Structural position:

  • Domain Type: Ig
  • Aligned Position: 171
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand G

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
T/A 92 Ig-1 87 rs767442718 0.1219 -0.6 0.998 N 0.631 0.415 0.416707687347 gnomAD-2.1.1 3.98E-06 None None None -1.719(TCAP) N None 0 0 None 0 0 None 0 None 0 0 1.6292E-04
T/A 92 Ig-1 87 rs767442718 0.1219 -0.6 0.998 N 0.631 0.415 0.416707687347 gnomAD-3.1.2 6.57E-06 None None None -1.719(TCAP) N None 0 0 0 0 0 None 9.42E-05 0 0 0 0
T/A 92 Ig-1 87 rs767442718 0.1219 -0.6 0.998 N 0.631 0.415 0.416707687347 gnomAD-4.0.0 2.56113E-06 None None None -1.719(TCAP) N None 0 0 None 0 0 None 3.13666E-05 0 0 0 0
T/S 92 Ig-1 87 rs767442718 0.1497 -0.244 0.998 N 0.603 0.387 0.358340041657 gnomAD-2.1.1 3.98E-06 None None None -2.022(TCAP) N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/S 92 Ig-1 87 rs767442718 0.1497 -0.244 0.998 N 0.603 0.387 0.358340041657 gnomAD-4.0.0 1.5905E-06 None None None -2.022(TCAP) N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
T/A 188 Ig-2 85 rs1207248463 0.1981 -0.647 0.94 N 0.544 0.257 0.271763555656 gnomAD-2.1.1 3.98E-06 None None None -1.265(TCAP) N None 0 0 None 0 0 None 0 None 0 8.8E-06 0
T/A 188 Ig-2 85 rs1207248463 0.1981 -0.647 0.94 N 0.544 0.257 0.271763555656 gnomAD-4.0.0 1.36813E-06 None None None -1.265(TCAP) N None 0 0 None 0 0 None 0 1.7337E-04 8.993E-07 0 0
T/I 188 Ig-2 85 rs1470901624 0.5128 None 1.0 N 0.814 0.492 0.645408611234 gnomAD-3.1.2 6.57E-06 None None None -1.285(TCAP) N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 188 Ig-2 85 rs1470901624 0.5128 None 1.0 N 0.814 0.492 0.645408611234 gnomAD-4.0.0 2.47829E-06 None None None -1.285(TCAP) N None 0 0 None 0 0 None 0 0 3.38983E-06 0 0
S/P 1027 Ig-3 85 None 0.9827 None 1.0 N 0.862 0.664 0.612712675542 gnomAD-4.0.0 3.18567E-06 None None None None N None 0 0 None 4.76644E-05 0 None 0 0 2.85771E-06 0 0
S/P 1168 Ig-4 87 rs1488930199 0.7035 None 0.984 D 0.711 0.561 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/P 1168 Ig-4 87 rs1488930199 0.7035 None 0.984 D 0.711 0.561 None gnomAD-4.0.0 4.05949E-06 None None None None I None 0 0 None 0 0 None 0 0 4.81958E-06 0 0
S/P 1376 Ig-5 86 rs1060500425 0.9957 -0.345 1.0 D 0.895 0.723 0.442977140156 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.84E-06 0
S/P 1376 Ig-5 86 rs1060500425 0.9957 -0.345 1.0 D 0.895 0.723 0.442977140156 gnomAD-4.0.0 1.59086E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85708E-06 0 0
S/A 1542 Ig-6 86 None 0.0801 None 0.103 D 0.283 0.303 0.340273420219 gnomAD-4.0.0 1.59132E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85745E-06 0 0
R/S 1642 Ig-7 87 rs943254434 0.9914 None 1.0 N 0.783 0.416 0.353974658523 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/S 1642 Ig-7 87 rs943254434 0.9914 None 1.0 N 0.783 0.416 0.353974658523 gnomAD-4.0.0 2.02984E-06 None None None None I None 3.49443E-05 0 None 0 0 None 0 0 0 0 0
S/F 1789 Ig-8 87 rs2092243043 0.7946 None 1.0 D 0.911 0.609 0.754366180968 gnomAD-4.0.0 3.21046E-06 None None None None N None 0 0 None 0 0 None 0 0 5.7135E-06 0 0
S/P 1789 Ig-8 87 rs775865795 0.9834 -0.319 1.0 D 0.879 0.656 0.554681544945 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 5.52E-05 0 0
K/E 1924 Ig-9 84 rs1327562179 0.2971 0.204 0.183 N 0.411 0.318 0.26169431596 gnomAD-2.1.1 7.96E-06 None None None None I None 0 5.78E-05 None 0 0 None 0 None 0 0 0
K/E 1924 Ig-9 84 rs1327562179 0.2971 0.204 0.183 N 0.411 0.318 0.26169431596 gnomAD-4.0.0 3.42034E-06 None None None None I None 0 4.47207E-05 None 0 0 None 0 0 8.993E-07 2.31863E-05 0
K/N 1924 Ig-9 84 None 0.5546 None 0.351 N 0.425 0.127 0.218112801441 gnomAD-4.0.0 1.5905E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85656E-06 0 0
H/L 2163 Ig-10 86 rs765031763 0.5941 0.756 1.0 N 0.777 0.642 0.667488003546 gnomAD-2.1.1 3.98E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.82E-06 0
H/L 2163 Ig-10 86 rs765031763 0.5941 0.756 1.0 N 0.777 0.642 0.667488003546 gnomAD-4.0.0 4.78868E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29509E-06 0 0
T/A 2257 Ig-11 84 None 0.0947 None 0.948 N 0.507 0.144 0.137902524267 gnomAD-4.0.0 1.59137E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85757E-06 0 0
T/I 2257 Ig-11 84 None 0.1879 None 0.998 N 0.78 0.316 0.282575091529 gnomAD-4.0.0 6.84239E-07 None None None None N None 0 0 None 0 2.52245E-05 None 0 0 0 0 0
T/S 2257 Ig-11 84 rs755999681 0.1024 -0.43 0.775 N 0.321 0.154 0.0846915920261 gnomAD-2.1.1 7.09E-05 None None None None N None 0 0 None 0 9.55158E-04 None 0 None 0 0 1.38966E-04
T/S 2257 Ig-11 84 rs755999681 0.1024 -0.43 0.775 N 0.321 0.154 0.0846915920261 gnomAD-3.1.2 3.94E-05 None None None None N None 0 0 0 0 5.7759E-04 None 0 0 1.47E-05 2.06868E-04 4.78011E-04
T/S 2257 Ig-11 84 rs755999681 0.1024 -0.43 0.775 N 0.321 0.154 0.0846915920261 gnomAD-4.0.0 1.73518E-05 None None None None N None 0 0 None 0 3.12235E-04 None 0 0 8.4755E-07 9.88121E-05 6.40287E-05
T/A 2346 Ig-12 80 rs2091933090 0.0716 None 0.005 N 0.318 0.073 0.0986583533028 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/A 2346 Ig-12 80 rs2091933090 0.0716 None 0.005 N 0.318 0.073 0.0986583533028 gnomAD-4.0.0 6.57194E-06 None None None None N None 2.41348E-05 0 None 0 0 None 0 0 0 0 0
T/N 2346 Ig-12 80 None 0.1012 None 0.029 N 0.519 0.037 0.149567049428 gnomAD-4.0.0 1.36817E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79861E-06 0 0
T/S 2346 Ig-12 80 rs1204644512 0.0787 -0.631 None N 0.269 0.071 0.0401082797425 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14837E-04 0 None 0 0 None 0 None 0 0 0
T/S 2346 Ig-12 80 rs1204644512 0.0787 -0.631 None N 0.269 0.071 0.0401082797425 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
T/S 2346 Ig-12 80 rs1204644512 0.0787 -0.631 None N 0.269 0.071 0.0401082797425 gnomAD-4.0.0 1.85884E-06 None None None None N None 2.67037E-05 0 None 0 2.22806E-05 None 0 0 0 0 0
N/D 2525 Ig-14 81 rs935907056 0.0969 -0.178 0.003 N 0.279 0.11 0.156986980423 gnomAD-2.1.1 1.99E-05 None None None None N None 0 0 None 0 2.72539E-04 None 0 None 0 0 0
N/D 2525 Ig-14 81 rs935907056 0.0969 -0.178 0.003 N 0.279 0.11 0.156986980423 gnomAD-4.0.0 4.10472E-06 None None None None N None 0 0 None 0 1.26027E-04 None 0 0 0 0 1.65596E-05
N/K 2525 Ig-14 81 rs879021503 0.1504 None 0.007 N 0.282 0.077 0.104622674875 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/K 2525 Ig-14 81 rs879021503 0.1504 None 0.007 N 0.282 0.077 0.104622674875 gnomAD-4.0.0 6.5703E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
S/F 2612 Ig-15 80 rs770391975 0.2435 -0.881 0.002 D 0.403 0.175 0.32980341726 gnomAD-2.1.1 3.99E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/F 2612 Ig-15 80 rs770391975 0.2435 -0.881 0.002 D 0.403 0.175 0.32980341726 gnomAD-4.0.0 4.10506E-06 None None None None N None 0 2.23714E-05 None 0 0 None 0 0 3.59748E-06 1.15961E-05 0
S/P 2612 Ig-15 80 rs558027818 0.8355 -0.316 0.497 D 0.716 0.23 0.223847106136 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07383E-04 0
