Structural position:

  • Domain Type: Ig
  • Aligned Position: 163
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
S/F 86 Ig-1 81 None 0.2923 None 1.0 N 0.609 0.5 0.634526825879 gnomAD-4.0.0 1.59046E-06 None None None -0.769(TCAP) I None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
S/Y 86 Ig-1 81 rs749985986 0.3017 -0.968 1.0 N 0.616 0.463 None gnomAD-2.1.1 3.98E-06 None None None -0.312(TCAP) I None 6.15E-05 0 None 0 0 None 0 None 0 0 0
S/Y 86 Ig-1 81 rs749985986 0.3017 -0.968 1.0 N 0.616 0.463 None gnomAD-3.1.2 6.57E-06 None None None -0.312(TCAP) I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/Y 86 Ig-1 81 rs749985986 0.3017 -0.968 1.0 N 0.616 0.463 None gnomAD-4.0.0 6.57082E-06 None None None -0.312(TCAP) I None 2.41313E-05 0 None 0 0 None 0 0 0 0 0
V/A 182 Ig-2 79 rs779093531 0.1617 -1.01 0.955 N 0.363 0.354 0.525767821325 gnomAD-2.1.1 7.96E-06 None None None -0.737(TCAP) I None 0 2.89E-05 None 0 0 None 0 None 0 8.8E-06 0
V/A 182 Ig-2 79 rs779093531 0.1617 -1.01 0.955 N 0.363 0.354 0.525767821325 gnomAD-3.1.2 6.57E-06 None None None -0.737(TCAP) I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 182 Ig-2 79 rs779093531 0.1617 -1.01 0.955 N 0.363 0.354 0.525767821325 gnomAD-4.0.0 6.19593E-06 None None None -0.737(TCAP) I None 0 3.33333E-05 None 0 0 None 0 0 6.77974E-06 0 0
V/G 182 Ig-2 79 None 0.3424 None 0.997 N 0.566 0.58 0.861525825586 gnomAD-4.0.0 6.84062E-07 None None None -0.686(TCAP) I None 2.98686E-05 0 None 0 0 None 0 0 0 0 0
V/I 182 Ig-2 79 rs370941860 0.1143 -0.56 0.987 N 0.457 0.238 None gnomAD-2.1.1 1.59E-05 None None None -0.963(TCAP) I None 6.15E-05 0 None 0 0 None 6.53E-05 None 0 8.8E-06 0
V/I 182 Ig-2 79 rs370941860 0.1143 -0.56 0.987 N 0.457 0.238 None gnomAD-3.1.2 1.97E-05 None None None -0.963(TCAP) I None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
V/I 182 Ig-2 79 rs370941860 0.1143 -0.56 0.987 N 0.457 0.238 None gnomAD-4.0.0 1.05326E-05 None None None -0.963(TCAP) I None 4.00416E-05 0 None 0 0 None 0 0 7.62704E-06 5.48944E-05 0
A/D 1021 Ig-3 79 None 0.7131 None 1.0 D 0.787 0.517 0.807495684022 gnomAD-4.0.0 1.59161E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85739E-06 0 0
A/S 1021 Ig-3 79 rs763746036 0.1706 -0.047 1.0 D 0.627 0.472 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/T 1021 Ig-3 79 rs763746036 0.2729 -0.137 1.0 D 0.697 0.419 0.436886369515 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.84E-06 0
A/T 1021 Ig-3 79 rs763746036 0.2729 -0.137 1.0 D 0.697 0.419 0.436886369515 gnomAD-4.0.0 1.59161E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8574E-06 0 0
H/R 1162 Ig-4 81 rs146887683 0.2634 0.219 0.006 N 0.319 0.107 None gnomAD-2.1.1 3.98E-06 None None None None I None 6.15E-05 0 None 0 0 None 0 None 0 0 0
H/R 1162 Ig-4 81 rs146887683 0.2634 0.219 0.006 N 0.319 0.107 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
H/R 1162 Ig-4 81 rs146887683 0.2634 0.219 0.006 N 0.319 0.107 None gnomAD-4.0.0 2.47837E-06 None None None None I None 0 0 None 0 0 None 0 0 3.38993E-06 0 0
K/E 1370 Ig-5 80 rs1453568535 0.7378 0.172 0.98 N 0.465 0.335 0.379366414296 gnomAD-2.1.1 7.98E-06 None None None None I None 0 0 None 1.98847E-04 0 None 0 None 0 0 0
K/E 1370 Ig-5 80 rs1453568535 0.7378 0.172 0.98 N 0.465 0.335 0.379366414296 gnomAD-4.0.0 3.18169E-06 None None None None I None 0 0 None 9.5338E-05 0 None 0 0 0 0 0
A/S 1536 Ig-6 80 rs879055295 0.3992 -0.057 1.0 D 0.637 0.448 0.401327265625 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
A/S 1536 Ig-6 80 rs879055295 0.3992 -0.057 1.0 D 0.637 0.448 0.401327265625 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/S 1536 Ig-6 80 rs879055295 0.3992 -0.057 1.0 D 0.637 0.448 0.401327265625 gnomAD-4.0.0 6.57333E-06 None None None None I None 2.41429E-05 0 None 0 0 None 0 0 0 0 0
A/T 1536 Ig-6 80 rs879055295 0.7861 -0.136 1.0 D 0.714 0.507 0.440288351245 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.84E-06 0
A/V 1536 Ig-6 80 None 0.7368 None 1.0 N 0.675 0.422 0.47290127212 gnomAD-4.0.0 9.57875E-06 None None None None I None 0 0 None 0 0 None 0 0 1.25913E-05 0 0
A/V 1636 Ig-7 81 None 0.3046 None 1.0 N 0.678 0.417 0.52730433808 gnomAD-4.0.0 1.59102E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43336E-05 0
Y/C 1783 Ig-8 81 None 0.7865 None 1.0 N 0.641 0.426 0.52891208781 gnomAD-4.0.0 1.60245E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
A/T 2157 Ig-10 80 None 0.5998 None 0.996 D 0.678 0.462 0.53782465974 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 1.94099E-04 0 None 0 0 0 0 0
A/V 2157 Ig-10 80 rs1217516150 0.4605 -0.61 0.884 N 0.498 0.286 0.473853734676 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
A/V 2157 Ig-10 80 rs1217516150 0.4605 -0.61 0.884 N 0.498 0.286 0.473853734676 gnomAD-4.0.0 9.57731E-06 None None None None N None 0 0 None 0 0 None 0 0 1.16908E-05 1.15931E-05 0
M/I 2610 Ig-15 78 rs56142888 0.1965 0.31 None N 0.117 0.104 0.337135696972 gnomAD-2.1.1 7.52578E-02 None None None None N None 1.12942E-02 2.37808E-01 None 4.85615E-02 2.00322E-01 None 1.84338E-02 None 5.3183E-02 4.43085E-02 6.37023E-02
M/I 2610 Ig-15 78 rs56142888 0.1965 0.31 None N 0.117 0.104 0.337135696972 gnomAD-3.1.2 4.98239E-02 None None None None N None 1.16027E-02 1.37979E-01 4.82456E-02 4.89631E-02 1.83725E-01 None 5.13014E-02 1.58228E-02 4.51805E-02 2.2144E-02 4.63228E-02
M/I 2610 Ig-15 78 rs56142888 0.1965 0.31 None N 0.117 0.104 0.337135696972 1000 genomes 7.54792E-02 None None None None N None 2.3E-03 1.715E-01 None None 1.905E-01 4.87E-02 None None None 1.53E-02 None
M/I 2610 Ig-15 78 rs56142888 0.1965 0.31 None N 0.117 0.104 0.337135696972 gnomAD-4.0.0 5.24191E-02 None None None None N None 1.05929E-02 2.0473E-01 None 4.7537E-02 1.88716E-01 None 5.40401E-02 1.6177E-02 4.49715E-02 1.97689E-02 5.11713E-02
M/L 2610 Ig-15 78 None 0.1339 None 0.001 N 0.125 0.11 0.32980341726 gnomAD-4.0.0 6.84169E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99361E-07 0 0
M/V 2610 Ig-15 78 rs1331698925 0.0705 0.143 None N 0.121 0.085 0.363944505237 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
M/V 2610 Ig-15 78 rs1331698925 0.0705 0.143 None N 0.121 0.085 0.363944505237 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
M/V 2610 Ig-15 78 rs1331698925 0.0705 0.143 None N 0.121 0.085 0.363944505237 gnomAD-4.0.0 1.85878E-06 None None None None N None 0 0 None 0 0 None 0 0 8.47509E-07 1.09815E-05 1.60005E-05
K/I 2697 Ig-16 77 None 0.2883 None 0.82 D 0.741 0.316 0.470730462751 gnomAD-4.0.0 6.84104E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99313E-07 0 0
K/R 2697 Ig-16 77 None 0.0908 None 0.565 N 0.663 0.155 0.344251166708 gnomAD-4.0.0 6.84104E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99313E-07 0 0
G/R 2785 Ig-17 79 None 0.448 None 0.984 D 0.679 0.583 0.817025628476 gnomAD-4.0.0 1.59056E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
Q/L 2959 Ig-19 78 rs2091182281 0.2273 None 0.425 N 0.539 0.279 0.432716982437 gnomAD-4.0.0 3.18334E-06 None None None None N None 0 0 None 0 5.55093E-05 None 0 0 0 0 0
V/M 3135 Ig-21 78 rs557922344 0.0585 -0.447 0.01 N 0.264 0.114 0.242244723065 gnomAD-2.1.1 7.97E-06 None None None None N None 0 0 None 0 1.09016E-04 None 0 None 0 0 0
V/M 3135 Ig-21 78 rs557922344 0.0585 -0.447 0.01 N 0.264 0.114 0.242244723065 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 1.92382E-04 None 0 0 0 2.06954E-04 0
V/M 3135 Ig-21 78 rs557922344 0.0585 -0.447 0.01 N 0.264 0.114 0.242244723065 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 1E-03 0 None None None 1E-03 None
V/M 3135 Ig-21 78 rs557922344 0.0585 -0.447 0.01 N 0.264 0.114 0.242244723065 gnomAD-4.0.0 7.43435E-06 None None None None N None 2.6656E-05 0 None 0 6.68628E-05 None 0 0 2.54239E-06 3.29359E-05 1.59974E-05
Y/C 3317 Ig-23 79 rs768476150 0.3456 0.364 0.999 D 0.605 0.554 0.614776886339 gnomAD-2.1.1 1.99E-05 None None None None I None 0 2.89E-05 None 0 0 None 0 None 0 3.54E-05 0
