Structural position:

  • Domain Type: Ig
  • Aligned Position: 153
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand F

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
R/Q 77 Ig-1 72 rs727503709 0.1135 0.097 0.991 N 0.665 0.263 0.232513804876 gnomAD-2.1.1 7.96E-06 None None None -0.385(TCAP) N None 0 0 None 0 0 None 0 None 0 1.76E-05 0
R/Q 77 Ig-1 72 rs727503709 0.1135 0.097 0.991 N 0.665 0.263 0.232513804876 gnomAD-4.0.0 4.10435E-06 None None None -0.385(TCAP) N None 2.98686E-05 0 None 0 0 None 0 0 2.69788E-06 2.31868E-05 0
R/Q 1012 Ig-3 70 rs368885310 0.4054 -0.274 0.997 N 0.674 0.296 None gnomAD-2.1.1 3.9E-05 None None None None N None 2.00385E-04 0 None 0 5.03E-05 None 9.8E-05 None 0 1.55E-05 0
R/Q 1012 Ig-3 70 rs368885310 0.4054 -0.274 0.997 N 0.674 0.296 None gnomAD-3.1.2 5.26E-05 None None None None N None 1.44893E-04 0 0 0 0 None 0 0 1.47E-05 2.07297E-04 0
R/Q 1012 Ig-3 70 rs368885310 0.4054 -0.274 0.997 N 0.674 0.296 None gnomAD-4.0.0 2.04468E-05 None None None None N None 2.13322E-04 0 None 0 8.91822E-05 None 0 0 5.08498E-06 6.58819E-05 1.60015E-05
I/L 1361 Ig-5 71 rs145308734 0.523 -0.663 0.817 N 0.309 0.194 None gnomAD-2.1.1 6.38E-05 None None None None N None 4.01E-05 0 None 0 0 None 0 None 0 1.3224E-04 0
I/L 1361 Ig-5 71 rs145308734 0.523 -0.663 0.817 N 0.309 0.194 None gnomAD-3.1.2 5.92E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 8.82E-05 0 0
I/L 1361 Ig-5 71 rs145308734 0.523 -0.663 0.817 N 0.309 0.194 None gnomAD-4.0.0 1.93325E-04 None None None None N None 4.00598E-05 0 None 0 0 None 0 0 2.45773E-04 1.09801E-05 2.88065E-04
I/V 1361 Ig-5 71 rs145308734 0.2315 -0.909 0.219 N 0.203 0.167 0.595645824669 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 5.45E-05 None 0 None 0 0 0
I/V 1361 Ig-5 71 rs145308734 0.2315 -0.909 0.219 N 0.203 0.167 0.595645824669 gnomAD-4.0.0 1.36824E-06 None None None None N None 0 0 None 0 2.5208E-05 None 0 0 8.99337E-07 0 0
E/G 1527 Ig-6 71 None 0.2978 None 1.0 D 0.76 0.7 0.718278560113 gnomAD-4.0.0 1.59098E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85695E-06 0 0
W/R 1627 Ig-7 72 None 0.9979 None 1.0 N 0.797 0.698 0.685966507736 gnomAD-4.0.0 1.59079E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
W/S 1627 Ig-7 72 None 0.969 None 1.0 N 0.794 0.55 0.837971455066 gnomAD-4.0.0 1.59083E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85664E-06 0 0
I/V 1774 Ig-8 72 rs758207512 0.0596 -0.437 None N 0.177 0.126 0.349870743963 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/N 2148 Ig-10 71 rs2092111633 0.7571 None 0.999 N 0.599 0.237 0.410469974859 gnomAD-4.0.0 1.59072E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85657E-06 0 0
D/Y 2243 Ig-11 70 rs138787974 0.1405 -0.172 1.0 N 0.791 0.644 None gnomAD-2.1.1 2.66611E-03 None None None None N None 2.7918E-02 1.10157E-03 None 0 0 None 3.27E-05 None 0 4.66E-05 1.3885E-03
D/Y 2243 Ig-11 70 rs138787974 0.1405 -0.172 1.0 N 0.791 0.644 None gnomAD-3.1.2 7.17225E-03 None None None None N None 2.52801E-02 1.83366E-03 0 0 0 None 0 0 4.41E-05 0 6.21415E-03
D/Y 2243 Ig-11 70 rs138787974 0.1405 -0.172 1.0 N 0.791 0.644 None 1000 genomes 8.38658E-03 None None None None N None 3.18E-02 0 None None 0 0 None None None 0 None
D/Y 2243 Ig-11 70 rs138787974 0.1405 -0.172 1.0 N 0.791 0.644 None gnomAD-4.0.0 1.39629E-03 None None None None N None 2.66821E-02 1.48348E-03 None 0 0 None 0 8.25627E-04 4.91609E-05 5.48992E-05 1.52068E-03
E/K 2335 Ig-12 69 rs756497839 0.0983 -0.625 0.014 N 0.193 0.258 0.238705975628 gnomAD-2.1.1 1.06E-05 None None None None N None 0 0 None 0 1.50602E-04 None 0 None 0 0 0
E/K 2335 Ig-12 69 rs756497839 0.0983 -0.625 0.014 N 0.193 0.258 0.238705975628 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 3.84468E-04 None 0 0 0 0 0
E/K 2335 Ig-12 69 rs756497839 0.0983 -0.625 0.014 N 0.193 0.258 0.238705975628 gnomAD-4.0.0 4.95636E-06 None None None None N None 0 0 None 0 1.78269E-04 None 0 0 0 0 0
N/D 2424 Ig-13 69 None 0.1089 None 0.014 N 0.359 0.144 0.0297737177859 gnomAD-4.0.0 1.36816E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79862E-06 0 0
N/S 2424 Ig-13 69 rs927165447 0.0704 -0.477 None N 0.117 0.052 0.0297737177859 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.85E-06 0
N/S 2424 Ig-13 69 rs927165447 0.0704 -0.477 None N 0.117 0.052 0.0297737177859 gnomAD-4.0.0 3.18114E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71327E-06 0 0
P/A 2514 Ig-14 70 rs375309644 0.0699 -1.217 0.011 N 0.274 0.291 0.208816687407 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92382E-04 None 0 0 0 0 0
P/A 2514 Ig-14 70 rs375309644 0.0699 -1.217 0.011 N 0.274 0.291 0.208816687407 gnomAD-4.0.0 6.57358E-06 None None None None N None 0 0 None 0 1.92382E-04 None 0 0 0 0 0
P/R 2514 Ig-14 70 None 0.0922 None None N 0.297 0.197 0.221019684889 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/T 2514 Ig-14 70 rs375309644 0.0791 -0.681 0.025 N 0.389 0.331 None gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
P/T 2514 Ig-14 70 rs375309644 0.0791 -0.681 0.025 N 0.389 0.331 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
P/T 2514 Ig-14 70 rs375309644 0.0791 -0.681 0.025 N 0.389 0.331 None gnomAD-4.0.0 2.56157E-06 None None None None N None 1.6921E-05 0 None 0 0 None 0 0 2.39188E-06 0 0
K/N 2601 Ig-15 69 rs988264686 0.1227 -0.622 0.007 N 0.321 0.072 0.184867976434 gnomAD-2.1.1 3.99E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/N 2601 Ig-15 69 rs988264686 0.1227 -0.622 0.007 N 0.321 0.072 0.184867976434 gnomAD-4.0.0 1.59113E-06 None None None None N None 0 2.28802E-05 None 0 0 None 0 0 0 0 0
E/Q 2688 Ig-16 68 rs748787636 0.1796 -0.059 0.928 N 0.609 0.312 0.282575091529 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.81E-06 0
E/Q 2688 Ig-16 68 rs748787636 0.1796 -0.059 0.928 N 0.609 0.312 0.282575091529 gnomAD-4.0.0 1.5906E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85657E-06 0 0
V/F 2776 Ig-17 70 rs752456093 0.4048 -0.685 1.0 D 0.806 0.488 0.870576066431 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 5.45E-05 None 0 None 0 0 0
V/F 2776 Ig-17 70 rs752456093 0.4048 -0.685 1.0 D 0.806 0.488 0.870576066431 gnomAD-4.0.0 1.59052E-06 None None None None I None 0 0 None 0 2.77423E-05 None 0 0 0 0 0
E/G 2950 Ig-19 69 None 0.3599 None 1.0 D 0.759 0.601 0.662942300025 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
E/A 3217 Ig-22 71 rs1014216424 0.4428 -0.824 0.996 D 0.617 0.589 0.558460104044 gnomAD-2.1.1 7.08E-06 None None None None N None 8.01E-05 0 None 0 0 None 0 None 0 0 0
E/A 3217 Ig-22 71 rs1014216424 0.4428 -0.824 0.996 D 0.617 0.589 0.558460104044 gnomAD-3.1.2 3.28E-05 None None None None N None 1.20616E-04 0 0 0 0 None 0 0 0 0 0
E/A 3217 Ig-22 71 rs1014216424 0.4428 -0.824 0.996 D 0.617 0.589 0.558460104044 gnomAD-4.0.0 4.95649E-06 None None None None N None 1.06761E-04 0 None 0 0 None 0 0 0 0 0
E/K 3217 Ig-22 71 rs759502450 0.3613 -0.019 0.767 D 0.319 0.366 0.397540356873 gnomAD-2.1.1 6.77E-05 None None None None N None 0 0 None 0 0 None 5.55301E-04 None 0 0 0