S/P 2612 Ig-15 80 rs558027818 0.8355 -0.316 0.497 D 0.716 0.23 0.223847106136 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
S/P 2612 Ig-15 80 rs558027818 0.8355 -0.316 0.497 D 0.716 0.23 0.223847106136 gnomAD-4.0.0 6.56737E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07555E-04 0
S/A 2699 Ig-16 79 rs373857878 0.0753 -0.336 0.4 D 0.292 0.341 None gnomAD-2.1.1 7.96E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.76E-05 0
S/A 2699 Ig-16 79 rs373857878 0.0753 -0.336 0.4 D 0.292 0.341 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
S/A 2699 Ig-16 79 rs373857878 0.0753 -0.336 0.4 D 0.292 0.341 None gnomAD-4.0.0 2.85014E-05 None None None None N None 0 0 None 0 0 None 0 0 3.6441E-05 0 4.80138E-05
T/K 2965 Ig-19 84 rs1221486073 0.0864 None 0.002 D 0.318 0.277 0.397691132334 gnomAD-4.0.0 4.10926E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49855E-06 0 1.66152E-05
T/A 3048 Ig-20 80 rs74773630 0.0997 None 0.022 N 0.214 0.164 0.208000267992 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/A 3048 Ig-20 80 rs74773630 0.0997 None 0.022 N 0.214 0.164 0.208000267992 gnomAD-4.0.0 3.84454E-06 None None None None N None 0 0 None 0 0 None 0 0 7.17648E-06 0 0
T/P 3048 Ig-20 80 rs74773630 0.5929 -0.541 0.966 D 0.611 0.491 None gnomAD-4.0.0 4.68102E-04 None None None None N None 1.13071E-04 2.28697E-05 None 0 0 None 4.07722E-03 4.82625E-04 1.11434E-04 0 1.06048E-03
S/C 3228 Ig-22 82 rs371249764 0.2365 -0.583 0.999 N 0.541 0.22 None gnomAD-2.1.1 1.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.76E-05 1.63239E-04
S/C 3228 Ig-22 82 rs371249764 0.2365 -0.583 0.999 N 0.541 0.22 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 4.41E-05 0 0
S/C 3228 Ig-22 82 rs371249764 0.2365 -0.583 0.999 N 0.541 0.22 None gnomAD-4.0.0 1.54964E-05 None None None None N None 0 1.667E-05 None 0 0 None 0 0 2.03495E-05 0 0
S/F 3228 Ig-22 82 None 0.4796 None 0.988 N 0.597 0.196 0.33085137897 gnomAD-4.0.0 1.36882E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.15955E-05 1.6564E-05
S/A 3323 Ig-23 85 rs2090015166 0.1029 None 0.116 N 0.205 0.249 0.239305524855 gnomAD-4.0.0 1.36816E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79859E-06 0 0
T/I 3428 Ig-24 84 None 0.198 None 0.994 N 0.707 0.41 0.655434838176 gnomAD-4.0.0 4.80131E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25003E-06 0 0
A/V 3551 Ig-25 87 rs2154335907 0.1311 None None None None 0.168 None gnomAD-4.0.0 1.64654E-06 None None None None N None 0 0 None 0 0 None 0 0 2.96746E-06 0 0
S/L 3744 Ig-26 85 rs794729387 0.1374 None None None None 0.134 None gnomAD-4.0.0 6.85115E-07 None None None None I None 2.99079E-05 0 None 0 0 None 0 0 0 0 0
S/R 3904 Ig-27 85 None 0.4621 None 0.062 N 0.561 0.331 None gnomAD-4.0.0 1.59114E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85791E-06 0 0
A/T 4023 Ig-28 86 None 0.0832 None None N 0.218 0.056 None gnomAD-4.0.0 1.59211E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
S/L 4689 Ig-29 84 rs772266620 0.1037 0.169 0.811 D 0.716 0.533 None gnomAD-2.1.1 1.13E-05 None None None None I None 0 0 None 0 1.30412E-04 None 0 None 0 0 0
S/L 4689 Ig-29 84 rs772266620 0.1037 0.169 0.811 D 0.716 0.533 None gnomAD-4.0.0 5.66341E-06 None None None None I None 0 0 None 0 8.56018E-05 None 0 0 0 0 0
T/I 4784 Ig-30 85 rs376517129 0.2788 -0.031 0.984 N 0.717 0.348 None gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
T/I 4784 Ig-30 85 rs376517129 0.2788 -0.031 0.984 N 0.717 0.348 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 4784 Ig-30 85 rs376517129 0.2788 -0.031 0.984 N 0.717 0.348 None gnomAD-4.0.0 1.85942E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54328E-06 0 0
T/P 4784 Ig-30 85 rs1244858847 0.2861 -0.511 0.984 N 0.725 0.375 0.564392371781 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 1.39743E-04 0 0
T/R 4784 Ig-30 85 None 0.1706 None 0.968 N 0.725 0.358 0.736588646186 gnomAD-4.0.0 6.84345E-07 None None None None N None 0 0 None 0 2.52118E-05 None 0 0 0 0 0
S/L 4972 Ig-32 85 rs868769069 0.0755 None 0.193 N 0.611 0.322 0.522023262976 gnomAD-4.0.0 6.94348E-07 None None None None N None 0 0 None 0 0 None 0 0 9.06462E-07 0 0
S/G 5066 Ig-33 86 rs756793304 0.1311 -0.771 0.896 D 0.562 0.403 0.300110245524 gnomAD-2.1.1 1.79E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.91E-05 0
S/G 5066 Ig-33 86 rs756793304 0.1311 -0.771 0.896 D 0.562 0.403 0.300110245524 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
S/G 5066 Ig-33 86 rs756793304 0.1311 -0.771 0.896 D 0.562 0.403 0.300110245524 gnomAD-4.0.0 4.96147E-05 None None None None N None 0 0 None 0 0 None 0 0 6.44727E-05 0 6.40841E-05
M/I 5159 Ig-34 85 None 0.0671 None None N 0.095 0.147 0.0884992946249 gnomAD-4.0.0 3.26482E-06 None None None None N None 0 0 None 0 0 None 0 0 5.87185E-06 0 0
M/L 5159 Ig-34 85 None 0.0642 None None N 0.098 0.193 0.143124449307 gnomAD-4.0.0 6.90343E-07 None None None None N None 0 0 None 0 0 None 0 0 9.05869E-07 0 0
M/V 5159 Ig-34 85 rs1553929310 0.0517 None None N 0.101 0.17 0.0716867268079 gnomAD-4.0.0 1.38069E-06 None None None None N None 0 0 None 0 0 None 0 0 1.81174E-06 0 0
V/F 5252 Ig-35 85 None 0.0928 None 0.001 N 0.212 0.201 0.312608672186 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 6.17284E-04 0 0 0
E/D 5345 Ig-36 85 rs1298041878 0.1373 -0.231 0.425 N 0.335 0.095 0.282575091529 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
S/G 5534 Ig-38 85 None 0.1144 None 0.549 N 0.473 0.277 0.426551566703 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
S/G 5628 Ig-39 86 None 0.0806 None None N 0.165 0.248 0.256283259241 gnomAD-4.0.0 1.59846E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44047E-05 0
S/N 5628 Ig-39 86 None 0.1282 None 0.055 N 0.433 0.211 0.258779203287 gnomAD-4.0.0 3.19927E-06 None None None None N None 0 0 None 0 0 None 0 0 5.75189E-06 0 0
S/R 5628 Ig-39 86 None 0.4401 None None N 0.329 0.278 0.285698343383 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 3.66327E-05
S/G 5721 Ig-40 85 None 0.0842 None 0.081 D 0.441 0.153 0.19670166235 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/F 5814 Ig-41 85 rs1318339227 0.1459 -0.57 None N 0.463 0.211 0.482500522706 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/F 5814 Ig-41 85 rs1318339227 0.1459 -0.57 None N 0.463 0.211 0.482500522706 gnomAD-4.0.0 1.59141E-06 None None None None N None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
S/P 5814 Ig-41 85 None 0.619 None 0.741 N 0.566 0.525 0.419335720491 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/R 6190 Ig-45 86 rs755474413 0.5021 -0.299 0.949 N 0.726 0.467 0.531245695338 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/R 6190 Ig-45 86 rs755474413 0.5021 -0.299 0.949 N 0.726 0.467 0.531245695338 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07383E-04 0
S/R 6190 Ig-45 86 rs755474413 0.5021 -0.299 0.949 N 0.726 0.467 0.531245695338 gnomAD-4.0.0 3.09869E-06 None None None None N None 0 0 None 0 0 None 0 0 8.47672E-07 4.39203E-05 0
S/G 6283 Ig-46 85 rs779861459 0.0831 -0.852 0.012 N 0.427 0.29 0.281780670237 gnomAD-2.1.1 2.16E-05 None None None None N None 2.48262E-04 0 None 0 0 None 0 None 0 0 0
