Structural position:

  • Domain Type: Ig
  • Aligned Position: 2
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand A

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
T/A 7 Ig-1 2 rs752073551 0.0993 -1.0 0.017 N 0.385 0.209 0.183819452728 gnomAD-2.1.1 7.97E-06 None None None -0.829(TCAP) N None 0 0 None 0 0 None 0 None 4.62E-05 8.82E-06 0
T/A 7 Ig-1 2 rs752073551 0.0993 -1.0 0.017 N 0.385 0.209 0.183819452728 gnomAD-4.0.0 1.59103E-06 None None None -0.829(TCAP) N None 0 0 None 0 0 None 1.88182E-05 0 0 0 0
T/K 7 Ig-1 2 rs761344572 0.2277 -0.251 0.915 N 0.48 0.397 0.379366414296 gnomAD-2.1.1 3.98E-06 None None None -1.585(TCAP) N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/K 7 Ig-1 2 rs761344572 0.2277 -0.251 0.915 N 0.48 0.397 0.379366414296 gnomAD-4.0.0 1.36833E-06 None None None -1.585(TCAP) N None 2.98757E-05 0 None 0 0 None 0 0 0 1.15988E-05 0
T/M 7 Ig-1 2 rs761344572 0.1336 -0.151 0.327 N 0.355 0.251 0.49118058892 gnomAD-2.1.1 1.2E-05 None None None -0.053(TCAP) N None 0 2.89E-05 None 0 0 None 3.27E-05 None 0 8.82E-06 0
T/M 7 Ig-1 2 rs761344572 0.1336 -0.151 0.327 N 0.355 0.251 0.49118058892 gnomAD-4.0.0 1.29992E-05 None None None -0.053(TCAP) N None 0 2.23644E-05 None 0 2.51965E-05 None 0 0 9.89314E-06 3.47963E-05 4.96952E-05
T/R 7 Ig-1 2 None 0.1823 None 0.967 N 0.513 0.427 0.531245695338 gnomAD-4.0.0 6.84166E-07 None None None -1.392(TCAP) N None 0 0 None 0 2.51965E-05 None 0 0 0 0 0
N/H 105 Ig-2 2 rs780972429 0.195 -0.682 1.0 N 0.615 0.347 0.350307294319 gnomAD-2.1.1 1.21E-05 None None None -0.263(TCAP) N None 0 0 None 0 0 None 1.00341E-04 None 0 0 0
N/H 105 Ig-2 2 rs780972429 0.195 -0.682 1.0 N 0.615 0.347 0.350307294319 gnomAD-4.0.0 2.74527E-06 None None None -0.263(TCAP) N None 0 0 None 0 0 None 0 0 0 2.33661E-05 3.32469E-05
N/K 105 Ig-2 2 None 0.5599 None 0.999 N 0.537 0.196 0.229924730088 gnomAD-4.0.0 6.86165E-07 None None None -0.976(TCAP) N None 0 0 None 0 0 None 0 0 9.01192E-07 0 0
G/V 1292 Ig-5 2 None 0.1809 None 0.89 N 0.613 0.357 0.654740151078 gnomAD-4.0.0 1.20083E-06 None None None None N None 0 0 None 1.94401E-04 0 None 0 0 0 0 0
V/D 1458 Ig-6 2 None 0.9241 None 1.0 N 0.768 0.691 0.880924136359 gnomAD-4.0.0 1.36822E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79868E-06 0 0
V/G 1458 Ig-6 2 rs1164246536 0.7516 -0.8 1.0 D 0.742 0.588 0.920042922032 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
V/G 1458 Ig-6 2 rs1164246536 0.7516 -0.8 1.0 D 0.742 0.588 0.920042922032 gnomAD-3.1.2 1.31E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
V/G 1458 Ig-6 2 rs1164246536 0.7516 -0.8 1.0 D 0.742 0.588 0.920042922032 gnomAD-4.0.0 4.33734E-06 None None None None I None 1.33543E-05 0 None 0 0 None 0 0 4.23743E-06 0 1.60046E-05
M/I 1557 Ig-7 2 rs139192633 0.1044 0.324 None N 0.178 0.105 0.321393169273 gnomAD-2.1.1 3.08727E-04 None None None None N None 3.04463E-03 2.54439E-04 None 0 0 None 0 None 0 0 2.78396E-04
M/I 1557 Ig-7 2 rs139192633 0.1044 0.324 None N 0.178 0.105 0.321393169273 gnomAD-3.1.2 8.67439E-04 None None None None N None 2.89533E-03 6.5445E-04 0 0 0 None 0 0 0 0 9.56938E-04
M/I 1557 Ig-7 2 rs139192633 0.1044 0.324 None N 0.178 0.105 0.321393169273 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
M/I 1557 Ig-7 2 rs139192633 0.1044 0.324 None N 0.178 0.105 0.321393169273 gnomAD-4.0.0 1.86503E-04 None None None None N None 3.53154E-03 3.16667E-04 None 0 2.23105E-05 None 0 0 0 2.19597E-05 2.24022E-04
M/T 1557 Ig-7 2 rs1270728521 0.071 0.505 0.001 N 0.271 0.121 0.559923220125 gnomAD-4.0.0 6.00161E-06 None None None None N None 1.90042E-04 0 None 0 0 None 0 0 2.625E-06 0 0
D/H 1842 Ig-9 2 None 0.4168 None 0.998 N 0.487 0.43 0.388174495139 gnomAD-4.0.0 6.84204E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65579E-05
D/N 1842 Ig-9 2 rs1469586209 0.1302 0.063 0.939 N 0.415 0.25 0.405150804464 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
D/N 1842 Ig-9 2 rs1469586209 0.1302 0.063 0.939 N 0.415 0.25 0.405150804464 gnomAD-4.0.0 6.84204E-07 None None None None N None 0 2.23614E-05 None 0 0 None 0 0 0 0 0
K/E 2079 Ig-10 2 None 0.8173 None 0.989 N 0.508 0.394 0.494299846589 gnomAD-4.0.0 1.59057E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85651E-06 0 0
K/R 2079 Ig-10 2 rs1395240027 0.114 -0.066 0.217 N 0.185 0.251 0.353761421236 gnomAD-2.1.1 3.18E-05 None None None None I None 0 1.17924E-03 None 0 0 None 0 None 0 0 0
K/R 2079 Ig-10 2 rs1395240027 0.114 -0.066 0.217 N 0.185 0.251 0.353761421236 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
K/R 2079 Ig-10 2 rs1395240027 0.114 -0.066 0.217 N 0.185 0.251 0.353761421236 gnomAD-4.0.0 6.57013E-06 None None None None I None 0 6.54707E-05 None 0 0 None 0 0 0 0 0
E/G 2268 Ig-12 2 rs1288686465 0.2066 -0.585 0.999 D 0.627 0.618 0.580444438771 gnomAD-2.1.1 3.18E-05 None None None None N None 1.14732E-04 0 None 0 0 None 0 None 0 0 0
E/Q 2268 Ig-12 2 None 0.155 None 0.999 N 0.646 0.303 0.29385284311 gnomAD-4.0.0 1.59429E-06 None None None None N None 0 0 None 0 0 None 0 2.41313E-04 0 0 0
D/N 2446 Ig-14 2 None 0.0949 None 0.001 N 0.264 0.081 0.225902525712 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/E 2534 Ig-15 2 rs767167863 0.0996 0.292 0.012 N 0.153 0.321 0.224531998449 gnomAD-2.1.1 1.2E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 1.77E-05 0
K/E 2534 Ig-15 2 rs767167863 0.0996 0.292 0.012 N 0.153 0.321 0.224531998449 gnomAD-4.0.0 6.36343E-06 None None None None N None 0 2.28728E-05 None 0 0 None 0 0 8.57016E-06 0 0
H/Q 2883 Ig-19 2 rs763935915 0.2208 0.374 0.029 N 0.159 0.285 0.119812018005 gnomAD-2.1.1 2.79E-05 None None None None N None 0 0 None 0 0 None 2.28654E-04 None 0 0 0
H/Q 2883 Ig-19 2 rs763935915 0.2208 0.374 0.029 N 0.159 0.285 0.119812018005 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06868E-04 0
H/Q 2883 Ig-19 2 rs763935915 0.2208 0.374 0.029 N 0.159 0.285 0.119812018005 gnomAD-4.0.0 9.2936E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.64672E-04 0
H/R 2883 Ig-19 2 rs753833148 0.1061 -0.489 0.002 N 0.143 0.298 0.15556083564 gnomAD-2.1.1 2E-05 None None None None N None 0 1.15781E-04 None 0 5.45E-05 None 0 None 0 0 0
H/R 2883 Ig-19 2 rs753833148 0.1061 -0.489 0.002 N 0.143 0.298 0.15556083564 gnomAD-3.1.2 1.97E-05 None None None None N None 0 6.54E-05 0 0 0 None 0 0 1.47E-05 2.07125E-04 0
H/R 2883 Ig-19 2 rs753833148 0.1061 -0.489 0.002 N 0.143 0.298 0.15556083564 gnomAD-4.0.0 1.3011E-05 None None None None N None 0 1.16667E-04 None 0 4.45653E-05 None 0 0 2.54235E-06 5.48944E-05 6.40123E-05
M/I 2970 Ig-20 2 None 0.3066 None 0.019 N 0.265 0.133 0.414281671643 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
M/T 2970 Ig-20 2 None 0.1926 None 0.175 N 0.38 0.33 None gnomAD-4.0.0 1.59137E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85664E-06 0 0
E/Q 3059 Ig-21 2 None 0.4166 None 0.89 N 0.381 0.326 0.219573609325 gnomAD-4.0.0 1.59075E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.0217E-05
E/V 3059 Ig-21 2 rs727504501 0.5841 0.011 0.942 N 0.545 0.508 0.62999039529 gnomAD-2.1.1 5.32E-05 None None None None N None 0 2.83E-05 None 0 6.54846E-04 None 3.27E-05 None 0 0 0
E/V 3059 Ig-21 2 rs727504501 0.5841 0.011 0.942 N 0.545 0.508 0.62999039529 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 5.76923E-04 None 0 0 0 0 0