Y/C 3317 Ig-23 79 rs768476150 0.3456 0.364 0.999 D 0.605 0.554 0.614776886339 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 4.77555E-04
Y/C 3317 Ig-23 79 rs768476150 0.3456 0.364 0.999 D 0.605 0.554 0.614776886339 gnomAD-4.0.0 1.28053E-05 None None None None I None 0 1.69434E-05 None 0 2.42377E-05 None 0 0 1.67417E-05 0 2.84236E-05
V/E 3422 Ig-24 78 None 0.3758 None 0.055 N 0.572 0.289 0.653172182626 gnomAD-4.0.0 6.84123E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99345E-07 0 0
V/G 3422 Ig-24 78 rs1280394561 0.2945 -0.285 None N 0.453 0.233 0.624628272354 gnomAD-2.1.1 3.98E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/G 3422 Ig-24 78 rs1280394561 0.2945 -0.285 None N 0.453 0.233 0.624628272354 gnomAD-4.0.0 6.84123E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15937E-05 0
V/L 3422 Ig-24 78 None 0.2702 None None N 0.225 0.084 0.159798565429 gnomAD-4.0.0 4.80129E-06 None None None None I None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
A/V 3545 Ig-25 81 rs1319587121 0.1498 -0.031 None None None 0.123 None gnomAD-2.1.1 4.08E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.01E-06 0
A/V 3545 Ig-25 81 rs1319587121 0.1498 -0.031 None None None 0.123 None gnomAD-4.0.0 4.84287E-06 None None None None I None 0 0 None 0 0 None 0 0 8.72966E-06 0 0
C/F 3738 Ig-26 79 rs1216398376 0.0751 -0.744 None None None 0.13 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
C/F 3738 Ig-26 79 rs1216398376 0.0751 -0.744 None None None 0.13 None gnomAD-4.0.0 2.05309E-06 None None None None I None 0 0 None 0 2.51991E-05 None 0 0 1.79935E-06 0 0
C/Y 3738 Ig-26 79 None 0.0638 None None None None 0.131 None gnomAD-4.0.0 2.05309E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69902E-06 0 0
Y/C 3898 Ig-27 79 rs747933911 0.112 0.324 0.987 N 0.507 0.339 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
Y/C 3898 Ig-27 79 rs747933911 0.112 0.324 0.987 N 0.507 0.339 None gnomAD-4.0.0 1.59116E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85801E-06 0 0
Y/D 3898 Ig-27 79 rs1553941743 0.1689 None 0.326 N 0.493 0.324 None gnomAD-4.0.0 4.77348E-06 None None None None I None 0 0 None 0 0 None 0 0 8.57403E-06 0 0
L/F 4017 Ig-28 80 None 0.0805 None None N 0.229 0.118 None gnomAD-4.0.0 2.05325E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69831E-06 0 0
L/S 4017 Ig-28 80 rs1487515911 0.1705 -0.092 0.055 N 0.533 0.136 None gnomAD-2.1.1 4.03E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
L/S 4017 Ig-28 80 rs1487515911 0.1705 -0.092 0.055 N 0.533 0.136 None gnomAD-4.0.0 1.5923E-06 None None None None I None 5.65291E-05 0 None 0 0 None 0 0 0 0 0
L/V 4017 Ig-28 80 rs367635055 0.1067 0.014 0.012 N 0.355 0.152 None gnomAD-2.1.1 6.8E-05 None None None None I None 7.85449E-04 0 None 0 0 None 0 None 0 0 0
L/V 4017 Ig-28 80 rs367635055 0.1067 0.014 0.012 N 0.355 0.152 None gnomAD-3.1.2 1.64264E-04 None None None None I None 6.02991E-04 0 0 0 0 None 0 0 0 0 0
L/V 4017 Ig-28 80 rs367635055 0.1067 0.014 0.012 N 0.355 0.152 None gnomAD-4.0.0 2.41737E-05 None None None None I None 5.07099E-04 0 None 0 0 None 0 0 0 0 1.60123E-05
Y/H 4778 Ig-30 79 None 0.1478 None None N 0.242 0.129 0.209622950755 gnomAD-4.0.0 1.59141E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85851E-06 0 0
F/L 4873 Ig-31 79 None 0.9615 None 0.704 N 0.303 0.262 0.304108284078 gnomAD-4.0.0 1.59142E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85816E-06 0 0
V/I 5060 Ig-33 80 rs72648929 0.0902 -0.015 0.915 N 0.379 0.208 None gnomAD-2.1.1 2.50423E-03 None None None None I None 0 0 None 0 3.43785E-02 None 2.61883E-04 None 0 8.6E-05 1.54712E-03
V/I 5060 Ig-33 80 rs72648929 0.0902 -0.015 0.915 N 0.379 0.208 None gnomAD-3.1.2 9.66101E-04 None None None None I None 2.41E-05 0 0 0 2.58189E-02 None 0 0 8.82E-05 8.28157E-04 9.56023E-04
V/I 5060 Ig-33 80 rs72648929 0.0902 -0.015 0.915 N 0.379 0.208 None 1000 genomes 4.39297E-03 None None None None I None 0 0 None None 2.08E-02 1E-03 None None None 0 None
V/I 5060 Ig-33 80 rs72648929 0.0902 -0.015 0.915 N 0.379 0.208 None gnomAD-4.0.0 9.22373E-04 None None None None I None 1.33269E-05 0 None 0 2.89803E-02 None 0 1.6518E-04 5.85098E-05 2.96606E-04 1.44069E-03
V/L 5060 Ig-33 80 rs72648929 0.3489 -0.002 0.708 N 0.386 0.236 None gnomAD-2.1.1 3.20085E-03 None None None None I None 1.65385E-04 6.50784E-04 None 8.80929E-03 0 None 7.82375E-03 None 1.60334E-03 3.72819E-03 3.09423E-03
V/L 5060 Ig-33 80 rs72648929 0.3489 -0.002 0.708 N 0.386 0.236 None gnomAD-3.1.2 2.35282E-03 None None None None I None 4.34174E-04 5.89623E-04 0 9.51009E-03 3.85356E-04 None 1.88395E-03 0 3.35245E-03 8.90269E-03 2.39006E-03
V/L 5060 Ig-33 80 rs72648929 0.3489 -0.002 0.708 N 0.386 0.236 None 1000 genomes 3.39457E-03 None None None None I None 0 1.4E-03 None None 0 4E-03 None None None 1.23E-02 None
V/L 5060 Ig-33 80 rs72648929 0.3489 -0.002 0.708 N 0.386 0.236 None gnomAD-4.0.0 3.17871E-03 None None None None I None 4.66443E-04 6.66756E-04 None 9.69791E-03 1.56048E-04 None 1.40638E-03 9.41526E-03 3.08998E-03 8.45875E-03 3.16952E-03
V/D 5153 Ig-34 79 None 0.8542 None 1.0 D 0.741 0.686 0.895487556599 gnomAD-4.0.0 1.37438E-06 None None None None I None 0 0 None 0 0 None 0 0 9.02887E-07 1.16981E-05 0
V/L 5339 Ig-36 79 rs2080875658 0.4813 None 0.489 D 0.472 0.261 0.376216005999 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
V/M 5435 Ig-37 79 rs72648937 0.1528 -0.297 0.086 N 0.27 0.13 None gnomAD-2.1.1 5.98837E-03 None None None None I None 6.16008E-03 2.0135E-03 None 1.04793E-02 1.03061E-04 None 3.60443E-03 None 3.68915E-03 8.68303E-03 4.64789E-03
V/M 5435 Ig-37 79 rs72648937 0.1528 -0.297 0.086 N 0.27 0.13 None gnomAD-3.1.2 6.49248E-03 None None None None I None 5.42639E-03 2.22601E-03 0 9.79827E-03 3.85654E-04 None 3.29691E-03 0 9.24728E-03 2.27932E-03 8.60421E-03
V/M 5435 Ig-37 79 rs72648937 0.1528 -0.297 0.086 N 0.27 0.13 None 1000 genomes 3.59425E-03 None None None None I None 5.3E-03 0 None None 0 1.09E-02 None None None 0 None
V/M 5435 Ig-37 79 rs72648937 0.1528 -0.297 0.086 N 0.27 0.13 None gnomAD-4.0.0 8.05303E-03 None None None None I None 6.16922E-03 2.31752E-03 None 1.08189E-02 6.70002E-05 None 3.95448E-03 2.31252E-03 9.30972E-03 3.71445E-03 7.70044E-03
A/T 5528 Ig-38 79 rs185753307 0.1772 -0.362 1.0 N 0.709 0.415 None gnomAD-2.1.1 1.79E-05 None None None None I None 8.27E-05 0 None 0 0 None 0 None 0 2.35E-05 0
A/T 5528 Ig-38 79 rs185753307 0.1772 -0.362 1.0 N 0.709 0.415 None gnomAD-3.1.2 3.29E-05 None None None None I None 2.41E-05 6.55E-05 0 0 0 None 0 0 4.41E-05 0 0
A/T 5528 Ig-38 79 rs185753307 0.1772 -0.362 1.0 N 0.709 0.415 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
A/T 5528 Ig-38 79 rs185753307 0.1772 -0.362 1.0 N 0.709 0.415 None gnomAD-4.0.0 1.42623E-05 None None None None I None 2.66788E-05 3.33723E-05 None 6.76865E-05 0 None 1.56255E-05 0 1.35697E-05 0 0
A/V 5528 Ig-38 79 None 0.1341 None 1.0 N 0.676 0.416 0.501247319706 gnomAD-4.0.0 1.59402E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86359E-06 0 0
A/S 5622 Ig-39 80 rs1212075565 0.1694 0.051 0.998 N 0.65 0.419 0.394230963961 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.66556E-04
A/S 5622 Ig-39 80 rs1212075565 0.1694 0.051 0.998 N 0.65 0.419 0.394230963961 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 1.92604E-04 None 9.43E-05 0 0 0 0
A/S 5622 Ig-39 80 rs1212075565 0.1694 0.051 0.998 N 0.65 0.419 0.394230963961 gnomAD-4.0.0 6.8213E-06 None None None None I None 0 0 None 0 2.22896E-05 None 1.40665E-04 0 8.48163E-07 0 0
A/V 5622 Ig-39 80 None 0.1908 None 0.884 N 0.491 0.271 0.392239652056 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 5715 Ig-40 79 rs1279938466 0.219 None 0.999 N 0.586 0.373 0.46289702323 gnomAD-4.0.0 6.84394E-07 None None None None I None 2.98793E-05 0 None 0 0 None 0 0 0 0 0
V/E 5715 Ig-40 79 None 0.7249 None 1.0 N 0.709 0.54 0.830966879155 gnomAD-4.0.0 4.10637E-06 None None None None I None 0 0 None 0 0 None 0 0 5.3983E-06 0 0
