Structural position:

  • Domain Type: Ig
  • Aligned Position: 146
  • Secondary Structure Element: h
  • Secondary Structure Region: ⍺-helix

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
K/E 72 Ig-1 67 None 0.1276 None None N 0.1 0.208 0.134241683229 gnomAD-4.0.0 2.05223E-06 None None None -0.014(TCAP) N None 0 0 None 0 0 None 0 0 0 1.15931E-05 3.3117E-05
K/T 72 Ig-1 67 rs1200039660 0.1224 -0.19 0.006 N 0.257 0.136 0.183819452728 gnomAD-2.1.1 3.98E-06 None None None -0.515(TCAP) N None 0 0 None 0 0 None 0 None 0 8.8E-06 0
P/L 168 Ig-2 65 None 0.4337 None 1.0 N 0.76 0.456 0.759971447399 gnomAD-4.0.0 4.77133E-06 None None None -0.896(TCAP) N None 0 0 None 0 0 None 0 0 8.56937E-06 0 0
A/T 1007 Ig-3 65 None 0.3839 None 1.0 N 0.619 0.342 0.36355261348 gnomAD-4.0.0 1.36819E-06 None None None None N None 0 4.47247E-05 None 0 0 None 0 0 0 0 0
A/V 1007 Ig-3 65 rs749564348 0.5242 -0.374 1.0 N 0.547 0.368 0.525049811399 gnomAD-2.1.1 1.2E-05 None None None None N None 6.15E-05 0 None 0 0 None 0 None 0 8.83E-06 1.63506E-04
A/T 1148 Ig-4 67 rs889422639 0.2413 -0.141 0.992 N 0.528 0.292 0.221734844693 gnomAD-2.1.1 7.08E-06 None None None None I None 4.01E-05 0 None 0 0 None 0 None 0 7.76E-06 0
A/T 1148 Ig-4 67 rs889422639 0.2413 -0.141 0.992 N 0.528 0.292 0.221734844693 gnomAD-3.1.2 1.31E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
A/T 1148 Ig-4 67 rs889422639 0.2413 -0.141 0.992 N 0.528 0.292 0.221734844693 gnomAD-4.0.0 3.84216E-06 None None None None I None 3.38181E-05 0 None 0 0 None 0 0 2.39197E-06 0 0
A/V 1148 Ig-4 67 None 0.3853 None 0.998 N 0.573 0.394 0.348983352498 gnomAD-4.0.0 1.59082E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
P/L 1522 Ig-6 66 None 0.0882 None 1.0 D 0.789 0.486 0.749107425127 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
P/S 1522 Ig-6 66 rs1261123391 0.1121 -0.023 1.0 D 0.749 0.522 0.496364318313 gnomAD-2.1.1 3.99E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
P/S 1522 Ig-6 66 rs1261123391 0.1121 -0.023 1.0 D 0.749 0.522 0.496364318313 gnomAD-4.0.0 1.59127E-06 None None None None N None 0 2.28739E-05 None 0 0 None 0 0 0 0 0
S/N 1622 Ig-7 67 None 0.1105 None 0.801 N 0.177 0.148 0.0954503805726 gnomAD-4.0.0 1.59079E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
S/R 1622 Ig-7 67 rs2092294772 0.3013 None 0.012 N 0.169 0.227 0.132336055621 gnomAD-4.0.0 1.59079E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8566E-06 0 0
S/P 1769 Ig-8 67 None 0.0857 None 0.002 N 0.137 0.316 0.0920862733494 gnomAD-4.0.0 1.59371E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85659E-06 0 0
A/V 2143 Ig-10 66 rs1561277273 0.0929 None 0.009 N 0.231 0.271 0.378322506985 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
T/A 2238 Ig-11 65 rs747377115 0.0615 0.153 None N 0.055 0.055 0.0138822411134 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 5.45E-05 None 0 None 0 0 0
T/A 2238 Ig-11 65 rs747377115 0.0615 0.153 None N 0.055 0.055 0.0138822411134 gnomAD-4.0.0 6.84129E-07 None None None None N None 0 0 None 0 2.52131E-05 None 0 0 0 0 0
T/K 2238 Ig-11 65 None 0.0761 None None N 0.141 0.078 0.0297737177859 gnomAD-4.0.0 6.84146E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9936E-07 0 0
T/M 2238 Ig-11 65 rs201284459 0.056 0.279 0.002 N 0.094 0.077 None gnomAD-2.1.1 1.62834E-04 None None None None N None 8.01E-05 3.67252E-04 None 0 0 None 3.27E-05 None 0 2.09387E-04 4.1632E-04
T/M 2238 Ig-11 65 rs201284459 0.056 0.279 0.002 N 0.094 0.077 None gnomAD-3.1.2 5.26E-05 None None None None N None 2.41E-05 1.96515E-04 0 0 0 None 0 0 5.88E-05 0 0
T/M 2238 Ig-11 65 rs201284459 0.056 0.279 0.002 N 0.094 0.077 None gnomAD-4.0.0 1.17733E-04 None None None None N None 4.00438E-05 3.16772E-04 None 0 0 None 0 1.6442E-03 1.17804E-04 7.68572E-05 1.92074E-04
T/P 2238 Ig-11 65 rs747377115 0.0768 None 0.055 N 0.305 0.034 0.0297737177859 gnomAD-4.0.0 1.23143E-05 None None None None N None 0 0 None 0 0 None 0 0 1.61882E-05 0 0
T/R 2238 Ig-11 65 rs201284459 0.0729 0.409 0.07 N 0.338 0.064 0.0666544352282 gnomAD-2.1.1 2.39E-05 None None None None N None 0 5.79E-05 None 0 0 None 1.30676E-04 None 0 0 0
T/R 2238 Ig-11 65 rs201284459 0.0729 0.409 0.07 N 0.338 0.064 0.0666544352282 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
T/R 2238 Ig-11 65 rs201284459 0.0729 0.409 0.07 N 0.338 0.064 0.0666544352282 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
T/R 2238 Ig-11 65 rs201284459 0.0729 0.409 0.07 N 0.338 0.064 0.0666544352282 gnomAD-4.0.0 1.11528E-05 None None None None N None 0 5E-05 None 0 2.22975E-05 None 0 0 0 1.53721E-04 0
K/N 2330 Ig-12 64 None 0.4578 None 0.993 N 0.569 0.15 0.124217242631 gnomAD-4.0.0 2.05222E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79861E-06 0 1.65574E-05
A/V 2509 Ig-14 65 None 0.1497 None 0.999 N 0.589 0.263 0.291694819147 gnomAD-4.0.0 1.59071E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85672E-06 0 0
L/S 2683 Ig-16 63 rs770445596 0.3211 -1.332 0.891 N 0.351 0.311 0.508934680445 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.8E-06 0
L/S 2683 Ig-16 63 rs770445596 0.3211 -1.332 0.891 N 0.351 0.311 0.508934680445 gnomAD-4.0.0 1.59061E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85656E-06 0 0
L/V 2683 Ig-16 63 rs761118672 0.1087 -0.998 0.012 N 0.175 0.058 0.104622674875 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 4.62E-05 0 0
L/V 2683 Ig-16 63 rs761118672 0.1087 -0.998 0.012 N 0.175 0.058 0.104622674875 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.42E-05 0 0 0 0
L/V 2683 Ig-16 63 rs761118672 0.1087 -0.998 0.012 N 0.175 0.058 0.104622674875 gnomAD-4.0.0 2.56131E-06 None None None None N None 0 0 None 0 0 None 3.13706E-05 0 0 0 0
I/M 2771 Ig-17 65 rs576644663 0.0785 -0.171 0.001 N 0.213 0.254 0.0920862733494 gnomAD-2.1.1 1.06E-05 None None None None I None 0 0 None 0 1.50678E-04 None 0 None 0 0 0
I/M 2771 Ig-17 65 rs576644663 0.0785 -0.171 0.001 N 0.213 0.254 0.0920862733494 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.9253E-04 None 0 0 0 0 0
I/M 2771 Ig-17 65 rs576644663 0.0785 -0.171 0.001 N 0.213 0.254 0.0920862733494 gnomAD-4.0.0 1.85874E-06 None None None None I None 0 0 None 0 6.68509E-05 None 0 0 0 0 0
I/T 2771 Ig-17 65 rs780465670 0.0857 -0.128 None N 0.089 0.244 None gnomAD-2.1.1 1.42E-05 None None None None I None 4.01E-05 0 None 0 0 None 0 None 0 2.33E-05 0
I/T 2771 Ig-17 65 rs780465670 0.0857 -0.128 None N 0.089 0.244 None gnomAD-3.1.2 4.6E-05 None None None None I None 9.65E-05 0 0 0 0 None 0 0 4.41E-05 0 0
I/T 2771 Ig-17 65 rs780465670 0.0857 -0.128 None N 0.089 0.244 None gnomAD-4.0.0 5.20422E-05 None None None None I None 6.67111E-05 0 None 0 0 None 0 0 6.52526E-05 0 3.20072E-05
I/V 2771 Ig-17 65 rs1416391085 0.0595 0.041 None N 0.081 0.216 0.339793275041 gnomAD-2.1.1 3.18E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
I/V 2771 Ig-17 65 rs1416391085 0.0595 0.041 None N 0.081 0.216 0.339793275041 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 2771 Ig-17 65 rs1416391085 0.0595 0.041 None N 0.081 0.216 0.339793275041 gnomAD-4.0.0 6.56935E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46972E-05 0 0
P/L 2858 Ig-18 64 rs370094744 0.1105 -0.063 0.549 N 0.383 0.299 None gnomAD-2.1.1 1.42E-05 None None None None N None 1.20163E-04 0 None 0 0 None 3.27E-05 None 0 0 0
P/L 2858 Ig-18 64 rs370094744 0.1105 -0.063 0.549 N 0.383 0.299 None gnomAD-3.1.2 2.63E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
P/L 2858 Ig-18 64 rs370094744 0.1105 -0.063 0.549 N 0.383 0.299 None gnomAD-4.0.0 7.435E-06 None None None None N None 8.00961E-05 0 None 0 0 None 0 0 8.47448E-07 5.48992E-05 0
P/R 2858 Ig-18 64 rs370094744 0.1899 None 0.379 N 0.33 0.261 0.267755039894 gnomAD-4.0.0 6.84067E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65574E-05
T/A 2945 Ig-19 64 None 0.0658 None 0.005 N 0.128 0.105 0.139678290688 gnomAD-4.0.0 3.18102E-06 None None None None N None 0 0 None 0 0 None 3.76393E-05 0 0 0 0
M/I 3121 Ig-21 64 rs200413367 0.5676 0.365 0.828 N 0.387 0.206 0.287603790349 gnomAD-2.1.1 7.57E-05 None None None None I None 0 0 None 1.1919E-03 0 None 0 None 0 4.41E-05 3.26584E-04
M/I 3121 Ig-21 64 rs200413367 0.5676 0.365 0.828 N 0.387 0.206 0.287603790349 gnomAD-3.1.2 6.57E-05 None None None None I None 0 6.55E-05 0 2.01729E-03 0 None 0 0 2.94E-05 0 0
M/I 3121 Ig-21 64 rs200413367 0.5676 0.365 0.828 N 0.387 0.206 0.287603790349 gnomAD-4.0.0 4.58483E-05 None None None None I None 0 1.66672E-05 None 1.51996E-03 0 None 0 0 1.61016E-05 0 1.44032E-04
