Structural position:

  • Domain Type: Ig
  • Aligned Position: 155
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand F

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
S/F 79 Ig-1 74 None 0.2569 None 0.999 N 0.759 0.508 0.519946186488 gnomAD-4.0.0 2.73624E-06 None None None -0.255(TCAP) N None 0 0 None 0 0 None 0 6.93722E-04 0 0 0
S/T 79 Ig-1 74 rs746487470 0.1057 0.247 0.076 N 0.479 0.182 0.0716867268079 gnomAD-2.1.1 3.98E-06 None None None -0.622(TCAP) N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/T 79 Ig-1 74 rs746487470 0.1057 0.247 0.076 N 0.479 0.182 0.0716867268079 gnomAD-4.0.0 1.59045E-06 None None None -0.622(TCAP) N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
S/Y 79 Ig-1 74 None 0.2652 None 1.0 N 0.759 0.468 0.487772906946 gnomAD-4.0.0 6.8406E-07 None None None -0.029(TCAP) N None 0 0 None 0 0 None 0 0 8.9929E-07 0 0
T/A 1155 Ig-4 74 rs755080553 0.1839 -1.633 0.4 N 0.458 0.191 0.266843984389 gnomAD-2.1.1 7.97E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.76E-05 0
T/A 1155 Ig-4 74 rs755080553 0.1839 -1.633 0.4 N 0.458 0.191 0.266843984389 gnomAD-4.0.0 2.05235E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69799E-06 0 0
T/I 1155 Ig-4 74 rs1385838473 0.3823 None 0.997 N 0.651 0.527 0.474248596982 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 1155 Ig-4 74 rs1385838473 0.3823 None 0.997 N 0.651 0.527 0.474248596982 gnomAD-4.0.0 9.29403E-06 None None None None I None 0 0 None 0 0 None 0 0 1.10172E-05 0 3.20082E-05
T/A 1363 Ig-5 73 rs768249663 0.851 -1.379 0.999 N 0.599 0.504 None gnomAD-2.1.1 2.13E-05 None None None None N None 0 2.82E-05 None 0 0 None 0 None 0 3.89E-05 0
T/A 1363 Ig-5 73 rs768249663 0.851 -1.379 0.999 N 0.599 0.504 None gnomAD-3.1.2 3.94E-05 None None None None N None 0 0 0 0 0 None 0 0 8.82E-05 0 0
T/A 1363 Ig-5 73 rs768249663 0.851 -1.379 0.999 N 0.599 0.504 None gnomAD-4.0.0 7.2494E-05 None None None None N None 1.3349E-05 0 None 0 0 None 0 0 9.40715E-05 0 8.0023E-05
T/I 1529 Ig-6 73 None 0.2259 None 0.009 D 0.38 0.411 0.497021753114 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/S 1529 Ig-6 73 None 0.1606 None 0.379 N 0.482 0.237 0.289098819767 gnomAD-4.0.0 1.36832E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99344E-07 0 1.65623E-05
T/A 1629 Ig-7 74 None 0.7543 None 0.999 D 0.596 0.528 0.264547087235 gnomAD-4.0.0 1.59077E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02224E-05
T/I 1629 Ig-7 74 None 0.8894 None 1.0 D 0.799 0.523 0.504113619024 gnomAD-4.0.0 1.59084E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85665E-06 0 0
K/T 1911 Ig-9 71 rs1473622038 0.2562 None 0.722 N 0.493 0.145 0.148003135375 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/T 1911 Ig-9 71 rs1473622038 0.2562 None 0.722 N 0.493 0.145 0.148003135375 gnomAD-4.0.0 6.56978E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4699E-05 0 0
M/T 2150 Ig-10 73 rs761352132 0.4855 -1.198 0.994 N 0.485 0.573 0.726484281749 gnomAD-2.1.1 1.59E-05 None None None None N None 6.15E-05 0 None 9.94E-05 0 None 0 None 0 1.76E-05 0
M/T 2150 Ig-10 73 rs761352132 0.4855 -1.198 0.994 N 0.485 0.573 0.726484281749 gnomAD-3.1.2 2.63E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 2.94E-05 0 0
M/T 2150 Ig-10 73 rs761352132 0.4855 -1.198 0.994 N 0.485 0.573 0.726484281749 gnomAD-4.0.0 1.92074E-05 None None None None N None 4.00459E-05 0 None 3.37792E-05 0 None 0 0 2.20335E-05 0 1.60056E-05
M/V 2150 Ig-10 73 None 0.3425 None 0.985 N 0.549 0.38 0.686849864873 gnomAD-4.0.0 4.77202E-06 None None None None N None 0 0 None 0 0 None 0 0 8.56957E-06 0 0
S/G 2245 Ig-11 72 None 0.1526 None 0.994 N 0.629 0.184 0.15556083564 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
S/N 2245 Ig-11 72 rs749033972 0.2399 -0.538 0.994 N 0.651 0.223 0.146414634003 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
S/G 2337 Ig-12 71 None 0.1373 None 0.815 N 0.615 0.205 0.198526703765 gnomAD-4.0.0 1.59057E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
S/C 2426 Ig-13 71 None 0.1099 None 1.0 D 0.819 0.642 0.811379597274 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/N 2516 Ig-14 72 rs200973013 0.5618 None 0.075 D 0.477 0.205 0.0716867268079 gnomAD-4.0.0 6.3629E-06 None None None None N None 0 0 None 0 0 None 0 0 1.14272E-05 0 0
T/A 2603 Ig-15 71 rs775528928 0.0936 -1.499 None N 0.269 0.082 0.218112801441 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
T/A 2603 Ig-15 71 rs775528928 0.0936 -1.499 None N 0.269 0.082 0.218112801441 gnomAD-4.0.0 1.0263E-05 None None None None N None 0 0 None 0 0 None 0 0 1.34905E-05 0 0
T/I 2603 Ig-15 71 None 0.1193 None None N 0.477 0.14 0.289098819767 gnomAD-4.0.0 1.59113E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43316E-05 0
T/I 2690 Ig-16 70 rs374620001 0.228 -0.131 0.991 N 0.76 0.261 None gnomAD-2.1.1 5.76795E-04 None None None None N None 0 0 None 0 7.29083E-03 None 4.89972E-04 None 0 0 4.15397E-04
T/I 2690 Ig-16 70 rs374620001 0.228 -0.131 0.991 N 0.76 0.261 None gnomAD-3.1.2 3.02313E-04 None None None None N None 0 6.55E-05 0 0 7.14838E-03 None 0 0 1.47E-05 1.44808E-03 0
T/I 2690 Ig-16 70 rs374620001 0.228 -0.131 0.991 N 0.76 0.261 None 1000 genomes 1.79712E-03 None None None None N None 0 0 None None 7.9E-03 0 None None None 1E-03 None
T/I 2690 Ig-16 70 rs374620001 0.228 -0.131 0.991 N 0.76 0.261 None gnomAD-4.0.0 2.10646E-04 None None None None N None 0 3.33322E-05 None 0 5.62073E-03 None 0 0 5.0847E-06 5.81868E-04 4.31959E-04
G/A 2778 Ig-17 72 rs767274457 0.0989 None 0.64 N 0.609 0.39 0.47282010386 gnomAD-4.0.0 6.84073E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99294E-07 0 0
G/D 2778 Ig-17 72 None 0.5395 -1.053 0.811 D 0.688 0.547 0.619048737305 gnomAD-2.1.1 1.59E-05 None None None None N None 0 0 None 0 0 None 1.30659E-04 None 0 0 0
G/D 2778 Ig-17 72 None 0.5395 -1.053 0.811 D 0.688 0.547 0.619048737305 gnomAD-4.0.0 6.84073E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69788E-06 8.11519E-05 0
T/I 2865 Ig-18 71 rs2091254998 0.1834 None 0.991 N 0.783 0.286 0.41337360676 gnomAD-4.0.0 2.05219E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69788E-06 0 0
T/R 2865 Ig-18 71 None 0.2024 None 0.1 N 0.505 0.307 0.50539470866 gnomAD-4.0.0 6.84064E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99292E-07 0 0
T/A 2952 Ig-19 71 rs879010411 0.2355 -1.699 0.999 D 0.521 0.6 0.527356302626 gnomAD-2.1.1 4E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
T/A 2952 Ig-19 71 rs879010411 0.2355 -1.699 0.999 D 0.521 0.6 0.527356302626 gnomAD-4.0.0 1.59101E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85742E-06 0 0
T/I 2952 Ig-19 71 rs1236189232 0.4106 None 1.0 D 0.829 0.616 0.777943573247 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
T/I 2952 Ig-19 71 rs1236189232 0.4106 None 1.0 D 0.829 0.616 0.777943573247 gnomAD-4.0.0 1.15303E-05 None None None None N None 1.69216E-05 0 None 0 1.6973E-04 None 0 0 2.39261E-06 0 0
T/I 3039 Ig-20 71 rs774523194 0.2418 -0.199 0.896 N 0.725 0.161 0.379881503574 gnomAD-2.1.1 1.99E-05 None None None None N None 0 1.15734E-04 None 0 0 None 0 None 0 0 1.63185E-04
T/I 3039 Ig-20 71 rs774523194 0.2418 -0.199 0.896 N 0.725 0.161 0.379881503574 gnomAD-3.1.2 3.29E-05 None None None None N None 0 2.62055E-04 0 0 0 None 0 0 1.47E-05 0 0
T/I 3039 Ig-20 71 rs774523194 0.2418 -0.199 0.896 N 0.725 0.161 0.379881503574 gnomAD-4.0.0 1.28069E-05 None None None None N None 0 1.35607E-04 None 0 0 None 0 0 2.39172E-06 0 2.84204E-05
T/N 3039 Ig-20 71 None 0.2892 -0.746 0.379 D 0.679 0.186 0.31077124679 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.8E-06 0
T/S 3039 Ig-20 71 rs774523194 0.1334 -1.139 0.007 N 0.293 0.154 0.107399877778 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/S 3039 Ig-20 71 rs774523194 0.1334 -1.139 0.007 N 0.293 0.154 0.107399877778 gnomAD-4.0.0 1.59066E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
T/N 3219 Ig-22 73 rs1385851793 0.5435 -1.183 1.0 N 0.72 0.342 0.324161360171 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/N 3219 Ig-22 73 rs1385851793 0.5435 -1.183 1.0 N 0.72 0.342 0.324161360171 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
T/N 3219 Ig-22 73 rs1385851793 0.5435 -1.183 1.0 N 0.72 0.342 0.324161360171 gnomAD-4.0.0 2.72623E-05 None None None None N None 0 0 None 0 0 None 0 0 3.64414E-05 0 1.60051E-05
T/I 3310 Ig-23 72 rs1433903188 0.2556 None 0.988 D 0.574 0.476 0.718529551479 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 3310 Ig-23 72 rs1433903188 0.2556 None 0.988 D 0.574 0.476 0.718529551479 gnomAD-4.0.0 4.337E-06 None None None None N None 0 0 None 0 0 None 0 0 4.23726E-06 1.09786E-05 1.60036E-05
