N 22612 Ig-127 53 rs757888367 0.1288 -0.601 1.0 N 0.643 0.364 0.235664433957 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
D/N 22612 Ig-127 53 rs757888367 0.1288 -0.601 1.0 N 0.643 0.364 0.235664433957 gnomAD-4.0.0 2.1074E-05 None None None None N None 1.33554E-05 1.6675E-05 None 0 2.23164E-05 None 0 0 2.45846E-05 2.19597E-05 0
E/D 23695 Ig-130 59 rs1709558707 0.1409 None 0.825 N 0.457 0.096 0.215869574891 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/D 23695 Ig-130 59 rs1709558707 0.1409 None 0.825 N 0.457 0.096 0.215869574891 gnomAD-4.0.0 6.57419E-06 None None None None N None 2.41208E-05 0 None 0 0 None 0 0 0 0 0
D/G 24091 Ig-131 63 rs749484938 0.288 -0.138 1.0 N 0.696 0.476 0.198526703765 gnomAD-2.1.1 5.24E-05 None None None None N None 0 0 None 1.20024E-03 0 None 0 None 0 8.89E-06 0
D/G 24091 Ig-131 63 rs749484938 0.288 -0.138 1.0 N 0.696 0.476 0.198526703765 gnomAD-3.1.2 4.6E-05 None None None None N None 0 0 0 2.01729E-03 0 None 0 0 0 0 0
D/G 24091 Ig-131 63 rs749484938 0.288 -0.138 1.0 N 0.696 0.476 0.198526703765 gnomAD-4.0.0 2.48323E-05 None None None None N None 0 0 None 1.21869E-03 0 None 0 0 3.3964E-06 0 0
D/H 24091 Ig-131 63 rs878924658 0.5291 -0.66 1.0 N 0.682 0.422 None gnomAD-2.1.1 2.82E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.23E-05 0
D/H 24091 Ig-131 63 rs878924658 0.5291 -0.66 1.0 N 0.682 0.422 None gnomAD-4.0.0 1.02842E-05 None None None None N None 0 0 None 0 0 None 0 0 1.35181E-05 0 0
N/K 24488 Ig-132 58 rs1223093442 0.4156 None 1.0 N 0.719 0.285 0.203808441222 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/K 24488 Ig-132 58 rs1223093442 0.4156 None 1.0 N 0.719 0.285 0.203808441222 gnomAD-4.0.0 6.57566E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47089E-05 0 0
D/G 24777 Ig-133 62 None 0.2199 None 0.001 N 0.249 0.167 0.168933306366 gnomAD-4.0.0 1.59276E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86123E-06 0 0
D/E 25173 Ig-134 63 rs1707836839 0.1475 None None N 0.151 0.052 0.0551355673512 gnomAD-4.0.0 1.59189E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85915E-06 0 0
D/H 25173 Ig-134 63 rs980015868 0.4701 None 0.773 N 0.383 0.443 0.193865811164 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
D/H 25173 Ig-134 63 rs980015868 0.4701 None 0.773 N 0.383 0.443 0.193865811164 gnomAD-4.0.0 7.43784E-06 None None None None N None 0 0 None 0 0 None 0 0 1.01725E-05 0 0
N/K 25570 Ig-135 57 None 0.2259 None 0.698 N 0.371 0.159 0.0762999501168 gnomAD-4.0.0 1.59235E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43406E-05 0
N/S 25570 Ig-135 57 None 0.083 None 0.058 N 0.331 0.137 0.115124310173 gnomAD-4.0.0 1.59235E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85984E-06 0 0
E/D 25859 Ig-136 62 None 0.1174 None 0.006 N 0.185 0.04 0.166414681773 gnomAD-4.0.0 1.59193E-06 None None None None N None 0 0 None 0 2.77485E-05 None 0 0 0 0 0
E/K 25859 Ig-136 62 rs1706857293 0.6028 None 0.822 N 0.394 0.169 0.191931220699 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 25859 Ig-136 62 rs1706857293 0.6028 None 0.822 N 0.394 0.169 0.191931220699 gnomAD-4.0.0 6.57765E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47089E-05 0 0
D/H 26255 Ig-137 63 None 0.8266 None 0.999 N 0.666 0.447 0.248417906384 gnomAD-4.0.0 1.38675E-06 None None None None I None 0 0 None 0 0 None 0 0 1.81081E-06 0 0
D/N 26255 Ig-137 63 rs1368108260 0.3684 0.2 0.993 N 0.684 0.355 0.184867976434 gnomAD-2.1.1 8.7E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.88E-05 0
D/N 26255 Ig-137 63 rs1368108260 0.3684 0.2 0.993 N 0.684 0.355 0.184867976434 gnomAD-4.0.0 1.38675E-06 None None None None I None 0 0 None 0 0 None 0 0 1.81081E-06 0 0
