Structural position:

  • Domain Type: Ig
  • Aligned Position: 162
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
G/E 85 Ig-1 80 rs758092470 0.3117 -0.351 1.0 N 0.679 0.468 0.442261297928 gnomAD-2.1.1 3.98E-06 None None None 0.476(TCAP) I None 0 0 None 0 0 None 0 None 4.62E-05 0 0
G/E 85 Ig-1 80 rs758092470 0.3117 -0.351 1.0 N 0.679 0.468 0.442261297928 gnomAD-4.0.0 1.59047E-06 None None None 0.476(TCAP) I None 0 0 None 0 0 None 1.88168E-05 0 0 0 0
S/N 181 Ig-2 78 rs72647843 0.192 -0.089 0.002 D 0.296 0.157 None gnomAD-2.1.1 5.7996E-03 None None None -0.285(TCAP) I None 5.80035E-02 3.49946E-03 None 0 0 None 9.8E-05 None 0 3.95006E-04 1.93852E-03
S/N 181 Ig-2 78 rs72647843 0.192 -0.089 0.002 D 0.296 0.157 None gnomAD-3.1.2 1.64213E-02 None None None -0.285(TCAP) I None 5.66739E-02 6.21402E-03 0 0 1.92456E-04 None 0 9.49367E-03 3.67485E-04 2.07039E-04 1.24283E-02
S/N 181 Ig-2 78 rs72647843 0.192 -0.089 0.002 D 0.296 0.157 None 1000 genomes 1.81709E-02 None None None -0.285(TCAP) I None 6.58E-02 5.8E-03 None None 0 0 None None None 0 None
S/N 181 Ig-2 78 rs72647843 0.192 -0.089 0.002 D 0.296 0.157 None gnomAD-4.0.0 3.19547E-03 None None None -0.285(TCAP) I None 5.76554E-02 4.26439E-03 None 0 4.45593E-05 None 0 3.13428E-03 2.33898E-04 1.20768E-04 4.28745E-03
S/R 181 Ig-2 78 None 0.6466 None 0.998 N 0.417 0.56 0.455173453901 gnomAD-4.0.0 6.84065E-07 None None None 0.244(TCAP) I None 0 0 None 0 0 None 0 0 8.993E-07 0 0
S/T 181 Ig-2 78 None 0.1035 None 0.639 N 0.386 0.196 0.235038932564 gnomAD-4.0.0 6.8406E-07 None None None -0.245(TCAP) I None 0 0 None 0 0 None 0 0 8.99297E-07 0 0
E/A 1020 Ig-3 78 None 0.1773 None 0.896 N 0.438 0.463 0.487843537783 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/G 1535 Ig-6 79 rs2092354314 0.7246 None 1.0 N 0.604 0.491 0.545173277474 gnomAD-4.0.0 3.42088E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59744E-06 0 1.65607E-05
R/K 1535 Ig-6 79 None 0.2446 None 0.997 N 0.507 0.333 0.465806656444 gnomAD-4.0.0 1.59112E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85716E-06 0 0
K/E 1635 Ig-7 80 rs776274777 0.721 0.016 0.999 N 0.598 0.475 0.38225645794 gnomAD-2.1.1 7.99E-06 None None None None I None 0 5.8E-05 None 0 0 None 0 None 0 0 0
K/E 1635 Ig-7 80 rs776274777 0.721 0.016 0.999 N 0.598 0.475 0.38225645794 gnomAD-4.0.0 3.18202E-06 None None None None I None 0 4.57561E-05 None 0 0 None 0 0 0 0 0
K/R 1782 Ig-8 80 None 0.1434 None 0.998 N 0.458 0.323 0.293147016451 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
P/T 1917 Ig-9 77 None 0.1541 None 1.0 N 0.616 0.552 0.49676076625 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/L 2156 Ig-10 79 rs751393901 0.2037 -0.156 0.19 N 0.335 0.038 0.367612772649 gnomAD-2.1.1 7.97E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.76E-05 0
I/L 2156 Ig-10 79 rs751393901 0.2037 -0.156 0.19 N 0.335 0.038 0.367612772649 gnomAD-4.0.0 1.36819E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79859E-06 0 0
I/T 2156 Ig-10 79 None 0.3062 None 0.722 N 0.367 0.287 0.627921267029 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 2156 Ig-10 79 rs751393901 0.0938 -0.229 0.001 N 0.205 0.043 0.432604763906 gnomAD-2.1.1 3.19E-05 None None None None I None 0 2.31562E-04 None 0 0 None 0 None 0 0 0
I/V 2156 Ig-10 79 rs751393901 0.0938 -0.229 0.001 N 0.205 0.043 0.432604763906 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
I/V 2156 Ig-10 79 rs751393901 0.0938 -0.229 0.001 N 0.205 0.043 0.432604763906 gnomAD-4.0.0 6.19594E-06 None None None None I None 0 1.5003E-04 None 0 0 None 0 0 8.4745E-07 0 0
D/E 2251 Ig-11 78 None 0.19 None 0.767 N 0.482 0.092 0.0806252709748 gnomAD-4.0.0 1.36839E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79877E-06 0 0
D/H 2251 Ig-11 78 rs942953757 0.3297 0.325 1.0 N 0.711 0.407 0.130388298395 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
D/H 2251 Ig-11 78 rs942953757 0.3297 0.325 1.0 N 0.711 0.407 0.130388298395 gnomAD-4.0.0 2.73742E-06 None None None None N None 0 0 None 0 0 None 0 0 3.598E-06 0 0
D/N 2251 Ig-11 78 rs942953757 0.0884 0.415 0.999 N 0.693 0.279 0.141422826196 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 2251 Ig-11 78 rs942953757 0.0884 0.415 0.999 N 0.693 0.279 0.141422826196 gnomAD-4.0.0 6.57263E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47011E-05 0 0
D/V 2251 Ig-11 78 None 0.2738 None 0.999 N 0.719 0.483 0.357929162469 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/F 2432 Ig-13 77 rs571572592 0.1128 -0.6 0.896 N 0.305 0.271 0.46123363591 gnomAD-2.1.1 7.99E-06 None None None None I None 6.15E-05 0 None 0 5.45E-05 None 0 None 0 0 0
L/F 2432 Ig-13 77 rs571572592 0.1128 -0.6 0.896 N 0.305 0.271 0.46123363591 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
L/F 2432 Ig-13 77 rs571572592 0.1128 -0.6 0.896 N 0.305 0.271 0.46123363591 gnomAD-4.0.0 6.56694E-06 None None None None I None 2.40639E-05 0 None 0 0 None 0 0 0 0 0
N/D 2609 Ig-15 77 None 0.2095 None 0.425 N 0.279 0.179 0.241664281697 gnomAD-4.0.0 1.59106E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85719E-06 0 0
S/P 2696 Ig-16 76 None 0.9518 None 1.0 D 0.803 0.623 0.510700632011 gnomAD-4.0.0 1.59067E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
L/I 2784 Ig-17 78 None 0.0827 None 0.117 D 0.211 0.193 0.386395597597 gnomAD-4.0.0 1.59055E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85649E-06 0 0
L/P 2784 Ig-17 78 None 0.6676 None 0.999 D 0.786 0.715 0.904605819014 gnomAD-4.0.0 2.73631E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59717E-06 0 0
L/R 2784 Ig-17 78 rs766041336 0.3482 -0.089 0.999 D 0.781 0.662 0.885753467148 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
L/R 2784 Ig-17 78 rs766041336 0.3482 -0.089 0.999 D 0.781 0.662 0.885753467148 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.78927E-04
L/R 2784 Ig-17 78 rs766041336 0.3482 -0.089 0.999 D 0.781 0.662 0.885753467148 gnomAD-4.0.0 1.23904E-06 None None None None N None 0 0 None 0 0 None 0 0 8.47445E-07 0 1.59995E-05
D/G 2958 Ig-19 77 None 0.7758 None 0.998 N 0.637 0.759 0.324436698001 gnomAD-4.0.0 1.5916E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
D/Y 2958 Ig-19 77 rs745379216 0.7576 -0.047 1.0 N 0.762 0.665 0.712699868057 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
D/Y 2958 Ig-19 77 rs745379216 0.7576 -0.047 1.0 N 0.762 0.665 0.712699868057 gnomAD-4.0.0 3.18347E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85799E-06 1.43365E-05 0
N/I 3134 Ig-21 77 None 0.4995 None 0.994 N 0.713 0.377 0.672435393608 gnomAD-4.0.0 1.36814E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79859E-06 0 0
N/K 3134 Ig-21 77 rs587780987 0.7073 None 0.984 N 0.449 0.293 0.269111216191 gnomAD-4.0.0 1.36815E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79859E-06 0 0
N/S 3134 Ig-21 77 rs777759635 0.1156 -0.361 0.287 N 0.105 0.105 0.132336055621 gnomAD-2.1.1 7.97E-06 None None None None N None 0 5.78E-05 None 0 0 None 0 None 0 0 0
N/S 3134 Ig-21 77 rs777759635 0.1156 -0.361 0.287 N 0.105 0.105 0.132336055621 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.54E-05 0 0 0 None 0 0 0 0 0
N/S 3134 Ig-21 77 rs777759635 0.1156 -0.361 0.287 N 0.105 0.105 0.132336055621 gnomAD-4.0.0 4.95611E-06 None None None None N None 1.33234E-05 6.66378E-05 None 0 0 None 0 0 8.47455E-07 2.19568E-05 0
D/A 3316 Ig-23 78 rs780889180 0.3594 None 0.999 N 0.547 0.602 0.478451964739 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
D/A 3316 Ig-23 78 rs780889180 0.3594 None 0.999 N 0.547 0.602 0.478451964739 gnomAD-4.0.0 6.56927E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.07125E-04 0
D/G 3316 Ig-23 78 rs780889180 0.4489 -0.132 0.998 N 0.572 0.668 0.332646915603 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.84E-06 0
D/G 3316 Ig-23 78 rs780889180 0.4489 -0.132 0.998 N 0.572 0.668 0.332646915603 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 3316 Ig-23 78 None 0.2062 None 0.999 N 0.627 0.275 0.337868961071 gnomAD-4.0.0 1.59056E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02188E-05
S/G 3544 Ig-25 80 rs1364238345 0.1115 None None None None 0.09 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/G 3544 Ig-25 80 rs1364238345 0.1115 None None None None 0.09 None gnomAD-4.0.0 6.57091E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46998E-05 0 0