E/V 3059 Ig-21 2 rs727504501 0.5841 0.011 0.942 N 0.545 0.508 0.62999039529 gnomAD-4.0.0 2.78823E-05 None None None None N None 0 1.66733E-05 None 0 6.9147E-04 None 0 0 0 1.09784E-05 1.92049E-04
R/C 3148 Ig-22 2 rs372196051 0.6248 -0.235 1.0 N 0.761 0.331 None gnomAD-2.1.1 1.77E-05 None None None None N None 0 2.82E-05 None 0 0 None 0 None 0 3.11E-05 0
R/C 3148 Ig-22 2 rs372196051 0.6248 -0.235 1.0 N 0.761 0.331 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
R/C 3148 Ig-22 2 rs372196051 0.6248 -0.235 1.0 N 0.761 0.331 None gnomAD-4.0.0 3.65561E-05 None None None None N None 0 1.66661E-05 None 0 0 None 0 0 4.83054E-05 0 1.60046E-05
R/H 3148 Ig-22 2 rs368786036 0.2607 -0.944 1.0 N 0.764 0.267 None gnomAD-2.1.1 2.79E-05 None None None None N None 6.15E-05 0 None 0 0 None 1.30659E-04 None 0 1.76E-05 0
R/H 3148 Ig-22 2 rs368786036 0.2607 -0.944 1.0 N 0.764 0.267 None gnomAD-3.1.2 5.26E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 8.82E-05 2.07211E-04 0
R/H 3148 Ig-22 2 rs368786036 0.2607 -0.944 1.0 N 0.764 0.267 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
R/H 3148 Ig-22 2 rs368786036 0.2607 -0.944 1.0 N 0.764 0.267 None gnomAD-4.0.0 5.6378E-05 None None None None N None 5.32992E-05 0 None 0 2.22797E-05 None 0 0 6.44067E-05 7.68555E-05 4.79954E-05
R/L 3148 Ig-22 2 rs368786036 0.6255 0.416 1.0 N 0.624 0.284 0.254761474806 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/L 3148 Ig-22 2 rs368786036 0.6255 0.416 1.0 N 0.624 0.284 0.254761474806 gnomAD-4.0.0 8.20898E-06 None None None None N None 0 0 None 0 0 None 0 0 3.5972E-06 3.47794E-05 8.27897E-05
A/P 3346 Ig-24 2 None 0.7645 None 0.484 N 0.351 0.279 0.3691244813 gnomAD-4.0.0 1.36819E-06 None None None None N None 0 0 None 0 5.04337E-05 None 0 0 0 0 0
A/T 3346 Ig-24 2 None 0.0625 None None N 0.239 0.063 0.256283259241 gnomAD-4.0.0 6.84097E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99315E-07 0 0
S/G 3466 Ig-25 2 None 0.1311 None None None None 0.141 None gnomAD-4.0.0 1.60981E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.05455E-05
S/N 3466 Ig-25 2 None 0.096 None None None None 0.09 None gnomAD-4.0.0 1.60964E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.45345E-05 0
S/R 3466 Ig-25 2 rs760613487 0.2198 0.308 None None None 0.055 None gnomAD-2.1.1 4.09E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.02E-06 0
S/T 3466 Ig-25 2 rs533542171 0.066 0.245 None None None 0.099 None gnomAD-2.1.1 4.1E-06 None None None None N None 6.51E-05 0 None 0 0 None 0 None 0 0 0
S/T 3466 Ig-25 2 rs533542171 0.066 0.245 None None None 0.099 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/T 3466 Ig-25 2 rs533542171 0.066 0.245 None None None 0.099 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
S/T 3466 Ig-25 2 rs533542171 0.066 0.245 None None None 0.099 None gnomAD-4.0.0 6.56711E-06 None None None None N None 2.40604E-05 0 None 0 0 None 0 0 0 0 0
K/E 3661 Ig-26 2 rs749398811 0.0833 0.226 None None None 0.095 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/N 3661 Ig-26 2 rs368025093 0.195 None None None None 0.084 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/N 3661 Ig-26 2 rs368025093 0.195 None None None None 0.084 None gnomAD-4.0.0 3.0444E-06 None None None None I None 5.23049E-05 0 None 0 0 None 0 0 0 0 0
K/T 3661 Ig-26 2 rs2087010356 0.1091 None None None None 0.09 None gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 3821 Ig-27 2 rs867402675 0.0564 None None N 0.061 0.087 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/V 3821 Ig-27 2 rs867402675 0.0564 None None N 0.061 0.087 None gnomAD-4.0.0 1.3015E-05 None None None None I None 3.99989E-05 0 None 0 2.90282E-04 None 0 0 1.69536E-06 3.29388E-05 0
H/P 3939 Ig-28 2 None 0.4716 None 0.013 N 0.309 0.12 None gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/Y 3939 Ig-28 2 None 0.0485 None None N 0.097 0.115 None gnomAD-4.0.0 1.59108E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
M/K 4607 Ig-29 2 rs1391877719 0.1291 None 0.001 N 0.277 0.085 None gnomAD-4.0.0 1.59119E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85796E-06 0 0
M/V 4607 Ig-29 2 rs371275648 0.0498 -1.154 None N 0.077 0.139 None gnomAD-2.1.1 8.93E-05 None None None None N None 4.13E-05 0 None 0 0 None 0 None 0 1.87832E-04 0
M/V 4607 Ig-29 2 rs371275648 0.0498 -1.154 None N 0.077 0.139 None gnomAD-3.1.2 5.91E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.02899E-04 0 0
M/V 4607 Ig-29 2 rs371275648 0.0498 -1.154 None N 0.077 0.139 None gnomAD-4.0.0 7.86978E-05 None None None None N None 2.66923E-05 0 None 0 0 None 3.12432E-05 0 1.00862E-04 0 6.4041E-05
V/A 4701 Ig-30 2 rs763929922 0.2491 -1.117 0.76 N 0.462 0.296 0.519241965532 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 3.3E-05 None 0 0 0
V/A 4701 Ig-30 2 rs763929922 0.2491 -1.117 0.76 N 0.462 0.296 0.519241965532 gnomAD-4.0.0 1.59656E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43691E-05 0
V/L 4701 Ig-30 2 rs1306703274 0.2088 -0.435 0.76 N 0.396 0.208 0.500488203797 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
V/L 4701 Ig-30 2 rs1306703274 0.2088 -0.435 0.76 N 0.396 0.208 0.500488203797 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/L 4701 Ig-30 2 rs1306703274 0.2088 -0.435 0.76 N 0.396 0.208 0.500488203797 gnomAD-4.0.0 2.57038E-06 None None None None N None 1.69302E-05 0 None 0 0 None 0 0 2.40189E-06 0 0
T/A 4796 Ig-31 2 rs780971372 0.0617 -0.663 None N 0.121 0.07 0.130388298395 gnomAD-2.1.1 1.8E-05 None None None None I None 0 0 None 0 0 None 0 None 0 3.86E-05 0
T/A 4796 Ig-31 2 rs780971372 0.0617 -0.663 None N 0.121 0.07 0.130388298395 gnomAD-4.0.0 1.67824E-05 None None None None I None 3.10347E-05 0 None 0 0 None 0 3.57015E-04 1.45896E-05 0 8.48522E-05
H/R 4889 Ig-32 2 rs766842583 0.0695 -0.694 None N 0.154 0.143 0.0666544352282 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
H/R 4889 Ig-32 2 rs766842583 0.0695 -0.694 None N 0.154 0.143 0.0666544352282 gnomAD-4.0.0 2.73702E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99465E-07 3.47818E-05 0
H/Y 4889 Ig-32 2 None 0.0897 None 0.106 N 0.454 0.19 0.201204373187 gnomAD-4.0.0 1.59151E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
S/T 4982 Ig-33 2 rs775173260 0.0706 0.122 None N 0.165 0.049 0.0297737177859 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/T 4982 Ig-33 2 rs775173260 0.0706 0.122 None N 0.165 0.049 0.0297737177859 gnomAD-4.0.0 6.5697E-06 None None None None N None 2.41208E-05 0 None 0 0 None 0 0 0 0 0
S/F 5076 Ig-34 2 None 0.1451 None 0.984 N 0.627 0.275 0.679362012665 gnomAD-4.0.0 1.71952E-06 None None None None N None 0 0 None 0 0 None 0 0 3.05308E-06 0 0
T/N 5169 Ig-35 2 rs761475085 0.1035 None 0.379 N 0.288 0.154 0.346085882481 gnomAD-4.0.0 1.6477E-06 None None None None N None 0 0 None 0 0 None 1.89459E-05 0 0 0 0
T/S 5169 Ig-35 2 rs761475085 0.0815 -0.496 0.007 N 0.11 0.149 0.168933306366 gnomAD-2.1.1 4.17E-06 None None None None N None 0 0 None 0 0 None 3.53E-05 None 0 0 0
T/S 5169 Ig-35 2 rs761475085 0.0815 -0.496 0.007 N 0.11 0.149 0.168933306366 gnomAD-4.0.0 1.6477E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.48854E-05 0
K/I 5262 Ig-36 2 None 0.1966 None 0.968 N 0.659 0.262 0.325263233342 gnomAD-4.0.0 1.37188E-06 None None None None N None 0 0 None 0 0 None 0 0 1.8031E-06 0 0
