Structural position:

  • Domain Type: Ig
  • Aligned Position: 26
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
T/A 22 Ig-1 17 rs1305775594 0.074 -0.498 None N 0.098 0.122 0.126345400529 gnomAD-2.1.1 3.98E-06 None None None 0.009(TCAP) N None 0 0 None 0 5.45E-05 None 0 None 0 0 0
T/A 22 Ig-1 17 rs1305775594 0.074 -0.498 None N 0.098 0.122 0.126345400529 gnomAD-4.0.0 6.84113E-07 None None None 0.009(TCAP) N None 0 0 None 0 2.51991E-05 None 0 0 0 0 0
T/I 22 Ig-1 17 None 0.1913 None 0.166 D 0.326 0.429 0.411001663086 gnomAD-4.0.0 6.84117E-07 None None None 0.013(TCAP) N None 0 0 None 0 0 None 0 0 0 1.1598E-05 0
S/Y 959 Ig-3 17 None 0.5272 None 1.0 D 0.861 0.505 0.673716824456 gnomAD-4.0.0 1.59062E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8567E-06 0 0
S/R 1098 Ig-4 17 rs745660374 0.5509 None 0.009 N 0.227 0.149 0.0482279557977 gnomAD-2.1.1 3.98E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.81E-06 0
S/R 1098 Ig-4 17 rs745660374 0.5509 None 0.009 N 0.227 0.149 0.0482279557977 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/R 1098 Ig-4 17 rs745660374 0.5509 None 0.009 N 0.227 0.149 0.0482279557977 gnomAD-4.0.0 8.05496E-06 None None None None I None 0 0 None 0 0 None 0 0 1.10169E-05 0 0
G/D 1307 Ig-5 17 rs776940545 0.6145 -0.99 0.946 N 0.769 0.289 0.112648838833 gnomAD-2.1.1 8E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
G/D 1307 Ig-5 17 rs776940545 0.6145 -0.99 0.946 N 0.769 0.289 0.112648838833 gnomAD-4.0.0 4.10529E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59777E-06 0 3.31203E-05
G/V 1307 Ig-5 17 None 0.413 None 0.946 N 0.782 0.343 0.45746916685 gnomAD-4.0.0 6.84215E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65601E-05
T/S 1473 Ig-6 17 None 0.5463 None 0.999 N 0.534 0.211 0.180583059064 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
R/L 1572 Ig-7 17 rs12476289 0.1449 0.032 0.001 N 0.146 0.215 0.280987212366 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
R/L 1572 Ig-7 17 rs12476289 0.1449 0.032 0.001 N 0.146 0.215 0.280987212366 gnomAD-4.0.0 6.84101E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99315E-07 0 0
R/P 1572 Ig-7 17 None 0.3101 None 0.001 N 0.145 0.259 0.166414681773 gnomAD-4.0.0 2.0523E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69794E-06 0 0
R/Q 1572 Ig-7 17 rs12476289 0.0878 -0.084 0.753 N 0.332 0.064 None gnomAD-2.1.1 7.52661E-02 None None None None N None 1.14583E-02 2.38153E-01 None 4.86674E-02 1.99176E-01 None 1.84568E-02 None 5.32415E-02 4.42459E-02 6.3939E-02
R/Q 1572 Ig-7 17 rs12476289 0.0878 -0.084 0.753 N 0.332 0.064 None gnomAD-3.1.2 4.97469E-02 None None None None N None 1.15886E-02 1.3777E-01 4.82456E-02 4.89914E-02 1.83218E-01 None 5.12917E-02 1.58228E-02 4.5127E-02 2.17842E-02 4.58891E-02
R/Q 1572 Ig-7 17 rs12476289 0.0878 -0.084 0.753 N 0.332 0.064 None 1000 genomes 7.52796E-02 None None None None N None 2.3E-03 1.715E-01 None None 1.895E-01 4.87E-02 None None None 1.53E-02 None
R/Q 1572 Ig-7 17 rs12476289 0.0878 -0.084 0.753 N 0.332 0.064 None gnomAD-4.0.0 5.23823E-02 None None None None N None 1.05977E-02 2.04774E-01 None 4.75644E-02 1.87341E-01 None 5.40245E-02 1.63312E-02 4.49706E-02 1.97329E-02 5.10687E-02
P/L 1719 Ig-8 17 None 0.205 None 1.0 N 0.812 0.532 0.796399135963 gnomAD-4.0.0 1.59067E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85651E-06 0 0
P/S 1719 Ig-8 17 rs1381415747 0.2192 -0.659 1.0 N 0.791 0.446 0.340273420219 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.84E-06 0
P/S 1719 Ig-8 17 rs1381415747 0.2192 -0.659 1.0 N 0.791 0.446 0.340273420219 gnomAD-4.0.0 1.3682E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79859E-06 0 0
T/N 1857 Ig-9 17 None 0.2723 None 0.995 N 0.448 0.276 0.395745362164 gnomAD-4.0.0 1.59067E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85659E-06 0 0
D/E 2094 Ig-10 17 None 0.3378 None 0.02 N 0.21 0.181 0.283761946502 gnomAD-4.0.0 1.59066E-06 None None None None N None 0 0 None 0 0 None 0 2.4108E-04 0 0 0
D/H 2094 Ig-10 17 None 0.755 None 0.998 D 0.597 0.552 0.454426139905 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
T/A 2190 Ig-11 17 rs1204873968 0.1068 -0.743 0.271 N 0.433 0.184 0.223146558224 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
T/A 2190 Ig-11 17 rs1204873968 0.1068 -0.743 0.271 N 0.433 0.184 0.223146558224 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/A 2190 Ig-11 17 rs1204873968 0.1068 -0.743 0.271 N 0.433 0.184 0.223146558224 gnomAD-4.0.0 2.47841E-06 None None None None N None 0 0 None 0 0 None 0 0 3.38989E-06 0 0
T/I 2190 Ig-11 17 rs767577772 0.317 -0.179 0.928 D 0.721 0.417 0.520803792171 gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.65E-05 0
T/I 2190 Ig-11 17 rs767577772 0.317 -0.179 0.928 D 0.721 0.417 0.520803792171 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 2190 Ig-11 17 rs767577772 0.317 -0.179 0.928 D 0.721 0.417 0.520803792171 gnomAD-4.0.0 3.84227E-06 None None None None N None 0 0 None 0 0 None 0 0 7.17573E-06 0 0