N/I 27735 Ig-141 60 None 0.5951 None 1.0 N 0.76 0.447 0.532168211543 gnomAD-4.0.0 6.8429E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99502E-07 0 0
N/K 27735 Ig-141 60 None 0.3687 None 1.0 N 0.721 0.324 0.143124449307 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/T 27735 Ig-141 60 None 0.224 None 0.999 N 0.708 0.425 0.314417295294 gnomAD-4.0.0 6.8429E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99502E-07 0 0
E/D 28024 Ig-142 62 rs377540780 0.1076 -0.417 0.002 N 0.183 0.06 0.0611884634855 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.97E-06 0
E/D 28024 Ig-142 62 rs377540780 0.1076 -0.417 0.002 N 0.183 0.06 0.0611884634855 gnomAD-3.1.2 4.6E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 8.82E-05 0 0
E/D 28024 Ig-142 62 rs377540780 0.1076 -0.417 0.002 N 0.183 0.06 0.0611884634855 gnomAD-4.0.0 2.35544E-05 None None None None N None 2.66994E-05 0 None 0 0 None 0 0 2.88221E-05 0 3.20318E-05
E/G 28024 Ig-142 62 None 0.2724 None 0.822 N 0.476 0.275 0.278143212241 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 28419 Ig-143 62 None 0.1598 None 0.032 N 0.274 0.142 0.0846915920261 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/Y 28419 Ig-143 62 rs1703397478 0.2561 None 0.997 N 0.677 0.396 0.51028768548 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/G 29106 Ig-145 62 rs1559263086 0.3456 None 0.892 N 0.541 0.307 0.29132392195 gnomAD-4.0.0 1.59101E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85776E-06 0 0
N/H 30193 Ig-148 62 rs1168404090 0.1668 -1.048 0.059 N 0.386 0.091 0.195762928549 gnomAD-2.1.1 4.13E-06 None None None None N None 0 3E-05 None 0 0 None 0 None 0 0 0
N/H 30193 Ig-148 62 rs1168404090 0.1668 -1.048 0.059 N 0.386 0.091 0.195762928549 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
N/H 30193 Ig-148 62 rs1168404090 0.1668 -1.048 0.059 N 0.386 0.091 0.195762928549 gnomAD-4.0.0 2.48845E-06 None None None None N None 0 3.39213E-05 None 0 0 None 0 0 1.69846E-06 0 0
N/K 30193 Ig-148 62 rs779880537 0.4494 -0.298 0.896 N 0.425 0.076 0.1749357433 gnomAD-2.1.1 4.1E-06 None None None None N None 0 0 None 0 0 None 3.44E-05 None 0 0 0
N/K 30193 Ig-148 62 rs779880537 0.4494 -0.298 0.896 N 0.425 0.076 0.1749357433 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/K 30193 Ig-148 62 rs779880537 0.4494 -0.298 0.896 N 0.425 0.076 0.1749357433 gnomAD-4.0.0 2.57445E-06 None None None None N None 0 0 None 0 0 None 0 0 4.80141E-06 0 0
D/A 30588 Ig-149 57 None 0.4356 None 0.946 N 0.645 0.314 0.315903272564 gnomAD-4.0.0 6.84216E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99484E-07 0 0
D/G 30588 Ig-149 57 rs756837722 0.36 -0.012 0.834 N 0.646 0.318 0.170165803431 gnomAD-2.1.1 7.14E-06 None None None None N None 4.13E-05 0 None 0 0 None 3.27E-05 None 0 0 0
D/G 30588 Ig-149 57 rs756837722 0.36 -0.012 0.834 N 0.646 0.318 0.170165803431 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 2.07383E-04 0
D/G 30588 Ig-149 57 rs756837722 0.36 -0.012 0.834 N 0.646 0.318 0.170165803431 gnomAD-4.0.0 3.0985E-06 None None None None N None 1.33483E-05 0 None 0 0 None 0 0 0 4.39203E-05 0
D/H 30588 Ig-149 57 rs878854399 0.5459 -0.236 0.077 N 0.421 0.141 0.124217242631 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/H 30588 Ig-149 57 rs878854399 0.5459 -0.236 0.077 N 0.421 0.141 0.124217242631 gnomAD-4.0.0 3.18262E-06 None None None None N None 0 2.28645E-05 None 0 0 None 0 0 0 0 3.02444E-05
N/T 30985 Ig-150 59 rs748877597 0.1787 0.283 0.801 N 0.367 0.135 0.262175524916 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 9.8E-05 None 0 0 0
N/T 30985 Ig-150 59 rs748877597 0.1787 0.283 0.801 N 0.367 0.135 0.262175524916 gnomAD-4.0.0 2.73676E-06 None None None None I None 0 0 None 0 0 None 0 0 0 4.63725E-05 0