E/K 3217 Ig-22 71 rs759502450 0.3613 -0.019 0.767 D 0.319 0.366 0.397540356873 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 0 4.13907E-04 0
E/K 3217 Ig-22 71 rs759502450 0.3613 -0.019 0.767 D 0.319 0.366 0.397540356873 gnomAD-4.0.0 3.09788E-05 None None None None N None 0 0 None 0 0 None 0 0 0 5.3793E-04 1.60046E-05
T/P 3413 Ig-24 69 None 0.1122 None 0.266 D 0.505 0.253 0.328752806141 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
L/P 3729 Ig-26 70 None 0.2585 None None None None 0.08 None gnomAD-4.0.0 1.59119E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8582E-06 0 0
E/A 3889 Ig-27 70 None 0.2243 None 0.645 N 0.589 0.313 None gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
E/D 3889 Ig-27 70 rs377423256 0.2591 -0.874 0.006 N 0.391 0.091 None gnomAD-2.1.1 1.43E-05 None None None None I None 1.24018E-04 2.83E-05 None 0 0 None 0 None 0 0 0
E/D 3889 Ig-27 70 rs377423256 0.2591 -0.874 0.006 N 0.391 0.091 None gnomAD-3.1.2 5.92E-05 None None None None I None 1.93218E-04 0 0 0 0 None 0 0 0 0 4.77555E-04
E/D 3889 Ig-27 70 rs377423256 0.2591 -0.874 0.006 N 0.391 0.091 None gnomAD-4.0.0 1.05351E-05 None None None None I None 1.86986E-04 1.66767E-05 None 0 0 None 0 0 0 0 3.20195E-05
L/H 4008 Ig-28 71 None 0.1546 None 0.003 D 0.418 0.268 None gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
E/D 4674 Ig-29 69 rs761849101 0.1036 -0.797 0.001 D 0.313 0.181 None gnomAD-2.1.1 4.66E-06 None None None None N None 0 0 None 0 5.77E-05 None 0 None 0 0 0
E/D 4674 Ig-29 69 rs761849101 0.1036 -0.797 0.001 D 0.313 0.181 None gnomAD-4.0.0 7.09787E-07 None None None None N None 3.09809E-05 0 None 0 0 None 0 0 0 0 0
E/Q 4674 Ig-29 69 rs1196320491 0.1117 -0.553 0.002 D 0.325 0.144 None gnomAD-2.1.1 4.59E-06 None None None None N None 0 0 None 0 0 None 0 None 5.21E-05 0 0
E/Q 4674 Ig-29 69 rs1196320491 0.1117 -0.553 0.002 D 0.325 0.144 None gnomAD-4.0.0 1.72318E-06 None None None None N None 0 0 None 0 0 None 1.95351E-05 0 0 0 0
E/G 4769 Ig-30 70 None 0.3829 None 1.0 D 0.749 0.587 0.552451585512 gnomAD-4.0.0 1.59132E-06 None None None None I None 0 0 None 0 2.77454E-05 None 0 0 0 0 0
E/K 4769 Ig-30 70 rs566108422 0.2462 0.602 1.0 N 0.639 0.315 None gnomAD-2.1.1 4.02E-05 None None None None I None 2.58365E-04 5.8E-05 None 0 0 None 3.27E-05 None 0 1.78E-05 1.65782E-04
E/K 4769 Ig-30 70 rs566108422 0.2462 0.602 1.0 N 0.639 0.315 None gnomAD-3.1.2 3.29E-05 None None None None I None 1.20633E-04 0 0 0 0 None 0 0 0 0 0
E/K 4769 Ig-30 70 rs566108422 0.2462 0.602 1.0 N 0.639 0.315 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
E/K 4769 Ig-30 70 rs566108422 0.2462 0.602 1.0 N 0.639 0.315 None gnomAD-4.0.0 1.4252E-05 None None None None I None 1.0661E-04 4.99833E-05 None 0 2.22955E-05 None 0 0 7.62857E-06 1.09796E-05 1.60061E-05
E/V 4769 Ig-30 70 rs763092484 0.2672 -0.007 1.0 N 0.779 0.498 0.558850992237 gnomAD-2.1.1 1.21E-05 None None None None I None 1.93748E-04 0 None 0 0 None 0 None 0 0 0
E/V 4769 Ig-30 70 rs763092484 0.2672 -0.007 1.0 N 0.779 0.498 0.558850992237 gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
E/V 4769 Ig-30 70 rs763092484 0.2672 -0.007 1.0 N 0.779 0.498 0.558850992237 gnomAD-4.0.0 7.68647E-06 None None None None I None 1.01464E-04 0 None 0 0 None 0 0 0 0 0
T/A 4957 Ig-32 70 rs780405420 0.0716 -0.889 0.081 N 0.429 0.193 0.302459207581 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.63E-05 None 0 None 0 0 0
T/A 4957 Ig-32 70 rs780405420 0.0716 -0.889 0.081 N 0.429 0.193 0.302459207581 gnomAD-4.0.0 1.36918E-06 None None None None N None 0 0 None 0 2.52653E-05 None 0 0 8.9962E-07 0 0
T/I 4957 Ig-32 70 rs72648925 0.0818 -0.135 0.602 N 0.612 0.162 0.429552544315 gnomAD-2.1.1 1.21E-05 None None None None N None 1.295E-04 0 None 0 0 None 0 None 0 8.92E-06 0
T/I 4957 Ig-32 70 rs72648925 0.0818 -0.135 0.602 N 0.612 0.162 0.429552544315 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 4957 Ig-32 70 rs72648925 0.0818 -0.135 0.602 N 0.612 0.162 0.429552544315 gnomAD-4.0.0 2.7901E-05 None None None None N None 2.67258E-05 1.67051E-05 None 0 0 None 0 0 3.56055E-05 0 0
T/P 4957 Ig-32 70 None 0.1162 -0.488 0.301 D 0.577 0.332 None gnomAD-2.1.1 1.07562E-04 None None None None N None 4.14E-05 1.42183E-04 None 2.9098E-04 0 None 0 None 0 1.64644E-04 0
T/P 4957 Ig-32 70 None 0.1162 -0.488 0.301 D 0.577 0.332 None gnomAD-3.1.2 1.37994E-04 None None None None N None 0 1.96567E-04 0 2.88018E-04 0 None 0 0 2.49919E-04 0 0
T/P 4957 Ig-32 70 None 0.1162 -0.488 0.301 D 0.577 0.332 None gnomAD-4.0.0 9.36197E-05 None None None None N None 1.33626E-05 2.17152E-04 None 1.35263E-04 0 None 0 0 1.09359E-04 0 6.41108E-05
T/S 4957 Ig-32 70 rs72648925 0.0819 -0.552 0.042 N 0.414 0.12 0.268211541103 gnomAD-2.1.1 2.83993E-03 None None None None N None 2.89783E-04 5.17663E-03 None 1.02733E-02 0 None 1.1495E-03 None 3.21958E-04 3.30072E-03 4.65576E-03
T/S 4957 Ig-32 70 rs72648925 0.0819 -0.552 0.042 N 0.414 0.12 0.268211541103 gnomAD-3.1.2 2.87183E-03 None None None None N None 6.99604E-04 4.84483E-03 7.23684E-02 9.2219E-03 0 None 2.82646E-04 1.89873E-02 3.07272E-03 1.24275E-03 5.73614E-03
T/S 4957 Ig-32 70 rs72648925 0.0819 -0.552 0.042 N 0.414 0.12 0.268211541103 1000 genomes 1.79712E-03 None None None None N None 0 4.3E-03 None None 0 5E-03 None None None 1E-03 None
T/S 4957 Ig-32 70 rs72648925 0.0819 -0.552 0.042 N 0.414 0.12 0.268211541103 gnomAD-4.0.0 2.98458E-03 None None None None N None 6.67058E-04 5.21025E-03 None 9.53605E-03 0 None 3.44148E-04 2.09779E-02 2.98835E-03 1.02297E-03 5.39995E-03
S/C 5051 Ig-33 71 rs2081151606 0.1008 None 0.612 N 0.522 0.221 0.449860987313 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
E/K 5144 Ig-34 70 rs766612317 0.1009 -0.207 0.117 D 0.503 0.18 0.295623431141 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
E/K 5144 Ig-34 70 rs766612317 0.1009 -0.207 0.117 D 0.503 0.18 0.295623431141 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
E/K 5144 Ig-34 70 rs766612317 0.1009 -0.207 0.117 D 0.503 0.18 0.295623431141 gnomAD-4.0.0 5.88951E-05 None None None None N None 1.3349E-05 0 None 0 0 None 0 0 7.97028E-05 0 0
K/I 5237 Ig-35 70 rs2080944134 0.2498 None 1.0 D 0.762 0.49 0.572964795716 gnomAD-4.0.0 6.84216E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99481E-07 0 0
K/T 5237 Ig-35 70 None 0.1457 None 0.999 N 0.757 0.439 0.397691132334 gnomAD-4.0.0 6.84216E-07 None None None None I None 2.98775E-05 0 None 0 0 None 0 0 0 0 0
N/I 5426 Ig-37 70 rs761498812 0.1013 -0.104 None N 0.353 0.257 0.426787303895 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
N/I 5426 Ig-37 70 rs761498812 0.1013 -0.104 None N 0.353 0.257 0.426787303895 gnomAD-4.0.0 1.59237E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85935E-06 0 0
N/S 5426 Ig-37 70 rs761498812 0.0814 -0.107 None N 0.123 0.094 0.115124310173 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/S 5426 Ig-37 70 rs761498812 0.0814 -0.107 None N 0.123 0.094 0.115124310173 gnomAD-4.0.0 1.59237E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43369E-05 0