D/N 3737 Ig-26 78 rs1243794346 0.0806 0.669 None None None 0.157 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/N 3737 Ig-26 78 rs1243794346 0.0806 0.669 None None None 0.157 None gnomAD-4.0.0 1.59157E-06 None None None None I None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
D/E 3897 Ig-27 78 None 0.1317 None None N 0.067 0.076 None gnomAD-4.0.0 4.80129E-06 None None None None I None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
D/N 3897 Ig-27 78 None 0.0999 None 0.014 N 0.229 0.132 None gnomAD-4.0.0 7.52618E-06 None None None None I None 0 0 None 0 0 None 0 0 8.09497E-06 0 3.3129E-05
D/V 3897 Ig-27 78 rs2082481128 0.1494 None None N 0.106 0.187 None gnomAD-4.0.0 4.78933E-06 None None None None I None 0 0 None 0 1.76411E-04 None 0 0 0 0 0
D/Y 3897 Ig-27 78 rs1300532206 0.1609 0.098 0.065 N 0.233 0.137 None gnomAD-2.1.1 3.19E-05 None None None None I None 0 1.17924E-03 None 0 0 None 0 None 0 0 0
D/Y 3897 Ig-27 78 rs1300532206 0.1609 0.098 0.065 N 0.233 0.137 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
D/Y 3897 Ig-27 78 rs1300532206 0.1609 0.098 0.065 N 0.233 0.137 None gnomAD-4.0.0 8.67564E-06 None None None None I None 0 1.66744E-05 None 0 0 None 0 0 1.0171E-05 0 1.60102E-05
M/I 4016 Ig-28 79 rs528996964 0.15 0.425 None N 0.138 0.116 None gnomAD-2.1.1 4.29E-05 None None None None I None 4.13E-05 0 None 0 0 None 0 None 0 8.61E-05 0
M/I 4016 Ig-28 79 rs528996964 0.15 0.425 None N 0.138 0.116 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
M/I 4016 Ig-28 79 rs528996964 0.15 0.425 None N 0.138 0.116 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
M/I 4016 Ig-28 79 rs528996964 0.15 0.425 None N 0.138 0.116 None gnomAD-4.0.0 1.85941E-06 None None None None I None 1.33262E-05 0 None 0 0 None 0 0 1.69514E-06 0 0
M/T 4016 Ig-28 79 rs760386971 0.0911 0.646 None N 0.167 0.095 None gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
M/T 4016 Ig-28 79 rs760386971 0.0911 0.646 None N 0.167 0.095 None gnomAD-4.0.0 4.77699E-06 None None None None I None 0 2.28666E-05 None 0 0 None 0 0 2.85791E-06 0 3.02444E-05
M/V 4016 Ig-28 79 rs908523887 0.061 0.352 None N 0.137 0.082 None gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 9.81E-05 None 0 0 0
M/V 4016 Ig-28 79 rs908523887 0.061 0.352 None N 0.137 0.082 None gnomAD-4.0.0 6.36949E-06 None None None None I None 0 0 None 0 0 None 0 0 0 5.73099E-05 0
D/G 4682 Ig-29 77 rs2082045865 0.1062 None None N 0.147 0.155 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/G 4682 Ig-29 77 rs2082045865 0.1062 None None N 0.147 0.155 None gnomAD-4.0.0 2.91265E-06 None None None None N None 1.78171E-05 0 None 0 2.48373E-05 None 0 0 0 0 0
E/A 4777 Ig-30 78 rs747457945 0.1591 0.107 0.425 N 0.329 0.256 None gnomAD-2.1.1 1.21E-05 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 1.78E-05 0
E/A 4777 Ig-30 78 rs747457945 0.1591 0.107 0.425 N 0.329 0.256 None gnomAD-3.1.2 1.97E-05 None None None None I None 7.23E-05 0 0 0 0 None 0 0 0 0 0
E/A 4777 Ig-30 78 rs747457945 0.1591 0.107 0.425 N 0.329 0.256 None gnomAD-4.0.0 2.35483E-05 None None None None I None 4.00352E-05 0 None 0 0 None 0 0 2.88192E-05 0 1.60123E-05
E/K 4777 Ig-30 78 rs1405978578 0.1416 0.652 0.27 N 0.269 0.26 0.276898752692 gnomAD-2.1.1 4.02E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
E/K 4777 Ig-30 78 rs1405978578 0.1416 0.652 0.27 N 0.269 0.26 0.276898752692 gnomAD-4.0.0 1.59146E-06 None None None None I None 5.65547E-05 0 None 0 0 None 0 0 0 0 0
E/V 4777 Ig-30 78 None 0.2357 None 0.784 N 0.358 0.35 0.448498829774 gnomAD-4.0.0 6.84233E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99493E-07 0 0
K/E 4872 Ig-31 78 None 0.3123 None 0.134 N 0.324 0.141 0.249502417897 gnomAD-4.0.0 1.59145E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
K/N 4872 Ig-31 78 rs771719584 0.5685 0.229 0.92 N 0.431 0.258 0.173771789658 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
K/N 4872 Ig-31 78 rs771719584 0.5685 0.229 0.92 N 0.431 0.258 0.173771789658 gnomAD-4.0.0 4.10548E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49735E-06 0 1.657E-05
E/K 4965 Ig-32 78 rs2081295922 0.172 None 0.977 N 0.551 0.369 0.451692371253 gnomAD-4.0.0 2.06523E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70564E-06 0 0
D/E 5059 Ig-33 79 rs74607159 0.1345 None 0.015 N 0.214 0.151 0.0401082797425 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/E 5059 Ig-33 79 rs74607159 0.1345 None 0.015 N 0.214 0.151 0.0401082797425 gnomAD-4.0.0 6.57142E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47011E-05 0 0
D/G 5059 Ig-33 79 rs1422502789 0.1914 0.061 0.822 N 0.402 0.464 0.27132560031 gnomAD-2.1.1 4.02E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
D/N 5059 Ig-33 79 rs770418360 0.1261 0.467 0.025 N 0.205 0.219 0.226586394389 gnomAD-2.1.1 7.24E-05 None None None None I None 0 5.22193E-04 None 0 0 None 0 None 0 0 0
D/N 5059 Ig-33 79 rs770418360 0.1261 0.467 0.025 N 0.205 0.219 0.226586394389 gnomAD-3.1.2 1.97E-05 None None None None I None 0 1.96464E-04 0 0 0 None 0 0 0 0 0
D/N 5059 Ig-33 79 rs770418360 0.1261 0.467 0.025 N 0.205 0.219 0.226586394389 gnomAD-4.0.0 2.94992E-05 None None None None I None 0 3.9028E-04 None 0 0 None 0 0 0 0 0
E/K 5152 Ig-34 78 None 0.3815 None 0.978 N 0.541 0.38 0.455996456696 gnomAD-4.0.0 6.86655E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.16902E-05 0
S/F 5434 Ig-37 78 None 0.202 None 0.998 N 0.521 0.472 0.818133683601 gnomAD-4.0.0 1.59227E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85969E-06 0 0
V/A 5527 Ig-38 78 rs541467635 0.0765 -0.118 None N 0.147 0.133 0.446310458034 gnomAD-2.1.1 4.03E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
V/A 5527 Ig-38 78 rs541467635 0.0765 -0.118 None N 0.147 0.133 0.446310458034 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/A 5527 Ig-38 78 rs541467635 0.0765 -0.118 None N 0.147 0.133 0.446310458034 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
V/A 5527 Ig-38 78 rs541467635 0.0765 -0.118 None N 0.147 0.133 0.446310458034 gnomAD-4.0.0 6.56564E-06 None None None None I None 2.40512E-05 0 None 0 0 None 0 0 0 0 0
V/I 5527 Ig-38 78 rs1334663895 0.0715 -0.139 None N 0.251 0.086 0.306377322295 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.59E-05 None 0 None 0 0 0
V/I 5527 Ig-38 78 rs1334663895 0.0715 -0.139 None N 0.251 0.086 0.306377322295 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92604E-04 None 0 0 0 0 0
V/I 5527 Ig-38 78 rs1334663895 0.0715 -0.139 None N 0.251 0.086 0.306377322295 gnomAD-4.0.0 5.12909E-06 None None None None I None 0 0 None 0 2.4266E-05 None 0 0 7.18725E-06 0 0
E/G 5714 Ig-40 78 rs772995909 0.2954 0.017 0.351 N 0.384 0.159 0.355865052028 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
E/G 5714 Ig-40 78 rs772995909 0.2954 0.017 0.351 N 0.384 0.159 0.355865052028 gnomAD-4.0.0 1.36862E-06 None None None None I None 0 0 None 0 2.52029E-05 None 0 0 8.99567E-07 0 0
D/G 5807 Ig-41 78 rs1167663430 0.474 0.173 0.896 N 0.418 0.31 0.333154297509 gnomAD-2.1.1 3.18E-05 None None None None I None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
D/H 5807 Ig-41 78 None 0.6038 None 0.984 N 0.449 0.288 0.378674557249 gnomAD-4.0.0 1.59126E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85838E-06 0 0
D/V 5807 Ig-41 78 None 0.3685 None 0.984 N 0.474 0.477 0.53099781502 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/Y 5807 Ig-41 78 rs548385039 0.4958 0.13 0.995 N 0.541 0.328 0.643388216043 gnomAD-2.1.1 3.18E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
D/Y 5807 Ig-41 78 rs548385039 0.4958 0.13 0.995 N 0.541 0.328 0.643388216043 gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 0 None 0 0 5.88E-05 0 0
D/Y 5807 Ig-41 78 rs548385039 0.4958 0.13 0.995 N 0.541 0.328 0.643388216043 gnomAD-4.0.0 1.02486E-05 None None None None I None 0 0 None 0 0 None 0 0 1.91442E-05 0 0
D/Y 5900 Ig-42 78 None 0.3122 None 1.0 N 0.718 0.512 0.78712903431 gnomAD-4.0.0 6.00162E-06 None None None None I None 0 0 None 0 0 None 0 0 6.56252E-06 0 0
D/E 6089 Ig-44 78 rs754848806 0.1425 -0.015 0.767 N 0.359 0.147 0.183819452728 gnomAD-2.1.1 2.02E-05 None None None None I None 0 2.91E-05 None 0 0 None 0 None 0 3.57E-05 0