S/A 2283 Ig-12 17 None 0.0883 None 0.022 N 0.11 0.089 0.0806252709748 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
S/T 2283 Ig-12 17 rs764606170 0.0885 -0.341 0.051 N 0.233 0.081 0.0666544352282 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.82E-06 0
I/T 2372 Ig-13 17 None 0.4431 None 1.0 N 0.669 0.51 0.699307346123 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
I/V 2372 Ig-13 17 rs117777236 0.1722 None 0.993 N 0.337 0.302 None gnomAD-4.0.0 1.59064E-06 None None None None N None 0 0 None 0 2.773E-05 None 0 0 0 0 0
N/H 2549 Ig-15 17 rs1277824720 0.2636 None 1.0 N 0.721 0.413 0.165133752707 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
N/H 2549 Ig-15 17 rs1277824720 0.2636 None 1.0 N 0.721 0.413 0.165133752707 gnomAD-4.0.0 1.31425E-05 None None None None N None 0 0 None 0 0 None 0 0 2.93962E-05 0 0
E/V 2636 Ig-16 16 rs1207371966 0.1615 0.189 0.01 N 0.228 0.335 0.417208245017 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.81E-06 0
E/V 2636 Ig-16 16 rs1207371966 0.1615 0.189 0.01 N 0.228 0.335 0.417208245017 gnomAD-4.0.0 3.18187E-06 None None None None N None 0 0 None 0 0 None 0 0 5.715E-06 0 0
D/E 2723 Ig-17 17 None 0.2541 None 0.002 N 0.107 0.045 0.17948927462 gnomAD-4.0.0 1.59077E-06 None None None None N None 0 0 None 4.76599E-05 0 None 0 0 0 0 0
D/G 2723 Ig-17 17 None 0.4457 None 0.379 D 0.346 0.313 0.292423486923 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 2723 Ig-17 17 rs766896377 0.1905 -0.617 0.004 N 0.203 0.11 None gnomAD-2.1.1 7.97E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.76E-05 0
D/N 2723 Ig-17 17 rs766896377 0.1905 -0.617 0.004 N 0.203 0.11 None gnomAD-4.0.0 2.80492E-05 None None None None N None 0 0 None 0 0 None 0 0 3.59719E-05 1.15937E-05 0
T/A 2811 Ig-18 17 rs1574566372 0.0779 None 0.64 N 0.451 0.176 0.12205267543 gnomAD-4.0.0 1.59047E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85647E-06 0 0
T/A 2898 Ig-19 17 None 0.0969 None None N 0.083 0.044 0.119812018005 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/S 2985 Ig-20 17 rs727503684 0.2604 -0.615 0.999 N 0.553 0.252 0.112648838833 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.81E-06 0
T/S 2985 Ig-20 17 rs727503684 0.2604 -0.615 0.999 N 0.553 0.252 0.112648838833 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
T/S 2985 Ig-20 17 rs727503684 0.2604 -0.615 0.999 N 0.553 0.252 0.112648838833 gnomAD-4.0.0 2.03003E-06 None None None None N None 0 6.15536E-05 None 0 0 None 0 0 1.20493E-06 0 0
R/P 3074 Ig-21 17 None 0.8405 None 0.998 N 0.474 0.492 0.533179623451 gnomAD-4.0.0 6.84093E-07 None None None None N None 0 0 None 0 2.52232E-05 None 0 0 0 0 0
R/Q 3074 Ig-21 17 rs565052824 0.3235 0.417 0.985 N 0.509 0.332 0.255270683199 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 5.46E-05 None 0 None 0 0 0
R/Q 3074 Ig-21 17 rs565052824 0.3235 0.417 0.985 N 0.509 0.332 0.255270683199 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 3.84615E-04 None 0 0 0 2.07297E-04 0
R/Q 3074 Ig-21 17 rs565052824 0.3235 0.417 0.985 N 0.509 0.332 0.255270683199 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 1E-03 0 None None None 1E-03 None
R/Q 3074 Ig-21 17 rs565052824 0.3235 0.417 0.985 N 0.509 0.332 0.255270683199 gnomAD-4.0.0 6.19551E-06 None None None None N None 0 0 None 0 8.9218E-05 None 0 0 2.54238E-06 3.29388E-05 0
R/C 3163 Ig-22 17 rs140664731 0.4216 -0.192 1.0 N 0.788 0.559 None gnomAD-2.1.1 1.31282E-04 None None None None N None 1.08147E-03 2.83E-05 None 0 4.02293E-04 None 0 None 0 7.79E-06 0
R/C 3163 Ig-22 17 rs140664731 0.4216 -0.192 1.0 N 0.788 0.559 None gnomAD-3.1.2 2.82668E-04 None None None None N None 8.9303E-04 1.96412E-04 0 0 5.76701E-04 None 0 0 0 0 0
R/C 3163 Ig-22 17 rs140664731 0.4216 -0.192 1.0 N 0.788 0.559 None 1000 genomes 5.99042E-04 None None None None N None 1.5E-03 0 None None 1E-03 0 None None None 0 None
R/C 3163 Ig-22 17 rs140664731 0.4216 -0.192 1.0 N 0.788 0.559 None gnomAD-4.0.0 5.94957E-05 None None None None N None 9.19755E-04 4.9995E-05 None 0 2.45339E-04 None 0 0 4.23845E-06 3.29395E-05 8.00102E-05
R/H 3163 Ig-22 17 rs149755500 0.1709 -0.887 1.0 D 0.767 0.514 None gnomAD-2.1.1 1.9159E-04 None None None None N None 3.20436E-04 0 None 0 0 None 6.54E-05 None 0 3.42695E-04 0
R/H 3163 Ig-22 17 rs149755500 0.1709 -0.887 1.0 D 0.767 0.514 None gnomAD-3.1.2 3.35147E-04 None None None None N None 6.27353E-04 0 0 0 0 None 0 0 3.67528E-04 0 0
R/H 3163 Ig-22 17 rs149755500 0.1709 -0.887 1.0 D 0.767 0.514 None gnomAD-4.0.0 3.39749E-04 None None None None N None 5.20583E-04 0 None 0 2.22975E-05 None 0 0 4.03678E-04 3.29424E-05 4.64416E-04
R/S 3163 Ig-22 17 rs140664731 0.7055 -0.246 1.0 N 0.707 0.329 0.449283877778 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.85E-06 0