K/R 5262 Ig-36 2 rs761927504 0.0709 0.205 0.026 N 0.258 0.081 0.18274738541 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
K/R 5262 Ig-36 2 rs761927504 0.0709 0.205 0.026 N 0.258 0.081 0.18274738541 gnomAD-4.0.0 6.85938E-07 None None None None N None 0 0 None 0 2.52321E-05 None 0 0 0 0 0
F/L 5358 Ig-37 2 None 0.5194 None None N 0.107 0.062 0.18995819373 gnomAD-4.0.0 1.38517E-06 None None None None N None 0 0 None 0 0 None 0 0 9.08041E-07 1.19832E-05 0
S/C 5451 Ig-38 2 None 0.1096 None 0.004 N 0.179 0.445 0.378847511475 gnomAD-4.0.0 4.87252E-06 None None None None N None 0 0 None 0 0 None 0 0 6.36383E-06 0 0
S/G 5451 Ig-38 2 rs760722200 0.1094 -0.591 0.183 N 0.207 0.341 0.227934060464 gnomAD-2.1.1 1.94E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.18E-05 0
S/G 5451 Ig-38 2 rs760722200 0.1094 -0.591 0.183 N 0.207 0.341 0.227934060464 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
S/G 5451 Ig-38 2 rs760722200 0.1094 -0.591 0.183 N 0.207 0.341 0.227934060464 gnomAD-4.0.0 2.70654E-05 None None None None N None 0 0 None 0 0 None 0 1.68805E-04 3.59596E-05 0 0
S/N 5451 Ig-38 2 rs1365352148 0.1355 0.021 0.351 D 0.207 0.161 0.223847106136 gnomAD-2.1.1 4.42E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.6E-06 0
S/N 5451 Ig-38 2 rs1365352148 0.1355 0.021 0.351 D 0.207 0.161 0.223847106136 gnomAD-4.0.0 6.96205E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.21942E-05 0
T/K 5544 Ig-39 2 rs751511581 0.1084 -0.026 0.001 N 0.263 0.079 0.134241683229 gnomAD-2.1.1 4.18E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.17E-06 0
T/K 5544 Ig-39 2 rs751511581 0.1084 -0.026 0.001 N 0.263 0.079 0.134241683229 gnomAD-4.0.0 1.62648E-06 None None None None N None 0 0 None 0 0 None 0 0 2.92164E-06 0 0
Y/N 5638 Ig-40 2 rs777950405 0.1109 -0.192 0.642 N 0.458 0.259 0.405560941015 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 3.34E-05 None 0 0 0
Y/N 5638 Ig-40 2 rs777950405 0.1109 -0.192 0.642 N 0.458 0.259 0.405560941015 gnomAD-4.0.0 1.61146E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44504E-05 0
S/P 5731 Ig-41 2 rs1578170411 0.786 None None N 0.173 0.179 0.0986583533028 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 5824 Ig-42 2 rs750512727 0.0708 -0.461 0.334 N 0.404 0.119 0.0954503805726 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/A 5824 Ig-42 2 rs750512727 0.0708 -0.461 0.334 N 0.404 0.119 0.0954503805726 gnomAD-4.0.0 2.0537E-06 None None None None N None 0 2.23914E-05 None 0 0 None 0 0 1.79972E-06 0 0
Y/H 6013 Ig-44 2 rs548015673 0.118 0.654 0.989 N 0.526 0.23 None gnomAD-2.1.1 5.15E-05 None None None None N None 6.68E-05 0 None 0 0 None 0 None 0 1.0396E-04 0
Y/H 6013 Ig-44 2 rs548015673 0.118 0.654 0.989 N 0.526 0.23 None gnomAD-3.1.2 5.26E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.02911E-04 0 0
Y/H 6013 Ig-44 2 rs548015673 0.118 0.654 0.989 N 0.526 0.23 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
Y/H 6013 Ig-44 2 rs548015673 0.118 0.654 0.989 N 0.526 0.23 None gnomAD-4.0.0 1.17805E-04 None None None None N None 2.69143E-05 0 None 0 0 None 0 0 1.56307E-04 0 4.86271E-05
T/I 6200 Ig-46 2 rs1046417798 0.0951 None None N 0.238 0.067 0.21737058555 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/P 6293 Ig-47 2 rs1560769509 0.8956 None 0.921 N 0.379 0.387 0.305086939656 gnomAD-4.0.0 2.10097E-06 None None None None N None 0 0 None 0 0 None 0 0 1.82503E-06 0 1.69733E-05
Q/E 6386 Ig-48 2 rs1578126437 0.0863 None 0.334 N 0.314 0.171 0.26169431596 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
Q/E 6386 Ig-48 2 rs1578126437 0.0863 None 0.334 N 0.314 0.171 0.26169431596 gnomAD-4.0.0 6.57376E-06 None None None None N None 2.41324E-05 0 None 0 0 None 0 0 0 0 0
Q/H 6386 Ig-48 2 rs727504206 0.1522 None 0.009 N 0.179 0.195 0.257292322809 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
Q/H 6386 Ig-48 2 rs727504206 0.1522 None 0.009 N 0.179 0.195 0.257292322809 gnomAD-4.0.0 6.57212E-06 None None None None N None 0 6.55394E-05 None 0 0 None 0 0 0 0 0
Q/P 6386 Ig-48 2 rs1487828646 0.7368 0.274 0.963 N 0.363 0.351 0.388970301349 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
Q/P 6386 Ig-48 2 rs1487828646 0.7368 0.274 0.963 N 0.363 0.351 0.388970301349 gnomAD-4.0.0 2.76379E-06 None None None None N None 0 0 None 0 0 None 0 0 2.72568E-06 0 1.67504E-05
S/P 6482 Ig-49 2 rs1560758702 0.9124 None 0.989 N 0.349 0.414 0.331619326243 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/N 6575 Ig-50 2 rs560328343 0.157 0.125 0.999 N 0.503 0.302 0.346768085243 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/N 6575 Ig-50 2 rs560328343 0.157 0.125 0.999 N 0.503 0.302 0.346768085243 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
S/N 6575 Ig-50 2 rs560328343 0.157 0.125 0.999 N 0.503 0.302 0.346768085243 gnomAD-4.0.0 1.26495E-06 None None None None N None 1.36206E-05 0 None 0 0 None 0 0 8.5773E-07 0 0
S/T 6575 Ig-50 2 None 0.0787 None 0.98 N 0.523 0.257 0.276898752692 gnomAD-4.0.0 1.39967E-06 None None None None N None 0 0 None 0 0 None 0 0 1.82169E-06 0 0
R/G 6855 Ig-53 2 None 0.2355 None 0.012 N 0.225 0.317 0.475430695062 gnomAD-4.0.0 6.99796E-07 None None None None N None 0 0 None 0 0 None 0 0 9.13641E-07 0 0
R/I 6855 Ig-53 2 rs1231976753 0.1628 0.562 0.029 N 0.337 0.268 0.561751252162 gnomAD-2.1.1 8.97E-06 None None None None N None 0 0 None 2.56871E-04 0 None 0 None 0 0 0
R/I 6855 Ig-53 2 rs1231976753 0.1628 0.562 0.029 N 0.337 0.268 0.561751252162 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 2.88184E-04 0 None 0 0 0 0 0
R/I 6855 Ig-53 2 rs1231976753 0.1628 0.562 0.029 N 0.337 0.268 0.561751252162 gnomAD-4.0.0 3.16376E-06 None None None None N None 0 0 None 1.44352E-04 0 None 0 0 8.60415E-07 0 0
R/S 6855 Ig-53 2 rs2079210485 0.3139 None 0.001 N 0.193 0.115 0.321108458156 gnomAD-4.0.0 1.39989E-06 None None None None N None 0 0 None 0 5.08673E-05 None 0 0 0 0 0
V/L 6949 Ig-54 2 None 0.1208 None 0.27 N 0.316 0.08 0.152612264143 gnomAD-4.0.0 6.9812E-07 None None None None N None 0 0 None 4.0235E-05 0 None 0 0 0 0 0
S/T 7045 Ig-55 2 rs921127943 0.0819 None 0.891 N 0.277 0.14 0.202086224978 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/T 7045 Ig-55 2 rs921127943 0.0819 None 0.891 N 0.277 0.14 0.202086224978 gnomAD-4.0.0 5.13799E-06 None None None None N None 0 0 None 0 0 None 0 0 9.60343E-06 0 0
S/A 7138 Ig-56 2 rs2078830864 0.0905 None 0.953 N 0.337 0.213 0.376039117802 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/A 7138 Ig-56 2 rs2078830864 0.0905 None 0.953 N 0.337 0.213 0.376039117802 gnomAD-4.0.0 6.57289E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47042E-05 0 0
A/E 7231 Ig-57 2 None 0.1542 None 0.012 N 0.398 0.162 0.132336055621 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/T 7231 Ig-57 2 rs1486491329 0.0618 -0.343 None N 0.169 0.064 0.0297737177859 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 3.32E-05 None 0 0 0
A/T 7231 Ig-57 2 rs1486491329 0.0618 -0.343 None N 0.169 0.064 0.0297737177859 gnomAD-4.0.0 2.74132E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.6581E-05 0
Y/C 7324 Ig-58 2 None 0.1942 None 0.999 N 0.425 0.336 0.54038131941 gnomAD-4.0.0 6.85872E-07 None None None None N None 0 0 None 0 0 None 0 0 9.0087E-07 0 0
Y/D 7324 Ig-58 2 rs765632650 0.461 0.335 0.984 N 0.411 0.323 0.677748964116 gnomAD-2.1.1 1.45E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.17E-05 0