T/N 3310 Ig-23 72 None 0.2899 -0.427 0.061 D 0.22 0.306 0.494366844524 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
T/N 3310 Ig-23 72 None 0.2899 -0.427 0.061 D 0.22 0.306 0.494366844524 gnomAD-4.0.0 4.337E-06 None None None None N None 0 0 None 0 0 None 0 0 5.93216E-06 0 0
T/S 3310 Ig-23 72 rs1433903188 0.1914 -0.799 0.31 N 0.251 0.316 0.288352970974 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 2.87687E-04 0 0
T/S 3310 Ig-23 72 rs1433903188 0.1914 -0.799 0.31 N 0.251 0.316 0.288352970974 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 1.88466E-04 0 0 0 0
T/S 3310 Ig-23 72 rs1433903188 0.1914 -0.799 0.31 N 0.251 0.316 0.288352970974 gnomAD-4.0.0 1.31413E-05 None None None None N None 0 0 None 0 0 None 1.88466E-04 0 0 0 0
T/M 3415 Ig-24 71 rs761799688 0.1359 -1.036 0.977 D 0.728 0.496 0.819533414578 gnomAD-2.1.1 1.55333E-04 None None None None N None 6.15E-05 1.09896E-03 None 0 0 None 0 None 0 0 0
T/M 3415 Ig-24 71 rs761799688 0.1359 -1.036 0.977 D 0.728 0.496 0.819533414578 gnomAD-3.1.2 1.97E-05 None None None None N None 0 1.96721E-04 0 0 0 None 0 0 0 0 0
T/M 3415 Ig-24 71 rs761799688 0.1359 -1.036 0.977 D 0.728 0.496 0.819533414578 gnomAD-4.0.0 2.91229E-05 None None None None N None 1.33497E-05 6.3365E-04 None 0 0 None 0 0 3.39003E-06 0 6.40205E-05
T/S 3415 Ig-24 71 rs1488856141 0.147 -1.154 0.011 N 0.466 0.249 0.21737058555 gnomAD-2.1.1 7.97E-06 None None None None N None 0 5.78E-05 None 0 0 None 0 None 0 0 0
T/S 3415 Ig-24 71 rs1488856141 0.147 -1.154 0.011 N 0.466 0.249 0.21737058555 gnomAD-4.0.0 3.18149E-06 None None None None N None 0 4.57289E-05 None 0 0 None 0 0 0 0 0
S/G 3731 Ig-26 72 None 0.1552 None None None None 0.099 None gnomAD-4.0.0 1.59122E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
S/N 3731 Ig-26 72 None 0.2005 None None None None 0.186 None gnomAD-4.0.0 1.59126E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
S/R 3731 Ig-26 72 None 0.4453 None None None None 0.044 None gnomAD-4.0.0 1.59124E-06 None None None None N None 0 0 None 0 2.773E-05 None 0 0 0 0 0
T/I 3891 Ig-27 72 rs148164929 0.1825 -0.071 0.029 N 0.698 0.114 None gnomAD-2.1.1 5.10911E-04 None None None None N None 1.90208E-03 9.33839E-04 None 1.74115E-03 0 None 0 None 4E-05 3.05121E-04 8.4317E-04
T/I 3891 Ig-27 72 rs148164929 0.1825 -0.071 0.029 N 0.698 0.114 None gnomAD-3.1.2 8.48126E-04 None None None None N None 1.97962E-03 1.24574E-03 0 1.72911E-03 0 None 0 0 3.08705E-04 0 4.78469E-04
T/I 3891 Ig-27 72 rs148164929 0.1825 -0.071 0.029 N 0.698 0.114 None 1000 genomes 1.19808E-03 None None None None N None 1.5E-03 2.9E-03 None None 0 2E-03 None None None 0 None
T/I 3891 Ig-27 72 rs148164929 0.1825 -0.071 0.029 N 0.698 0.114 None gnomAD-4.0.0 2.91238E-04 None None None None N None 1.85299E-03 9.3352E-04 None 1.58773E-03 0 None 0 1.15512E-03 1.55957E-04 0 5.9219E-04
T/K 3891 Ig-27 72 None 0.2494 None 0.029 N 0.697 0.127 None gnomAD-4.0.0 2.05257E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69835E-06 0 0
T/A 4771 Ig-30 72 None 0.15 None 0.273 N 0.551 0.215 0.252681307341 gnomAD-4.0.0 1.59131E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8583E-06 0 0
T/I 4771 Ig-30 72 rs762249414 0.251 0.183 0.864 N 0.642 0.165 0.366848117066 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
T/I 4771 Ig-30 72 rs762249414 0.251 0.183 0.864 N 0.642 0.165 0.366848117066 gnomAD-4.0.0 3.18269E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85834E-06 0 3.02425E-05
S/F 4866 Ig-31 72 rs1226951123 0.2309 -0.701 0.642 N 0.729 0.272 0.532020707701 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
S/F 4866 Ig-31 72 rs1226951123 0.2309 -0.701 0.642 N 0.729 0.272 0.532020707701 gnomAD-4.0.0 3.18256E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71608E-06 0 0
S/Y 4866 Ig-31 72 None 0.2125 None 0.975 N 0.727 0.307 0.548779645056 gnomAD-4.0.0 1.59128E-06 None None None None N None 0 2.28686E-05 None 0 0 None 0 0 0 0 0
S/L 5053 Ig-33 73 None 0.1086 None 0.811 N 0.632 0.252 0.529611391303 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
S/P 5053 Ig-33 73 None 0.9803 None 0.984 N 0.617 0.302 0.258779203287 gnomAD-4.0.0 1.59179E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8592E-06 0 0
T/K 5239 Ig-35 72 rs756844952 0.2659 -0.278 0.995 D 0.625 0.308 0.441324992753 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/K 5239 Ig-35 72 rs756844952 0.2659 -0.278 0.995 D 0.625 0.308 0.441324992753 gnomAD-4.0.0 6.84295E-07 None None None None N None 0 2.23654E-05 None 0 0 None 0 0 0 0 0
T/M 5239 Ig-35 72 rs756844952 0.1074 -0.178 0.998 D 0.646 0.357 None gnomAD-2.1.1 1.43E-05 None None None None N None 4.13E-05 0 None 0 0 None 0 None 0 2.35E-05 0
T/M 5239 Ig-35 72 rs756844952 0.1074 -0.178 0.998 D 0.646 0.357 None gnomAD-3.1.2 3.29E-05 None None None None N None 4.83E-05 6.55E-05 0 0 0 None 0 0 2.94E-05 0 0
T/M 5239 Ig-35 72 rs756844952 0.1074 -0.178 0.998 D 0.646 0.357 None gnomAD-4.0.0 2.16923E-05 None None None None N None 2.67065E-05 1.66739E-05 None 0 2.22886E-05 None 0 0 2.37357E-05 2.19616E-05 1.60133E-05
T/R 5239 Ig-35 72 None 0.1916 None 0.998 D 0.637 0.335 0.500176316166 gnomAD-4.0.0 6.84295E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99583E-07 0 0
T/I 5332 Ig-36 72 rs1232516805 0.1362 None 0.051 N 0.514 0.262 0.313210971179 gnomAD-4.0.0 4.10644E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39809E-06 0 0
T/A 5428 Ig-37 72 None 0.1214 None 0.047 N 0.371 0.198 0.186928172975 gnomAD-4.0.0 1.59287E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86005E-06 0 0
T/A 5521 Ig-38 72 rs777565819 0.1045 -1.221 0.051 N 0.332 0.265 0.190952846119 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/A 5521 Ig-38 72 rs777565819 0.1045 -1.221 0.051 N 0.332 0.265 0.190952846119 gnomAD-4.0.0 1.36857E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79906E-06 0 0
T/I 5521 Ig-38 72 None 0.0992 None 0.012 N 0.467 0.224 0.362960570912 gnomAD-4.0.0 6.84278E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99517E-07 0 0
T/K 5521 Ig-38 72 None 0.2154 None 0.801 N 0.707 0.262 0.419835214384 gnomAD-4.0.0 6.84278E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99517E-07 0 0
T/R 5521 Ig-38 72 None 0.1473 None 0.934 N 0.695 0.256 0.565131857978 gnomAD-4.0.0 1.36856E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99517E-07 1.1598E-05 0
M/I 5615 Ig-39 73 None 0.2276 None 0.001 N 0.21 0.164 0.29132392195 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
M/L 5615 Ig-39 73 rs1392126225 0.1209 None 0.001 N 0.185 0.154 0.429666569261 gnomAD-4.0.0 1.59146E-06 None None None None N None 5.65675E-05 0 None 0 0 None 0 0 0 0 0
M/T 5615 Ig-39 73 rs760133132 0.1006 -1.192 0.01 N 0.379 0.284 None gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.56E-05 0
M/T 5615 Ig-39 73 rs760133132 0.1006 -1.192 0.01 N 0.379 0.284 None gnomAD-3.1.2 3.94E-05 None None None None N None 4.82E-05 0 0 0 0 None 9.42E-05 0 4.41E-05 0 0
M/T 5615 Ig-39 73 rs760133132 0.1006 -1.192 0.01 N 0.379 0.284 None gnomAD-4.0.0 1.23944E-05 None None None None N None 4.00416E-05 0 None 0 0 None 1.56226E-05 0 1.35624E-05 0 0
Q/H 5708 Ig-40 72 rs373282814 0.147 -1.067 0.998 N 0.487 0.216 0.261217442401 gnomAD-2.1.1 1.07E-05 None None None None I None 1.24018E-04 0 None 0 0 None 0 None 0 0 0
Q/H 5708 Ig-40 72 rs373282814 0.147 -1.067 0.998 N 0.487 0.216 0.261217442401 gnomAD-3.1.2 5.91E-05 None None None None I None 2.17171E-04 0 0 0 0 None 0 0 0 0 0
Q/H 5708 Ig-40 72 rs373282814 0.147 -1.067 0.998 N 0.487 0.216 0.261217442401 gnomAD-4.0.0 6.84231E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15947E-05 0
V/I 5801 Ig-41 72 rs556053351 0.0641 -0.431 None N 0.261 0.069 0.224531998449 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 5801 Ig-41 72 rs556053351 0.0641 -0.431 None N 0.261 0.069 0.224531998449 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
V/I 5801 Ig-41 72 rs556053351 0.0641 -0.431 None N 0.261 0.069 0.224531998449 gnomAD-4.0.0 6.56797E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4702E-05 0 0
T/A 5990 Ig-43 72 rs570762307 0.1155 -1.532 0.977 N 0.594 0.335 0.264081493735 gnomAD-2.1.1 8.04E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 8.88E-06 0
T/A 5990 Ig-43 72 rs570762307 0.1155 -1.532 0.977 N 0.594 0.335 0.264081493735 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
T/A 5990 Ig-43 72 rs570762307 0.1155 -1.532 0.977 N 0.594 0.335 0.264081493735 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