T/K 5519 Ig-38 70 None 0.1062 None 0.001 N 0.217 0.229 0.341460817117 gnomAD-4.0.0 6.84267E-07 None None None None N None 0 0 None 0 0 None 0 1.73671E-04 0 0 0
T/M 5519 Ig-38 70 rs1048810880 0.0759 0.13 0.895 N 0.475 0.157 0.660169151521 gnomAD-2.1.1 1.21E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 1.78E-05 0
T/M 5519 Ig-38 70 rs1048810880 0.0759 0.13 0.895 N 0.475 0.157 0.660169151521 gnomAD-3.1.2 1.31E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
T/M 5519 Ig-38 70 rs1048810880 0.0759 0.13 0.895 N 0.475 0.157 0.660169151521 gnomAD-4.0.0 1.42544E-05 None None None None N None 0 3.335E-05 None 0 0 None 0 1.64636E-04 1.35625E-05 1.09808E-05 4.80354E-05
T/S 5519 Ig-38 70 rs756756873 0.0824 -0.948 0.042 N 0.386 0.067 0.17948927462 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
T/S 5519 Ig-38 70 rs756756873 0.0824 -0.948 0.042 N 0.386 0.067 0.17948927462 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/S 5519 Ig-38 70 rs756756873 0.0824 -0.948 0.042 N 0.386 0.067 0.17948927462 gnomAD-4.0.0 3.09862E-05 None None None None N None 0 0 None 0 0 None 0 0 3.72957E-05 0 9.60646E-05
E/D 5613 Ig-39 71 rs397517483 0.1578 None 0.011 N 0.217 0.068 0.132336055621 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/D 5613 Ig-39 71 rs397517483 0.1578 None 0.011 N 0.217 0.068 0.132336055621 gnomAD-4.0.0 2.47881E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54289E-06 0 1.60108E-05
E/Q 5613 Ig-39 71 rs2080652790 0.1751 None 0.98 N 0.583 0.267 0.319114376414 gnomAD-4.0.0 1.59143E-06 None None None None N None 0 0 None 0 2.773E-05 None 0 0 0 0 0
E/A 5706 Ig-40 70 None 0.1695 None 0.012 N 0.392 0.18 0.298403945805 gnomAD-4.0.0 6.84234E-07 None None None None I None 2.98811E-05 0 None 0 0 None 0 0 0 0 0
E/G 5706 Ig-40 70 rs1176874608 0.2346 -1.534 0.055 N 0.536 0.255 0.353336612579 gnomAD-4.0.0 6.84234E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15947E-05 0
E/K 5706 Ig-40 70 rs376593556 0.1519 -0.018 None N 0.189 0.128 None gnomAD-2.1.1 4.65E-05 None None None None I None 4.96278E-04 2.83E-05 None 0 0 None 0 None 0 0 0
E/K 5706 Ig-40 70 rs376593556 0.1519 -0.018 None N 0.189 0.128 None gnomAD-3.1.2 1.77459E-04 None None None None I None 5.79151E-04 0 0 0 0 None 0 0 4.41E-05 0 0
E/K 5706 Ig-40 70 rs376593556 0.1519 -0.018 None N 0.189 0.128 None gnomAD-4.0.0 4.02818E-05 None None None None I None 6.00737E-04 1.66711E-05 None 0 0 None 0 0 1.01715E-05 3.29431E-05 6.40512E-05
E/Q 5706 Ig-40 70 rs376593556 0.1474 None 0.006 N 0.271 0.128 0.149567049428 gnomAD-4.0.0 6.84237E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15958E-05 0
K/R 5799 Ig-41 70 rs572678771 0.0918 -0.156 0.996 N 0.561 0.35 0.0884992946249 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.56E-05 None 0 None 0 0 0
K/R 5799 Ig-41 70 rs572678771 0.0918 -0.156 0.996 N 0.561 0.35 0.0884992946249 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92976E-04 None 0 0 0 0 0
K/R 5799 Ig-41 70 rs572678771 0.0918 -0.156 0.996 N 0.561 0.35 0.0884992946249 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
K/R 5799 Ig-41 70 rs572678771 0.0918 -0.156 0.996 N 0.561 0.35 0.0884992946249 gnomAD-4.0.0 2.47859E-06 None None None None N None 0 0 None 0 8.91583E-05 None 0 0 0 0 0
K/T 5799 Ig-41 70 None 0.3136 None 0.999 N 0.759 0.561 0.427829143865 gnomAD-4.0.0 6.84205E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
T/I 5988 Ig-43 70 rs749765281 0.087 0.125 0.627 N 0.556 0.167 0.438278051908 gnomAD-2.1.1 2.01E-05 None None None None N None 0 8.69E-05 None 0 0 None 0 None 0 8.88E-06 1.65673E-04
T/I 5988 Ig-43 70 rs749765281 0.087 0.125 0.627 N 0.556 0.167 0.438278051908 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.30993E-04 0 0 0 None 0 0 0 0 0
T/I 5988 Ig-43 70 rs749765281 0.087 0.125 0.627 N 0.556 0.167 0.438278051908 gnomAD-4.0.0 1.40954E-05 None None None None N None 0 1.35607E-04 None 0 0 None 0 0 2.3938E-06 1.34037E-05 2.84527E-05
T/A 6081 Ig-44 70 None 0.0743 None 0.08 D 0.254 0.241 0.18995819373 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 3.66327E-05
E/V 6268 Ig-46 70 rs1378963436 0.1672 -0.334 0.015 N 0.423 0.355 0.505765104075 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 9.98E-05 0 None 0 None 0 0 0
E/V 6268 Ig-46 70 rs1378963436 0.1672 -0.334 0.015 N 0.423 0.355 0.505765104075 gnomAD-4.0.0 1.59178E-06 None None None None N None 0 0 None 4.77145E-05 0 None 0 0 0 0 0
R/S 6361 Ig-47 70 None 0.6849 None 0.92 N 0.495 0.34 0.273503213844 gnomAD-4.0.0 1.59354E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43542E-05 0
Q/L 6454 Ig-48 70 None 0.104 None 0.012 N 0.363 0.219 0.275215494804 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
N/D 6550 Ig-49 70 rs1333479032 0.1741 None 0.003 N 0.179 0.08 0.17258766438 gnomAD-4.0.0 4.11047E-06 None None None None N None 0 0 None 0 0 None 0 0 5.4014E-06 0 0
Q/E 6643 Ig-50 70 None 0.0728 None None N 0.113 0.184 0.165133752707 gnomAD-4.0.0 1.59555E-06 None None None None N None 0 2.29589E-05 None 0 0 None 0 0 0 0 0
Q/H 6643 Ig-50 70 None 0.1117 None None N 0.117 0.191 0.0401082797425 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/R 6643 Ig-50 70 rs1399714010 0.079 0.203 None N 0.122 0.134 0.137902524267 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
Q/R 6643 Ig-50 70 rs1399714010 0.079 0.203 None N 0.122 0.134 0.137902524267 gnomAD-4.0.0 4.1136E-06 None None None None N None 0 0 None 0 0 None 0 0 5.40256E-06 0 0
D/A 6737 Ig-51 71 rs1280168103 0.4167 -0.644 0.901 N 0.593 0.317 0.425970041486 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 3.31E-05 None 0 0 0
D/A 6737 Ig-51 71 rs1280168103 0.4167 -0.644 0.901 N 0.593 0.317 0.425970041486 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 0 4.14079E-04 0
D/A 6737 Ig-51 71 rs1280168103 0.4167 -0.644 0.901 N 0.593 0.317 0.425970041486 gnomAD-4.0.0 2.48988E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.46718E-05 0
D/V 6737 Ig-51 71 None 0.3207 None 0.071 N 0.443 0.348 0.49741755877 gnomAD-4.0.0 1.37525E-06 None None None None N None 0 0 None 0 5.06355E-05 None 0 0 0 0 0
E/K 6830 Ig-52 70 rs1458416906 0.185 -0.261 0.877 D 0.554 0.303 0.31291088546 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
E/K 6830 Ig-52 70 rs1458416906 0.185 -0.261 0.877 D 0.554 0.303 0.31291088546 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 6830 Ig-52 70 rs1458416906 0.185 -0.261 0.877 D 0.554 0.303 0.31291088546 gnomAD-4.0.0 6.57272E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4702E-05 0 0
K/N 6924 Ig-53 71 rs369993514 0.5305 None 0.999 D 0.697 0.33 0.17258766438 gnomAD-4.0.0 6.8523E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00335E-07 0 0
K/T 6924 Ig-53 71 None 0.2999 None 0.999 N 0.745 0.49 0.52463718601 gnomAD-4.0.0 5.48061E-06 None None None None N None 0 0 None 0 0 None 0 0 7.20134E-06 0 0
T/A 7017 Ig-54 70 rs1483904842 0.0726 -0.911 0.625 N 0.462 0.149 0.208816687407 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/A 7017 Ig-54 70 rs1483904842 0.0726 -0.911 0.625 N 0.462 0.149 0.208816687407 gnomAD-4.0.0 1.59184E-06 None None None None N None 0 2.28822E-05 None 0 0 None 0 0 0 0 0