S/G 6283 Ig-46 85 rs779861459 0.0831 -0.852 0.012 N 0.427 0.29 0.281780670237 gnomAD-3.1.2 4.6E-05 None None None None N None 1.44774E-04 0 0 0 0 None 0 0 1.47E-05 0 0
S/G 6283 Ig-46 85 rs779861459 0.0831 -0.852 0.012 N 0.427 0.29 0.281780670237 gnomAD-4.0.0 7.44794E-06 None None None None N None 1.33586E-04 0 None 0 0 None 0 0 1.69763E-06 0 0
S/I 6283 Ig-46 85 None 0.1306 None 0.093 N 0.649 0.265 0.591671430083 gnomAD-4.0.0 6.85547E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00992E-07 0 0
S/N 6283 Ig-46 85 rs1283369258 0.0914 -0.599 None N 0.221 0.153 0.144782658237 gnomAD-4.0.0 2.05664E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70297E-06 0 0
S/R 6283 Ig-46 85 None 0.3053 None 0.029 N 0.541 0.321 0.230578612272 gnomAD-4.0.0 1.37078E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80165E-06 0 0
Y/C 6376 Ig-47 85 rs747117289 0.1838 -0.588 0.56 N 0.54 0.206 0.471132149292 gnomAD-2.1.1 4.1E-06 None None None None I None 0 0 None 0 0 None 3.41E-05 None 0 0 0
Y/C 6376 Ig-47 85 rs747117289 0.1838 -0.588 0.56 N 0.54 0.206 0.471132149292 gnomAD-4.0.0 1.37537E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.35056E-05 0
S/I 6752 Ig-51 86 None 0.4069 None 0.999 N 0.75 0.515 0.787134533841 gnomAD-4.0.0 1.65984E-06 None None None None N None 0 0 None 0 0 None 0 0 2.98877E-06 0 0
M/I 6939 Ig-53 86 rs748115880 0.1701 -0.175 None N 0.117 0.18 0.419090007872 gnomAD-2.1.1 4.62E-06 None None None None N None 0 0 None 0 6.09E-05 None 0 None 0 0 0
M/I 6939 Ig-53 86 rs748115880 0.1701 -0.175 None N 0.117 0.18 0.419090007872 gnomAD-4.0.0 1.6711E-06 None None None None N None 0 0 None 0 2.81389E-05 None 0 0 0 0 0
M/L 6939 Ig-53 86 None 0.1147 None None N 0.101 0.102 0.466571191598 gnomAD-4.0.0 6.96892E-07 None None None None N None 3.01514E-05 0 None 0 0 None 0 0 0 0 0
M/T 6939 Ig-53 86 None 0.086 None None N 0.175 0.158 0.636139071576 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
M/V 6939 Ig-53 86 None 0.0635 None None N 0.167 0.112 0.318540980066 gnomAD-4.0.0 2.78757E-06 None None None None N None 0 0 None 0 0 None 0 0 3.6454E-06 0 0
T/R 7032 Ig-54 85 rs1361147832 0.1415 -0.058 0.976 N 0.601 0.355 0.591083742983 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
T/R 7032 Ig-54 85 rs1361147832 0.1415 -0.058 0.976 N 0.601 0.355 0.591083742983 gnomAD-4.0.0 4.7913E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29781E-06 0 0
R/C 7128 Ig-55 85 rs727505031 0.1443 -0.11 0.998 N 0.588 0.284 0.702784494799 gnomAD-2.1.1 1.62E-05 None None None None I None 0 0 None 0 0 None 9.87E-05 None 0 8.94E-06 0
R/C 7128 Ig-55 85 rs727505031 0.1443 -0.11 0.998 N 0.588 0.284 0.702784494799 gnomAD-4.0.0 4.79626E-06 None None None None I None 0 0 None 0 0 None 0 0 2.70187E-06 3.48578E-05 1.6592E-05
R/G 7128 Ig-55 85 rs727505031 0.0898 None 0.39 N 0.525 0.279 0.553996833274 gnomAD-4.0.0 6.85179E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.16193E-05 0
R/H 7128 Ig-55 85 rs768531006 0.0727 -1.074 0.98 N 0.611 0.245 None gnomAD-2.1.1 2.87E-05 None None None None I None 8.27E-05 5.67E-05 None 0 0 None 6.6E-05 None 0 1.57E-05 0
R/H 7128 Ig-55 85 rs768531006 0.0727 -1.074 0.98 N 0.611 0.245 None gnomAD-3.1.2 1.97E-05 None None None None I None 2.41E-05 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
R/H 7128 Ig-55 85 rs768531006 0.0727 -1.074 0.98 N 0.611 0.245 None gnomAD-4.0.0 1.11711E-05 None None None None I None 2.6718E-05 3.3389E-05 None 0 2.23065E-05 None 0 0 8.48791E-06 2.20216E-05 1.60385E-05
R/L 7128 Ig-55 85 None 0.1298 None 0.756 N 0.573 0.294 0.557325494615 gnomAD-4.0.0 6.8534E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00799E-07 0 0
T/A 7221 Ig-56 85 rs879220825 0.0957 None 0.704 N 0.371 0.33 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/A 7221 Ig-56 85 rs879220825 0.0957 None 0.704 N 0.371 0.33 None gnomAD-4.0.0 6.57142E-06 None None None None N None 2.41173E-05 0 None 0 0 None 0 0 0 0 0
T/I 7221 Ig-56 85 rs1360941673 0.2279 None 0.988 N 0.603 0.385 0.636959685889 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
T/P 7221 Ig-56 85 rs879220825 0.1622 -0.537 0.035 D 0.329 0.327 0.417460480802 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
T/P 7221 Ig-56 85 rs879220825 0.1622 -0.537 0.035 D 0.329 0.327 0.417460480802 gnomAD-4.0.0 1.59337E-06 None None None None N None 0 2.28969E-05 None 0 0 None 0 0 0 0 0
G/R 7314 Ig-57 85 rs2078695205 0.0954 None None N 0.425 0.084 0.355865052028 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/R 7314 Ig-57 85 rs2078695205 0.0954 None None N 0.425 0.084 0.355865052028 gnomAD-4.0.0 2.56307E-06 None None None None I None 1.69193E-05 1.69578E-05 None 0 0 None 0 0 0 0 0
K/N 7407 Ig-58 85 rs548543520 0.1576 0.213 0.001 N 0.231 0.098 0.115124310173 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 3.29E-05 None 0 0 0
K/N 7407 Ig-58 85 rs548543520 0.1576 0.213 0.001 N 0.231 0.098 0.115124310173 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06868E-04 0
K/N 7407 Ig-58 85 rs548543520 0.1576 0.213 0.001 N 0.231 0.098 0.115124310173 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
K/N 7407 Ig-58 85 rs548543520 0.1576 0.213 0.001 N 0.231 0.098 0.115124310173 gnomAD-4.0.0 4.05938E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.87882E-04 0
K/R 7407 Ig-58 85 None 0.0772 None 0.096 N 0.481 0.101 0.181679512989 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
S/R 7503 Ig-59 85 None 0.4124 None 0.001 N 0.269 0.185 0.297375071883 gnomAD-4.0.0 3.45723E-06 None None None None N None 0 0 None 0 0 None 0 0 3.62171E-06 1.21021E-05 0
S/L 7599 Ig-60 85 None 0.0922 None 0.997 N 0.651 0.445 0.72449871023 gnomAD-4.0.0 1.59696E-06 None None None None N None 0 2.29179E-05 None 0 0 None 0 0 0 0 0
S/P 7599 Ig-60 85 None 0.5015 None 1.0 N 0.685 0.531 0.525561869914 gnomAD-4.0.0 1.5965E-06 None None None None N None 0 0 None 0 2.77362E-05 None 0 0 0 0 0
S/G 7693 Ig-61 86 None 0.1728 None 0.738 N 0.579 0.416 0.414021929199 gnomAD-4.0.0 7.20196E-06 None None None None N None 0 0 None 0 0 None 0 0 7.87505E-06 0 0
S/Y 7786 Ig-62 85 rs794729628 0.123 -0.324 0.033 N 0.537 0.149 0.334161072951 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
S/Y 7786 Ig-62 85 rs794729628 0.123 -0.324 0.033 N 0.537 0.149 0.334161072951 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
S/Y 7786 Ig-62 85 rs794729628 0.123 -0.324 0.033 N 0.537 0.149 0.334161072951 gnomAD-4.0.0 7.6957E-06 None None None None N None 0 0 None 0 0 None 0 0 1.43755E-05 0 0
S/T 7880 Ig-63 86 rs1158110251 0.0909 -0.408 0.625 N 0.52 0.184 0.225215365344 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 5.62E-05 None 0 None 0 0 0
S/T 7880 Ig-63 86 rs1158110251 0.0909 -0.408 0.625 N 0.52 0.184 0.225215365344 gnomAD-4.0.0 3.19568E-06 None None None None N None 0 0 None 0 5.56204E-05 None 0 0 0 0 0
T/A 7973 Ig-64 85 None 0.0782 None 0.027 D 0.441 0.121 0.190952846119 gnomAD-4.0.0 1.59876E-06 None None None None N None 0 0 None 0 2.77546E-05 None 0 0 0 0 0