P/A 3255 Ig-23 17 rs763012497 0.257 -0.894 0.998 N 0.623 0.42 0.324161360171 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.84E-06 0
P/A 3255 Ig-23 17 rs763012497 0.257 -0.894 0.998 N 0.623 0.42 0.324161360171 gnomAD-4.0.0 2.05242E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69796E-06 0 0
P/R 3255 Ig-23 17 rs2090051409 0.8814 None 1.0 N 0.881 0.499 0.556658385457 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
P/R 3255 Ig-23 17 rs2090051409 0.8814 None 1.0 N 0.881 0.499 0.556658385457 gnomAD-4.0.0 2.56146E-06 None None None None N None 1.6909E-05 0 None 0 2.42354E-05 None 0 0 0 0 0
P/T 3255 Ig-23 17 None 0.5461 -0.892 0.999 N 0.775 0.443 0.453962894745 gnomAD-2.1.1 7.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
P/T 3255 Ig-23 17 None 0.5461 -0.892 0.999 N 0.775 0.443 0.453962894745 gnomAD-4.0.0 2.73657E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69796E-06 1.15942E-05 0
P/L 3361 Ig-24 17 rs879249930 0.1176 -0.361 0.565 N 0.48 0.394 None gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
P/L 3361 Ig-24 17 rs879249930 0.1176 -0.361 0.565 N 0.48 0.394 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92382E-04 None 0 0 0 0 0
P/L 3361 Ig-24 17 rs879249930 0.1176 -0.361 0.565 N 0.48 0.394 None gnomAD-4.0.0 2.56124E-06 None None None None N None 0 1.69457E-05 None 0 2.42436E-05 None 0 0 0 0 0
P/T 3361 Ig-24 17 None 0.098 None 0.565 N 0.376 0.22 0.263140351381 gnomAD-4.0.0 1.59061E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
T/A 3481 Ig-25 17 rs748619545 0.1518 -0.745 None None None 0.046 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.65728E-04
T/A 3481 Ig-25 17 rs748619545 0.1518 -0.745 None None None 0.046 None gnomAD-4.0.0 1.59133E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02407E-05
T/M 3676 Ig-26 17 rs1437975298 0.1072 0.309 None None None 0.078 None gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 1.65837E-04
T/M 3676 Ig-26 17 rs1437975298 0.1072 0.309 None None None 0.078 None gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
T/M 3676 Ig-26 17 rs1437975298 0.1072 0.309 None None None 0.078 None gnomAD-4.0.0 2.5408E-05 None None None None I None 1.33479E-05 0 None 0 0 None 0 0 2.54273E-05 1.09794E-05 1.44097E-04
T/S 3676 Ig-26 17 rs780517993 0.147 -0.572 None None None 0.062 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
V/A 3836 Ig-27 17 None 0.2945 None 0.27 N 0.288 0.089 None gnomAD-4.0.0 1.59149E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8586E-06 0 0
V/M 3836 Ig-27 17 rs397517825 0.2413 -0.158 0.863 N 0.409 0.115 None gnomAD-2.1.1 8.50061E-04 None None None None N None 0 0 None 0 0 None 7.45195E-03 None 0 6.25E-05 2.80741E-04
V/M 3836 Ig-27 17 rs397517825 0.2413 -0.158 0.863 N 0.409 0.115 None gnomAD-3.1.2 2.03711E-04 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 6.21633E-03 0
V/M 3836 Ig-27 17 rs397517825 0.2413 -0.158 0.863 N 0.409 0.115 None 1000 genomes 7.98722E-04 None None None None N None 0 0 None None 0 0 None None None 4.1E-03 None
V/M 3836 Ig-27 17 rs397517825 0.2413 -0.158 0.863 N 0.409 0.115 None gnomAD-4.0.0 4.07748E-04 None None None None N None 0 0 None 0 0 None 0 1.65017E-04 5.93349E-06 6.75275E-03 5.60251E-04
P/L 3954 Ig-28 17 rs1287785786 0.3199 -0.634 0.27 N 0.343 0.216 0.43912465853 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
P/L 3954 Ig-28 17 rs1287785786 0.3199 -0.634 0.27 N 0.343 0.216 0.43912465853 gnomAD-4.0.0 3.42089E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49718E-06 0 0
P/S 3954 Ig-28 17 rs757223770 0.4098 -0.99 0.01 N 0.135 0.098 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
P/S 3954 Ig-28 17 rs757223770 0.4098 -0.99 0.01 N 0.135 0.098 None gnomAD-4.0.0 1.59107E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85789E-06 0 0
I/F 4622 Ig-29 17 rs397517831 0.1076 None 0.033 N 0.289 0.044 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
I/F 4622 Ig-29 17 rs397517831 0.1076 None 0.033 N 0.289 0.044 None gnomAD-4.0.0 6.57047E-06 None None None None N None 0 6.54879E-05 None 0 0 None 0 0 0 0 0
I/T 4622 Ig-29 17 rs750953886 0.0554 -1.552 None N 0.159 0.131 None gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 9.29E-05 0 0
I/T 4622 Ig-29 17 rs750953886 0.0554 -1.552 None N 0.159 0.131 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.42E-05 0 0 0 0
I/T 4622 Ig-29 17 rs750953886 0.0554 -1.552 None N 0.159 0.131 None gnomAD-4.0.0 3.09838E-06 None None None None N None 0 0 None 0 0 None 3.12412E-05 0 2.54272E-06 0 0
L/V 4716 Ig-30 17 None 0.1099 None 0.002 N 0.121 0.175 0.180583059064 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/S 4811 Ig-31 17 rs761096621 0.0945 None None N 0.113 0.145 0.0551355673512 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/S 4811 Ig-31 17 rs761096621 0.0945 None None N 0.113 0.145 0.0551355673512 gnomAD-4.0.0 6.57186E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