Y/D 7324 Ig-58 2 rs765632650 0.461 0.335 0.984 N 0.411 0.323 0.677748964116 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
Y/D 7324 Ig-58 2 rs765632650 0.461 0.335 0.984 N 0.411 0.323 0.677748964116 gnomAD-4.0.0 2.11223E-05 None None None None N None 0 0 None 0 0 None 0 0 2.80169E-05 0 1.60658E-05
F/S 7516 Ig-60 2 rs2078474988 0.1923 None 0.148 N 0.229 0.256 0.531922418639 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
F/S 7516 Ig-60 2 rs2078474988 0.1923 None 0.148 N 0.229 0.256 0.531922418639 gnomAD-4.0.0 6.57194E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47029E-05 0 0
K/N 7609 Ig-61 2 None 0.5461 None 0.997 D 0.454 0.301 0.408036853922 gnomAD-4.0.0 6.93103E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.18601E-05 0
K/R 7609 Ig-61 2 None 0.0727 None 0.98 N 0.422 0.196 0.568250393081 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
V/I 7703 Ig-62 2 rs1318077959 0.0689 -0.088 None N 0.199 0.106 0.180583059064 gnomAD-2.1.1 4.56E-06 None None None None N None 0 0 None 0 6.18E-05 None 0 None 0 0 0
V/I 7703 Ig-62 2 rs1318077959 0.0689 -0.088 None N 0.199 0.106 0.180583059064 gnomAD-4.0.0 3.34496E-06 None None None None N None 0 0 None 0 5.59441E-05 None 0 0 0 0 0
R/Q 7796 Ig-63 2 rs267599059 0.1115 0.095 0.956 N 0.267 0.233 None gnomAD-2.1.1 7.59E-05 None None None None N None 7.45342E-04 5.72E-05 None 0 0 None 0 None 0 7.91E-06 0
R/Q 7796 Ig-63 2 rs267599059 0.1115 0.095 0.956 N 0.267 0.233 None gnomAD-3.1.2 2.03813E-04 None None None None N None 6.51607E-04 6.55E-05 0 0 0 None 0 0 1.47E-05 0 9.57854E-04
R/Q 7796 Ig-63 2 rs267599059 0.1115 0.095 0.956 N 0.267 0.233 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
R/Q 7796 Ig-63 2 rs267599059 0.1115 0.095 0.956 N 0.267 0.233 None gnomAD-4.0.0 3.856E-05 None None None None N None 5.47923E-04 5.0388E-05 None 0 0 None 0 0 9.35303E-06 1.10818E-05 9.64351E-05
R/G 7890 Ig-64 2 rs1356279706 0.1444 -0.341 0.024 N 0.281 0.265 0.40032279838 gnomAD-2.1.1 4.14E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.15E-06 0
R/I 7890 Ig-64 2 rs370939248 0.1262 0.5 0.029 N 0.385 0.332 None gnomAD-2.1.1 1.24E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.75E-05 0
R/I 7890 Ig-64 2 rs370939248 0.1262 0.5 0.029 N 0.385 0.332 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/I 7890 Ig-64 2 rs370939248 0.1262 0.5 0.029 N 0.385 0.332 None gnomAD-4.0.0 1.55928E-05 None None None None N None 1.34485E-05 1.70097E-05 None 0 0 None 0 0 1.78882E-05 0 3.22924E-05
S/F 7986 Ig-65 2 rs528627735 0.1225 -0.915 0.999 N 0.673 0.384 0.707210613629 gnomAD-2.1.1 8.45E-05 None None None None N None 0 0 None 0 0 None 6.55093E-04 None 4.66E-05 0 0
S/F 7986 Ig-65 2 rs528627735 0.1225 -0.915 0.999 N 0.673 0.384 0.707210613629 gnomAD-3.1.2 1.32E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 2.07297E-04 0
S/F 7986 Ig-65 2 rs528627735 0.1225 -0.915 0.999 N 0.673 0.384 0.707210613629 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
S/F 7986 Ig-65 2 rs528627735 0.1225 -0.915 0.999 N 0.673 0.384 0.707210613629 gnomAD-4.0.0 3.84437E-05 None None None None N None 1.33444E-05 0 None 0 0 None 1.56318E-05 0 2.54446E-06 6.04236E-04 3.20277E-05
S/F 8079 Ig-66 2 None 0.1508 None 1.0 N 0.837 0.44 0.713362601676 gnomAD-4.0.0 2.06633E-06 None None None None N None 0 0 None 0 0 None 0 0 2.71006E-06 0 0
T/S 8172 Ig-67 2 None 0.0977 None 0.001 N 0.119 0.071 0.136095386433 gnomAD-4.0.0 2.74036E-06 None None None None N None 0 0 None 0 0 None 0 0 3.60183E-06 0 0
Y/N 8265 Ig-68 2 None 0.3341 None 0.997 N 0.552 0.306 0.554721145582 gnomAD-4.0.0 1.6283E-06 None None None None N None 0 0 None 0 0 None 0 0 2.89039E-06 0 0
F/L 8361 Ig-69 2 rs1553901979 0.3226 None None N 0.134 0.073 0.186928172975 gnomAD-4.0.0 6.87138E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01988E-07 0 0
R/G 8550 Ig-71 2 rs371161599 0.423 -0.088 0.954 N 0.387 0.513 None gnomAD-2.1.1 1.55E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.68E-05 0
R/G 8550 Ig-71 2 rs371161599 0.423 -0.088 0.954 N 0.387 0.513 None gnomAD-4.0.0 5.61101E-06 None None None None N None 0 0 None 0 0 None 0 0 7.32605E-06 0 0
R/M 8550 Ig-71 2 None 0.3867 None 0.989 N 0.385 0.367 0.542053899377 gnomAD-4.0.0 7.01471E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.22178E-05 0
R/S 8550 Ig-71 2 rs2077385819 0.5712 None 0.911 N 0.371 0.367 0.299086750705 gnomAD-4.0.0 8.40998E-06 None None None None N None 0 5.15889E-05 None 0 0 None 0 0 9.0601E-06 0 0
I/T 8644 Ig-72 2 rs779643078 0.0941 -1.371 None N 0.202 0.077 0.299427821978 gnomAD-2.1.1 4.18E-06 None None None None N None 0 0 None 0 0 None 3.56E-05 None 0 0 0
I/T 8644 Ig-72 2 rs779643078 0.0941 -1.371 None N 0.202 0.077 0.299427821978 gnomAD-4.0.0 1.62272E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4821E-05 0
I/V 8644 Ig-72 2 rs2077304950 0.0549 None None N 0.067 0.172 0.0806252709748 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
R/K 8737 Ig-73 2 rs769711887 0.0802 -0.113 None N 0.092 0.159 0.225902525712 gnomAD-2.1.1 4.19E-06 None None None None N None 0 0 None 0 5.7E-05 None 0 None 0 0 0
R/K 8737 Ig-73 2 rs769711887 0.0802 -0.113 None N 0.092 0.159 0.225902525712 gnomAD-4.0.0 6.9355E-07 None None None None N None 0 0 None 0 0 None 0 0 9.08698E-07 0 0
T/A 8831 Ig-74 2 None 0.0594 None None N 0.085 0.072 0.0716867268079 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/F 9020 Ig-76 2 rs1211690126 0.1394 -0.655 0.988 N 0.576 0.369 0.692115123808 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
S/F 9020 Ig-76 2 rs1211690126 0.1394 -0.655 0.988 N 0.576 0.369 0.692115123808 gnomAD-4.0.0 6.84952E-07 None None None None N None 0 0 None 0 0 None 0 0 9.0021E-07 0 0
S/T 9020 Ig-76 2 None 0.0844 None 0.134 N 0.239 0.09 0.18995819373 gnomAD-4.0.0 2.05486E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80048E-06 1.16139E-05 0
S/Y 9020 Ig-76 2 None 0.1482 None 0.996 N 0.573 0.4 0.677148692323 gnomAD-4.0.0 6.84952E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16139E-05 0
K/I 9113 Ig-77 2 rs775352248 0.1493 0.378 None N 0.259 0.23 0.510758216515 gnomAD-2.1.1 8.11E-06 None None None None N None 0 0 None 0 1.12423E-04 None 0 None 0 0 0
Y/C 9206 Ig-78 2 None 0.1894 None 1.0 N 0.603 0.505 0.521970134296 gnomAD-4.0.0 1.36922E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99967E-07 0 1.65755E-05
S/P 9302 Ig-79 2 None 0.8744 None 0.983 N 0.499 0.449 0.343334270461 gnomAD-4.0.0 6.87657E-07 None None None None N None 0 0 None 0 0 None 0 0 9.02975E-07 0 0
S/T 9302 Ig-79 2 rs1160492654 0.0829 0.151 0.034 N 0.225 0.084 0.141422826196 gnomAD-2.1.1 8.17E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.8E-05 0
S/T 9302 Ig-79 2 rs1160492654 0.0829 0.151 0.034 N 0.225 0.084 0.141422826196 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/T 9302 Ig-79 2 rs1160492654 0.0829 0.151 0.034 N 0.225 0.084 0.141422826196 gnomAD-4.0.0 1.86752E-06 None None None None N None 1.34102E-05 0 None 0 0 None 0 0 1.70142E-06 0 0
F/C 9398 Ig-80 2 None 0.2555 None 0.998 None 0.261 0.331 0.747271886432 gnomAD-4.0.0 6.84471E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.657E-05
F/I 9398 Ig-80 2 rs1299415103 0.1087 None 0.064 None 0.115 0.21 0.344710718752 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