D/E 6089 Ig-44 78 rs754848806 0.1425 -0.015 0.767 N 0.359 0.147 0.183819452728 gnomAD-3.1.2 4.6E-05 None None None None I None 0 0 2.1978E-03 0 0 None 0 0 7.35E-05 0 0
D/E 6089 Ig-44 78 rs754848806 0.1425 -0.015 0.767 N 0.359 0.147 0.183819452728 gnomAD-4.0.0 3.90532E-05 None None None None I None 0 1.66928E-05 None 0 1.11632E-04 None 0 0 4.49307E-05 0 3.20379E-05
D/G 6089 Ig-44 78 None 0.2771 None 0.998 N 0.553 0.485 0.326881540566 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
D/N 6089 Ig-44 78 rs560203827 0.1475 0.554 0.999 N 0.621 0.273 0.335661160332 gnomAD-2.1.1 7.26E-05 None None None None I None 0 0 None 0 0 None 5.24109E-04 None 0 1.78E-05 0
D/N 6089 Ig-44 78 rs560203827 0.1475 0.554 0.999 N 0.621 0.273 0.335661160332 gnomAD-3.1.2 4.01E-05 None None None None I None 0 0 0 0 0 None 0 0 0 1.33333E-03 0
D/N 6089 Ig-44 78 rs560203827 0.1475 0.554 0.999 N 0.621 0.273 0.335661160332 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
D/N 6089 Ig-44 78 rs560203827 0.1475 0.554 0.999 N 0.621 0.273 0.335661160332 gnomAD-4.0.0 3.22188E-05 None None None None I None 0 0 None 0 0 None 0 0 2.58466E-06 5.08602E-04 3.30622E-05
D/G 6183 Ig-45 79 None 0.1486 None 0.969 N 0.5 0.432 0.382087116544 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 6183 Ig-45 79 None 0.0994 None 0.939 N 0.449 0.265 0.456089687795 gnomAD-4.0.0 1.59139E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85863E-06 0 0
E/G 6369 Ig-47 78 None 0.2226 None 0.994 N 0.401 0.568 0.499218193508 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
E/K 6369 Ig-47 78 rs776552344 0.1912 0.899 0.978 N 0.473 0.317 0.409937222855 gnomAD-2.1.1 4.06E-06 None None None None I None 0 0 None 0 0 None 3.32E-05 None 0 0 0
E/K 6369 Ig-47 78 rs776552344 0.1912 0.899 0.978 N 0.473 0.317 0.409937222855 gnomAD-4.0.0 6.85388E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.16501E-05 0
E/Q 6369 Ig-47 78 rs776552344 0.1972 0.654 0.889 N 0.396 0.193 0.415055319159 gnomAD-2.1.1 4.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.96E-06 0
E/Q 6369 Ig-47 78 rs776552344 0.1972 0.654 0.889 N 0.396 0.193 0.415055319159 gnomAD-4.0.0 3.42694E-06 None None None None I None 0 0 None 0 0 None 0 0 4.5024E-06 0 0
D/A 6462 Ig-48 78 rs1419616263 0.1375 -0.114 0.896 N 0.405 0.336 0.416581338634 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.66889E-04
D/A 6462 Ig-48 78 rs1419616263 0.1375 -0.114 0.896 N 0.405 0.336 0.416581338634 gnomAD-4.0.0 2.05436E-06 None None None None I None 0 0 None 0 0 None 0 0 9.00015E-07 1.1609E-05 1.6581E-05
V/I 6558 Ig-49 78 rs879223660 0.0753 -0.105 0.001 N 0.247 0.121 None gnomAD-2.1.1 4.11E-06 None None None None I None 6.54E-05 0 None 0 0 None 0 None 0 0 0
V/I 6558 Ig-49 78 rs879223660 0.0753 -0.105 0.001 N 0.247 0.121 None gnomAD-3.1.2 3.29E-05 None None None None I None 1.20691E-04 0 0 0 0 None 0 0 0 0 0
V/I 6558 Ig-49 78 rs879223660 0.0753 -0.105 0.001 N 0.247 0.121 None gnomAD-4.0.0 3.73447E-06 None None None None I None 8.02826E-05 0 None 0 0 None 0 0 0 0 0
P/S 6745 Ig-51 79 rs756864644 0.1064 -0.098 0.801 N 0.351 0.199 0.264547087235 gnomAD-2.1.1 2.87E-05 None None None None I None 0 0 None 0 0 None 2.36423E-04 None 0 0 0
P/S 6745 Ig-51 79 rs756864644 0.1064 -0.098 0.801 N 0.351 0.199 0.264547087235 gnomAD-4.0.0 1.45056E-05 None None None None I None 0 0 None 0 0 None 0 0 9.06541E-07 2.38983E-04 0
P/T 6745 Ig-51 79 None 0.0869 None 0.891 N 0.362 0.205 0.465975295344 gnomAD-4.0.0 6.90741E-07 None None None None I None 0 0 None 0 0 None 0 0 9.06541E-07 0 0
N/S 7025 Ig-54 78 rs2078960594 0.0691 None 0.166 N 0.358 0.215 0.146414634003 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
N/S 7025 Ig-54 78 rs2078960594 0.0691 None 0.166 N 0.358 0.215 0.146414634003 gnomAD-4.0.0 6.57324E-06 None None None None I None 2.41243E-05 0 None 0 0 None 0 0 0 0 0
N/Y 7025 Ig-54 78 None 0.165 None 0.629 N 0.295 0.299 0.521173705876 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/D 7121 Ig-55 78 rs1276789641 0.1805 0.081 0.055 N 0.294 0.219 0.48461828368 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/D 7121 Ig-55 78 rs1276789641 0.1805 0.081 0.055 N 0.294 0.219 0.48461828368 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
V/D 7121 Ig-55 78 rs1276789641 0.1805 0.081 0.055 N 0.294 0.219 0.48461828368 gnomAD-4.0.0 3.84604E-06 None None None None I None 0 0 None 0 0 None 0 0 0 4.02296E-05 0
V/I 7121 Ig-55 78 rs893277923 0.0745 None 0.055 N 0.32 0.163 0.390842690916 gnomAD-4.0.0 2.73792E-06 None None None None I None 2.99079E-05 0 None 0 0 None 0 0 1.79956E-06 0 1.65717E-05
N/D 7214 Ig-56 78 rs998292768 0.0513 None None N 0.093 0.25 0.0401082797425 gnomAD-4.0.0 3.18527E-06 None None None None I None 0 0 None 0 0 None 0 0 5.72007E-06 0 0
N/S 7214 Ig-56 78 rs755600935 0.0653 0.258 0.005 N 0.178 0.1 0.117506650769 gnomAD-2.1.1 4.03E-06 None None None None I None 6.47E-05 0 None 0 0 None 0 None 0 0 0
S/G 7400 Ig-58 78 None 0.0716 None 0.101 N 0.285 0.099 0.228597637076 gnomAD-4.0.0 1.59289E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86054E-06 0 0
D/E 7592 Ig-60 78 None 0.115 None 0.046 N 0.345 0.059 0.17258766438 gnomAD-4.0.0 6.84583E-07 None None None None I None 0 0 None 0 2.51953E-05 None 0 0 0 0 0
E/D 7779 Ig-62 78 rs1253898130 0.1134 None 0.014 N 0.341 0.226 0.200317383148 gnomAD-4.0.0 3.18402E-06 None None None None I None 0 0 None 0 5.54662E-05 None 0 0 0 0 0
E/K 7779 Ig-62 78 rs1314203498 0.3911 None 0.822 N 0.474 0.342 0.40528724903 gnomAD-4.0.0 6.84315E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99572E-07 0 0
D/G 7873 Ig-63 79 None 0.4976 None 0.801 D 0.382 0.259 0.365892764245 gnomAD-4.0.0 1.59325E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.4339E-05 0
D/N 7873 Ig-63 79 rs753929851 0.2245 0.579 0.233 N 0.375 0.208 0.33110744837 gnomAD-2.1.1 7.17E-06 None None None None I None 8.3E-05 0 None 0 0 None 0 None 0 0 0
D/N 7873 Ig-63 79 rs753929851 0.2245 0.579 0.233 N 0.375 0.208 0.33110744837 gnomAD-3.1.2 1.31E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
D/N 7873 Ig-63 79 rs753929851 0.2245 0.579 0.233 N 0.375 0.208 0.33110744837 gnomAD-4.0.0 4.34016E-06 None None None None I None 8.01475E-05 0 None 0 0 None 0 0 0 0 1.60231E-05
S/G 7966 Ig-64 78 rs766127559 0.0795 -0.228 0.012 N 0.214 0.159 0.173771789658 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
S/G 7966 Ig-64 78 rs766127559 0.0795 -0.228 0.012 N 0.214 0.159 0.173771789658 gnomAD-4.0.0 6.37885E-06 None None None None N None 0 0 None 0 0 None 0 0 8.60289E-06 1.43382E-05 0
S/R 7966 Ig-64 78 rs773116614 0.2024 0.124 None N 0.197 0.142 0.311691414656 gnomAD-2.1.1 1.59307E-04 None None None None N None 0 0 None 0 0 None 0 None 0 3.24044E-04 0
S/R 7966 Ig-64 78 rs773116614 0.2024 0.124 None N 0.197 0.142 0.311691414656 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 7.35E-05 0 0
S/R 7966 Ig-64 78 rs773116614 0.2024 0.124 None N 0.197 0.142 0.311691414656 gnomAD-4.0.0 3.72202E-06 None None None None N None 0 0 None 0 0 None 0 0 5.09163E-06 0 0
S/T 7966 Ig-64 78 rs762651037 0.0716 0.062 0.024 D 0.229 0.162 0.178374595973 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
S/T 7966 Ig-64 78 rs762651037 0.0716 0.062 0.024 D 0.229 0.162 0.178374595973 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/T 7966 Ig-64 78 rs762651037 0.0716 0.062 0.024 D 0.229 0.162 0.178374595973 gnomAD-4.0.0 4.96211E-06 None None None None N None 0 0 None 0 0 None 0 0 5.09103E-06 0 3.20574E-05
V/I 8062 Ig-65 78 rs879134005 0.0759 -0.081 0.003 N 0.22 0.055 0.156986980423 gnomAD-2.1.1 4.04E-06 None None None None I None 6.48E-05 0 None 0 0 None 0 None 0 0 0
V/I 8062 Ig-65 78 rs879134005 0.0759 -0.081 0.003 N 0.22 0.055 0.156986980423 gnomAD-4.0.0 1.59143E-06 None None None None I None 5.65675E-05 0 None 0 0 None 0 0 0 0 0
S/R 8341 Ig-68 78 rs1221926854 0.475 0.083 0.132 N 0.379 0.306 0.0666544352282 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
S/R 8341 Ig-68 78 rs1221926854 0.475 0.083 0.132 N 0.379 0.306 0.0666544352282 gnomAD-4.0.0 6.84318E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99638E-07 0 0
P/L 8437 Ig-69 78 rs1560631696 0.0949 None 0.043 N 0.233 0.175 0.523702305895 gnomAD-4.0.0 6.84728E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9997E-07 0 0
P/R 8437 Ig-69 78 rs1560631696 0.1556 None 0.178 N 0.269 0.204 0.363158594168 gnomAD-4.0.0 6.84728E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9997E-07 0 0