M/V 3121 Ig-21 64 None 0.2079 None 0.828 N 0.395 0.177 0.258779203287 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/K 3212 Ig-22 66 rs1226969863 0.0961 0.37 0.001 N 0.175 0.078 0.0611884634855 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 6.41849E-04 None 0 None 0 0 0
Q/K 3212 Ig-22 66 rs1226969863 0.0961 0.37 0.001 N 0.175 0.078 0.0611884634855 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92604E-04 None 0 0 0 0 0
Q/K 3212 Ig-22 66 rs1226969863 0.0961 0.37 0.001 N 0.175 0.078 0.0611884634855 gnomAD-4.0.0 6.57125E-06 None None None None N None 0 0 None 0 1.92604E-04 None 0 0 0 0 0
P/L 3303 Ig-23 65 rs201379132 0.3637 -0.043 0.999 N 0.704 0.527 0.675724534598 gnomAD-2.1.1 1.09754E-04 None None None None N None 0 0 None 0 0 None 8.16567E-04 None 0 4.66E-05 0
P/L 3303 Ig-23 65 rs201379132 0.3637 -0.043 0.999 N 0.704 0.527 0.675724534598 gnomAD-3.1.2 4.6E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 4.41E-05 6.22407E-04 0
P/L 3303 Ig-23 65 rs201379132 0.3637 -0.043 0.999 N 0.704 0.527 0.675724534598 gnomAD-4.0.0 6.13382E-05 None None None None N None 1.33461E-05 0 None 0 0 None 0 0 1.94914E-05 8.12508E-04 1.60036E-05
S/L 3531 Ig-25 67 None 0.187 None None None None 0.116 None gnomAD-4.0.0 1.59152E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85894E-06 0 0
S/T 3531 Ig-25 67 rs1422997760 0.1408 -0.034 None None None 0.09 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
S/T 3531 Ig-25 67 rs1422997760 0.1408 -0.034 None None None 0.09 None gnomAD-4.0.0 3.18301E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71788E-06 0 0
L/W 3884 Ig-27 65 rs2082489145 0.1052 None 0.196 N 0.274 0.039 None gnomAD-4.0.0 1.59118E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85807E-06 0 0
R/K 4003 Ig-28 66 None 0.0738 None None N 0.107 0.098 None gnomAD-4.0.0 1.59205E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85796E-06 0 0
T/A 4668 Ig-29 63 rs758920941 0.062 -0.383 None N 0.063 0.024 None gnomAD-2.1.1 3.79E-05 None None None None N None 0 0 None 0 0 None 0 None 0 8.22E-05 0
T/A 4668 Ig-29 63 rs758920941 0.062 -0.383 None N 0.063 0.024 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
T/A 4668 Ig-29 63 rs758920941 0.062 -0.383 None N 0.063 0.024 None gnomAD-4.0.0 2.08029E-05 None None None None N None 0 0 None 0 0 None 0 0 2.49281E-05 0 6.52763E-05
L/M 4952 Ig-32 65 rs781546825 0.0884 -0.259 0.864 N 0.555 0.144 0.322230723748 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
V/F 5046 Ig-33 66 rs1395287554 0.2484 None 0.994 N 0.353 0.322 0.469248961376 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/F 5046 Ig-33 66 rs1395287554 0.2484 None 0.994 N 0.353 0.322 0.469248961376 gnomAD-4.0.0 1.23941E-06 None None None None I None 1.33479E-05 0 None 0 0 None 0 0 0 1.09818E-05 0
V/I 5046 Ig-33 66 rs1395287554 0.0872 -0.13 0.248 N 0.279 0.113 0.244539031024 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/I 5046 Ig-33 66 rs1395287554 0.0872 -0.13 0.248 N 0.279 0.113 0.244539031024 gnomAD-4.0.0 1.36848E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99504E-07 1.15977E-05 0
S/G 5139 Ig-34 65 rs876658040 0.1055 None 0.999 N 0.423 0.538 0.394685799254 gnomAD-4.0.0 1.59162E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85884E-06 0 0
S/N 5139 Ig-34 65 rs2081075120 0.2207 None 0.999 N 0.496 0.343 0.352048277211 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/N 5139 Ig-34 65 rs2081075120 0.2207 None 0.999 N 0.496 0.343 0.352048277211 gnomAD-4.0.0 1.85922E-06 None None None None I None 0 1.66717E-05 None 0 0 None 0 0 1.69532E-06 0 0
I/L 5232 Ig-35 65 None 0.0741 None None N 0.079 0.046 0.253205268125 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
M/T 5421 Ig-37 65 rs1304285904 0.0844 0.722 None N 0.141 0.224 0.459729313489 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
M/T 5421 Ig-37 65 rs1304285904 0.0844 0.722 None N 0.141 0.224 0.459729313489 gnomAD-4.0.0 2.05305E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69859E-06 0 0
M/V 5421 Ig-37 65 rs1353177231 0.0618 0.27 None N 0.125 0.148 0.163833314356 gnomAD-2.1.1 4.03E-06 None None None None I None 6.47E-05 0 None 0 0 None 0 None 0 0 0
T/I 5514 Ig-38 65 None 0.1097 None 0.004 N 0.175 0.088 0.163833314356 gnomAD-4.0.0 1.59152E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85847E-06 0 0
T/N 5514 Ig-38 65 rs2080735339 0.0828 None 0.896 N 0.247 0.178 0.197625483188 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/N 5514 Ig-38 65 rs2080735339 0.0828 None 0.896 N 0.247 0.178 0.197625483188 gnomAD-4.0.0 6.57255E-06 None None None None I None 2.41336E-05 0 None 0 0 None 0 0 0 0 0
A/D 5701 Ig-40 65 rs757714302 0.1996 -0.171 0.801 N 0.341 0.199 0.408714661073 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
A/D 5701 Ig-40 65 rs757714302 0.1996 -0.171 0.801 N 0.341 0.199 0.408714661073 gnomAD-4.0.0 1.36844E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79897E-06 0 0
V/I 5794 Ig-41 65 rs879167621 0.0769 None 0.001 N 0.125 0.084 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
V/I 5794 Ig-41 65 rs879167621 0.0769 None 0.001 N 0.125 0.084 None gnomAD-4.0.0 1.31458E-05 None None None None N None 4.82719E-05 0 None 0 0 None 0 0 0 0 0
K/N 5887 Ig-42 65 rs878956662 0.3211 None 0.999 N 0.594 0.247 0.185906805712 gnomAD-4.0.0 1.23174E-05 None None None None N None 0 0 None 0 0 None 0 0 1.61917E-05 0 0
K/R 5887 Ig-42 65 rs527439656 0.0853 0.34 0.996 N 0.486 0.169 0.199424873507 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 5.56E-05 None 3.27E-05 None 0 0 0
K/R 5887 Ig-42 65 rs527439656 0.0853 0.34 0.996 N 0.486 0.169 0.199424873507 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.93125E-04 None 0 0 0 0 0
K/R 5887 Ig-42 65 rs527439656 0.0853 0.34 0.996 N 0.486 0.169 0.199424873507 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
K/R 5887 Ig-42 65 rs527439656 0.0853 0.34 0.996 N 0.486 0.169 0.199424873507 gnomAD-4.0.0 5.57734E-06 None None None None N None 0 0 None 0 2.22926E-05 None 0 0 8.4767E-07 6.5908E-05 1.60061E-05
G/A 5983 Ig-43 65 rs775766481 0.0807 0.226 0.003 N 0.267 0.104 0.0551355673512 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
G/A 5983 Ig-43 65 rs775766481 0.0807 0.226 0.003 N 0.267 0.104 0.0551355673512 gnomAD-3.1.2 1.97E-05 None None None None N None 4.83E-05 6.55E-05 0 0 0 None 0 0 0 0 0
G/A 5983 Ig-43 65 rs775766481 0.0807 0.226 0.003 N 0.267 0.104 0.0551355673512 gnomAD-4.0.0 3.09885E-06 None None None None N None 2.67094E-05 1.66744E-05 None 0 0 None 0 0 0 0 3.20277E-05
G/D 5983 Ig-43 65 None 0.1303 None 0.505 N 0.309 0.122 0.101711395817 gnomAD-4.0.0 1.36855E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79912E-06 0 0
G/S 5983 Ig-43 65 rs1283178531 0.0813 -0.026 0.001 N 0.153 0.063 0.0666544352282 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
G/S 5983 Ig-43 65 rs1283178531 0.0813 -0.026 0.001 N 0.153 0.063 0.0666544352282 gnomAD-4.0.0 6.36657E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.73132E-05 0
A/S 6076 Ig-44 65 rs371110666 0.0846 -0.076 None N 0.071 0.048 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
A/S 6076 Ig-44 65 rs371110666 0.0846 -0.076 None N 0.071 0.048 None gnomAD-4.0.0 6.8435E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99541E-07 0 0
A/T 6076 Ig-44 65 None 0.0706 None None N 0.073 0.052 0.0551355673512 gnomAD-4.0.0 1.3687E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79908E-06 0 0
P/A 6263 Ig-46 65 rs753985729 0.0617 None 0.003 N 0.15 0.102 0.0611884634855 gnomAD-4.0.0 6.843E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99572E-07 0 0
P/L 6263 Ig-46 65 None 0.0706 None 0.101 N 0.249 0.077 0.289098819767 gnomAD-4.0.0 1.59172E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85922E-06 0 0
P/S 6263 Ig-46 65 rs753985729 0.0745 0.116 0.007 N 0.212 0.083 0.0666544352282 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
P/S 6263 Ig-46 65 rs753985729 0.0745 0.116 0.007 N 0.212 0.083 0.0666544352282 gnomAD-4.0.0 2.0529E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69872E-06 0 0
N/I 6356 Ig-47 65 rs773854949 0.0992 0.406 0.178 N 0.237 0.158 None gnomAD-2.1.1 4.05E-06 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 0 0
N/I 6356 Ig-47 65 rs773854949 0.0992 0.406 0.178 N 0.237 0.158 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
N/I 6356 Ig-47 65 rs773854949 0.0992 0.406 0.178 N 0.237 0.158 None gnomAD-4.0.0 7.43953E-06 None None None None N None 1.33515E-05 0 None 0 0 None 0 0 9.32554E-06 0 0