V/M 5715 Ig-40 79 None 0.3805 None 1.0 N 0.737 0.411 0.534814951121 gnomAD-4.0.0 2.05297E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79919E-06 0 1.65684E-05
A/S 5808 Ig-41 79 None 0.231 None 1.0 N 0.63 0.355 0.378498632473 gnomAD-4.0.0 1.59127E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85838E-06 0 0
A/V 5808 Ig-41 79 rs1409068952 0.3387 None 1.0 D 0.669 0.371 0.449088463789 gnomAD-4.0.0 1.36843E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79896E-06 0 0
A/T 5997 Ig-43 79 rs72648946 0.716 -0.225 0.997 N 0.703 0.441 None gnomAD-2.1.1 1.80344E-03 None None None None I None 1.93468E-02 7.64007E-04 None 0 0 None 0 None 0 5.47E-05 4.22178E-04
A/T 5997 Ig-43 79 rs72648946 0.716 -0.225 0.997 N 0.703 0.441 None gnomAD-3.1.2 5.2981E-03 None None None None I None 1.86052E-02 1.4413E-03 0 0 0 None 0 0 8.82E-05 0 3.34928E-03
A/T 5997 Ig-43 79 rs72648946 0.716 -0.225 0.997 N 0.703 0.441 None 1000 genomes 3.79393E-03 None None None None I None 1.44E-02 0 None None 0 0 None None None 0 None
A/T 5997 Ig-43 79 rs72648946 0.716 -0.225 0.997 N 0.703 0.441 None gnomAD-4.0.0 9.95458E-04 None None None None I None 1.9198E-02 1.06688E-03 None 0 0 None 0 1.65289E-04 3.05231E-05 0 1.04077E-03
A/S 6184 Ig-45 80 None 0.1364 None 1.0 N 0.634 0.415 0.411133732114 gnomAD-4.0.0 1.36848E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79903E-06 0 0
A/T 6184 Ig-45 80 rs72648947 0.1594 -0.152 1.0 D 0.711 0.423 None gnomAD-2.1.1 3.82553E-04 None None None None I None 1.24069E-04 6.22383E-04 None 0 0 None 1.63399E-04 None 1.19894E-04 5.64254E-04 2.81057E-04
A/T 6184 Ig-45 80 rs72648947 0.1594 -0.152 1.0 D 0.711 0.423 None gnomAD-3.1.2 4.53607E-04 None None None None I None 4.83E-05 2.03199E-03 0 0 0 None 9.43E-05 6.32911E-03 4.85266E-04 0 0
A/T 6184 Ig-45 80 rs72648947 0.1594 -0.152 1.0 D 0.711 0.423 None gnomAD-4.0.0 3.69336E-04 None None None None I None 1.06644E-04 9.0003E-04 None 0 2.22886E-05 None 2.65584E-04 3.63396E-03 3.83993E-04 1.64694E-04 4.16173E-04
F/L 6463 Ig-48 79 rs267599062 0.8749 -0.092 0.704 N 0.296 0.197 0.265010934533 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
F/L 6463 Ig-48 79 rs267599062 0.8749 -0.092 0.704 N 0.296 0.197 0.265010934533 gnomAD-4.0.0 1.23278E-05 None None None None I None 0 0 None 0 0 None 0 0 1.53022E-05 0 1.65843E-05
A/P 6559 Ig-49 79 None 0.8728 None 0.056 D 0.441 0.475 0.416833835346 gnomAD-4.0.0 1.61547E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.05998E-05
A/S 6746 Ig-51 80 rs202108224 0.1527 -0.151 0.997 N 0.649 0.389 0.345859378078 gnomAD-2.1.1 4.11E-06 None None None None I None 0 2.99E-05 None 0 0 None 0 None 0 0 0
A/S 6746 Ig-51 80 rs202108224 0.1527 -0.151 0.997 N 0.649 0.389 0.345859378078 gnomAD-4.0.0 1.3843E-06 None None None None I None 0 4.56684E-05 None 0 0 None 0 0 0 0 0
A/T 6746 Ig-51 80 rs202108224 0.2277 -0.236 1.0 D 0.675 0.436 None gnomAD-2.1.1 3.27921E-04 None None None None I None 3.25733E-03 2.03963E-04 None 0 0 None 6.8E-05 None 4.03E-05 1.59E-05 0
A/T 6746 Ig-51 80 rs202108224 0.2277 -0.236 1.0 D 0.675 0.436 None gnomAD-3.1.2 7.23265E-04 None None None None I None 2.50989E-03 1.96696E-04 0 0 0 None 0 0 1.47E-05 2.06954E-04 4.78469E-04
A/T 6746 Ig-51 80 rs202108224 0.2277 -0.236 1.0 D 0.675 0.436 None 1000 genomes 1.99681E-04 None None None None I None 0 1.4E-03 None None 0 0 None None None 0 None
A/T 6746 Ig-51 80 rs202108224 0.2277 -0.236 1.0 D 0.675 0.436 None gnomAD-4.0.0 1.459E-04 None None None None I None 2.55984E-03 1.18511E-04 None 0 2.2485E-05 None 0 0 1.8815E-05 5.68169E-05 1.13426E-04
V/L 6839 Ig-52 79 None 0.6691 None 0.673 N 0.567 0.294 0.398727352345 gnomAD-4.0.0 1.60088E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.03638E-05
G/A 6933 Ig-53 80 rs200118743 0.067 0.21 0.001 N 0.295 0.218 None gnomAD-2.1.1 6.08512E-04 None None None None I None 2.09556E-04 3.47786E-04 None 0 0 None 0 None 7.43986E-04 1.03358E-03 2.92398E-04
G/A 6933 Ig-53 80 rs200118743 0.067 0.21 0.001 N 0.295 0.218 None gnomAD-3.1.2 6.04452E-04 None None None None I None 1.44718E-04 1.96438E-04 0 0 0 None 7.52445E-04 0 1.08792E-03 0 4.78469E-04
G/A 6933 Ig-53 80 rs200118743 0.067 0.21 0.001 N 0.295 0.218 None 1000 genomes 5.99042E-04 None None None None I None 0 0 None None 0 3E-03 None None None 0 None
G/A 6933 Ig-53 80 rs200118743 0.067 0.21 0.001 N 0.295 0.218 None gnomAD-4.0.0 1.2351E-03 None None None None I None 1.46859E-04 4.38227E-04 None 0 0 None 7.72481E-04 0 1.56577E-03 0 9.02382E-04
G/V 6933 Ig-53 80 None 0.1658 None 0.379 N 0.548 0.243 0.548865971634 gnomAD-4.0.0 6.8928E-07 None None None None I None 0 0 None 0 0 None 0 0 9.0428E-07 0 0
V/A 7026 Ig-54 79 None 0.2181 None 0.543 N 0.393 0.294 0.406394481233 gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
A/S 7122 Ig-55 79 rs201394117 0.1561 -0.126 0.999 N 0.647 0.421 0.440288351245 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
A/S 7122 Ig-55 79 rs201394117 0.1561 -0.126 0.999 N 0.647 0.421 0.440288351245 gnomAD-4.0.0 1.36925E-06 None None None None I None 0 0 None 3.83289E-05 0 None 0 0 8.99954E-07 0 0
A/T 7122 Ig-55 79 rs201394117 0.2379 -0.192 1.0 D 0.697 0.483 None gnomAD-2.1.1 4.72627E-04 None None None None I None 1.24039E-04 5.67E-05 None 0 1.02501E-04 None 3.28E-05 None 9.22287E-04 7.45308E-04 8.46501E-04
A/T 7122 Ig-55 79 rs201394117 0.2379 -0.192 1.0 D 0.697 0.483 None gnomAD-3.1.2 3.944E-04 None None None None I None 2.41E-05 1.31027E-04 0 0 1.92753E-04 None 7.53864E-04 0 7.05799E-04 0 0
A/T 7122 Ig-55 79 rs201394117 0.2379 -0.192 1.0 D 0.697 0.483 None gnomAD-4.0.0 3.57742E-04 None None None None I None 4.00011E-05 6.67067E-05 None 3.38272E-05 2.22955E-05 None 9.37734E-04 1.65453E-04 4.09611E-04 7.69535E-05 2.72226E-04
A/P 7215 Ig-56 79 None 0.9039 None 1.0 D 0.659 0.576 0.620251207734 gnomAD-4.0.0 6.84525E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.65761E-05
A/S 7215 Ig-56 79 rs767445301 0.1412 None 0.999 N 0.594 0.466 0.463328977263 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/S 7215 Ig-56 79 rs767445301 0.1412 None 0.999 N 0.594 0.466 0.463328977263 gnomAD-4.0.0 2.47991E-06 None None None None I None 0 0 None 0 0 None 0 0 3.39127E-06 0 0
A/T 7215 Ig-56 79 rs767445301 0.1673 -0.13 0.999 D 0.602 0.465 0.504113619024 gnomAD-2.1.1 1.21E-05 None None None None I None 0 2.91E-05 None 0 0 None 3.28E-05 None 0 0 1.66778E-04
A/T 7215 Ig-56 79 rs767445301 0.1673 -0.13 0.999 D 0.602 0.465 0.504113619024 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
A/T 7215 Ig-56 79 rs767445301 0.1673 -0.13 0.999 D 0.602 0.465 0.504113619024 gnomAD-4.0.0 8.67968E-06 None None None None I None 0 1.66978E-05 None 0 0 None 0 0 8.47818E-06 3.29765E-05 0
A/V 7215 Ig-56 79 rs759533714 0.1467 -0.019 0.767 N 0.399 0.242 0.412328234245 gnomAD-2.1.1 2.02E-05 None None None None I None 0 2.91E-05 None 0 1.6803E-04 None 0 None 0 8.91E-06 0
A/V 7215 Ig-56 79 rs759533714 0.1467 -0.019 0.767 N 0.399 0.242 0.412328234245 gnomAD-4.0.0 1.43342E-05 None None None None I None 0 2.28969E-05 None 0 1.38935E-04 None 0 0 8.5803E-06 0 0
L/F 7497 Ig-59 79 None 0.1115 None 0.933 N 0.404 0.233 0.416075642716 gnomAD-4.0.0 1.60301E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.45319E-05 0
V/A 7593 Ig-60 79 rs758335261 0.0974 0.002 0.011 N 0.248 0.125 0.306695030598 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
V/A 7593 Ig-60 79 rs758335261 0.0974 0.002 0.011 N 0.248 0.125 0.306695030598 gnomAD-4.0.0 1.59349E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86213E-06 0 0
V/I 7687 Ig-61 80 None 0.0805 None 0.78 N 0.382 0.22 0.562540394707 gnomAD-4.0.0 1.62139E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.44818E-05 0
V/E 7780 Ig-62 79 None 0.8094 None 0.997 N 0.701 0.57 0.839276590097 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