I/F 8533 Ig-70 78 None 0.0952 None 0.016 D 0.307 0.056 0.313518423057 gnomAD-4.0.0 1.36878E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79934E-06 0 0
I/N 8533 Ig-70 78 None 0.074 None None N 0.164 0.118 0.237489013734 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 8533 Ig-70 78 rs367921306 0.0571 -0.064 None N 0.121 0.094 0.21279746466 gnomAD-2.1.1 2.82E-05 None None None None I None 0 0 None 0 3.34336E-04 None 3.27E-05 None 0 0 0
I/V 8533 Ig-70 78 rs367921306 0.0571 -0.064 None N 0.121 0.094 0.21279746466 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 5.79374E-04 None 0 0 0 0 0
I/V 8533 Ig-70 78 rs367921306 0.0571 -0.064 None N 0.121 0.094 0.21279746466 1000 genomes 3.99361E-04 None None None None I None 0 0 None None 2E-03 0 None None None 0 None
I/V 8533 Ig-70 78 rs367921306 0.0571 -0.064 None N 0.121 0.094 0.21279746466 gnomAD-4.0.0 1.23959E-05 None None None None I None 0 0 None 0 2.45251E-04 None 0 0 0 4.393E-05 8.00512E-05
A/V 8627 Ig-71 79 rs1349154909 0.0845 -0.088 0.008 N 0.202 0.169 0.431490205687 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
A/V 8627 Ig-71 79 rs1349154909 0.0845 -0.088 0.008 N 0.202 0.169 0.431490205687 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/V 8627 Ig-71 79 rs1349154909 0.0845 -0.088 0.008 N 0.202 0.169 0.431490205687 gnomAD-4.0.0 2.02993E-06 None None None None I None 0 0 None 0 0 None 0 0 2.40985E-06 0 0
D/N 8720 Ig-72 78 rs980079508 0.1135 0.565 0.008 N 0.269 0.198 0.288727942641 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
D/N 8720 Ig-72 78 rs980079508 0.1135 0.565 0.008 N 0.269 0.198 0.288727942641 gnomAD-4.0.0 2.05364E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69958E-06 0 0
D/Y 8720 Ig-72 78 rs980079508 0.2445 None 0.991 N 0.342 0.344 0.53371040847 gnomAD-4.0.0 2.73818E-06 None None None None I None 8.97076E-05 0 None 0 0 None 0 0 8.99858E-07 0 0
D/N 8814 Ig-73 79 rs1035364658 0.0992 0.593 0.999 N 0.587 0.324 0.476676017676 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/N 8814 Ig-73 79 rs1035364658 0.0992 0.593 0.999 N 0.587 0.324 0.476676017676 gnomAD-4.0.0 1.59175E-06 None None None None I None 0 2.28666E-05 None 0 0 None 0 0 0 0 0
D/Y 8814 Ig-73 79 rs1035364658 0.2226 None 1.0 N 0.734 0.378 0.633624541524 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92901E-04 None 0 0 0 0 0
D/Y 8814 Ig-73 79 rs1035364658 0.2226 None 1.0 N 0.734 0.378 0.633624541524 gnomAD-4.0.0 6.57315E-06 None None None None I None 0 0 None 0 1.92901E-04 None 0 0 0 0 0
P/A 8907 Ig-74 78 None 0.0596 -0.146 0.003 N 0.221 0.114 0.17258766438 gnomAD-2.1.1 4.02E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
P/A 8907 Ig-74 78 None 0.0596 -0.146 0.003 N 0.221 0.114 0.17258766438 gnomAD-3.1.2 2.63E-05 None None None None I None 9.66E-05 0 0 0 0 None 0 0 0 0 0
P/A 8907 Ig-74 78 None 0.0596 -0.146 0.003 N 0.221 0.114 0.17258766438 gnomAD-4.0.0 3.09891E-06 None None None None I None 6.67806E-05 0 None 0 0 None 0 0 0 0 0
P/S 8907 Ig-74 78 rs764261158 0.0773 None None N 0.089 0.091 0.132336055621 gnomAD-2.1.1 4.02E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
P/S 8907 Ig-74 78 rs764261158 0.0773 None None N 0.089 0.091 0.132336055621 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/S 8907 Ig-74 78 rs764261158 0.0773 None None N 0.089 0.091 0.132336055621 gnomAD-4.0.0 5.57805E-06 None None None None I None 2.67123E-05 0 None 0 0 None 0 0 5.93372E-06 0 0
P/T 8907 Ig-74 78 rs764261158 0.0638 None None N 0.101 0.108 0.268211541103 gnomAD-4.0.0 4.10576E-06 None None None None I None 0 0 None 0 0 None 0 0 5.39729E-06 0 0
M/I 9003 Ig-75 78 None 0.0947 None None N 0.181 0.137 0.15556083564 gnomAD-4.0.0 1.3685E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.31916E-05 0
M/T 9003 Ig-75 78 rs2076906083 0.0736 None None N 0.183 0.098 0.393775345888 gnomAD-4.0.0 4.78977E-06 None None None None I None 8.96325E-05 0 None 0 2.52016E-05 None 0 0 1.79901E-06 1.15955E-05 0
M/V 9003 Ig-75 78 None 0.0459 None None N 0.173 0.074 0.165133752707 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 6.17284E-04 0 0 0
E/D 9096 Ig-76 78 rs775382008 0.0853 -0.03 0.001 N 0.137 0.097 0.151104730317 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/D 9096 Ig-76 78 rs775382008 0.0853 -0.03 0.001 N 0.137 0.097 0.151104730317 gnomAD-4.0.0 1.59138E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
A/G 9189 Ig-77 78 None 0.1259 None None N 0.195 0.075 0.301455362545 gnomAD-4.0.0 6.84231E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99468E-07 0 0
A/V 9189 Ig-77 78 None 0.0937 None 0.062 N 0.219 0.111 None gnomAD-4.0.0 8.21078E-06 None None None None I None 2.98829E-05 0 None 0 0 None 0 0 8.99468E-06 0 1.65651E-05
S/R 9282 Ig-78 78 rs771474147 0.3744 0.104 0.014 N 0.225 0.277 0.126345400529 gnomAD-2.1.1 1.62E-05 None None None None I None 0 0 None 0 0 None 0 None 0 3.58E-05 0
S/R 9282 Ig-78 78 rs771474147 0.3744 0.104 0.014 N 0.225 0.277 0.126345400529 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
S/R 9282 Ig-78 78 rs771474147 0.3744 0.104 0.014 N 0.225 0.277 0.126345400529 gnomAD-4.0.0 7.72758E-06 None None None None I None 0 0 None 0 0 None 0 0 1.44615E-05 0 0
P/S 9378 Ig-79 78 rs879082824 0.0874 None 0.01 None 0.081 0.162 0.159798565429 gnomAD-3.1.2 1.31E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
P/S 9378 Ig-79 78 rs879082824 0.0874 None 0.01 None 0.081 0.162 0.159798565429 gnomAD-4.0.0 6.20008E-06 None None None None I None 1.33526E-05 0 None 0 0 None 0 0 7.63137E-06 0 0
V/M 9667 Ig-82 78 None 0.1411 None 0.001 None 0.202 0.055 0.288727942641 gnomAD-4.0.0 1.59144E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43316E-05 0
E/D 9776 Ig-83 79 None 0.3013 None 0.001 None 0.271 0.092 0.18995819373 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 9776 Ig-83 79 rs143477225 0.045 0.7 None None 0.113 0.123 None gnomAD-2.1.1 3.61E-05 None None None None I None 6.46E-05 2.9E-05 None 0 0 None 6.54E-05 None 0 4.43E-05 0
E/K 9776 Ig-83 79 rs143477225 0.045 0.7 None None 0.113 0.123 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
E/K 9776 Ig-83 79 rs143477225 0.045 0.7 None None 0.113 0.123 None gnomAD-4.0.0 2.16879E-05 None None None None I None 1.33294E-05 3.33344E-05 None 0 0 None 0 0 2.20379E-05 5.49076E-05 1.60046E-05
E/Q 9776 Ig-83 79 None 0.1007 None None None 0.129 0.172 0.18995819373 gnomAD-4.0.0 6.84195E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99462E-07 0 0
P/L 10155 Ig-86 78 None 0.929 None 1.0 None 0.797 0.522 0.801471871174 gnomAD-4.0.0 1.59085E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85745E-06 0 0
G/R 13763 Ig-87 80 rs768683479 0.9654 -0.818 0.999 N 0.841 0.438 0.680007063485 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
G/R 13763 Ig-87 80 rs768683479 0.9654 -0.818 0.999 N 0.841 0.438 0.680007063485 gnomAD-4.0.0 2.05568E-06 None None None None N None 0 0 None 0 0 None 0 0 2.7011E-06 0 0
A/T 13857 Ig-88 78 rs144963490 0.1824 -1.79 0.919 N 0.498 0.086 None gnomAD-2.1.1 3.25E-05 None None None None N None 0 0 None 0 2.23839E-04 None 0 None 0 3.59E-05 0
A/T 13857 Ig-88 78 rs144963490 0.1824 -1.79 0.919 N 0.498 0.086 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 5.82072E-04 None 0 0 0 0 0
A/T 13857 Ig-88 78 rs144963490 0.1824 -1.79 0.919 N 0.498 0.086 None 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 2E-03 0 None None None 0 None
A/T 13857 Ig-88 78 rs144963490 0.1824 -1.79 0.919 N 0.498 0.086 None gnomAD-4.0.0 3.60309E-05 None None None None N None 0 0 None 0 1.09669E-03 None 0 0 6.79656E-06 1.10297E-05 0
A/V 13857 Ig-88 78 rs1308553972 0.3222 -0.394 0.005 N 0.093 0.099 0.247872288689 gnomAD-2.1.1 4.05E-06 None None None None N None 0 2.92E-05 None 0 0 None 0 None 0 0 0
A/V 13857 Ig-88 78 rs1308553972 0.3222 -0.394 0.005 N 0.093 0.099 0.247872288689 gnomAD-4.0.0 1.60055E-06 None None None None N None 0 2.29495E-05 None 0 0 None 0 0 0 0 0
A/V 14041 Ig-90 77 rs1174010742 0.6612 -0.137 0.999 N 0.675 0.318 0.37953744168 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
A/V 14041 Ig-90 77 rs1174010742 0.6612 -0.137 0.999 N 0.675 0.318 0.37953744168 gnomAD-4.0.0 3.18534E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86107E-06 1.43377E-05 0
