Structural position:

  • Domain Type: Ig
  • Aligned Position: 151
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
E/G 1359 Ig-5 69 rs370978752 0.6526 -1.327 1.0 N 0.776 0.687 None gnomAD-2.1.1 5.32E-05 None None None None N None 0 2.82E-05 None 0 0 None 0 None 0 1.08939E-04 0
E/G 1359 Ig-5 69 rs370978752 0.6526 -1.327 1.0 N 0.776 0.687 None gnomAD-3.1.2 6.6E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 1359 Ig-5 69 rs370978752 0.6526 -1.327 1.0 N 0.776 0.687 None gnomAD-4.0.0 4.21509E-05 None None None None N None 0 5.00584E-05 None 0 0 None 0 4.93259E-04 4.83156E-05 2.19693E-05 4.80261E-05
S/C 1625 Ig-7 70 rs185789611 0.2242 -0.466 0.998 D 0.696 0.562 None gnomAD-2.1.1 3.91E-05 None None None None N None 0 0 None 0 5.53153E-04 None 0 None 0 0 0
S/C 1625 Ig-7 70 rs185789611 0.2242 -0.466 0.998 D 0.696 0.562 None gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 9.62279E-04 None 0 0 0 0 0
S/C 1625 Ig-7 70 rs185789611 0.2242 -0.466 0.998 D 0.696 0.562 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
S/C 1625 Ig-7 70 rs185789611 0.2242 -0.466 0.998 D 0.696 0.562 None gnomAD-4.0.0 1.79674E-05 None None None None N None 0 0 None 0 6.24331E-04 None 0 0 0 0 1.59995E-05
S/G 1772 Ig-8 70 rs150725992 0.3263 -0.999 0.999 D 0.54 0.462 None gnomAD-2.1.1 1.03114E-04 None None None None I None 4.01E-05 0 None 0 0 None 0 None 0 2.17466E-04 0
S/G 1772 Ig-8 70 rs150725992 0.3263 -0.999 0.999 D 0.54 0.462 None gnomAD-3.1.2 8.54E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 1.76398E-04 0 0
S/G 1772 Ig-8 70 rs150725992 0.3263 -0.999 0.999 D 0.54 0.462 None gnomAD-4.0.0 1.6252E-04 None None None None I None 1.33451E-05 0 None 0 0 None 0 0 2.17797E-04 0 6.40266E-05
T/I 1907 Ig-9 67 None 0.5084 None 0.984 N 0.623 0.425 0.463672176093 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/F 2146 Ig-10 69 None 0.9541 None 1.0 D 0.897 0.639 0.781250577677 gnomAD-4.0.0 1.59071E-06 None None None None N None 0 2.28718E-05 None 0 0 None 0 0 0 0 0
A/D 2241 Ig-11 68 None 0.2946 None 0.005 N 0.284 0.292 0.492749560936 gnomAD-4.0.0 1.59088E-06 None None None None N None 0 2.28697E-05 None 0 0 None 0 0 0 0 0
Q/E 2333 Ig-12 67 rs778177301 0.0835 -0.844 0.992 N 0.33 0.404 0.259272394797 gnomAD-2.1.1 7.97E-06 None None None None N None 0 5.79E-05 None 0 0 None 0 None 0 0 0
Q/E 2333 Ig-12 67 rs778177301 0.0835 -0.844 0.992 N 0.33 0.404 0.259272394797 gnomAD-4.0.0 2.73632E-06 None None None None N None 0 4.47247E-05 None 0 0 None 0 0 1.79862E-06 0 0
Q/R 2333 Ig-12 67 None 0.1751 None 0.997 N 0.45 0.481 0.303123707472 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
A/V 2422 Ig-13 67 rs1365893831 0.1912 None 0.811 D 0.453 0.255 0.563581552253 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/V 2422 Ig-13 67 rs1365893831 0.1912 None 0.811 D 0.453 0.255 0.563581552253 gnomAD-4.0.0 6.57376E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47042E-05 0 0
E/K 2512 Ig-14 68 rs116049561 0.1613 0.225 0.96 D 0.596 0.422 None gnomAD-2.1.1 2.12E-05 None None None None N None 4.01E-05 0 None 0 0 None 0 None 0 3.88E-05 0
E/K 2512 Ig-14 68 rs116049561 0.1613 0.225 0.96 D 0.596 0.422 None gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
E/K 2512 Ig-14 68 rs116049561 0.1613 0.225 0.96 D 0.596 0.422 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
E/K 2512 Ig-14 68 rs116049561 0.1613 0.225 0.96 D 0.596 0.422 None gnomAD-4.0.0 4.39899E-05 None None None None N None 2.66638E-05 0 None 0 0 None 0 0 5.59333E-05 0 4.8E-05
E/G 2599 Ig-15 67 rs2091784595 0.3914 None 1.0 N 0.775 0.618 0.594197360623 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 2599 Ig-15 67 rs2091784595 0.3914 None 1.0 N 0.775 0.618 0.594197360623 gnomAD-4.0.0 3.04488E-06 None None None None N None 0 0 None 0 0 None 0 0 3.61491E-06 0 0
E/V 2599 Ig-15 67 rs2091784595 0.636 None 1.0 D 0.826 0.597 0.673503988595 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/V 2599 Ig-15 67 rs2091784595 0.636 None 1.0 D 0.826 0.597 0.673503988595 gnomAD-4.0.0 6.56996E-06 None None None None N None 0 6.54707E-05 None 0 0 None 0 0 0 0 0
I/T 2686 Ig-16 66 None 0.073 None 0.029 N 0.542 0.312 0.606340826685 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 2686 Ig-16 66 rs756935554 0.0745 -1.585 None N 0.163 0.064 None gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
I/V 2686 Ig-16 66 rs756935554 0.0745 -1.585 None N 0.163 0.064 None gnomAD-4.0.0 9.57725E-06 None None None None N None 0 4.47307E-05 None 0 0 None 0 0 1.07916E-05 0 0
E/D 2774 Ig-17 68 None 0.7353 None 0.999 D 0.457 0.469 0.297375071883 gnomAD-4.0.0 1.59052E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85647E-06 0 0
E/K 2774 Ig-17 68 None 0.7559 0.574 0.999 D 0.587 0.495 0.501559347837 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 5.45E-05 None 0 None 0 0 0
E/K 2774 Ig-17 68 None 0.7559 0.574 0.999 D 0.587 0.495 0.501559347837 gnomAD-3.1.2 1.31E-05 None None None None I None 0 1.30907E-04 0 0 0 None 0 0 0 0 0
E/K 2774 Ig-17 68 None 0.7559 0.574 0.999 D 0.587 0.495 0.501559347837 gnomAD-4.0.0 1.15249E-05 None None None None I None 0 3.38926E-05 None 0 1.21224E-04 None 0 0 2.39169E-06 1.33994E-05 0
E/Q 2774 Ig-17 68 rs763666119 0.5528 0.19 1.0 N 0.599 0.438 0.385578977469 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.83E-06 0
E/Q 2774 Ig-17 68 rs763666119 0.5528 0.19 1.0 N 0.599 0.438 0.385578977469 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/Q 2774 Ig-17 68 rs763666119 0.5528 0.19 1.0 N 0.599 0.438 0.385578977469 gnomAD-4.0.0 6.57065E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
A/S 2861 Ig-18 67 rs1383547916 0.0999 None 0.689 N 0.32 0.224 0.242244723065 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
A/S 2861 Ig-18 67 rs1383547916 0.0999 None 0.689 N 0.32 0.224 0.242244723065 gnomAD-4.0.0 4.05965E-06 None None None None N None 1.74697E-05 0 None 0 0 None 0 0 3.61472E-06 0 0
S/L 2948 Ig-19 67 rs397517763 0.1686 -0.312 0.586 D 0.574 0.497 0.754234975006 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.85E-06 0
S/L 2948 Ig-19 67 rs397517763 0.1686 -0.312 0.586 D 0.574 0.497 0.754234975006 gnomAD-4.0.0 7.52511E-06 None None None None N None 0 0 None 0 0 None 0 0 9.89257E-06 0 0
A/G 3035 Ig-20 67 None 0.4463 None 0.031 N 0.197 0.253 0.267755039894 gnomAD-4.0.0 6.84092E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99295E-07 0 0
A/T 3035 Ig-20 67 rs745745046 0.4484 -0.94 0.961 N 0.512 0.309 0.398872588132 gnomAD-2.1.1 7.96E-06 None None None None N None 0 5.79E-05 None 0 0 None 0 None 0 0 0
A/T 3035 Ig-20 67 rs745745046 0.4484 -0.94 0.961 N 0.512 0.309 0.398872588132 gnomAD-4.0.0 1.59061E-06 None None None None N None 0 2.28676E-05 None 0 0 None 0 0 0 0 0
A/V 3035 Ig-20 67 None 0.5968 None 0.248 N 0.359 0.288 0.415055319159 gnomAD-4.0.0 2.05228E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69789E-06 0 0
A/P 3215 Ig-22 69 None 0.972 None 0.999 D 0.861 0.659 0.516326692288 gnomAD-4.0.0 1.59051E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.0217E-05
A/P 3306 Ig-23 68 None 0.962 None 0.991 D 0.696 0.462 0.659281739986 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/V 3306 Ig-23 68 rs879006488 0.3271 -0.296 0.989 D 0.471 0.27 0.575180444326 gnomAD-2.1.1 1.06E-05 None None None None N None 4.01E-05 0 None 0 0 None 6.53E-05 None 0 0 0
A/V 3306 Ig-23 68 rs879006488 0.3271 -0.296 0.989 D 0.471 0.27 0.575180444326 gnomAD-3.1.2 4.6E-05 None None None None N None 1.20755E-04 6.54E-05 0 0 0 None 0 0 0 2.07297E-04 0
A/V 3306 Ig-23 68 rs879006488 0.3271 -0.296 0.989 D 0.471 0.27 0.575180444326 gnomAD-4.0.0 9.9136E-06 None None None None N None 9.34779E-05 1.66678E-05 None 0 0 None 0 0 5.08472E-06 2.19587E-05 0
E/K 3411 Ig-24 67 rs2088211648 0.1674 None 0.999 D 0.591 0.409 0.579595062312 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/K 3411 Ig-24 67 rs2088211648 0.1674 None 0.999 D 0.591 0.409 0.579595062312 gnomAD-4.0.0 6.57186E-06 None None None None N None 2.41301E-05 0 None 0 0 None 0 0 0 0 0
E/V 3411 Ig-24 67 rs2088210968 0.3594 None 1.0 N 0.822 0.585 0.698178878506 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/V 3411 Ig-24 67 rs2088210968 0.3594 None 1.0 N 0.822 0.585 0.698178878506 gnomAD-4.0.0 6.57117E-06 None None None None N None 0 6.54879E-05 None 0 0 None 0 0 0 0 0