V/L 7780 Ig-62 79 rs1220083902 0.664 -0.038 0.932 N 0.597 0.294 0.482061804652 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
V/L 7780 Ig-62 79 rs1220083902 0.664 -0.038 0.932 N 0.597 0.294 0.482061804652 gnomAD-4.0.0 1.592E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85963E-06 0 0
V/M 7780 Ig-62 79 None 0.4272 None 0.999 N 0.733 0.453 0.547681404787 gnomAD-4.0.0 1.592E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85963E-06 0 0
A/V 7874 Ig-63 80 None 0.347 None 0.143 N 0.409 0.172 0.362960570912 gnomAD-4.0.0 3.18752E-06 None None None None I None 0 0 None 0 2.77793E-05 None 0 0 2.86282E-06 0 0
A/P 8156 Ig-66 79 None 0.9367 None 1.0 D 0.747 0.563 0.616597772999 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/D 8249 Ig-67 79 None 0.7446 None 0.994 N 0.634 0.442 0.562990493178 gnomAD-4.0.0 1.59151E-06 None None None None I None 0 0 None 0 2.773E-05 None 0 0 0 0 0
A/S 8249 Ig-67 79 None 0.169 None 0.798 D 0.377 0.261 0.317667799068 gnomAD-4.0.0 6.84258E-07 None None None None I None 0 0 None 0 0 None 1.87322E-05 0 0 0 0
A/T 8249 Ig-67 79 None 0.2543 None 0.978 D 0.534 0.434 0.408714661073 gnomAD-4.0.0 6.84258E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15958E-05 0
A/S 8534 Ig-70 79 rs779163897 0.1185 -0.154 0.85 N 0.405 0.326 0.352048277211 gnomAD-2.1.1 2.82E-05 None None None None I None 0 1.74135E-04 None 0 0 None 0 None 0 8.9E-06 0
A/S 8534 Ig-70 79 rs779163897 0.1185 -0.154 0.85 N 0.405 0.326 0.352048277211 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
A/S 8534 Ig-70 79 rs779163897 0.1185 -0.154 0.85 N 0.405 0.326 0.352048277211 gnomAD-4.0.0 1.73567E-05 None None None None I None 0 1.16725E-04 None 0 0 None 0 0 1.78043E-05 0 0
A/T 8534 Ig-70 79 rs779163897 0.1088 -0.223 0.982 N 0.385 0.354 0.383256108077 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.66611E-04
A/T 8534 Ig-70 79 rs779163897 0.1088 -0.223 0.982 N 0.385 0.354 0.383256108077 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 8534 Ig-70 79 rs779163897 0.1088 -0.223 0.982 N 0.385 0.354 0.383256108077 gnomAD-4.0.0 2.29356E-05 None None None None I None 0 0 None 0 0 None 0 1.64636E-04 3.05217E-05 0 0
A/V 8628 Ig-71 80 None 0.1072 None 0.682 N 0.495 0.25 0.434272847907 gnomAD-4.0.0 1.59257E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86157E-06 0 0
V/M 8721 Ig-72 79 rs777730788 0.3244 -0.331 0.999 N 0.67 0.432 0.641123051583 gnomAD-2.1.1 2.29894E-04 None None None None I None 0 0 None 0 0 None 1.84053E-03 None 0 8.92E-06 0
V/M 8721 Ig-72 79 rs777730788 0.3244 -0.331 0.999 N 0.67 0.432 0.641123051583 gnomAD-3.1.2 5.26E-05 None None None None I None 0 0 0 0 0 None 0 0 0 1.65632E-03 0
V/M 8721 Ig-72 79 rs777730788 0.3244 -0.331 0.999 N 0.67 0.432 0.641123051583 gnomAD-4.0.0 1.08498E-04 None None None None I None 0 0 None 0 0 None 0 0 1.69597E-06 1.84774E-03 8.00846E-05
A/G 8815 Ig-73 80 rs1168744166 0.1447 -0.041 0.998 N 0.606 0.471 0.442875378763 gnomAD-2.1.1 7.15E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.56E-05 0
A/G 8815 Ig-73 80 rs1168744166 0.1447 -0.041 0.998 N 0.606 0.471 0.442875378763 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 4.77555E-04
A/G 8815 Ig-73 80 rs1168744166 0.1447 -0.041 0.998 N 0.606 0.471 0.442875378763 gnomAD-4.0.0 8.96895E-06 None None None None I None 1.68856E-05 0 None 0 0 None 0 0 9.57648E-06 0 5.68408E-05
A/V 8815 Ig-73 80 rs1168744166 0.1729 0.004 1.0 N 0.678 0.404 0.45235992198 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
A/V 8815 Ig-73 80 rs1168744166 0.1729 0.004 1.0 N 0.678 0.404 0.45235992198 gnomAD-4.0.0 3.18348E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.8659E-05 0
V/I 8908 Ig-74 79 None 0.0948 None 0.98 N 0.463 0.273 0.40146981186 gnomAD-4.0.0 1.59176E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85915E-06 0 0
A/T 9004 Ig-75 79 None 0.2682 None 0.892 N 0.517 0.341 0.326881540566 gnomAD-4.0.0 2.05278E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69853E-06 0 0
V/M 9283 Ig-78 79 rs727504515 0.2402 -0.304 0.999 D 0.568 0.334 0.419713421852 gnomAD-2.1.1 1.66155E-04 None None None None I None 0 6.99545E-04 None 0 5.57E-05 None 4.64807E-04 None 0 1.79E-05 0
V/M 9283 Ig-78 79 rs727504515 0.2402 -0.304 0.999 D 0.568 0.334 0.419713421852 gnomAD-3.1.2 6.57E-05 None None None None I None 2.41E-05 6.55E-05 0 0 0 None 0 0 4.41E-05 1.03605E-03 0
V/M 9283 Ig-78 79 rs727504515 0.2402 -0.304 0.999 D 0.568 0.334 0.419713421852 gnomAD-4.0.0 8.32842E-05 None None None None I None 5.34559E-05 4.18018E-04 None 0 2.23155E-04 None 0 0 1.69993E-05 7.96901E-04 4.8185E-05
I/M 9379 Ig-79 79 rs1060500516 0.1024 -0.342 0.81 None 0.437 0.248 None gnomAD-2.1.1 2.15E-05 None None None None I None 0 0 None 0 0 None 0 None 0 4.71E-05 0
I/M 9379 Ig-79 79 rs1060500516 0.1024 -0.342 0.81 None 0.437 0.248 None gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 0 None 0 0 5.88E-05 0 0
I/M 9379 Ig-79 79 rs1060500516 0.1024 -0.342 0.81 None 0.437 0.248 None gnomAD-4.0.0 1.98447E-05 None None None None I None 0 0 None 0 0 None 0 0 2.71385E-05 0 0
I/T 9379 Ig-79 79 None 0.1158 None 0.549 None 0.462 0.243 0.604632981478 gnomAD-4.0.0 1.59446E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.0281E-05
I/V 9379 Ig-79 79 rs1220876999 0.0687 None 0.002 None 0.238 0.082 0.208816687407 gnomAD-4.0.0 1.59433E-06 None None None None I None 0 0 None 0 2.77316E-05 None 0 0 0 0 0
V/E 9475 Ig-80 79 None 0.3541 None 0.949 None 0.586 0.495 0.822125700771 gnomAD-4.0.0 1.5934E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85881E-06 0 0
V/G 9475 Ig-80 79 rs1363580617 0.2585 -0.31 0.901 None 0.566 0.468 0.864874497995 gnomAD-2.1.1 1.07E-05 None None None None I None 1.24028E-04 0 None 0 0 None 0 None 0 0 0
V/G 9475 Ig-80 79 rs1363580617 0.2585 -0.31 0.901 None 0.566 0.468 0.864874497995 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/G 9475 Ig-80 79 rs1363580617 0.2585 -0.31 0.901 None 0.566 0.468 0.864874497995 gnomAD-4.0.0 3.84761E-06 None None None None I None 5.07614E-05 0 None 0 0 None 0 0 0 0 0
V/L 9475 Ig-80 79 rs754971247 0.3706 -0.016 0.156 None 0.337 0.166 0.224531998449 gnomAD-2.1.1 8.03E-06 None None None None I None 0 5.8E-05 None 0 0 None 0 None 0 0 0
V/L 9475 Ig-80 79 rs754971247 0.3706 -0.016 0.156 None 0.337 0.166 0.224531998449 gnomAD-4.0.0 3.18667E-06 None None None None I None 0 4.57268E-05 None 0 0 None 0 0 0 0 0
A/S 9572 Ig-81 80 rs2076363568 0.1856 None 0.919 None 0.579 0.373 0.291694819147 gnomAD-4.0.0 6.84279E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99582E-07 0 0
A/V 9572 Ig-81 80 None 0.2825 None 0.919 None 0.641 0.364 0.529561333529 gnomAD-4.0.0 1.59165E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8594E-06 0 0
H/R 9777 Ig-83 80 rs776520121 0.2243 0.188 1.0 None 0.667 0.45 0.326616659874 gnomAD-2.1.1 4.01E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.85E-06 0
H/R 9777 Ig-83 80 rs776520121 0.2243 0.188 1.0 None 0.667 0.45 0.326616659874 gnomAD-4.0.0 6.1577E-06 None None None None I None 2.98757E-05 0 None 0 0 None 0 0 6.2962E-06 0 1.65634E-05
R/G 10156 Ig-86 79 rs2075131070 0.879 None 1.0 None 0.767 0.31 0.566121633045 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.54E-05 0 0 0 None 0 0 0 0 0
R/G 10156 Ig-86 79 rs2075131070 0.879 None 1.0 None 0.767 0.31 0.566121633045 gnomAD-4.0.0 6.57013E-06 None None None None N None 0 6.54279E-05 None 0 0 None 0 0 0 0 0
R/S 10156 Ig-86 79 None 0.9625 None 1.0 None 0.778 0.229 0.380730819819 gnomAD-4.0.0 1.59085E-06 None None None None N None 0 2.28624E-05 None 0 0 None 0 0 0 0 0
R/T 10156 Ig-86 79 rs794729403 0.9315 None 1.0 None 0.773 0.293 0.622442570095 gnomAD-4.0.0 3.1817E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71491E-06 0 0
N/K 13764 Ig-87 81 rs1417225547 0.7368 0.475 0.238 N 0.227 0.143 0.173771789658 gnomAD-4.0.0 3.19518E-06 None None None None I None 0 4.5958E-05 None 0 0 None 0 0 0 0 0
N/S 13858 Ig-88 79 rs529917511 0.0894 -0.257 0.136 N 0.181 0.136 0.0846915920261 gnomAD-2.1.1 4.05E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