K/E 14129 Ig-91 76 None 0.3725 None 0.996 N 0.501 0.286 0.388334884743 gnomAD-4.0.0 1.60068E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86582E-06 0 0
K/R 14129 Ig-91 76 None 0.1036 None 0.64 N 0.269 0.182 0.263140351381 gnomAD-4.0.0 6.85945E-07 None None None None N None 0 0 None 0 2.53062E-05 None 0 0 0 0 0
K/T 14129 Ig-91 76 rs1050750556 0.4682 None 0.999 N 0.615 0.423 0.527709697666 gnomAD-4.0.0 5.48756E-06 None None None None N None 0 0 None 0 0 None 0 0 7.20172E-06 0 0
D/E 14306 Ig-93 76 rs537375897 0.4514 -0.342 1.0 N 0.477 0.201 0.326616659874 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
D/E 14306 Ig-93 76 rs537375897 0.4514 -0.342 1.0 N 0.477 0.201 0.326616659874 gnomAD-4.0.0 2.73759E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99617E-07 3.47866E-05 0
K/E 14484 Ig-95 77 rs762264832 0.3281 -0.092 0.201 D 0.502 0.217 0.298745278005 gnomAD-2.1.1 1.79E-05 None None None None N None 4.13E-05 0 None 0 0 None 0 None 0 3.14E-05 0
K/E 14484 Ig-95 77 rs762264832 0.3281 -0.092 0.201 D 0.502 0.217 0.298745278005 gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
K/E 14484 Ig-95 77 rs762264832 0.3281 -0.092 0.201 D 0.502 0.217 0.298745278005 gnomAD-4.0.0 6.19865E-06 None None None None N None 4.00545E-05 0 None 0 0 None 0 0 4.2388E-06 0 3.2039E-05
K/N 14484 Ig-95 77 None 0.5646 None 0.015 N 0.267 0.105 0.144782658237 gnomAD-4.0.0 4.79094E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29742E-06 0 0
K/Q 14484 Ig-95 77 None 0.1866 None 0.004 N 0.236 0.153 0.184867976434 gnomAD-4.0.0 6.8441E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9963E-07 0 0
M/L 14573 Ig-96 77 rs755610701 0.0694 0.388 None N 0.083 0.147 0.17258766438 gnomAD-2.1.1 4.17E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.24E-06 0
M/L 14573 Ig-96 77 rs755610701 0.0694 0.388 None N 0.083 0.147 0.17258766438 gnomAD-4.0.0 2.06059E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70507E-06 0 0
M/V 14573 Ig-96 77 rs755610701 0.0842 0.197 None N 0.133 0.143 0.107399877778 gnomAD-2.1.1 1.47E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.23E-05 0
M/V 14573 Ig-96 77 rs755610701 0.0842 0.197 None N 0.133 0.143 0.107399877778 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/V 14573 Ig-96 77 rs755610701 0.0842 0.197 None N 0.133 0.143 0.107399877778 gnomAD-4.0.0 1.43037E-05 None None None None N None 0 0 None 0 0 None 0 0 1.95408E-05 0 0
D/A 14662 Ig-97 77 rs796538475 0.3442 -0.521 1.0 N 0.669 0.401 0.28297238246 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 0 9.19118E-04
D/A 14662 Ig-97 77 rs796538475 0.3442 -0.521 1.0 N 0.669 0.401 0.28297238246 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
D/A 14662 Ig-97 77 rs796538475 0.3442 -0.521 1.0 N 0.669 0.401 0.28297238246 gnomAD-4.0.0 8.67852E-06 None None None None N None 0 0 None 0 0 None 0 0 1.10208E-05 0 1.602E-05
D/E 14662 Ig-97 77 rs201390600 0.3713 -0.671 1.0 N 0.391 0.227 0.198526703765 gnomAD-2.1.1 8.23E-05 None None None None N None 0 3.96758E-04 None 0 0 None 0 None 0 4.7E-05 4.22893E-04
D/E 14662 Ig-97 77 rs201390600 0.3713 -0.671 1.0 N 0.391 0.227 0.198526703765 gnomAD-3.1.2 2.63E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 2.94E-05 0 4.79386E-04
D/E 14662 Ig-97 77 rs201390600 0.3713 -0.671 1.0 N 0.391 0.227 0.198526703765 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
D/E 14662 Ig-97 77 rs201390600 0.3713 -0.671 1.0 N 0.391 0.227 0.198526703765 gnomAD-4.0.0 4.40109E-05 None None None None N None 0 3.66862E-04 None 0 0 None 0 0 3.56058E-05 0 1.12104E-04
D/H 14662 Ig-97 77 rs876658059 0.6202 None 1.0 D 0.683 0.441 0.300449992093 gnomAD-4.0.0 1.59252E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85974E-06 0 0
V/I 14751 Ig-98 77 rs1293013607 0.1087 None 0.293 N 0.497 0.147 0.203808441222 gnomAD-4.0.0 6.00162E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 5.25002E-06 0 0
F/L 14840 Ig-99 76 rs1296759910 0.9549 -1.667 0.999 N 0.643 0.383 0.212008924253 gnomAD-2.1.1 4.08E-06 None None None None N None 0 0 None 0 0 None 3.34E-05 None 0 0 0
F/L 14840 Ig-99 76 rs1296759910 0.9549 -1.667 0.999 N 0.643 0.383 0.212008924253 gnomAD-4.0.0 4.81645E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.34682E-05 0
F/S 14840 Ig-99 76 rs886055276 0.8768 -3.418 1.0 N 0.709 0.452 0.546435761033 gnomAD-2.1.1 4.08E-06 None None None None N None 0 0 None 0 5.67E-05 None 0 None 0 0 0
F/S 14840 Ig-99 76 rs886055276 0.8768 -3.418 1.0 N 0.709 0.452 0.546435761033 gnomAD-4.0.0 1.60548E-06 None None None None N None 0 0 None 0 2.79783E-05 None 0 0 0 0 0
F/Y 14840 Ig-99 76 rs886055276 0.3558 None 0.999 N 0.617 0.262 0.304760801415 gnomAD-4.0.0 6.42191E-06 None None None None N None 0 0 None 0 0 None 0 0 1.15172E-05 0 0
A/E 15018 Ig-101 77 rs72677221 0.3785 -1.039 0.991 N 0.607 0.334 0.413241256734 gnomAD-2.1.1 1.21904E-04 None None None None N None 0 7.39645E-04 None 0 0 None 0 None 4.01E-05 5.49E-05 0
A/E 15018 Ig-101 77 rs72677221 0.3785 -1.039 0.991 N 0.607 0.334 0.413241256734 gnomAD-3.1.2 1.98E-05 None None None None N None 0 1.97135E-04 0 0 0 None 0 0 0 0 0
A/E 15018 Ig-101 77 rs72677221 0.3785 -1.039 0.991 N 0.607 0.334 0.413241256734 gnomAD-4.0.0 3.22591E-05 None None None None N None 0 5.35117E-04 None 0 0 None 4.69307E-05 0 1.35713E-05 0 1.60344E-05
A/G 15018 Ig-101 77 None 0.1907 None 0.979 N 0.518 0.269 0.34854441366 gnomAD-4.0.0 6.84892E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00059E-07 0 0
A/V 15018 Ig-101 77 rs72677221 0.222 -0.305 0.998 N 0.563 0.22 None gnomAD-2.1.1 7.74449E-04 None None None None N None 4.14E-05 5.66113E-03 None 0 0 None 0 None 0 7.85E-05 8.46501E-04
A/V 15018 Ig-101 77 rs72677221 0.222 -0.305 0.998 N 0.563 0.22 None gnomAD-3.1.2 4.08255E-04 None None None None N None 7.25E-05 3.67985E-03 0 0 1.95084E-04 None 0 0 2.94E-05 0 0
A/V 15018 Ig-101 77 rs72677221 0.222 -0.305 0.998 N 0.563 0.22 None 1000 genomes 1.79712E-03 None None None None N None 0 1.15E-02 None None 1E-03 0 None None None 0 None
A/V 15018 Ig-101 77 rs72677221 0.222 -0.305 0.998 N 0.563 0.22 None gnomAD-4.0.0 2.25177E-04 None None None None N None 5.33974E-05 4.9985E-03 None 0 8.97344E-05 None 0 0 3.30802E-05 2.19775E-05 2.40431E-04
S/P 15107 Ig-102 77 rs1236004974 0.8661 None 0.966 N 0.362 0.337 0.26547132957 gnomAD-4.0.0 1.59408E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8631E-06 0 0
S/T 15107 Ig-102 77 None 0.0966 None 0.051 N 0.217 0.12 0.134241683229 gnomAD-4.0.0 1.59408E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8631E-06 0 0
A/T 15196 Ig-103 77 rs372872095 0.0935 -0.784 0.214 N 0.195 0.089 None gnomAD-2.1.1 2.83E-05 None None None None N None 1.295E-04 0 None 0 0 None 1.63688E-04 None 0 0 0
A/T 15196 Ig-103 77 rs372872095 0.0935 -0.784 0.214 N 0.195 0.089 None gnomAD-3.1.2 1.98E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 1.47E-05 2.07039E-04 0
A/T 15196 Ig-103 77 rs372872095 0.0935 -0.784 0.214 N 0.195 0.089 None gnomAD-4.0.0 1.67462E-05 None None None None N None 1.33718E-05 1.67274E-05 None 0 0 None 0 0 9.32822E-06 1.4286E-04 1.60292E-05
H/R 15284 Ig-104 77 None 0.1272 None 0.101 N 0.249 0.123 0.209622950755 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/S 15467 Ig-106 77 rs1467418331 0.7076 -1.749 0.92 N 0.385 0.275 0.280987212366 gnomAD-2.1.1 1.62E-05 None None None None N None 0 1.16686E-04 None 0 0 None 0 None 0 0 0
R/S 15467 Ig-106 77 rs1467418331 0.7076 -1.749 0.92 N 0.385 0.275 0.280987212366 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/S 15467 Ig-106 77 rs1467418331 0.7076 -1.749 0.92 N 0.385 0.275 0.280987212366 gnomAD-4.0.0 4.3438E-06 None None None None N None 0 6.69098E-05 None 0 0 None 0 0 2.54518E-06 0 0
K/E 15556 Ig-107 77 rs747614888 0.4756 0.257 0.999 N 0.607 0.383 0.467585353272 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
K/E 15556 Ig-107 77 rs747614888 0.4756 0.257 0.999 N 0.607 0.383 0.467585353272 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/E 15556 Ig-107 77 rs747614888 0.4756 0.257 0.999 N 0.607 0.383 0.467585353272 gnomAD-4.0.0 8.68537E-06 None None None None N None 0 0 None 0 0 None 0 0 1.18767E-05 0 0
K/R 15556 Ig-107 77 None 0.1054 None 0.999 N 0.555 0.277 0.418964662724 gnomAD-4.0.0 1.59509E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86548E-06 0 0