T/I 7017 Ig-54 70 rs893338987 0.0916 -0.091 0.669 N 0.519 0.221 0.447410926215 gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.56E-05 1.40568E-04
T/I 7017 Ig-54 70 rs893338987 0.0916 -0.091 0.669 N 0.519 0.221 0.447410926215 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
T/I 7017 Ig-54 70 rs893338987 0.0916 -0.091 0.669 N 0.519 0.221 0.447410926215 gnomAD-4.0.0 6.8176E-06 None None None None N None 0 0 None 0 0 None 0 0 5.93398E-06 2.19602E-05 3.20287E-05
N/D 7113 Ig-55 70 rs1309672541 0.0799 -1.254 0.012 N 0.348 0.119 0.0297737177859 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
N/D 7113 Ig-55 70 rs1309672541 0.0799 -1.254 0.012 N 0.348 0.119 0.0297737177859 gnomAD-4.0.0 3.18407E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86E-06 0 3.0259E-05
Q/P 7299 Ig-57 70 None 0.1413 None 0.065 N 0.459 0.3 0.268211541103 gnomAD-4.0.0 6.84291E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99546E-07 0 0
Q/R 7299 Ig-57 70 None 0.0769 None None N 0.117 0.059 0.167679373172 gnomAD-4.0.0 1.36858E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.319E-05 0
E/D 7392 Ig-58 70 rs2078620935 0.1192 None 0.988 N 0.488 0.265 0.231873229951 gnomAD-4.0.0 2.05348E-06 None None None None N None 8.97076E-05 0 None 0 0 None 0 0 0 0 0
Q/L 7488 Ig-59 70 rs959952502 0.125 None 0.647 N 0.449 0.303 None gnomAD-4.0.0 6.16171E-06 None None None None N None 0 0 None 3.45092E-04 0 None 0 0 0 0 0
Q/L 7584 Ig-60 70 rs530109283 0.0784 0.661 None N 0.259 0.251 0.430579932962 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
Q/L 7584 Ig-60 70 rs530109283 0.0784 0.661 None N 0.259 0.251 0.430579932962 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
Q/L 7584 Ig-60 70 rs530109283 0.0784 0.661 None N 0.259 0.251 0.430579932962 gnomAD-4.0.0 6.5653E-06 None None None None N None 0 6.53937E-05 None 0 0 None 0 0 0 0 0
Q/R 7584 Ig-60 70 rs530109283 0.0956 None None N 0.147 0.148 0.139678290688 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
Q/R 7584 Ig-60 70 rs530109283 0.0956 None None N 0.147 0.148 0.139678290688 gnomAD-4.0.0 2.02982E-06 None None None None N None 0 6.15157E-05 None 0 0 None 0 0 1.20493E-06 0 0
E/K 7771 Ig-62 70 None 0.2034 None 0.984 N 0.587 0.315 0.370240404367 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 3.9375E-06 0 0
K/R 7865 Ig-63 71 rs746952741 0.0916 -0.185 0.226 N 0.351 0.172 0.343560092441 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
K/R 7865 Ig-63 71 rs746952741 0.0916 -0.185 0.226 N 0.351 0.172 0.343560092441 gnomAD-4.0.0 2.7373E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59827E-06 0 0
I/K 8054 Ig-65 70 rs745362139 0.0905 -0.665 0.001 N 0.378 0.086 0.269558022972 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 1.11321E-04 None 0 None 0 0 0
I/K 8054 Ig-65 70 rs745362139 0.0905 -0.665 0.001 N 0.378 0.086 0.269558022972 gnomAD-4.0.0 2.22778E-05 None None None None N None 0 0 None 0 3.88199E-04 None 0 0 0 0 0
I/L 8054 Ig-65 70 rs72648976 0.0744 -0.619 0.001 N 0.174 0.078 0.201204373187 gnomAD-2.1.1 2.15513E-03 None None None None N None 2.35299E-02 7.07014E-04 None 0 0 None 0 None 0 3.13E-05 7.02445E-04
I/L 8054 Ig-65 70 rs72648976 0.0744 -0.619 0.001 N 0.174 0.078 0.201204373187 gnomAD-3.1.2 6.42981E-03 None None None None N None 2.2792E-02 1.50662E-03 0 0 0 None 0 0 7.35E-05 0 2.87081E-03
I/L 8054 Ig-65 70 rs72648976 0.0744 -0.619 0.001 N 0.174 0.078 0.201204373187 1000 genomes 5.99042E-03 None None None None N None 2.19E-02 1.4E-03 None None 0 0 None None None 0 None
I/L 8054 Ig-65 70 rs72648976 0.0744 -0.619 0.001 N 0.174 0.078 0.201204373187 gnomAD-4.0.0 1.14453E-03 None None None None N None 2.26121E-02 9.66538E-04 None 0 0 None 0 1.65125E-04 2.03434E-05 0 1.08838E-03
I/V 8054 Ig-65 70 None 0.0672 None None N 0.118 0.09 0.295623431141 gnomAD-4.0.0 6.84212E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99481E-07 0 0
D/A 8147 Ig-66 70 None 0.1812 None 0.09 N 0.485 0.245 0.361360026772 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/E 8147 Ig-66 70 None 0.142 None 0.001 N 0.174 0.119 0.141422826196 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/Y 8147 Ig-66 70 None 0.1894 None 0.912 N 0.621 0.363 0.653592515387 gnomAD-4.0.0 1.59131E-06 None None None None N None 0 0 None 0 2.773E-05 None 0 0 0 0 0
Q/H 8240 Ig-67 70 rs1350676942 0.1493 None 0.882 N 0.419 0.322 0.185906805712 gnomAD-4.0.0 6.84224E-07 None None None None I None 0 0 None 0 0 None 0 1.73551E-04 0 0 0
Q/R 8240 Ig-67 70 rs747625896 0.0754 -0.211 None N 0.107 0.183 0.187945064343 gnomAD-2.1.1 2.01E-05 None None None None I None 0 1.44877E-04 None 0 0 None 0 None 0 0 0
Q/R 8240 Ig-67 70 rs747625896 0.0754 -0.211 None N 0.107 0.183 0.187945064343 gnomAD-4.0.0 1.27308E-05 None None None None I None 0 1.82907E-04 None 0 0 None 0 0 0 0 0
E/D 8333 Ig-68 70 rs1438182051 0.1884 -0.651 0.797 N 0.519 0.316 0.233785782151 gnomAD-2.1.1 3.18E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
E/D 8333 Ig-68 70 rs1438182051 0.1884 -0.651 0.797 N 0.519 0.316 0.233785782151 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/D 8333 Ig-68 70 rs1438182051 0.1884 -0.651 0.797 N 0.519 0.316 0.233785782151 gnomAD-4.0.0 2.56224E-06 None None None None I None 0 0 None 0 0 None 0 0 4.78675E-06 0 0
E/G 8333 Ig-68 70 rs770811407 0.241 -1.337 0.99 N 0.627 0.515 0.556183318313 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
E/G 8333 Ig-68 70 rs770811407 0.241 -1.337 0.99 N 0.627 0.515 0.556183318313 gnomAD-4.0.0 7.95689E-06 None None None None I None 0 0 None 0 0 None 3.76464E-05 0 2.85873E-06 0 6.04778E-05
Q/R 8429 Ig-69 70 rs757938943 0.1328 0.102 0.112 N 0.32 0.182 0.163833314356 gnomAD-2.1.1 8.08E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 8.93E-06 0
Q/R 8429 Ig-69 70 rs757938943 0.1328 0.102 0.112 N 0.32 0.182 0.163833314356 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
Q/R 8429 Ig-69 70 rs757938943 0.1328 0.102 0.112 N 0.32 0.182 0.163833314356 gnomAD-4.0.0 9.91837E-06 None None None None N None 0 1.66806E-05 None 0 0 None 0 0 1.27167E-05 0 0
Q/L 8525 Ig-70 70 None 0.0832 None None N 0.239 0.301 0.270447802918 gnomAD-4.0.0 2.05295E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69876E-06 0 0
Q/P 8525 Ig-70 70 rs2077609752 0.1826 None 0.224 N 0.461 0.29 0.233785782151 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
Q/P 8525 Ig-70 70 rs2077609752 0.1826 None 0.224 N 0.461 0.29 0.233785782151 gnomAD-4.0.0 6.57013E-06 None None None None N None 2.41103E-05 0 None 0 0 None 0 0 0 0 0
D/G 8619 Ig-71 71 rs2077359221 0.3554 None 0.95 N 0.512 0.361 0.341696514166 gnomAD-4.0.0 4.10566E-06 None None None None N None 0 0 None 0 0 None 0 3.47102E-04 3.59823E-06 0 0
E/K 8712 Ig-72 70 None 0.1036 None 0.534 N 0.57 0.218 0.271763555656 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
V/I 8899 Ig-74 70 rs765131331 0.0652 None None N 0.169 0.062 0.256283259241 gnomAD-4.0.0 2.73712E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59814E-06 0 0