T/A 5990 Ig-43 72 rs570762307 0.1155 -1.532 0.977 N 0.594 0.335 0.264081493735 gnomAD-4.0.0 5.57748E-06 None None None None N None 1.33287E-05 1.66672E-05 None 0 0 None 0 0 4.23859E-06 2.19602E-05 0
T/P 5990 Ig-43 72 rs570762307 0.8867 -0.792 0.999 D 0.757 0.363 0.553063759574 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
T/P 5990 Ig-43 72 rs570762307 0.8867 -0.792 0.999 D 0.757 0.363 0.553063759574 gnomAD-4.0.0 6.84297E-07 None None None None N None 0 0 None 0 2.51978E-05 None 0 0 0 0 0
I/T 6083 Ig-44 72 None 0.1083 None 0.003 N 0.333 0.17 0.294561560033 gnomAD-4.0.0 1.59216E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85927E-06 0 0
I/V 6083 Ig-44 72 rs374012753 0.0712 -1.1 0.003 N 0.175 0.072 None gnomAD-2.1.1 2.02E-05 None None None None N None 0 0 None 0 0 None 0 None 9.3E-05 2.67E-05 0
I/V 6083 Ig-44 72 rs374012753 0.0712 -1.1 0.003 N 0.175 0.072 None gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/V 6083 Ig-44 72 rs374012753 0.0712 -1.1 0.003 N 0.175 0.072 None gnomAD-4.0.0 1.7362E-05 None None None None N None 1.33819E-05 0 None 0 0 None 9.39291E-05 0 1.6956E-05 0 1.6022E-05
V/A 6177 Ig-45 73 rs2080061909 0.2215 None 0.954 N 0.602 0.19 0.668390147402 gnomAD-4.0.0 1.59135E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85856E-06 0 0
V/L 6177 Ig-45 73 None 0.2 None 0.91 N 0.58 0.206 0.611224490431 gnomAD-4.0.0 6.00161E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 3.66327E-05
V/M 6177 Ig-45 73 rs1553921514 0.14 None 0.998 N 0.612 0.286 0.63694057803 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
Q/P 6270 Ig-46 72 None 0.909 None 0.999 N 0.621 0.378 0.430126000877 gnomAD-4.0.0 1.59194E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85968E-06 0 0
Q/R 6270 Ig-46 72 None 0.118 None 0.997 N 0.537 0.205 0.18274738541 gnomAD-4.0.0 1.59194E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85968E-06 0 0
T/A 6363 Ig-47 72 None 0.1246 None 0.174 N 0.627 0.291 0.351614576976 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.21507E-04 0
T/I 6363 Ig-47 72 rs148471999 0.1532 None 0.007 N 0.531 0.168 0.284150004643 gnomAD-4.0.0 1.30096E-05 None None None None N None 0 0 None 0 0 None 0 0 1.52964E-05 1.16149E-05 1.65821E-05
T/N 6363 Ig-47 72 rs148471999 0.3079 None 0.642 N 0.701 0.227 0.402899589544 gnomAD-4.0.0 6.84714E-07 None None None None N None 2.99007E-05 0 None 0 0 None 0 0 0 0 0
T/S 6363 Ig-47 72 rs1560766830 0.1571 None 0.003 N 0.347 0.207 0.185906805712 gnomAD-4.0.0 6.84714E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65821E-05
T/N 6456 Ig-48 72 None 0.1888 None 0.642 N 0.539 0.322 0.372087925617 gnomAD-4.0.0 6.84534E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99713E-07 0 0
T/S 6456 Ig-48 72 None 0.1224 None 0.01 N 0.211 0.075 0.202949470691 gnomAD-4.0.0 2.0536E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69914E-06 0 0
T/A 6645 Ig-50 72 rs370671112 0.0993 -1.186 0.925 N 0.615 0.258 None gnomAD-2.1.1 2.54E-05 None None None None N None 0 0 None 0 0 None 3.4E-05 None 0 4.74E-05 0
T/A 6645 Ig-50 72 rs370671112 0.0993 -1.186 0.925 N 0.615 0.258 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
T/A 6645 Ig-50 72 rs370671112 0.0993 -1.186 0.925 N 0.615 0.258 None gnomAD-4.0.0 2.36301E-05 None None None None N None 0 0 None 0 0 None 0 0 3.05744E-05 1.11349E-05 1.60658E-05
I/T 6926 Ig-53 73 rs1430184680 0.1496 -2.656 0.003 N 0.419 0.147 0.32082282376 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 3.31E-05 None 0 0 0
I/T 6926 Ig-53 73 rs1430184680 0.1496 -2.656 0.003 N 0.419 0.147 0.32082282376 gnomAD-4.0.0 2.74155E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.66027E-05 0
I/V 6926 Ig-53 73 rs752400157 0.0746 -1.605 0.001 N 0.257 0.032 0.406668915854 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 5.61E-05 None 0 None 0 0 0
I/V 6926 Ig-53 73 rs752400157 0.0746 -1.605 0.001 N 0.257 0.032 0.406668915854 gnomAD-4.0.0 1.59728E-06 None None None None N None 0 0 None 0 2.78025E-05 None 0 0 0 0 0
T/P 7019 Ig-54 72 rs1310121479 0.8487 -0.453 0.999 N 0.747 0.468 0.51748813702 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/P 7019 Ig-54 72 rs1310121479 0.8487 -0.453 0.999 N 0.747 0.468 0.51748813702 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/P 7019 Ig-54 72 rs1310121479 0.8487 -0.453 0.999 N 0.747 0.468 0.51748813702 gnomAD-4.0.0 1.2396E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69544E-06 0 0
T/S 7019 Ig-54 72 rs1310121479 0.1259 -1.081 0.992 N 0.538 0.232 0.211220785272 gnomAD-2.1.1 8.04E-06 None None None None N None 0 5.81E-05 None 0 0 None 0 None 0 0 0
T/S 7019 Ig-54 72 rs1310121479 0.1259 -1.081 0.992 N 0.538 0.232 0.211220785272 gnomAD-4.0.0 1.36866E-06 None None None None N None 0 2.23814E-05 None 0 0 None 0 0 8.99577E-07 0 0
T/K 7115 Ig-55 72 None 0.2758 None 0.79 N 0.468 0.358 0.418095516054 gnomAD-4.0.0 6.84364E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99658E-07 0 0
T/S 7115 Ig-55 72 None 0.1278 None 0.992 N 0.554 0.308 0.225215365344 gnomAD-4.0.0 1.59209E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8601E-06 0 0
T/I 7208 Ig-56 72 rs1250736680 0.2429 -0.273 0.961 N 0.647 0.357 0.467839254973 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
T/I 7208 Ig-56 72 rs1250736680 0.2429 -0.273 0.961 N 0.647 0.357 0.467839254973 gnomAD-4.0.0 2.05326E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69886E-06 0 0
T/N 7208 Ig-56 72 rs1250736680 0.2069 None 0.994 N 0.615 0.37 0.44318313171 gnomAD-4.0.0 2.73769E-06 None None None None N None 0 6.71652E-05 None 0 0 None 0 0 0 0 1.6575E-05
T/K 7394 Ig-58 72 None 0.2114 None 0.45 N 0.585 0.231 0.352262096564 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
S/C 7490 Ig-59 72 rs781659636 0.175 -0.898 0.997 N 0.683 0.384 0.799020525514 gnomAD-2.1.1 4.06E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
S/C 7490 Ig-59 72 rs781659636 0.175 -0.898 0.997 N 0.683 0.384 0.799020525514 gnomAD-4.0.0 1.59472E-06 None None None None N None 0 2.28938E-05 None 0 0 None 0 0 0 0 0
T/I 7586 Ig-60 72 None 0.0982 None 0.994 N 0.755 0.276 0.501685917333 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
I/L 7680 Ig-61 73 None 0.1484 None 0.267 N 0.431 0.105 0.462461958149 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
I/V 7680 Ig-61 73 None 0.0918 None 0.267 N 0.409 0.059 0.33340067248 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
H/Y 7773 Ig-62 72 rs777185633 0.077 0.873 None N 0.216 0.048 0.141422826196 gnomAD-2.1.1 1.21E-05 None None None None N None 0 8.69E-05 None 0 0 None 0 None 0 0 0
H/Y 7773 Ig-62 72 rs777185633 0.077 0.873 None N 0.216 0.048 0.141422826196 gnomAD-4.0.0 5.47414E-06 None None None None N None 0 8.94494E-05 None 0 0 None 0 0 1.79908E-06 0 3.31356E-05
I/M 7867 Ig-63 73 rs1334032406 0.1121 -1.16 0.171 N 0.573 0.054 0.257786959452 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/M 7867 Ig-63 73 rs1334032406 0.1121 -1.16 0.171 N 0.573 0.054 0.257786959452 gnomAD-4.0.0 2.73738E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99583E-07 3.47891E-05 0
I/T 7867 Ig-63 73 rs376689567 0.1073 -2.242 None N 0.363 0.078 None gnomAD-2.1.1 7.15E-06 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 0 0
I/T 7867 Ig-63 73 rs376689567 0.1073 -2.242 None N 0.363 0.078 None gnomAD-3.1.2 3.29E-05 None None None None N None 1.20651E-04 0 0 0 0 None 0 0 0 0 0
I/T 7867 Ig-63 73 rs376689567 0.1073 -2.242 None N 0.363 0.078 None gnomAD-4.0.0 3.28688E-05 None None None None N None 1.20651E-04 0 None 0 0 None 0 0 0 0 0
I/V 7867 Ig-63 73 rs1446627286 0.0638 -1.466 None N 0.2 0.031 0.200317383148 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/V 7867 Ig-63 73 rs1446627286 0.0638 -1.466 None N 0.2 0.031 0.200317383148 gnomAD-4.0.0 2.05301E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31943E-05 1.65722E-05
S/N 7960 Ig-64 72 rs369302142 0.182 0.177 0.055 N 0.555 0.175 None gnomAD-2.1.1 3.62E-05 None None None None N None 0 8.7E-05 None 1.99164E-04 0 None 0 None 0 2.67E-05 1.66223E-04
S/N 7960 Ig-64 72 rs369302142 0.182 0.177 0.055 N 0.555 0.175 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 2.88351E-04 0 None 0 0 0 0 4.78927E-04
S/N 7960 Ig-64 72 rs369302142 0.182 0.177 0.055 N 0.555 0.175 None gnomAD-4.0.0 1.7356E-05 None None None None N None 0 1.00037E-04 None 3.38043E-04 0 None 0 0 6.78252E-06 0 6.40718E-05
T/M 8056 Ig-65 72 rs757148743 0.1082 -0.385 1.0 N 0.685 0.326 0.632792546795 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.92E-06 0