F/I 9398 Ig-80 2 rs1299415103 0.1087 None 0.064 None 0.115 0.21 0.344710718752 gnomAD-4.0.0 2.56384E-06 None None None None N None 0 0 None 0 0 None 0 0 4.79177E-06 0 0
F/Y 9398 Ig-80 2 None 0.1295 None 0.969 None 0.287 0.17 0.460616323599 gnomAD-4.0.0 6.84471E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99868E-07 0 0
S/C 9494 Ig-81 2 rs1553886767 0.1358 None 0.978 None 0.512 0.446 0.437207349437 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/N 9494 Ig-81 2 None 0.1554 None 0.002 None 0.23 0.136 0.193865811164 gnomAD-4.0.0 1.59582E-06 None None None None N None 0 0 None 0 2.77454E-05 None 0 0 0 0 0
V/I 9591 Ig-82 2 None 0.0805 None 0.98 None 0.405 0.179 0.615206833243 gnomAD-4.0.0 1.64259E-06 None None None None N None 0 0 None 0 0 None 0 0 2.96873E-06 0 0
T/A 9901 Ig-84 2 None 0.4655 None 0.999 None 0.585 0.285 0.328486982098 gnomAD-4.0.0 1.37252E-06 None None None None I None 0 0 None 0 0 None 0 0 1.80052E-06 0 0
T/I 9901 Ig-84 2 None 0.6448 None 1.0 None 0.778 0.488 0.476205827853 gnomAD-4.0.0 1.60235E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43935E-05 0
T/P 9901 Ig-84 2 rs1295313284 0.9585 -0.363 1.0 None 0.768 0.471 0.415820034956 gnomAD-2.1.1 1.22E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.68E-05 0
T/P 9901 Ig-84 2 rs1295313284 0.9585 -0.363 1.0 None 0.768 0.471 0.415820034956 gnomAD-4.0.0 1.64703E-05 None None None None I None 0 0 None 0 0 None 0 0 2.07059E-05 1.16355E-05 0
A/V 9990 Ig-85 2 rs1447594243 0.145 0.81 0.001 None 0.149 0.086 0.144782658237 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
A/V 9990 Ig-85 2 rs1447594243 0.145 0.81 0.001 None 0.149 0.086 0.144782658237 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/V 9990 Ig-85 2 rs1447594243 0.145 0.81 0.001 None 0.149 0.086 0.144782658237 gnomAD-4.0.0 6.56909E-06 None None None None N None 2.41208E-05 0 None 0 0 None 0 0 0 0 0
Q/R 10079 Ig-86 2 rs752672136 0.2241 0.344 0.92 None 0.293 0.287 0.238096912614 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
Q/R 10079 Ig-86 2 rs752672136 0.2241 0.344 0.92 None 0.293 0.287 0.238096912614 gnomAD-4.0.0 1.59282E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86257E-06 0 0
R/C 13781 Ig-88 2 rs768469221 0.2716 -1.791 0.996 N 0.705 0.325 0.406668915854 gnomAD-2.1.1 2.43E-05 None None None None N None 0 0 None 0 0 None 1.77321E-04 None 0 1.07E-05 0
R/C 13781 Ig-88 2 rs768469221 0.2716 -1.791 0.996 N 0.705 0.325 0.406668915854 gnomAD-4.0.0 1.4801E-05 None None None None N None 0 0 None 0 0 None 0 0 9.18341E-06 1.38487E-04 0
R/H 13781 Ig-88 2 rs370878642 0.142 -2.204 0.022 N 0.345 0.103 None gnomAD-2.1.1 1.44E-05 None None None None N None 7.23E-05 0 None 0 0 None 0 None 0 2.12E-05 0
R/H 13781 Ig-88 2 rs370878642 0.142 -2.204 0.022 N 0.345 0.103 None gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/H 13781 Ig-88 2 rs370878642 0.142 -2.204 0.022 N 0.345 0.103 None gnomAD-4.0.0 5.14997E-05 None None None None N None 1.35744E-05 0 None 0 0 None 0 0 6.65026E-05 3.54669E-05 0
R/S 13781 Ig-88 2 rs768469221 0.7204 -1.785 0.228 N 0.556 0.208 0.168933306366 gnomAD-2.1.1 4.86E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.07E-05 0
R/S 13781 Ig-88 2 rs768469221 0.7204 -1.785 0.228 N 0.556 0.208 0.168933306366 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/S 13781 Ig-88 2 rs768469221 0.7204 -1.785 0.228 N 0.556 0.208 0.168933306366 gnomAD-4.0.0 4.45638E-06 None None None None N None 0 0 None 0 0 None 0 0 6.05065E-06 0 0
E/Q 13966 Ig-90 2 None 0.1649 None 0.001 N 0.279 0.095 0.168933306366 gnomAD-4.0.0 1.59281E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86049E-06 0 0
D/A 14055 Ig-91 2 None 0.5689 None 0.996 N 0.667 0.321 0.589843679045 gnomAD-4.0.0 1.593E-06 None None None None N None 0 0 None 0 2.77531E-05 None 0 0 0 0 0
D/E 14055 Ig-91 2 None 0.6033 None 0.999 N 0.561 0.222 0.27132560031 gnomAD-4.0.0 6.84496E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99693E-07 0 0
Y/C 14232 Ig-93 2 rs1200157031 0.1961 -0.064 0.151 D 0.424 0.287 0.42748209135 gnomAD-2.1.1 8.12E-06 None None None None N None 0 2.91E-05 None 0 0 None 3.27E-05 None 0 0 0
Y/C 14232 Ig-93 2 rs1200157031 0.1961 -0.064 0.151 D 0.424 0.287 0.42748209135 gnomAD-4.0.0 3.18758E-06 None None None None N None 0 4.5798E-05 None 0 0 None 0 0 0 0 0
K/E 14320 Ig-94 2 rs6723526 0.3171 None 0.997 N 0.657 0.255 None gnomAD-2.1.1 8.16223E-02 None None None None N None 1.69618E-02 4.19982E-02 None 6.9049E-02 6.07246E-03 None 1.02397E-01 None 1.00744E-01 1.07933E-01 9.38557E-02
K/E 14320 Ig-94 2 rs6723526 0.3171 None 0.997 N 0.657 0.255 None gnomAD-3.1.2 7.22893E-02 None None None None N None 1.79123E-02 5.89855E-02 5.8114E-02 6.62824E-02 6.20636E-03 None 1.02545E-01 7.27848E-02 1.0715E-01 9.89627E-02 7.74379E-02
K/E 14320 Ig-94 2 rs6723526 0.3171 None 0.997 N 0.657 0.255 None 1000 genomes 5.09185E-02 None None None None N None 6.1E-03 6.2E-02 None None 5E-03 1.004E-01 None None None 1.002E-01 None
K/E 14320 Ig-94 2 rs6723526 0.3171 None 0.997 N 0.657 0.255 None gnomAD-4.0.0 9.75801E-02 None None None None N None 1.63081E-02 4.77868E-02 None 6.80235E-02 1.01362E-02 None 1.00128E-01 9.39153E-02 1.09024E-01 1.05563E-01 9.01752E-02
K/T 14320 Ig-94 2 None 0.257 None 0.999 N 0.729 0.527 0.461408135625 gnomAD-4.0.0 1.5934E-06 None None None None N None 0 0 None 4.77099E-05 0 None 0 0 0 0 0
I/M 14409 Ig-95 2 rs1427373218 0.178 -0.432 0.996 D 0.406 0.435 0.752625438931 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.82E-05 None 0 0 0
I/M 14409 Ig-95 2 rs1427373218 0.178 -0.432 0.996 D 0.406 0.435 0.752625438931 gnomAD-4.0.0 2.7383E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.63962E-05 0
Y/H 14587 Ig-97 2 rs774085986 0.2806 -0.943 1.0 N 0.705 0.448 0.488616904302 gnomAD-2.1.1 1.84E-05 None None None None N None 4.19E-05 0 None 0 0 None 0 None 0 3.23E-05 0
Y/H 14587 Ig-97 2 rs774085986 0.2806 -0.943 1.0 N 0.705 0.448 0.488616904302 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
Y/H 14587 Ig-97 2 rs774085986 0.2806 -0.943 1.0 N 0.705 0.448 0.488616904302 gnomAD-4.0.0 8.70502E-06 None None None None N None 1.33668E-05 1.67718E-05 None 0 0 None 0 0 1.01853E-05 0 0
E/K 14854 Ig-100 2 None 0.4519 None 0.958 N 0.521 0.345 0.462721901306 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/G 14943 Ig-101 2 None 0.3704 None 0.978 D 0.639 0.55 0.515317749148 gnomAD-4.0.0 1.38022E-06 None None None None N None 3.01386E-05 0 None 0 0 None 0 0 9.04624E-07 0 0
V/A 15032 Ig-102 2 rs1358140088 0.1385 None 0.201 N 0.29 0.102 0.416328079214 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 2.88351E-04 0 None 0 0 0 0 0
V/A 15032 Ig-102 2 rs1358140088 0.1385 None 0.201 N 0.29 0.102 0.416328079214 gnomAD-4.0.0 2.57058E-06 None None None None N None 0 0 None 8.20345E-05 0 None 0 0 0 0 0
V/I 15032 Ig-102 2 rs768820093 0.0786 -0.097 0.004 N 0.154 0.104 0.46017455471 gnomAD-2.1.1 4.1E-06 None None None None N None 0 0 None 0 5.73E-05 None 0 None 0 0 0
E/K 15121 Ig-103 2 rs1264862895 0.4376 0.317 0.998 N 0.51 0.37 0.367992661779 gnomAD-2.1.1 4.07E-06 None None None None N None 0 2.94E-05 None 0 0 None 0 None 0 0 0
E/K 15121 Ig-103 2 rs1264862895 0.4376 0.317 0.998 N 0.51 0.37 0.367992661779 gnomAD-4.0.0 4.79411E-06 None None None None N None 0 6.93033E-05 None 0 0 None 0 0 0 0 0