V/L 8899 Ig-74 70 rs765131331 0.089 -0.437 None N 0.151 0.06 0.1749357433 gnomAD-2.1.1 8.04E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 1.65782E-04
V/L 8899 Ig-74 70 rs765131331 0.089 -0.437 None N 0.151 0.06 0.1749357433 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/L 8899 Ig-74 70 rs765131331 0.089 -0.437 None N 0.151 0.06 0.1749357433 gnomAD-4.0.0 5.57778E-06 None None None None N None 0 1.66756E-05 None 0 0 None 0 0 6.78135E-06 0 0
D/E 8995 Ig-75 70 rs781351100 0.1013 -0.351 None N 0.117 0.105 0.0986583533028 gnomAD-2.1.1 8.04E-05 None None None None N None 0 0 None 0 0 None 6.53979E-04 None 0 0 0
D/E 8995 Ig-75 70 rs781351100 0.1013 -0.351 None N 0.117 0.105 0.0986583533028 gnomAD-3.1.2 3.94E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 6.21118E-04 0
D/E 8995 Ig-75 70 rs781351100 0.1013 -0.351 None N 0.117 0.105 0.0986583533028 gnomAD-4.0.0 6.19715E-05 None None None None N None 0 0 None 0 0 None 0 6.57678E-04 1.61047E-05 8.12526E-04 4.80307E-05
D/G 8995 Ig-75 70 rs747976104 0.0989 -0.717 None N 0.189 0.101 0.136095386433 gnomAD-2.1.1 1.61E-05 None None None None N None 0 1.16043E-04 None 0 0 None 0 None 0 0 0
D/G 8995 Ig-75 70 rs747976104 0.0989 -0.717 None N 0.189 0.101 0.136095386433 gnomAD-4.0.0 6.36551E-06 None None None None N None 0 9.14788E-05 None 0 0 None 0 0 0 0 0
Q/P 9181 Ig-77 70 rs758826201 0.1703 -0.048 0.006 N 0.231 0.351 0.32580497728 gnomAD-2.1.1 8.03E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
Q/P 9181 Ig-77 70 rs758826201 0.1703 -0.048 0.006 N 0.231 0.351 0.32580497728 gnomAD-4.0.0 3.18237E-06 None None None None N None 0 4.57268E-05 None 0 0 None 0 0 0 0 0
Q/K 9466 Ig-80 70 None 0.0893 None None None 0.151 0.229 0.126345400529 gnomAD-4.0.0 1.36865E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99442E-07 0 1.65711E-05
Q/P 9466 Ig-80 70 rs1215467586 0.1692 -0.066 0.523 None 0.505 0.359 0.375326005269 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
Q/P 9466 Ig-80 70 rs1215467586 0.1692 -0.066 0.523 None 0.505 0.359 0.375326005269 gnomAD-4.0.0 1.36865E-06 None None None None N None 5.97693E-05 0 None 0 0 None 0 0 0 0 0
L/S 9563 Ig-81 71 None 0.6551 None 0.852 None 0.535 0.168 0.767653027609 gnomAD-4.0.0 6.84185E-07 None None None None I None 0 0 None 0 2.51927E-05 None 0 0 0 0 0
L/W 9563 Ig-81 71 rs770692880 0.565 -0.894 0.999 None 0.619 0.383 0.832404605066 gnomAD-2.1.1 3.21E-05 None None None None I None 0 0 None 0 4.60971E-04 None 0 None 0 0 0
L/W 9563 Ig-81 71 rs770692880 0.565 -0.894 0.999 None 0.619 0.383 0.832404605066 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 3.84468E-04 None 0 0 0 0 0
L/W 9563 Ig-81 71 rs770692880 0.565 -0.894 0.999 None 0.619 0.383 0.832404605066 gnomAD-4.0.0 3.71786E-06 None None None None I None 0 0 None 0 1.33642E-04 None 0 0 0 0 0
D/V 9659 Ig-82 70 None 0.3116 None 0.994 None 0.845 0.392 0.635563547672 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 3.66327E-05
L/F 9768 Ig-83 71 None 0.2806 None 0.927 None 0.478 0.289 0.151104730317 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/S 9970 Ig-84 71 rs2075551861 0.2106 None 0.984 None 0.543 0.209 0.352476196916 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
N/S 9970 Ig-84 71 rs2075551861 0.2106 None 0.984 None 0.543 0.209 0.352476196916 gnomAD-4.0.0 2.5628E-06 None None None None N None 0 0 None 0 0 None 0 2.24014E-04 0 1.34228E-05 0
Q/P 10057 Ig-85 69 None 0.2236 None 0.106 None 0.523 0.23 0.202086224978 gnomAD-4.0.0 4.10489E-06 None None None None N None 0 0 None 0 0 None 0 0 5.3964E-06 0 0
Q/R 10057 Ig-85 69 rs2075483683 0.0771 None None None 0.16 0.102 0.0611884634855 gnomAD-4.0.0 6.84148E-07 None None None None N None 0 0 None 0 0 None 0 0 8.994E-07 0 0
V/D 10146 Ig-86 69 rs372185371 0.8753 -0.098 1.0 None 0.789 0.489 0.851908029137 gnomAD-2.1.1 1.43E-05 None None None None N None 1.23998E-04 2.83E-05 None 0 0 None 0 None 0 0 0
V/D 10146 Ig-86 69 rs372185371 0.8753 -0.098 1.0 None 0.789 0.489 0.851908029137 gnomAD-3.1.2 6.57E-05 None None None None N None 2.41383E-04 0 0 0 0 None 0 0 0 0 0
V/D 10146 Ig-86 69 rs372185371 0.8753 -0.098 1.0 None 0.789 0.489 0.851908029137 gnomAD-4.0.0 9.91425E-06 None None None None N None 1.86896E-04 3.33356E-05 None 0 0 None 0 0 0 0 0
V/G 10146 Ig-86 69 rs372185371 0.8262 None 1.0 None 0.775 0.567 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/G 10146 Ig-86 69 rs372185371 0.8262 None 1.0 None 0.775 0.567 None gnomAD-4.0.0 6.57272E-06 None None None None N None 2.41383E-05 0 None 0 0 None 0 0 0 0 0
V/I 10146 Ig-86 69 rs1553875094 0.1022 None 0.997 None 0.536 0.238 0.640388181781 gnomAD-4.0.0 1.59088E-06 None None None None N None 0 0 None 0 0 None 0 2.4108E-04 0 0 0
E/A 13755 Ig-87 72 None 0.3198 None 0.999 D 0.703 0.595 0.47409059586 gnomAD-4.0.0 1.59234E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85992E-06 0 0
T/I 13849 Ig-88 70 rs759603723 0.1433 -0.063 0.27 N 0.421 0.068 0.176091768786 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/I 13849 Ig-88 70 rs759603723 0.1433 -0.063 0.27 N 0.421 0.068 0.176091768786 gnomAD-4.0.0 1.59286E-06 None None None None N None 0 2.28728E-05 None 0 0 None 0 0 0 0 0
E/V 13944 Ig-89 69 None 0.7063 None 0.999 N 0.778 0.521 0.423836183345 gnomAD-4.0.0 1.61311E-06 None None None None N None 0 2.34973E-05 None 0 0 None 0 0 0 0 0
E/D 14033 Ig-90 69 rs759297459 0.7649 -0.909 0.997 N 0.642 0.207 0.223847106136 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
E/D 14033 Ig-90 69 rs759297459 0.7649 -0.909 0.997 N 0.642 0.207 0.223847106136 gnomAD-4.0.0 6.84451E-07 None None None None N None 0 0 None 0 2.52169E-05 None 0 0 0 0 0
V/A 14121 Ig-91 68 None 0.1602 None 0.244 N 0.281 0.186 0.601974941769 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/F 14121 Ig-91 68 None 0.1504 None 0.006 N 0.249 0.244 0.776660857837 gnomAD-4.0.0 6.3716E-06 None None None None I None 0 0 None 0 0 None 0 0 8.58192E-06 1.43332E-05 0
V/G 14121 Ig-91 68 None 0.2279 None 0.425 D 0.406 0.319 0.827173928948 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 14298 Ig-93 68 rs778634417 0.1823 -0.389 0.198 D 0.499 0.238 None gnomAD-2.1.1 1.61E-05 None None None None N None 6.46E-05 0 None 0 1.12183E-04 None 0 None 0 8.88E-06 0
E/K 14298 Ig-93 68 rs778634417 0.1823 -0.389 0.198 D 0.499 0.238 None gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 1.93274E-04 None 0 0 1.47E-05 0 0
E/K 14298 Ig-93 68 rs778634417 0.1823 -0.389 0.198 D 0.499 0.238 None gnomAD-4.0.0 1.05379E-05 None None None None N None 2.67073E-05 0 None 0 6.70391E-05 None 0 0 9.32524E-06 0 1.60205E-05
E/A 14387 Ig-94 69 None 0.233 None 0.104 N 0.609 0.163 0.183819452728 gnomAD-4.0.0 1.59251E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86079E-06 0 0
E/Q 14387 Ig-94 69 None 0.2303 None 0.007 N 0.267 0.064 0.139678290688 gnomAD-4.0.0 6.84439E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99717E-07 0 0
E/V 14387 Ig-94 69 rs749959242 0.2873 0.009 0.449 N 0.665 0.239 0.30921473904 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