K/T 15642 Ig-108 75 None 0.1601 None 0.733 N 0.453 0.305 0.339074221408 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
R/C 16040 Ig-109 73 rs774736458 0.1769 -0.034 0.807 N 0.223 0.271 0.470810165807 gnomAD-2.1.1 2.02E-05 None None None None I None 0 2.9E-05 None 0 0 None 1.30856E-04 None 0 0 0
R/C 16040 Ig-109 73 rs774736458 0.1769 -0.034 0.807 N 0.223 0.271 0.470810165807 gnomAD-3.1.2 2.64E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 2.95E-05 0 0
R/C 16040 Ig-109 73 rs774736458 0.1769 -0.034 0.807 N 0.223 0.271 0.470810165807 gnomAD-4.0.0 1.24044E-05 None None None None I None 2.67508E-05 1.67012E-05 None 0 2.23414E-05 None 0 0 6.78477E-06 8.78908E-05 0
R/H 16040 Ig-109 73 rs956699957 0.1122 -0.547 0.807 N 0.317 0.198 0.220303561663 gnomAD-2.1.1 1.21E-05 None None None None I None 0 5.81E-05 None 0 0 None 0 None 0 8.95E-06 0
R/H 16040 Ig-109 73 rs956699957 0.1122 -0.547 0.807 N 0.317 0.198 0.220303561663 gnomAD-3.1.2 2.63E-05 None None None None I None 0 6.57E-05 0 0 0 None 0 0 1.47E-05 2.06954E-04 4.78927E-04
R/H 16040 Ig-109 73 rs956699957 0.1122 -0.547 0.807 N 0.317 0.198 0.220303561663 gnomAD-4.0.0 1.42627E-05 None None None None I None 1.33454E-05 5.00751E-05 None 0 4.46887E-05 None 0 0 1.35693E-05 1.09849E-05 0
V/A 16336 Ig-110 75 None 0.1682 None 0.001 N 0.103 0.09 0.239305524855 gnomAD-4.0.0 2.40064E-06 None None None None I None 1.26695E-04 0 None 0 0 None 0 0 0 0 0
V/L 16336 Ig-110 75 None 0.2597 None 0.017 N 0.251 0.063 0.208000267992 gnomAD-4.0.0 1.5965E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43843E-05 0
K/N 17032 Ig-111 78 rs777424760 0.2799 0.224 0.001 N 0.249 0.172 0.146414634003 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
K/N 17032 Ig-111 78 rs777424760 0.2799 0.224 0.001 N 0.249 0.172 0.146414634003 gnomAD-4.0.0 3.18746E-06 None None None None I None 0 0 None 0 0 None 0 0 5.72607E-06 0 0
K/R 17032 Ig-111 78 None 0.0886 None None N 0.265 0.098 0.148003135375 gnomAD-4.0.0 4.80129E-06 None None None None I None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
D/E 17354 Ig-112 104 rs886055269 0.2096 None 0.051 N 0.272 0.06 0.252162846088 gnomAD-4.0.0 3.64904E-06 None None None None I None 0 3.25267E-05 None 0 0 None 0 0 0 1.86164E-05 0
D/V 17354 Ig-112 104 rs397517606 0.2059 0.267 0.669 N 0.369 0.292 0.521015664611 gnomAD-2.1.1 5.44E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.12E-05 0
D/Y 17354 Ig-112 104 None 0.2738 None 0.966 N 0.345 0.325 0.642701035604 gnomAD-4.0.0 1.82058E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.85625E-05 0
S/C 17749 Ig-113 73 rs2055164382 0.1548 None 0.987 N 0.305 0.562 0.614967603648 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/C 17749 Ig-113 73 rs2055164382 0.1548 None 0.987 N 0.305 0.562 0.614967603648 gnomAD-4.0.0 6.57722E-06 None None None None I None 2.41231E-05 0 None 0 0 None 0 0 0 0 0
S/N 17749 Ig-113 73 rs1553686153 0.1055 None 0.003 D 0.218 0.144 0.186928172975 gnomAD-4.0.0 6.84432E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15958E-05 0
S/T 17749 Ig-113 73 rs1553686153 0.0867 None 0.285 N 0.252 0.085 0.194818534648 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/T 17749 Ig-113 73 rs1553686153 0.0867 None 0.285 N 0.252 0.085 0.194818534648 gnomAD-4.0.0 4.33955E-06 None None None None I None 0 0 None 0 0 None 0 0 5.93516E-06 0 0
R/C 18050 Ig-114 83 rs55734111 0.4304 -0.05 1.0 N 0.439 0.401 None gnomAD-2.1.1 5.46575E-04 None None None None I None 0 0 None 0 7.58984E-03 None 3.34E-05 None 0 0 4.27594E-04
R/C 18050 Ig-114 83 rs55734111 0.4304 -0.05 1.0 N 0.439 0.401 None gnomAD-3.1.2 2.30272E-04 None None None None I None 0 1.31182E-04 0 0 6.04053E-03 None 0 0 1.47E-05 0 4.78927E-04
R/C 18050 Ig-114 83 rs55734111 0.4304 -0.05 1.0 N 0.439 0.401 None 1000 genomes 1.39776E-03 None None None None I None 0 0 None None 6.9E-03 0 None None None 0 None
R/C 18050 Ig-114 83 rs55734111 0.4304 -0.05 1.0 N 0.439 0.401 None gnomAD-4.0.0 1.64289E-04 None None None None I None 1.3388E-05 3.35706E-05 None 0 4.4525E-03 None 0 3.32336E-04 1.3611E-05 2.21327E-05 6.75393E-04
R/G 18050 Ig-114 83 rs55734111 0.6435 None 0.961 N 0.473 0.32 0.574160883478 gnomAD-4.0.0 2.7495E-06 None None None None I None 0 0 None 0 0 None 0 0 3.61149E-06 0 0
R/H 18050 Ig-114 83 rs774572776 0.2319 None 0.999 N 0.415 0.318 0.33340067248 gnomAD-4.0.0 9.6299E-06 None None None None I None 3.01768E-05 0 None 0 0 None 0 0 1.08391E-05 1.17275E-05 0
R/L 18050 Ig-114 83 rs774572776 0.5186 0.508 0.992 N 0.543 0.384 0.599314493506 gnomAD-2.1.1 4.1E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.05E-06 0
K/Q 18464 Ig-115 83 rs565100137 0.2038 -0.012 1.0 N 0.655 0.336 0.363158594168 gnomAD-2.1.1 3.28E-05 None None None None I None 0 0 None 0 0 None 2.74104E-04 None 0 0 0
K/Q 18464 Ig-115 83 rs565100137 0.2038 -0.012 1.0 N 0.655 0.336 0.363158594168 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 0 6.20604E-04 0
K/Q 18464 Ig-115 83 rs565100137 0.2038 -0.012 1.0 N 0.655 0.336 0.363158594168 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
K/Q 18464 Ig-115 83 rs565100137 0.2038 -0.012 1.0 N 0.655 0.336 0.363158594168 gnomAD-4.0.0 2.85925E-05 None None None None I None 0 0 None 0 0 None 0 0 1.27296E-05 3.34919E-04 1.60699E-05
N/D 18769 Ig-116 82 None 0.1524 None 0.961 N 0.432 0.29 0.280987212366 gnomAD-4.0.0 1.62984E-06 None None None None I None 0 0 None 0 0 None 0 0 2.92642E-06 0 0
E/D 19168 Ig-117 74 None 0.0873 None None N 0.285 0.099 0.168933306366 gnomAD-4.0.0 1.59371E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43563E-05 0
S/C 19464 Ig-118 74 None 0.1001 None 0.883 N 0.369 0.435 0.499727662827 gnomAD-4.0.0 6.00161E-06 None None None None I None 0 0 None 0 0 None 0 0 6.56251E-06 0 0
S/R 19464 Ig-118 74 None 0.5156 None 0.497 N 0.318 0.286 0.298403945805 gnomAD-4.0.0 5.47432E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29683E-06 0 1.65684E-05
S/T 19464 Ig-118 74 None 0.0691 None None N 0.186 0.146 0.280181792013 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
P/L 19862 Ig-119 73 rs16866406 0.148 0.094 0.008 D 0.387 0.19 None gnomAD-2.1.1 1.7341E-01 None None None None I None 7.16591E-02 1.47846E-01 None 1.73353E-01 4.3298E-01 None 2.57761E-01 None 1.51472E-01 1.45017E-01 1.60569E-01
P/L 19862 Ig-119 73 rs16866406 0.148 0.094 0.008 D 0.387 0.19 None gnomAD-3.1.2 1.42446E-01 None None None None I None 7.55679E-02 1.29443E-01 4.71366E-01 1.74352E-01 4.45762E-01 None 1.63206E-01 1.13924E-01 1.45726E-01 2.6495E-01 1.29187E-01
P/L 19862 Ig-119 73 rs16866406 0.148 0.094 0.008 D 0.387 0.19 None 1000 genomes 2.13059E-01 None None None None I None 6.66E-02 1.527E-01 None None 4.573E-01 1.392E-01 None None None 2.781E-01 None
P/L 19862 Ig-119 73 rs16866406 0.148 0.094 0.008 D 0.387 0.19 None gnomAD-4.0.0 1.53377E-01 None None None None I None 7.3695E-02 1.42795E-01 None 1.73981E-01 4.36539E-01 None 1.53056E-01 1.31692E-01 1.3915E-01 2.56485E-01 1.62679E-01
T/M 20849 Ig-122 81 rs372685222 0.0837 -0.051 0.537 N 0.311 0.11 None gnomAD-2.1.1 3.57E-05 None None None None I None 2.06629E-04 0 None 0 1.54735E-04 None 0 None 0 1.56E-05 0
T/M 20849 Ig-122 81 rs372685222 0.0837 -0.051 0.537 N 0.311 0.11 None gnomAD-3.1.2 8.55E-05 None None None None I None 1.68968E-04 6.56E-05 0 0 1.94024E-04 None 0 0 5.88E-05 0 0
T/M 20849 Ig-122 81 rs372685222 0.0837 -0.051 0.537 N 0.311 0.11 None gnomAD-4.0.0 2.47935E-05 None None None None I None 2.00304E-04 1.66795E-05 None 0 6.70301E-05 None 0 0 1.78023E-05 0 0
P/A 21251 Ig-123 75 None 0.0756 None 0.001 N 0.134 0.146 0.195762928549 gnomAD-4.0.0 6.85253E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00383E-07 0 0
P/S 21251 Ig-123 75 None 0.1191 None 0.003 N 0.133 0.129 0.165133752707 gnomAD-4.0.0 4.11152E-06 None None None None I None 0 0 None 0 0 None 0 0 5.4023E-06 0 0
P/T 21251 Ig-123 75 None 0.1009 None 0.002 N 0.172 0.18 0.243398259712 gnomAD-4.0.0 6.85253E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00383E-07 0 0
S/N 21544 Ig-124 76 rs1231941272 0.1537 0.179 0.999 D 0.478 0.352 0.437207349437 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
S/N 21544 Ig-124 76 rs1231941272 0.1537 0.179 0.999 D 0.478 0.352 0.437207349437 gnomAD-4.0.0 1.5953E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86572E-06 0 0