A/S 3534 Ig-25 70 rs1205126810 0.1129 None None None None 0.201 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/S 3534 Ig-25 70 rs1205126810 0.1129 None None None None 0.201 None gnomAD-4.0.0 6.56978E-06 None None None None N None 2.41173E-05 0 None 0 0 None 0 0 0 0 0
Q/E 3727 Ig-26 68 rs1561082102 0.0821 None None None None 0.092 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
Q/E 3727 Ig-26 68 rs1561082102 0.0821 None None None None 0.092 None gnomAD-4.0.0 1.59122E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
S/G 4006 Ig-28 69 rs1391193598 0.1035 None None N 0.11 0.099 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 9.41E-05 0 1.47E-05 0 0
S/G 4006 Ig-28 69 rs1391193598 0.1035 None None N 0.11 0.099 None gnomAD-4.0.0 3.04478E-06 None None None None N None 0 0 None 0 0 None 9.17431E-05 0 2.40982E-06 0 0
S/N 4006 Ig-28 69 rs1366799021 0.1912 -1.096 0.117 D 0.502 0.239 None gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.11669E-04 None 0 None 0 8.9E-06 0
S/N 4006 Ig-28 69 rs1366799021 0.1912 -1.096 0.117 D 0.502 0.239 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/N 4006 Ig-28 69 rs1366799021 0.1912 -1.096 0.117 D 0.502 0.239 None gnomAD-4.0.0 5.1269E-06 None None None None N None 0 0 None 0 4.85013E-05 None 0 0 2.39279E-06 1.33994E-05 0
S/R 4006 Ig-28 69 rs780375598 0.4889 -0.637 0.317 D 0.563 0.142 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 9.96E-05 0 None 0 None 0 0 0
S/R 4006 Ig-28 69 rs780375598 0.4889 -0.637 0.317 D 0.563 0.142 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/K 4672 Ig-29 67 rs1553935908 0.1202 None 0.09 N 0.495 0.059 None gnomAD-4.0.0 5.10927E-06 None None None None N None 0 0 None 0 0 None 0 0 9.18943E-06 0 0
Q/R 4672 Ig-29 67 rs762907912 0.1249 -0.193 0.193 D 0.5 0.184 None gnomAD-2.1.1 4.51E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.83E-06 0
Q/R 4672 Ig-29 67 rs762907912 0.1249 -0.193 0.193 D 0.5 0.184 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/R 4672 Ig-29 67 rs762907912 0.1249 -0.193 0.193 D 0.5 0.184 None gnomAD-4.0.0 4.05914E-06 None None None None N None 0 0 None 0 0 None 0 0 7.60699E-06 0 0
C/Y 4767 Ig-30 68 rs1175326019 0.6104 None 0.996 N 0.591 0.348 0.775817181622 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
R/G 4862 Ig-31 68 rs952359009 0.1551 -1.246 None N 0.272 0.227 0.46123363591 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
R/G 4862 Ig-31 68 rs952359009 0.1551 -1.246 None N 0.272 0.227 0.46123363591 gnomAD-3.1.2 1.97E-05 None None None None N None 7.23E-05 0 0 0 0 None 0 0 0 0 0
R/G 4862 Ig-31 68 rs952359009 0.1551 -1.246 None N 0.272 0.227 0.46123363591 gnomAD-4.0.0 1.97075E-05 None None None None N None 7.23484E-05 0 None 0 0 None 0 0 0 0 0
R/S 4862 Ig-31 68 rs1260217446 0.3603 None 0.012 N 0.551 0.15 0.255777322467 gnomAD-4.0.0 1.59123E-06 None None None None N None 0 0 None 0 2.77531E-05 None 0 0 0 0 0
R/T 4862 Ig-31 68 None 0.1792 None 0.055 N 0.587 0.122 0.45783149361 gnomAD-4.0.0 1.59123E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85799E-06 0 0
S/L 4955 Ig-32 68 None 0.1037 None 0.565 D 0.605 0.459 0.579204274476 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
S/G 5049 Ig-33 69 None 0.1432 None 0.939 N 0.437 0.346 0.454518106513 gnomAD-4.0.0 1.5913E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85838E-06 0 0
S/N 5049 Ig-33 69 rs1314741857 0.4175 -0.438 0.939 D 0.491 0.26 0.429320821379 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/N 5049 Ig-33 69 rs1314741857 0.4175 -0.438 0.939 D 0.491 0.26 0.429320821379 gnomAD-4.0.0 4.77432E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.30046E-05 0
V/A 5142 Ig-34 68 rs1400360100 0.1094 -0.618 0.025 N 0.303 0.168 0.420080204436 gnomAD-2.1.1 3.19E-05 None None None None N None 1.1489E-04 0 None 0 0 None 0 None 0 0 0
V/A 5142 Ig-34 68 rs1400360100 0.1094 -0.618 0.025 N 0.303 0.168 0.420080204436 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
V/A 5142 Ig-34 68 rs1400360100 0.1094 -0.618 0.025 N 0.303 0.168 0.420080204436 gnomAD-4.0.0 3.84689E-06 None None None None N None 3.38364E-05 0 None 0 0 None 0 0 2.3954E-06 0 0
V/F 5142 Ig-34 68 rs1417902280 0.251 -0.75 0.967 N 0.683 0.294 0.781774819458 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
V/F 5142 Ig-34 68 rs1417902280 0.251 -0.75 0.967 N 0.683 0.294 0.781774819458 gnomAD-4.0.0 6.84316E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99556E-07 0 0
V/I 5142 Ig-34 68 None 0.0723 None 0.025 N 0.267 0.08 0.344483371355 gnomAD-4.0.0 1.36863E-06 None None None None N None 2.98882E-05 0 None 0 0 None 0 0 8.99556E-07 0 0
G/R 5235 Ig-35 68 None 0.1818 None 0.638 N 0.757 0.286 0.558422169324 gnomAD-4.0.0 1.59126E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43303E-05 0
A/S 5424 Ig-37 68 None 0.0938 None 0.014 N 0.148 0.114 0.16115917748 gnomAD-4.0.0 3.18415E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86599E-05 0
A/V 5424 Ig-37 68 rs1466084495 0.1354 -0.412 0.565 D 0.452 0.318 None gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
A/V 5424 Ig-37 68 rs1466084495 0.1354 -0.412 0.565 D 0.452 0.318 None gnomAD-4.0.0 1.59207E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85894E-06 0 0
S/A 5517 Ig-38 68 rs200520316 0.0802 -0.951 0.987 N 0.45 0.247 None gnomAD-2.1.1 8.86E-05 None None None None N None 0 0 None 0 0 None 7.19142E-04 None 0 0 0
S/A 5517 Ig-38 68 rs200520316 0.0802 -0.951 0.987 N 0.45 0.247 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 0 4.14422E-04 0
S/A 5517 Ig-38 68 rs200520316 0.0802 -0.951 0.987 N 0.45 0.247 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
S/A 5517 Ig-38 68 rs200520316 0.0802 -0.951 0.987 N 0.45 0.247 None gnomAD-4.0.0 4.70959E-05 None None None None N None 0 0 None 0 0 None 0 1.65125E-04 8.47642E-07 7.79586E-04 4.80215E-05
S/L 5517 Ig-38 68 rs769165258 0.1477 -0.241 0.998 N 0.592 0.43 0.776151870229 gnomAD-2.1.1 5.36E-05 None None None None N None 8.27E-05 2.26629E-04 None 0 2.05592E-04 None 3.27E-05 None 0 0 0
S/L 5517 Ig-38 68 rs769165258 0.1477 -0.241 0.998 N 0.592 0.43 0.776151870229 gnomAD-3.1.2 4.6E-05 None None None None N None 1.20662E-04 6.55E-05 0 0 1.92827E-04 None 0 0 0 0 0
S/L 5517 Ig-38 68 rs769165258 0.1477 -0.241 0.998 N 0.592 0.43 0.776151870229 gnomAD-4.0.0 1.92126E-05 None None None None N None 8.01025E-05 1.66756E-04 None 0 1.78396E-04 None 0 0 3.39064E-06 3.29439E-05 0
S/R 5611 Ig-39 69 rs775946529 0.6755 -0.264 1.0 N 0.871 0.438 0.644143578622 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
S/R 5611 Ig-39 69 rs775946529 0.6755 -0.264 1.0 N 0.871 0.438 0.644143578622 gnomAD-4.0.0 1.59133E-06 None None None None N None 0 0 None 0 2.77285E-05 None 0 0 0 0 0
D/N 5797 Ig-41 68 rs752644615 0.1123 -0.601 0.801 N 0.439 0.154 None gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
D/N 5797 Ig-41 68 rs752644615 0.1123 -0.601 0.801 N 0.439 0.154 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/N 5797 Ig-41 68 rs752644615 0.1123 -0.601 0.801 N 0.439 0.154 None gnomAD-4.0.0 6.57263E-06 None None None None N None 2.41266E-05 0 None 0 0 None 0 0 0 0 0
S/T 5890 Ig-42 68 rs775293848 0.0926 -0.426 0.961 N 0.473 0.235 0.262662153117 gnomAD-2.1.1 3.62E-05 None None None None N None 0 2.61081E-04 None 0 0 None 0 None 0 0 0
S/T 5890 Ig-42 68 rs775293848 0.0926 -0.426 0.961 N 0.473 0.235 0.262662153117 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
S/T 5890 Ig-42 68 rs775293848 0.0926 -0.426 0.961 N 0.473 0.235 0.262662153117 gnomAD-4.0.0 1.28158E-05 None None None None N None 0 1.69509E-04 None 0 0 None 0 0 0 0 0
S/G 5986 Ig-43 68 rs779199136 0.0892 -0.98 0.026 N 0.158 0.127 0.168933306366 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/G 5986 Ig-43 68 rs779199136 0.0892 -0.98 0.026 N 0.158 0.127 0.168933306366 gnomAD-4.0.0 4.1057E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.7971E-05 1.65706E-05
S/R 5986 Ig-43 68 None 0.6018 None 0.968 N 0.567 0.317 0.221019684889 gnomAD-4.0.0 1.36857E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79913E-06 0 0
S/T 5986 Ig-43 68 None 0.0943 None 0.026 N 0.298 0.139 0.159798565429 gnomAD-4.0.0 1.59167E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
S/G 6173 Ig-45 69 None 0.1196 None 0.999 N 0.521 0.363 0.425615883737 gnomAD-4.0.0 1.36846E-06 None None None None N None 2.98864E-05 0 None 0 0 None 0 0 0 1.15939E-05 0
S/N 6173 Ig-45 69 rs1243375835 0.3249 -0.225 0.999 N 0.562 0.361 0.44551302605 gnomAD-2.1.1 3.18E-05 None None None None N None 1.14705E-04 0 None 0 0 None 0 None 0 0 0