N/S 6356 Ig-47 65 None 0.063 None 0.017 N 0.057 0.1 0.0611884634855 gnomAD-4.0.0 6.84532E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99651E-07 0 0
K/R 6449 Ig-48 65 rs1282291767 0.0978 0.186 0.026 N 0.266 0.052 0.0401082797425 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
K/R 6449 Ig-48 65 rs1282291767 0.0978 0.186 0.026 N 0.266 0.052 0.0401082797425 gnomAD-4.0.0 1.59264E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86008E-06 0 0
A/T 6638 Ig-50 65 rs878890344 0.0762 None None N 0.221 0.095 0.0482279557977 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 6638 Ig-50 65 rs878890344 0.0762 None None N 0.221 0.095 0.0482279557977 gnomAD-4.0.0 3.72E-06 None None None None N None 0 0 None 0 0 None 0 0 5.08783E-06 0 0
T/A 6825 Ig-52 65 rs1405860500 0.0531 0.098 None N 0.087 0.109 0.0762999501168 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/I 6825 Ig-52 65 rs763006525 0.0849 0.184 0.012 N 0.283 0.139 0.318540980066 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.45E-05 0
T/I 6825 Ig-52 65 rs763006525 0.0849 0.184 0.012 N 0.283 0.139 0.318540980066 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 7.35E-05 0 0
T/I 6825 Ig-52 65 rs763006525 0.0849 0.184 0.012 N 0.283 0.139 0.318540980066 gnomAD-4.0.0 3.40939E-05 None None None None N None 0 0 None 0 0 None 0 0 4.40857E-05 0 4.80584E-05
P/L 6919 Ig-53 66 None 0.0918 None 0.001 N 0.145 0.134 0.178374595973 gnomAD-4.0.0 1.59365E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43674E-05 0
R/S 7012 Ig-54 65 rs1024577519 0.2014 0.021 0.012 N 0.298 0.067 0.0846915920261 gnomAD-2.1.1 2.14E-05 None None None None I None 2.48057E-04 0 None 0 0 None 0 None 0 0 0
R/S 7012 Ig-54 65 rs1024577519 0.2014 0.021 0.012 N 0.298 0.067 0.0846915920261 gnomAD-3.1.2 5.92E-05 None None None None I None 2.17108E-04 0 0 0 0 None 0 0 0 0 0
R/S 7012 Ig-54 65 rs1024577519 0.2014 0.021 0.012 N 0.298 0.067 0.0846915920261 gnomAD-4.0.0 1.85937E-05 None None None None I None 3.33796E-04 3.33589E-05 None 0 0 None 0 0 0 0 4.80461E-05
I/M 7201 Ig-56 65 None 0.0897 None 0.108 N 0.205 0.022 0.12205267543 gnomAD-4.0.0 2.05328E-06 None None None None I None 5.97943E-05 0 None 0 0 None 0 0 0 0 1.65788E-05
I/V 7201 Ig-56 65 rs755330865 0.059 0.035 None N 0.121 0.035 0.126345400529 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
I/V 7201 Ig-56 65 rs755330865 0.059 0.035 None N 0.121 0.035 0.126345400529 gnomAD-4.0.0 4.1065E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49802E-06 0 1.65782E-05
K/E 7294 Ig-57 65 rs1333823103 0.0914 0.344 0.565 N 0.427 0.193 0.188950314367 gnomAD-2.1.1 1.21E-05 None None None None N None 0 8.71E-05 None 0 0 None 0 None 0 0 0
K/E 7294 Ig-57 65 rs1333823103 0.0914 0.344 0.565 N 0.427 0.193 0.188950314367 gnomAD-4.0.0 4.77528E-06 None None None None N None 0 6.86185E-05 None 0 0 None 0 0 0 0 0
I/L 7387 Ig-58 65 rs1322069971 0.0712 0.029 0.001 N 0.09 0.086 0.0611884634855 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 9.97E-05 0 None 0 None 0 0 0
I/L 7387 Ig-58 65 rs1322069971 0.0712 0.029 0.001 N 0.09 0.086 0.0611884634855 gnomAD-4.0.0 3.18529E-06 None None None None I None 0 0 None 4.77008E-05 0 None 0 0 2.8603E-06 0 0
I/S 7387 Ig-58 65 rs759166844 0.0847 -0.062 0.002 N 0.133 0.202 0.289847578895 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 9.83E-05 None 0 0 0
I/S 7387 Ig-58 65 rs759166844 0.0847 -0.062 0.002 N 0.133 0.202 0.289847578895 gnomAD-4.0.0 4.77812E-06 None None None None I None 0 0 None 0 0 None 0 0 0 4.30219E-05 0
K/N 7579 Ig-60 65 None 0.663 None 0.994 N 0.365 0.262 0.192905019026 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/R 7579 Ig-60 65 rs2078428721 0.093 None 0.014 N 0.233 0.105 0.168933306366 gnomAD-4.0.0 1.59185E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85956E-06 0 0
A/D 7766 Ig-62 65 None 0.2462 None 0.032 N 0.293 0.192 None gnomAD-4.0.0 2.05281E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99551E-07 0 3.31367E-05
A/T 7860 Ig-63 66 rs138076523 0.0808 -0.242 0.051 N 0.225 0.043 None gnomAD-2.1.1 3.62E-05 None None None None N None 0 2.9E-05 None 9.95E-05 3.3415E-04 None 0 None 0 8.89E-06 0
A/T 7860 Ig-63 66 rs138076523 0.0808 -0.242 0.051 N 0.225 0.043 None gnomAD-3.1.2 4.6E-05 None None None None N None 0 0 0 0 1.34979E-03 None 0 0 0 0 0
A/T 7860 Ig-63 66 rs138076523 0.0808 -0.242 0.051 N 0.225 0.043 None 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 2E-03 0 None None None 0 None
A/T 7860 Ig-63 66 rs138076523 0.0808 -0.242 0.051 N 0.225 0.043 None gnomAD-4.0.0 7.25073E-05 None None None None N None 0 3.33311E-05 None 3.37883E-05 2.49666E-03 None 0 0 1.69538E-06 0 0
M/I 7953 Ig-64 65 rs1218890532 0.1576 0.543 0.784 N 0.18 0.144 0.301455362545 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.65837E-04
M/I 7953 Ig-64 65 rs1218890532 0.1576 0.543 0.784 N 0.18 0.144 0.301455362545 gnomAD-4.0.0 1.36846E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.31334E-05
P/L 8049 Ig-65 65 None 0.0849 None 0.001 N 0.214 0.184 0.278968121808 gnomAD-4.0.0 1.59127E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
P/S 8049 Ig-65 65 None 0.082 None None N 0.16 0.136 0.0611884634855 gnomAD-4.0.0 1.59126E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85838E-06 0 0
P/S 8142 Ig-66 65 None 0.1324 None 0.27 N 0.27 0.157 0.104622674875 gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
P/T 8142 Ig-66 65 rs990633841 0.1082 None 0.023 N 0.215 0.177 0.156986980423 gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
P/T 8142 Ig-66 65 rs990633841 0.1082 None 0.023 N 0.215 0.177 0.156986980423 gnomAD-4.0.0 3.04509E-06 None None None None I None 3.49601E-05 0 None 0 0 None 0 0 0 0 3.40252E-05
I/M 8235 Ig-67 65 None 0.0697 None 0.108 N 0.186 0.046 0.287603790349 gnomAD-4.0.0 1.5913E-06 None None None None I None 5.65611E-05 0 None 0 0 None 0 0 0 0 0
I/R 8235 Ig-67 65 None 0.0769 None None N 0.147 0.166 0.343560092441 gnomAD-4.0.0 1.59134E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
I/V 8235 Ig-67 65 rs772492248 0.0592 -0.222 None N 0.111 0.092 0.0954503805726 gnomAD-2.1.1 1.61E-05 None None None None I None 6.46E-05 5.8E-05 None 0 0 None 3.27E-05 None 0 0 0
I/V 8235 Ig-67 65 rs772492248 0.0592 -0.222 None N 0.111 0.092 0.0954503805726 gnomAD-4.0.0 3.42108E-06 None None None None I None 2.98811E-05 2.23614E-05 None 0 0 None 0 0 8.99486E-07 1.15934E-05 1.65667E-05
H/N 8328 Ig-68 65 rs767212475 0.0622 0.233 None N 0.143 0.188 0.190952846119 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
Q/E 8424 Ig-69 65 rs370668637 0.0829 0.573 0.011 N 0.15 0.033 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/E 8424 Ig-69 65 rs370668637 0.0829 0.573 0.011 N 0.15 0.033 None gnomAD-4.0.0 3.40963E-05 None None None None I None 0 0 None 0 0 None 0 0 4.66283E-05 0 0
V/A 8614 Ig-71 66 None 0.1166 None 0.202 N 0.175 0.072 0.220303561663 gnomAD-4.0.0 1.59153E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
A/V 8707 Ig-72 65 rs773760649 0.0771 0.006 None N 0.199 0.023 0.0846915920261 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
A/V 8707 Ig-72 65 rs773760649 0.0771 0.006 None N 0.199 0.023 0.0846915920261 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 4.77555E-04
A/V 8707 Ig-72 65 rs773760649 0.0771 0.006 None N 0.199 0.023 0.0846915920261 gnomAD-4.0.0 4.95808E-06 None None None None N None 0 0 None 0 0 None 0 0 5.08617E-06 0 3.20205E-05
P/A 8801 Ig-73 66 rs1220132171 0.0594 -0.26 None N 0.106 0.053 0.0666544352282 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
P/A 8801 Ig-73 66 rs1220132171 0.0594 -0.26 None N 0.106 0.053 0.0666544352282 gnomAD-4.0.0 3.18267E-06 None None None None I None 0 2.28655E-05 None 0 0 None 0 0 2.85848E-06 0 0
P/L 8801 Ig-73 66 rs778967914 0.0702 -0.145 None N 0.207 0.106 0.244539031024 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
P/L 8801 Ig-73 66 rs778967914 0.0702 -0.145 None N 0.207 0.106 0.244539031024 gnomAD-4.0.0 4.10536E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.95668E-05 0
P/T 8801 Ig-73 66 None 0.0657 None None N 0.096 0.062 0.104622674875 gnomAD-4.0.0 3.18267E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.86566E-05 0
P/L 8894 Ig-74 65 rs13398235 0.0768 -0.058 0.066 N 0.251 0.156 None gnomAD-2.1.1 7.73921E-02 None None None None N None 1.52777E-01 1.89708E-01 None 4.07808E-02 2.8946E-02 None 1.67201E-01 None 5.70628E-02 2.62172E-02 5.85181E-02
P/L 8894 Ig-74 65 rs13398235 0.0768 -0.058 0.066 N 0.251 0.156 None gnomAD-3.1.2 7.94563E-02 None None None None N None 1.52098E-01 1.45151E-01 4.28571E-02 3.57555E-02 2.62346E-02 None 5.84514E-02 4.74684E-02 2.51735E-02 1.62375E-01 6.89655E-02