N/S 13858 Ig-88 79 rs529917511 0.0894 -0.257 0.136 N 0.181 0.136 0.0846915920261 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
N/S 13858 Ig-88 79 rs529917511 0.0894 -0.257 0.136 N 0.181 0.136 0.0846915920261 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
N/S 13858 Ig-88 79 rs529917511 0.0894 -0.257 0.136 N 0.181 0.136 0.0846915920261 gnomAD-4.0.0 6.56978E-06 None None None None N None 2.40558E-05 0 None 0 0 None 0 0 0 0 0
R/I 13953 Ig-89 78 rs1268324463 0.7671 0.573 0.126 N 0.412 0.22 0.353336612579 gnomAD-2.1.1 4.21E-06 None None None None N None 0 0 None 0 0 None 3.39E-05 None 0 0 0
R/I 13953 Ig-89 78 rs1268324463 0.7671 0.573 0.126 N 0.412 0.22 0.353336612579 gnomAD-4.0.0 3.21587E-06 None None None None N None 0 0 None 0 2.80081E-05 None 0 0 0 1.45075E-05 0
K/N 14130 Ig-91 77 None 0.3926 None 0.92 N 0.519 0.153 0.139678290688 gnomAD-4.0.0 2.40078E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31258E-06 0 3.66327E-05
S/N 14219 Ig-92 78 rs748928207 0.0858 0.031 None N 0.241 0.034 0.0611884634855 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
S/N 14219 Ig-92 78 rs748928207 0.0858 0.031 None N 0.241 0.034 0.0611884634855 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/N 14219 Ig-92 78 rs748928207 0.0858 0.031 None N 0.241 0.034 0.0611884634855 gnomAD-4.0.0 3.09942E-06 None None None None N None 0 0 None 0 0 None 0 0 4.23873E-06 0 0
K/T 14307 Ig-93 77 None 0.0522 None None N 0.245 0.173 0.166414681773 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/T 14396 Ig-94 78 None 0.3107 None 0.999 N 0.821 0.459 0.246215685461 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
H/Q 14485 Ig-95 78 rs769249986 0.1509 0.707 0.117 N 0.603 0.14 0.101711395817 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 6.55E-05 None 0 0 0
H/Q 14485 Ig-95 78 rs769249986 0.1509 0.707 0.117 N 0.603 0.14 0.101711395817 gnomAD-4.0.0 2.05328E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.48044E-05 0
H/R 14485 Ig-95 78 rs2059936761 0.0584 None None N 0.286 0.174 0.0806252709748 gnomAD-4.0.0 1.59238E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02737E-05
S/N 14574 Ig-96 78 None 0.1624 None 0.505 N 0.645 0.147 0.238096912614 gnomAD-4.0.0 1.60748E-06 None None None None N None 0 0 None 0 0 None 0 0 2.88386E-06 0 0
K/E 14663 Ig-97 78 rs1271800091 0.0965 None 0.201 N 0.61 0.037 0.15556083564 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/E 14663 Ig-97 78 rs1271800091 0.0965 None 0.201 N 0.61 0.037 0.15556083564 gnomAD-4.0.0 6.57358E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47067E-05 0 0
K/N 14663 Ig-97 78 rs781378924 0.2483 0.033 0.638 N 0.704 0.202 0.143124449307 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.68331E-04 None 0 None 0 0 0
K/N 14663 Ig-97 78 rs781378924 0.2483 0.033 0.638 N 0.704 0.202 0.143124449307 gnomAD-4.0.0 1.59255E-05 None None None None N None 0 0 None 0 2.78272E-04 None 0 0 0 0 0
K/Q 14663 Ig-97 78 rs1271800091 0.0835 None 0.002 N 0.3 0.057 0.126345400529 gnomAD-4.0.0 1.30044E-05 None None None None N None 0 0 None 0 0 None 0 0 1.61931E-05 0 1.65744E-05
K/E 14841 Ig-99 77 rs2058863893 0.1969 None 0.454 N 0.503 0.129 0.167679373172 gnomAD-4.0.0 3.43384E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80294E-06 3.51009E-05 0
R/I 15019 Ig-101 78 rs1553719573 0.3101 None 0.996 N 0.579 0.36 0.294206760003 gnomAD-4.0.0 1.36979E-06 None None None None N None 0 0 None 0 0 None 0 3.47826E-04 0 0 0
R/P 15108 Ig-102 78 rs781435431 0.758 -0.177 0.232 D 0.547 0.253 0.343101102393 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
R/P 15108 Ig-102 78 rs781435431 0.758 -0.177 0.232 D 0.547 0.253 0.343101102393 gnomAD-4.0.0 2.46512E-05 None None None None N None 0 0 None 0 0 None 0 0 3.23983E-05 0 0
R/Q 15108 Ig-102 78 rs781435431 0.0764 -0.027 None N 0.181 0.061 0.115124310173 gnomAD-2.1.1 2.02E-05 None None None None N None 0 2.91E-05 None 0 0 None 6.54E-05 None 0 8.92E-06 1.66778E-04
R/Q 15108 Ig-102 78 rs781435431 0.0764 -0.027 None N 0.181 0.061 0.115124310173 gnomAD-4.0.0 2.53359E-05 None None None None N None 0 4.48451E-05 None 0 0 None 0 1.73853E-04 2.33988E-05 2.32013E-05 9.95454E-05
R/G 15197 Ig-103 78 rs748906368 0.5048 -1.076 0.896 D 0.575 0.279 0.386558576397 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
R/G 15197 Ig-103 78 rs748906368 0.5048 -1.076 0.896 D 0.575 0.279 0.386558576397 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/G 15197 Ig-103 78 rs748906368 0.5048 -1.076 0.896 D 0.575 0.279 0.386558576397 gnomAD-4.0.0 9.92305E-06 None None None None N None 0 6.68919E-05 None 0 0 None 3.1252E-05 0 8.47998E-06 0 0
R/S 15197 Ig-103 78 rs777451653 0.6425 -0.834 0.251 N 0.299 0.096 0.148003135375 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/S 15197 Ig-103 78 rs777451653 0.6425 -0.834 0.251 N 0.299 0.096 0.148003135375 gnomAD-4.0.0 1.59398E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4348E-05 0
R/S 15285 Ig-104 78 rs794729439 0.8858 None 1.0 N 0.635 0.34 0.256283259241 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.8226E-04 0
E/D 15557 Ig-107 78 None 0.2762 None 0.001 N 0.223 0.097 0.225902525712 gnomAD-4.0.0 1.59527E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.03306E-05
E/K 15557 Ig-107 78 None 0.6194 None 0.549 N 0.581 0.321 0.361958692863 gnomAD-4.0.0 6.84954E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00221E-07 0 0
H/Q 15643 Ig-108 76 rs770655963 0.4139 0.282 0.995 N 0.535 0.253 0.394384168047 gnomAD-2.1.1 4.04E-06 None None None None I None 0 2.91E-05 None 0 0 None 0 None 0 0 0
H/Q 15643 Ig-108 76 rs770655963 0.4139 0.282 0.995 N 0.535 0.253 0.394384168047 gnomAD-4.0.0 2.73946E-06 None None None None I None 0 8.96982E-05 None 0 0 None 0 0 0 0 0
H/R 15643 Ig-108 76 rs368502650 0.346 0.045 0.984 N 0.52 0.508 None gnomAD-2.1.1 2.184E-04 None None None None I None 1.65549E-04 3.97682E-04 None 1.25896E-03 0 None 0 None 0 2.19315E-04 2.81532E-04
H/R 15643 Ig-108 76 rs368502650 0.346 0.045 0.984 N 0.52 0.508 None gnomAD-3.1.2 2.36904E-04 None None None None I None 7.24E-05 4.59318E-04 0 1.7311E-03 0 None 0 0 2.94516E-04 0 0
H/R 15643 Ig-108 76 rs368502650 0.346 0.045 0.984 N 0.52 0.508 None 1000 genomes 1.99681E-04 None None None None I None 0 1.4E-03 None None 0 0 None None None 0 None
H/R 15643 Ig-108 76 rs368502650 0.346 0.045 0.984 N 0.52 0.508 None gnomAD-4.0.0 2.72903E-04 None None None None I None 1.06806E-04 3.67438E-04 None 1.28613E-03 0 None 0 0 2.87527E-04 0 5.2888E-04
V/M 16041 Ig-109 74 rs2057419029 0.2941 None 0.781 D 0.61 0.328 0.578523416491 gnomAD-4.0.0 1.36929E-06 None None None None I None 2.99455E-05 0 None 0 0 None 0 0 8.99879E-07 0 0
C/S 16337 Ig-110 76 None 0.516 None 0.001 N 0.347 0.206 0.627239104411 gnomAD-4.0.0 8.9083E-06 None None None None I None 0 0 None 0 0 None 0 0 9.9052E-06 0 3.31917E-05
C/W 16337 Ig-110 76 rs575621631 0.8195 -0.529 0.978 N 0.566 0.376 0.420939154896 gnomAD-2.1.1 4.05E-05 None None None None I None 0 0 None 0 0 None 2.96971E-04 None 0 8.93E-06 0
C/W 16337 Ig-110 76 rs575621631 0.8195 -0.529 0.978 N 0.566 0.376 0.420939154896 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 0 4.14766E-04 0
C/W 16337 Ig-110 76 rs575621631 0.8195 -0.529 0.978 N 0.566 0.376 0.420939154896 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
C/W 16337 Ig-110 76 rs575621631 0.8195 -0.529 0.978 N 0.566 0.376 0.420939154896 gnomAD-4.0.0 2.6688E-05 None None None None I None 0 0 None 0 0 None 0 0 1.69728E-06 4.18677E-04 4.81062E-05
C/Y 16337 Ig-110 76 rs1335648118 0.6847 -0.526 0.921 N 0.563 0.255 0.754999209091 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
C/Y 16337 Ig-110 76 rs1335648118 0.6847 -0.526 0.921 N 0.563 0.255 0.754999209091 gnomAD-4.0.0 1.59713E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86873E-06 0 0
L/V 17033 Ig-111 79 None 0.1242 None 0.174 N 0.454 0.057 0.243972157842 gnomAD-4.0.0 1.59379E-06 None None None None I None 0 0 None 0 2.77917E-05 None 0 0 0 0 0