F/L 31677 Ig-152 57 rs1559147244 0.8851 None 0.027 N 0.329 0.127 0.33440975612 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
F/S 31677 Ig-152 57 None 0.3187 None 0.002 N 0.197 0.129 0.346085882481 gnomAD-4.0.0 1.59125E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85835E-06 0 0
K/R 32074 Ig-153 58 None 0.0852 None 0.998 N 0.546 0.235 0.152612264143 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/D 32368 Ig-154 62 None 0.1222 None 0.104 N 0.231 0.017 0.0846915920261 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31253E-06 0 0
E/K 32368 Ig-154 62 rs1695208937 0.4914 None 0.994 N 0.523 0.339 0.233785782151 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/K 32368 Ig-154 62 rs1695208937 0.4914 None 0.994 N 0.523 0.339 0.233785782151 gnomAD-4.0.0 6.57402E-06 None None None None N None 2.41383E-05 0 None 0 0 None 0 0 0 0 0
E/A 32764 Ig-155 57 None 0.166 -0.226 0.939 N 0.551 0.242 0.239305524855 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
E/A 32764 Ig-155 57 None 0.166 -0.226 0.939 N 0.551 0.242 0.239305524855 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/A 32764 Ig-155 57 None 0.166 -0.226 0.939 N 0.551 0.242 0.239305524855 gnomAD-4.0.0 5.12407E-06 None None None None N None 0 0 None 0 0 None 0 0 9.57213E-06 0 0
E/G 32764 Ig-155 57 rs755276825 0.1294 -0.563 0.939 N 0.545 0.292 0.251116650651 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 1.11421E-04 None 0 None 0 0 0
E/G 32764 Ig-155 57 rs755276825 0.1294 -0.563 0.939 N 0.545 0.292 0.251116650651 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92827E-04 None 0 0 0 0 0
E/G 32764 Ig-155 57 rs755276825 0.1294 -0.563 0.939 N 0.545 0.292 0.251116650651 gnomAD-4.0.0 3.84305E-06 None None None None N None 0 0 None 0 7.27273E-05 None 0 0 0 0 0
E/K 32764 Ig-155 57 rs781604869 0.2604 0.663 0.939 N 0.505 0.258 0.190952846119 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
E/K 32764 Ig-155 57 rs781604869 0.2604 0.663 0.939 N 0.505 0.258 0.190952846119 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 32764 Ig-155 57 rs781604869 0.2604 0.663 0.939 N 0.505 0.258 0.190952846119 gnomAD-4.0.0 7.6862E-06 None None None None N None 0 0 None 0 0 None 0 0 1.43578E-05 0 0
T/I 33162 Ig-156 62 None 0.8075 None 1.0 N 0.717 0.452 0.260735089382 gnomAD-4.0.0 6.84224E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99478E-07 0 0
N/H 33258 Ig-157 56 None 0.2083 None 0.999 N 0.609 0.369 0.270889551736 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
G/R 33658 Ig-159 63 rs780484535 0.8029 -1.375 1.0 N 0.847 0.517 0.511503663882 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 1.30727E-04 None 0 0 0
G/R 33658 Ig-159 63 rs780484535 0.8029 -1.375 1.0 N 0.847 0.517 0.511503663882 gnomAD-4.0.0 9.57908E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59789E-06 9.27579E-05 3.31301E-05
D/E 34198 Ig-160 62 rs778876835 0.2597 -0.049 0.999 N 0.474 0.152 0.21737058555 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
D/H 34198 Ig-160 62 rs948836784 0.4195 None 1.0 N 0.764 0.298 0.215109475489 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
D/H 34198 Ig-160 62 rs948836784 0.4195 None 1.0 N 0.764 0.298 0.215109475489 gnomAD-4.0.0 6.57091E-06 None None None None N None 0 6.54965E-05 None 0 0 None 0 0 0 0 0
D/N 34198 Ig-160 62 rs948836784 0.1087 None 0.999 N 0.709 0.217 0.141422826196 gnomAD-4.0.0 3.182E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71533E-06 0 0
S/N 34322 Ig-161 65 rs763242057 0.0637 -0.911 None N 0.12 0.062 0.0482279557977 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 0 None 4.64E-05 3.55E-05 0
S/N 34322 Ig-161 65 rs763242057 0.0637 -0.911 None N 0.12 0.062 0.0482279557977 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 9.42E-05 0 2.94E-05 0 0