A/T 4811 Ig-31 17 rs761096621 0.0766 -0.74 None N 0.136 0.206 0.0611884634855 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 3.3E-05 None 0 0 0
A/T 4811 Ig-31 17 rs761096621 0.0766 -0.74 None N 0.136 0.206 0.0611884634855 gnomAD-4.0.0 2.74008E-06 None None None None I None 2.9924E-05 0 None 0 0 None 0 0 0 3.48667E-05 0
K/E 4904 Ig-32 17 None 0.14 None 0.801 N 0.307 0.176 0.130388298395 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
K/R 4904 Ig-32 17 rs1466517766 0.0797 -0.106 0.012 N 0.178 0.118 0.167679373172 gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.56E-05 1.40607E-04
K/R 4904 Ig-32 17 rs1466517766 0.0797 -0.106 0.012 N 0.178 0.118 0.167679373172 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/R 4904 Ig-32 17 rs1466517766 0.0797 -0.106 0.012 N 0.178 0.118 0.167679373172 gnomAD-4.0.0 3.84316E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78567E-06 0 2.84414E-05
T/A 5184 Ig-35 17 None 0.0674 None 0.022 N 0.111 0.079 0.110078149338 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 5184 Ig-35 17 None 0.126 None 0.966 D 0.412 0.286 0.348764635752 gnomAD-4.0.0 6.84379E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99685E-07 0 0
T/N 5184 Ig-35 17 None 0.0841 None 0.005 N 0.106 0.055 0.202086224978 gnomAD-4.0.0 6.84379E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99685E-07 0 0
P/T 5277 Ig-36 17 None 0.1484 None 0.956 N 0.407 0.251 0.276898752692 gnomAD-4.0.0 1.20036E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31255E-06 0 0
T/N 5373 Ig-37 17 rs1057103177 0.0669 None None N 0.089 0.086 0.200317383148 gnomAD-3.1.2 2.63E-05 None None None None I None 4.83E-05 6.55E-05 0 0 0 None 0 0 0 0 4.78469E-04
T/N 5373 Ig-37 17 rs1057103177 0.0669 None None N 0.089 0.086 0.200317383148 gnomAD-4.0.0 3.72098E-06 None None None None I None 4.00577E-05 1.66978E-05 None 0 0 None 0 0 8.48047E-07 0 1.60246E-05
A/T 5466 Ig-38 17 None 0.0675 None 0.001 N 0.101 0.063 0.0846915920261 gnomAD-4.0.0 1.37218E-06 None None None None I None 0 0 None 0 0 None 0 0 1.80233E-06 0 0
A/D 5560 Ig-39 18 rs1203322735 0.1127 -0.407 0.029 N 0.417 0.08 0.257292322809 gnomAD-2.1.1 8.07E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
A/D 5560 Ig-39 18 rs1203322735 0.1127 -0.407 0.029 N 0.417 0.08 0.257292322809 gnomAD-4.0.0 1.36889E-05 None None None None N None 0 8.94935E-05 None 0 0 None 0 0 1.43952E-05 0 0
D/N 5653 Ig-40 17 rs267599067 0.2789 -0.846 1.0 N 0.565 0.31 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/N 5653 Ig-40 17 rs267599067 0.2789 -0.846 1.0 N 0.565 0.31 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 5653 Ig-40 17 rs267599067 0.2789 -0.846 1.0 N 0.565 0.31 None gnomAD-4.0.0 9.91669E-06 None None None None N None 0 0 None 0 0 None 0 0 9.3247E-06 4.39309E-05 1.60118E-05
T/R 5746 Ig-41 17 rs775732793 0.1399 0.199 0.863 N 0.397 0.176 0.451213972277 gnomAD-2.1.1 2.87E-05 None None None None N None 0 8.52E-05 None 0 0 None 0 None 2.00674E-04 0 0
T/R 5746 Ig-41 17 rs775732793 0.1399 0.199 0.863 N 0.397 0.176 0.451213972277 gnomAD-3.1.2 6.57E-05 None None None None N None 0 0 0 0 0 None 9.41442E-04 0 0 0 0
T/R 5746 Ig-41 17 rs775732793 0.1399 0.199 0.863 N 0.397 0.176 0.451213972277 gnomAD-4.0.0 1.61184E-05 None None None None N None 0 5.00634E-05 None 0 0 None 3.28279E-04 0 1.69564E-06 0 0
P/L 5839 Ig-42 17 None 0.177 None 0.999 N 0.78 0.385 0.536804958393 gnomAD-4.0.0 1.59154E-06 None None None None N None 5.66059E-05 0 None 0 0 None 0 0 0 0 0
P/S 5839 Ig-42 17 None 0.2074 None 0.998 N 0.736 0.298 0.143124449307 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
R/G 6028 Ig-44 17 rs766799309 0.222 -1.092 0.98 N 0.533 0.269 0.388812400583 gnomAD-2.1.1 4.11E-06 None None None None N None 0 2.94E-05 None 0 0 None 0 None 0 0 0
R/G 6028 Ig-44 17 rs766799309 0.222 -1.092 0.98 N 0.533 0.269 0.388812400583 gnomAD-4.0.0 2.05599E-06 None None None None N None 0 2.25073E-05 None 0 0 None 0 0 1.80081E-06 0 0
R/K 6028 Ig-44 17 rs552189742 0.103 -0.396 0.122 N 0.163 0.128 0.130388298395 gnomAD-2.1.1 4.11E-06 None None None None N None 0 0 None 0 5.74E-05 None 0 None 0 0 0
R/K 6028 Ig-44 17 rs552189742 0.103 -0.396 0.122 N 0.163 0.128 0.130388298395 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 3.85654E-04 None 0 0 0 0 0
R/K 6028 Ig-44 17 rs552189742 0.103 -0.396 0.122 N 0.163 0.128 0.130388298395 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 2E-03 0 None None None 0 None
R/K 6028 Ig-44 17 rs552189742 0.103 -0.396 0.122 N 0.163 0.128 0.130388298395 gnomAD-4.0.0 1.31404E-05 None None None None N None 0 0 None 0 3.86548E-04 None 0 0 0 0 0
R/S 6028 Ig-44 17 rs775372762 0.3807 -0.759 0.961 N 0.523 0.279 0.204665344411 gnomAD-2.1.1 4.11E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.12E-06 0
R/T 6028 Ig-44 17 rs552189742 0.1736 None 0.98 N 0.545 0.279 0.369867359543 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