E/V 14387 Ig-94 69 rs749959242 0.2873 0.009 0.449 N 0.665 0.239 0.30921473904 gnomAD-4.0.0 4.77754E-06 None None None None N None 0 0 None 0 0 None 0 0 8.58236E-06 0 0
Q/P 14565 Ig-96 69 rs1357364341 0.2099 None 0.856 D 0.518 0.301 0.41337360676 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
Q/P 14565 Ig-96 69 rs1357364341 0.2099 None 0.856 D 0.518 0.301 0.41337360676 gnomAD-4.0.0 6.57644E-06 None None None None N None 0 6.55738E-05 None 0 0 None 0 0 0 0 0
Q/E 14654 Ig-97 69 None 0.0657 None None N 0.125 0.129 0.177238962908 gnomAD-4.0.0 6.84398E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.1595E-05 0
Q/K 14654 Ig-97 69 rs1463883512 0.0861 0.187 0.001 N 0.167 0.157 0.17258766438 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
Q/K 14654 Ig-97 69 rs1463883512 0.0861 0.187 0.001 N 0.167 0.157 0.17258766438 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
Q/K 14654 Ig-97 69 rs1463883512 0.0861 0.187 0.001 N 0.167 0.157 0.17258766438 gnomAD-4.0.0 6.5741E-06 None None None None N None 2.41266E-05 0 None 0 0 None 0 0 0 0 0
G/E 14743 Ig-98 69 rs753855392 0.216 -1.047 0.002 N 0.405 0.285 0.112648838833 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/G 14832 Ig-99 68 rs1354845947 0.2747 None 0.994 D 0.647 0.56 0.582764979894 gnomAD-4.0.0 1.61298E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.46374E-05 0
T/I 14921 Ig-100 69 rs776808932 0.1868 None 0.627 N 0.537 0.287 0.295974979623 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/I 14921 Ig-100 69 rs776808932 0.1868 None 0.627 N 0.537 0.287 0.295974979623 gnomAD-4.0.0 2.73851E-06 None None None None N None 2.99401E-05 0 None 0 0 None 0 0 8.99909E-07 2.31959E-05 0
E/K 15010 Ig-101 69 None 0.2647 None 0.999 D 0.665 0.398 0.394536629495 gnomAD-4.0.0 1.59483E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86397E-06 0 0
N/K 15099 Ig-102 69 rs746107267 0.1895 0.085 None N 0.13 0.116 0.148003135375 gnomAD-2.1.1 8.07E-06 None None None None N None 0 5.82E-05 None 0 0 None 0 None 0 0 0
N/K 15099 Ig-102 69 rs746107267 0.1895 0.085 None N 0.13 0.116 0.148003135375 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/K 15099 Ig-102 69 rs746107267 0.1895 0.085 None N 0.13 0.116 0.148003135375 gnomAD-4.0.0 2.73895E-06 None None None None N None 0 8.967E-05 None 0 0 None 0 0 0 0 0
N/S 15099 Ig-102 69 rs1239591907 0.0656 -0.795 None N 0.108 0.115 0.0482279557977 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
N/S 15099 Ig-102 69 rs1239591907 0.0656 -0.795 None N 0.108 0.115 0.0482279557977 gnomAD-3.1.2 1.32E-05 None None None None N None 0 1.31389E-04 0 0 0 None 0 0 0 0 0
N/S 15099 Ig-102 69 rs1239591907 0.0656 -0.795 None N 0.108 0.115 0.0482279557977 gnomAD-4.0.0 5.13279E-06 None None None None N None 0 6.79579E-05 None 0 0 None 0 0 0 0 0
N/H 15276 Ig-104 69 None 0.0885 None 0.912 N 0.561 0.182 0.366277470483 gnomAD-4.0.0 1.59329E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86261E-06 0 0
E/V 15370 Ig-105 69 None 0.3918 None 1.0 N 0.797 0.486 0.581503058331 gnomAD-4.0.0 1.59445E-06 None None None None N None 0 0 None 0 2.77994E-05 None 0 0 0 0 0
E/Q 15459 Ig-106 69 rs752596345 0.5743 -0.824 1.0 N 0.617 0.388 0.345405024496 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.98E-06 0
E/Q 15459 Ig-106 69 rs752596345 0.5743 -0.824 1.0 N 0.617 0.388 0.345405024496 gnomAD-4.0.0 1.59515E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86518E-06 0 0
E/A 15548 Ig-107 69 None 0.4412 None 0.999 D 0.689 0.521 0.465806656444 gnomAD-4.0.0 6.84835E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00118E-07 0 0
E/Q 15548 Ig-107 69 rs1364430603 0.4006 None 1.0 N 0.629 0.235 0.431150418975 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.57E-05 0 0 0 None 0 0 0 0 0
E/Q 15548 Ig-107 69 rs1364430603 0.4006 None 1.0 N 0.629 0.235 0.431150418975 gnomAD-4.0.0 6.58458E-06 None None None None N None 0 6.5703E-05 None 0 0 None 0 0 0 0 0
E/V 15548 Ig-107 69 rs1281939698 0.3382 0.056 1.0 N 0.805 0.523 0.469660041277 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
E/V 15548 Ig-107 69 rs1281939698 0.3382 0.056 1.0 N 0.805 0.523 0.469660041277 gnomAD-4.0.0 6.84835E-07 None None None None N None 0 2.24115E-05 None 0 0 None 0 0 0 0 0
R/K 15634 Ig-108 67 None 0.1209 None 0.78 N 0.606 0.107 0.329540904979 gnomAD-4.0.0 1.5944E-06 None None None None N None 0 0 None 4.77692E-05 0 None 0 0 0 0 0
R/S 15634 Ig-108 67 None 0.5306 None 0.103 N 0.343 0.145 0.0611884634855 gnomAD-4.0.0 6.84754E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99986E-07 0 0
I/T 16032 Ig-109 65 rs879171203 0.1769 -1.714 0.122 N 0.293 0.207 None gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
I/T 16032 Ig-109 65 rs879171203 0.1769 -1.714 0.122 N 0.293 0.207 None gnomAD-4.0.0 1.59322E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8621E-06 0 0
I/V 16032 Ig-109 65 rs794729443 0.093 -0.969 0.816 N 0.351 0.118 0.532216101619 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
I/V 16032 Ig-109 65 rs794729443 0.093 -0.969 0.816 N 0.351 0.118 0.532216101619 gnomAD-4.0.0 1.59324E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86211E-06 0 0
T/I 16328 Ig-110 67 rs770839243 0.287 -0.139 0.908 N 0.781 0.323 0.362361684037 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 9.82E-05 None 0 0 1.66611E-04
T/I 16328 Ig-110 67 rs770839243 0.287 -0.139 0.908 N 0.781 0.323 0.362361684037 gnomAD-4.0.0 6.16275E-06 None None None None N None 0 0 None 0 0 None 0 0 0 8.12423E-05 3.31675E-05
I/S 17024 Ig-111 70 rs1389981053 0.1421 -1.714 0.003 N 0.303 0.141 0.646007317467 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/S 17024 Ig-111 70 rs1389981053 0.1421 -1.714 0.003 N 0.303 0.141 0.646007317467 gnomAD-4.0.0 3.18653E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86722E-05 0
L/M 17346 Ig-112 96 None 0.0917 None 0.002 N 0.266 0.028 0.353125101423 gnomAD-4.0.0 1.67988E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.6039E-05 0
L/P 17346 Ig-112 96 rs755155531 0.2338 -1.225 0.295 D 0.547 0.225 0.627816896369 gnomAD-2.1.1 8.05E-06 None None None None N None 8.44E-05 0 None 0 0 None 0 None 0 0 0
L/P 17346 Ig-112 96 rs755155531 0.2338 -1.225 0.295 D 0.547 0.225 0.627816896369 gnomAD-3.1.2 1.97E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 0 0
L/P 17346 Ig-112 96 rs755155531 0.2338 -1.225 0.295 D 0.547 0.225 0.627816896369 gnomAD-4.0.0 6.72363E-06 None None None None N None 6.9173E-05 0 None 0 0 None 0 0 2.49159E-06 0 0
L/V 17346 Ig-112 96 None 0.069 None None N 0.251 0.041 0.418467456957 gnomAD-4.0.0 1.67988E-06 None None None None N None 0 0 None 0 0 None 0 0 2.98691E-06 0 0
R/G 17741 Ig-113 65 rs1189355872 0.6307 None 0.959 N 0.525 0.452 0.692629309879 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/G 17741 Ig-113 65 rs1189355872 0.6307 None 0.959 N 0.525 0.452 0.692629309879 gnomAD-4.0.0 6.578E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47167E-05 0 0
T/A 18042 Ig-114 75 rs1034402778 0.0963 None 0.911 N 0.389 0.128 0.270889551736 gnomAD-4.0.0 3.42447E-06 None None None None N None 0 0 None 0 0 None 0 0 3.60064E-06 0 1.65865E-05