S/N 34322 Ig-161 65 rs763242057 0.0637 -0.911 None N 0.12 0.062 0.0482279557977 gnomAD-4.0.0 2.72646E-05 None None None None N None 0 0 None 0 0 None 3.1251E-05 0 3.47496E-05 0 1.60097E-05
S/R 34322 Ig-161 65 None 0.2448 None 0.029 N 0.414 0.211 0.0482279557977 gnomAD-4.0.0 1.59102E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
S/T 34322 Ig-161 65 rs763242057 0.1067 -0.751 0.012 N 0.395 0.037 0.0716867268079 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
S/T 34322 Ig-161 65 rs763242057 0.1067 -0.751 0.012 N 0.395 0.037 0.0716867268079 gnomAD-4.0.0 6.84165E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99412E-07 0 0
D/E 34425 Ig-162 63 rs752444322 0.4177 -0.055 0.061 N 0.191 0.145 0.0884992946249 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/N 34425 Ig-162 63 None 0.208 None 0.134 N 0.328 0.228 0.293502639404 gnomAD-4.0.0 2.05283E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.47818E-05 0
D/A 35003 Ig-163 62 None 0.4222 None 1.0 N 0.761 0.516 0.317084106153 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
D/N 35003 Ig-163 62 None 0.1294 None 1.0 N 0.635 0.3 0.185906805712 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/Y 35003 Ig-163 62 None 0.5617 None 1.0 N 0.767 0.326 0.377097596864 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/H 35348 Ig-165 63 rs1688670150 0.0962 None 0.794 N 0.265 0.268 0.314716216878 gnomAD-4.0.0 3.18173E-06 None None None None N None 0 0 None 0 5.54508E-05 None 0 0 0 0 0
N/K 35348 Ig-165 63 rs145560044 0.2915 -0.049 0.213 N 0.189 0.133 0.221019684889 gnomAD-2.1.1 1.39125E-04 None None None None N None 8.27E-05 1.04638E-03 None 0 0 None 0 None 0 0 0
N/K 35348 Ig-165 63 rs145560044 0.2915 -0.049 0.213 N 0.189 0.133 0.221019684889 gnomAD-3.1.2 5.91E-05 None None None None N None 2.41E-05 5.23492E-04 0 0 0 None 0 0 0 0 0
N/K 35348 Ig-165 63 rs145560044 0.2915 -0.049 0.213 N 0.189 0.133 0.221019684889 gnomAD-4.0.0 4.58522E-05 None None None None N None 2.6698E-05 1.09993E-03 None 0 0 None 0 0 5.08517E-06 0 0
K/R 35481 Ig-166 62 rs200716018 0.0927 0.253 0.157 N 0.337 0.135 None gnomAD-2.1.1 4.67E-05 None None None None N None 8.28E-05 5.74E-05 None 0 0 None 0 None 0 6.26E-05 1.40964E-04
K/R 35481 Ig-166 62 rs200716018 0.0927 0.253 0.157 N 0.337 0.135 None gnomAD-3.1.2 1.05128E-04 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.20504E-04 0 0
K/R 35481 Ig-166 62 rs200716018 0.0927 0.253 0.157 N 0.337 0.135 None gnomAD-4.0.0 1.60703E-04 None None None None N None 1.33618E-05 0 None 0 0 None 0 0 2.00969E-04 0 3.36636E-04
Q/E 35666 Ig-167 60 rs750660824 0.0812 -1.935 0.019 N 0.382 0.054 0.0920862733494 gnomAD-2.1.1 1.44E-05 None None None None N None 4.19E-05 0 None 0 0 None 0 None 0 2.36E-05 0
Q/E 35666 Ig-167 60 rs750660824 0.0812 -1.935 0.019 N 0.382 0.054 0.0920862733494 gnomAD-3.1.2 3.29E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 5.88E-05 0 0
Q/E 35666 Ig-167 60 rs750660824 0.0812 -1.935 0.019 N 0.382 0.054 0.0920862733494 gnomAD-4.0.0 1.30299E-05 None None None None N None 4.00662E-05 0 None 0 0 None 0 0 1.35703E-05 0 3.20883E-05
Q/K 35666 Ig-167 60 None 0.0763 -0.457 None N 0.107 0.069 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 2.82859E-04 0 1.47E-05 0 0
Q/K 35666 Ig-167 60 None 0.0763 -0.457 None N 0.107 0.069 None gnomAD-4.0.0 2.35783E-05 None None None None N None 1.33554E-05 3.35132E-05 None 0 6.70901E-05 None 2.04608E-04 0 1.27222E-05 0 6.41787E-05
Q/R 35666 Ig-167 60 None 0.0979 None 0.042 N 0.447 0.054 0.0846915920261 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/K 35763 Ig-168 62 None 0.3426 None 0.004 N 0.305 0.068 0.0666544352282 gnomAD-4.0.0 1.591E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.