S/L 21941 Ig-125 76 None 0.0835 None None N 0.109 0.122 0.332386209738 gnomAD-4.0.0 7.13798E-07 None None None None I None 0 0 None 0 0 None 0 0 9.26911E-07 0 0
V/A 22628 Ig-127 69 None 0.0783 None None N 0.124 0.099 0.385249989106 gnomAD-4.0.0 4.10603E-06 None None None None I None 0 0 None 0 0 None 0 0 3.5984E-06 0 3.31411E-05
V/I 22628 Ig-127 69 rs775731759 0.0741 0.031 0.042 N 0.322 0.106 None gnomAD-2.1.1 7.15E-06 None None None None I None 8.27E-05 0 None 0 0 None 0 None 0 0 0
V/I 22628 Ig-127 69 rs775731759 0.0741 0.031 0.042 N 0.322 0.106 None gnomAD-3.1.2 3.29E-05 None None None None I None 1.20662E-04 0 0 0 0 None 0 0 0 0 0
V/I 22628 Ig-127 69 rs775731759 0.0741 0.031 0.042 N 0.322 0.106 None gnomAD-4.0.0 7.6901E-06 None None None None I None 1.01537E-04 0 None 0 0 None 0 0 0 0 0
P/A 23025 Ig-128 76 None 0.143 None 0.016 N 0.39 0.19 0.185906805712 gnomAD-4.0.0 6.84462E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15974E-05 0
P/L 23025 Ig-128 76 None 0.2663 None 0.898 N 0.594 0.399 0.5073929853 gnomAD-4.0.0 1.59262E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85997E-06 0 0
P/S 23025 Ig-128 76 None 0.2335 None 0.898 N 0.517 0.247 0.24896430686 gnomAD-4.0.0 6.84462E-07 None None None None I None 0 0 None 0 2.53036E-05 None 0 0 0 0 0
P/L 23420 Ig-129 76 rs776633672 0.0906 -0.018 0.029 N 0.375 0.143 0.481690325388 gnomAD-2.1.1 3.22E-05 None None None None N None 0 2.02793E-04 None 0 0 None 0 None 0 8.88E-06 0
P/L 23420 Ig-129 76 rs776633672 0.0906 -0.018 0.029 N 0.375 0.143 0.481690325388 gnomAD-3.1.2 1.97E-05 None None None None N None 0 1.96773E-04 0 0 0 None 0 0 0 0 0
P/L 23420 Ig-129 76 rs776633672 0.0906 -0.018 0.029 N 0.375 0.143 0.481690325388 gnomAD-4.0.0 1.17766E-05 None None None None N None 0 1.83437E-04 None 0 2.23055E-05 None 0 0 5.93413E-06 0 0
I/M 23711 Ig-130 75 rs1311167365 0.081 -0.556 0.005 N 0.327 0.102 0.239901079897 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
I/M 23711 Ig-130 75 rs1311167365 0.081 -0.556 0.005 N 0.327 0.102 0.239901079897 gnomAD-4.0.0 3.42189E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49792E-06 0 0
I/T 23711 Ig-130 75 rs752317656 0.0798 -0.331 None N 0.183 0.09 0.511275995344 gnomAD-2.1.1 5.64E-05 None None None None I None 0 1.16144E-04 None 0 0 None 9.81E-05 None 0 5.34E-05 1.66223E-04
I/T 23711 Ig-130 75 rs752317656 0.0798 -0.331 None N 0.183 0.09 0.511275995344 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
I/T 23711 Ig-130 75 rs752317656 0.0798 -0.331 None N 0.183 0.09 0.511275995344 gnomAD-4.0.0 2.10764E-05 None None None None I None 0 1.00087E-04 None 0 2.23784E-05 None 0 0 1.78028E-05 6.58906E-05 0
P/A 24107 Ig-131 79 None 0.1119 None 1.0 N 0.569 0.349 0.358134431457 gnomAD-4.0.0 8.40227E-06 None None None None I None 0 0 None 0 0 None 0 0 9.18753E-06 0 0
P/H 24107 Ig-131 79 None 0.4118 None 1.0 N 0.689 0.457 0.686132537371 gnomAD-4.0.0 6.8518E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00533E-07 0 0
P/T 24107 Ig-131 79 rs1709102867 0.135 None 1.0 N 0.627 0.386 0.521384976177 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 0 0 4.78927E-04
P/T 24107 Ig-131 79 rs1709102867 0.135 None 1.0 N 0.627 0.386 0.521384976177 gnomAD-4.0.0 6.57635E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 4.78927E-04
S/N 24504 Ig-132 74 None 0.128 None 0.979 N 0.382 0.316 0.303123707472 gnomAD-4.0.0 1.59252E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43447E-05 0
S/L 24793 Ig-133 78 rs766741890 0.0795 -0.033 0.213 N 0.387 0.373 None gnomAD-2.1.1 3.23E-05 None None None None I None 0 5.8E-05 None 0 0 None 0 None 0 5.35E-05 0
S/L 24793 Ig-133 78 rs766741890 0.0795 -0.033 0.213 N 0.387 0.373 None gnomAD-3.1.2 1.97E-05 None None None None I None 2.41E-05 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
S/L 24793 Ig-133 78 rs766741890 0.0795 -0.033 0.213 N 0.387 0.373 None gnomAD-4.0.0 1.79762E-05 None None None None I None 1.33576E-05 3.33467E-05 None 0 0 None 0 1.6469E-04 1.78039E-05 0 6.40615E-05
V/I 25189 Ig-134 79 rs757224932 0.0858 0.051 0.997 N 0.371 0.182 0.605332244828 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
V/I 25189 Ig-134 79 rs757224932 0.0858 0.051 0.997 N 0.371 0.182 0.605332244828 gnomAD-4.0.0 3.18431E-06 None None None None I None 0 0 None 0 0 None 0 2.41663E-04 0 0 3.02718E-05
S/G 25586 Ig-135 73 rs757243379 0.0751 -0.123 0.002 D 0.113 0.147 0.166414681773 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
S/G 25586 Ig-135 73 rs757243379 0.0751 -0.123 0.002 D 0.113 0.147 0.166414681773 gnomAD-4.0.0 5.47488E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19698E-06 0 0
S/I 25586 Ig-135 73 None 0.1019 None 0.896 D 0.383 0.372 0.66819093994 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/R 25586 Ig-135 73 rs757243379 0.3853 0.124 0.004 D 0.315 0.278 0.309839678437 gnomAD-2.1.1 2.86E-05 None None None None N None 0 0 None 0 4.111E-04 None 0 None 0 0 0
S/R 25586 Ig-135 73 rs757243379 0.3853 0.124 0.004 D 0.315 0.278 0.309839678437 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93125E-04 None 0 0 0 0 0
S/R 25586 Ig-135 73 rs757243379 0.3853 0.124 0.004 D 0.315 0.278 0.309839678437 gnomAD-4.0.0 2.47934E-06 None None None None N None 0 0 None 0 6.69075E-05 None 0 0 0 0 1.60149E-05
V/A 25875 Ig-136 78 rs370374073 0.0914 -0.145 0.003 N 0.101 0.085 None gnomAD-2.1.1 3.94E-05 None None None None I None 4.54846E-04 0 None 0 0 None 0 None 0 0 0
V/A 25875 Ig-136 78 rs370374073 0.0914 -0.145 0.003 N 0.101 0.085 None gnomAD-3.1.2 9.21E-05 None None None None I None 2.89603E-04 1.31148E-04 0 0 0 None 0 0 0 0 0
V/A 25875 Ig-136 78 rs370374073 0.0914 -0.145 0.003 N 0.101 0.085 None gnomAD-4.0.0 1.67358E-05 None None None None I None 2.93772E-04 3.336E-05 None 0 0 None 0 0 1.69553E-06 0 1.60174E-05
V/I 25875 Ig-136 78 rs763284241 0.0699 -0.061 0.007 N 0.249 0.153 0.364926071151 gnomAD-2.1.1 2.82E-05 None None None None I None 0 1.45062E-04 None 0 0 None 0 None 0 1.78E-05 0
V/I 25875 Ig-136 78 rs763284241 0.0699 -0.061 0.007 N 0.249 0.153 0.364926071151 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 25875 Ig-136 78 rs763284241 0.0699 -0.061 0.007 N 0.249 0.153 0.364926071151 gnomAD-4.0.0 5.57852E-06 None None None None I None 1.33526E-05 8.33834E-05 None 0 0 None 0 0 2.5433E-06 0 0
V/L 25875 Ig-136 78 rs763284241 0.1484 -0.047 0.309 N 0.35 0.118 0.4722639086 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.59E-05 None 0 None 0 0 0
V/L 25875 Ig-136 78 rs763284241 0.1484 -0.047 0.309 N 0.35 0.118 0.4722639086 gnomAD-4.0.0 6.84346E-07 None None None None I None 0 0 None 0 2.5227E-05 None 0 0 0 0 0
V/I 26271 Ig-137 79 rs748841355 0.1036 -0.104 0.773 N 0.395 0.121 0.493561785454 gnomAD-2.1.1 8.34E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.13E-06 1.74155E-04
V/I 26271 Ig-137 79 rs748841355 0.1036 -0.104 0.773 N 0.395 0.121 0.493561785454 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 26271 Ig-137 79 rs748841355 0.1036 -0.104 0.773 N 0.395 0.121 0.493561785454 gnomAD-4.0.0 5.17895E-06 None None None None I None 0 0 None 0 0 None 0 4.53721E-04 4.81851E-06 0 0
S/N 26957 Ig-139 78 None 0.1093 None 0.003 N 0.159 0.086 0.0954503805726 gnomAD-4.0.0 1.59154E-06 None None None None I None 0 2.28676E-05 None 0 0 None 0 0 0 0 0
V/A 27354 Ig-140 77 None 0.197 None 0.999 N 0.389 0.268 0.598468489023 gnomAD-4.0.0 6.84207E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.65656E-05
V/G 27354 Ig-140 77 rs368023868 0.4435 -0.256 1.0 N 0.691 0.492 None gnomAD-2.1.1 3.57E-05 None None None None I None 4.13326E-04 0 None 0 0 None 0 None 0 0 0
V/G 27354 Ig-140 77 rs368023868 0.4435 -0.256 1.0 N 0.691 0.492 None gnomAD-3.1.2 7.89E-05 None None None None I None 2.65482E-04 0 0 0 0 None 0 0 0 0 4.77555E-04
V/G 27354 Ig-140 77 rs368023868 0.4435 -0.256 1.0 N 0.691 0.492 None gnomAD-4.0.0 1.92112E-05 None None None None I None 3.73822E-04 0 None 0 0 None 0 0 0 0 4.80307E-05
V/I 27354 Ig-140 77 rs878854336 0.0978 -0.062 0.997 N 0.401 0.254 0.607789150232 gnomAD-2.1.1 1.21E-05 None None None None I None 0 8.69E-05 None 0 0 None 0 None 0 0 0
V/I 27354 Ig-140 77 rs878854336 0.0978 -0.062 0.997 N 0.401 0.254 0.607789150232 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 27354 Ig-140 77 rs878854336 0.0978 -0.062 0.997 N 0.401 0.254 0.607789150232 gnomAD-4.0.0 6.8162E-06 None None None None I None 0 1.5001E-04 None 0 0 None 0 0 1.69527E-06 0 0