K/I 18456 Ig-115 75 None 0.3727 None 0.896 N 0.581 0.392 0.591556180789 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/V 18761 Ig-116 74 None 0.1077 None 0.835 N 0.449 0.085 0.52122689477 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/F 19160 Ig-117 66 rs200778464 0.1697 -1.099 0.81 N 0.543 0.304 0.597869843003 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/F 19160 Ig-117 66 rs200778464 0.1697 -1.099 0.81 N 0.543 0.304 0.597869843003 gnomAD-4.0.0 6.84489E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15947E-05 0
V/I 19160 Ig-117 66 None 0.0653 -0.351 0.004 N 0.182 0.039 0.20549828249 gnomAD-2.1.1 9.28E-05 None None None None N None 0 3.19712E-04 None 0 0 None 0 None 0 8.92E-05 3.32779E-04
V/I 19160 Ig-117 66 None 0.0653 -0.351 0.004 N 0.182 0.039 0.20549828249 gnomAD-3.1.2 8.55E-05 None None None None N None 2.41E-05 5.24178E-04 0 0 0 None 0 0 4.41E-05 0 4.78469E-04
V/I 19160 Ig-117 66 None 0.0653 -0.351 0.004 N 0.182 0.039 0.20549828249 1000 genomes 5.99042E-04 None None None None N None 0 1.4E-03 None None 0 2E-03 None None None 0 None
V/I 19160 Ig-117 66 None 0.0653 -0.351 0.004 N 0.182 0.039 0.20549828249 gnomAD-4.0.0 5.39335E-05 None None None None N None 1.33358E-05 3.50385E-04 None 0 0 None 0 0 4.9174E-05 0 1.12104E-04
V/L 19160 Ig-117 66 rs200778464 0.1591 -0.39 0.002 N 0.181 0.111 None gnomAD-2.1.1 1.3965E-04 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 2.90137E-04 0
V/L 19160 Ig-117 66 rs200778464 0.1591 -0.39 0.002 N 0.181 0.111 None gnomAD-3.1.2 1.84167E-04 None None None None N None 2.41E-05 0 0 0 0 None 0 0 3.97176E-04 0 0
V/L 19160 Ig-117 66 rs200778464 0.1591 -0.39 0.002 N 0.181 0.111 None gnomAD-4.0.0 3.04406E-04 None None None None N None 5.34302E-05 0 None 0 0 None 0 0 4.07803E-04 0 9.6123E-05
K/R 19456 Ig-118 66 None 0.0797 None 0.002 N 0.173 0.091 0.232513804876 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/T 19854 Ig-119 65 rs1291718498 0.1862 -1.589 0.001 N 0.205 0.109 0.603063929177 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
Y/C 21536 Ig-124 68 rs551977619 0.0993 -0.07 1.0 N 0.697 0.379 0.672823973603 gnomAD-2.1.1 4.03E-06 None None None None I None 6.47E-05 0 None 0 0 None 0 None 0 0 0
Y/C 21536 Ig-124 68 rs551977619 0.0993 -0.07 1.0 N 0.697 0.379 0.672823973603 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
Y/C 21536 Ig-124 68 rs551977619 0.0993 -0.07 1.0 N 0.697 0.379 0.672823973603 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
Y/C 21536 Ig-124 68 rs551977619 0.0993 -0.07 1.0 N 0.697 0.379 0.672823973603 gnomAD-4.0.0 6.56797E-06 None None None None I None 2.40512E-05 0 None 0 0 None 0 0 0 0 0
Y/H 21536 Ig-124 68 rs1487784985 0.1382 0.487 0.999 N 0.749 0.213 0.519460762563 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
Y/H 21536 Ig-124 68 rs1487784985 0.1382 0.487 0.999 N 0.749 0.213 0.519460762563 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Y/H 21536 Ig-124 68 rs1487784985 0.1382 0.487 0.999 N 0.749 0.213 0.519460762563 gnomAD-4.0.0 2.47949E-06 None None None None I None 0 0 None 0 0 None 0 0 2.54347E-06 0 1.60174E-05
D/H 21933 Ig-125 68 rs1453626597 0.2378 -0.876 0.97 N 0.725 0.398 0.280181792013 gnomAD-4.0.0 1.62746E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.08128E-05
D/N 21933 Ig-125 68 rs1453626597 0.0769 -0.766 0.822 N 0.56 0.313 0.241078983079 gnomAD-2.1.1 4.1E-06 None None None None N None 0 2.98E-05 None 0 0 None 0 None 0 0 0
D/N 21933 Ig-125 68 rs1453626597 0.0769 -0.766 0.822 N 0.56 0.313 0.241078983079 gnomAD-4.0.0 1.62746E-06 None None None None N None 0 2.33776E-05 None 0 0 None 0 0 0 0 0
E/A 23017 Ig-128 68 rs1393720998 0.1959 -0.997 0.999 N 0.721 0.516 0.481988042695 gnomAD-2.1.1 1.79E-05 None None None None N None 0 0 None 0 2.58425E-04 None 0 None 0 0 0
E/A 23017 Ig-128 68 rs1393720998 0.1959 -0.997 0.999 N 0.721 0.516 0.481988042695 gnomAD-3.1.2 1.98E-05 None None None None N None 0 0 0 0 5.83204E-04 None 0 0 0 0 0
E/A 23017 Ig-128 68 rs1393720998 0.1959 -0.997 0.999 N 0.721 0.516 0.481988042695 gnomAD-4.0.0 5.57988E-06 None None None None N None 0 0 None 0 1.78979E-04 None 0 0 0 0 1.6019E-05
E/K 23017 Ig-128 68 rs1433111553 0.1919 -0.573 0.999 N 0.638 0.445 0.391470661076 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/K 23017 Ig-128 68 rs1433111553 0.1919 -0.573 0.999 N 0.638 0.445 0.391470661076 gnomAD-4.0.0 1.59233E-06 None None None None N None 0 2.28739E-05 None 0 0 None 0 0 0 0 0
P/H 23703 Ig-130 67 None 0.1115 None 0.873 N 0.499 0.228 0.413891365518 gnomAD-4.0.0 6.00165E-06 None None None None N None 0 0 None 0 0 None 0 0 6.56256E-06 0 0
A/S 24099 Ig-131 71 rs748236500 0.0917 -1.161 0.477 N 0.537 0.194 0.285698343383 gnomAD-2.1.1 2.82E-05 None None None None N None 0 1.74662E-04 None 0 0 None 0 None 0 8.9E-06 0
A/S 24099 Ig-131 71 rs748236500 0.0917 -1.161 0.477 N 0.537 0.194 0.285698343383 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
A/S 24099 Ig-131 71 rs748236500 0.0917 -1.161 0.477 N 0.537 0.194 0.285698343383 gnomAD-4.0.0 1.1562E-05 None None None None N None 0 1.35925E-04 None 0 0 None 0 0 2.40129E-06 0 0
A/V 24099 Ig-131 71 rs781721483 0.0889 -0.238 0.645 N 0.601 0.232 0.430010490656 gnomAD-2.1.1 2.82E-05 None None None None N None 0 1.74601E-04 None 0 0 None 0 None 0 8.89E-06 0
A/V 24099 Ig-131 71 rs781721483 0.0889 -0.238 0.645 N 0.601 0.232 0.430010490656 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
A/V 24099 Ig-131 71 rs781721483 0.0889 -0.238 0.645 N 0.601 0.232 0.430010490656 gnomAD-4.0.0 1.15533E-05 None None None None N None 0 1.35856E-04 None 0 0 None 0 0 2.39875E-06 0 0
K/T 24496 Ig-132 66 rs1035751709 0.7881 None 0.999 N 0.703 0.522 0.452928561435 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/T 24496 Ig-132 66 rs1035751709 0.7881 None 0.999 N 0.703 0.522 0.452928561435 gnomAD-4.0.0 6.57609E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47076E-05 0 0
N/H 25181 Ig-134 71 None 0.0732 None None N 0.113 0.187 0.239305524855 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/L 25867 Ig-136 70 rs1706845925 0.058 None None N 0.227 0.159 0.363751660372 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
Q/L 25867 Ig-136 70 rs1706845925 0.058 None None N 0.227 0.159 0.363751660372 gnomAD-4.0.0 6.57471E-06 None None None None N None 2.41371E-05 0 None 0 0 None 0 0 0 0 0
Q/P 25867 Ig-136 70 None 0.1243 None 0.065 N 0.454 0.226 0.284150004643 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
Q/E 26263 Ig-137 71 None 0.1029 None 0.309 N 0.499 0.239 0.203808441222 gnomAD-4.0.0 2.07367E-06 None None None None I None 0 0 None 0 0 None 0 0 2.71099E-06 0 0
Q/H 26263 Ig-137 71 rs770600641 0.1884 -0.489 0.939 N 0.56 0.417 0.303123707472 gnomAD-2.1.1 4.27E-06 None None None None I None 0 0 None 0 0 None 3.72E-05 None 0 0 0
Q/H 26263 Ig-137 71 rs770600641 0.1884 -0.489 0.939 N 0.56 0.417 0.303123707472 gnomAD-4.0.0 1.62789E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.50385E-05 0
K/I 26949 Ig-139 70 rs775669416 0.1639 0.326 0.97 D 0.759 0.522 0.705868728084 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