R/T 6028 Ig-44 17 rs552189742 0.1736 None 0.98 N 0.545 0.279 0.369867359543 gnomAD-4.0.0 6.57531E-06 None None None None N None 2.41569E-05 0 None 0 0 None 0 0 0 0 0
S/P 6122 Ig-45 18 rs2080087332 0.1125 None 0.896 N 0.408 0.408 0.351180957027 gnomAD-4.0.0 1.59206E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85904E-06 0 0
D/A 6215 Ig-46 17 rs1267800654 0.1643 -0.397 0.309 N 0.307 0.161 0.254761474806 gnomAD-2.1.1 8.05E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 8.9E-06 0
D/A 6215 Ig-46 17 rs1267800654 0.1643 -0.397 0.309 N 0.307 0.161 0.254761474806 gnomAD-4.0.0 3.18369E-06 None None None None N None 5.66251E-05 0 None 0 0 None 0 0 2.85933E-06 0 0
S/P 6308 Ig-47 17 rs1259623992 0.0955 -0.801 0.523 N 0.401 0.159 0.101711395817 gnomAD-2.1.1 4.17E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.24E-06 0
S/P 6308 Ig-47 17 rs1259623992 0.0955 -0.801 0.523 N 0.401 0.159 0.101711395817 gnomAD-4.0.0 2.05991E-06 None None None None N None 0 0 None 0 0 None 0 0 2.70388E-06 0 0
P/L 6401 Ig-48 17 rs779496338 0.1793 -0.256 0.998 N 0.733 0.327 0.499665682712 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
P/L 6401 Ig-48 17 rs779496338 0.1793 -0.256 0.998 N 0.733 0.327 0.499665682712 gnomAD-4.0.0 1.59847E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4348E-05 0
S/C 6497 Ig-49 17 None 0.1604 None 0.999 N 0.344 0.36 0.400468435593 gnomAD-4.0.0 2.74095E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.49284E-05 1.65926E-05
T/A 6590 Ig-50 17 rs1296238597 0.0708 -0.825 0.005 N 0.099 0.066 0.0806252709748 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.29E-05 None 0 0 0
T/A 6590 Ig-50 17 rs1296238597 0.0708 -0.825 0.005 N 0.099 0.066 0.0806252709748 gnomAD-4.0.0 1.59523E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4403E-05 0
T/I 6590 Ig-50 17 rs760473000 0.1437 -0.126 0.669 N 0.355 0.187 None gnomAD-2.1.1 1.62E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.57E-05 0
T/I 6590 Ig-50 17 rs760473000 0.1437 -0.126 0.669 N 0.355 0.187 None gnomAD-4.0.0 4.79518E-06 None None None None N None 0 0 None 0 0 None 0 0 6.30151E-06 0 0
S/Y 6684 Ig-51 18 None 0.1432 None 0.999 N 0.706 0.376 0.503186968135 gnomAD-4.0.0 1.59571E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86589E-06 0 0
E/Q 6777 Ig-52 17 rs761148465 0.3055 -0.635 0.891 N 0.344 0.218 0.24896430686 gnomAD-2.1.1 3.75E-05 None None None None N None 0 2.47402E-04 None 0 0 None 0 None 0 9.11E-06 0
E/Q 6777 Ig-52 17 rs761148465 0.3055 -0.635 0.891 N 0.344 0.218 0.24896430686 gnomAD-4.0.0 1.46414E-05 None None None None N None 0 1.88226E-04 None 0 0 None 0 0 2.92174E-06 0 0
P/A 6870 Ig-53 17 None 0.0626 None 0.454 N 0.369 0.1 0.130388298395 gnomAD-4.0.0 1.59995E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87249E-06 0 0
T/M 6964 Ig-54 17 rs765257439 0.0903 0.043 0.086 N 0.285 0.11 0.366848117066 gnomAD-2.1.1 6.86E-05 None None None None N None 0 0 None 0 0 None 5.24418E-04 None 0 8.91E-06 0
T/M 6964 Ig-54 17 rs765257439 0.0903 0.043 0.086 N 0.285 0.11 0.366848117066 gnomAD-3.1.2 1.32E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
T/M 6964 Ig-54 17 rs765257439 0.0903 0.043 0.086 N 0.285 0.11 0.366848117066 gnomAD-4.0.0 3.41182E-05 None None None None N None 1.3364E-05 0 None 0 0 None 0 0 7.63575E-06 4.83729E-04 1.60339E-05
S/F 7060 Ig-55 17 rs751613786 0.1985 -0.979 0.061 N 0.239 0.261 0.555277862696 gnomAD-2.1.1 4.04E-06 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 0 0
S/F 7060 Ig-55 17 rs751613786 0.1985 -0.979 0.061 N 0.239 0.261 0.555277862696 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/F 7060 Ig-55 17 rs751613786 0.1985 -0.979 0.061 N 0.239 0.261 0.555277862696 gnomAD-4.0.0 6.57168E-06 None None None None N None 2.41185E-05 0 None 0 0 None 0 0 0 0 0
N/S 7153 Ig-56 17 rs1287422733 0.1039 -0.785 0.023 N 0.113 0.061 0.0846915920261 gnomAD-2.1.1 4.09E-06 None None None None N None 0 2.95E-05 None 0 0 None 0 None 0 0 0
N/S 7153 Ig-56 17 rs1287422733 0.1039 -0.785 0.023 N 0.113 0.061 0.0846915920261 gnomAD-4.0.0 1.60046E-06 None None None None N None 0 2.3083E-05 None 0 0 None 0 0 0 0 0
S/F 7246 Ig-57 17 rs1477073298 0.2852 -0.839 0.989 N 0.427 0.381 0.560757523052 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
S/F 7246 Ig-57 17 rs1477073298 0.2852 -0.839 0.989 N 0.427 0.381 0.560757523052 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
S/F 7246 Ig-57 17 rs1477073298 0.2852 -0.839 0.989 N 0.427 0.381 0.560757523052 gnomAD-4.0.0 3.84442E-06 None None None None N None 5.06637E-05 0 None 0 0 None 0 0 0 0 0
S/L 7339 Ig-58 17 rs72648966 0.0916 -0.284 0.064 N 0.382 0.146 None gnomAD-2.1.1 2.02E-05 None None None None I None 0 0 None 0 5.63E-05 None 0 None 0 2.68E-05 1.67448E-04
S/L 7339 Ig-58 17 rs72648966 0.0916 -0.284 0.064 N 0.382 0.146 None gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
S/L 7339 Ig-58 17 rs72648966 0.0916 -0.284 0.064 N 0.382 0.146 None gnomAD-4.0.0 9.92094E-06 None None None None I None 0 0 None 0 0 None 0 1.64636E-04 1.27187E-05 0 0