P/L 8894 Ig-74 65 rs13398235 0.0768 -0.058 0.066 N 0.251 0.156 None 1000 genomes 1.11422E-01 None None None None N None 1.649E-01 1.527E-01 None None 2.58E-02 3.58E-02 None None None 1.759E-01 None
P/L 8894 Ig-74 65 rs13398235 0.0768 -0.058 0.066 N 0.251 0.156 None gnomAD-4.0.0 4.72529E-02 None None None None N None 1.55864E-01 1.77094E-01 None 3.94959E-02 1.50529E-02 None 5.88907E-02 4.19142E-02 2.56292E-02 1.59453E-01 5.26341E-02
E/K 8990 Ig-75 65 None 0.0775 None None N 0.116 0.09 0.186928172975 gnomAD-4.0.0 1.59139E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85843E-06 0 0
T/A 9083 Ig-76 65 None 0.0607 None 0.001 N 0.086 0.022 0.0401082797425 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 9083 Ig-76 65 None 0.0742 None 0.002 N 0.212 0.04 0.117506650769 gnomAD-4.0.0 1.5913E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02407E-05
I/T 9269 Ig-78 65 rs2076732210 0.0748 None None N 0.159 0.128 0.0884992946249 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
I/T 9269 Ig-78 65 rs2076732210 0.0748 None None N 0.159 0.128 0.0884992946249 gnomAD-4.0.0 6.56953E-06 None None None None I None 0 6.54879E-05 None 0 0 None 0 0 0 0 0
I/V 9269 Ig-78 65 rs766951571 0.0636 -0.269 None N 0.117 0.085 0.126345400529 gnomAD-2.1.1 1.43E-05 None None None None I None 0 0 None 0 5.12E-05 None 6.54E-05 None 0 7.8E-06 0
I/V 9269 Ig-78 65 rs766951571 0.0636 -0.269 None N 0.117 0.085 0.126345400529 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 9269 Ig-78 65 rs766951571 0.0636 -0.269 None N 0.117 0.085 0.126345400529 gnomAD-4.0.0 1.53726E-05 None None None None I None 0 0 None 0 2.42389E-05 None 0 0 7.1793E-06 1.07227E-04 0
R/G 9365 Ig-79 65 None 0.1232 None 0.579 None 0.384 0.147 0.294561560033 gnomAD-4.0.0 1.36839E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79892E-06 0 0
R/P 9365 Ig-79 65 None 0.1976 None 0.907 None 0.389 0.243 0.222439326576 gnomAD-4.0.0 6.84204E-07 None None None None I None 0 0 None 0 2.51889E-05 None 0 0 0 0 0
R/Q 9365 Ig-79 65 rs570608843 0.0804 0.142 0.039 None 0.307 0.108 0.0611884634855 gnomAD-2.1.1 4.28E-05 None None None None I None 0 1.97986E-04 None 9.67E-05 0 None 0 None 0 3.12E-05 0
R/Q 9365 Ig-79 65 rs570608843 0.0804 0.142 0.039 None 0.307 0.108 0.0611884634855 gnomAD-3.1.2 4.6E-05 None None None None I None 0 6.55E-05 0 0 0 None 0 0 8.82E-05 0 0
R/Q 9365 Ig-79 65 rs570608843 0.0804 0.142 0.039 None 0.307 0.108 0.0611884634855 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
R/Q 9365 Ig-79 65 rs570608843 0.0804 0.142 0.039 None 0.307 0.108 0.0611884634855 gnomAD-4.0.0 7.18818E-05 None None None None I None 2.66596E-05 1.16674E-04 None 0 0 None 0 0 8.90009E-05 2.19635E-05 0
R/W 9365 Ig-79 65 rs190600127 0.1297 -0.481 0.022 None 0.319 0.248 None gnomAD-2.1.1 1.32653E-04 None None None None I None 6.46E-05 3.76615E-04 None 0 0 None 4.57636E-04 None 0 2.66E-05 3.31565E-04
R/W 9365 Ig-79 65 rs190600127 0.1297 -0.481 0.022 None 0.319 0.248 None gnomAD-3.1.2 6.57E-05 None None None None I None 2.41E-05 3.27697E-04 0 0 0 None 0 0 4.41E-05 0 4.77555E-04
R/W 9365 Ig-79 65 rs190600127 0.1297 -0.481 0.022 None 0.319 0.248 None 1000 genomes 3.99361E-04 None None None None I None 0 1.4E-03 None None 0 1E-03 None None None 0 None
R/W 9365 Ig-79 65 rs190600127 0.1297 -0.481 0.022 None 0.319 0.248 None gnomAD-4.0.0 4.77129E-05 None None None None I None 6.66418E-05 4.5E-04 None 0 0 None 0 0 1.18666E-05 2.30617E-04 1.60036E-04
K/E 9461 Ig-80 65 None 0.2156 None 0.811 None 0.414 0.164 0.231873229951 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
M/I 9558 Ig-81 66 rs868771235 0.1778 None 0.028 None 0.172 0.127 0.228597637076 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
M/V 9558 Ig-81 66 None 0.0786 None 0.001 None 0.075 0.104 0.130388298395 gnomAD-4.0.0 1.59111E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85806E-06 0 0
K/E 9763 Ig-83 66 rs1414221406 0.8232 None 0.996 None 0.483 0.295 0.244539031024 gnomAD-4.0.0 1.59099E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8578E-06 0 0
K/N 9763 Ig-83 66 rs1301356747 0.9503 0.526 0.999 None 0.607 0.197 0.117506650769 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.85E-06 0
K/N 9763 Ig-83 66 rs1301356747 0.9503 0.526 0.999 None 0.607 0.197 0.117506650769 gnomAD-4.0.0 3.18214E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85801E-06 0 3.02352E-05
L/F 9965 Ig-84 66 None 0.2063 None 0.56 None 0.227 0.115 0.38225645794 gnomAD-4.0.0 8.40227E-06 None None None None N None 0 0 None 0 0 None 0 0 9.18753E-06 0 0
A/G 10052 Ig-85 64 None 0.3054 None 0.425 None 0.291 0.205 0.134241683229 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/T 10052 Ig-85 64 rs746145079 0.1587 -0.759 0.01 None 0.083 0.08 0.0920862733494 gnomAD-2.1.1 8.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
A/T 10052 Ig-85 64 rs746145079 0.1587 -0.759 0.01 None 0.083 0.08 0.0920862733494 gnomAD-4.0.0 4.10488E-06 None None None None N None 0 0 None 0 0 None 0 1.7337E-04 3.59761E-06 0 1.65634E-05
P/A 10141 Ig-86 64 None 0.1433 None 0.001 None 0.123 0.097 0.0884992946249 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/F 13750 Ig-87 67 None 0.3107 None 1.0 N 0.61 0.338 0.493494165309 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/S 13939 Ig-89 64 None 0.4562 None 1.0 N 0.819 0.343 0.209622950755 gnomAD-4.0.0 1.6204E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.46297E-05 0
L/M 14028 Ig-90 64 rs777098368 0.2493 None 0.993 N 0.613 0.135 0.289098819767 gnomAD-4.0.0 6.84567E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99763E-07 0 0
F/L 14116 Ig-91 63 None 0.9559 None 0.999 N 0.461 0.365 0.21737058555 gnomAD-4.0.0 1.59277E-06 None None None None I None 0 0 None 0 2.78164E-05 None 0 0 0 0 0
L/V 14205 Ig-92 64 rs747480084 0.1955 -0.353 0.201 N 0.385 0.046 0.293147016451 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
L/V 14205 Ig-92 64 rs747480084 0.1955 -0.353 0.201 N 0.385 0.046 0.293147016451 gnomAD-4.0.0 1.36869E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79921E-06 0 0
L/I 14293 Ig-93 63 None 0.0791 None 0.213 N 0.218 0.03 0.104622674875 gnomAD-4.0.0 1.59237E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43295E-05 0
L/Q 14382 Ig-94 64 None 0.1933 None 0.988 D 0.641 0.457 0.575880570741 gnomAD-4.0.0 1.59257E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86074E-06 0 0
I/V 14560 Ig-96 64 rs2059893136 0.0764 None 0.001 N 0.18 0.174 0.278143212241 gnomAD-4.0.0 4.80815E-06 None None None None N None 0 0 None 0 0 None 0 0 5.41023E-06 1.17448E-05 0
K/N 14649 Ig-97 64 None 0.6362 None 0.998 N 0.415 0.206 0.190952846119 gnomAD-4.0.0 6.84385E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99593E-07 0 0
L/V 14738 Ig-98 64 rs2154219916 0.1435 None 0.067 N 0.229 0.047 0.233150807113 gnomAD-4.0.0 6.84516E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99735E-07 0 0
L/I 14827 Ig-99 63 None 0.122 None 0.999 N 0.395 0.134 0.29527378943 gnomAD-4.0.0 1.62002E-06 None None None None I None 0 0 None 0 2.83624E-05 None 0 0 0 0 0
P/L 14916 Ig-100 64 None 0.1007 None 0.002 N 0.236 0.138 0.261217442401 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
P/S 14916 Ig-100 64 rs2058747129 0.1177 None 0.891 N 0.309 0.182 0.117506650769 gnomAD-4.0.0 3.18692E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72485E-06 0 0
L/P 15005 Ig-101 64 rs369992659 0.1491 -0.318 0.963 N 0.347 0.468 None gnomAD-2.1.1 3.23E-05 None None None None I None 3.31263E-04 0 None 0 0 None 0 None 0 7.84E-06 0
L/P 15005 Ig-101 64 rs369992659 0.1491 -0.318 0.963 N 0.347 0.468 None gnomAD-3.1.2 1.25016E-04 None None None None I None 4.34468E-04 0 0 0 0 None 0 0 1.47E-05 0 0
L/P 15005 Ig-101 64 rs369992659 0.1491 -0.318 0.963 N 0.347 0.468 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
L/P 15005 Ig-101 64 rs369992659 0.1491 -0.318 0.963 N 0.347 0.468 None gnomAD-4.0.0 1.73674E-05 None None None None I None 3.20239E-04 0 None 0 0 None 1.56367E-05 0 8.48176E-07 0 3.20605E-05
L/F 15094 Ig-102 64 None 0.1329 None 0.934 D 0.249 0.394 0.701127891572 gnomAD-4.0.0 1.59388E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43332E-05 0
L/I 15094 Ig-102 64 rs1281104886 0.077 -0.585 0.669 D 0.236 0.341 0.552367828057 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66279E-04
L/I 15094 Ig-102 64 rs1281104886 0.077 -0.585 0.669 D 0.236 0.341 0.552367828057 gnomAD-3.1.2 6.59E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