T/M 8056 Ig-65 72 rs757148743 0.1082 -0.385 1.0 N 0.685 0.326 0.632792546795 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.43E-05 0 0 0 0
T/M 8056 Ig-65 72 rs757148743 0.1082 -0.385 1.0 N 0.685 0.326 0.632792546795 gnomAD-4.0.0 6.19669E-06 None None None None N None 0 1.66628E-05 None 0 0 None 1.5625E-05 0 5.08584E-06 1.09798E-05 1.60061E-05
T/S 8056 Ig-65 72 None 0.1103 None 0.775 N 0.53 0.163 0.185906805712 gnomAD-4.0.0 1.59131E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85847E-06 0 0
S/F 8149 Ig-66 72 None 0.256 None 0.984 N 0.751 0.434 0.591025817267 gnomAD-4.0.0 1.5913E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
S/P 8149 Ig-66 72 None 0.9284 None 0.984 N 0.651 0.356 0.26547132957 gnomAD-4.0.0 1.59129E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02425E-05
S/Y 8149 Ig-66 72 rs1278756355 0.2251 -0.378 0.995 N 0.756 0.388 0.586295999888 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/Y 8149 Ig-66 72 rs1278756355 0.2251 -0.378 0.995 N 0.756 0.388 0.586295999888 gnomAD-4.0.0 1.5913E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
S/G 8242 Ig-67 72 rs754820566 0.1218 -1.496 None N 0.179 0.088 0.220303561663 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
S/G 8242 Ig-67 72 rs754820566 0.1218 -1.496 None N 0.179 0.088 0.220303561663 gnomAD-4.0.0 6.84221E-07 None None None None N None 0 0 None 0 2.5194E-05 None 0 0 0 0 0
S/N 8242 Ig-67 72 None 0.1747 None 0.055 N 0.496 0.081 0.223847106136 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
S/R 8242 Ig-67 72 None 0.3314 None 0.055 N 0.674 0.114 0.27479166964 gnomAD-4.0.0 6.84221E-07 None None None None N None 2.98864E-05 0 None 0 0 None 0 0 0 0 0
S/A 8335 Ig-68 72 rs773006091 0.0858 -0.6 0.005 N 0.427 0.123 0.0401082797425 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
S/A 8335 Ig-68 72 rs773006091 0.0858 -0.6 0.005 N 0.427 0.123 0.0401082797425 gnomAD-4.0.0 6.84237E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99517E-07 0 0
S/T 8335 Ig-68 72 None 0.0523 None None N 0.203 0.093 0.0297737177859 gnomAD-4.0.0 6.84237E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99517E-07 0 0
T/I 8527 Ig-70 72 rs1560626573 0.1329 None 0.793 N 0.367 0.321 0.484763619824 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/I 8527 Ig-70 72 rs1560626573 0.1329 None 0.793 N 0.367 0.321 0.484763619824 gnomAD-4.0.0 2.7373E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59837E-06 0 0
T/I 8621 Ig-71 73 None 0.1386 None 0.998 N 0.763 0.229 0.406668915854 gnomAD-4.0.0 6.84286E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9957E-07 0 0
T/N 8621 Ig-71 73 rs899151063 0.2526 -1.338 0.98 N 0.72 0.314 0.381071309025 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
T/N 8621 Ig-71 73 rs899151063 0.2526 -1.338 0.98 N 0.72 0.314 0.381071309025 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/N 8621 Ig-71 73 rs899151063 0.2526 -1.338 0.98 N 0.72 0.314 0.381071309025 gnomAD-4.0.0 4.33843E-06 None None None None N None 0 0 None 0 0 None 0 0 5.93395E-06 0 0
Q/E 8714 Ig-72 72 None 0.0911 None None N 0.226 0.158 0.119812018005 gnomAD-4.0.0 1.59179E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85923E-06 0 0
Q/H 8714 Ig-72 72 rs2077266939 0.1004 None None N 0.275 0.146 0.0884992946249 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
T/A 8808 Ig-73 73 None 0.0851 None 0.089 N 0.663 0.278 0.322230723748 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
S/C 8901 Ig-74 72 rs1405906564 0.1257 None 0.78 N 0.641 0.229 0.353125101423 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
S/C 8901 Ig-74 72 rs1405906564 0.1257 None 0.78 N 0.641 0.229 0.353125101423 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/C 8901 Ig-74 72 rs1405906564 0.1257 None 0.78 N 0.641 0.229 0.353125101423 gnomAD-4.0.0 5.12501E-06 None None None None N None 0 0 None 0 0 None 0 0 9.57327E-06 0 0
S/G 8901 Ig-74 72 rs1405906564 0.1088 -1.751 0.052 N 0.564 0.15 0.137902524267 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
S/G 8901 Ig-74 72 rs1405906564 0.1088 -1.751 0.052 N 0.564 0.15 0.137902524267 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/G 8901 Ig-74 72 rs1405906564 0.1088 -1.751 0.052 N 0.564 0.15 0.137902524267 gnomAD-4.0.0 3.84376E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78664E-06 1.34041E-05 0
T/A 8997 Ig-75 72 rs953177976 0.089 None 0.454 N 0.407 0.218 0.228597637076 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
T/A 8997 Ig-75 72 rs953177976 0.089 None 0.454 N 0.407 0.218 0.228597637076 gnomAD-4.0.0 1.31406E-05 None None None None N None 4.82556E-05 0 None 0 0 None 0 0 0 0 0
T/I 8997 Ig-75 72 rs1259415133 0.1207 0.22 0.669 N 0.55 0.19 0.419461527279 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/I 8997 Ig-75 72 rs1259415133 0.1207 0.22 0.669 N 0.55 0.19 0.419461527279 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 8997 Ig-75 72 rs1259415133 0.1207 0.22 0.669 N 0.55 0.19 0.419461527279 gnomAD-4.0.0 6.57091E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46998E-05 0 0
T/R 8997 Ig-75 72 rs1259415133 0.087 -0.407 0.669 N 0.549 0.2 0.5253096542 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 0 0
T/R 8997 Ig-75 72 rs1259415133 0.087 -0.407 0.669 N 0.549 0.2 0.5253096542 gnomAD-4.0.0 3.18277E-06 None None None None N None 0 0 None 0 0 None 3.76563E-05 0 0 0 0
T/I 9090 Ig-76 72 None 0.2353 None 0.811 N 0.595 0.358 0.503248607038 gnomAD-4.0.0 4.77376E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57452E-06 0 0
I/L 9276 Ig-78 72 rs1289827097 0.1057 -0.566 0.316 N 0.413 0.058 0.385906861911 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/L 9276 Ig-78 72 rs1289827097 0.1057 -0.566 0.316 N 0.413 0.058 0.385906861911 gnomAD-4.0.0 6.56935E-06 None None None None N None 2.41196E-05 0 None 0 0 None 0 0 0 0 0
I/T 9276 Ig-78 72 None 0.0969 None 0.028 N 0.355 0.187 0.335910606209 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 9276 Ig-78 72 rs1289827097 0.0687 None 0.028 N 0.229 0.054 0.441740949975 gnomAD-4.0.0 1.36871E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99617E-07 1.16087E-05 0
T/I 9468 Ig-80 72 None 0.1946 None 0.317 None 0.735 0.186 0.442977140156 gnomAD-4.0.0 1.59206E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85804E-06 0 0
T/S 9468 Ig-80 72 rs1241585388 0.1163 None None None 0.271 0.044 0.17258766438 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
T/S 9468 Ig-80 72 rs1241585388 0.1163 None None None 0.271 0.044 0.17258766438 gnomAD-4.0.0 1.31413E-05 None None None None N None 4.82509E-05 0 None 0 0 None 0 0 0 0 0
T/I 9565 Ig-81 73 rs1423863240 0.455 -0.188 0.885 None 0.648 0.218 0.394837016283 gnomAD-2.1.1 6.37E-05 None None None None N None 2.29516E-04 0 None 0 0 None 0 None 0 0 0
T/I 9565 Ig-81 73 rs1423863240 0.455 -0.188 0.885 None 0.648 0.218 0.394837016283 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
T/I 9565 Ig-81 73 rs1423863240 0.455 -0.188 0.885 None 0.648 0.218 0.394837016283 gnomAD-4.0.0 3.71794E-06 None None None None N None 6.67307E-05 0 None 0 0 None 0 0 0 1.09784E-05 0
T/S 9565 Ig-81 73 rs368995369 0.2015 -1.283 0.969 None 0.57 0.227 None gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
T/S 9565 Ig-81 73 rs368995369 0.2015 -1.283 0.969 None 0.57 0.227 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
T/S 9565 Ig-81 73 rs368995369 0.2015 -1.283 0.969 None 0.57 0.227 None gnomAD-4.0.0 3.84266E-06 None None None None N None 5.07219E-05 0 None 0 0 None 0 0 0 0 0
V/A 9661 Ig-82 72 None 0.2998 None 0.472 None 0.567 0.142 0.406531046227 gnomAD-4.0.0 1.59124E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43295E-05 0
R/L 9770 Ig-83 73 None 0.8902 None 0.975 None 0.571 0.379 0.507093260865 gnomAD-4.0.0 6.84163E-07 None None None None I None 0 0 None 0 0 None 0 1.7337E-04 0 0 0
R/Q 9770 Ig-83 73 rs368309068 0.4792 -1.497 0.997 None 0.486 0.274 None gnomAD-2.1.1 5.22E-05 None None None None I None 1.29166E-04 0 None 0 0 None 0 None 0 9.74E-05 0
R/Q 9770 Ig-83 73 rs368309068 0.4792 -1.497 0.997 None 0.486 0.274 None gnomAD-3.1.2 6.57E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 1.02899E-04 2.07383E-04 0
R/Q 9770 Ig-83 73 rs368309068 0.4792 -1.497 0.997 None 0.486 0.274 None gnomAD-4.0.0 8.05513E-05 None None None None I None 6.66453E-05 0 None 0 0 None 0 0 9.40802E-05 3.29431E-05 1.76045E-04
R/P 9972 Ig-84 73 None 0.9991 None 0.999 None 0.737 0.422 0.361360026772 gnomAD-4.0.0 6.84408E-07 None None None None N None 2.98757E-05 0 None 0 0 None 0 0 0 0 0