T/I 7973 Ig-64 85 rs768738299 0.1479 0.054 0.317 N 0.657 0.336 0.459906663326 gnomAD-2.1.1 4.04E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
T/I 7973 Ig-64 85 rs768738299 0.1479 0.054 0.317 N 0.657 0.336 0.459906663326 gnomAD-4.0.0 1.59921E-06 None None None None N None 5.66829E-05 0 None 0 0 None 0 0 0 0 0
S/L 8069 Ig-65 85 rs751657368 0.1164 0.15 0.896 N 0.621 0.383 0.59202398213 gnomAD-2.1.1 8.09E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.98E-06 1.66556E-04
S/L 8069 Ig-65 85 rs751657368 0.1164 0.15 0.896 N 0.621 0.383 0.59202398213 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/L 8069 Ig-65 85 rs751657368 0.1164 0.15 0.896 N 0.621 0.383 0.59202398213 gnomAD-4.0.0 3.84483E-06 None None None None N None 0 0 None 0 0 None 0 0 2.39425E-06 0 5.69022E-05
E/A 8255 Ig-67 85 rs794727943 0.1569 -0.376 0.012 N 0.437 0.145 0.333154297509 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
S/G 8444 Ig-69 85 rs547641733 0.1364 -0.835 0.966 N 0.47 0.331 0.360565625551 gnomAD-2.1.1 8.17E-06 None None None None I None 6.49E-05 0 None 0 0 None 0 None 0 9.02E-06 0
S/G 8444 Ig-69 85 rs547641733 0.1364 -0.835 0.966 N 0.47 0.331 0.360565625551 gnomAD-3.1.2 1.31E-05 None None None None I None 4.82E-05 0 0 0 0 None 0 0 0 0 0
S/G 8444 Ig-69 85 rs547641733 0.1364 -0.835 0.966 N 0.47 0.331 0.360565625551 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
S/G 8444 Ig-69 85 rs547641733 0.1364 -0.835 0.966 N 0.47 0.331 0.360565625551 gnomAD-4.0.0 1.2913E-05 None None None None I None 5.08492E-05 0 None 0 0 None 0 0 4.83017E-06 0 1.43373E-04
S/A 8540 Ig-70 85 rs77120780 0.0868 -0.176 None N 0.145 0.153 0.162503812791 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/A 8540 Ig-70 85 rs77120780 0.0868 -0.176 None N 0.145 0.153 0.162503812791 gnomAD-4.0.0 1.59295E-06 None None None None I None 0 2.28718E-05 None 0 0 None 0 0 0 0 0
S/F 8540 Ig-70 85 rs201523784 0.1459 -0.895 None N 0.354 0.342 None gnomAD-2.1.1 5.36569E-04 None None None None I None 8.27E-05 4.81559E-04 None 3.9721E-03 0 None 2.61832E-04 None 4.02E-05 6.10902E-04 4.22654E-04
S/F 8540 Ig-70 85 rs201523784 0.1459 -0.895 None N 0.354 0.342 None gnomAD-3.1.2 4.27148E-04 None None None None I None 1.92957E-04 1.96464E-04 0 2.88184E-03 0 None 9.41E-05 0 5.73378E-04 8.27815E-04 0
S/F 8540 Ig-70 85 rs201523784 0.1459 -0.895 None N 0.354 0.342 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
S/F 8540 Ig-70 85 rs201523784 0.1459 -0.895 None N 0.354 0.342 None gnomAD-4.0.0 6.03203E-04 None None None None I None 1.33319E-04 4.00027E-04 None 3.92343E-03 0 None 1.09419E-04 0 6.35127E-04 1.97863E-04 7.84753E-04
S/Y 8540 Ig-70 85 None 0.1791 None 0.001 N 0.428 0.273 0.496165130923 gnomAD-4.0.0 6.84575E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.16093E-05 0
S/C 8634 Ig-71 86 rs769050572 0.2948 -0.212 0.827 D 0.771 0.519 0.628150982837 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.67094E-04 None 0 None 0 0 0
S/C 8634 Ig-71 86 rs769050572 0.2948 -0.212 0.827 D 0.771 0.519 0.628150982837 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92678E-04 None 0 0 0 0 0
S/C 8634 Ig-71 86 rs769050572 0.2948 -0.212 0.827 D 0.771 0.519 0.628150982837 gnomAD-4.0.0 3.10148E-06 None None None None N None 0 0 None 0 1.11488E-04 None 0 0 0 0 0
V/F 8727 Ig-72 85 rs544958705 0.0759 None 0.11 N 0.565 0.054 0.242825505644 gnomAD-4.0.0 3.42702E-06 None None None None N None 0 0 None 0 0 None 1.87645E-05 0 3.60274E-06 0 0
V/G 8727 Ig-72 85 None 0.1033 None 0.018 N 0.476 0.063 0.159798565429 gnomAD-4.0.0 1.597E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44254E-05 0
V/I 8727 Ig-72 85 rs544958705 0.0619 -0.609 None N 0.143 0.109 0.0716867268079 gnomAD-2.1.1 1.08E-05 None None None None N None 4.14E-05 0 None 0 5.12E-05 None 3.33E-05 None 0 0 0
V/I 8727 Ig-72 85 rs544958705 0.0619 -0.609 None N 0.143 0.109 0.0716867268079 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 1.9305E-04 None 0 0 0 2.07469E-04 0
V/I 8727 Ig-72 85 rs544958705 0.0619 -0.609 None N 0.143 0.109 0.0716867268079 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
V/I 8727 Ig-72 85 rs544958705 0.0619 -0.609 None N 0.143 0.109 0.0716867268079 gnomAD-4.0.0 1.05509E-05 None None None None N None 4.00043E-05 0 None 0 2.22955E-05 None 0 0 7.63829E-06 3.31558E-05 1.60267E-05
T/A 8914 Ig-74 85 rs1387091014 0.0904 -0.612 0.055 N 0.547 0.147 0.222439326576 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/A 8914 Ig-74 85 rs1387091014 0.0904 -0.612 0.055 N 0.547 0.147 0.222439326576 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
T/A 8914 Ig-74 85 rs1387091014 0.0904 -0.612 0.055 N 0.547 0.147 0.222439326576 gnomAD-4.0.0 2.56299E-06 None None None None N None 0 3.39109E-05 None 0 0 None 0 0 0 0 0
S/G 9010 Ig-75 85 None 0.0954 None None D 0.213 0.184 0.168933306366 gnomAD-4.0.0 1.36867E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7992E-06 0 0
S/R 9010 Ig-75 85 rs774115714 0.1565 -0.333 0.295 N 0.624 0.121 0.277317399466 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
S/R 9010 Ig-75 85 rs774115714 0.1565 -0.333 0.295 N 0.624 0.121 0.277317399466 gnomAD-4.0.0 6.36809E-06 None None None None N None 0 0 None 0 0 None 0 0 1.1439E-05 0 0
T/A 9103 Ig-76 85 rs1351836200 0.0984 -0.684 0.704 N 0.495 0.241 0.289847578895 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 1.92678E-04 None 0 0 1.47E-05 0 0
T/A 9103 Ig-76 85 rs1351836200 0.0984 -0.684 0.704 N 0.495 0.241 0.289847578895 gnomAD-4.0.0 1.31401E-05 None None None None N None 0 0 None 0 1.92678E-04 None 0 0 1.46994E-05 0 0
S/L 9196 Ig-77 85 None 0.0922 None 0.183 D 0.481 0.328 0.343101102393 gnomAD-4.0.0 8.40225E-06 None None None None N None 0 0 None 0 0 None 0 0 9.18751E-06 0 0
S/T 9196 Ig-77 85 rs1350223598 0.069 None 0.183 N 0.325 0.136 0.248417906384 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/T 9196 Ig-77 85 rs1350223598 0.069 None 0.183 N 0.325 0.136 0.248417906384 gnomAD-4.0.0 3.0448E-06 None None None None N None 0 0 None 0 0 None 0 0 3.61481E-06 0 0
S/P 9289 Ig-78 85 rs2076724301 0.2865 None 0.004 N 0.279 0.327 0.273938319068 gnomAD-4.0.0 8.09961E-06 None None None None I None 0 0 None 0 1.39098E-04 None 0 0 0 0 0
S/N 9385 Ig-79 85 rs945228543 0.1815 -0.185 None None 0.219 0.12 0.264081493735 gnomAD-2.1.1 4.25E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.26E-06 0
S/N 9385 Ig-79 85 rs945228543 0.1815 -0.185 None None 0.219 0.12 0.264081493735 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
S/N 9385 Ig-79 85 rs945228543 0.1815 -0.185 None None 0.219 0.12 0.264081493735 gnomAD-4.0.0 4.39068E-06 None None None None N None 0 1.75439E-05 None 0 0 None 0 0 5.12615E-06 0 0
S/R 9385 Ig-79 85 rs2076586234 0.6011 None None None 0.283 0.185 0.292423486923 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 9578 Ig-81 86 rs1370314453 0.1937 -0.866 0.679 None 0.4 0.166 0.301789629655 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
T/A 9578 Ig-81 86 rs1370314453 0.1937 -0.866 0.679 None 0.4 0.166 0.301789629655 gnomAD-4.0.0 1.59847E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87781E-06 0 0