R/S 15209 Ig-104 2 None 0.5076 None 0.09 N 0.31 0.138 0.151104730317 gnomAD-4.0.0 6.85951E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00367E-07 0 0
R/K 15303 Ig-105 2 None 0.1321 None 0.997 N 0.452 0.286 0.485348376517 gnomAD-4.0.0 1.60534E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87292E-06 0 0
R/M 15303 Ig-105 2 rs771683786 0.382 -0.315 1.0 N 0.694 0.409 0.465209535841 gnomAD-2.1.1 5.46E-05 None None None None N None 0 0 None 0 0 None 0 None 6.05571E-04 0 0
R/M 15303 Ig-105 2 rs771683786 0.382 -0.315 1.0 N 0.694 0.409 0.465209535841 gnomAD-3.1.2 9.87E-05 None None None None N None 0 0 0 0 0 None 1.41376E-03 0 0 0 0
R/M 15303 Ig-105 2 rs771683786 0.382 -0.315 1.0 N 0.694 0.409 0.465209535841 gnomAD-4.0.0 4.90436E-05 None None None None N None 0 0 None 0 0 None 5.97653E-04 0 0 0 0
R/S 15303 Ig-105 2 None 0.6104 None 1.0 N 0.7 0.349 0.379366414296 gnomAD-4.0.0 6.86754E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00891E-07 0 0
R/T 15303 Ig-105 2 rs771683786 0.3377 -0.395 1.0 N 0.697 0.395 0.490839437361 gnomAD-2.1.1 4.11E-06 None None None None N None 0 3E-05 None 0 0 None 0 None 0 0 0
R/T 15303 Ig-105 2 rs771683786 0.3377 -0.395 1.0 N 0.697 0.395 0.490839437361 gnomAD-4.0.0 1.60534E-06 None None None None N None 0 2.34335E-05 None 0 0 None 0 0 0 0 0
E/Q 15481 Ig-107 2 None 0.3025 None 1.0 D 0.591 0.421 0.461323234107 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
K/E 15569 Ig-108 2 rs777791019 0.1474 0.318 0.454 N 0.406 0.186 0.30212335484 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 3.31E-05 None 0 0 0
K/E 15569 Ig-108 2 rs777791019 0.1474 0.318 0.454 N 0.406 0.186 0.30212335484 gnomAD-4.0.0 1.60247E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44346E-05 0
T/A 16956 Ig-111 2 rs1250320003 0.0855 None 0.17 N 0.185 0.121 0.312001716656 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/A 16956 Ig-111 2 rs1250320003 0.0855 None 0.17 N 0.185 0.121 0.312001716656 gnomAD-4.0.0 1.30271E-05 None None None None I None 0 0 None 0 0 None 0 0 1.61135E-05 0 3.2078E-05
T/I 16956 Ig-111 2 rs1040561744 0.1632 0.179 0.1 D 0.251 0.281 0.427254322456 gnomAD-2.1.1 1.22E-05 None None None None I None 0 5.84E-05 None 0 5.66E-05 None 0 None 0 0 0
T/I 16956 Ig-111 2 rs1040561744 0.1632 0.179 0.1 D 0.251 0.281 0.427254322456 gnomAD-4.0.0 2.05468E-06 None None None None I None 0 4.48773E-05 None 0 2.53627E-05 None 0 0 0 0 0
T/K 16956 Ig-111 2 rs1040561744 0.2182 -0.054 0.991 N 0.535 0.451 0.519889284407 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.67336E-04
T/K 16956 Ig-111 2 rs1040561744 0.2182 -0.054 0.991 N 0.535 0.451 0.519889284407 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 3.16456E-03 0 0 0
T/K 16956 Ig-111 2 rs1040561744 0.2182 -0.054 0.991 N 0.535 0.451 0.519889284407 gnomAD-4.0.0 3.10166E-06 None None None None I None 0 0 None 0 0 None 0 3.29598E-04 2.54423E-06 0 0
T/S 16956 Ig-111 2 rs1250320003 0.1065 -0.438 0.885 N 0.383 0.143 0.353548585375 gnomAD-2.1.1 4.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.96E-06 0
T/S 16956 Ig-111 2 rs1250320003 0.1065 -0.438 0.885 N 0.383 0.143 0.353548585375 gnomAD-4.0.0 6.84915E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99928E-07 0 0
L/P 17969 Ig-114 2 rs780364455 0.6139 -0.436 0.998 N 0.601 0.551 0.73779808135 gnomAD-2.1.1 4.34E-06 None None None None I None 0 0 None 0 0 None 3.69E-05 None 0 0 0
L/P 17969 Ig-114 2 rs780364455 0.6139 -0.436 0.998 N 0.601 0.551 0.73779808135 gnomAD-4.0.0 1.64259E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.4993E-05 0
D/N 18689 Ig-116 2 rs763814390 0.0955 0.034 0.117 N 0.327 0.145 0.242825505644 gnomAD-2.1.1 1.34E-05 None None None None N None 0 0 None 0 0 None 0 None 0 0 5.65185E-04
D/N 18689 Ig-116 2 rs763814390 0.0955 0.034 0.117 N 0.327 0.145 0.242825505644 gnomAD-4.0.0 8.31067E-06 None None None None N None 0 0 None 0 0 None 0 9.93049E-04 0 0 3.13716E-05
A/V 19096 Ig-117 2 rs1559650624 0.2633 -0.062 0.998 N 0.636 0.39 0.365509141856 gnomAD-2.1.1 8.07E-06 None None None None N None 0 5.82E-05 None 0 0 None 0 None 0 0 0
A/V 19096 Ig-117 2 rs1559650624 0.2633 -0.062 0.998 N 0.636 0.39 0.365509141856 gnomAD-4.0.0 3.1855E-06 None None None None N None 0 4.5798E-05 None 0 0 None 0 0 0 0 0
N/I 19791 Ig-119 2 rs2050467493 0.5745 None 0.988 N 0.475 0.344 0.558850992237 gnomAD-4.0.0 1.36889E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7993E-06 0 0
D/G 20081 Ig-120 2 rs369680191 0.925 -0.305 1.0 N 0.705 0.579 None gnomAD-2.1.1 2.22E-05 None None None None I None 0 0 None 4.55166E-04 0 None 0 None 0 9.4E-06 0
D/G 20081 Ig-120 2 rs369680191 0.925 -0.305 1.0 N 0.705 0.579 None gnomAD-4.0.0 9.05774E-06 None None None None I None 0 0 None 3.19591E-04 0 None 0 0 2.71807E-06 0 3.37075E-05
D/H 20081 Ig-120 2 rs773444432 0.9623 0.541 1.0 N 0.687 0.516 0.539478914628 gnomAD-2.1.1 4.44E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.42E-06 0
D/H 20081 Ig-120 2 rs773444432 0.9623 0.541 1.0 N 0.687 0.516 0.539478914628 gnomAD-4.0.0 1.66195E-06 None None None None I None 0 0 None 0 0 None 0 0 2.92661E-06 0 0
V/F 20480 Ig-121 2 rs1043320696 0.4058 None 0.976 N 0.574 0.303 0.564466916518 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/F 20480 Ig-121 2 rs1043320696 0.4058 None 0.976 N 0.574 0.303 0.564466916518 gnomAD-4.0.0 1.91008E-06 None None None None N None 2.71673E-05 0 None 0 0 None 0 0 0 0 1.65131E-05
V/I 20480 Ig-121 2 None 0.0966 None 0.704 N 0.537 0.159 0.242825505644 gnomAD-4.0.0 1.40984E-06 None None None None N None 0 0 None 0 0 None 0 0 1.8331E-06 0 0
V/A 20770 Ig-122 2 rs532360660 0.313 -1.04 0.994 N 0.421 0.231 0.484329738948 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/A 20770 Ig-122 2 rs532360660 0.313 -1.04 0.994 N 0.421 0.231 0.484329738948 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
V/A 20770 Ig-122 2 rs532360660 0.313 -1.04 0.994 N 0.421 0.231 0.484329738948 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
V/A 20770 Ig-122 2 rs532360660 0.313 -1.04 0.994 N 0.421 0.231 0.484329738948 gnomAD-4.0.0 6.57237E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07125E-04 0
A/G 21178 Ig-123 2 None 0.2737 None 0.025 N 0.309 0.306 0.550545596621 gnomAD-4.0.0 4.84588E-06 None None None None N None 0 0 None 0 0 None 0 0 5.807E-06 0 3.06185E-05
A/S 21178 Ig-123 2 rs1299782984 0.1473 -0.668 0.805 N 0.43 0.194 0.508637063495 gnomAD-2.1.1 4.16E-06 None None None None N None 0 0 None 0 5.65E-05 None 0 None 0 0 0
V/A 21867 Ig-125 2 None 0.1458 None 0.165 N 0.589 0.238 0.520694202979 gnomAD-4.0.0 3.21161E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.90141E-05 0
V/M 21867 Ig-125 2 rs769884849 0.1401 -0.575 0.457 N 0.677 0.095 0.323615622048 gnomAD-2.1.1 3.29E-05 None None None None N None 0 5.85E-05 None 0 2.82965E-04 None 0 None 0 9.14E-06 0
V/M 21867 Ig-125 2 rs769884849 0.1401 -0.575 0.457 N 0.677 0.095 0.323615622048 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94024E-04 None 0 0 0 0 0
V/M 21867 Ig-125 2 rs769884849 0.1401 -0.575 0.457 N 0.677 0.095 0.323615622048 gnomAD-4.0.0 7.46802E-06 None None None None N None 0 3.3493E-05 None 0 2.02038E-04 None 0 0 8.50596E-07 0 0
D/E 22266 Ig-126 2 rs1380514691 0.1114 0.069 None N 0.255 0.048 0.0762999501168 gnomAD-2.1.1 4.08E-06 None None None None I None 6.51E-05 0 None 0 0 None 0 None 0 0 0