S/R 6173 Ig-45 69 rs1452419316 0.6997 -0.267 1.0 N 0.86 0.481 0.438913950225 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
S/R 6173 Ig-45 69 rs1452419316 0.6997 -0.267 1.0 N 0.86 0.481 0.438913950225 gnomAD-4.0.0 3.18277E-06 None None None None N None 0 0 None 0 0 None 0 0 5.7171E-06 0 0
T/A 6266 Ig-46 68 rs761009610 0.0637 -0.714 None N 0.105 0.057 0.0716867268079 gnomAD-2.1.1 8.07E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.93E-06 0
T/A 6266 Ig-46 68 rs761009610 0.0637 -0.714 None N 0.105 0.057 0.0716867268079 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.30976E-04 0 0 0 None 0 0 0 0 0
T/A 6266 Ig-46 68 rs761009610 0.0637 -0.714 None N 0.105 0.057 0.0716867268079 gnomAD-4.0.0 7.68805E-06 None None None None N None 0 5.08595E-05 None 0 0 None 0 0 7.18085E-06 0 0
T/I 6266 Ig-46 68 None 0.1029 None 0.004 N 0.428 0.067 0.290590437066 gnomAD-4.0.0 1.59174E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85922E-06 0 0
S/G 6359 Ig-47 68 None 0.0724 None 0.946 N 0.527 0.175 0.321951552304 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/N 6359 Ig-47 68 rs2079878720 0.1411 None 0.896 N 0.5 0.28 0.359963025489 gnomAD-4.0.0 6.84571E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16055E-05 0
S/R 6359 Ig-47 68 None 0.3813 None 0.059 N 0.311 0.296 0.242244723065 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/T 6359 Ig-47 68 None 0.0929 None 0.946 N 0.528 0.176 0.333154297509 gnomAD-4.0.0 6.84571E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99667E-07 0 0
S/G 6452 Ig-48 68 rs1352966588 0.115 None 0.906 N 0.479 0.384 0.376745185316 gnomAD-4.0.0 1.36899E-05 None None None None N None 0 0 None 0 2.52564E-05 None 0 0 1.43949E-05 0 4.97331E-05
S/R 6452 Ig-48 68 rs369275615 0.6279 None 0.936 N 0.503 0.393 0.143124449307 gnomAD-4.0.0 6.84557E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16012E-05 0
T/I 6548 Ig-49 68 None 0.3386 None 0.007 N 0.267 0.198 0.453307948783 gnomAD-4.0.0 6.84919E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00114E-07 0 0
T/S 6548 Ig-49 68 rs369899924 0.1198 -0.895 0.028 N 0.14 0.078 0.173771789658 gnomAD-2.1.1 8.1E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
T/S 6548 Ig-49 68 rs369899924 0.1198 -0.895 0.028 N 0.14 0.078 0.173771789658 gnomAD-4.0.0 2.05476E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70034E-06 0 0
T/A 6641 Ig-50 68 None 0.0889 None 0.001 N 0.141 0.096 0.0884992946249 gnomAD-4.0.0 1.5932E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86202E-06 0 0
T/I 6641 Ig-50 68 rs747240394 0.3739 None 0.175 N 0.539 0.135 0.332133492242 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
T/I 6641 Ig-50 68 rs747240394 0.3739 None 0.175 N 0.539 0.135 0.332133492242 gnomAD-4.0.0 6.57601E-06 None None None None N None 0 6.55652E-05 None 0 0 None 0 0 0 0 0
T/N 6641 Ig-50 68 rs747240394 0.1523 -0.292 0.096 N 0.467 0.089 0.262662153117 gnomAD-2.1.1 2.93278E-04 None None None None N None 0 2.26667E-03 None 0 0 None 0 None 0 0 2.81849E-04
T/N 6641 Ig-50 68 rs747240394 0.1523 -0.292 0.096 N 0.467 0.089 0.262662153117 gnomAD-3.1.2 7.23E-05 None None None None N None 0 7.21217E-04 0 0 0 None 0 0 0 0 0
T/N 6641 Ig-50 68 rs747240394 0.1523 -0.292 0.096 N 0.467 0.089 0.262662153117 gnomAD-4.0.0 1.23129E-04 None None None None N None 0 1.61148E-03 None 0 0 None 0 0 0 0 2.84689E-05
T/P 6641 Ig-50 68 rs768808788 0.2515 -0.597 0.301 D 0.544 0.259 0.321108458156 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
T/P 6641 Ig-50 68 rs768808788 0.2515 -0.597 0.301 D 0.544 0.259 0.321108458156 gnomAD-4.0.0 1.5932E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43497E-05 0
S/G 6735 Ig-51 69 None 0.1097 None 0.002 N 0.159 0.159 0.146414634003 gnomAD-4.0.0 1.59942E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.03656E-05
I/T 6828 Ig-52 68 None 0.0687 None 0.127 N 0.539 0.211 0.604712644391 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62502E-06 0 0
I/V 6828 Ig-52 68 rs1432785096 0.0638 -0.688 None N 0.141 0.086 0.383760037723 gnomAD-2.1.1 6.37E-05 None None None None N None 1.14758E-04 0 None 0 0 None 0 None 0 6.48E-05 0
I/V 6828 Ig-52 68 rs1432785096 0.0638 -0.688 None N 0.141 0.086 0.383760037723 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/V 6828 Ig-52 68 rs1432785096 0.0638 -0.688 None N 0.141 0.086 0.383760037723 gnomAD-4.0.0 3.0995E-06 None None None None N None 2.67073E-05 0 None 0 0 None 0 0 2.54344E-06 0 0
A/T 7015 Ig-54 68 rs779515185 0.0772 -1.171 None N 0.145 0.122 0.252162846088 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
A/T 7015 Ig-54 68 rs779515185 0.0772 -1.171 None N 0.145 0.122 0.252162846088 gnomAD-4.0.0 1.59182E-06 None None None None N None 0 0 None 0 2.77393E-05 None 0 0 0 0 0
A/V 7015 Ig-54 68 rs72648960 0.125 -0.531 0.096 N 0.438 0.243 None gnomAD-2.1.1 1.59927E-02 None None None None N None 1.61224E-03 1.52983E-03 None 1.08275E-02 1.22511E-01 None 2.66754E-02 None 2.33925E-02 2.96801E-03 1.48876E-02
A/V 7015 Ig-54 68 rs72648960 0.125 -0.531 0.096 N 0.438 0.243 None gnomAD-3.1.2 8.9011E-03 None None None None N None 1.68895E-03 1.89989E-03 4.38597E-03 1.09447E-02 1.23357E-01 None 2.43121E-02 3.16456E-03 2.54389E-03 2.57155E-02 9.07354E-03
A/V 7015 Ig-54 68 rs72648960 0.125 -0.531 0.096 N 0.438 0.243 None 1000 genomes 3.57428E-02 None None None None N None 8E-04 5.8E-03 None None 1.379E-01 8E-03 None None None 2.76E-02 None
A/V 7015 Ig-54 68 rs72648960 0.125 -0.531 0.096 N 0.438 0.243 None gnomAD-4.0.0 8.21613E-03 None None None None N None 1.41311E-03 1.61747E-03 None 1.07131E-02 1.30621E-01 None 2.48266E-02 1.58573E-02 1.70053E-03 2.62349E-02 1.27598E-02
M/L 7111 Ig-55 68 rs1283834442 0.0986 -0.393 0.004 N 0.102 0.172 0.482500522706 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
M/L 7111 Ig-55 68 rs1283834442 0.0986 -0.393 0.004 N 0.102 0.172 0.482500522706 gnomAD-4.0.0 6.84334E-07 None None None None N None 0 2.23674E-05 None 0 0 None 0 0 0 0 0
M/T 7111 Ig-55 68 rs374408615 0.0577 -0.212 None N 0.104 0.09 None gnomAD-2.1.1 2.86E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.26E-05 0
M/T 7111 Ig-55 68 rs374408615 0.0577 -0.212 None N 0.104 0.09 None gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 7.35E-05 0 0
M/T 7111 Ig-55 68 rs374408615 0.0577 -0.212 None N 0.104 0.09 None gnomAD-4.0.0 3.40884E-05 None None None None N None 0 0 None 0 0 None 0 0 4.23874E-05 0 8.00769E-05
M/V 7111 Ig-55 68 None 0.0671 None 0.004 N 0.157 0.151 0.335414705075 gnomAD-4.0.0 6.84334E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99619E-07 0 0
S/R 7204 Ig-56 68 rs780624577 0.6952 -0.175 0.997 N 0.708 0.438 0.448891444097 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.45E-05 0
S/R 7204 Ig-56 68 rs780624577 0.6952 -0.175 0.997 N 0.708 0.438 0.448891444097 gnomAD-4.0.0 4.79094E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29729E-06 0 0
A/G 7297 Ig-57 68 None 0.1213 None 0.22 N 0.493 0.327 0.419461527279 gnomAD-4.0.0 6.84293E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99539E-07 0 0
A/S 7297 Ig-57 68 rs760654464 0.0842 -0.718 0.124 N 0.557 0.12 0.264081493735 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
A/S 7297 Ig-57 68 rs760654464 0.0842 -0.718 0.124 N 0.557 0.12 0.264081493735 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/S 7297 Ig-57 68 rs760654464 0.0842 -0.718 0.124 N 0.557 0.12 0.264081493735 gnomAD-4.0.0 8.67678E-06 None None None None N None 0 0 None 0 0 None 0 0 1.18676E-05 0 0
A/T 7297 Ig-57 68 rs760654464 0.0861 None 0.001 D 0.263 0.147 0.321108458156 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92604E-04 None 0 0 0 0 0
A/T 7297 Ig-57 68 rs760654464 0.0861 None 0.001 D 0.263 0.147 0.321108458156 gnomAD-4.0.0 6.57272E-06 None None None None N None 0 0 None 0 1.92604E-04 None 0 0 0 0 0
S/C 7486 Ig-59 68 rs879108235 0.1263 -0.832 0.99 D 0.504 0.469 None gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 5.59E-05 None 0 None 0 0 0
S/C 7582 Ig-60 68 rs768179623 0.18 -0.619 0.883 N 0.695 0.476 0.634587441147 gnomAD-2.1.1 2.41E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 4.45E-05 0
S/C 7582 Ig-60 68 rs768179623 0.18 -0.619 0.883 N 0.695 0.476 0.634587441147 gnomAD-4.0.0 1.02655E-05 None None None None N None 0 2.23634E-05 None 0 0 None 0 0 1.25953E-05 0 0