T/K 9578 Ig-81 86 None 0.6161 None 0.729 None 0.481 0.282 0.413113201963 gnomAD-4.0.0 6.85554E-07 None None None None N None 0 0 None 0 0 None 0 0 9.014E-07 0 0
T/M 9578 Ig-81 86 rs184923756 0.2155 -0.067 0.998 None 0.623 0.395 None gnomAD-2.1.1 1.53731E-04 None None None None N None 0 2.83E-05 None 0 0 None 3.27E-05 None 0 3.13063E-04 1.40766E-04
T/M 9578 Ig-81 86 rs184923756 0.2155 -0.067 0.998 None 0.623 0.395 None gnomAD-3.1.2 2.62826E-04 None None None None N None 4.82E-05 0 2.41228E-02 0 0 None 0 0 2.3517E-04 0 0
T/M 9578 Ig-81 86 rs184923756 0.2155 -0.067 0.998 None 0.623 0.395 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
T/M 9578 Ig-81 86 rs184923756 0.2155 -0.067 0.998 None 0.623 0.395 None gnomAD-4.0.0 1.85601E-04 None None None None N None 6.66702E-05 1.66756E-05 None 0 0 None 1.56362E-05 0 2.19974E-04 1.09914E-05 1.60395E-04
K/Q 9674 Ig-82 85 None 0.2309 None 0.968 None 0.631 0.248 0.292423486923 gnomAD-4.0.0 6.84432E-06 None None None None N None 0 0 None 0 0 None 0 0 8.09765E-06 0 1.65678E-05
N/I 9783 Ig-83 86 rs1254488322 0.3473 0.222 0.876 None 0.721 0.239 0.66477970535 gnomAD-2.1.1 4.01E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.85E-06 0
N/I 9783 Ig-83 86 rs1254488322 0.3473 0.222 0.876 None 0.721 0.239 0.66477970535 gnomAD-4.0.0 1.36835E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79887E-06 0 0
N/K 9783 Ig-83 86 rs1183091830 0.5605 None 0.801 None 0.529 0.194 0.0884992946249 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/K 9783 Ig-83 86 rs1183091830 0.5605 None 0.801 None 0.529 0.194 0.0884992946249 gnomAD-4.0.0 6.19684E-06 None None None None I None 0 0 None 0 0 None 0 0 7.62817E-06 0 1.60097E-05
S/N 9981 Ig-84 82 None 0.6179 None 0.939 None 0.545 0.282 0.149567049428 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.93751E-06 0 0
S/T 9981 Ig-84 82 None 0.3818 None 0.969 None 0.479 0.263 0.134241683229 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
S/L 10068 Ig-85 80 rs756434866 0.1869 -0.09 0.326 None 0.507 0.296 0.455816718377 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.85E-06 0
S/L 10068 Ig-85 80 rs756434866 0.1869 -0.09 0.326 None 0.507 0.296 0.455816718377 gnomAD-4.0.0 4.77351E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57305E-06 0 0
S/T 10068 Ig-85 80 rs1410740071 0.0744 -0.512 0.005 None 0.225 0.097 0.104622674875 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.85E-06 0
S/T 10068 Ig-85 80 rs1410740071 0.0744 -0.512 0.005 None 0.225 0.097 0.104622674875 gnomAD-4.0.0 5.47342E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19528E-06 0 0
T/M 10162 Ig-86 85 rs200593368 0.4181 -1.242 1.0 None 0.767 0.335 None gnomAD-2.1.1 3.95463E-04 None None None None N None 1.23967E-04 2.83E-05 None 0 0 None 3.27E-05 None 1.19914E-04 7.70656E-04 5.60067E-04
T/M 10162 Ig-86 85 rs200593368 0.4181 -1.242 1.0 None 0.767 0.335 None gnomAD-3.1.2 2.8269E-04 None None None None N None 4.83E-05 1.30924E-04 0 0 0 None 0 0 5.73361E-04 0 0
T/M 10162 Ig-86 85 rs200593368 0.4181 -1.242 1.0 None 0.767 0.335 None 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
T/M 10162 Ig-86 85 rs200593368 0.4181 -1.242 1.0 None 0.767 0.335 None gnomAD-4.0.0 5.68179E-04 None None None None N None 7.99723E-05 8.33056E-05 None 0 0 None 1.87553E-04 0 7.40757E-04 1.09791E-05 3.04097E-04
T/R 10162 Ig-86 85 None 0.7492 None 1.0 None 0.812 0.396 0.375147631797 gnomAD-4.0.0 6.84135E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
T/K 13770 Ig-87 87 rs774214497 0.2615 -0.565 0.993 N 0.74 0.457 0.495506531988 gnomAD-2.1.1 8.12E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
T/K 13770 Ig-87 87 rs774214497 0.2615 -0.565 0.993 N 0.74 0.457 0.495506531988 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
T/K 13770 Ig-87 87 rs774214497 0.2615 -0.565 0.993 N 0.74 0.457 0.495506531988 gnomAD-4.0.0 1.36731E-05 None None None None N None 0 1.67718E-05 None 0 0 None 0 0 1.78409E-05 0 0
T/M 13770 Ig-87 87 rs774214497 0.1426 0.063 0.947 D 0.527 0.401 0.661236301376 gnomAD-2.1.1 1.44E-05 None None None None N None 8.3E-05 0 None 0 0 None 3.32E-05 None 0 7.88E-06 0
T/M 13770 Ig-87 87 rs774214497 0.1426 0.063 0.947 D 0.527 0.401 0.661236301376 gnomAD-3.1.2 3.95E-05 None None None None N None 1.20703E-04 0 0 0 1.93949E-04 None 0 0 0 0 0
T/M 13770 Ig-87 87 rs774214497 0.1426 0.063 0.947 D 0.527 0.401 0.661236301376 gnomAD-4.0.0 2.54817E-05 None None None None N None 1.07164E-04 0 None 0 6.72646E-05 None 0 0 2.29384E-05 3.31301E-05 0
T/I 14048 Ig-90 84 rs1362774927 0.5825 0.145 0.524 N 0.369 0.229 0.227260227426 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
T/I 14048 Ig-90 84 rs1362774927 0.5825 0.145 0.524 N 0.369 0.229 0.227260227426 gnomAD-4.0.0 1.59287E-06 None None None None N None 0 2.28927E-05 None 0 0 None 0 0 0 0 0
K/E 14309 Ig-93 79 rs908530219 0.1122 0.431 0.101 N 0.515 0.108 0.229924730088 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
K/E 14309 Ig-93 79 rs908530219 0.1122 0.431 0.101 N 0.515 0.108 0.229924730088 gnomAD-4.0.0 7.9614E-06 None None None None N None 0 0 None 0 0 None 0 0 1.42989E-05 0 0
K/R 14309 Ig-93 79 None 0.0894 None 0.213 N 0.496 0.095 0.274366138417 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 1.94099E-04 0 None 0 0 0 0 0
E/D 14576 Ig-96 80 rs2059887761 0.2066 None 0.977 N 0.506 0.228 0.286081765059 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/D 14576 Ig-96 80 rs2059887761 0.2066 None 0.977 N 0.506 0.228 0.286081765059 gnomAD-4.0.0 1.31487E-05 None None None None N None 4.82649E-05 0 None 0 0 None 0 0 0 0 0
S/A 14665 Ig-97 80 None 0.0768 None 0.022 N 0.224 0.065 0.141422826196 gnomAD-4.0.0 2.73805E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59853E-06 0 0
D/N 15110 Ig-102 80 rs17354992 0.0952 0.103 0.002 N 0.186 0.21 None gnomAD-2.1.1 7.95716E-03 None None None None N None 1.20043E-03 2.36091E-03 None 1.21289E-02 5.19E-05 None 7.88871E-03 None 3.01489E-02 7.42054E-03 5.92718E-03
D/N 15110 Ig-102 80 rs17354992 0.0952 0.103 0.002 N 0.186 0.21 None gnomAD-3.1.2 6.79528E-03 None None None None N None 1.25622E-03 3.94633E-03 7.69231E-03 1.0951E-02 0 None 2.8819E-02 0 7.81871E-03 6.41822E-03 3.35249E-03
D/N 15110 Ig-102 80 rs17354992 0.0952 0.103 0.002 N 0.186 0.21 None 1000 genomes 2.99521E-03 None None None None N None 0 2.9E-03 None None 0 7E-03 None None None 6.1E-03 None
D/N 15110 Ig-102 80 rs17354992 0.0952 0.103 0.002 N 0.186 0.21 None gnomAD-4.0.0 7.5279E-03 None None None None N None 1.12132E-03 2.7084E-03 None 1.07621E-02 4.48129E-05 None 2.69468E-02 6.61813E-04 7.38483E-03 8.32802E-03 5.9478E-03
A/E 15199 Ig-103 80 None 0.4129 None 0.27 N 0.484 0.147 0.329282125956 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
A/T 15199 Ig-103 80 None 0.1033 None 0.01 N 0.26 0.065 0.20549828249 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
A/T 15292 Ig-104 85 None 0.0716 None 0.022 N 0.162 0.046 0.251116650651 gnomAD-4.0.0 6.8465E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99944E-07 0 0
A/V 15292 Ig-104 85 rs1419332401 0.1133 None 0.801 N 0.488 0.208 0.511907979761 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