H/D 17355 Ig-112 105 rs2055715611 0.7141 None 1.0 N 0.633 0.515 0.430351802785 gnomAD-4.0.0 7.24267E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.42625E-05 0
H/N 17355 Ig-112 105 None 0.3204 None 0.999 N 0.639 0.48 0.406394481233 gnomAD-4.0.0 1.44854E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.8525E-05 0
C/Y 17750 Ig-113 74 rs1666217095 0.384 None 0.921 N 0.579 0.266 0.548822617668 gnomAD-4.0.0 4.79106E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29807E-06 0 0
L/R 18051 Ig-114 84 rs771364277 0.5374 0.28 0.994 N 0.674 0.567 0.810086806081 gnomAD-2.1.1 4.1E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.05E-06 0
L/R 18051 Ig-114 84 rs771364277 0.5374 0.28 0.994 N 0.674 0.567 0.810086806081 gnomAD-4.0.0 1.37559E-06 None None None None I None 0 0 None 0 0 None 0 0 1.8065E-06 0 0
A/E 18465 Ig-115 84 rs1375595248 0.6279 -0.402 0.978 N 0.57 0.594 0.493156425868 gnomAD-2.1.1 4.1E-06 None None None None I None 0 0 None 0 5.7E-05 None 0 None 0 0 0
A/E 18465 Ig-115 84 rs1375595248 0.6279 -0.402 0.978 N 0.57 0.594 0.493156425868 gnomAD-4.0.0 4.81413E-06 None None None None I None 0 0 None 0 8.3505E-05 None 0 0 0 0 0
A/S 18465 Ig-115 84 rs899078606 0.1234 -0.19 0.418 N 0.389 0.095 None gnomAD-2.1.1 2.05E-05 None None None None I None 0 0 None 0 0 None 0 None 0 4.5E-05 0
A/S 18465 Ig-115 84 rs899078606 0.1234 -0.19 0.418 N 0.389 0.095 None gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 0 None 0 0 5.89E-05 0 0
A/S 18465 Ig-115 84 rs899078606 0.1234 -0.19 0.418 N 0.389 0.095 None gnomAD-4.0.0 2.98436E-05 None None None None I None 0 0 None 0 0 None 0 0 3.98897E-05 0 1.60777E-05
A/T 18465 Ig-115 84 rs899078606 0.1516 -0.261 0.956 N 0.541 0.376 0.342631996419 gnomAD-2.1.1 8.2E-06 None None None None I None 0 5.94E-05 None 0 0 None 0 None 0 0 0
A/T 18465 Ig-115 84 rs899078606 0.1516 -0.261 0.956 N 0.541 0.376 0.342631996419 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
A/T 18465 Ig-115 84 rs899078606 0.1516 -0.261 0.956 N 0.541 0.376 0.342631996419 gnomAD-4.0.0 1.86523E-06 None None None None I None 0 5.07838E-05 None 0 0 None 0 0 0 0 0
L/R 18770 Ig-116 83 rs1470434078 0.3135 None 0.997 D 0.656 0.604 0.810797851273 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/R 18770 Ig-116 83 rs1470434078 0.3135 None 0.997 D 0.656 0.604 0.810797851273 gnomAD-4.0.0 6.53745E-06 None None None None I None 0 0 None 0 0 None 0 0 1.22197E-05 0 0
A/D 19169 Ig-117 75 rs183460369 0.5268 -0.281 0.055 N 0.563 0.235 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
A/S 19169 Ig-117 75 None 0.1021 None 0.012 N 0.371 0.213 0.251639045875 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/V 19169 Ig-117 75 rs183460369 0.1628 -0.114 0.106 N 0.354 0.164 0.188950314367 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
A/V 19169 Ig-117 75 rs183460369 0.1628 -0.114 0.106 N 0.354 0.164 0.188950314367 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/V 19169 Ig-117 75 rs183460369 0.1628 -0.114 0.106 N 0.354 0.164 0.188950314367 gnomAD-4.0.0 6.57973E-06 None None None None I None 2.41499E-05 0 None 0 0 None 0 0 0 0 0
T/I 19465 Ig-118 75 rs571477228 0.3068 -0.093 0.051 N 0.441 0.221 0.335414705075 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/I 19465 Ig-118 75 rs571477228 0.3068 -0.093 0.051 N 0.441 0.221 0.335414705075 gnomAD-4.0.0 1.59172E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85912E-06 0 0
T/R 19465 Ig-118 75 rs571477228 0.4804 0.233 0.669 N 0.487 0.329 0.422160833541 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.59E-05 None 0 None 0 0 0
T/R 19465 Ig-118 75 rs571477228 0.4804 0.233 0.669 N 0.487 0.329 0.422160833541 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 3.8835E-04 None 0 0 0 0 0
T/R 19465 Ig-118 75 rs571477228 0.4804 0.233 0.669 N 0.487 0.329 0.422160833541 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
T/R 19465 Ig-118 75 rs571477228 0.4804 0.233 0.669 N 0.487 0.329 0.422160833541 gnomAD-4.0.0 3.8439E-06 None None None None I None 0 0 None 0 7.29076E-05 None 0 0 0 0 0
A/D 19863 Ig-119 74 rs1416865059 0.8449 -0.243 1.0 D 0.801 0.568 0.619908932184 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
A/D 19863 Ig-119 74 rs1416865059 0.8449 -0.243 1.0 D 0.801 0.568 0.619908932184 gnomAD-4.0.0 1.59233E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43488E-05 0
A/T 20157 Ig-120 78 rs2050133454 0.1504 None 0.977 D 0.678 0.47 0.491523185611 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 9.41E-05 0 0 0 0
A/T 20157 Ig-120 78 rs2050133454 0.1504 None 0.977 D 0.678 0.47 0.491523185611 gnomAD-4.0.0 6.57601E-06 None None None None I None 0 0 None 0 0 None 9.41265E-05 0 0 0 0
S/N 20555 Ig-121 77 rs1559577387 0.3394 None 0.492 N 0.429 0.235 0.259761712551 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
A/V 20850 Ig-122 82 rs2049701405 0.2128 None 0.085 N 0.478 0.193 0.29527378943 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
A/V 20850 Ig-122 82 rs2049701405 0.2128 None 0.085 N 0.478 0.193 0.29527378943 gnomAD-4.0.0 6.57583E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.06954E-04 0
A/P 21252 Ig-123 76 rs1414305945 0.8804 -0.189 0.999 D 0.701 0.514 0.464442853059 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
A/P 21252 Ig-123 76 rs1414305945 0.8804 -0.189 0.999 D 0.701 0.514 0.464442853059 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/P 21252 Ig-123 76 rs1414305945 0.8804 -0.189 0.999 D 0.701 0.514 0.464442853059 gnomAD-4.0.0 6.58085E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47098E-05 0 0
S/G 21942 Ig-125 77 None 0.1598 None 0.454 N 0.35 0.154 0.279776271856 gnomAD-4.0.0 1.42604E-06 None None None None I None 0 0 None 0 0 None 0 0 9.26063E-07 0 1.73322E-05
S/N 21942 Ig-125 77 rs1274120348 0.3582 0.127 0.022 N 0.205 0.114 0.242825505644 gnomAD-2.1.1 4.44E-06 None None None None I None 0 0 None 1.15527E-04 0 None 0 None 0 0 0
S/N 21942 Ig-125 77 rs1274120348 0.3582 0.127 0.022 N 0.205 0.114 0.242825505644 gnomAD-3.1.2 1.32E-05 None None None None I None 2.41E-05 6.55E-05 0 0 0 None 0 0 0 0 0
S/N 21942 Ig-125 77 rs1274120348 0.3582 0.127 0.022 N 0.205 0.114 0.242825505644 gnomAD-4.0.0 2.57514E-06 None None None None I None 2.74175E-05 1.85694E-05 None 3.61063E-05 0 None 0 0 0 0 0
C/R 22340 Ig-126 76 None 0.6716 None 0.055 N 0.537 0.3 0.514755673002 gnomAD-4.0.0 1.20036E-06 None None None None I None 6.33553E-05 0 None 0 0 None 0 0 0 0 0
F/L 23026 Ig-128 77 None 0.9417 None 0.805 N 0.569 0.39 0.264081493735 gnomAD-4.0.0 1.36896E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79931E-06 0 0
F/S 23026 Ig-128 77 rs375365023 0.5726 -0.35 0.805 N 0.543 0.431 None gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 5.63E-05 None 0 None 0 1.78E-05 0
F/S 23026 Ig-128 77 rs375365023 0.5726 -0.35 0.805 N 0.543 0.431 None gnomAD-3.1.2 1.98E-05 None None None None I None 0 0 0 0 0 None 0 0 4.42E-05 0 0
F/S 23026 Ig-128 77 rs375365023 0.5726 -0.35 0.805 N 0.543 0.431 None gnomAD-4.0.0 9.92121E-06 None None None None I None 0 0 None 0 4.47748E-05 None 0 0 1.1022E-05 0 1.60246E-05
V/A 23712 Ig-130 76 rs1275870840 0.1541 -0.115 0.309 N 0.435 0.236 0.475895305069 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.66334E-04
V/A 23712 Ig-130 76 rs1275870840 0.1541 -0.115 0.309 N 0.435 0.236 0.475895305069 gnomAD-4.0.0 3.18443E-06 None None None None I None 0 0 None 0 0 None 0 4.83325E-04 0 0 0
V/I 23712 Ig-130 76 rs879054551 0.0995 None 0.007 N 0.313 0.098 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
V/I 23712 Ig-130 76 rs879054551 0.0995 None 0.007 N 0.313 0.098 None gnomAD-4.0.0 8.05831E-06 None None None None I None 1.3354E-05 0 None 0 0 None 0 0 1.01727E-05 0 0
G/D 24108 Ig-131 80 rs1056756805 0.9006 0.081 1.0 N 0.689 0.56 0.470318359215 gnomAD-2.1.1 4.04E-06 None None None None I None 0 2.92E-05 None 0 0 None 0 None 0 0 0