S/R 7676 Ig-61 69 rs199907920 0.6628 -0.284 0.86 N 0.561 0.332 0.15556083564 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.57E-05 0
S/R 7676 Ig-61 69 rs199907920 0.6628 -0.284 0.86 N 0.561 0.332 0.15556083564 gnomAD-4.0.0 4.79697E-06 None None None None N None 0 0 None 0 0 None 0 0 5.4058E-06 0 1.65931E-05
V/A 7769 Ig-62 68 None 0.0947 None 0.027 N 0.433 0.101 0.332902724076 gnomAD-4.0.0 1.36854E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79909E-06 0 0
V/F 7769 Ig-62 68 None 0.1367 None 0.188 N 0.587 0.154 0.279776271856 gnomAD-4.0.0 6.84269E-07 None None None None N None 0 0 None 0 2.51953E-05 None 0 0 0 0 0
V/I 7769 Ig-62 68 rs1553907172 0.0589 None None N 0.129 0.122 0.101711395817 gnomAD-4.0.0 2.05281E-06 None None None None N None 5.97836E-05 0 None 0 0 None 0 0 0 0 1.65684E-05
S/P 7863 Ig-63 69 rs1553906488 0.5527 None 0.794 D 0.56 0.463 0.259761712551 gnomAD-4.0.0 4.10585E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39739E-06 0 0
K/I 7956 Ig-64 68 rs1405929725 0.3543 None 0.642 N 0.549 0.28 0.561599553422 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/I 7956 Ig-64 68 rs1405929725 0.3543 None 0.642 N 0.549 0.28 0.561599553422 gnomAD-4.0.0 6.57393E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47024E-05 0 0
S/N 8145 Ig-66 68 rs1560647433 0.2352 None 0.896 N 0.518 0.271 0.278143212241 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
S/N 8145 Ig-66 68 rs1560647433 0.2352 None 0.896 N 0.518 0.271 0.278143212241 gnomAD-4.0.0 2.05264E-06 None None None None N None 0 2.23594E-05 None 0 0 None 0 0 1.79897E-06 0 0
Y/C 8238 Ig-67 68 rs202193812 0.1313 -0.381 0.958 N 0.456 0.261 0.690156929516 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66003E-04
Y/C 8238 Ig-67 68 rs202193812 0.1313 -0.381 0.958 N 0.456 0.261 0.690156929516 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Y/C 8238 Ig-67 68 rs202193812 0.1313 -0.381 0.958 N 0.456 0.261 0.690156929516 gnomAD-4.0.0 1.23938E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69527E-06 0 0
Y/F 8238 Ig-67 68 rs202193812 0.1114 None 0.68 N 0.493 0.153 0.483596354421 gnomAD-4.0.0 1.36844E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99494E-07 0 1.65656E-05
V/E 8331 Ig-68 68 rs773888026 0.1836 -1.278 0.064 N 0.544 0.235 0.55973633643 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
V/E 8331 Ig-68 68 rs773888026 0.1836 -1.278 0.064 N 0.544 0.235 0.55973633643 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
I/T 8427 Ig-69 68 rs2077682451 0.0606 None 0.003 N 0.284 0.128 0.348101942276 gnomAD-4.0.0 1.59243E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85989E-06 0 0
I/V 8427 Ig-69 68 rs748483075 0.0548 -0.298 None N 0.048 0.1 None gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.68E-05 0
I/V 8427 Ig-69 68 rs748483075 0.0548 -0.298 None N 0.048 0.1 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 8427 Ig-69 68 rs748483075 0.0548 -0.298 None N 0.048 0.1 None gnomAD-4.0.0 1.54967E-05 None None None None I None 0 0 None 0 0 None 0 0 2.11938E-05 0 0
A/T 8523 Ig-70 68 rs1288397933 0.0821 -0.663 0.021 N 0.36 0.096 0.269111216191 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
A/T 8523 Ig-70 68 rs1288397933 0.0821 -0.663 0.021 N 0.36 0.096 0.269111216191 gnomAD-4.0.0 1.23177E-05 None None None None N None 0 0 None 0 0 None 0 0 1.52928E-05 0 1.65722E-05
A/V 8523 Ig-70 68 rs1227310783 0.1319 -0.22 0.77 N 0.421 0.225 0.432154444652 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
A/V 8523 Ig-70 68 rs1227310783 0.1319 -0.22 0.77 N 0.421 0.225 0.432154444652 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
A/V 8523 Ig-70 68 rs1227310783 0.1319 -0.22 0.77 N 0.421 0.225 0.432154444652 gnomAD-4.0.0 3.09892E-06 None None None None N None 0 0 None 0 0 None 0 0 4.23859E-06 0 0
S/I 8617 Ig-71 69 None 0.4836 None 0.84 D 0.572 0.359 0.732098058403 gnomAD-4.0.0 1.5916E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85914E-06 0 0
S/N 8617 Ig-71 69 rs1361559046 0.3704 -0.497 0.001 N 0.198 0.173 0.213573922156 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
S/N 8617 Ig-71 69 rs1361559046 0.3704 -0.497 0.001 N 0.198 0.173 0.213573922156 gnomAD-4.0.0 6.36641E-06 None None None None N None 0 0 None 0 2.77316E-05 None 0 0 8.57741E-06 0 0
I/F 8710 Ig-72 68 None 0.1222 None 0.109 N 0.487 0.051 0.441844919209 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/L 8710 Ig-72 68 rs530696557 0.0974 -0.261 None N 0.259 0.055 0.373173300195 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
I/L 8710 Ig-72 68 rs530696557 0.0974 -0.261 None N 0.259 0.055 0.373173300195 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
I/M 8710 Ig-72 68 None 0.0768 None 0.001 N 0.281 0.081 0.188950314367 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/P 8804 Ig-73 69 rs778012263 0.5233 None 0.384 D 0.684 0.333 0.339074221408 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/P 8804 Ig-73 69 rs778012263 0.5233 None 0.384 D 0.684 0.333 0.339074221408 gnomAD-4.0.0 1.85913E-06 None None None None N None 0 0 None 0 0 None 0 0 2.5429E-06 0 0
A/S 8804 Ig-73 69 rs778012263 0.0896 -0.952 None N 0.348 0.05 0.18274738541 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/C 8897 Ig-74 68 None 0.1268 None 1.0 N 0.834 0.585 0.474168873855 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31253E-06 0 0
S/R 8993 Ig-75 68 rs1453136220 0.163 -0.282 0.033 N 0.536 0.173 0.0806252709748 gnomAD-2.1.1 4.42E-05 None None None None N None 0 0 None 0 0 None 3.59689E-04 None 0 0 0
S/R 8993 Ig-75 68 rs1453136220 0.163 -0.282 0.033 N 0.536 0.173 0.0806252709748 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 0 6.21375E-04 0
S/R 8993 Ig-75 68 rs1453136220 0.163 -0.282 0.033 N 0.536 0.173 0.0806252709748 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
S/R 8993 Ig-75 68 rs1453136220 0.163 -0.282 0.033 N 0.536 0.173 0.0806252709748 gnomAD-4.0.0 3.18282E-06 None None None None N None 0 0 None 0 0 None 0 0 5.7169E-06 0 0
S/C 9086 Ig-76 68 None 0.2065 None 0.99 D 0.507 0.495 0.453867917445 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/R 9086 Ig-76 68 None 0.4996 None 0.81 N 0.537 0.338 0.286465849087 gnomAD-4.0.0 6.84219E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99476E-07 0 0
A/V 9179 Ig-77 68 rs1377122264 0.1499 None 0.002 N 0.319 0.245 0.509996732195 gnomAD-4.0.0 8.89464E-06 None None None None N None 0 0 None 0 0 None 0 0 1.16928E-05 0 0
S/R 9272 Ig-78 68 None 0.42 None 0.001 N 0.299 0.3 0.250039746154 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
S/T 9272 Ig-78 68 rs763783812 0.079 -0.565 0.081 N 0.427 0.116 0.180583059064 gnomAD-2.1.1 2.81E-05 None None None None N None 0 0 None 0 0 None 1.96309E-04 None 0 8.87E-06 0
S/T 9272 Ig-78 68 rs763783812 0.079 -0.565 0.081 N 0.427 0.116 0.180583059064 gnomAD-4.0.0 1.43693E-05 None None None None N None 0 0 None 0 0 None 0 0 3.59809E-06 1.97179E-04 0
A/E 9368 Ig-79 68 rs1299434800 0.2224 -0.105 0.029 None 0.551 0.162 0.463243292966 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
A/E 9368 Ig-79 68 rs1299434800 0.2224 -0.105 0.029 None 0.551 0.162 0.463243292966 gnomAD-4.0.0 1.20032E-05 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-05 0 0
A/T 9561 Ig-81 69 rs373380202 0.1186 -1.258 0.97 None 0.457 0.2 None gnomAD-2.1.1 3.57E-05 None None None None N None 2.89352E-04 2.83E-05 None 0 0 None 0 None 0 7.79E-06 1.40213E-04
A/T 9561 Ig-81 69 rs373380202 0.1186 -1.258 0.97 None 0.457 0.2 None gnomAD-3.1.2 1.11697E-04 None None None None N None 3.6176E-04 1.30907E-04 0 0 0 None 0 0 0 0 0
A/T 9561 Ig-81 69 rs373380202 0.1186 -1.258 0.97 None 0.457 0.2 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
A/T 9561 Ig-81 69 rs373380202 0.1186 -1.258 0.97 None 0.457 0.2 None gnomAD-4.0.0 2.23061E-05 None None None None N None 2.79776E-04 4.99883E-05 None 0 2.22846E-05 None 0 0 3.39038E-06 1.09786E-05 9.604E-05
S/L 9657 Ig-82 68 rs200049911 0.1339 -0.006 0.271 None 0.539 0.386 None gnomAD-2.1.1 3.06869E-04 None None None None N None 2.97644E-03 1.13372E-04 None 0 0 None 2.94272E-04 None 0 7.8E-06 0
S/L 9657 Ig-82 68 rs200049911 0.1339 -0.006 0.271 None 0.539 0.386 None gnomAD-3.1.2 7.4262E-04 None None None None N None 2.60555E-03 1.96515E-04 0 0 0 None 0 0 1.47E-05 2.06868E-04 0
S/L 9657 Ig-82 68 rs200049911 0.1339 -0.006 0.271 None 0.539 0.386 None 1000 genomes 1.59744E-03 None None None None N None 5.3E-03 0 None None 0 0 None None None 1E-03 None