R/Q 9972 Ig-84 73 rs752814410 0.9166 -1.226 0.999 None 0.611 0.333 0.223847106136 gnomAD-4.0.0 3.42205E-06 None None None None N None 0 0 None 0 2.51953E-05 None 0 1.7337E-04 2.6989E-06 0 0
S/L 10148 Ig-86 71 rs766069724 0.8176 -1.674 1.0 None 0.807 0.348 0.487983534966 gnomAD-2.1.1 3.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.23E-05 1.39978E-04
S/L 10148 Ig-86 71 rs766069724 0.8176 -1.674 1.0 None 0.807 0.348 0.487983534966 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
S/L 10148 Ig-86 71 rs766069724 0.8176 -1.674 1.0 None 0.807 0.348 0.487983534966 gnomAD-4.0.0 1.4252E-05 None None None None N None 0 0 None 0 6.68092E-05 None 0 0 1.61032E-05 0 1.60113E-05
T/A 13851 Ig-88 72 rs1346163990 0.2483 -1.347 0.552 N 0.551 0.205 0.218845423259 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
T/A 13851 Ig-88 72 rs1346163990 0.2483 -1.347 0.552 N 0.551 0.205 0.218845423259 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/A 13851 Ig-88 72 rs1346163990 0.2483 -1.347 0.552 N 0.551 0.205 0.218845423259 gnomAD-4.0.0 6.57514E-06 None None None None N None 2.41289E-05 0 None 0 0 None 0 0 0 0 0
T/P 13851 Ig-88 72 rs1346163990 0.9694 -0.798 0.977 N 0.713 0.273 0.312306559268 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
T/R 13851 Ig-88 72 rs1282841965 0.3834 -0.413 0.954 N 0.721 0.341 0.347659731818 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.92E-06 0
T/R 13851 Ig-88 72 rs1282841965 0.3834 -0.413 0.954 N 0.721 0.341 0.347659731818 gnomAD-4.0.0 3.18665E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86228E-06 1.43447E-05 0
A/T 13946 Ig-89 71 None 0.4645 None 0.028 N 0.37 0.085 0.0954503805726 gnomAD-4.0.0 6.88053E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.6645E-05
L/F 14035 Ig-90 71 rs1433887768 0.2711 -1.584 0.771 N 0.655 0.107 0.29385284311 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.89E-06 0
L/F 14035 Ig-90 71 rs1433887768 0.2711 -1.584 0.771 N 0.655 0.107 0.29385284311 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07469E-04 0
L/F 14035 Ig-90 71 rs1433887768 0.2711 -1.584 0.771 N 0.655 0.107 0.29385284311 gnomAD-4.0.0 8.05933E-06 None None None None N None 0 0 None 0 0 None 0 0 8.4786E-06 3.29583E-05 0
T/S 14123 Ig-91 70 None 0.1311 None 0.374 N 0.454 0.135 0.12205267543 gnomAD-4.0.0 1.5931E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86077E-06 0 0
V/L 14300 Ig-93 70 rs757079194 0.139 -0.128 0.004 N 0.459 0.034 0.115124310173 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
V/L 14300 Ig-93 70 rs757079194 0.139 -0.128 0.004 N 0.459 0.034 0.115124310173 gnomAD-4.0.0 1.59229E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85971E-06 0 0
S/P 14389 Ig-94 71 None 0.9503 None 0.996 N 0.755 0.249 0.295974979623 gnomAD-4.0.0 1.59255E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8608E-06 0 0
M/I 14478 Ig-95 71 rs1307051231 0.1261 -0.331 None D 0.222 0.214 0.117506650769 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93424E-04 None 0 0 0 0 0
M/I 14478 Ig-95 71 rs1307051231 0.1261 -0.331 None D 0.222 0.214 0.117506650769 gnomAD-4.0.0 6.57618E-06 None None None None N None 0 0 None 0 1.93424E-04 None 0 0 0 0 0
M/K 14478 Ig-95 71 rs1576690561 0.2169 None 0.055 N 0.539 0.359 0.714877521733 gnomAD-4.0.0 1.59218E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43336E-05 0
R/T 14567 Ig-96 71 rs555652524 0.1346 -1.722 0.117 N 0.533 0.301 None gnomAD-2.1.1 1.25E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.76E-05 0
R/T 14567 Ig-96 71 rs555652524 0.1346 -1.722 0.117 N 0.533 0.301 None gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 7.35E-05 0 0
R/T 14567 Ig-96 71 rs555652524 0.1346 -1.722 0.117 N 0.533 0.301 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
R/T 14567 Ig-96 71 rs555652524 0.1346 -1.722 0.117 N 0.533 0.301 None gnomAD-4.0.0 1.67814E-05 None None None None N None 0 0 None 0 0 None 0 0 2.29317E-05 0 0
T/I 14656 Ig-97 71 rs1001069675 0.1709 None 0.956 D 0.714 0.354 None gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
T/I 14656 Ig-97 71 rs1001069675 0.1709 None 0.956 D 0.714 0.354 None gnomAD-4.0.0 4.33927E-06 None None None None N None 8.01346E-05 0 None 0 0 None 0 0 0 0 1.60195E-05
T/N 14656 Ig-97 71 rs1001069675 0.2294 None 0.994 D 0.69 0.387 0.499154427049 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/N 14656 Ig-97 71 rs1001069675 0.2294 None 0.994 D 0.69 0.387 0.499154427049 gnomAD-4.0.0 6.57635E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47059E-05 0 0
Q/P 14834 Ig-99 70 None 0.8172 None 0.202 N 0.506 0.195 0.1749357433 gnomAD-4.0.0 6.86964E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01635E-07 0 0
T/S 14923 Ig-100 71 rs760857643 0.2661 -1.514 0.955 N 0.482 0.174 0.240491677333 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
T/S 14923 Ig-100 71 rs760857643 0.2661 -1.514 0.955 N 0.482 0.174 0.240491677333 gnomAD-4.0.0 1.36929E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79987E-06 0 0
N/H 15101 Ig-102 71 rs879050695 0.0946 None 0.009 N 0.432 0.314 None gnomAD-4.0.0 3.42364E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49981E-06 0 0
N/K 15101 Ig-102 71 None 0.5189 None 0.379 N 0.651 0.377 0.256793551483 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
N/S 15101 Ig-102 71 None 0.0712 None 0.016 N 0.242 0.229 0.143124449307 gnomAD-4.0.0 6.8472E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99947E-07 0 0
N/T 15101 Ig-102 71 None 0.1199 None 0.007 N 0.237 0.177 0.212008924253 gnomAD-4.0.0 6.8472E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99947E-07 0 0
V/A 15190 Ig-103 71 rs769206817 0.2515 -2.229 0.026 N 0.341 0.115 0.445410361449 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.93E-06 0
V/A 15190 Ig-103 71 rs769206817 0.2515 -2.229 0.026 N 0.341 0.115 0.445410361449 gnomAD-4.0.0 3.42326E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69936E-06 2.32002E-05 0
V/I 15190 Ig-103 71 rs776996868 0.0911 -0.51 0.98 N 0.648 0.083 0.317958651998 gnomAD-2.1.1 3.23E-05 None None None None N None 0 0 None 0 0 None 1.63538E-04 None 0 2.68E-05 0
V/I 15190 Ig-103 71 rs776996868 0.0911 -0.51 0.98 N 0.648 0.083 0.317958651998 gnomAD-4.0.0 1.30086E-05 None None None None N None 2.99365E-05 0 None 0 0 None 0 0 2.6994E-06 1.74006E-04 0
I/L 15372 Ig-105 71 None 0.1382 None 0.005 N 0.427 0.043 0.290590437066 gnomAD-4.0.0 6.8481E-07 None None None None N None 0 0 None 3.83759E-05 0 None 0 0 0 0 0
I/T 15372 Ig-105 71 None 0.0629 None None N 0.329 0.162 0.376745185316 gnomAD-4.0.0 1.59452E-06 None None None None N None 0 2.29074E-05 None 0 0 None 0 0 0 0 0
I/V 15372 Ig-105 71 rs2154211008 0.0729 None None N 0.171 0.04 0.225215365344 gnomAD-4.0.0 6.8481E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00077E-07 0 0
R/I 15550 Ig-107 71 rs1229831088 0.4173 -0.463 0.999 D 0.753 0.528 0.771231716895 gnomAD-2.1.1 4.04E-06 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 0 0
R/I 15550 Ig-107 71 rs1229831088 0.4173 -0.463 0.999 D 0.753 0.528 0.771231716895 gnomAD-4.0.0 6.84868E-07 None None None None N None 2.99742E-05 0 None 0 0 None 0 0 0 0 0
R/T 15550 Ig-107 71 None 0.4808 None 0.998 N 0.638 0.504 0.623027447215 gnomAD-4.0.0 6.84868E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00132E-07 0 0
T/I 16034 Ig-109 67 rs1247903486 0.1716 0.287 0.82 D 0.621 0.196 0.365509141856 gnomAD-2.1.1 7.67E-05 None None None None N None 0 5.51332E-04 None 0 0 None 0 None 0 0 0
T/I 16034 Ig-109 67 rs1247903486 0.1716 0.287 0.82 D 0.621 0.196 0.365509141856 gnomAD-3.1.2 1.90938E-04 None None None None N None 0 1.90489E-03 0 0 0 None 0 0 0 0 0
T/I 16034 Ig-109 67 rs1247903486 0.1716 0.287 0.82 D 0.621 0.196 0.365509141856 gnomAD-4.0.0 6.02951E-05 None None None None N None 0 7.97611E-04 None 0 0 None 0 0 0 0 0
T/K 16034 Ig-109 67 None 0.2062 None 0.722 N 0.595 0.253 0.346768085243 gnomAD-4.0.0 1.59333E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86223E-06 0 0
M/I 17348 Ig-112 98 rs758852311 0.2782 -0.822 0.015 N 0.411 0.107 0.389750110748 gnomAD-2.1.1 4.92E-06 None None None None I None 0 0 None 0 0 None 5.13E-05 None 0 0 0
M/I 17348 Ig-112 98 rs758852311 0.2782 -0.822 0.015 N 0.411 0.107 0.389750110748 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 0 4.14422E-04 0
M/I 17348 Ig-112 98 rs758852311 0.2782 -0.822 0.015 N 0.411 0.107 0.389750110748 gnomAD-4.0.0 7.05167E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.37914E-04 0
M/T 17348 Ig-112 98 rs992739626 0.1219 -1.509 None N 0.249 0.184 0.365703291355 gnomAD-2.1.1 4.88E-06 None None None None I None 0 3.6E-05 None 0 0 None 0 None 0 0 0