L/I 15094 Ig-102 64 rs1281104886 0.077 -0.585 0.669 D 0.236 0.341 0.552367828057 gnomAD-4.0.0 3.84945E-06 None None None None N None 1.69205E-05 0 None 0 0 None 0 0 0 0 5.69606E-05
L/V 15094 Ig-102 64 rs1281104886 0.0858 None 0.454 N 0.243 0.328 0.534093007224 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/V 15094 Ig-102 64 rs1281104886 0.0858 None 0.454 N 0.243 0.328 0.534093007224 gnomAD-4.0.0 6.58701E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47297E-05 0 0
L/V 15183 Ig-103 64 None 0.1184 None 0.046 N 0.262 0.039 0.20549828249 gnomAD-4.0.0 1.59365E-06 None None None None I None 0 0 None 0 2.78878E-05 None 0 0 0 0 0
P/S 15543 Ig-107 64 None 0.3425 None 1.0 D 0.686 0.547 0.557405679382 gnomAD-4.0.0 1.59436E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86441E-06 0 0
P/T 15543 Ig-107 64 None 0.3165 None 0.999 D 0.651 0.502 0.584148673918 gnomAD-4.0.0 1.59436E-06 None None None None N None 0 0 None 0 2.78056E-05 None 0 0 0 0 0
K/R 15629 Ig-108 62 rs774914362 0.0848 0.303 0.505 N 0.383 0.105 0.252681307341 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
R/C 16027 Ig-109 60 rs765032242 0.5134 0.028 1.0 D 0.767 0.456 0.520002024791 gnomAD-2.1.1 2.87E-05 None None None None N None 0 2.83E-05 None 0 0 None 6.54E-05 None 0 3.93E-05 0
R/C 16027 Ig-109 60 rs765032242 0.5134 0.028 1.0 D 0.767 0.456 0.520002024791 gnomAD-3.1.2 1.98E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 2.95E-05 0 0
R/C 16027 Ig-109 60 rs765032242 0.5134 0.028 1.0 D 0.767 0.456 0.520002024791 gnomAD-4.0.0 1.42637E-05 None None None None N None 1.33715E-05 3.33957E-05 None 0 0 None 0 0 1.44172E-05 3.29525E-05 0
R/H 16027 Ig-109 60 rs757013471 0.2933 -0.699 1.0 D 0.751 0.453 0.296329037015 gnomAD-2.1.1 5.73E-05 None None None None N None 4.14E-05 8.5E-05 None 0 0 None 3.59524E-04 None 0 7.86E-06 0
R/H 16027 Ig-109 60 rs757013471 0.2933 -0.699 1.0 D 0.751 0.453 0.296329037015 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/H 16027 Ig-109 60 rs757013471 0.2933 -0.699 1.0 D 0.751 0.453 0.296329037015 gnomAD-4.0.0 1.86038E-05 None None None None N None 2.67315E-05 5.00818E-05 None 0 0 None 0 0 2.54416E-06 2.30632E-04 1.60272E-05
R/I 16323 Ig-110 62 None 0.9704 None 1.0 N 0.735 0.431 0.526842377483 gnomAD-4.0.0 1.59405E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86241E-06 0 0
R/C 17019 Ig-111 65 rs773394284 0.136 -0.299 0.964 D 0.318 0.324 0.455722563999 gnomAD-2.1.1 3.62E-05 None None None None N None 0 8.71E-05 None 0 5.61E-05 None 1.30762E-04 None 0 8.89E-06 0
R/C 17019 Ig-111 65 rs773394284 0.136 -0.299 0.964 D 0.318 0.324 0.455722563999 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/C 17019 Ig-111 65 rs773394284 0.136 -0.299 0.964 D 0.318 0.324 0.455722563999 gnomAD-4.0.0 1.7363E-05 None None None None N None 0 5.00567E-05 None 0 0 None 0 0 1.78089E-05 3.29583E-05 1.60251E-05
R/H 17019 Ig-111 65 rs765642042 0.065 -1.185 None N 0.094 0.097 0.0297737177859 gnomAD-2.1.1 1.61E-05 None None None None N None 0 2.9E-05 None 0 0 None 3.27E-05 None 0 1.78E-05 0
R/H 17019 Ig-111 65 rs765642042 0.065 -1.185 None N 0.094 0.097 0.0297737177859 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
R/H 17019 Ig-111 65 rs765642042 0.065 -1.185 None N 0.094 0.097 0.0297737177859 gnomAD-4.0.0 1.17816E-05 None None None None N None 0 3.33667E-05 None 0 0 None 0 0 1.18724E-05 1.09837E-05 3.20492E-05
R/L 17341 Ig-112 91 rs370390570 0.8718 0.79 0.991 N 0.478 0.425 0.416956310301 gnomAD-2.1.1 8.63E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.89E-05 0
R/L 17341 Ig-112 91 rs370390570 0.8718 0.79 0.991 N 0.478 0.425 0.416956310301 gnomAD-4.0.0 2.77426E-06 None None None None N None 0 0 None 0 0 None 0 0 2.72097E-06 1.22043E-05 0
R/Q 17341 Ig-112 91 rs370390570 0.7826 0.45 1.0 N 0.509 0.288 None gnomAD-2.1.1 1.25401E-04 None None None None N None 7.52383E-04 5.95E-05 None 0 4.75436E-04 None 0 None 0 3.3E-05 0
R/Q 17341 Ig-112 91 rs370390570 0.7826 0.45 1.0 N 0.509 0.288 None gnomAD-3.1.2 3.75163E-04 None None None None N None 1.25592E-03 1.97006E-04 0 0 1.9478E-04 None 0 0 1.47E-05 0 0
R/Q 17341 Ig-112 91 rs370390570 0.7826 0.45 1.0 N 0.509 0.288 None 1000 genomes 3.99361E-04 None None None None N None 1.5E-03 0 None None 0 0 None None None 0 None
R/Q 17341 Ig-112 91 rs370390570 0.7826 0.45 1.0 N 0.509 0.288 None gnomAD-4.0.0 8.09345E-05 None None None None N None 1.17049E-03 1.54682E-04 None 0 2.47491E-04 None 0 1.67448E-04 1.45239E-05 0 6.49308E-05
R/G 17736 Ig-113 60 rs571702144 0.9896 -0.097 1.0 N 0.602 0.477 0.426084969639 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
R/G 17736 Ig-113 60 rs571702144 0.9896 -0.097 1.0 N 0.602 0.477 0.426084969639 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
R/G 17736 Ig-113 60 rs571702144 0.9896 -0.097 1.0 N 0.602 0.477 0.426084969639 1000 genomes 1.99681E-04 None None None None I None 0 1.4E-03 None None 0 0 None None None 0 None
R/G 17736 Ig-113 60 rs571702144 0.9896 -0.097 1.0 N 0.602 0.477 0.426084969639 gnomAD-4.0.0 6.57834E-06 None None None None I None 0 6.55136E-05 None 0 0 None 0 0 0 0 0
R/Q 17736 Ig-113 60 rs766817830 0.7624 0.599 1.0 N 0.706 0.344 0.165133752707 gnomAD-2.1.1 6.84E-05 None None None None I None 0 1.15935E-04 None 9.95E-05 0 None 2.61455E-04 None 0 2.67E-05 1.65563E-04
R/Q 17736 Ig-113 60 rs766817830 0.7624 0.599 1.0 N 0.706 0.344 0.165133752707 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 2.88184E-04 0 None 0 0 1.47E-05 0 0
R/Q 17736 Ig-113 60 rs766817830 0.7624 0.599 1.0 N 0.706 0.344 0.165133752707 gnomAD-4.0.0 2.66565E-05 None None None None I None 0 8.33861E-05 None 1.35217E-04 0 None 0 3.29164E-04 1.27181E-05 1.64719E-04 3.20431E-05
R/Q 18037 Ig-114 70 rs541688627 0.6603 0.274 1.0 N 0.676 0.361 0.176091768786 gnomAD-2.1.1 2.02E-05 None None None None N None 0 2.9E-05 None 0 0 None 6.55E-05 None 0 8.94E-06 1.66445E-04
R/Q 18037 Ig-114 70 rs541688627 0.6603 0.274 1.0 N 0.676 0.361 0.176091768786 gnomAD-3.1.2 6.58E-05 None None None None N None 4.83E-05 5.25279E-04 0 0 0 None 0 0 0 0 0
R/Q 18037 Ig-114 70 rs541688627 0.6603 0.274 1.0 N 0.676 0.361 0.176091768786 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
R/Q 18037 Ig-114 70 rs541688627 0.6603 0.274 1.0 N 0.676 0.361 0.176091768786 gnomAD-4.0.0 1.79846E-05 None None None None N None 4.00427E-05 2.16898E-04 None 0 0 None 0 0 7.6332E-06 3.29801E-05 1.60185E-05
R/W 18037 Ig-114 70 rs201623791 0.8369 -0.266 1.0 N 0.759 0.374 None gnomAD-2.1.1 5.73E-05 None None None None N None 1.24213E-04 2.83E-05 None 0 0 None 3.27E-05 None 0 8.64E-05 0
R/W 18037 Ig-114 70 rs201623791 0.8369 -0.266 1.0 N 0.759 0.374 None gnomAD-3.1.2 7.9E-05 None None None None N None 1.44949E-04 6.57E-05 0 0 0 None 0 0 7.36E-05 0 0
R/W 18037 Ig-114 70 rs201623791 0.8369 -0.266 1.0 N 0.759 0.374 None gnomAD-4.0.0 1.10395E-04 None None None None N None 9.35954E-05 5.00734E-05 None 0 0 None 0 0 1.34002E-04 1.09914E-05 1.44231E-04
R/L 18451 Ig-115 70 None 0.7689 None 1.0 N 0.614 0.416 0.348324211639 gnomAD-4.0.0 6.86275E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00531E-07 0 0
R/Q 18451 Ig-115 70 rs755767286 0.4295 0.348 1.0 N 0.733 0.333 0.240491677333 gnomAD-2.1.1 2.87E-05 None None None None N None 0 0 None 0 0 None 1.69584E-04 None 0 1.8E-05 0
R/Q 18451 Ig-115 70 rs755767286 0.4295 0.348 1.0 N 0.733 0.333 0.240491677333 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 9.44E-05 0 1.47E-05 0 0
R/Q 18451 Ig-115 70 rs755767286 0.4295 0.348 1.0 N 0.733 0.333 0.240491677333 gnomAD-4.0.0 2.05083E-05 None None None None N None 0 0 None 0 0 None 1.56769E-05 0 1.52746E-05 1.33749E-04 3.21213E-05
R/G 18756 Ig-116 69 None 0.9362 None 1.0 N 0.604 0.346 0.348101942276 gnomAD-4.0.0 1.59387E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02792E-05
R/K 18756 Ig-116 69 rs1440402638 0.355 -0.194 0.997 N 0.487 0.313 0.280181792013 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
R/K 18756 Ig-116 69 rs1440402638 0.355 -0.194 0.997 N 0.487 0.313 0.280181792013 gnomAD-4.0.0 3.18827E-06 None None None None N None 0 0 None 0 0 None 0 0 5.7259E-06 0 0
R/T 18756 Ig-116 69 None 0.9518 None 1.0 N 0.632 0.504 0.314417295294 gnomAD-4.0.0 3.18827E-06 None None None None N None 0 0 None 0 2.77685E-05 None 0 0 2.86295E-06 0 0
R/K 19155 Ig-117 61 rs72646833 0.6029 0.022 0.997 N 0.545 0.26 None gnomAD-2.1.1 2.04058E-03 None None None None I None 2.17877E-02 7.65567E-04 None 0 0 None 3.27E-05 None 0 5.49E-05 1.12644E-03
R/K 19155 Ig-117 61 rs72646833 0.6029 0.022 0.997 N 0.545 0.26 None gnomAD-3.1.2 6.33353E-03 None None None None I None 2.24277E-02 1.37525E-03 0 0 0 None 0 0 1.17675E-04 2.06954E-04 1.91571E-03