S/L 9657 Ig-82 68 rs200049911 0.1339 -0.006 0.271 None 0.539 0.386 None gnomAD-4.0.0 1.49335E-04 None None None None N None 2.61173E-03 1.33387E-04 None 0 0 None 0 0 2.54278E-06 3.07442E-04 9.6043E-05
S/T 9657 Ig-82 68 None 0.1055 None 0.027 None 0.483 0.106 0.143124449307 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
S/W 9657 Ig-82 68 None 0.5299 None 0.965 None 0.66 0.54 0.819072979398 gnomAD-4.0.0 6.84208E-07 None None None None N None 0 0 None 0 2.51902E-05 None 0 0 0 0 0
S/Y 9766 Ig-83 69 rs879033462 0.8641 None 0.999 None 0.824 0.526 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/L 9968 Ig-84 69 None 0.6226 None 0.98 None 0.587 0.511 0.531873083431 gnomAD-4.0.0 1.59195E-06 None None None None N None 0 2.2899E-05 None 0 0 None 0 0 0 0 0
Q/H 10055 Ig-85 67 rs1560511850 0.6083 None 0.939 None 0.491 0.256 0.288352970974 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 5.56E-05 None 0 None 0 0 0
Q/H 10055 Ig-85 67 rs1560511850 0.6083 None 0.939 None 0.491 0.256 0.288352970974 gnomAD-4.0.0 1.59092E-06 None None None None N None 0 0 None 0 2.77254E-05 None 0 0 0 0 0
E/K 10144 Ig-86 67 None 0.8741 None 0.999 None 0.581 0.377 0.478527412683 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/G 13753 Ig-87 70 rs1228071677 0.2588 None 0.896 N 0.509 0.331 0.473853734676 gnomAD-4.0.0 1.59229E-06 None None None None N None 0 2.28718E-05 None 0 0 None 0 0 0 0 0
A/S 13753 Ig-87 70 None 0.1198 None 0.64 N 0.579 0.103 0.340273420219 gnomAD-4.0.0 1.3688E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79925E-06 0 0
A/V 13847 Ig-88 68 rs1439068447 0.5055 -0.137 0.896 N 0.555 0.132 0.277317399466 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
A/V 13847 Ig-88 68 rs1439068447 0.5055 -0.137 0.896 N 0.555 0.132 0.277317399466 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/V 13847 Ig-88 68 rs1439068447 0.5055 -0.137 0.896 N 0.555 0.132 0.277317399466 gnomAD-4.0.0 1.05396E-05 None None None None N None 0 0 None 0 0 None 0 0 1.44145E-05 0 0
I/V 13942 Ig-89 67 rs902514647 0.0836 -0.902 None N 0.146 0.038 0.232513804876 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14732E-04 0 None 0 0 None 0 None 0 0 0
E/D 14119 Ig-91 66 None 0.6303 None 0.999 N 0.517 0.267 0.387202362727 gnomAD-4.0.0 1.59286E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02865E-05
I/T 14208 Ig-92 67 rs1391653235 0.189 -1.419 0.021 N 0.216 0.223 0.654688989383 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 1.78E-05 0
I/T 14208 Ig-92 67 rs1391653235 0.189 -1.419 0.021 N 0.216 0.223 0.654688989383 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
I/T 14208 Ig-92 67 rs1391653235 0.189 -1.419 0.021 N 0.216 0.223 0.654688989383 gnomAD-4.0.0 5.12602E-06 None None None None N None 0 0 None 0 0 None 0 0 7.18246E-06 1.34023E-05 0
I/V 14208 Ig-92 67 rs1447217875 0.1027 -1.209 0.675 N 0.303 0.204 0.53046153047 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/V 14208 Ig-92 67 rs1447217875 0.1027 -1.209 0.675 N 0.303 0.204 0.53046153047 gnomAD-4.0.0 1.59211E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43295E-05 0
K/E 14296 Ig-93 66 rs771834069 0.1671 0.007 0.767 N 0.282 0.233 0.326074293725 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
K/E 14296 Ig-93 66 rs771834069 0.1671 0.007 0.767 N 0.282 0.233 0.326074293725 gnomAD-4.0.0 3.18462E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71902E-06 0 0
K/N 14296 Ig-93 66 rs1272371985 0.4208 None 0.999 N 0.629 0.249 0.244539031024 gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
K/N 14296 Ig-93 66 rs1272371985 0.4208 None 0.999 N 0.629 0.249 0.244539031024 gnomAD-4.0.0 2.47947E-06 None None None None N None 5.34017E-05 0 None 0 0 None 0 0 0 0 0
T/K 14385 Ig-94 67 rs2059984757 0.493 None 0.995 N 0.71 0.319 0.280181792013 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/K 14385 Ig-94 67 rs2059984757 0.493 None 0.995 N 0.71 0.319 0.280181792013 gnomAD-4.0.0 2.03011E-06 None None None None N None 3.49491E-05 0 None 0 0 None 0 0 0 0 0
T/R 14385 Ig-94 67 None 0.3992 None 0.998 N 0.809 0.341 0.323615622048 gnomAD-4.0.0 2.40064E-06 None None None None N None 1.26695E-04 0 None 0 0 None 0 0 0 0 0
E/D 14474 Ig-95 67 rs998106657 0.778 -0.504 0.999 D 0.499 0.311 0.308904156042 gnomAD-2.1.1 8.06E-06 None None None None N None 1.29282E-04 0 None 0 0 None 0 None 0 0 0
E/D 14474 Ig-95 67 rs998106657 0.778 -0.504 0.999 D 0.499 0.311 0.308904156042 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
E/D 14474 Ig-95 67 rs998106657 0.778 -0.504 0.999 D 0.499 0.311 0.308904156042 gnomAD-4.0.0 6.84393E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99638E-07 0 0
T/I 14563 Ig-96 67 rs778681205 0.4878 -0.306 1.0 N 0.851 0.415 0.519187973786 gnomAD-2.1.1 4.17E-06 None None None None N None 0 0 None 0 0 None 3.41E-05 None 0 0 0
T/I 14563 Ig-96 67 rs778681205 0.4878 -0.306 1.0 N 0.851 0.415 0.519187973786 gnomAD-4.0.0 5.49271E-06 None None None None N None 0 0 None 0 0 None 0 0 6.31032E-06 1.17242E-05 0
I/S 14652 Ig-97 67 rs767038885 0.1805 -0.484 0.681 N 0.411 0.218 0.694585858326 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
I/S 14652 Ig-97 67 rs767038885 0.1805 -0.484 0.681 N 0.411 0.218 0.694585858326 gnomAD-4.0.0 2.73755E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59835E-06 0 0
I/T 14652 Ig-97 67 rs767038885 0.0721 -0.463 0.912 N 0.483 0.23 0.674560721455 gnomAD-2.1.1 8.05E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.9E-06 0
I/T 14652 Ig-97 67 rs767038885 0.0721 -0.463 0.912 N 0.483 0.23 0.674560721455 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/T 14652 Ig-97 67 rs767038885 0.0721 -0.463 0.912 N 0.483 0.23 0.674560721455 gnomAD-4.0.0 4.33924E-06 None None None None N None 0 1.66822E-05 None 0 0 None 0 0 5.08641E-06 0 0
T/A 14741 Ig-98 67 rs745305661 0.0732 -0.867 None N 0.143 0.045 0.0611884634855 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.61E-05 None 0 None 0 0 0
T/A 14741 Ig-98 67 rs745305661 0.0732 -0.867 None N 0.143 0.045 0.0611884634855 gnomAD-4.0.0 1.59272E-06 None None None None N None 0 0 None 0 2.78272E-05 None 0 0 0 0 0
T/M 14741 Ig-98 67 rs778576436 0.123 0.077 0.996 N 0.485 0.314 0.285698343383 gnomAD-2.1.1 2.41E-05 None None None None N None 0 2.9E-05 None 0 0 None 9.81E-05 None 0 1.78E-05 0
T/M 14741 Ig-98 67 rs778576436 0.123 0.077 0.996 N 0.485 0.314 0.285698343383 gnomAD-4.0.0 2.0535E-05 None None None None N None 1.79501E-04 2.23754E-05 None 0 0 None 0 0 1.52954E-05 4.63919E-05 3.31488E-05
A/T 14830 Ig-99 66 rs1355448697 0.1778 -0.079 0.999 N 0.669 0.302 0.513674172182 gnomAD-2.1.1 8.34E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.82E-05 0
A/T 14830 Ig-99 66 rs1355448697 0.1778 -0.079 0.999 N 0.669 0.302 0.513674172182 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
A/T 14830 Ig-99 66 rs1355448697 0.1778 -0.079 0.999 N 0.669 0.302 0.513674172182 gnomAD-4.0.0 7.78756E-06 None None None None N None 0 0 None 0 0 None 0 0 1.45066E-05 0 0
I/M 14919 Ig-100 67 None 0.118 None 0.975 N 0.457 0.267 0.530803083455 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
A/G 15097 Ig-102 67 None 0.1581 None 0.645 D 0.475 0.446 0.435808882951 gnomAD-4.0.0 6.84701E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99936E-07 0 0
A/V 15097 Ig-102 67 rs555033060 0.1376 None 0.024 D 0.249 0.366 0.523133305157 gnomAD-4.0.0 6.84701E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99936E-07 0 0
M/T 15186 Ig-103 67 rs878910401 0.1328 None 0.002 N 0.127 0.257 None gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
E/A 15368 Ig-105 67 None 0.4414 None 0.999 N 0.684 0.553 0.464442853059 gnomAD-4.0.0 1.59442E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86418E-06 0 0
E/K 15368 Ig-105 67 None 0.5422 None 0.999 D 0.591 0.445 0.479893544335 gnomAD-4.0.0 1.59446E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86428E-06 0 0
E/D 15457 Ig-106 67 rs764100235 0.7652 -0.725 0.999 N 0.472 0.331 0.238096912614 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.98E-06 0
E/D 15457 Ig-106 67 rs764100235 0.7652 -0.725 0.999 N 0.472 0.331 0.238096912614 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/D 15457 Ig-106 67 rs764100235 0.7652 -0.725 0.999 N 0.472 0.331 0.238096912614 gnomAD-4.0.0 1.86118E-06 None None None None N None 0 0 None 0 0 None 0 0 2.5449E-06 0 0