D/E 22266 Ig-126 2 rs1380514691 0.1114 0.069 None N 0.255 0.048 0.0762999501168 gnomAD-4.0.0 6.8535E-07 None None None None I None 2.99814E-05 0 None 0 0 None 0 0 0 0 0
D/N 22266 Ig-126 2 None 0.1842 None 0.22 D 0.447 0.196 0.298745278005 gnomAD-4.0.0 1.59782E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86518E-06 0 0
T/I 22951 Ig-128 2 None 0.1619 None 0.096 N 0.432 0.129 0.26547132957 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/I 23346 Ig-129 2 None 0.2663 None 0.999 N 0.405 0.247 0.409124616982 gnomAD-4.0.0 6.84332E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99593E-07 0 0
I/T 23638 Ig-130 2 rs1709621384 0.675 None 0.989 N 0.479 0.4 0.686637490652 gnomAD-4.0.0 1.59336E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86053E-06 0 0
A/T 24432 Ig-132 2 None 0.1285 None 0.805 N 0.452 0.267 0.258283824007 gnomAD-4.0.0 1.59206E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85966E-06 0 0
A/P 24717 Ig-133 2 rs1243147358 0.8382 0.529 0.99 N 0.445 0.337 0.295974979623 gnomAD-2.1.1 4.04E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
A/P 24717 Ig-133 2 rs1243147358 0.8382 0.529 0.99 N 0.445 0.337 0.295974979623 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
A/P 24717 Ig-133 2 rs1243147358 0.8382 0.529 0.99 N 0.445 0.337 0.295974979623 gnomAD-4.0.0 5.12824E-06 None None None None N None 6.77048E-05 0 None 0 0 None 0 0 0 0 0
S/T 25112 Ig-134 2 rs984744354 0.1019 -0.424 0.024 N 0.365 0.044 0.15556083564 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/T 25112 Ig-134 2 rs984744354 0.1019 -0.424 0.024 N 0.365 0.044 0.15556083564 gnomAD-4.0.0 1.59172E-06 None None None None N None 0 2.28655E-05 None 0 0 None 0 0 0 0 0
E/K 25515 Ig-135 2 rs755797898 0.6943 0.602 0.684 N 0.477 0.251 0.331876078066 gnomAD-2.1.1 8.12E-06 None None None None N None 0 0 None 0 1.13636E-04 None 0 None 0 0 0
D/G 26595 Ig-138 2 None 0.5799 None 1.0 D 0.767 0.585 0.473143432122 gnomAD-4.0.0 1.59168E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85889E-06 0 0
D/H 26595 Ig-138 2 rs56307213 0.8097 0.344 1.0 D 0.777 0.689 None gnomAD-2.1.1 1.48054E-02 None None None None N None 3.51327E-03 1.01244E-02 None 8.60402E-03 1.53909E-04 None 1.09143E-02 None 2.19151E-02 2.04102E-02 1.65637E-02
D/H 26595 Ig-138 2 rs56307213 0.8097 0.344 1.0 D 0.777 0.689 None gnomAD-3.1.2 1.44498E-02 None None None None N None 4.17572E-03 1.45803E-02 3.28947E-03 1.03687E-02 3.87297E-04 None 2.15672E-02 9.49367E-03 2.13267E-02 1.1194E-02 1.19503E-02
D/H 26595 Ig-138 2 rs56307213 0.8097 0.344 1.0 D 0.777 0.689 None 1000 genomes 7.38818E-03 None None None None N None 0 8.6E-03 None None 0 2.49E-02 None None None 6.1E-03 None
D/H 26595 Ig-138 2 rs56307213 0.8097 0.344 1.0 D 0.777 0.689 None gnomAD-4.0.0 1.75566E-02 None None None None N None 3.69274E-03 1.19075E-02 None 9.22422E-03 8.921E-05 None 2.36203E-02 1.1555E-02 1.98895E-02 1.11009E-02 1.60557E-02
L/I 27677 Ig-141 2 rs1704290061 0.3075 None 0.999 N 0.457 0.257 0.439551795455 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/I 27677 Ig-141 2 rs1704290061 0.3075 None 0.999 N 0.457 0.257 0.439551795455 gnomAD-4.0.0 6.57393E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47016E-05 0 0
M/I 28359 Ig-143 2 rs773774387 0.6507 0.112 0.007 N 0.137 0.083 0.313210971179 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
M/I 28359 Ig-143 2 rs773774387 0.6507 0.112 0.007 N 0.137 0.083 0.313210971179 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
M/I 28359 Ig-143 2 rs773774387 0.6507 0.112 0.007 N 0.137 0.083 0.313210971179 gnomAD-4.0.0 1.59109E-06 None None None None I None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
M/R 28359 Ig-143 2 rs763428327 0.8413 1.01 0.213 N 0.304 0.351 0.570965073944 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
M/R 28359 Ig-143 2 rs763428327 0.8413 1.01 0.213 N 0.304 0.351 0.570965073944 gnomAD-4.0.0 6.84172E-07 None None None None I None 0 2.23614E-05 None 0 0 None 0 0 0 0 0
M/T 28359 Ig-143 2 None 0.7122 None 0.351 N 0.27 0.313 0.713738877976 gnomAD-4.0.0 2.05252E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69832E-06 0 0
M/I 29046 Ig-145 2 rs1559264784 0.5736 None 0.985 N 0.401 0.352 0.601307451256 gnomAD-4.0.0 6.87441E-07 None None None None N None 0 0 None 0 0 None 1.87864E-05 0 0 0 0
M/K 29046 Ig-145 2 None 0.6097 None 0.994 N 0.383 0.508 0.7005188687 gnomAD-4.0.0 1.37497E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80129E-06 0 0
M/R 29046 Ig-145 2 rs143975327 0.6187 1.288 0.998 N 0.34 0.551 None gnomAD-2.1.1 2.13861E-04 None None None None N None 2.33723E-03 0 None 0 5.27E-05 None 0 None 0 0 1.43637E-04
M/R 29046 Ig-145 2 rs143975327 0.6187 1.288 0.998 N 0.34 0.551 None gnomAD-3.1.2 6.56814E-04 None None None None N None 2.24259E-03 4.57995E-04 0 0 0 None 0 0 0 0 0
M/R 29046 Ig-145 2 rs143975327 0.6187 1.288 0.998 N 0.34 0.551 None 1000 genomes 5.99042E-04 None None None None N None 2.3E-03 0 None None 0 0 None None None 0 None
M/R 29046 Ig-145 2 rs143975327 0.6187 1.288 0.998 N 0.34 0.551 None gnomAD-4.0.0 1.19481E-04 None None None None N None 2.37425E-03 1.54852E-04 None 0 0 None 0 0 1.69728E-06 0 6.42797E-05
M/T 29046 Ig-145 2 rs143975327 0.3993 0.822 0.994 N 0.4 0.487 0.726377241608 gnomAD-2.1.1 4.17E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.11E-06 0
M/T 29046 Ig-145 2 rs143975327 0.3993 0.822 0.994 N 0.4 0.487 0.726377241608 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/T 29046 Ig-145 2 rs143975327 0.3993 0.822 0.994 N 0.4 0.487 0.726377241608 gnomAD-4.0.0 3.11172E-06 None None None None N None 0 0 None 0 0 None 0 0 4.24316E-06 0 0
E/D 29445 Ig-146 2 rs1391026926 0.2591 -0.317 0.999 N 0.527 0.208 0.418221603839 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
E/D 29445 Ig-146 2 rs1391026926 0.2591 -0.317 0.999 N 0.527 0.208 0.418221603839 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/D 29445 Ig-146 2 rs1391026926 0.2591 -0.317 0.999 N 0.527 0.208 0.418221603839 gnomAD-4.0.0 6.57376E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4699E-05 0 0
E/Q 29445 Ig-146 2 None 0.2303 None 1.0 N 0.591 0.281 0.388495093706 gnomAD-4.0.0 1.59788E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86244E-06 0 0
V/A 29843 Ig-147 2 None 0.3143 None 0.37 N 0.289 0.182 0.397391247328 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/E 29843 Ig-147 2 None 0.6394 None 0.997 N 0.611 0.476 0.782665743468 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/M 29843 Ig-147 2 rs376014865 0.2744 None 0.997 N 0.501 0.207 None gnomAD-4.0.0 1.38498E-06 None None None None N None 0 0 None 0 0 None 0 0 1.81122E-06 0 0
L/V 30133 Ig-148 2 None 0.1053 None 0.898 D 0.547 0.244 0.46435556306 gnomAD-4.0.0 1.59263E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86164E-06 0 0
D/H 30928 Ig-150 2 rs397517756 0.7155 0.773 1.0 N 0.707 0.583 None gnomAD-2.1.1 1.07216E-04 None None None None N None 0 2.83E-05 None 0 0 None 0 None 0 2.26527E-04 0
D/H 30928 Ig-150 2 rs397517756 0.7155 0.773 1.0 N 0.707 0.583 None gnomAD-3.1.2 1.51196E-04 None None None None N None 0 5.89545E-04 0 0 0 None 0 0 2.05834E-04 0 0
D/H 30928 Ig-150 2 rs397517756 0.7155 0.773 1.0 N 0.707 0.583 None gnomAD-4.0.0 1.23979E-04 None None None None N None 0 3.16762E-04 None 0 0 None 0 0 1.43244E-04 0 1.92135E-04
G/R 31219 Ig-151 2 rs2154147060 0.338 None 0.934 N 0.419 0.295 0.572208630285 gnomAD-4.0.0 2.0529E-06 None None None None N None 0 2.23774E-05 None 0 0 None 0 1.73551E-04 8.99539E-07 0 0