R/K 19155 Ig-117 61 rs72646833 0.6029 0.022 0.997 N 0.545 0.26 None 1000 genomes 5.39137E-03 None None None None I None 2.04E-02 0 None None 0 0 None None None 0 None
R/K 19155 Ig-117 61 rs72646833 0.6029 0.022 0.997 N 0.545 0.26 None gnomAD-4.0.0 1.18339E-03 None None None None I None 2.30976E-02 1.11756E-03 None 0 0 None 0 6.60939E-04 1.86518E-05 7.6864E-05 1.23318E-03
R/C 19451 Ig-118 61 rs763871350 0.8061 -0.1 1.0 N 0.743 0.459 None gnomAD-2.1.1 4.02E-05 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 6.23E-05 3.31455E-04
R/C 19451 Ig-118 61 rs763871350 0.8061 -0.1 1.0 N 0.743 0.459 None gnomAD-3.1.2 2.63E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 4.41E-05 0 0
R/C 19451 Ig-118 61 rs763871350 0.8061 -0.1 1.0 N 0.743 0.459 None gnomAD-4.0.0 4.27677E-05 None None None None N None 1.33536E-05 1.66795E-05 None 0 0 None 0 1.64474E-04 5.4254E-05 0 3.20287E-05
R/H 19451 Ig-118 61 rs760068789 0.6617 -0.774 1.0 N 0.761 0.419 0.270447802918 gnomAD-2.1.1 1.21E-05 None None None None N None 6.46E-05 2.9E-05 None 0 0 None 3.27E-05 None 0 0 0
R/H 19451 Ig-118 61 rs760068789 0.6617 -0.774 1.0 N 0.761 0.419 0.270447802918 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/H 19451 Ig-118 61 rs760068789 0.6617 -0.774 1.0 N 0.761 0.419 0.270447802918 gnomAD-4.0.0 8.67753E-06 None None None None N None 1.33547E-05 1.66795E-05 None 0 0 None 0 0 7.62949E-06 3.29395E-05 0
H/Q 19849 Ig-119 60 None 0.2467 None 0.642 N 0.258 0.093 0.0954503805726 gnomAD-4.0.0 1.5919E-06 None None None None I None 0 0 None 0 2.77624E-05 None 0 0 0 0 0
R/Q 20836 Ig-122 68 rs201693851 0.7812 0.135 1.0 N 0.719 0.381 None gnomAD-2.1.1 1.03579E-04 None None None None N None 8.27E-05 2.83E-05 None 0 0 None 0 None 0 2.03182E-04 0
R/Q 20836 Ig-122 68 rs201693851 0.7812 0.135 1.0 N 0.719 0.381 None gnomAD-3.1.2 1.11801E-04 None None None None N None 7.24E-05 6.55E-05 0 0 0 None 0 0 1.91261E-04 0 0
R/Q 20836 Ig-122 68 rs201693851 0.7812 0.135 1.0 N 0.719 0.381 None gnomAD-4.0.0 2.62804E-04 None None None None N None 1.06823E-04 3.33533E-05 None 0 0 None 1.56216E-05 0 3.44179E-04 0 1.12093E-04
R/C 21238 Ig-123 62 rs190432620 0.7639 -0.03 1.0 D 0.731 0.384 None gnomAD-2.1.1 2.02E-05 None None None None I None 6.48E-05 0 None 0 0 None 6.55E-05 None 0 8.93E-06 1.67168E-04
R/C 21238 Ig-123 62 rs190432620 0.7639 -0.03 1.0 D 0.731 0.384 None gnomAD-3.1.2 2.63E-05 None None None None I None 2.42E-05 0 0 0 0 None 0 0 4.41E-05 0 0
R/C 21238 Ig-123 62 rs190432620 0.7639 -0.03 1.0 D 0.731 0.384 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
R/C 21238 Ig-123 62 rs190432620 0.7639 -0.03 1.0 D 0.731 0.384 None gnomAD-4.0.0 1.11632E-05 None None None None I None 1.33461E-05 0 None 0 2.24376E-05 None 0 0 1.01755E-05 4.39454E-05 0
R/H 21238 Ig-123 62 rs544396866 0.5617 -0.612 1.0 N 0.757 0.409 0.398581233421 gnomAD-2.1.1 1.79E-05 None None None None I None 0 0 None 0 0 None 1.3101E-04 None 0 0 1.41363E-04
R/H 21238 Ig-123 62 rs544396866 0.5617 -0.612 1.0 N 0.757 0.409 0.398581233421 gnomAD-3.1.2 2.63E-05 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 6.20861E-04 0
R/H 21238 Ig-123 62 rs544396866 0.5617 -0.612 1.0 N 0.757 0.409 0.398581233421 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
R/H 21238 Ig-123 62 rs544396866 0.5617 -0.612 1.0 N 0.757 0.409 0.398581233421 gnomAD-4.0.0 1.17827E-05 None None None None I None 1.33415E-05 0 None 0 0 None 0 0 5.08767E-06 1.31842E-04 0
R/L 21238 Ig-123 62 rs544396866 0.9092 0.466 1.0 N 0.605 0.433 0.283761946502 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 0 0
R/L 21238 Ig-123 62 rs544396866 0.9092 0.466 1.0 N 0.605 0.433 0.283761946502 gnomAD-4.0.0 6.84728E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.16023E-05 0
R/Q 21928 Ig-125 63 rs769057462 0.5813 0.263 1.0 N 0.691 0.299 None gnomAD-2.1.1 1.63E-05 None None None None N None 0 0 None 1.00442E-04 5.71E-05 None 0 None 0 1.8E-05 0
R/Q 21928 Ig-125 63 rs769057462 0.5813 0.263 1.0 N 0.691 0.299 None gnomAD-3.1.2 3.29E-05 None None None None N None 2.41E-05 6.55E-05 0 0 0 None 0 0 4.41E-05 0 0
R/Q 21928 Ig-125 63 rs769057462 0.5813 0.263 1.0 N 0.691 0.299 None gnomAD-4.0.0 2.30393E-05 None None None None N None 2.67917E-05 5.03761E-05 None 3.40344E-05 2.25002E-05 None 0 1.65563E-04 2.38219E-05 1.1148E-05 0
R/W 21928 Ig-125 63 rs371856109 0.8753 -0.356 1.0 N 0.755 0.472 None gnomAD-2.1.1 5.78E-05 None None None None N None 1.24854E-04 8.61E-05 None 0 0 None 3.32E-05 None 0 5.53E-05 2.84172E-04
R/W 21928 Ig-125 63 rs371856109 0.8753 -0.356 1.0 N 0.755 0.472 None gnomAD-3.1.2 3.95E-05 None None None None N None 9.66E-05 0 0 0 0 None 0 0 2.94E-05 0 0
R/W 21928 Ig-125 63 rs371856109 0.8753 -0.356 1.0 N 0.755 0.472 None gnomAD-4.0.0 6.7836E-05 None None None None N None 8.03514E-05 8.39123E-05 None 0 0 None 0 0 8.07879E-05 2.22559E-05 1.60901E-05
K/Q 22326 Ig-126 62 None 0.5198 None 0.822 N 0.425 0.142 0.126345400529 gnomAD-4.0.0 1.59239E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86043E-06 0 0
K/R 22326 Ig-126 62 rs202125813 0.0717 0.149 0.006 N 0.223 0.055 None gnomAD-2.1.1 4.93463E-04 None None None None I None 5.24967E-03 2.54626E-04 None 0 0 None 0 None 0 7.83E-06 1.40607E-04
K/R 22326 Ig-126 62 rs202125813 0.0717 0.149 0.006 N 0.223 0.055 None gnomAD-3.1.2 1.63049E-03 None None None None I None 5.66784E-03 7.20555E-04 0 0 0 None 0 0 1.47E-05 0 4.78469E-04
K/R 22326 Ig-126 62 rs202125813 0.0717 0.149 0.006 N 0.223 0.055 None 1000 genomes 9.98403E-04 None None None None I None 3.8E-03 0 None None 0 0 None None None 0 None
K/R 22326 Ig-126 62 rs202125813 0.0717 0.149 0.006 N 0.223 0.055 None gnomAD-4.0.0 3.01865E-04 None None None None I None 5.73165E-03 4.33348E-04 None 0 0 None 0 1.6518E-04 9.32627E-06 0 3.04253E-04
K/I 22615 Ig-127 56 rs372296363 0.696 0.715 0.998 N 0.601 0.478 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
K/I 22615 Ig-127 56 rs372296363 0.696 0.715 0.998 N 0.601 0.478 None gnomAD-4.0.0 9.55098E-06 None None None None N None 0 0 None 0 0 None 0 0 1.42976E-05 0 3.0259E-05
R/K 23012 Ig-128 63 None 0.3697 None 0.997 N 0.543 0.274 0.187945064343 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
R/K 23407 Ig-129 63 rs1417805989 0.3901 0.303 0.025 N 0.387 0.14 0.208000267992 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
R/K 23407 Ig-129 63 rs1417805989 0.3901 0.303 0.025 N 0.387 0.14 0.208000267992 gnomAD-4.0.0 3.18337E-06 None None None None I None 0 4.57331E-05 None 0 0 None 0 0 0 0 0
R/I 24491 Ig-132 61 None 0.953 None 1.0 N 0.725 0.433 0.361758802978 gnomAD-4.0.0 2.0536E-06 None None None None I None 0 0 None 0 0 None 0 1.73792E-04 0 2.32099E-05 0
R/T 24491 Ig-132 61 None 0.9848 None 1.0 N 0.65 0.395 0.294561560033 gnomAD-4.0.0 6.84533E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99794E-07 0 0
R/Q 24780 Ig-133 65 rs776673912 0.1039 0.116 0.994 N 0.407 0.246 0.193865811164 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 9.81E-05 None 0 0 1.66168E-04
R/Q 24780 Ig-133 65 rs776673912 0.1039 0.116 0.994 N 0.407 0.246 0.193865811164 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
R/Q 24780 Ig-133 65 rs776673912 0.1039 0.116 0.994 N 0.407 0.246 0.193865811164 gnomAD-4.0.0 8.67764E-06 None None None None I None 0 1.66744E-05 None 0 0 None 0 0 5.08647E-06 5.49282E-05 3.20307E-05
R/C 25176 Ig-134 66 rs368339903 0.5673 -0.22 1.0 N 0.733 0.394 None gnomAD-2.1.1 6.79E-05 None None None None I None 8.27E-05 3.96511E-04 None 0 0 None 0 None 4E-05 1.56E-05 0
R/C 25176 Ig-134 66 rs368339903 0.5673 -0.22 1.0 N 0.733 0.394 None gnomAD-3.1.2 1.32E-05 None None None None I None 0 1.31199E-04 0 0 0 None 0 0 0 0 0
R/C 25176 Ig-134 66 rs368339903 0.5673 -0.22 1.0 N 0.733 0.394 None gnomAD-4.0.0 2.04554E-05 None None None None I None 4.00823E-05 2.83598E-04 None 0 0 None 0 0 6.78185E-06 2.19606E-05 4.80477E-05
R/H 25176 Ig-134 66 rs375693396 0.503 -1.14 1.0 N 0.687 0.349 None gnomAD-2.1.1 1.03669E-04 None None None None I None 4.13E-05 2.26603E-04 None 0 0 None 0 None 0 1.33033E-04 4.21941E-04
R/H 25176 Ig-134 66 rs375693396 0.503 -1.14 1.0 N 0.687 0.349 None gnomAD-3.1.2 1.3153E-04 None None None None I None 2.41E-05 3.27955E-04 0 0 0 None 0 0 1.9121E-04 0 4.78927E-04
R/H 25176 Ig-134 66 rs375693396 0.503 -1.14 1.0 N 0.687 0.349 None 1000 genomes 1.99681E-04 None None None None I None 0 1.4E-03 None None 0 0 None None None 0 None