G/D 24108 Ig-131 80 rs1056756805 0.9006 0.081 1.0 N 0.689 0.56 0.470318359215 gnomAD-4.0.0 2.74118E-06 None None None None I None 0 2.24487E-05 None 0 0 None 0 0 2.70181E-06 0 0
G/R 24108 Ig-131 80 rs1709100410 0.8348 None 1.0 D 0.747 0.524 0.72159696503 gnomAD-4.0.0 1.59746E-06 None None None None I None 0 0 None 0 2.78272E-05 None 0 0 0 0 0
A/P 24794 Ig-133 79 None 0.8834 None 0.999 D 0.629 0.583 0.58620451499 gnomAD-4.0.0 6.84391E-07 None None None None I None 0 2.23724E-05 None 0 0 None 0 0 0 0 0
A/S 24794 Ig-133 79 None 0.1205 None 0.989 N 0.587 0.407 0.417460480802 gnomAD-4.0.0 6.84391E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99669E-07 0 0
A/V 24794 Ig-133 79 None 0.1015 None 0.117 N 0.403 0.22 0.296329037015 gnomAD-4.0.0 4.80129E-06 None None None None I None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
A/E 25190 Ig-134 80 rs1707808467 0.8732 None 0.998 N 0.538 0.528 0.543165868402 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/E 25190 Ig-134 80 rs1707808467 0.8732 None 0.998 N 0.538 0.528 0.543165868402 gnomAD-4.0.0 6.57877E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47115E-05 0 0
S/N 25587 Ig-135 74 None 0.2801 None 0.722 D 0.505 0.286 0.29385284311 gnomAD-4.0.0 1.20033E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
V/A 25876 Ig-136 79 None 0.107 None 0.051 N 0.257 0.167 0.425970041486 gnomAD-4.0.0 4.8013E-06 None None None None I None 0 0 None 0 0 None 0 0 3.93751E-06 6.07533E-05 0
V/I 25876 Ig-136 79 rs1439203957 0.0873 None 0.454 N 0.414 0.146 0.439975540334 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/V 26272 Ig-137 80 None 0.5238 None 0.994 D 0.651 0.365 0.44750879378 gnomAD-4.0.0 2.06366E-06 None None None None I None 0 0 None 0 0 None 0 0 2.70483E-06 0 0
S/N 26669 Ig-138 76 rs727505214 0.3402 0.12 0.993 D 0.375 0.278 0.381916209588 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
S/N 26669 Ig-138 76 rs727505214 0.3402 0.12 0.993 D 0.375 0.278 0.381916209588 gnomAD-4.0.0 8.2111E-06 None None None None I None 0 0 None 0 0 None 0 0 1.07945E-05 0 0
A/S 26958 Ig-139 79 None 0.1329 None 0.959 N 0.421 0.304 0.290222751274 gnomAD-4.0.0 1.59155E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85883E-06 0 0
A/V 26958 Ig-139 79 None 0.1074 None 0.061 N 0.254 0.156 0.282575091529 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/D 27355 Ig-140 78 rs1474733241 0.9327 -0.029 1.0 N 0.661 0.463 0.463243292966 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
G/D 27355 Ig-140 78 rs1474733241 0.9327 -0.029 1.0 N 0.661 0.463 0.463243292966 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
G/D 27355 Ig-140 78 rs1474733241 0.9327 -0.029 1.0 N 0.661 0.463 0.463243292966 gnomAD-4.0.0 3.71827E-06 None None None None I None 0 1.66722E-05 None 0 0 None 0 0 3.39052E-06 1.09789E-05 0
S/C 27752 Ig-141 77 None 0.0755 None 0.992 N 0.57 0.492 0.553591132476 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/G 27752 Ig-141 77 None 0.0964 None 0.698 N 0.471 0.338 0.289474373501 gnomAD-4.0.0 6.00161E-06 None None None None I None 0 0 None 0 0 None 0 0 6.56251E-06 0 0
S/R 27752 Ig-141 77 rs1704199409 0.7434 None 0.97 D 0.534 0.519 0.477762074677 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/R 27752 Ig-141 77 rs1704199409 0.7434 None 0.97 D 0.534 0.519 0.477762074677 gnomAD-4.0.0 6.57324E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47042E-05 0 0
A/V 28041 Ig-142 79 rs900858263 0.126 -0.028 0.061 N 0.251 0.193 None gnomAD-2.1.1 3.19E-05 None None None None I None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
A/V 28041 Ig-142 79 rs900858263 0.126 -0.028 0.061 N 0.251 0.193 None gnomAD-3.1.2 1.31E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
A/V 28041 Ig-142 79 rs900858263 0.126 -0.028 0.061 N 0.251 0.193 None gnomAD-4.0.0 8.05773E-06 None None None None I None 1.33533E-05 0 None 0 0 None 0 0 1.01718E-05 0 0
A/V 28436 Ig-143 79 rs1559291915 0.3809 None 0.999 N 0.72 0.371 0.48095081912 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
A/V 28436 Ig-143 79 rs1559291915 0.3809 None 0.999 N 0.72 0.371 0.48095081912 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/V 28436 Ig-143 79 rs1559291915 0.3809 None 0.999 N 0.72 0.371 0.48095081912 gnomAD-4.0.0 6.57186E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46985E-05 0 0
L/F 28831 Ig-144 77 rs755136760 0.1208 -0.696 0.884 N 0.452 0.188 0.554957464841 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
S/G 29123 Ig-145 79 rs375198596 0.1041 -0.736 0.071 N 0.254 0.142 None gnomAD-2.1.1 4.02E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
S/G 29123 Ig-145 79 rs375198596 0.1041 -0.736 0.071 N 0.254 0.142 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/G 29123 Ig-145 79 rs375198596 0.1041 -0.736 0.071 N 0.254 0.142 None gnomAD-4.0.0 6.56996E-06 None None None None I None 2.41231E-05 0 None 0 0 None 0 0 0 0 0
S/R 29123 Ig-145 79 rs375198596 0.678 0.025 0.977 N 0.446 0.242 0.290962096972 gnomAD-2.1.1 1.00026E-04 None None None None I None 4.13E-05 1.1309E-04 None 0 0 None 3.27E-05 None 0 1.64145E-04 1.40371E-04
S/R 29123 Ig-145 79 rs375198596 0.678 0.025 0.977 N 0.446 0.242 0.290962096972 gnomAD-3.1.2 9.2E-05 None None None None I None 4.82E-05 0 0 0 0 None 0 0 1.76362E-04 0 0
S/R 29123 Ig-145 79 rs375198596 0.678 0.025 0.977 N 0.446 0.242 0.290962096972 gnomAD-4.0.0 1.08454E-04 None None None None I None 2.66902E-05 8.33278E-05 None 0 0 None 0 0 1.33913E-04 7.68488E-05 4.80307E-05
M/I 29519 Ig-146 76 rs1559234546 0.4805 None None N 0.248 0.137 0.40032279838 gnomAD-4.0.0 6.84201E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99433E-07 0 0
M/T 29519 Ig-146 76 rs1019759612 0.2901 None 0.024 N 0.483 0.292 0.556224665151 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
M/T 29519 Ig-146 76 rs1019759612 0.2901 None 0.024 N 0.483 0.292 0.556224665151 gnomAD-4.0.0 3.09832E-06 None None None None I None 1.33426E-05 0 None 0 2.22926E-05 None 0 0 2.54269E-06 0 0
V/A 29918 Ig-147 77 rs768749427 0.1825 -0.122 0.999 N 0.598 0.413 0.489658423131 gnomAD-2.1.1 3.22E-05 None None None None I None 0 2.32045E-04 None 0 0 None 0 None 0 0 0
V/A 29918 Ig-147 77 rs768749427 0.1825 -0.122 0.999 N 0.598 0.413 0.489658423131 gnomAD-4.0.0 1.91213E-05 None None None None I None 0 2.74461E-04 None 0 0 None 0 0 0 0 0
V/A 30210 Ig-148 79 rs767880082 0.213 0.156 0.004 N 0.285 0.07 0.28798054836 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
V/A 30210 Ig-148 79 rs767880082 0.213 0.156 0.004 N 0.285 0.07 0.28798054836 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 30210 Ig-148 79 rs767880082 0.213 0.156 0.004 N 0.285 0.07 0.28798054836 gnomAD-4.0.0 4.33874E-06 None None None None I None 0 0 None 0 0 None 0 0 5.93375E-06 0 0
V/L 30210 Ig-148 79 rs753025017 0.2449 None 0.004 N 0.229 0.044 0.227260227426 gnomAD-4.0.0 2.05296E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69861E-06 0 0
V/M 30210 Ig-148 79 rs753025017 0.22 -0.15 0.201 N 0.357 0.074 0.326345978581 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 0 None 0 3.57E-05 0
V/M 30210 Ig-148 79 rs753025017 0.22 -0.15 0.201 N 0.357 0.074 0.326345978581 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/M 30210 Ig-148 79 rs753025017 0.22 -0.15 0.201 N 0.357 0.074 0.326345978581 gnomAD-4.0.0 2.0453E-05 None None None None I None 0 0 None 0 0 None 0 0 2.79732E-05 0 0
S/C 30605 Ig-149 74 None 0.0925 None 1.0 N 0.701 0.485 0.499921029546 gnomAD-4.0.0 6.00162E-06 None None None None I None 0 0 None 0 0 None 0 0 6.56252E-06 0 0
S/P 30605 Ig-149 74 rs984360776 0.8413 None 1.0 N 0.703 0.584 0.490074841992 gnomAD-4.0.0 6.85404E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.16274E-05 0
S/T 30605 Ig-149 74 rs984360776 0.1235 0.019 0.999 N 0.569 0.317 None gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.68E-05 0
S/T 30605 Ig-149 74 rs984360776 0.1235 0.019 0.999 N 0.569 0.317 None gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