D/E 32018 Ig-153 2 rs773714477 0.1254 None 0.046 N 0.352 0.044 0.183819452728 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/E 32018 Ig-153 2 rs773714477 0.1254 None 0.046 N 0.352 0.044 0.183819452728 gnomAD-4.0.0 4.96988E-06 None None None None N None 0 0 None 0 0 None 0 0 6.79737E-06 0 0
D/H 32018 Ig-153 2 rs1275646531 0.4107 -0.833 0.998 N 0.743 0.356 0.426551566703 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 6.42674E-04 None 0 None 0 0 0
D/H 32018 Ig-153 2 rs1275646531 0.4107 -0.833 0.998 N 0.743 0.356 0.426551566703 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92604E-04 None 0 0 0 0 0
D/H 32018 Ig-153 2 rs1275646531 0.4107 -0.833 0.998 N 0.743 0.356 0.426551566703 gnomAD-4.0.0 6.57246E-06 None None None None N None 0 0 None 0 1.92604E-04 None 0 0 0 0 0
L/F 32308 Ig-154 2 None 0.1988 None 0.007 N 0.357 0.076 0.435915822735 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/R 32308 Ig-154 2 rs749636019 0.4899 -0.683 0.879 N 0.728 0.477 0.838891562718 gnomAD-2.1.1 4.11E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.07E-06 0
R/G 32709 Ig-155 2 rs1372889503 0.1744 -0.121 0.175 N 0.367 0.176 0.379193981924 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
G/E 33102 Ig-156 2 rs751364205 0.2134 -0.368 0.969 N 0.402 0.25 0.423119698836 gnomAD-2.1.1 4.11E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.13E-06 0
G/E 33102 Ig-156 2 rs751364205 0.2134 -0.368 0.969 N 0.402 0.25 0.423119698836 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/E 33102 Ig-156 2 rs751364205 0.2134 -0.368 0.969 N 0.402 0.25 0.423119698836 gnomAD-4.0.0 5.59203E-06 None None None None N None 0 0 None 0 0 None 0 0 6.7955E-06 0 1.60539E-05
G/R 33102 Ig-156 2 rs548615687 0.2787 -0.438 0.985 N 0.467 0.332 0.554037457546 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
G/R 33102 Ig-156 2 rs548615687 0.2787 -0.438 0.985 N 0.467 0.332 0.554037457546 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/R 33102 Ig-156 2 rs548615687 0.2787 -0.438 0.985 N 0.467 0.332 0.554037457546 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
G/R 33102 Ig-156 2 rs548615687 0.2787 -0.438 0.985 N 0.467 0.332 0.554037457546 gnomAD-4.0.0 2.48548E-06 None None None None N None 1.33747E-05 0 None 0 0 None 0 0 2.5484E-06 0 0
H/Q 33497 Ig-158 2 rs746874226 0.1133 -0.162 0.005 N 0.167 0.137 0.250579442822 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 9.95E-05 0 None 0 None 0 0 0
H/Q 33497 Ig-158 2 rs746874226 0.1133 -0.162 0.005 N 0.167 0.137 0.250579442822 gnomAD-4.0.0 6.84331E-07 None None None None I None 0 0 None 3.82848E-05 0 None 0 0 0 0 0
H/Y 33497 Ig-158 2 rs768361337 0.097 1.307 0.758 N 0.224 0.224 0.293147016451 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 9.82E-05 None 0 0 0
H/Y 33497 Ig-158 2 rs768361337 0.097 1.307 0.758 N 0.224 0.224 0.293147016451 gnomAD-4.0.0 1.27351E-05 None None None None I None 0 0 None 0 0 None 0 0 0 1.14669E-04 0
V/A 34138 Ig-160 2 rs761112704 0.4534 -0.77 0.165 N 0.515 0.142 0.542764462858 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.86E-06 0
V/A 34138 Ig-160 2 rs761112704 0.4534 -0.77 0.165 N 0.515 0.142 0.542764462858 gnomAD-4.0.0 1.3683E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99408E-07 0 1.65634E-05
V/D 34138 Ig-160 2 None 0.8072 None 0.773 N 0.63 0.321 0.755519617258 gnomAD-4.0.0 6.84151E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99408E-07 0 0
E/K 34259 Ig-161 2 rs1301566986 0.5638 None 0.977 N 0.503 0.367 0.366085729538 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 34259 Ig-161 2 rs1301566986 0.5638 None 0.977 N 0.503 0.367 0.366085729538 gnomAD-4.0.0 1.23928E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69509E-06 0 0
E/Q 34259 Ig-161 2 None 0.3508 None 0.997 N 0.627 0.285 0.463328977263 gnomAD-4.0.0 6.84161E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99408E-07 0 0
M/T 34364 Ig-162 2 rs1057273567 0.8163 0.421 0.801 N 0.353 0.472 0.753800451849 gnomAD-2.1.1 7.14E-06 None None None None I None 0 2.83E-05 None 0 0 None 0 None 0 7.82E-06 0
M/T 34364 Ig-162 2 rs1057273567 0.8163 0.421 0.801 N 0.353 0.472 0.753800451849 gnomAD-4.0.0 4.10552E-06 None None None None I None 0 2.23644E-05 None 0 0 None 0 0 2.6986E-06 0 3.3129E-05
R/Q 34943 Ig-163 2 rs780707238 0.2681 -0.166 1.0 N 0.739 0.421 0.338592109245 gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
R/Q 34943 Ig-163 2 rs780707238 0.2681 -0.166 1.0 N 0.739 0.421 0.338592109245 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/Q 34943 Ig-163 2 rs780707238 0.2681 -0.166 1.0 N 0.739 0.421 0.338592109245 gnomAD-4.0.0 5.57671E-06 None None None None N None 2.66937E-05 0 None 0 6.68211E-05 None 0 0 1.6951E-06 2.19568E-05 0
R/K 35130 Ig-164 2 None 0.1898 None 0.005 N 0.139 0.065 0.3349148499 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
V/L 35421 Ig-166 2 None 0.1664 None 0.002 N 0.135 0.09 0.375861065471 gnomAD-4.0.0 1.59093E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
E/A 35608 Ig-167 2 None 0.2249 None 0.997 N 0.705 0.493 0.460703734027 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 35608 Ig-167 2 rs766501757 0.1776 0.232 0.997 N 0.68 0.362 0.408444019923 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.86E-06 0
E/K 35608 Ig-167 2 rs766501757 0.1776 0.232 0.997 N 0.68 0.362 0.408444019923 gnomAD-4.0.0 1.5909E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85752E-06 0 0
A/G 35703 Ig-168 2 rs757500242 0.177 -0.386 0.012 N 0.278 0.058 0.178374595973 gnomAD-2.1.1 1.22E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 1.66722E-04
A/G 35703 Ig-168 2 rs757500242 0.177 -0.386 0.012 N 0.278 0.058 0.178374595973 gnomAD-4.0.0 2.05389E-06 None None None None N None 0 2.24517E-05 None 0 0 None 0 0 1.79959E-06 0 0
A/S 35703 Ig-168 2 None 0.0831 None None N 0.106 0.1 0.115124310173 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/V 35703 Ig-168 2 None 0.1286 None None N 0.18 0.08 0.219573609325 gnomAD-4.0.0 4.10778E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39876E-06 0 0
K/E 35898 Ig-169 2 rs1028436080 0.373 0.38 0.98 N 0.347 0.358 0.391156786388 gnomAD-2.1.1 1.28E-05 None None None 0.239(OBSL1) 0.049(OBSCN) N None 0 9.58E-05 None 0 0 None 0 None 0 0 0
K/E 35898 Ig-169 2 rs1028436080 0.373 0.38 0.98 N 0.347 0.358 0.391156786388 gnomAD-3.1.2 1.97E-05 None None None 0.239(OBSL1) 0.049(OBSCN) N None 0 1.30924E-04 0 0 0 None 0 0 1.47E-05 0 0
K/E 35898 Ig-169 2 rs1028436080 0.373 0.38 0.98 N 0.347 0.358 0.391156786388 gnomAD-4.0.0 7.88915E-06 None None None 0.239(OBSL1) 0.049(OBSCN) N None 0 7.13903E-05 None 0 0 None 0 0 4.90964E-06 0 0
K/I 35898 Ig-169 2 rs774242716 0.6243 0.747 0.999 D 0.65 0.482 0.494500980894 gnomAD-2.1.1 1.89E-05 None None None 0.654(OBSL1) -0.253(OBSCN) N None 0 0 None 0 0 None 0 None 1.63733E-04 8.15E-06 0
K/I 35898 Ig-169 2 rs774242716 0.6243 0.747 0.999 D 0.65 0.482 0.494500980894 gnomAD-3.1.2 1.31E-05 None None None 0.654(OBSL1) -0.253(OBSCN) N None 0 0 0 0 0 None 1.88253E-04 0 0 0 0
K/I 35898 Ig-169 2 rs774242716 0.6243 0.747 0.999 D 0.65 0.482 0.494500980894 gnomAD-4.0.0 2.23475E-05 None None None 0.654(OBSL1) -0.253(OBSCN) N None 0 0 None 0 0 None 1.89358E-04 0 9.81769E-06 0 2.92672E-05

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.