R/H 25176 Ig-134 66 rs375693396 0.503 -1.14 1.0 N 0.687 0.349 None gnomAD-4.0.0 1.20862E-04 None None None None I None 1.33351E-05 2.33458E-04 None 0 0 None 0 1.65235E-04 1.45812E-04 0 1.12068E-04
R/S 25176 Ig-134 66 None 0.9547 None 1.0 N 0.594 0.421 0.289474373501 gnomAD-4.0.0 6.84347E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9958E-07 0 0
R/L 25573 Ig-135 60 rs760052770 0.8828 None 1.0 N 0.605 0.39 0.32580497728 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/L 25573 Ig-135 60 rs760052770 0.8828 None 1.0 N 0.605 0.39 0.32580497728 gnomAD-4.0.0 6.57609E-06 None None None None I None 2.41336E-05 0 None 0 0 None 0 0 0 0 0
R/Q 25573 Ig-135 60 rs760052770 0.5476 0.325 1.0 N 0.718 0.326 0.211220785272 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 1.78E-05 0
R/Q 25573 Ig-135 60 rs760052770 0.5476 0.325 1.0 N 0.718 0.326 0.211220785272 gnomAD-3.1.2 3.29E-05 None None None None I None 4.83E-05 0 0 0 3.86997E-04 None 0 0 1.47E-05 0 0
R/Q 25573 Ig-135 60 rs760052770 0.5476 0.325 1.0 N 0.718 0.326 0.211220785272 gnomAD-4.0.0 1.85967E-05 None None None None I None 2.67101E-05 0 None 0 3.5727E-04 None 0 0 8.47761E-06 0 3.20359E-05
K/M 25862 Ig-136 65 rs1410859942 0.4294 0.25 1.0 N 0.413 0.341 0.302793454619 gnomAD-2.1.1 7.16E-06 None None None None N None 0 0 None 0 0 None 0 None 0 7.86E-06 1.40766E-04
K/M 25862 Ig-136 65 rs1410859942 0.4294 0.25 1.0 N 0.413 0.341 0.302793454619 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/M 25862 Ig-136 65 rs1410859942 0.4294 0.25 1.0 N 0.413 0.341 0.302793454619 gnomAD-4.0.0 3.84481E-06 None None None None N None 0 0 None 0 0 None 0 0 2.39407E-06 0 5.69217E-05
K/N 25862 Ig-136 65 rs747449030 0.8059 None 0.98 N 0.376 0.264 0.233150807113 gnomAD-4.0.0 4.79036E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29727E-06 0 0
K/R 25862 Ig-136 65 None 0.077 None 0.031 N 0.201 0.11 0.241078983079 gnomAD-4.0.0 1.59193E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85964E-06 0 0
R/I 26655 Ig-138 62 None 0.9275 None 0.97 N 0.523 0.335 0.353974658523 gnomAD-4.0.0 6.84258E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99533E-07 0 0
R/K 26655 Ig-138 62 rs1186804740 0.3979 0.353 0.025 N 0.241 0.09 0.218112801441 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
R/K 26655 Ig-138 62 rs1186804740 0.3979 0.353 0.025 N 0.241 0.09 0.218112801441 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/K 26655 Ig-138 62 rs1186804740 0.3979 0.353 0.025 N 0.241 0.09 0.218112801441 gnomAD-4.0.0 1.23948E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69533E-06 0 0
K/E 26944 Ig-139 65 rs1199099522 0.2789 0.414 0.892 N 0.428 0.252 0.301455362545 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/E 26944 Ig-139 65 rs1199099522 0.2789 0.414 0.892 N 0.428 0.252 0.301455362545 gnomAD-4.0.0 3.1831E-06 None None None None N None 0 4.5731E-05 None 0 0 None 0 0 0 0 0
R/Q 27341 Ig-140 64 rs555414240 0.3428 0.088 1.0 N 0.698 0.358 None gnomAD-2.1.1 2.82E-05 None None None None I None 0 0 None 0 1.11321E-04 None 0 None 0 4.46E-05 0
R/Q 27341 Ig-140 64 rs555414240 0.3428 0.088 1.0 N 0.698 0.358 None gnomAD-3.1.2 2.63E-05 None None None None I None 2.41E-05 0 0 0 1.93424E-04 None 0 0 2.94E-05 0 0
R/Q 27341 Ig-140 64 rs555414240 0.3428 0.088 1.0 N 0.698 0.358 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
R/Q 27341 Ig-140 64 rs555414240 0.3428 0.088 1.0 N 0.698 0.358 None gnomAD-4.0.0 2.41684E-05 None None None None I None 1.33312E-05 0 None 0 8.91782E-05 None 0 1.65017E-04 2.3735E-05 3.29402E-05 3.20154E-05
R/W 27341 Ig-140 64 rs746488250 0.5621 -0.499 1.0 N 0.748 0.38 0.326616659874 gnomAD-2.1.1 1.79E-05 None None None None I None 4.13E-05 2.83E-05 None 0 0 None 0 None 0 2.35E-05 0
R/W 27341 Ig-140 64 rs746488250 0.5621 -0.499 1.0 N 0.748 0.38 0.326616659874 gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
R/W 27341 Ig-140 64 rs746488250 0.5621 -0.499 1.0 N 0.748 0.38 0.326616659874 gnomAD-4.0.0 2.04521E-05 None None None None I None 2.6713E-05 1.66728E-05 None 0 4.45712E-05 None 0 0 1.94965E-05 3.29402E-05 3.20277E-05
R/G 27738 Ig-141 63 None 0.981 None 1.0 N 0.593 0.413 0.340753184043 gnomAD-4.0.0 6.84305E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99518E-07 0 0
R/K 27738 Ig-141 63 None 0.6745 None 0.997 N 0.546 0.362 0.298745278005 gnomAD-4.0.0 1.59179E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
K/E 28027 Ig-142 65 rs1647599149 0.1679 None 0.027 N 0.278 0.087 0.220303561663 gnomAD-4.0.0 3.60101E-06 None None None None N None 0 0 None 0 0 None 0 0 3.93756E-06 0 0
K/N 28027 Ig-142 65 None 0.5013 None None N 0.247 0.212 0.136095386433 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
R/K 28817 Ig-144 63 rs770715791 0.4038 0.013 0.997 N 0.569 0.29 0.317958651998 gnomAD-2.1.1 8.16E-06 None None None None N None 0 0 None 0 0 None 6.73E-05 None 0 0 0
R/K 28817 Ig-144 63 rs770715791 0.4038 0.013 0.997 N 0.569 0.29 0.317958651998 gnomAD-4.0.0 4.79886E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.33877E-05 0
T/I 29109 Ig-145 65 rs753496654 0.1092 0.008 None N 0.197 0.165 0.159798565429 gnomAD-2.1.1 8.05E-06 None None None None N None 0 5.79E-05 None 0 0 None 0 None 0 0 0
T/I 29109 Ig-145 65 rs753496654 0.1092 0.008 None N 0.197 0.165 0.159798565429 gnomAD-4.0.0 3.18221E-06 None None None None N None 0 4.57247E-05 None 0 0 None 0 0 0 0 0
R/C 29505 Ig-146 62 rs372360369 0.6776 0.005 1.0 N 0.749 0.367 None gnomAD-2.1.1 2.5E-05 None None None None N None 2.06594E-04 0 None 0 5.15E-05 None 0 None 0 7.82E-06 0
R/C 29505 Ig-146 62 rs372360369 0.6776 0.005 1.0 N 0.749 0.367 None gnomAD-3.1.2 4.6E-05 None None None None N None 1.44767E-04 6.55E-05 0 0 0 None 0 0 0 0 0
R/C 29505 Ig-146 62 rs372360369 0.6776 0.005 1.0 N 0.749 0.367 None gnomAD-4.0.0 2.10706E-05 None None None None N None 2.93631E-04 5.00133E-05 None 0 0 None 0 0 7.62833E-06 0 0
R/G 29505 Ig-146 62 None 0.9323 None 1.0 N 0.58 0.341 0.436239592564 gnomAD-4.0.0 6.84236E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99449E-07 0 0
R/H 29505 Ig-146 62 rs143193258 0.5178 -0.631 1.0 N 0.75 0.368 None gnomAD-2.1.1 8.93E-05 None None None None N None 0 6.22912E-04 None 0 0 None 0 None 0 2.35E-05 0
R/H 29505 Ig-146 62 rs143193258 0.5178 -0.631 1.0 N 0.75 0.368 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 1.96464E-04 0 0 0 None 0 0 0 2.07211E-04 0
R/H 29505 Ig-146 62 rs143193258 0.5178 -0.631 1.0 N 0.75 0.368 None 1000 genomes 3.99361E-04 None None None None N None 0 2.9E-03 None None 0 0 None None None 0 None
R/H 29505 Ig-146 62 rs143193258 0.5178 -0.631 1.0 N 0.75 0.368 None gnomAD-4.0.0 4.39959E-05 None None None None N None 2.66475E-05 4.16597E-04 None 0 0 None 0 0 3.39036E-05 4.39194E-05 0
R/S 29505 Ig-146 62 None 0.9724 None 1.0 N 0.631 0.343 0.275641507738 gnomAD-4.0.0 6.84236E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65678E-05
R/C 29904 Ig-147 63 rs1222259013 0.7661 None 1.0 D 0.751 0.426 0.581344535356 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 29904 Ig-147 63 rs1222259013 0.7661 None 1.0 D 0.751 0.426 0.581344535356 gnomAD-4.0.0 3.71825E-06 None None None None N None 0 0 None 0 0 None 0 0 4.23809E-06 1.09791E-05 0
R/H 29904 Ig-147 63 None 0.6352 -0.66 1.0 N 0.759 0.486 None gnomAD-2.1.1 6.78E-05 None None None None N None 3.30688E-04 2.26257E-04 None 0 0 None 0 None 0 2.34E-05 0
R/H 29904 Ig-147 63 None 0.6352 -0.66 1.0 N 0.759 0.486 None gnomAD-3.1.2 3.94E-05 None None None None N None 1.20656E-04 6.55E-05 0 0 0 None 0 0 0 0 0
R/H 29904 Ig-147 63 None 0.6352 -0.66 1.0 N 0.759 0.486 None gnomAD-4.0.0 2.10697E-05 None None None None N None 1.60179E-04 2.33341E-04 None 0 0 None 0 0 5.93317E-06 1.09794E-05 0
R/L 29904 Ig-147 63 rs397517744 0.8954 0.572 1.0 N 0.577 0.445 0.435699915968 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
R/L 29904 Ig-147 63 rs397517744 0.8954 0.572 1.0 N 0.577 0.445 0.435699915968 gnomAD-4.0.0 1.36843E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79892E-06 0 0
K/T 30196 Ig-148 65 None 0.4985 None 1.0 N 0.667 0.454 0.302793454619 gnomAD-4.0.0 1.59921E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.03472E-05
R/Q 30591 Ig-149 60 rs752576185 0.3127 0.429 1.0 N 0.683 0.369 0.16115917748 gnomAD-2.1.1 3.22E-05 None None None None I None 0 0 None 0 0 None 9.81E-05 None 4.65E-05 2.66E-05 1.65563E-04
R/Q 30591 Ig-149 60 rs752576185 0.3127 0.429 1.0 N 0.683 0.369 0.16115917748 gnomAD-3.1.2 3.94E-05 None None None None I None 4.83E-05 6.55E-05 0 0 0 None 0 0 4.41E-05 0 0