A/V 15292 Ig-104 85 rs1419332401 0.1133 None 0.801 N 0.488 0.208 0.511907979761 gnomAD-4.0.0 1.31621E-05 None None None None N None 4.83162E-05 0 None 0 0 None 0 0 0 0 0
V/A 15381 Ig-105 80 rs369269320 0.1815 -0.812 0.001 N 0.229 0.096 0.279776271856 gnomAD-2.1.1 3.60628E-04 None None None None N None 0 0 None 0 0 None 2.83604E-03 None 0 8.96E-06 3.34113E-04
V/A 15381 Ig-105 80 rs369269320 0.1815 -0.812 0.001 N 0.229 0.096 0.279776271856 gnomAD-3.1.2 1.38256E-04 None None None None N None 0 0 0 0 0 None 0 0 0 4.35504E-03 0
V/A 15381 Ig-105 80 rs369269320 0.1815 -0.812 0.001 N 0.229 0.096 0.279776271856 1000 genomes 5.99042E-04 None None None None N None 0 0 None None 0 0 None None None 3.1E-03 None
V/A 15381 Ig-105 80 rs369269320 0.1815 -0.812 0.001 N 0.229 0.096 0.279776271856 gnomAD-4.0.0 1.46468E-04 None None None None N None 0 0 None 0 0 None 0 1.65618E-04 3.39416E-06 2.39266E-03 2.2451E-04
F/L 15649 Ig-108 82 rs563370509 0.7129 -0.725 0.896 N 0.612 0.228 0.651024515444 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14705E-04 0 None 0 0 None 0 None 0 0 0
F/L 15649 Ig-108 82 rs563370509 0.7129 -0.725 0.896 N 0.612 0.228 0.651024515444 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
F/L 15649 Ig-108 82 rs563370509 0.7129 -0.725 0.896 N 0.612 0.228 0.651024515444 gnomAD-4.0.0 4.34229E-06 None None None None N None 9.35029E-05 0 None 0 0 None 0 0 0 0 0
V/M 16343 Ig-110 82 rs2056942530 0.2546 None 0.667 N 0.586 0.165 0.619546946635 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/T 17039 Ig-111 85 None 0.0665 None 0.007 N 0.177 0.105 0.257786959452 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/S 17361 Ig-112 111 None 0.0853 None 0.001 N 0.201 0.116 0.225215365344 gnomAD-4.0.0 1.86637E-06 None None None None I None 0 0 None 0 0 None 0 0 3.23532E-06 0 0
N/H 18057 Ig-114 90 None 0.1184 None 0.989 N 0.54 0.347 0.326881540566 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/S 18057 Ig-114 90 rs779769456 0.0983 -0.387 0.022 N 0.155 0.151 0.167679373172 gnomAD-2.1.1 4.17E-06 None None None None N None 0 0 None 0 5.61E-05 None 0 None 0 0 0
N/S 18057 Ig-114 90 rs779769456 0.0983 -0.387 0.022 N 0.155 0.151 0.167679373172 gnomAD-4.0.0 2.07167E-06 None None None None N None 0 0 None 0 5.05945E-05 None 0 0 9.05797E-07 0 0
N/T 18057 Ig-114 90 None 0.1314 None 0.022 N 0.149 0.132 0.289474373501 gnomAD-4.0.0 6.90558E-07 None None None None N None 0 0 None 0 2.52972E-05 None 0 0 0 0 0
N/D 18471 Ig-115 90 None 0.2205 None 0.722 N 0.563 0.198 0.18274738541 gnomAD-4.0.0 1.62081E-06 None None None None N None 0 0 None 0 0 None 0 0 2.88507E-06 0 0
N/I 18471 Ig-115 90 None 0.1395 None 0.949 N 0.8 0.325 0.590905048371 gnomAD-4.0.0 4.87824E-06 None None None None N None 0 0 None 0 0 None 0 0 8.66852E-06 0 0
N/S 18471 Ig-115 90 rs1310909549 0.0664 0.045 0.034 N 0.366 0.101 0.101711395817 gnomAD-2.1.1 1.7E-05 None None None None N None 0 0 None 0 2.35599E-04 None 0 None 0 0 0
N/S 18471 Ig-115 90 rs1310909549 0.0664 0.045 0.034 N 0.366 0.101 0.101711395817 gnomAD-4.0.0 1.62608E-06 None None None None N None 0 0 None 0 2.78489E-05 None 0 0 0 0 0
E/K 18776 Ig-116 89 rs987030753 0.4101 None 0.92 N 0.479 0.25 0.319114376414 gnomAD-4.0.0 1.65905E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.54226E-05 0
T/I 19175 Ig-117 81 rs1450515648 0.2894 0.233 0.81 N 0.581 0.199 0.341696514166 gnomAD-2.1.1 8.12E-06 None None None None N None 0 2.93E-05 None 0 0 None 0 None 0 8.97E-06 0
T/I 19175 Ig-117 81 rs1450515648 0.2894 0.233 0.81 N 0.581 0.199 0.341696514166 gnomAD-4.0.0 3.19038E-06 None None None None N None 0 2.29758E-05 None 0 0 None 0 0 2.86267E-06 0 0
T/K 19175 Ig-117 81 rs1450515648 0.3512 -0.118 0.379 N 0.498 0.202 0.292062946507 gnomAD-2.1.1 7.2E-06 None None None None N None 4.15E-05 0 None 0 0 None 0 None 0 7.88E-06 0
T/K 19175 Ig-117 81 rs1450515648 0.3512 -0.118 0.379 N 0.498 0.202 0.292062946507 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/K 19175 Ig-117 81 rs1450515648 0.3512 -0.118 0.379 N 0.498 0.202 0.292062946507 gnomAD-4.0.0 6.57549E-06 None None None None N None 2.41289E-05 0 None 0 0 None 0 0 0 0 0
F/I 19471 Ig-118 81 None 0.0797 None None N 0.104 0.092 0.168933306366 gnomAD-4.0.0 6.8434E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99559E-07 0 0
F/L 19471 Ig-118 81 rs867902753 0.5755 None None N 0.118 0.092 0.556540827966 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
F/L 19471 Ig-118 81 rs867902753 0.5755 None None N 0.118 0.092 0.556540827966 gnomAD-4.0.0 6.57592E-06 None None None None N None 2.41418E-05 0 None 0 0 None 0 0 0 0 0
A/V 20163 Ig-120 84 None 0.141 None 0.22 N 0.57 0.239 0.57179433898 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.93751E-06 0 0
Y/C 20856 Ig-122 88 rs373867080 0.1923 -0.008 0.991 N 0.777 0.326 None gnomAD-2.1.1 5.72E-05 None None None None N None 4.96032E-04 1.1325E-04 None 0 0 None 0 None 0 0 0
Y/C 20856 Ig-122 88 rs373867080 0.1923 -0.008 0.991 N 0.777 0.326 None gnomAD-3.1.2 1.70933E-04 None None None None N None 6.2711E-04 0 0 0 0 None 0 0 0 0 0
Y/C 20856 Ig-122 88 rs373867080 0.1923 -0.008 0.991 N 0.777 0.326 None gnomAD-4.0.0 3.03734E-05 None None None None N None 6.14005E-04 5.00317E-05 None 0 0 None 0 0 0 0 0
Y/H 20856 Ig-122 88 rs2049698441 0.2874 None 0.908 N 0.725 0.323 0.438278051908 gnomAD-4.0.0 2.40064E-06 None None None None N None 1.26695E-04 0 None 0 0 None 0 0 0 0 0
T/A 21948 Ig-125 83 None 0.0716 None 0.835 N 0.58 0.259 0.317378411342 gnomAD-4.0.0 7.21209E-07 None None None None N None 0 0 None 0 0 None 0 0 9.31699E-07 0 0
T/S 21948 Ig-125 83 None 0.092 None 0.489 N 0.335 0.212 0.212008924253 gnomAD-4.0.0 7.21209E-07 None None None None N None 0 0 None 0 0 None 0 0 9.31699E-07 0 0
T/I 22346 Ig-126 82 None 0.3511 None 0.946 N 0.785 0.506 0.477219869099 gnomAD-4.0.0 6.84524E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99764E-07 0 0
T/N 22346 Ig-126 82 rs1283475494 0.2071 -0.08 0.973 N 0.753 0.435 0.432936702747 gnomAD-2.1.1 8.06E-06 None None None None I None 1.29249E-04 0 None 0 0 None 0 None 0 0 0
T/N 22346 Ig-126 82 rs1283475494 0.2071 -0.08 0.973 N 0.753 0.435 0.432936702747 gnomAD-4.0.0 2.05357E-06 None None None None I None 8.97344E-05 0 None 0 0 None 0 0 0 0 0
T/N 22635 Ig-127 76 None 0.0903 None 0.051 N 0.208 0.22 0.303123707472 gnomAD-4.0.0 3.42178E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49805E-06 0 0
T/S 22635 Ig-127 76 rs1465804178 0.0913 None 0.051 N 0.177 0.09 0.154104182512 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/S 22635 Ig-127 76 rs1465804178 0.0913 None 0.051 N 0.177 0.09 0.154104182512 gnomAD-4.0.0 6.57626E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47128E-05 0 0
H/D 23032 Ig-128 83 None 0.1456 None 0.166 N 0.389 0.235 0.223146558224 gnomAD-4.0.0 1.59271E-06 None None None None N None 0 0 None 0 2.78753E-05 None 0 0 0 0 0
H/L 23032 Ig-128 83 rs886055251 0.1092 None 0.166 N 0.441 0.317 0.432716982437 gnomAD-4.0.0 1.5927E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86E-06 0 0