M/T 17348 Ig-112 98 rs992739626 0.1219 -1.509 None N 0.249 0.184 0.365703291355 gnomAD-4.0.0 4.25587E-06 None None None None I None 0 2.7027E-05 None 0 0 None 0 0 4.58874E-06 0 0
M/V 17348 Ig-112 98 rs780570190 0.0984 -1.189 None N 0.141 0.221 None gnomAD-2.1.1 1.89E-05 None None None None I None 0 0 None 0 2.38464E-04 None 0 None 0 0 0
M/V 17348 Ig-112 98 rs780570190 0.0984 -1.189 None N 0.141 0.221 None gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.94553E-04 None 0 0 0 0 0
M/V 17348 Ig-112 98 rs780570190 0.0984 -1.189 None N 0.141 0.221 None gnomAD-4.0.0 1.78335E-05 None None None None I None 0 0 None 0 6.09481E-04 None 0 0 8.61741E-07 0 0
V/L 17743 Ig-113 67 None 0.3377 None None N 0.149 0.038 0.0762999501168 gnomAD-4.0.0 6.84428E-07 None None None None N None 2.99097E-05 0 None 0 0 None 0 0 0 0 0
V/M 17743 Ig-113 67 None 0.2303 None 0.019 N 0.341 0.042 0.0806252709748 gnomAD-4.0.0 1.36886E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79942E-06 0 0
T/A 18044 Ig-114 77 rs397517616 0.1507 None 0.999 N 0.552 0.402 0.240491677333 gnomAD-4.0.0 1.59573E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86666E-06 0 0
T/I 18044 Ig-114 77 rs1434797561 0.2349 0.155 1.0 N 0.771 0.438 0.416328079214 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
T/I 18044 Ig-114 77 rs1434797561 0.2349 0.155 1.0 N 0.771 0.438 0.416328079214 gnomAD-4.0.0 2.74026E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.48545E-05 1.65893E-05
T/P 18044 Ig-114 77 rs397517616 0.9244 -0.603 1.0 N 0.773 0.508 0.50466331119 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
T/P 18044 Ig-114 77 rs397517616 0.9244 -0.603 1.0 N 0.773 0.508 0.50466331119 gnomAD-4.0.0 3.19145E-06 None None None None N None 0 4.58106E-05 None 0 0 None 0 0 0 0 0
S/G 18458 Ig-115 77 rs368890202 0.1731 -0.736 0.98 N 0.517 0.152 None gnomAD-2.1.1 4.07E-06 None None None None N None 6.49E-05 0 None 0 0 None 0 None 0 0 0
S/R 18458 Ig-115 77 rs200550947 0.6694 -0.23 0.994 N 0.636 0.37 0.298056030225 gnomAD-2.1.1 4.11537E-04 None None None None N None 1.65865E-04 5.74E-05 None 0 0 None 3.36E-05 None 6.44019E-04 7.0103E-04 2.8401E-04
S/R 18458 Ig-115 77 rs200550947 0.6694 -0.23 0.994 N 0.636 0.37 0.298056030225 gnomAD-3.1.2 6.05096E-04 None None None None N None 1.92985E-04 0 0 0 0 None 4.70987E-04 0 1.16224E-03 0 0
S/R 18458 Ig-115 77 rs200550947 0.6694 -0.23 0.994 N 0.636 0.37 0.298056030225 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
S/R 18458 Ig-115 77 rs200550947 0.6694 -0.23 0.994 N 0.636 0.37 0.298056030225 gnomAD-4.0.0 6.4023E-04 None None None None N None 1.4702E-04 3.36089E-05 None 0 0 None 7.52045E-04 0 7.90676E-04 1.11037E-05 5.93805E-04
T/I 18763 Ig-116 76 rs746218913 0.2529 -0.168 0.317 N 0.713 0.112 0.186928172975 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/I 18763 Ig-116 76 rs746218913 0.2529 -0.168 0.317 N 0.713 0.112 0.186928172975 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
T/I 18763 Ig-116 76 rs746218913 0.2529 -0.168 0.317 N 0.713 0.112 0.186928172975 gnomAD-4.0.0 1.18051E-05 None None None None N None 1.33915E-05 0 None 0 0 None 0 0 1.44355E-05 0 1.6055E-05
T/N 18763 Ig-116 76 rs746218913 0.2751 -1.201 0.062 N 0.633 0.208 0.167679373172 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 3.34E-05 None 0 0 0
T/N 18763 Ig-116 76 rs746218913 0.2751 -1.201 0.062 N 0.633 0.208 0.167679373172 gnomAD-4.0.0 2.05834E-06 None None None None N None 3.00499E-05 0 None 0 0 None 0 0 0 2.34285E-05 0
S/C 19162 Ig-117 68 rs751697133 0.0936 -0.208 0.97 N 0.562 0.348 0.350964488264 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/C 19162 Ig-117 68 rs751697133 0.0936 -0.208 0.97 N 0.562 0.348 0.350964488264 gnomAD-4.0.0 1.59286E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43308E-05 0
C/R 19458 Ig-118 68 rs867494706 0.2465 None 0.001 N 0.607 0.208 0.448597761117 gnomAD-4.0.0 1.59171E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85909E-06 0 0
C/W 19458 Ig-118 68 rs777855018 0.3742 None 0.828 N 0.635 0.19 0.514923749907 gnomAD-4.0.0 1.59172E-06 None None None None N None 0 0 None 0 0 None 1.88232E-05 0 0 0 0
S/F 19856 Ig-119 67 None 0.2562 None 0.998 N 0.762 0.495 0.537034694273 gnomAD-4.0.0 1.59196E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43332E-05 0
S/Y 19856 Ig-119 67 rs1356252369 0.2223 -0.839 0.998 N 0.759 0.426 0.50143340055 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
S/Y 19856 Ig-119 67 rs1356252369 0.2223 -0.839 0.998 N 0.759 0.426 0.50143340055 gnomAD-4.0.0 1.59196E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85946E-06 0 0
I/T 20548 Ig-121 70 None 0.1762 None 0.022 N 0.339 0.147 0.378322506985 gnomAD-4.0.0 1.36887E-06 None None None None N None 0 0 None 0 2.52564E-05 None 0 0 0 0 1.65706E-05
I/V 20548 Ig-121 70 None 0.079 None 0.022 N 0.185 0.041 0.315609569513 gnomAD-4.0.0 1.59248E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86028E-06 0 0
S/G 21538 Ig-124 70 rs1297730026 0.127 None 0.124 N 0.614 0.136 0.239901079897 gnomAD-4.0.0 4.7781E-06 None None None None N None 0 0 None 0 8.3227E-05 None 0 0 0 0 0
T/A 21935 Ig-125 70 rs1340276785 0.1186 -1.356 0.863 N 0.586 0.266 0.180583059064 gnomAD-2.1.1 4.14E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.08E-06 0
T/A 21935 Ig-125 70 rs1340276785 0.1186 -1.356 0.863 N 0.586 0.266 0.180583059064 gnomAD-4.0.0 1.65038E-06 None None None None N None 0 0 None 0 0 None 0 0 2.96648E-06 0 0
T/I 21935 Ig-125 70 rs571121441 0.1423 0.028 0.885 N 0.578 0.246 0.342865806769 gnomAD-2.1.1 8.3E-06 None None None None N None 0 6.1E-05 None 0 0 None 0 None 0 0 0
T/I 21935 Ig-125 70 rs571121441 0.1423 0.028 0.885 N 0.578 0.246 0.342865806769 gnomAD-3.1.2 1.97E-05 None None None None N None 0 1.96644E-04 0 0 0 None 0 0 0 0 0
T/I 21935 Ig-125 70 rs571121441 0.1423 0.028 0.885 N 0.578 0.246 0.342865806769 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
T/I 21935 Ig-125 70 rs571121441 0.1423 0.028 0.885 N 0.578 0.246 0.342865806769 gnomAD-4.0.0 1.13241E-05 None None None None N None 0 2.23675E-04 None 0 0 None 0 0 2.57269E-06 2.31766E-05 0
T/N 21935 Ig-125 70 rs571121441 0.2243 None 0.997 N 0.593 0.311 0.353974658523 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.43E-05 0 0 0 0
T/N 21935 Ig-125 70 rs571121441 0.2243 None 0.997 N 0.593 0.311 0.353974658523 gnomAD-4.0.0 1.25833E-06 None None None None N None 0 0 None 0 0 None 1.5749E-05 0 8.57556E-07 0 0
I/T 22333 Ig-126 69 rs2154176318 0.1465 None 0.379 N 0.468 0.271 0.385417323374 gnomAD-4.0.0 1.59245E-06 None None None None N None 0 2.28676E-05 None 0 0 None 0 0 0 0 0
I/V 22333 Ig-126 69 rs753147042 0.0759 -1.398 0.001 N 0.123 0.047 0.307332253619 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/V 22333 Ig-126 69 rs753147042 0.0759 -1.398 0.001 N 0.123 0.047 0.307332253619 gnomAD-4.0.0 1.59244E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43332E-05 0
T/A 22622 Ig-127 63 None 0.0891 None 0.989 N 0.507 0.362 0.303123707472 gnomAD-4.0.0 3.18415E-06 None None None None N None 5.66316E-05 0 None 0 0 None 0 0 2.85995E-06 0 0
T/I 23019 Ig-128 70 None 0.1448 None 0.125 N 0.448 0.146 0.339555952218 gnomAD-4.0.0 3.1848E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71971E-06 0 0
V/F 23414 Ig-129 70 rs759158138 0.1861 -1.226 0.772 N 0.545 0.196 0.515430650102 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.66E-05 0
V/F 23414 Ig-129 70 rs759158138 0.1861 -1.226 0.772 N 0.545 0.196 0.515430650102 gnomAD-4.0.0 4.77493E-06 None None None None N None 0 0 None 0 0 None 0 0 8.578E-06 0 0
P/L 23705 Ig-130 69 rs765591920 0.1013 0.244 0.521 N 0.586 0.286 0.350307294319 gnomAD-2.1.1 8.05E-06 None None None None N None 0 5.81E-05 None 0 0 None 0 None 0 0 0
P/L 23705 Ig-130 69 rs765591920 0.1013 0.244 0.521 N 0.586 0.286 0.350307294319 gnomAD-4.0.0 4.77625E-06 None None None None N None 0 4.57477E-05 None 0 0 None 0 0 0 0 3.0259E-05
P/T 23705 Ig-130 69 None 0.0917 None 0.028 N 0.251 0.19 0.12205267543 gnomAD-4.0.0 1.36872E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79916E-06 0 0
T/I 24101 Ig-131 73 rs192962624 0.0604 0.032 0.002 N 0.485 0.045 0.151104730317 gnomAD-2.1.1 2.82E-05 None None None None N None 0 0 None 0 0 None 2.29373E-04 None 0 0 0
T/I 24101 Ig-131 73 rs192962624 0.0604 0.032 0.002 N 0.485 0.045 0.151104730317 gnomAD-4.0.0 1.23266E-05 None None None None N None 0 0 None 0 0 None 0 1.73671E-04 9.00148E-07 1.85766E-04 0
T/N 24101 Ig-131 73 None 0.1443 -0.688 0.002 N 0.477 0.156 None gnomAD-2.1.1 3.64752E-04 None None None None N None 0 2.84E-05 None 0 4.37783E-03 None 4.91513E-04 None 0 0 1.41163E-04