E/K 15457 Ig-106 67 rs753664074 0.7839 -0.357 0.999 N 0.573 0.436 0.487208542674 gnomAD-2.1.1 4.45E-05 None None None None N None 0 2.6207E-04 None 0 0 None 0 None 0 1.8E-05 0
E/K 15457 Ig-106 67 rs753664074 0.7839 -0.357 0.999 N 0.573 0.436 0.487208542674 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 15457 Ig-106 67 rs753664074 0.7839 -0.357 0.999 N 0.573 0.436 0.487208542674 gnomAD-4.0.0 1.24077E-05 None None None None N None 0 1.83897E-04 None 0 0 None 0 0 5.9381E-06 0 3.20698E-05
Q/E 15546 Ig-107 67 None 0.1589 None 0.992 N 0.333 0.319 0.433491693731 gnomAD-4.0.0 1.59456E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86472E-06 0 0
Q/H 15546 Ig-107 67 None 0.6816 None 0.999 N 0.632 0.292 0.486567385682 gnomAD-4.0.0 1.59453E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4341E-05 0
Q/P 15546 Ig-107 67 rs2057979047 0.886 None 0.999 N 0.757 0.59 0.476364732183 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.57E-05 0 0 0 None 0 0 0 0 0
Q/P 15546 Ig-107 67 rs2057979047 0.886 None 0.999 N 0.757 0.59 0.476364732183 gnomAD-4.0.0 6.58354E-06 None None None None N None 0 6.57203E-05 None 0 0 None 0 0 0 0 0
K/E 16030 Ig-109 63 rs764470678 0.2921 0.281 0.767 N 0.271 0.175 0.307648195649 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
K/E 16030 Ig-109 63 rs764470678 0.2921 0.281 0.767 N 0.271 0.175 0.307648195649 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/R 16030 Ig-109 63 rs1262384504 0.0896 -0.284 0.996 N 0.451 0.284 0.51098835382 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66279E-04
K/R 16030 Ig-109 63 rs1262384504 0.0896 -0.284 0.996 N 0.451 0.284 0.51098835382 gnomAD-4.0.0 3.18655E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 6.05877E-05
T/A 16326 Ig-110 65 rs1247538583 0.1408 -0.814 0.349 N 0.431 0.14 0.156986980423 gnomAD-2.1.1 8.07E-06 None None None None N None 0 5.82E-05 None 0 0 None 0 None 0 0 0
T/A 16326 Ig-110 65 rs1247538583 0.1408 -0.814 0.349 N 0.431 0.14 0.156986980423 gnomAD-4.0.0 3.18818E-06 None None None None N None 0 4.58169E-05 None 0 0 None 0 0 0 0 0
A/D 17022 Ig-111 68 rs372419267 0.6066 None 0.946 D 0.869 0.431 0.71113996826 gnomAD-4.0.0 8.215E-06 None None None None N None 2.9933E-05 0 None 0 0 None 0 0 9.89873E-06 0 0
A/V 17022 Ig-111 68 rs372419267 0.2847 -0.501 0.911 D 0.633 0.398 None gnomAD-2.1.1 1.07213E-04 None None None None N None 9.93377E-04 1.41587E-04 None 0 0 None 0 None 0 0 1.40449E-04
A/V 17022 Ig-111 68 rs372419267 0.2847 -0.501 0.911 D 0.633 0.398 None gnomAD-3.1.2 4.14632E-04 None None None None N None 1.42436E-03 1.31251E-04 0 0 0 None 0 0 1.47E-05 0 4.79386E-04
A/V 17022 Ig-111 68 rs372419267 0.2847 -0.501 0.911 D 0.633 0.398 None gnomAD-4.0.0 6.94444E-05 None None None None N None 1.3075E-03 1.16756E-04 None 0 0 None 1.5623E-05 0 1.69609E-06 0 6.408E-05
H/Q 17344 Ig-112 94 None 0.3373 None 0.995 D 0.605 0.277 0.365120060079 gnomAD-4.0.0 6.98497E-07 None None None None N None 0 0 None 4.18585E-05 0 None 0 0 0 0 0
H/R 17344 Ig-112 94 rs748445315 0.1966 -0.503 0.984 N 0.599 0.518 0.373715746628 gnomAD-2.1.1 1.79E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.89E-05 0
H/R 17344 Ig-112 94 rs748445315 0.1966 -0.503 0.984 N 0.599 0.518 0.373715746628 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.42E-05 0 0
H/R 17344 Ig-112 94 rs748445315 0.1966 -0.503 0.984 N 0.599 0.518 0.373715746628 gnomAD-4.0.0 2.20971E-05 None None None None N None 1.35435E-05 0 None 0 0 None 0 0 2.91533E-05 0 0
H/Y 17344 Ig-112 94 rs770072826 0.1845 0.947 0.026 D 0.246 0.24 0.252162846088 gnomAD-2.1.1 1.34E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.91E-05 0
H/Y 17344 Ig-112 94 rs770072826 0.1845 0.947 0.026 D 0.246 0.24 0.252162846088 gnomAD-4.0.0 6.65885E-06 None None None None N None 0 0 None 0 0 None 0 0 8.89991E-06 0 3.14051E-05
H/L 17739 Ig-113 63 None 0.356 None 0.959 N 0.515 0.294 0.663800828988 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/N 17739 Ig-113 63 rs1419607621 0.1901 0.145 0.959 N 0.478 0.297 0.280181792013 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
H/N 17739 Ig-113 63 rs1419607621 0.1901 0.145 0.959 N 0.478 0.297 0.280181792013 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
H/N 17739 Ig-113 63 rs1419607621 0.1901 0.145 0.959 N 0.478 0.297 0.280181792013 gnomAD-4.0.0 7.69235E-06 None None None None N None 0 0 None 0 0 None 0 0 1.43707E-05 0 0
H/R 17739 Ig-113 63 rs1488100561 0.2276 None 0.979 N 0.533 0.325 0.281780670237 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
H/R 17739 Ig-113 63 rs1488100561 0.2276 None 0.979 N 0.533 0.325 0.281780670237 gnomAD-4.0.0 6.57722E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47171E-05 0 0
K/E 18040 Ig-114 73 rs1465644822 0.3217 0.013 0.959 N 0.488 0.221 0.350964488264 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
K/E 18040 Ig-114 73 rs1465644822 0.3217 0.013 0.959 N 0.488 0.221 0.350964488264 gnomAD-4.0.0 1.36952E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80004E-06 0 0
K/R 18040 Ig-114 73 None 0.0853 None 0.03 N 0.106 0.128 0.267299060538 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
T/A 18454 Ig-115 73 None 0.0913 None 0.002 N 0.253 0.066 0.0920862733494 gnomAD-4.0.0 6.85952E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00361E-07 0 0
T/I 18454 Ig-115 73 rs1171368715 0.526 -0.195 0.055 N 0.502 0.204 0.30921473904 gnomAD-2.1.1 4.08E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.98E-06 0
T/I 18454 Ig-115 73 rs1171368715 0.526 -0.195 0.055 N 0.502 0.204 0.30921473904 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
T/I 18454 Ig-115 73 rs1171368715 0.526 -0.195 0.055 N 0.502 0.204 0.30921473904 gnomAD-4.0.0 1.92576E-05 None None None None I None 0 0 None 0 0 None 0 0 2.54535E-05 0 1.6056E-05
T/R 18454 Ig-115 73 None 0.4496 None 0.055 N 0.499 0.182 0.343334270461 gnomAD-4.0.0 6.8599E-07 None None None None I None 0 0 None 0 0 None 0 0 9.0038E-07 0 0
T/P 18759 Ig-116 72 None 0.7417 None 0.994 N 0.655 0.584 0.46123363591 gnomAD-4.0.0 1.5952E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8642E-06 0 0
S/P 19454 Ig-118 64 None 0.9287 None 0.991 D 0.795 0.629 0.382761230579 gnomAD-4.0.0 1.59175E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85907E-06 0 0
G/S 19852 Ig-119 63 rs746700153 0.1083 -0.384 0.885 N 0.481 0.241 0.267299060538 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
G/S 19852 Ig-119 63 rs746700153 0.1083 -0.384 0.885 N 0.481 0.241 0.267299060538 gnomAD-4.0.0 2.05299E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79918E-06 1.15964E-05 0
H/L 20544 Ig-121 66 None 0.5236 None 0.961 N 0.59 0.41 0.548865971634 gnomAD-4.0.0 6.84426E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99672E-07 0 0
H/R 20544 Ig-121 66 rs876658073 0.4169 -0.368 0.999 N 0.508 0.367 None gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
H/R 20544 Ig-121 66 rs876658073 0.4169 -0.368 0.999 N 0.508 0.367 None gnomAD-4.0.0 2.7377E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59869E-06 0 0
S/G 21534 Ig-124 66 rs768431801 0.1235 -1.263 0.939 N 0.437 0.272 0.341226946553 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
A/E 22329 Ig-126 65 rs2047425169 0.8309 None 0.988 D 0.742 0.519 0.681754529401 gnomAD-4.0.0 6.84446E-07 None None None None I None 2.99079E-05 0 None 0 0 None 0 0 0 0 0
A/S 22329 Ig-126 65 rs886055253 0.1296 -1.047 0.414 N 0.367 0.104 0.207176502487 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
A/S 22329 Ig-126 65 rs886055253 0.1296 -1.047 0.414 N 0.367 0.104 0.207176502487 gnomAD-4.0.0 6.84437E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99708E-07 0 0
A/T 22329 Ig-126 65 rs886055253 0.2138 -0.908 0.919 D 0.576 0.279 0.373173300195 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
A/T 22329 Ig-126 65 rs886055253 0.2138 -0.908 0.919 D 0.576 0.279 0.373173300195 gnomAD-4.0.0 5.4755E-06 None None None None I None 0 0 None 0 0 None 0 0 7.19766E-06 0 0
A/T 22618 Ig-127 59 None 0.1178 None 1.0 N 0.726 0.414 0.414798848334 gnomAD-4.0.0 1.59182E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85945E-06 0 0
A/P 23015 Ig-128 66 rs1416377694 0.8072 None 0.815 N 0.484 0.465 None gnomAD-4.0.0 4.10637E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39778E-06 0 0
A/T 23015 Ig-128 66 None 0.0786 None 0.001 N 0.116 0.1 0.27855597813 gnomAD-4.0.0 6.84395E-07 None None None None N None 0 0 None 0 2.5264E-05 None 0 0 0 0 0