H/Q 23032 Ig-128 83 rs1374973500 0.1337 0.175 0.491 N 0.412 0.117 0.270001397563 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
H/Q 23032 Ig-128 83 rs1374973500 0.1337 0.175 0.491 N 0.412 0.117 0.270001397563 gnomAD-4.0.0 6.84475E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9964E-07 0 0
F/S 23427 Ig-129 83 None 0.4919 None 0.204 N 0.55 0.382 0.681492719615 gnomAD-4.0.0 1.5917E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85936E-06 0 0
F/Y 23427 Ig-129 83 rs779382645 0.2496 0.043 0.981 N 0.576 0.254 0.571380689955 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
V/D 23718 Ig-130 82 None 0.2247 None 0.096 N 0.708 0.289 0.593429312994 gnomAD-4.0.0 6.84508E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15964E-05 0
V/I 23718 Ig-130 82 rs794729489 0.0703 None None N 0.149 0.035 0.382592752248 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
V/I 23718 Ig-130 82 rs794729489 0.0703 None None N 0.149 0.035 0.382592752248 gnomAD-4.0.0 1.23981E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.0982E-05 1.602E-05
V/L 23718 Ig-130 82 None 0.1435 None None N 0.149 0.056 0.47290127212 gnomAD-4.0.0 6.84421E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99609E-07 0 0
I/N 24114 Ig-131 86 None 0.1343 None 0.927 N 0.669 0.279 0.736317021544 gnomAD-4.0.0 2.74366E-06 None None None None N None 0 0 None 0 0 None 0 0 3.60412E-06 0 0
I/V 24114 Ig-131 86 None 0.0588 None 0.001 N 0.179 0.103 0.5073929853 gnomAD-4.0.0 1.60077E-06 None None None None N None 0 2.31E-05 None 0 0 None 0 0 0 0 0
F/Y 24511 Ig-132 81 rs1421171705 0.2509 -0.012 0.981 D 0.615 0.198 0.538050722575 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
F/Y 24511 Ig-132 81 rs1421171705 0.2509 -0.012 0.981 D 0.615 0.198 0.538050722575 gnomAD-4.0.0 1.59222E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43373E-05 0
F/Y 25593 Ig-135 80 rs547186080 0.2345 0.124 0.941 N 0.595 0.269 0.521438907708 gnomAD-2.1.1 7.15E-06 None None None None N None 0 0 None 0 0 None 0 None 0 7.84E-06 1.40687E-04
F/Y 25593 Ig-135 80 rs547186080 0.2345 0.124 0.941 N 0.595 0.269 0.521438907708 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
F/Y 25593 Ig-135 80 rs547186080 0.2345 0.124 0.941 N 0.595 0.269 0.521438907708 gnomAD-4.0.0 8.0579E-06 None None None None N None 0 0 None 0 0 None 0 0 1.01732E-05 0 1.60143E-05
S/F 25882 Ig-136 85 rs1300031734 0.0984 None 0.295 N 0.673 0.395 0.615709377971 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/F 25882 Ig-136 85 rs1300031734 0.0984 None 0.295 N 0.673 0.395 0.615709377971 gnomAD-4.0.0 6.58033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47137E-05 0 0
P/A 26278 Ig-137 86 rs1235411503 0.0765 -0.853 0.885 N 0.613 0.257 0.335164054921 gnomAD-4.0.0 1.60839E-06 None None None None N None 0 2.35106E-05 None 0 0 None 0 0 0 0 0
P/L 26278 Ig-137 86 None 0.1112 None 0.964 N 0.783 0.489 0.657223871714 gnomAD-4.0.0 2.7495E-06 None None None None N None 0 0 None 0 0 None 0 0 3.60551E-06 0 0
N/D 26964 Ig-139 85 rs886055242 0.0901 None None N 0.123 0.063 0.119812018005 gnomAD-4.0.0 6.84281E-07 None None None None N None 2.989E-05 0 None 0 0 None 0 0 0 0 0
N/H 26964 Ig-139 85 None 0.0737 None 0.47 N 0.424 0.071 0.194818534648 gnomAD-4.0.0 6.84281E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99528E-07 0 0
N/Y 26964 Ig-139 85 None 0.0918 None 0.73 N 0.6 0.125 0.38225645794 gnomAD-4.0.0 1.36856E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79906E-06 0 0
P/A 27361 Ig-140 84 rs56137800 0.0834 -0.742 0.998 N 0.737 0.335 None gnomAD-2.1.1 2.54402E-03 None None None None N None 0 0 None 0 3.56557E-02 None 2.61421E-04 None 0 7.83E-06 1.1236E-03
P/A 27361 Ig-140 84 rs56137800 0.0834 -0.742 0.998 N 0.737 0.335 None gnomAD-3.1.2 1.00613E-03 None None None None N None 0 0 0 0 2.80573E-02 None 0 0 1.47E-05 8.29531E-04 1.43267E-03
P/A 27361 Ig-140 84 rs56137800 0.0834 -0.742 0.998 N 0.737 0.335 None 1000 genomes 4.99201E-03 None None None None N None 0 0 None None 2.48E-02 0 None None None 0 None
P/A 27361 Ig-140 84 rs56137800 0.0834 -0.742 0.998 N 0.737 0.335 None gnomAD-4.0.0 8.86783E-04 None None None None N None 0 0 None 0 2.89525E-02 None 0 1.65071E-04 1.01719E-05 3.29402E-04 1.44046E-03
F/C 27758 Ig-141 83 None 0.7065 None 1.0 N 0.879 0.577 0.855030217213 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
F/L 27758 Ig-141 83 rs188323108 0.9679 -1.013 0.999 N 0.586 0.438 0.552698843619 gnomAD-2.1.1 3.4155E-04 None None None None N None 0 0 None 0 4.89532E-03 None 0 None 0 0 1.41563E-04
F/L 27758 Ig-141 83 rs188323108 0.9679 -1.013 0.999 N 0.586 0.438 0.552698843619 gnomAD-3.1.2 7.23E-05 None None None None N None 0 6.56E-05 0 0 1.93199E-03 None 0 0 0 0 0
F/L 27758 Ig-141 83 rs188323108 0.9679 -1.013 0.999 N 0.586 0.438 0.552698843619 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 2E-03 0 None None None 0 None
F/L 27758 Ig-141 83 rs188323108 0.9679 -1.013 0.999 N 0.586 0.438 0.552698843619 gnomAD-4.0.0 6.07534E-05 None None None None N None 0 3.33823E-05 None 0 1.94674E-03 None 0 0 0 0 1.44161E-04
F/S 27758 Ig-141 83 None 0.6082 None 1.0 N 0.874 0.498 0.754480948551 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/S 28047 Ig-142 85 rs1390232115 0.1337 -0.799 None N 0.209 0.109 0.228597637076 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
P/S 28047 Ig-142 85 rs1390232115 0.1337 -0.799 None N 0.209 0.109 0.228597637076 gnomAD-4.0.0 1.59227E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85933E-06 0 0
A/P 28442 Ig-143 85 None 0.1235 None 0.908 N 0.861 0.379 0.376570364461 gnomAD-4.0.0 1.59164E-06 None None None None N None 0 0 None 0 2.77994E-05 None 0 0 0 0 0
A/T 28442 Ig-143 85 rs1440588329 0.096 None 0.01 N 0.389 0.076 0.134241683229 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
A/T 28442 Ig-143 85 rs1440588329 0.096 None 0.01 N 0.389 0.076 0.134241683229 gnomAD-4.0.0 6.57091E-06 None None None None N None 0 6.5505E-05 None 0 0 None 0 0 0 0 0
T/S 28837 Ig-144 83 None 0.1181 None 0.992 N 0.492 0.245 0.335661160332 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/S 28837 Ig-144 83 None 0.1181 None 0.992 N 0.492 0.245 0.335661160332 gnomAD-4.0.0 6.56763E-06 None None None None N None 2.40616E-05 0 None 0 0 None 0 0 0 0 0
F/L 29129 Ig-145 85 rs1335641292 0.6056 None 0.004 N 0.217 0.198 0.435915822735 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
F/L 29129 Ig-145 85 rs1335641292 0.6056 None 0.004 N 0.217 0.198 0.435915822735 gnomAD-4.0.0 1.8596E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54264E-06 0 0
T/S 29925 Ig-147 84 rs780250655 0.1266 -0.735 0.001 N 0.171 0.111 0.301455362545 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
T/S 29925 Ig-147 84 rs780250655 0.1266 -0.735 0.001 N 0.171 0.111 0.301455362545 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/A 30611 Ig-149 80 None 0.1115 None 0.027 N 0.457 0.24 0.281381271821 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 30611 Ig-149 80 rs769702560 0.1379 -0.068 0.027 N 0.367 0.137 0.241664281697 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 3.34E-05 None 0 0 0