S/T 30605 Ig-149 74 rs984360776 0.1235 0.019 0.999 N 0.569 0.317 None gnomAD-4.0.0 5.89642E-05 None None None None I None 0 0 None 0 0 None 0 0 7.38634E-05 0 1.28279E-04
S/I 31002 Ig-150 76 rs180975448 0.1501 -0.154 0.949 N 0.627 0.298 None gnomAD-2.1.1 6.25348E-04 None None None None I None 1.23987E-04 5.65E-05 None 1.93536E-04 0 None 0 None 5.59463E-04 1.18274E-03 4.20994E-04
S/I 31002 Ig-150 76 rs180975448 0.1501 -0.154 0.949 N 0.627 0.298 None gnomAD-3.1.2 4.79796E-04 None None None None I None 4.83E-05 6.55E-05 0 0 0 None 2.82912E-04 0 9.7016E-04 0 4.78011E-04
S/I 31002 Ig-150 76 rs180975448 0.1501 -0.154 0.949 N 0.627 0.298 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
S/I 31002 Ig-150 76 rs180975448 0.1501 -0.154 0.949 N 0.627 0.298 None gnomAD-4.0.0 8.25343E-04 None None None None I None 6.66382E-05 6.66689E-05 None 1.35126E-04 0 None 4.21835E-04 0 1.0688E-03 0 4.96159E-04
S/R 31002 Ig-150 76 rs758706423 0.7209 0.076 0.901 N 0.565 0.409 0.345405024496 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
S/R 31694 Ig-152 74 rs776679937 0.9497 0.082 1.0 N 0.698 0.461 0.321672782286 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
C/R 32781 Ig-155 74 rs562178341 0.8504 0.571 1.0 N 0.741 0.5 0.507031862817 gnomAD-2.1.1 2.49539E-04 None None None None I None 0 0 None 0 0 None 1.96078E-03 None 0 1.78E-05 0
C/R 32781 Ig-155 74 rs562178341 0.8504 0.571 1.0 N 0.741 0.5 0.507031862817 gnomAD-3.1.2 3.95E-05 None None None None I None 0 0 0 0 0 None 0 0 0 1.24533E-03 0
C/R 32781 Ig-155 74 rs562178341 0.8504 0.571 1.0 N 0.741 0.5 0.507031862817 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
C/R 32781 Ig-155 74 rs562178341 0.8504 0.571 1.0 N 0.741 0.5 0.507031862817 gnomAD-4.0.0 1.20223E-04 None None None None I None 0 0 None 0 0 None 0 0 3.39045E-06 2.03136E-03 8.00359E-05
C/Y 32781 Ig-155 74 rs1252559965 0.5476 None 1.0 N 0.741 0.355 0.54823119731 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
C/Y 32781 Ig-155 74 rs1252559965 0.5476 None 1.0 N 0.741 0.355 0.54823119731 gnomAD-4.0.0 8.96764E-06 None None None None I None 0 0 None 0 0 None 0 0 1.67512E-05 0 0
V/A 33179 Ig-156 79 rs576759867 0.0975 -0.626 0.001 N 0.261 0.228 0.379366414296 gnomAD-2.1.1 6.06E-05 None None None None I None 8.27E-05 1.98166E-04 None 0 0 None 2.28773E-04 None 0 7.8E-06 0
V/A 33179 Ig-156 79 rs576759867 0.0975 -0.626 0.001 N 0.261 0.228 0.379366414296 gnomAD-3.1.2 1.97E-05 None None None None I None 2.41E-05 6.56E-05 0 0 0 None 0 0 1.47E-05 0 0
V/A 33179 Ig-156 79 rs576759867 0.0975 -0.626 0.001 N 0.261 0.228 0.379366414296 gnomAD-4.0.0 2.97466E-05 None None None None I None 8.01303E-05 1.50105E-04 None 0 2.22806E-05 None 0 3.28947E-04 6.78087E-06 1.86637E-04 8.00589E-05
V/D 33179 Ig-156 79 None 0.4815 -0.31 0.976 N 0.599 0.522 0.775623232837 gnomAD-2.1.1 2.81E-05 None None None None I None 0 2.0304E-04 None 0 0 None 0 None 0 0 0
V/D 33179 Ig-156 79 None 0.4815 -0.31 0.976 N 0.599 0.522 0.775623232837 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/D 33179 Ig-156 79 None 0.4815 -0.31 0.976 N 0.599 0.522 0.775623232837 gnomAD-4.0.0 4.95777E-06 None None None None I None 1.33551E-05 1.16748E-04 None 0 0 None 0 0 0 0 0
V/F 33179 Ig-156 79 rs1452847129 0.1407 None 0.989 N 0.491 0.401 0.667001395416 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/F 33179 Ig-156 79 rs1452847129 0.1407 None 0.989 N 0.491 0.401 0.667001395416 gnomAD-4.0.0 6.57177E-06 None None None None I None 2.4122E-05 0 None 0 0 None 0 0 0 0 0
V/G 33179 Ig-156 79 rs576759867 0.2406 None 0.793 N 0.53 0.393 0.69196344514 gnomAD-4.0.0 6.84213E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99459E-07 0 0
V/I 33179 Ig-156 79 rs1452847129 0.0937 -0.307 0.128 N 0.412 0.143 0.448000600372 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.86E-06 0
F/Y 33276 Ig-157 74 rs1159073081 0.2532 -0.683 0.001 N 0.409 0.106 0.310147130316 gnomAD-2.1.1 3.18E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
F/Y 33276 Ig-157 74 rs1159073081 0.2532 -0.683 0.001 N 0.409 0.106 0.310147130316 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
F/Y 33276 Ig-157 74 rs1159073081 0.2532 -0.683 0.001 N 0.409 0.106 0.310147130316 gnomAD-4.0.0 8.11929E-06 None None None None I None 0 0 None 0 0 None 0 0 9.63925E-06 0 0
F/S 33675 Ig-159 80 None 0.9644 None 1.0 N 0.685 0.581 0.742584921238 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Y/C 34215 Ig-160 79 rs2154135557 0.3594 None 0.999 N 0.569 0.569 0.600692567571 gnomAD-4.0.0 3.18211E-06 None None None None N None 0 0 None 0 5.54539E-05 None 0 0 0 0 0
A/V 34442 Ig-162 80 rs745548644 0.428 -0.039 1.0 N 0.659 0.419 0.541376754579 gnomAD-2.1.1 2.81E-05 None None None None I None 0 0 None 0 0 None 2.28743E-04 None 0 0 0
A/V 34442 Ig-162 80 rs745548644 0.428 -0.039 1.0 N 0.659 0.419 0.541376754579 gnomAD-4.0.0 1.09465E-05 None None None None I None 0 0 None 0 0 None 0 0 0 1.8549E-04 0
K/E 35020 Ig-163 79 rs1689123371 0.9038 None 0.996 N 0.596 0.379 0.468834750356 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92901E-04 None 0 0 0 0 0
K/E 35020 Ig-163 79 rs1689123371 0.9038 None 0.996 N 0.596 0.379 0.468834750356 gnomAD-4.0.0 6.57263E-06 None None None None I None 0 0 None 0 1.92901E-04 None 0 0 0 0 0
K/R 35020 Ig-163 79 rs1178732521 0.1788 None 0.64 N 0.447 0.237 0.323342291347 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/R 35020 Ig-163 79 rs1178732521 0.1788 None 0.64 N 0.447 0.237 0.323342291347 gnomAD-4.0.0 6.57125E-06 None None None None I None 2.41313E-05 0 None 0 0 None 0 0 0 0 0
K/T 35020 Ig-163 79 rs1178732521 0.9058 -0.69 0.999 N 0.635 0.552 0.520427616228 gnomAD-2.1.1 4.02E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
K/T 35020 Ig-163 79 rs1178732521 0.9058 -0.69 0.999 N 0.635 0.552 0.520427616228 gnomAD-4.0.0 1.59094E-06 None None None None I None 5.65227E-05 0 None 0 0 None 0 0 0 0 0
G/A 35365 Ig-165 80 None 0.1438 None 0.999 N 0.668 0.263 0.259761712551 gnomAD-4.0.0 6.84143E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99397E-07 0 0
G/D 35365 Ig-165 80 rs778524334 0.1831 -0.509 1.0 N 0.74 0.439 0.362960570912 gnomAD-2.1.1 7.13E-06 None None None None I None 0 2.83E-05 None 0 0 None 0 None 0 7.8E-06 0
G/D 35365 Ig-165 80 rs778524334 0.1831 -0.509 1.0 N 0.74 0.439 0.362960570912 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/D 35365 Ig-165 80 rs778524334 0.1831 -0.509 1.0 N 0.74 0.439 0.362960570912 gnomAD-4.0.0 1.85889E-06 None None None None I None 0 0 None 0 0 None 0 0 1.69508E-06 0 1.60092E-05
G/S 35365 Ig-165 80 None 0.118 None 1.0 N 0.749 0.296 0.311691414656 gnomAD-4.0.0 4.10486E-06 None None None None I None 0 0 None 0 0 None 0 0 5.39638E-06 0 0
A/P 35498 Ig-166 79 rs878879036 0.7764 None 0.986 N 0.564 0.502 None gnomAD-4.0.0 1.37841E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.20858E-05 1.666E-05
A/S 35498 Ig-166 79 None 0.1075 None 0.867 N 0.517 0.191 0.258779203287 gnomAD-4.0.0 6.89206E-07 None None None None I None 0 0 None 0 0 None 0 0 9.01359E-07 0 0
E/K 35683 Ig-167 77 None 0.1423 None 0.027 N 0.367 0.115 0.194818534648 gnomAD-4.0.0 1.5918E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43427E-05 0
R/C 35780 Ig-168 79 rs1687436055 0.1345 None 0.964 N 0.47 0.33 0.604971122344 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 9.43E-05 0 0 0 0
R/C 35780 Ig-168 79 rs1687436055 0.1345 None 0.964 N 0.47 0.33 0.604971122344 gnomAD-4.0.0 1.15289E-05 None None None None I None 0 0 None 0 0 None 4.70706E-05 0 9.57098E-06 0 5.68699E-05
R/H 35780 Ig-168 79 rs770904787 0.0747 -0.581 None N 0.269 0.128 0.0986583533028 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 2.66E-05 0
R/H 35780 Ig-168 79 rs770904787 0.0747 -0.581 None N 0.269 0.128 0.0986583533028 gnomAD-4.0.0 8.89442E-06 None None None None I None 0 0 None 0 5.0388E-05 None 0 0 6.29605E-06 1.15953E-05 4.96919E-05

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.