T/N 24101 Ig-131 73 None 0.1443 -0.688 0.002 N 0.477 0.156 None gnomAD-3.1.2 1.84135E-04 None None None None N None 2.41E-05 6.56E-05 0 0 3.67932E-03 None 0 0 0 1.45048E-03 0
T/N 24101 Ig-131 73 None 0.1443 -0.688 0.002 N 0.477 0.156 None 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 2E-03 0 None None None 0 None
T/N 24101 Ig-131 73 None 0.1443 -0.688 0.002 N 0.477 0.156 None gnomAD-4.0.0 1.383E-04 None None None None N None 2.66731E-05 3.33734E-05 None 0 3.0173E-03 None 0 0 0 6.15709E-04 4.48545E-04
I/T 24498 Ig-132 68 rs999356680 0.1117 -1.605 0.324 N 0.483 0.23 0.444305618086 gnomAD-2.1.1 8.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 1.665E-04
I/T 24498 Ig-132 68 rs999356680 0.1117 -1.605 0.324 N 0.483 0.23 0.444305618086 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 24498 Ig-132 68 rs999356680 0.1117 -1.605 0.324 N 0.483 0.23 0.444305618086 gnomAD-4.0.0 3.71943E-06 None None None None I None 0 0 None 0 0 None 0 0 1.69562E-06 3.29533E-05 1.60185E-05
I/V 24498 Ig-132 68 None 0.0613 None 0.041 N 0.311 0.074 0.286848849266 gnomAD-4.0.0 1.59265E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43394E-05 0
V/E 24787 Ig-133 72 None 0.1351 None 0.055 N 0.539 0.116 0.261217442401 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
I/K 25183 Ig-134 73 None 0.1934 None 0.175 N 0.577 0.176 0.449764926163 gnomAD-4.0.0 1.02655E-05 None None None None N None 0 0 None 0 0 None 1.8735E-05 0 1.16945E-05 0 1.65728E-05
I/V 25183 Ig-134 73 rs1180372550 0.0604 None None N 0.17 0.053 0.180583059064 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 3.16456E-03 0 0 0
I/V 25183 Ig-134 73 rs1180372550 0.0604 None None N 0.17 0.053 0.180583059064 gnomAD-4.0.0 2.56343E-06 None None None None N None 0 0 None 0 0 None 0 4.48833E-04 0 0 0
T/A 25580 Ig-135 67 rs371711135 0.1103 -1.426 0.892 N 0.478 0.248 None gnomAD-2.1.1 2.15E-05 None None None None N None 8.27E-05 0 None 0 2.05719E-04 None 0 None 0 0 0
T/A 25580 Ig-135 67 rs371711135 0.1103 -1.426 0.892 N 0.478 0.248 None gnomAD-3.1.2 9.86E-05 None None None None N None 1.93097E-04 6.56E-05 0 0 7.73395E-04 None 0 0 0 0 9.56023E-04
T/A 25580 Ig-135 67 rs371711135 0.1103 -1.426 0.892 N 0.478 0.248 None gnomAD-4.0.0 1.6736E-05 None None None None N None 2.00342E-04 1.66822E-05 None 0 1.33875E-04 None 0 0 0 0 8.00769E-05
T/K 25580 Ig-135 67 rs56372592 0.3097 -0.29 0.993 N 0.644 0.324 None gnomAD-2.1.1 2.11159E-04 None None None None N None 1.24131E-04 8.5E-05 None 0 0 None 0 None 4E-05 3.84259E-04 4.21941E-04
T/K 25580 Ig-135 67 rs56372592 0.3097 -0.29 0.993 N 0.644 0.324 None gnomAD-3.1.2 2.36774E-04 None None None None N None 9.66E-05 6.57E-05 0 0 0 None 0 0 4.26496E-04 0 9.56938E-04
T/K 25580 Ig-135 67 rs56372592 0.3097 -0.29 0.993 N 0.644 0.324 None gnomAD-4.0.0 6.51499E-04 None None None None N None 8.01518E-05 1.5018E-04 None 3.38021E-05 0 None 3.1252E-05 0 8.49471E-04 0 4.96524E-04
T/M 25580 Ig-135 67 rs56372592 0.0772 -0.241 0.998 N 0.664 0.36 None gnomAD-2.1.1 1.61769E-03 None None None None N None 6.62032E-04 1.41659E-04 None 0 2.0426E-02 None 2.28953E-04 None 0 1.56841E-04 9.84529E-04
T/M 25580 Ig-135 67 rs56372592 0.0772 -0.241 0.998 N 0.664 0.36 None gnomAD-3.1.2 9.3394E-04 None None None None N None 5.31144E-04 4.59559E-04 0 0 1.95433E-02 None 0 0 8.82E-05 2.06782E-04 2.39234E-03
T/M 25580 Ig-135 67 rs56372592 0.0772 -0.241 0.998 N 0.664 0.36 None 1000 genomes 4.59265E-03 None None None None N None 0 0 None None 2.28E-02 0 None None None 0 None
T/M 25580 Ig-135 67 rs56372592 0.0772 -0.241 0.998 N 0.664 0.36 None gnomAD-4.0.0 5.79551E-04 None None None None N None 5.06802E-04 3.16941E-04 None 0 1.28566E-02 None 0 0 8.47781E-05 2.85589E-04 2.81807E-03
T/R 25580 Ig-135 67 None 0.2408 None 0.998 N 0.649 0.335 0.370789594751 gnomAD-4.0.0 6.84389E-07 None None None None N None 0 0 None 0 2.52232E-05 None 0 0 0 0 0
G/R 25869 Ig-136 72 None 0.1732 None 0.491 N 0.687 0.128 0.401185642668 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
I/F 26265 Ig-137 73 None 0.1888 None 0.884 N 0.481 0.227 0.390220360785 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
I/T 26662 Ig-138 69 None 0.1901 None None N 0.359 0.058 0.176091768786 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 6.17284E-04 0 0 0
T/I 26951 Ig-139 72 None 0.1128 None 0.055 N 0.601 0.07 0.198526703765 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
T/N 26951 Ig-139 72 None 0.1434 None 0.029 N 0.464 0.147 0.209622950755 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/S 27745 Ig-141 70 None 0.0926 None 0.028 N 0.172 0.092 0.0611884634855 gnomAD-4.0.0 1.59207E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02737E-05
E/K 28034 Ig-142 72 rs1243085385 0.203 None 0.998 N 0.446 0.343 0.240491677333 gnomAD-4.0.0 6.84403E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99562E-07 0 0
E/V 28034 Ig-142 72 None 0.21 None 0.733 N 0.49 0.209 0.324161360171 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
V/E 28429 Ig-143 72 rs747216991 0.3355 -1.229 0.124 N 0.638 0.278 0.534093007224 gnomAD-2.1.1 8.05E-06 None None None None I None 0 5.81E-05 None 0 0 None 0 None 0 0 0
V/E 28429 Ig-143 72 rs747216991 0.3355 -1.229 0.124 N 0.638 0.278 0.534093007224 gnomAD-3.1.2 1.31E-05 None None None None I None 0 1.30993E-04 0 0 0 None 0 0 0 0 0
V/E 28429 Ig-143 72 rs747216991 0.3355 -1.229 0.124 N 0.638 0.278 0.534093007224 gnomAD-4.0.0 7.68748E-06 None None None None I None 0 1.01716E-04 None 0 0 None 0 0 0 0 0
T/I 28824 Ig-144 70 rs200709344 0.1009 -0.304 1.0 N 0.828 0.407 None gnomAD-2.1.1 1.03915E-04 None None None None N None 0 2.27092E-04 None 0 0 None 0 None 0 1.56755E-04 1.41163E-04
T/I 28824 Ig-144 70 rs200709344 0.1009 -0.304 1.0 N 0.828 0.407 None gnomAD-3.1.2 9.86E-05 None None None None N None 0 6.55E-05 1.09649E-03 0 0 None 0 0 1.9107E-04 0 0
T/I 28824 Ig-144 70 rs200709344 0.1009 -0.304 1.0 N 0.828 0.407 None gnomAD-4.0.0 1.24603E-04 None None None None N None 0 1.16791E-04 None 0 0 None 0 0 1.54299E-04 0 1.76163E-04
T/S 28824 Ig-144 70 None 0.1211 None 0.999 N 0.503 0.249 0.242825505644 gnomAD-4.0.0 1.59337E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43715E-05 0
E/G 29116 Ig-145 72 None 0.2418 None 0.896 N 0.558 0.279 0.276482976112 gnomAD-4.0.0 6.84218E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65645E-05
E/K 29116 Ig-145 72 rs1472877475 0.2551 -0.663 0.896 N 0.476 0.192 0.191931220699 gnomAD-2.1.1 3.18E-05 None None None None N None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
I/S 29911 Ig-147 70 rs1261129308 0.1965 None 0.175 N 0.515 0.151 0.587387877561 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/S 29911 Ig-147 70 rs1261129308 0.1965 None 0.175 N 0.515 0.151 0.587387877561 gnomAD-4.0.0 6.56901E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46977E-05 0 0
T/S 30203 Ig-148 72 None 0.1387 None 0.716 N 0.451 0.108 0.173771789658 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/S 30203 Ig-148 72 None 0.1387 None 0.716 N 0.451 0.108 0.173771789658 gnomAD-4.0.0 4.791E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29723E-06 0 0
T/K 30598 Ig-149 67 None 0.169 None None N 0.424 0.205 0.244539031024 gnomAD-4.0.0 6.84254E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15966E-05 0
T/R 30598 Ig-149 67 rs370342796 0.1175 None None N 0.349 0.092 None gnomAD-4.0.0 3.42127E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49758E-06 0 0
T/N 30995 Ig-150 69 rs886042408 0.1856 -0.954 0.995 N 0.573 0.332 0.346085882481 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
T/N 30995 Ig-150 69 rs886042408 0.1856 -0.954 0.995 N 0.573 0.332 0.346085882481 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
T/N 30995 Ig-150 69 rs886042408 0.1856 -0.954 0.995 N 0.573 0.332 0.346085882481 gnomAD-4.0.0 8.96709E-06 None None None None N None 0 0 None 0 0 None 0 0 1.67505E-05 0 0
F/S 31287 Ig-151 70 rs374887049 0.2385 -2.174 0.324 N 0.559 0.219 None gnomAD-2.1.1 2.5E-05 None None None None N None 2.89376E-04 0 None 0 0 None 0 None 0 0 0
F/S 31287 Ig-151 70 rs374887049 0.2385 -2.174 0.324 N 0.559 0.219 None gnomAD-3.1.2 5.26E-05 None None None None N None 1.93069E-04 0 0 0 0 None 0 0 0 0 0
F/S 31287 Ig-151 70 rs374887049 0.2385 -2.174 0.324 N 0.559 0.219 None gnomAD-4.0.0 1.05343E-05 None None None None N None 2.26957E-04 0 None 0 0 None 0 0 0 0 0