E/K 30611 Ig-149 80 rs769702560 0.1379 -0.068 0.027 N 0.367 0.137 0.241664281697 gnomAD-4.0.0 1.37352E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.33465E-05 0
T/R 31008 Ig-150 82 rs1287048789 0.5956 None 0.964 N 0.684 0.542 0.562354153293 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
T/R 31008 Ig-150 82 rs1287048789 0.5956 None 0.964 N 0.684 0.542 0.562354153293 gnomAD-4.0.0 6.57281E-06 None None None None N None 0 6.55394E-05 None 0 0 None 0 0 0 0 0
S/G 31300 Ig-151 83 None 0.1115 None 0.01 N 0.267 0.303 0.303123707472 gnomAD-4.0.0 1.59106E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8578E-06 0 0
T/I 32097 Ig-153 81 rs1559126683 0.2174 None 0.884 N 0.385 0.37 0.474643619859 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
T/I 32391 Ig-154 85 rs1353755396 0.112 0.055 0.166 N 0.523 0.16 0.296329037015 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
T/I 32391 Ig-154 85 rs1353755396 0.112 0.055 0.166 N 0.523 0.16 0.296329037015 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
T/I 32391 Ig-154 85 rs1353755396 0.112 0.055 0.166 N 0.523 0.16 0.296329037015 gnomAD-4.0.0 4.33914E-06 None None None None N None 1.33583E-05 0 None 0 0 None 0 0 5.08718E-06 0 0
Y/C 32787 Ig-155 80 rs1419941913 0.1501 None 1.0 N 0.795 0.482 0.66614110018 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
Y/C 32787 Ig-155 80 rs1419941913 0.1501 None 1.0 N 0.795 0.482 0.66614110018 gnomAD-4.0.0 6.57082E-06 None None None None I None 0 6.54536E-05 None 0 0 None 0 0 0 0 0
Y/F 32787 Ig-155 80 None 0.1091 None 0.999 N 0.581 0.465 0.568962582336 gnomAD-4.0.0 3.18253E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71608E-06 0 0
S/N 33185 Ig-156 85 rs1377798768 0.2812 None 0.998 N 0.671 0.366 0.456738291233 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/N 33185 Ig-156 85 rs1377798768 0.2812 None 0.998 N 0.671 0.366 0.456738291233 gnomAD-4.0.0 3.71827E-06 None None None None N None 4.00491E-05 0 None 0 0 None 0 0 2.54284E-06 0 0
S/R 33185 Ig-156 85 None 0.6466 None 1.0 D 0.885 0.529 0.367612772649 gnomAD-4.0.0 1.59134E-06 None None None None N None 5.65739E-05 0 None 0 0 None 0 0 0 0 0
I/T 33282 Ig-157 80 rs747546215 0.0895 -0.722 None N 0.219 0.135 None gnomAD-2.1.1 4.6E-06 None None None None N None 6.79E-05 0 None 0 0 None 0 None 0 0 0
I/T 33282 Ig-157 80 rs747546215 0.0895 -0.722 None N 0.219 0.135 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
I/T 33282 Ig-157 80 rs747546215 0.0895 -0.722 None N 0.219 0.135 None gnomAD-4.0.0 5.44553E-06 None None None None N None 7.0028E-05 0 None 0 0 None 0 0 0 0 0
T/S 33582 Ig-158 87 rs1289282264 0.2594 -0.283 0.98 N 0.591 0.268 0.447803500395 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/S 33582 Ig-158 87 rs1289282264 0.2594 -0.283 0.98 N 0.591 0.268 0.447803500395 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/S 33582 Ig-158 87 rs1289282264 0.2594 -0.283 0.98 N 0.591 0.268 0.447803500395 gnomAD-4.0.0 6.57281E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47011E-05 0 0
T/I 33681 Ig-159 86 None 0.5999 None 1.0 N 0.893 0.531 0.675958104092 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
Q/R 34448 Ig-162 86 None 0.56 None 0.98 N 0.627 0.379 0.21279746466 gnomAD-4.0.0 2.73658E-06 None None None None N None 2.98704E-05 0 None 0 2.51915E-05 None 0 0 0 0 3.31268E-05
Y/C 35026 Ig-163 85 rs757648598 0.7502 0.16 1.0 D 0.804 0.348 0.671143324981 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
Y/C 35026 Ig-163 85 rs757648598 0.7502 0.16 1.0 D 0.804 0.348 0.671143324981 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
Y/C 35026 Ig-163 85 rs757648598 0.7502 0.16 1.0 D 0.804 0.348 0.671143324981 gnomAD-4.0.0 7.43567E-06 None None None None N None 0 0 None 0 0 None 0 0 1.01705E-05 0 0
E/A 35213 Ig-164 85 rs748652325 0.1104 -1.233 None N 0.206 0.127 0.291694819147 gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
E/A 35213 Ig-164 85 rs748652325 0.1104 -1.233 None N 0.206 0.127 0.291694819147 gnomAD-4.0.0 4.10482E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69817E-06 3.47794E-05 0
E/K 35213 Ig-164 85 None 0.0954 None None N 0.164 0.099 0.184867976434 gnomAD-4.0.0 3.18176E-06 None None None None N None 0 0 None 0 5.54477E-05 None 0 0 0 0 0
N/S 35371 Ig-165 86 rs1200663369 0.0601 -0.482 None N 0.207 0.065 0.0716867268079 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
S/I 35504 Ig-166 85 None 0.1983 None 0.857 D 0.689 0.374 0.774508433761 gnomAD-4.0.0 6.91209E-07 None None None None N None 0 0 None 0 0 None 0 0 9.02156E-07 0 0
S/N 35504 Ig-166 85 None 0.1647 None 0.011 N 0.331 0.143 0.176091768786 gnomAD-4.0.0 6.91209E-07 None None None None N None 0 0 None 0 0 None 0 0 9.02156E-07 0 0
S/T 35504 Ig-166 85 rs575070622 0.0944 -0.106 0.458 N 0.497 0.112 0.221734844693 gnomAD-2.1.1 6.75E-05 None None None None N None 0 0 None 0 0 None 0 None 8.05E-05 1.28178E-04 0
S/T 35504 Ig-166 85 rs575070622 0.0944 -0.106 0.458 N 0.497 0.112 0.221734844693 gnomAD-3.1.2 7.23E-05 None None None None N None 0 0 0 0 0 None 9.43E-05 0 1.46985E-04 0 0
S/T 35504 Ig-166 85 rs575070622 0.0944 -0.106 0.458 N 0.497 0.112 0.221734844693 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
S/T 35504 Ig-166 85 rs575070622 0.0944 -0.106 0.458 N 0.497 0.112 0.221734844693 gnomAD-4.0.0 3.43962E-05 None None None None N None 0 0 None 0 0 None 3.12891E-05 0 4.33496E-05 0 3.22935E-05
Q/R 35689 Ig-167 83 rs1451601178 0.1367 -0.004 0.324 N 0.486 0.236 0.227934060464 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
Q/R 35689 Ig-167 83 rs1451601178 0.1367 -0.004 0.324 N 0.486 0.236 0.227934060464 gnomAD-4.0.0 1.36872E-05 None None None None N None 0 0 None 0 0 None 0 0 1.61917E-05 0 3.31389E-05
T/I 35786 Ig-168 85 rs749086389 0.3607 -0.082 1.0 N 0.883 0.519 None gnomAD-2.1.1 1.43E-05 None None None None I None 1.24008E-04 0 None 0 5.12E-05 None 0 None 0 0 0
T/I 35786 Ig-168 85 rs749086389 0.3607 -0.082 1.0 N 0.883 0.519 None gnomAD-3.1.2 5.91E-05 None None None None I None 2.17098E-04 0 0 0 0 None 0 0 0 0 0
T/I 35786 Ig-168 85 rs749086389 0.3607 -0.082 1.0 N 0.883 0.519 None gnomAD-4.0.0 1.30121E-05 None None None None I None 1.99872E-04 0 None 0 2.22816E-05 None 0 0 2.54275E-06 0 3.20102E-05
T/A 35983 Ig-169 87 rs764418855 0.1278 -0.987 0.454 D 0.46 0.222 0.197625483188 gnomAD-2.1.1 4.02E-06 None None None -0.8(OBSL1) -0.08(OBSCN) N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/A 35983 Ig-169 87 rs764418855 0.1278 -0.987 0.454 D 0.46 0.222 0.197625483188 gnomAD-4.0.0 6.84266E-07 None None None -0.8(OBSL1) -0.08(OBSCN) N None 0 0 None 0 0 None 0 0 0 1.16001E-05 0
T/P 35983 Ig-169 87 rs764418855 0.4435 -0.702 0.966 N 0.625 0.492 0.479744053436 gnomAD-2.1.1 1.21E-05 None None None -0.992(OBSL1) -0.091(OBSCN) N None 0 0 None 0 0 None 0 None 0 1.77E-05 1.66389E-04
T/P 35983 Ig-169 87 rs764418855 0.4435 -0.702 0.966 N 0.625 0.492 0.479744053436 gnomAD-4.0.0 4.78986E-06 None None None -0.992(OBSL1) -0.091(OBSCN) N None 0 2.23654E-05 None 0 0 None 0 0 5.39696E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.