R/Q 30591 Ig-149 60 rs752576185 0.3127 0.429 1.0 N 0.683 0.369 0.16115917748 gnomAD-4.0.0 3.78027E-05 None None None None I None 5.34231E-05 1.667E-05 None 3.37906E-05 0 None 3.12471E-05 1.64474E-04 3.39047E-05 1.09791E-04 3.20236E-05
R/W 30591 Ig-149 60 rs760668673 0.538 -0.309 1.0 N 0.77 0.421 0.345859378078 gnomAD-2.1.1 3.62E-05 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 7.1E-05 0
R/W 30591 Ig-149 60 rs760668673 0.538 -0.309 1.0 N 0.77 0.421 0.345859378078 gnomAD-4.0.0 1.2316E-05 None None None None I None 0 0 None 0 0 None 3.74546E-05 0 1.16934E-05 3.47842E-05 0
R/K 30988 Ig-150 62 None 0.332 None 0.997 N 0.595 0.293 0.185906805712 gnomAD-4.0.0 1.59116E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02444E-05
R/G 31680 Ig-152 60 rs760992930 0.9445 -0.377 1.0 N 0.586 0.426 0.424194796918 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
R/G 31680 Ig-152 60 rs760992930 0.9445 -0.377 1.0 N 0.586 0.426 0.424194796918 gnomAD-4.0.0 1.59126E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85838E-06 0 0
R/Q 32077 Ig-153 61 rs369835255 0.6653 0.207 1.0 N 0.707 0.37 None gnomAD-2.1.1 3.21E-05 None None None None I None 8.27E-05 0 None 0 0 None 0 None 0 5.46E-05 0
R/Q 32077 Ig-153 61 rs369835255 0.6653 0.207 1.0 N 0.707 0.37 None gnomAD-3.1.2 5.26E-05 None None None None I None 9.67E-05 0 0 0 0 None 0 0 2.94E-05 4.16146E-04 0
R/Q 32077 Ig-153 61 rs369835255 0.6653 0.207 1.0 N 0.707 0.37 None gnomAD-4.0.0 2.479E-05 None None None None I None 5.33589E-05 0 None 0 0 None 0 1.65125E-04 2.62784E-05 4.39309E-05 0
R/W 32077 Ig-153 61 rs751316145 0.8997 -0.36 1.0 N 0.769 0.5 None gnomAD-2.1.1 1.07E-05 None None None None I None 0 0 None 0 5.13E-05 None 3.27E-05 None 0 7.81E-06 0
R/W 32077 Ig-153 61 rs751316145 0.8997 -0.36 1.0 N 0.769 0.5 None gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/W 32077 Ig-153 61 rs751316145 0.8997 -0.36 1.0 N 0.769 0.5 None gnomAD-4.0.0 5.5781E-06 None None None None I None 0 0 None 0 2.22866E-05 None 0 0 3.39073E-06 3.29446E-05 1.60143E-05
I/S 32371 Ig-154 65 rs748682168 0.3594 -0.099 1.0 N 0.589 0.451 0.574808824563 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
I/S 32371 Ig-154 65 rs748682168 0.3594 -0.099 1.0 N 0.589 0.451 0.574808824563 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/S 32371 Ig-154 65 rs748682168 0.3594 -0.099 1.0 N 0.589 0.451 0.574808824563 gnomAD-4.0.0 3.22242E-05 None None None None I None 0 0 None 0 0 None 0 0 4.40757E-05 0 0
I/V 32371 Ig-154 65 rs397517766 0.0893 0.028 0.993 N 0.268 0.214 None gnomAD-2.1.1 1.07E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.34E-05 0
I/V 32371 Ig-154 65 rs397517766 0.0893 0.028 0.993 N 0.268 0.214 None gnomAD-3.1.2 3.94E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 7.35E-05 0 0
I/V 32371 Ig-154 65 rs397517766 0.0893 0.028 0.993 N 0.268 0.214 None gnomAD-4.0.0 6.63056E-05 None None None None I None 4.00363E-05 0 None 0 0 None 0 0 8.56098E-05 0 4.80354E-05
R/S 32767 Ig-155 60 rs995110630 0.8281 -0.142 0.98 N 0.466 0.285 0.252681307341 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 1.11433E-04 None 0 None 0 0 0
R/S 32767 Ig-155 60 rs995110630 0.8281 -0.142 0.98 N 0.466 0.285 0.252681307341 gnomAD-4.0.0 1.3684E-06 None None None None N None 0 0 None 0 5.03931E-05 None 0 0 0 0 0
R/C 33261 Ig-157 59 rs1064797274 0.2899 -0.295 0.998 N 0.612 0.293 0.442054744378 gnomAD-2.1.1 1.62E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.59E-05 0
R/C 33261 Ig-157 59 rs1064797274 0.2899 -0.295 0.998 N 0.612 0.293 0.442054744378 gnomAD-3.1.2 1.32E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
R/C 33261 Ig-157 59 rs1064797274 0.2899 -0.295 0.998 N 0.612 0.293 0.442054744378 gnomAD-4.0.0 8.06246E-06 None None None None N None 0 1.6699E-05 None 0 2.23125E-05 None 0 0 5.93659E-06 0 6.40943E-05
R/H 33261 Ig-157 59 rs373473754 0.1367 -0.915 0.01 N 0.191 0.15 None gnomAD-2.1.1 1.08E-05 None None None None N None 8.33E-05 0 None 0 0 None 3.3E-05 None 0 0 0
R/H 33261 Ig-157 59 rs373473754 0.1367 -0.915 0.01 N 0.191 0.15 None gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
R/H 33261 Ig-157 59 rs373473754 0.1367 -0.915 0.01 N 0.191 0.15 None gnomAD-4.0.0 6.2022E-06 None None None None N None 4.00877E-05 0 None 0 0 None 0 0 5.08858E-06 1.10042E-05 0
R/G 33661 Ig-159 66 rs998389353 0.7598 -0.544 1.0 N 0.567 0.356 0.385417323374 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
R/G 33661 Ig-159 66 rs998389353 0.7598 -0.544 1.0 N 0.567 0.356 0.385417323374 gnomAD-4.0.0 2.05263E-06 None None None None N None 0 4.47207E-05 None 0 0 None 0 0 8.99467E-07 0 0
R/K 33661 Ig-159 66 rs201857158 0.2129 0.101 0.972 N 0.505 0.223 0.136095386433 gnomAD-2.1.1 3.60869E-04 None None None None N None 0 0 None 0 0 None 3.17035E-03 None 0 0 5.61798E-04
R/K 33661 Ig-159 66 rs201857158 0.2129 0.101 0.972 N 0.505 0.223 0.136095386433 gnomAD-3.1.2 1.3143E-04 None None None None N None 0 0 0 0 0 None 0 0 0 4.13736E-03 0
R/K 33661 Ig-159 66 rs201857158 0.2129 0.101 0.972 N 0.505 0.223 0.136095386433 1000 genomes 7.98722E-04 None None None None N None 0 0 None None 0 0 None None None 4.1E-03 None
R/K 33661 Ig-159 66 rs201857158 0.2129 0.101 0.972 N 0.505 0.223 0.136095386433 gnomAD-4.0.0 2.05723E-04 None None None None N None 0 0 None 0 2.22846E-05 None 0 1.65017E-04 2.54281E-06 3.46933E-03 1.76056E-04
P/L 34428 Ig-162 66 None 0.2649 None 0.217 N 0.419 0.291 0.335414705075 gnomAD-4.0.0 1.5915E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85767E-06 0 0
A/D 35193 Ig-164 65 rs1380574216 0.1779 -0.311 0.884 N 0.387 0.123 0.270889551736 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 6.41849E-04 None 0 None 0 0 0
A/D 35193 Ig-164 65 rs1380574216 0.1779 -0.311 0.884 N 0.387 0.123 0.270889551736 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92456E-04 None 0 0 0 0 0
A/D 35193 Ig-164 65 rs1380574216 0.1779 -0.311 0.884 N 0.387 0.123 0.270889551736 gnomAD-4.0.0 6.57237E-06 None None None None N None 0 0 None 0 1.92456E-04 None 0 0 0 0 0
A/S 35193 Ig-164 65 rs763944153 0.0869 -0.25 0.012 N 0.113 0.131 None gnomAD-2.1.1 2.5E-05 None None None None N None 0 0 None 0 0 None 0 None 4E-05 4.68E-05 0
A/S 35193 Ig-164 65 rs763944153 0.0869 -0.25 0.012 N 0.113 0.131 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/S 35193 Ig-164 65 rs763944153 0.0869 -0.25 0.012 N 0.113 0.131 None gnomAD-4.0.0 1.40908E-05 None None None None N None 0 0 None 0 0 None 1.56922E-05 0 2.15329E-05 0 2.84398E-05
A/V 35193 Ig-164 65 rs1380574216 0.1142 -0.042 0.309 N 0.295 0.048 0.136095386433 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 5.56E-05 None 0 None 0 0 0
A/V 35193 Ig-164 65 rs1380574216 0.1142 -0.042 0.309 N 0.295 0.048 0.136095386433 gnomAD-4.0.0 1.5909E-06 None None None None N None 0 0 None 0 2.77239E-05 None 0 0 0 0 0
E/K 35351 Ig-165 66 rs1688663690 0.116 None 0.811 N 0.383 0.174 0.163833314356 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06868E-04 0
E/K 35351 Ig-165 66 rs1688663690 0.116 None 0.811 N 0.383 0.174 0.163833314356 gnomAD-4.0.0 6.57047E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.06868E-04 0
E/Q 35351 Ig-165 66 rs1688663690 0.1653 None 0.211 N 0.235 0.096 0.146414634003 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 3.16456E-03 0 0 0
E/Q 35351 Ig-165 66 rs1688663690 0.1653 None 0.211 N 0.235 0.096 0.146414634003 gnomAD-4.0.0 2.56117E-06 None None None None N None 0 0 None 0 0 None 0 4.50248E-04 0 0 0
T/I 35484 Ig-166 65 rs754163825 0.1086 None None N 0.126 0.073 0.110078149338 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 35484 Ig-166 65 rs754163825 0.1086 None None N 0.126 0.073 0.110078149338 gnomAD-4.0.0 6.57134E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46998E-05 0 0
T/N 35484 Ig-166 65 None 0.1055 None 0.022 N 0.205 0.061 0.12205267543 gnomAD-4.0.0 5.4854E-06 None None None None N None 0 0 None 0 0 None 0 0 6.30035E-06 0 1.65937E-05
T/P 35484 Ig-166 65 None 0.1262 None 0.044 N 0.293 0.104 0.0401082797425 gnomAD-4.0.0 1.59899E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86366E-06 0 0
T/S 35484 Ig-166 65 rs754163825 0.1049 0.213 0.005 N 0.178 0.037 0.0401082797425 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
T/S 35484 Ig-166 65 rs754163825 0.1049 0.213 0.005 N 0.178 0.037 0.0401082797425 gnomAD-4.0.0 3.42838E-06 None None None None N None 0 0 None 0 0 None 0 0 4.50025E-06 0 0
K/Q 35963 Ig-169 67 rs1558953226 0.1677 None 0.92 N 0.38 0.158 0.132336055621 gnomAD-4.0.0 1.59094E-06 None None None 0.298(OBSL1) -0.354(OBSCN) N None 0 0 None 0 2.77285E-05 None 0 0 0 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.