A/V 23015 Ig-128 66 rs771710562 0.2072 -0.388 0.716 N 0.477 0.346 None gnomAD-2.1.1 4.29E-05 None None None None N None 0 0 None 0 5.17E-05 None 0 None 0 8.61E-05 0
A/V 23015 Ig-128 66 rs771710562 0.2072 -0.388 0.716 N 0.477 0.346 None gnomAD-3.1.2 3.3E-05 None None None None N None 7.29E-05 0 0 0 0 None 0 0 2.95E-05 0 0
A/V 23015 Ig-128 66 rs771710562 0.2072 -0.388 0.716 N 0.477 0.346 None gnomAD-4.0.0 3.65904E-05 None None None None N None 4.02005E-05 1.67185E-05 None 0 0 None 1.56529E-05 0 4.23939E-05 3.29649E-05 1.60256E-05
T/N 23410 Ig-129 66 rs1473979874 0.2426 -0.468 0.491 N 0.437 0.334 0.337868961071 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
T/N 23410 Ig-129 66 rs1473979874 0.2426 -0.468 0.491 N 0.437 0.334 0.337868961071 gnomAD-4.0.0 1.36855E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79914E-06 0 0
S/N 24097 Ig-131 69 None 0.3509 None 0.117 N 0.532 0.287 0.251639045875 gnomAD-4.0.0 2.05543E-06 None None None None N None 0 0 None 0 0 None 0 1.73732E-04 9.00575E-07 0 1.65898E-05
S/G 24494 Ig-132 64 None 0.1236 None 0.001 N 0.12 0.156 0.212008924253 gnomAD-4.0.0 3.18607E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43472E-05 3.027E-05
S/T 24494 Ig-132 64 rs767397034 0.1222 -0.561 0.684 N 0.466 0.156 None gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
S/T 24494 Ig-132 64 rs767397034 0.1222 -0.561 0.684 N 0.466 0.156 None gnomAD-4.0.0 2.73831E-06 None None None None I None 0 0 None 0 0 None 0 3.47584E-04 1.79963E-06 0 0
S/G 25179 Ig-134 69 None 0.0652 None 0.001 N 0.099 0.112 0.240491677333 gnomAD-4.0.0 1.59201E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8593E-06 0 0
S/I 25179 Ig-134 69 rs1707825779 0.6582 None 0.939 N 0.551 0.59 0.610263417295 gnomAD-4.0.0 1.59203E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85928E-06 0 0
S/T 25179 Ig-134 69 rs1707825779 0.1031 None 0.815 D 0.429 0.252 0.335661160332 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/T 25179 Ig-134 69 rs1707825779 0.1031 None 0.815 D 0.429 0.252 0.335661160332 gnomAD-4.0.0 6.57428E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47067E-05 0 0
S/N 25576 Ig-135 63 rs1184700085 0.4434 None 0.334 N 0.501 0.218 0.230578612272 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/N 25576 Ig-135 63 rs1184700085 0.4434 None 0.334 N 0.501 0.218 0.230578612272 gnomAD-4.0.0 6.57678E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47072E-05 0 0
S/R 25576 Ig-135 63 None 0.9075 None 0.638 N 0.719 0.357 0.35139820857 gnomAD-4.0.0 1.59225E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85966E-06 0 0
S/T 25576 Ig-135 63 None 0.0846 None 0.001 N 0.223 0.138 0.18274738541 gnomAD-4.0.0 1.32035E-05 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-05 0 3.66327E-05
G/D 25865 Ig-136 68 rs756930121 0.3952 -0.047 0.001 N 0.353 0.139 0.218112801441 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 5.58E-05 None 3.27E-05 None 0 0 0
G/D 25865 Ig-136 68 rs756930121 0.3952 -0.047 0.001 N 0.353 0.139 0.218112801441 gnomAD-4.0.0 3.18384E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43295E-05 3.02645E-05
G/S 25865 Ig-136 68 None 0.0693 None 0.001 N 0.239 0.09 0.126345400529 gnomAD-4.0.0 3.42169E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49807E-06 0 0
G/C 26261 Ig-137 69 rs1179223519 0.3925 -0.64 1.0 N 0.821 0.505 0.739630067429 gnomAD-2.1.1 4.33E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.36E-06 0
G/C 26261 Ig-137 69 rs1179223519 0.3925 -0.64 1.0 N 0.821 0.505 0.739630067429 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
G/C 26261 Ig-137 69 rs1179223519 0.3925 -0.64 1.0 N 0.821 0.505 0.739630067429 gnomAD-4.0.0 3.92673E-06 None None None None I None 0 0 None 0 0 None 0 0 7.28046E-06 0 0
G/D 26261 Ig-137 69 None 0.8592 None 0.996 D 0.855 0.491 0.40749426699 gnomAD-4.0.0 4.84215E-06 None None None None I None 0 0 None 0 0 None 0 0 4.5203E-06 0 3.35672E-05
G/R 27344 Ig-140 67 None 0.4945 None 1.0 N 0.904 0.38 0.633221168995 gnomAD-4.0.0 2.05265E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69852E-06 0 0
S/G 27741 Ig-141 66 rs1368077967 0.1799 -1.222 0.98 D 0.555 0.425 0.324436698001 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/G 27741 Ig-141 66 rs1368077967 0.1799 -1.222 0.98 D 0.555 0.425 0.324436698001 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
S/G 27741 Ig-141 66 rs1368077967 0.1799 -1.222 0.98 D 0.555 0.425 0.324436698001 gnomAD-4.0.0 5.12601E-06 None None None None I None 0 0 None 0 0 None 0 0 0 5.36049E-05 0
S/N 27741 Ig-141 66 None 0.661 None 0.98 N 0.535 0.307 0.32082282376 gnomAD-4.0.0 1.59189E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
S/R 27741 Ig-141 66 rs1368077967 0.9767 None 0.994 N 0.651 0.578 0.401612077098 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.9305E-04 None 0 0 0 0 0
S/R 27741 Ig-141 66 rs1368077967 0.9767 None 0.994 N 0.651 0.578 0.401612077098 gnomAD-4.0.0 6.40751E-06 None None None None I None 0 0 None 0 9.72621E-05 None 0 0 0 0 2.8456E-05
T/A 28425 Ig-143 68 None 0.092 None 0.012 N 0.258 0.079 0.0806252709748 gnomAD-4.0.0 6.00161E-06 None None None None I None 0 0 None 0 0 None 0 0 6.56251E-06 0 0
S/C 28820 Ig-144 66 rs1212262872 0.1792 -0.631 0.995 N 0.749 0.521 0.595157249553 gnomAD-2.1.1 4.06E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
S/C 28820 Ig-144 66 rs1212262872 0.1792 -0.631 0.995 N 0.749 0.521 0.595157249553 gnomAD-4.0.0 1.59634E-06 None None None None N None 5.67666E-05 0 None 0 0 None 0 0 0 0 0
A/S 29112 Ig-145 68 rs895853838 0.1002 -1.32 0.014 N 0.263 0.043 0.184867976434 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
A/S 29112 Ig-145 68 rs895853838 0.1002 -1.32 0.014 N 0.263 0.043 0.184867976434 gnomAD-4.0.0 6.84189E-07 None None None None N None 0 2.23594E-05 None 0 0 None 0 0 0 0 0
A/T 29112 Ig-145 68 rs895853838 0.1004 -1.214 0.121 N 0.321 0.104 0.259761712551 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
A/T 29112 Ig-145 68 rs895853838 0.1004 -1.214 0.121 N 0.321 0.104 0.259761712551 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
A/T 29112 Ig-145 68 rs895853838 0.1004 -1.214 0.121 N 0.321 0.104 0.259761712551 gnomAD-4.0.0 1.05344E-05 None None None None N None 0 1.66667E-05 None 0 2.22797E-05 None 0 0 1.01707E-05 2.19573E-05 1.60102E-05
S/N 29508 Ig-146 65 rs1314571330 0.3544 -0.367 0.989 N 0.535 0.29 0.301455362545 gnomAD-2.1.1 3.62E-05 None None None None N None 0 2.03004E-04 None 0 0 None 0 None 0 1.78E-05 0
S/N 29508 Ig-146 65 rs1314571330 0.3544 -0.367 0.989 N 0.535 0.29 0.301455362545 gnomAD-3.1.2 3.29E-05 None None None None N None 0 3.27397E-04 0 0 0 None 0 0 0 0 0
S/N 29508 Ig-146 65 rs1314571330 0.3544 -0.367 0.989 N 0.535 0.29 0.301455362545 gnomAD-4.0.0 1.73511E-05 None None None None N None 0 2.00027E-04 None 0 2.23105E-05 None 0 0 1.10184E-05 0 3.20215E-05
S/T 29508 Ig-146 65 None 0.0983 None 0.198 N 0.247 0.162 0.193865811164 gnomAD-4.0.0 6.84212E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99433E-07 0 0
T/I 29907 Ig-147 66 rs762852359 0.5769 -0.25 0.997 N 0.659 0.351 0.532938547298 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 1.65673E-04
T/I 29907 Ig-147 66 rs762852359 0.5769 -0.25 0.997 N 0.659 0.351 0.532938547298 gnomAD-4.0.0 7.95626E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57417E-06 2.8659E-05 0
G/E 30199 Ig-148 68 rs757271306 0.4209 -0.127 0.994 N 0.668 0.358 0.39798585902 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 5.58E-05 None 0 None 0 0 0
G/E 30199 Ig-148 68 rs757271306 0.4209 -0.127 0.994 N 0.668 0.358 0.39798585902 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92901E-04 None 0 0 0 0 0
G/E 30199 Ig-148 68 rs757271306 0.4209 -0.127 0.994 N 0.668 0.358 0.39798585902 gnomAD-4.0.0 2.02988E-06 None None None None I None 0 0 None 0 2.26912E-04 None 0 0 0 0 0
G/R 30199 Ig-148 68 None 0.4634 None 0.997 N 0.75 0.338 0.404034981753 gnomAD-4.0.0 3.18963E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.88342E-05 0
R/C 30594 Ig-149 63 rs1399257168 0.1377 -0.368 0.987 D 0.705 0.451 0.6184965563 gnomAD-2.1.1 6.37E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.29584E-04 0
R/C 30594 Ig-149 63 rs1399257168 0.1377 -0.368 0.987 D 0.705 0.451 0.6184965563 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/C 30594 Ig-149 63 rs1399257168 0.1377 -0.368 0.987 D 0.705 0.451 0.6184965563 gnomAD-4.0.0 6.19732E-06 None None None None N None 1.33551E-05 0 None 0 0 None 0 0 6.78106E-06 1.09791E-05 0