P/L 7435 Ig-59 17 rs540312596 0.2403 -0.262 0.502 N 0.412 0.244 0.712169444321 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
P/L 7435 Ig-59 17 rs540312596 0.2403 -0.262 0.502 N 0.412 0.244 0.712169444321 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/L 7435 Ig-59 17 rs540312596 0.2403 -0.262 0.502 N 0.412 0.244 0.712169444321 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
P/S 7435 Ig-59 17 rs375037712 0.1801 -0.912 0.978 N 0.495 0.287 None gnomAD-2.1.1 2.86E-05 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 4.7E-05 0
P/S 7435 Ig-59 17 rs375037712 0.1801 -0.912 0.978 N 0.495 0.287 None gnomAD-3.1.2 3.94E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 4.41E-05 0 0
P/S 7435 Ig-59 17 rs375037712 0.1801 -0.912 0.978 N 0.495 0.287 None gnomAD-4.0.0 3.96699E-05 None None None None N None 5.34259E-05 0 None 0 0 None 1.56226E-05 0 4.74759E-05 0 4.80477E-05
S/C 7531 Ig-60 17 None 0.2742 None 0.999 N 0.375 0.302 0.283371740733 gnomAD-4.0.0 1.59752E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44438E-05 0
S/I 7531 Ig-60 17 None 0.219 None 0.994 N 0.425 0.333 0.33085137897 gnomAD-4.0.0 6.85399E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00559E-07 0 0
S/N 7531 Ig-60 17 rs267599060 0.2084 -0.509 0.746 N 0.365 0.224 None gnomAD-2.1.1 2.16E-05 None None None None N None 2.48221E-04 0 None 0 0 None 0 None 0 0 0
S/N 7531 Ig-60 17 rs267599060 0.2084 -0.509 0.746 N 0.365 0.224 None gnomAD-3.1.2 7.89E-05 None None None None N None 2.89477E-04 0 0 0 0 None 0 0 0 0 0
S/N 7531 Ig-60 17 rs267599060 0.2084 -0.509 0.746 N 0.365 0.224 None gnomAD-4.0.0 1.73786E-05 None None None None N None 3.33975E-04 3.34046E-05 None 0 0 None 0 0 8.48572E-07 0 0
D/G 7718 Ig-62 17 rs1216947854 0.707 -0.905 0.861 N 0.324 0.278 0.154104182512 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
D/G 7718 Ig-62 17 rs1216947854 0.707 -0.905 0.861 N 0.324 0.278 0.154104182512 gnomAD-4.0.0 4.10825E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39864E-06 0 0
D/N 7718 Ig-62 17 None 0.2695 None 0.111 N 0.189 0.146 0.0954503805726 gnomAD-4.0.0 6.84766E-07 None None None None N None 2.99904E-05 0 None 0 0 None 0 0 0 0 0
P/A 7905 Ig-64 17 rs756887462 0.0746 -0.031 None N 0.125 0.076 0.137902524267 gnomAD-2.1.1 8.07E-06 None None None None N None 1.29333E-04 0 None 0 0 None 0 None 0 0 0
P/A 7905 Ig-64 17 rs756887462 0.0746 -0.031 None N 0.125 0.076 0.137902524267 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
P/A 7905 Ig-64 17 rs756887462 0.0746 -0.031 None N 0.125 0.076 0.137902524267 gnomAD-4.0.0 2.56346E-06 None None None None N None 3.38421E-05 0 None 0 0 None 0 0 0 0 0
P/L 7905 Ig-64 17 None 0.1279 None 0.012 N 0.369 0.23 0.405700215632 gnomAD-4.0.0 1.59207E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43328E-05 0
P/S 7905 Ig-64 17 None 0.0984 None 0.002 N 0.177 0.067 0.119812018005 gnomAD-4.0.0 1.59211E-06 None None None None N None 0 0 None 0 2.77346E-05 None 0 0 0 0 0
S/N 8094 Ig-66 17 rs574161330 0.0783 -0.406 0.002 N 0.104 0.131 0.0482279557977 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 5.63E-05 None 0 None 0 0 0
S/N 8094 Ig-66 17 rs574161330 0.0783 -0.406 0.002 N 0.104 0.131 0.0482279557977 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93498E-04 None 0 0 0 0 0
S/N 8094 Ig-66 17 rs574161330 0.0783 -0.406 0.002 N 0.104 0.131 0.0482279557977 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
S/N 8094 Ig-66 17 rs574161330 0.0783 -0.406 0.002 N 0.104 0.131 0.0482279557977 gnomAD-4.0.0 6.5716E-06 None None None None N None 0 0 None 0 1.93949E-04 None 0 0 0 0 0
P/R 8187 Ig-67 17 rs1417467243 0.1804 0.134 0.942 N 0.636 0.31 0.339074221408 gnomAD-2.1.1 8.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
P/R 8187 Ig-67 17 rs1417467243 0.1804 0.134 0.942 N 0.636 0.31 0.339074221408 gnomAD-4.0.0 4.77506E-06 None None None None I None 0 0 None 0 0 None 0 0 8.57716E-06 0 0
P/S 8187 Ig-67 17 None 0.0985 None 0.025 N 0.293 0.093 0.0762999501168 gnomAD-4.0.0 1.59169E-06 None None None None I None 0 0 None 0 2.77408E-05 None 0 0 0 0 0
P/L 8280 Ig-68 17 rs375219172 0.1175 -0.294 0.44 N 0.457 0.335 None gnomAD-2.1.1 8.23E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
P/L 8280 Ig-68 17 rs375219172 0.1175 -0.294 0.44 N 0.457 0.335 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/L 8280 Ig-68 17 rs375219172 0.1175 -0.294 0.44 N 0.457 0.335 None gnomAD-4.0.0 8.09428E-06 None None None None I None 0 0 None 0 0 None 0 0 1.10216E-05 0 0
P/R 8280 Ig-68 17 rs375219172 0.1633 None 0.734 N 0.463 0.384 0.518752145996 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
P/R 8280 Ig-68 17 rs375219172 0.1633 None 0.734 N 0.463 0.384 0.518752145996 gnomAD-4.0.0 1.86791E-06 None None None None I None 0 0 None 0 0 None 0 0 2.54345E-06 0 0