N/S 27751 Ig-141 76 rs775527437 0.0625 0.372 0.007 N 0.097 0.111 0.0611884634855 gnomAD-2.1.1 8.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 1.66611E-04
N/S 27751 Ig-141 76 rs775527437 0.0625 0.372 0.007 N 0.097 0.111 0.0611884634855 gnomAD-4.0.0 4.77742E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57824E-06 0 0
V/A 28435 Ig-143 78 None 0.2345 None 0.025 N 0.322 0.203 None gnomAD-4.0.0 2.05282E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 4.97051E-05
V/A 28830 Ig-144 76 None 0.1049 None 0.012 N 0.289 0.159 0.427713192076 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 28830 Ig-144 76 None 0.0642 None None N 0.142 0.08 0.277317399466 gnomAD-4.0.0 1.59169E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85883E-06 0 0
S/P 29122 Ig-145 78 None 0.1897 None 0.928 N 0.379 0.484 0.345175991111 gnomAD-4.0.0 6.84266E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99413E-07 0 0
S/T 29122 Ig-145 78 rs1231787901 0.0671 0.127 0.645 N 0.354 0.15 0.244539031024 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
S/T 29122 Ig-145 78 rs1231787901 0.0671 0.127 0.645 N 0.354 0.15 0.244539031024 gnomAD-4.0.0 6.84266E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99413E-07 0 0
A/V 29518 Ig-146 75 None 0.1252 None 0.989 N 0.313 0.326 0.536287059136 gnomAD-4.0.0 3.60098E-06 None None None None I None 0 0 None 0 0 None 0 0 3.93752E-06 0 0
A/P 30209 Ig-148 78 None 0.2322 None 0.006 N 0.195 0.282 0.253726318573 gnomAD-4.0.0 1.59199E-06 None None None None I None 0 0 None 0 0 None 0 2.41546E-04 0 0 0
A/T 30209 Ig-148 78 None 0.0875 None 0.425 N 0.131 0.084 0.249502417897 gnomAD-4.0.0 1.59199E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85909E-06 0 0
A/V 30209 Ig-148 78 None 0.1106 None 0.006 N 0.165 0.179 0.353336612579 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/P 30604 Ig-149 73 rs1340152614 0.1356 -0.042 0.106 N 0.325 0.131 0.317667799068 gnomAD-2.1.1 4.04E-06 None None None None I None 0 2.91E-05 None 0 0 None 0 None 0 0 0
A/P 30604 Ig-149 73 rs1340152614 0.1356 -0.042 0.106 N 0.325 0.131 0.317667799068 gnomAD-4.0.0 1.59744E-06 None None None None I None 0 2.29169E-05 None 0 0 None 0 0 0 0 0
A/V 30604 Ig-149 73 rs1186406232 0.0706 None None N 0.091 0.145 0.139678290688 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/V 30604 Ig-149 73 rs1186406232 0.0706 None None N 0.091 0.145 0.139678290688 gnomAD-4.0.0 2.57073E-06 None None None None I None 1.69359E-05 0 None 0 0 None 0 0 0 0 2.85177E-05
N/D 31001 Ig-150 75 None 0.1121 None 0.928 N 0.447 0.237 0.195762928549 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/S 31001 Ig-150 75 rs1308531791 0.06 0.342 0.146 N 0.414 0.068 0.0846915920261 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
N/S 31001 Ig-150 75 rs1308531791 0.06 0.342 0.146 N 0.414 0.068 0.0846915920261 gnomAD-4.0.0 6.15761E-06 None None None None I None 0 0 None 0 0 None 0 0 8.095E-06 0 0
T/I 31293 Ig-151 76 None 0.1094 None 0.988 N 0.383 0.422 0.566228512615 gnomAD-4.0.0 1.59109E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85786E-06 0 0
A/D 31693 Ig-152 73 rs2288326 0.6674 -0.051 1.0 N 0.684 0.462 None gnomAD-2.1.1 1.75095E-04 None None None None I None 0 0 None 0 2.35608E-03 None 9.82E-05 None 0 0 0
A/D 31693 Ig-152 73 rs2288326 0.6674 -0.051 1.0 N 0.684 0.462 None gnomAD-3.1.2 1.38002E-04 None None None None I None 0 0 0 0 4.04624E-03 None 0 0 0 0 0
A/D 31693 Ig-152 73 rs2288326 0.6674 -0.051 1.0 N 0.684 0.462 None 1000 genomes 1.39776E-03 None None None None I None 0 0 None None 6.9E-03 0 None None None 0 None
A/D 31693 Ig-152 73 rs2288326 0.6674 -0.051 1.0 N 0.684 0.462 None gnomAD-4.0.0 1.95876E-04 None None None None I None 0 0 None 0 6.79802E-03 None 0 0 8.47948E-07 7.68859E-05 4.80246E-05
A/T 31693 Ig-152 73 rs928573760 0.1461 None 1.0 N 0.532 0.323 0.527809512145 gnomAD-4.0.0 1.16351E-05 None None None None I None 0 0 None 0 2.51927E-05 None 0 0 1.43966E-05 0 0
Q/R 32090 Ig-153 74 rs1205947497 0.0974 0.477 0.662 N 0.322 0.155 0.17948927462 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14863E-04 0 None 0 0 None 0 None 0 0 0
Q/R 32090 Ig-153 74 rs1205947497 0.0974 0.477 0.662 N 0.322 0.155 0.17948927462 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
Q/R 32090 Ig-153 74 rs1205947497 0.0974 0.477 0.662 N 0.322 0.155 0.17948927462 gnomAD-4.0.0 1.31423E-05 None None None None N None 4.82532E-05 0 None 0 0 None 0 0 0 0 0
V/I 32384 Ig-154 78 rs754763137 0.0754 0.016 0.334 N 0.373 0.099 0.495970961353 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/I 32384 Ig-154 78 rs754763137 0.0754 0.016 0.334 N 0.373 0.099 0.495970961353 gnomAD-4.0.0 3.18266E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8585E-06 1.43295E-05 0
K/E 32780 Ig-155 73 rs755409666 0.535 None 0.999 N 0.562 0.414 0.294918367191 gnomAD-4.0.0 3.42099E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49729E-06 0 0
E/K 33178 Ig-156 78 rs371017136 0.3151 0.8 0.812 N 0.507 0.341 None gnomAD-2.1.1 7.13E-06 None None None None I None 8.27E-05 0 None 0 0 None 0 None 0 0 0
E/K 33178 Ig-156 78 rs371017136 0.3151 0.8 0.812 N 0.507 0.341 None gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
E/K 33178 Ig-156 78 rs371017136 0.3151 0.8 0.812 N 0.507 0.341 None gnomAD-4.0.0 1.97122E-05 None None None None I None 7.23554E-05 0 None 0 0 None 0 0 0 0 0
R/K 33674 Ig-159 79 rs766217871 0.619 0.082 0.953 N 0.481 0.313 0.303453137403 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/K 33674 Ig-159 79 rs766217871 0.619 0.082 0.953 N 0.481 0.313 0.303453137403 gnomAD-4.0.0 1.59123E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
R/T 33674 Ig-159 79 rs766217871 0.9641 0.037 0.999 N 0.621 0.469 0.653912592101 gnomAD-2.1.1 4.02E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
R/T 33674 Ig-159 79 rs766217871 0.9641 0.037 0.999 N 0.621 0.469 0.653912592101 gnomAD-4.0.0 1.59123E-06 None None None None I None 5.65867E-05 0 None 0 0 None 0 0 0 0 0
D/E 34214 Ig-160 78 rs766760792 0.2035 -0.039 0.619 N 0.347 0.163 0.349429436713 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 2.22742E-04 None 0 None 0 0 0
D/E 34214 Ig-160 78 rs766760792 0.2035 -0.039 0.619 N 0.347 0.163 0.349429436713 gnomAD-4.0.0 9.54654E-06 None None None None N None 0 0 None 0 1.66362E-04 None 0 0 0 0 0
K/Q 34338 Ig-161 81 None 0.3044 None 0.994 N 0.587 0.427 0.377799810692 gnomAD-4.0.0 1.59099E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85767E-06 0 0
K/T 34338 Ig-161 81 None 0.3832 None 0.997 N 0.519 0.405 0.440498838766 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 34441 Ig-162 79 rs1166860726 0.098 None 0.09 N 0.425 0.121 0.15556083564 gnomAD-4.0.0 1.59097E-06 None None None None I None 0 0 None 0 2.77269E-05 None 0 0 0 0 0
T/P 34441 Ig-162 79 rs1166860726 0.2014 0.026 0.773 N 0.356 0.323 0.361360026772 gnomAD-2.1.1 3.18E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
E/D 35364 Ig-165 79 rs1407917338 0.1178 -0.233 0.434 N 0.304 0.084 0.209622950755 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/D 35364 Ig-165 79 rs1407917338 0.1178 -0.233 0.434 N 0.304 0.084 0.209622950755 gnomAD-4.0.0 6.56953E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
E/K 35364 Ig-165 79 None 0.1594 None 0.998 N 0.548 0.352 0.411665641125 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/A 35497 Ig-166 78 rs369870182 0.0745 -0.163 0.001 N 0.109 0.061 None gnomAD-2.1.1 7.43E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.59E-05 0
S/A 35497 Ig-166 78 rs369870182 0.0745 -0.163 0.001 N 0.109 0.061 None gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 0 None 0 0 5.88E-05 0 0
S/A 35497 Ig-166 78 rs369870182 0.0745 -0.163 0.001 N 0.109 0.061 None gnomAD-4.0.0 2.61938E-05 None None None None I None 0 0 None 0 0 None 0 0 3.48183E-05 0 1.60932E-05
S/L 35497 Ig-166 78 rs1688350064 0.1019 None 0.192 D 0.35 0.259 0.569526424754 gnomAD-4.0.0 4.82355E-06 None None None None I None 0 0 None 0 0 None 0 0 4.50645E-06 0 3.331E-05
F/V 35779 Ig-168 78 None 0.2534 None 0.425 N 0.275 0.241 0.45563089846 gnomAD-4.0.0 3.18219E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71585E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.