R/H 30594 Ig-149 63 rs759363893 0.1121 -1.164 0.953 N 0.652 0.331 0.381916209588 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
R/H 30594 Ig-149 63 rs759363893 0.1121 -1.164 0.953 N 0.652 0.331 0.381916209588 gnomAD-4.0.0 8.89506E-06 None None None None N None 0 0 None 0 2.51953E-05 None 0 0 7.19602E-06 4.63779E-05 0
A/V 30991 Ig-150 65 None 0.3867 None 0.992 N 0.49 0.493 0.604839314244 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
S/Y 31283 Ig-151 66 None 0.5839 None 0.999 N 0.812 0.548 0.785898684871 gnomAD-4.0.0 1.59103E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85773E-06 0 0
S/G 31683 Ig-152 63 rs72648257 0.1023 -1.243 0.98 D 0.57 0.282 None gnomAD-2.1.1 2.57578E-02 None None None None N None 4.83671E-03 3.37746E-02 None 1.45978E-02 6.12193E-02 None 6.1458E-03 None 4.79047E-02 2.33092E-02 2.65226E-02
S/G 31683 Ig-152 63 rs72648257 0.1023 -1.243 0.98 D 0.57 0.282 None gnomAD-3.1.2 2.02147E-02 None None None None N None 4.4869E-03 2.18501E-02 3.07018E-02 1.90311E-02 6.0717E-02 None 4.46849E-02 6.32911E-03 2.34001E-02 8.06452E-03 1.91205E-02
S/G 31683 Ig-152 63 rs72648257 0.1023 -1.243 0.98 D 0.57 0.282 None 1000 genomes 2.23642E-02 None None None None N None 8E-04 2.45E-02 None None 6.05E-02 2.68E-02 None None None 6.1E-03 None
S/G 31683 Ig-152 63 rs72648257 0.1023 -1.243 0.98 D 0.57 0.282 None gnomAD-4.0.0 2.28999E-02 None None None None N None 4.30391E-03 2.95539E-02 None 1.48659E-02 6.30711E-02 None 4.76681E-02 9.74562E-03 2.24418E-02 6.79667E-03 2.17029E-02
S/R 31683 Ig-152 63 rs1697090717 0.8603 None 0.994 N 0.618 0.489 0.409533910539 gnomAD-4.0.0 6.8422E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99493E-07 0 0
A/T 32080 Ig-153 64 None 0.1824 None 0.992 N 0.5 0.291 0.375861065471 gnomAD-4.0.0 1.36849E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79904E-06 0 0
A/V 32080 Ig-153 64 None 0.4648 None 0.998 N 0.585 0.429 0.69178495124 gnomAD-4.0.0 1.20033E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
S/C 32770 Ig-155 63 rs760728887 0.1632 -0.611 0.999 N 0.712 0.466 0.501247319706 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
S/C 32770 Ig-155 63 rs760728887 0.1632 -0.611 0.999 N 0.712 0.466 0.501247319706 gnomAD-4.0.0 1.59118E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85822E-06 0 0
A/T 33265 Ig-157 63 None 0.1199 None 0.631 N 0.335 0.12 0.212008924253 gnomAD-4.0.0 6.8572E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01297E-07 0 0
A/P 33565 Ig-158 70 rs373484505 0.9528 None 0.974 N 0.724 0.497 None gnomAD-4.0.0 1.24647E-05 None None None None N None 0 0 None 0 0 None 0 0 1.63503E-05 0 0
A/T 33565 Ig-158 70 rs373484505 0.204 None 0.63 N 0.461 0.176 0.395894371353 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92678E-04 None 0 0 0 0 0
A/T 33565 Ig-158 70 rs373484505 0.204 None 0.63 N 0.461 0.176 0.395894371353 gnomAD-4.0.0 1.87944E-06 None None None None N None 0 0 None 0 6.71081E-05 None 0 0 0 0 0
A/V 33565 Ig-158 70 rs1691364591 0.4373 None 0.05 D 0.282 0.225 0.398133443147 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/V 33565 Ig-158 70 rs1691364591 0.4373 None 0.05 D 0.282 0.225 0.398133443147 gnomAD-4.0.0 1.25329E-06 None None None None N None 0 0 None 0 0 None 0 0 1.71146E-06 0 0
A/D 33664 Ig-159 69 None 0.8022 None 0.946 D 0.66 0.394 0.577897453458 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/E 34204 Ig-160 68 rs2154135586 0.884 None 0.989 N 0.458 0.225 0.330589388543 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
D/G 34204 Ig-160 68 None 0.8732 None 0.117 N 0.379 0.325 0.306053231325 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
D/N 34204 Ig-160 68 rs778105940 0.5905 -1.106 0.993 N 0.672 0.413 0.422040124859 gnomAD-2.1.1 1.61E-05 None None None None N None 0 8.7E-05 None 0 0 None 0 None 0 0 1.65399E-04
D/N 34204 Ig-160 68 rs778105940 0.5905 -1.106 0.993 N 0.672 0.413 0.422040124859 gnomAD-4.0.0 3.18207E-06 None None None None N None 0 4.57352E-05 None 0 0 None 0 0 0 0 0
D/E 34328 Ig-161 71 rs541125667 0.2393 -0.732 0.008 N 0.251 0.033 0.0551355673512 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
D/E 34328 Ig-161 71 rs541125667 0.2393 -0.732 0.008 N 0.251 0.033 0.0551355673512 gnomAD-4.0.0 2.0525E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69823E-06 0 0
T/M 34431 Ig-162 69 rs192001910 0.2237 0.153 0.998 N 0.579 0.246 None gnomAD-2.1.1 6.45843E-04 None None None None N None 1.65303E-04 7.63661E-04 None 1.73913E-03 0 None 0 None 4.01E-05 9.67556E-04 9.81217E-04
T/M 34431 Ig-162 69 rs192001910 0.2237 0.153 0.998 N 0.579 0.246 None gnomAD-3.1.2 5.65232E-04 None None None None N None 2.41418E-04 4.58355E-04 0 1.1534E-03 0 None 0 0 9.25953E-04 0 9.5511E-04
T/M 34431 Ig-162 69 rs192001910 0.2237 0.153 0.998 N 0.579 0.246 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
T/M 34431 Ig-162 69 rs192001910 0.2237 0.153 0.998 N 0.579 0.246 None gnomAD-4.0.0 9.15868E-04 None None None None N None 1.59953E-04 6.49892E-04 None 1.41873E-03 0 None 0 0 1.13065E-03 4.39145E-05 7.52193E-04
T/R 34431 Ig-162 69 rs192001910 0.3469 None 0.911 N 0.591 0.215 0.407632638399 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/R 34431 Ig-162 69 rs192001910 0.3469 None 0.911 N 0.591 0.215 0.407632638399 gnomAD-4.0.0 3.09856E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39022E-06 0 1.60097E-05
S/G 35009 Ig-163 68 rs1689133557 0.1387 None 0.001 N 0.181 0.143 0.232513804876 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.30856E-04 0 0 0 None 0 0 0 0 0
S/G 35009 Ig-163 68 rs1689133557 0.1387 None 0.001 N 0.181 0.143 0.232513804876 gnomAD-4.0.0 1.31403E-05 None None None None N None 0 1.30856E-04 None 0 0 None 0 0 0 0 0
S/I 35009 Ig-163 68 None 0.5155 None 0.497 N 0.725 0.438 0.521653710555 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.21507E-04 0
Q/R 35354 Ig-165 69 rs546343124 0.0794 -0.059 None N 0.129 0.105 0.0482279557977 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 2.78211E-04 None 0 None 0 0 0
Q/R 35354 Ig-165 69 rs546343124 0.0794 -0.059 None N 0.129 0.105 0.0482279557977 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 5.76923E-04 None 0 0 0 0 0
Q/R 35354 Ig-165 69 rs546343124 0.0794 -0.059 None N 0.129 0.105 0.0482279557977 1000 genomes 5.99042E-04 None None None None N None 0 0 None None 3E-03 0 None None None 0 None
Q/R 35354 Ig-165 69 rs546343124 0.0794 -0.059 None N 0.129 0.105 0.0482279557977 gnomAD-4.0.0 6.40292E-06 None None None None N None 0 0 None 0 1.21194E-04 None 0 0 0 0 0
E/D 35672 Ig-167 66 rs753906444 0.4359 -0.663 0.822 N 0.471 0.072 0.190952846119 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
E/D 35672 Ig-167 66 rs753906444 0.4359 -0.663 0.822 N 0.471 0.072 0.190952846119 gnomAD-4.0.0 1.59256E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4339E-05 0
E/K 35672 Ig-167 66 None 0.136 None 0.698 N 0.513 0.116 0.29385284311 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
S/R 35769 Ig-168 68 None 0.865 None 0.934 N 0.481 0.437 0.346992582518 gnomAD-4.0.0 4.10499E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49711E-06 0 1.6564E-05
G/D 35966 Ig-169 70 rs727505008 0.5565 -0.264 0.997 N 0.777 0.363 0.347217280506 gnomAD-2.1.1 8.03E-06 None None None -0.169(OBSL1) 0.119(OBSCN) N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
G/D 35966 Ig-169 70 rs727505008 0.5565 -0.264 0.997 N 0.777 0.363 0.347217280506 gnomAD-4.0.0 1.36832E-05 None None None -0.169(OBSL1) 0.119(OBSCN) N None 0 0 None 0 0 None 0 0 1.61894E-05 1.15942E-05 1.6564E-05
G/S 35966 Ig-169 70 rs541322681 0.1169 -0.735 0.955 N 0.433 0.339 0.223847106136 gnomAD-2.1.1 4.01E-06 None None None -0.267(OBSL1) -0.077(OBSCN) N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
G/S 35966 Ig-169 70 rs541322681 0.1169 -0.735 0.955 N 0.433 0.339 0.223847106136 gnomAD-3.1.2 1.31E-05 None None None -0.267(OBSL1) -0.077(OBSCN) N None 0 6.55E-05 0 0 0 None 0 0 0 2.07125E-04 0
G/S 35966 Ig-169 70 rs541322681 0.1169 -0.735 0.955 N 0.433 0.339 0.223847106136 1000 genomes 1.99681E-04 None None None -0.267(OBSL1) -0.077(OBSCN) N None 0 0 None None 0 0 None None None 1E-03 None
G/S 35966 Ig-169 70 rs541322681 0.1169 -0.735 0.955 N 0.433 0.339 0.223847106136 gnomAD-4.0.0 1.31335E-05 None None None -0.267(OBSL1) -0.077(OBSCN) N None 0 6.5368E-05 None 0 0 None 0 0 0 2.07297E-04 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.