P/S 8376 Ig-69 17 rs375209098 0.1976 -1.367 0.633 N 0.226 0.225 None gnomAD-2.1.1 1.11539E-04 None None None None N None 0 5.68E-05 None 0 0 None 0 None 4.01E-05 2.13398E-04 1.41884E-04
P/S 8376 Ig-69 17 rs375209098 0.1976 -1.367 0.633 N 0.226 0.225 None gnomAD-3.1.2 1.11758E-04 None None None None N None 2.41E-05 0 0 0 0 None 9.43E-05 0 2.20556E-04 0 0
P/S 8376 Ig-69 17 rs375209098 0.1976 -1.367 0.633 N 0.226 0.225 None gnomAD-4.0.0 1.22752E-04 None None None None N None 1.33586E-05 3.33567E-05 None 0 0 None 3.13234E-05 0 1.61081E-04 0 4.80631E-05
S/G 8472 Ig-70 17 rs2077634946 0.1143 None 0.424 N 0.277 0.266 0.110078149338 gnomAD-4.0.0 6.84306E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99599E-07 0 0
S/N 8472 Ig-70 17 None 0.167 None 0.314 N 0.273 0.14 0.0846915920261 gnomAD-4.0.0 6.8431E-07 None None None None N None 2.98936E-05 0 None 0 0 None 0 0 0 0 0
S/R 8472 Ig-70 17 None 0.6723 None 0.022 N 0.287 0.128 0.204665344411 gnomAD-4.0.0 6.84306E-07 None None None None N None 0 0 None 0 2.5194E-05 None 0 0 0 0 0
S/T 8472 Ig-70 17 rs374912661 0.0831 -0.39 0.085 N 0.301 0.092 None gnomAD-2.1.1 4.42E-05 None None None None N None 0 5.8E-05 None 0 0 None 0 None 4.65E-05 7.11E-05 0
S/T 8472 Ig-70 17 rs374912661 0.0831 -0.39 0.085 N 0.301 0.092 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
S/T 8472 Ig-70 17 rs374912661 0.0831 -0.39 0.085 N 0.301 0.092 None gnomAD-4.0.0 2.23117E-05 None None None None N None 0 5.001E-05 None 0 0 None 0 0 2.7975E-05 0 0
D/N 8659 Ig-72 17 rs774443573 0.2049 -0.845 0.992 N 0.685 0.241 0.139678290688 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
D/N 8659 Ig-72 17 rs774443573 0.2049 -0.845 0.992 N 0.685 0.241 0.139678290688 gnomAD-4.0.0 4.77512E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57751E-06 0 0
D/V 8659 Ig-72 17 rs1276014518 0.4891 0.258 0.997 N 0.835 0.389 0.447609009685 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.66E-05 0
D/V 8659 Ig-72 17 rs1276014518 0.4891 0.258 0.997 N 0.835 0.389 0.447609009685 gnomAD-4.0.0 6.36659E-06 None None None None N None 0 0 None 0 0 None 0 0 1.14365E-05 0 0
E/A 8752 Ig-73 17 None 0.0819 None 0.001 N 0.293 0.11 0.0986583533028 gnomAD-4.0.0 1.59258E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85984E-06 0 0
E/K 8752 Ig-73 17 None 0.0932 None 0.003 N 0.317 0.132 0.134241683229 gnomAD-4.0.0 6.84474E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99643E-07 0 0
T/N 8846 Ig-74 17 rs780494547 0.1082 -0.391 0.642 N 0.285 0.163 None gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
T/S 8846 Ig-74 17 None 0.0903 None 0.01 N 0.103 0.044 0.146414634003 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
S/L 8942 Ig-75 17 None 0.1212 None 0.006 N 0.285 0.265 0.430579932962 gnomAD-4.0.0 6.95618E-07 None None None None N None 0 0 None 0 0 None 0 0 9.10152E-07 0 0
N/D 9035 Ig-76 17 None 0.1133 None 0.002 N 0.121 0.098 0.0806252709748 gnomAD-4.0.0 6.8452E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99705E-07 0 0
N/H 9035 Ig-76 17 rs761176331 0.1328 -0.957 0.921 N 0.343 0.218 0.141422826196 gnomAD-2.1.1 3.24E-05 None None None None N None 0 2.0432E-04 None 0 0 None 0 None 0 0 1.6756E-04
N/H 9035 Ig-76 17 rs761176331 0.1328 -0.957 0.921 N 0.343 0.218 0.141422826196 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
N/H 9035 Ig-76 17 rs761176331 0.1328 -0.957 0.921 N 0.343 0.218 0.141422826196 gnomAD-4.0.0 8.67838E-06 None None None None N None 0 1.502E-04 None 0 2.22975E-05 None 0 0 2.54347E-06 0 1.60123E-05
N/S 9035 Ig-76 17 rs1380931214 0.0702 -0.595 0.021 N 0.115 0.079 0.0611884634855 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
N/S 9035 Ig-76 17 rs1380931214 0.0702 -0.595 0.021 N 0.115 0.079 0.0611884634855 gnomAD-4.0.0 1.5931E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86079E-06 0 0
P/L 9128 Ig-77 17 None 0.1157 None 0.521 N 0.382 0.122 0.323886383625 gnomAD-4.0.0 1.36872E-06 None None None None I None 2.98829E-05 0 None 0 0 None 0 0 8.9957E-07 0 0
P/S 9128 Ig-77 17 rs1283675898 0.1034 -0.945 0.028 N 0.218 0.051 0.107399877778 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
P/S 9128 Ig-77 17 rs1283675898 0.1034 -0.945 0.028 N 0.218 0.051 0.107399877778 gnomAD-4.0.0 3.18424E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.86615E-05 0
P/T 9317 Ig-79 17 rs2076618020 0.2125 None 0.999 None 0.754 0.318 0.335661160332 gnomAD-4.0.0 1.59188E-06 None None None None N None 0 0 None 0 2.77285E-05 None 0 0 0 0 0
S/T 9510 Ig-81 18 rs2076392914 0.0775 None 0.007 None 0.1 0.073 0.0806252709748 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06868E-04 0
S/T 9510 Ig-81 18 rs2076392914 0.0775 None 0.007 None 0.1 0.073 0.0806252709748 gnomAD-4.0.0 6.56996E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.06868E-04 0
S/Y 9510 Ig-81 18 rs753125248 0.1665 -0.679 0.921 None 0.394 0.277 0.37762505005 gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