K/I 26949 Ig-139 70 rs775669416 0.1639 0.326 0.97 D 0.759 0.522 0.705868728084 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/I 26949 Ig-139 70 rs775669416 0.1639 0.326 0.97 D 0.759 0.522 0.705868728084 gnomAD-4.0.0 3.04492E-06 None None None None N None 0 0 None 0 0 None 0 0 3.61481E-06 0 0
R/L 27743 Ig-141 68 None 0.6278 None 0.846 N 0.505 0.307 0.682070973213 gnomAD-4.0.0 6.84351E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99541E-07 0 0
R/Q 27743 Ig-141 68 rs768262273 0.2553 -0.26 0.924 N 0.501 0.216 0.255270683199 gnomAD-2.1.1 2.42E-05 None None None None I None 0 0 None 0 1.12296E-04 None 0 None 0 3.56E-05 0
R/Q 27743 Ig-141 68 rs768262273 0.2553 -0.26 0.924 N 0.501 0.216 0.255270683199 gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
R/Q 27743 Ig-141 68 rs768262273 0.2553 -0.26 0.924 N 0.501 0.216 0.255270683199 gnomAD-4.0.0 1.30171E-05 None None None None I None 1.33601E-05 0 None 0 6.70451E-05 None 0 0 1.35629E-05 0 1.60195E-05
R/W 27743 Ig-141 68 rs1185542536 0.5872 -0.389 0.999 N 0.513 0.46 0.614776886339 gnomAD-2.1.1 8.06E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 8.91E-06 0
R/W 27743 Ig-141 68 rs1185542536 0.5872 -0.389 0.999 N 0.513 0.46 0.614776886339 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/W 27743 Ig-141 68 rs1185542536 0.5872 -0.389 0.999 N 0.513 0.46 0.614776886339 gnomAD-4.0.0 7.43828E-06 None None None None I None 2.67123E-05 0 None 0 0 None 0 0 7.62916E-06 1.09844E-05 0
R/K 29114 Ig-145 70 rs1253866874 0.0692 -1.277 None N 0.151 0.095 None gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
R/K 29114 Ig-145 70 rs1253866874 0.0692 -1.277 None N 0.151 0.095 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
R/K 29114 Ig-145 70 rs1253866874 0.0692 -1.277 None N 0.151 0.095 None gnomAD-4.0.0 1.11547E-05 None None None None I None 0 0 None 0 0 None 0 0 1.35612E-05 0 3.20205E-05
C/W 29510 Ig-146 67 rs1396298450 0.1792 -0.995 0.258 D 0.533 0.127 0.627302349016 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 0 0
K/E 29909 Ig-147 68 rs769543331 0.5276 0.74 0.999 N 0.655 0.477 0.425499470309 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
K/E 29909 Ig-147 68 rs769543331 0.5276 0.74 0.999 N 0.655 0.477 0.425499470309 gnomAD-4.0.0 1.11393E-05 None None None None N None 0 0 None 0 0 None 0 0 2.00079E-05 0 0
K/N 30201 Ig-148 70 rs931505367 0.2825 None 0.998 N 0.663 0.334 0.292062946507 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
K/N 30201 Ig-148 70 rs931505367 0.2825 None 0.998 N 0.663 0.334 0.292062946507 gnomAD-4.0.0 1.31435E-05 None None None None N None 4.82509E-05 0 None 0 0 None 0 0 0 0 0
V/A 30596 Ig-149 65 None 0.1157 None 0.027 N 0.493 0.173 0.59408574423 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
K/N 30993 Ig-150 67 rs754893239 0.9068 None 0.884 D 0.371 0.231 0.215869574891 gnomAD-4.0.0 1.36836E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79889E-06 0 0
K/R 32082 Ig-153 66 rs1388102991 0.0952 None 0.999 N 0.611 0.364 0.399017061211 gnomAD-4.0.0 4.77426E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57608E-06 0 0
T/I 32772 Ig-155 65 rs1163729764 0.1248 0.099 0.002 N 0.32 0.124 0.331876078066 gnomAD-2.1.1 1.21E-05 None None None None N None 0 5.8E-05 None 0 5.57E-05 None 0 None 0 0 0
T/I 32772 Ig-155 65 rs1163729764 0.1248 0.099 0.002 N 0.32 0.124 0.331876078066 gnomAD-4.0.0 4.77359E-06 None None None None N None 0 4.57331E-05 None 0 2.77331E-05 None 0 0 0 0 0
K/E 33267 Ig-157 65 None 0.2993 None 0.306 N 0.505 0.244 0.298745278005 gnomAD-4.0.0 1.60197E-06 None None None None N None 0 0 None 0 0 None 0 0 2.88311E-06 0 0
F/L 33666 Ig-159 71 rs752263533 0.956 -1.024 0.983 N 0.585 0.43 0.502691689211 gnomAD-2.1.1 2.82E-05 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 5.34E-05 0
F/L 33666 Ig-159 71 rs752263533 0.956 -1.024 0.983 N 0.585 0.43 0.502691689211 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
F/L 33666 Ig-159 71 rs752263533 0.956 -1.024 0.983 N 0.585 0.43 0.502691689211 gnomAD-4.0.0 3.90422E-05 None None None None N None 0 0 None 0 0 None 0 0 4.32285E-05 1.09794E-04 3.20215E-05
T/I 34206 Ig-160 70 rs767516936 0.3404 -0.362 0.051 N 0.279 0.153 0.350088858571 gnomAD-2.1.1 8.03E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
T/I 34206 Ig-160 70 rs767516936 0.3404 -0.362 0.051 N 0.279 0.153 0.350088858571 gnomAD-4.0.0 1.59103E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
E/K 34330 Ig-161 73 None 0.3812 None 0.969 N 0.575 0.361 0.421427970867 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
Y/N 34433 Ig-162 71 None 0.348 None 0.973 N 0.583 0.278 0.7264753701 gnomAD-4.0.0 1.59113E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85768E-06 0 0
T/A 35011 Ig-163 70 rs533966614 0.4195 -1.118 0.999 N 0.58 0.257 0.434934176536 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
T/A 35011 Ig-163 70 rs533966614 0.4195 -1.118 0.999 N 0.58 0.257 0.434934176536 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/A 35011 Ig-163 70 rs533966614 0.4195 -1.118 0.999 N 0.58 0.257 0.434934176536 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
T/A 35011 Ig-163 70 rs533966614 0.4195 -1.118 0.999 N 0.58 0.257 0.434934176536 gnomAD-4.0.0 3.71752E-06 None None None None N None 2.66581E-05 0 None 0 0 None 0 0 3.39015E-06 0 0
N/D 35198 Ig-164 70 rs1363509929 0.1234 -1.386 0.005 N 0.407 0.121 0.20549828249 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
N/D 35198 Ig-164 70 rs1363509929 0.1234 -1.386 0.005 N 0.407 0.121 0.20549828249 gnomAD-4.0.0 1.59089E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85749E-06 0 0
N/K 35198 Ig-164 70 rs1165290743 0.2102 0.035 0.005 N 0.383 0.119 0.126345400529 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 5.56E-05 None 0 None 0 0 0
N/K 35198 Ig-164 70 rs1165290743 0.2102 0.035 0.005 N 0.383 0.119 0.126345400529 gnomAD-4.0.0 6.84141E-07 None None None None N None 0 0 None 0 2.51889E-05 None 0 0 0 0 0
N/S 35198 Ig-164 70 None 0.0675 None None N 0.141 0.138 0.0401082797425 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/D 35356 Ig-165 71 None 0.1837 None 0.014 N 0.371 0.054 0.269111216191 gnomAD-4.0.0 1.36828E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79879E-06 0 0
E/K 35356 Ig-165 71 rs886055218 0.1804 -0.304 0.058 N 0.39 0.201 0.272205846399 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
E/K 35356 Ig-165 71 rs886055218 0.1804 -0.304 0.058 N 0.39 0.201 0.272205846399 gnomAD-4.0.0 1.36829E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99397E-07 0 1.6564E-05
L/H 35489 Ig-166 70 rs767087308 0.2166 -1.03 0.999 N 0.744 0.289 0.832902513328 gnomAD-2.1.1 4.09E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
L/H 35489 Ig-166 70 rs767087308 0.2166 -1.03 0.999 N 0.744 0.289 0.832902513328 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/H 35489 Ig-166 70 rs767087308 0.2166 -1.03 0.999 N 0.744 0.289 0.832902513328 gnomAD-4.0.0 9.01121E-06 None None None None N None 0 0 None 0 0 None 0 0 1.67834E-05 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.