T/I 31687 Ig-152 67 rs1471246687 0.1073 -0.183 0.061 N 0.275 0.192 0.286848849266 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/I 31687 Ig-152 67 rs1471246687 0.1073 -0.183 0.061 N 0.275 0.192 0.286848849266 gnomAD-4.0.0 2.73694E-06 None None None None N None 0 2.23614E-05 None 0 0 None 0 0 2.69854E-06 0 0
T/A 32084 Ig-153 68 None 0.1062 None 0.201 N 0.455 0.224 0.141422826196 gnomAD-4.0.0 1.36848E-06 None None Phosphothreonine None N None 0 0 None 0 0 None 0 0 1.79902E-06 0 0
T/I 32084 Ig-153 68 None 0.095 None 0.004 N 0.288 0.18 0.253205268125 gnomAD-4.0.0 3.60097E-06 None None Phosphothreonine None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
T/I 32378 Ig-154 72 None 0.1008 None None N 0.412 0.094 0.202086224978 gnomAD-4.0.0 1.59126E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85832E-06 0 0
T/P 32378 Ig-154 72 None 0.6012 None 0.741 N 0.556 0.237 0.380901646489 gnomAD-4.0.0 1.59125E-06 None None None None N None 0 0 None 0 2.77285E-05 None 0 0 0 0 0
D/E 32774 Ig-155 67 rs767435784 0.4499 -0.555 1.0 N 0.477 0.173 0.183819452728 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/E 32774 Ig-155 67 rs767435784 0.4499 -0.555 1.0 N 0.477 0.173 0.183819452728 gnomAD-4.0.0 1.5912E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02352E-05
D/V 32774 Ig-155 67 None 0.5446 None 1.0 N 0.874 0.378 0.369495900351 gnomAD-4.0.0 1.59119E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85819E-06 0 0
T/I 33172 Ig-156 72 None 0.3188 None 1.0 N 0.766 0.449 0.519837540645 gnomAD-4.0.0 6.84231E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99473E-07 0 0
T/S 33172 Ig-156 72 None 0.1576 None 0.998 N 0.569 0.371 0.247322355667 gnomAD-4.0.0 6.84231E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99473E-07 0 0
K/R 33269 Ig-157 67 None 0.0986 None 0.192 N 0.375 0.095 0.101711395817 gnomAD-4.0.0 1.60617E-06 None None None None N None 0 0 None 0 0 None 0 0 2.89256E-06 0 0
Q/H 33569 Ig-158 74 rs1289268364 0.7253 -1.436 1.0 N 0.707 0.401 0.442054744378 gnomAD-2.1.1 8.6E-06 None None None None N None 0 0 None 0 0 None 7.61E-05 None 0 0 0
Q/H 33569 Ig-158 74 rs1289268364 0.7253 -1.436 1.0 N 0.707 0.401 0.442054744378 gnomAD-4.0.0 3.31873E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.05857E-05 0
V/A 33668 Ig-159 73 rs372534712 0.6027 None 0.936 N 0.538 0.262 None gnomAD-4.0.0 4.78951E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29628E-06 0 0
V/E 33668 Ig-159 73 None 0.8182 None 0.99 N 0.595 0.445 0.578293158758 gnomAD-4.0.0 6.84215E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99468E-07 0 0
V/M 33668 Ig-159 73 rs1417934977 0.2796 -0.739 0.994 N 0.529 0.184 0.241078983079 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
V/M 33668 Ig-159 73 rs1417934977 0.2796 -0.739 0.994 N 0.529 0.184 0.241078983079 gnomAD-4.0.0 1.59129E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8583E-06 0 0
T/A 34332 Ig-161 75 rs1450806366 0.1059 -1.379 None N 0.291 0.123 0.0482279557977 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 0 9.2081E-04
T/A 34332 Ig-161 75 rs1450806366 0.1059 -1.379 None N 0.291 0.123 0.0482279557977 gnomAD-3.1.2 2.63E-05 None None None None N None 0 6.54E-05 0 0 0 None 0 0 0 0 1.43678E-03
T/A 34332 Ig-161 75 rs1450806366 0.1059 -1.379 None N 0.291 0.123 0.0482279557977 gnomAD-4.0.0 5.07448E-06 None None None None N None 0 6.14704E-05 None 0 0 None 0 0 0 0 1.36119E-04
R/K 34435 Ig-162 73 rs1309913813 0.2411 -1.639 0.219 N 0.269 0.152 0.235038932564 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
R/K 34435 Ig-162 73 rs1309913813 0.2411 -1.639 0.219 N 0.269 0.152 0.235038932564 gnomAD-4.0.0 1.59105E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85768E-06 0 0
R/T 34435 Ig-162 73 None 0.7125 None 0.99 N 0.455 0.283 0.574843327095 gnomAD-4.0.0 1.59105E-06 None None None None N None 0 0 None 0 0 None 0 2.4108E-04 0 0 0
R/C 35013 Ig-163 72 rs568460311 0.6668 -1.613 1.0 N 0.816 0.368 None gnomAD-2.1.1 9.27E-05 None None None None N None 2.06714E-04 2.83E-05 None 0 4.10256E-04 None 0 None 8E-05 7.8E-05 0
R/C 35013 Ig-163 72 rs568460311 0.6668 -1.613 1.0 N 0.816 0.368 None gnomAD-3.1.2 9.2E-05 None None None None N None 1.69033E-04 6.54E-05 0 0 3.85356E-04 None 0 0 2.94E-05 0 9.57854E-04
R/C 35013 Ig-163 72 rs568460311 0.6668 -1.613 1.0 N 0.816 0.368 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
R/C 35013 Ig-163 72 rs568460311 0.6668 -1.613 1.0 N 0.816 0.368 None gnomAD-4.0.0 3.65566E-05 None None None None N None 1.86637E-04 3.33189E-05 None 0 2.22876E-04 None 9.37266E-05 0 1.61035E-05 0 1.28033E-04
R/H 35013 Ig-163 72 rs779484675 0.3493 -1.995 1.0 N 0.751 0.421 None gnomAD-2.1.1 3.21E-05 None None None None N None 0 0 None 0 0 None 1.96066E-04 None 0 1.77E-05 0
R/H 35013 Ig-163 72 rs779484675 0.3493 -1.995 1.0 N 0.751 0.421 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 6.54E-05 0 0 0 None 0 0 1.47E-05 0 0
R/H 35013 Ig-163 72 rs779484675 0.3493 -1.995 1.0 N 0.751 0.421 None gnomAD-4.0.0 2.85035E-05 None None None None N None 1.33518E-05 1.6665E-05 None 0 0 None 1.5623E-05 0 2.11883E-05 1.97624E-04 0
R/P 35013 Ig-163 72 None 0.9982 None 1.0 N 0.781 0.527 0.41441075005 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92604E-04 None 0 0 0 0 0
R/P 35013 Ig-163 72 None 0.9982 None 1.0 N 0.781 0.527 0.41441075005 gnomAD-4.0.0 6.57237E-06 None None None None N None 0 0 None 0 1.92604E-04 None 0 0 0 0 0
R/S 35013 Ig-163 72 rs568460311 0.9523 -2.031 1.0 N 0.743 0.429 0.262662153117 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/S 35013 Ig-163 72 rs568460311 0.9523 -2.031 1.0 N 0.743 0.429 0.262662153117 gnomAD-4.0.0 1.3683E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31868E-05 0
S/G 35200 Ig-164 72 None 0.1524 None 0.009 N 0.511 0.089 0.154104182512 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/T 35200 Ig-164 72 None 0.0642 None None N 0.191 0.062 0.0611884634855 gnomAD-4.0.0 1.59094E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85747E-06 0 0
V/D 35358 Ig-165 73 rs1172243981 0.4144 None 0.055 N 0.689 0.224 0.563099480232 gnomAD-4.0.0 6.84142E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99395E-07 0 0
V/G 35358 Ig-165 73 rs1172243981 0.286 -2.985 0.055 N 0.686 0.184 0.549755530797 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.56E-05 None 0 None 0 0 0
V/G 35358 Ig-165 73 rs1172243981 0.286 -2.985 0.055 N 0.686 0.184 0.549755530797 gnomAD-4.0.0 6.84142E-07 None None None None N None 0 0 None 0 2.51902E-05 None 0 0 0 0 0
T/I 35491 Ig-166 72 rs1461069852 0.1458 -0.42 0.005 N 0.461 0.027 0.132336055621 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
T/I 35491 Ig-166 72 rs1461069852 0.1458 -0.42 0.005 N 0.461 0.027 0.132336055621 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 35491 Ig-166 72 rs1461069852 0.1458 -0.42 0.005 N 0.461 0.027 0.132336055621 gnomAD-4.0.0 6.57091E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46998E-05 0 0
T/N 35491 Ig-166 72 rs1461069852 0.1431 None None N 0.217 0.077 0.128392430309 gnomAD-4.0.0 1.60283E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86615E-06 0 0
T/I 35676 Ig-167 70 rs764714213 0.3409 0.399 0.497 N 0.722 0.199 0.320256813643 gnomAD-2.1.1 1.61E-05 None None None None N None 0 1.16394E-04 None 0 0 None 0 None 0 0 0
T/I 35676 Ig-167 70 rs764714213 0.3409 0.399 0.497 N 0.722 0.199 0.320256813643 gnomAD-4.0.0 6.36772E-06 None None None None N None 0 9.15499E-05 None 0 0 None 0 0 0 0 0
T/K 35773 Ig-168 72 None 0.5422 None 1.0 N 0.819 0.371 None gnomAD-4.0.0 3.1821E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71562E-06 0 0
T/I 35970 Ig-169 74 rs765869850 0.2581 None 0.999 N 0.765 0.378 0.433713641954 gnomAD-4.0.0 2.0525E-06 None None None -1.097(OBSL1) -0.06(OBSCN) N None 0 0 None 0 0 None 0 0 2.69823E-06 0 0
T/N 35970 Ig-169 74 None 0.2459 -0.791 0.999 N 0.656 0.385 0.405979908929 gnomAD-2.1.1 8.03E-06 None None None -0.763(OBSL1) -0.257(OBSCN) N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
T/N 35970 Ig-169 74 None 0.2459 -0.791 0.999 N 0.656 0.385 0.405979908929 gnomAD-4.0.0 2.0525E-06 None None None -0.763(OBSL1) -0.257(OBSCN) N None 0 0 None 0 2.51927E-05 None 0 0 0 2.319E-05 0
T/S 35970 Ig-169 74 rs765869850 0.162 -1.237 0.905 N 0.393 0.272 0.177238962908 gnomAD-2.1.1 4.02E-06 None None None -0.901(OBSL1) -0.039(OBSCN) N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
T/S 35970 Ig-169 74 rs765869850 0.162 -1.237 0.905 N 0.393 0.272 0.177238962908 gnomAD-4.0.0 6.84166E-07 None None None -0.901(OBSL1) -0.039(OBSCN) N None 0 0 None 0 0 None 0 0 8.9941E-07 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.