S/Y 9510 Ig-81 18 rs753125248 0.1665 -0.679 0.921 None 0.394 0.277 0.37762505005 gnomAD-4.0.0 1.16329E-05 None None None None N None 0 2.23644E-05 None 0 0 None 0 8.67453E-04 0 1.27536E-04 0
Y/C 9606 Ig-82 17 rs1408526622 0.1063 None 0.103 None 0.228 0.064 0.370240404367 gnomAD-4.0.0 1.59119E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85817E-06 0 0
Y/H 9606 Ig-82 17 None 0.1041 None 0.032 None 0.32 0.168 0.270447802918 gnomAD-4.0.0 2.05259E-06 None None None None N None 5.9755E-05 0 None 0 0 None 0 0 8.99465E-07 0 0
T/A 9714 Ig-83 17 None 0.1433 None 0.103 None 0.173 0.1 0.132336055621 gnomAD-4.0.0 1.60692E-06 None None None None I None 0 0 None 4.81371E-05 0 None 0 0 0 0 0
T/P 9714 Ig-83 17 None 0.3581 None 0.984 None 0.527 0.33 0.250579442822 gnomAD-4.0.0 1.60692E-06 None None None None I None 0 0 None 0 0 None 0 0 2.88319E-06 0 0
D/E 9916 Ig-84 17 rs990983452 0.2887 -0.544 None None 0.118 0.029 0.208816687407 gnomAD-2.1.1 4.06E-06 None None None None N None 0 2.92E-05 None 0 0 None 0 None 0 0 0
D/E 9916 Ig-84 17 rs990983452 0.2887 -0.544 None None 0.118 0.029 0.208816687407 gnomAD-4.0.0 6.85456E-07 None None None None N None 0 2.24296E-05 None 0 0 None 0 0 0 0 0
D/G 9916 Ig-84 17 rs768314420 0.4634 -0.584 0.22 None 0.449 0.196 0.225215365344 gnomAD-2.1.1 1.22E-05 None None None None N None 0 0 None 0 1.67485E-04 None 0 None 0 0 0
D/G 9916 Ig-84 17 rs768314420 0.4634 -0.584 0.22 None 0.449 0.196 0.225215365344 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92456E-04 None 0 0 0 0 0
D/G 9916 Ig-84 17 rs768314420 0.4634 -0.584 0.22 None 0.449 0.196 0.225215365344 gnomAD-4.0.0 5.14235E-06 None None None None N None 0 0 None 0 9.69556E-05 None 0 0 0 0 0
D/N 9916 Ig-84 17 None 0.1648 None 0.22 None 0.449 0.176 0.240491677333 gnomAD-4.0.0 1.59866E-06 None None None None N None 0 0 None 0 0 None 1.96665E-05 0 0 0 0
D/V 9916 Ig-84 17 rs768314420 0.4122 0.248 0.001 None 0.403 0.221 0.31411915649 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
D/V 9916 Ig-84 17 rs768314420 0.4122 0.248 0.001 None 0.403 0.221 0.31411915649 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92456E-04 None 0 0 0 0 0
D/V 9916 Ig-84 17 rs768314420 0.4122 0.248 0.001 None 0.403 0.221 0.31411915649 gnomAD-4.0.0 3.59965E-05 None None None None N None 0 0 None 0 6.78689E-04 None 0 0 0 0 0
T/I 10005 Ig-85 17 rs2075505818 0.2611 None 0.984 None 0.623 0.278 0.331876078066 gnomAD-4.0.0 1.59101E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85791E-06 0 0
S/P 10094 Ig-86 17 rs773164933 0.8479 -0.371 0.999 None 0.721 0.406 0.42538462244 gnomAD-2.1.1 1.2E-05 None None None None N None 0 8.69E-05 None 0 0 None 0 None 0 0 0
S/P 10094 Ig-86 17 rs773164933 0.8479 -0.371 0.999 None 0.721 0.406 0.42538462244 gnomAD-4.0.0 6.36345E-06 None None None None N None 0 9.14495E-05 None 0 0 None 0 0 0 0 0
P/L 13797 Ig-88 18 rs1205515315 0.4883 -0.436 0.999 N 0.741 0.363 0.297375071883 gnomAD-4.0.0 2.74024E-06 None None None None N None 0 0 None 0 0 None 0 0 3.60086E-06 0 0
T/I 13890 Ig-89 15 rs780566983 0.4811 -0.135 0.987 N 0.382 0.263 0.331365685468 gnomAD-2.1.1 4.41E-06 None None None None N None 0 0 None 0 0 None 3.59E-05 None 0 0 0
T/I 13890 Ig-89 15 rs780566983 0.4811 -0.135 0.987 N 0.382 0.263 0.331365685468 gnomAD-4.0.0 2.07224E-06 None None None None N None 0 0 None 0 0 None 0 3.47705E-04 0 1.19022E-05 0
T/R 13890 Ig-89 15 rs780566983 0.6752 -0.138 0.844 N 0.372 0.226 0.443999229985 gnomAD-4.0.0 1.38149E-06 None None None None N None 0 0 None 0 0 None 0 0 9.05315E-07 0 1.6695E-05
Q/K 14070 Ig-91 17 None 0.2415 None 0.997 N 0.424 0.372 0.246773566709 gnomAD-4.0.0 1.59226E-06 None None None None N None 0 2.28739E-05 None 0 0 None 0 0 0 0 0
T/A 14158 Ig-92 17 rs2060122664 0.0985 None 0.981 N 0.468 0.245 0.21737058555 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/A 14158 Ig-92 17 rs2060122664 0.0985 None 0.981 N 0.468 0.245 0.21737058555 gnomAD-4.0.0 6.57635E-06 None None None None N None 2.41278E-05 0 None 0 0 None 0 0 0 0 0
T/I 14158 Ig-92 17 rs373227762 0.2415 0.038 0.999 D 0.8 0.439 None gnomAD-2.1.1 2.15E-05 None None None None N None 4.13E-05 2.83E-05 None 0 0 None 0 None 0 3.14E-05 0
T/I 14158 Ig-92 17 rs373227762 0.2415 0.038 0.999 D 0.8 0.439 None gnomAD-3.1.2 1.97E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 2.94E-05 0 0
T/I 14158 Ig-92 17 rs373227762 0.2415 0.038 0.999 D 0.8 0.439 None gnomAD-4.0.0 6.26137E-05 None None None None N None 2.67258E-05 1.66811E-05 None 0 0 None 0 0 8.13921E-05 0 3.20379E-05
E/D 14247 Ig-93 17 rs1017956154 0.0853 None 0.001 N 0.113 0.064 0.132336055621 gnomAD-4.0.0 6.84493E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99628E-07 0 0
T/I 14335 Ig-94 17 None 0.3457 None 0.995 D 0.687 0.445 0.296329037015 gnomAD-4.0.0 3.18456E-06 None None None None N None 0 0 None 0 2.77762E-05 None 0 0 2.86025E-06 0 0
S/N 14513 Ig-96 17 rs557216748 0.0781 -0.148 None N 0.105 0.106 0.126345400529 gnomAD-2.1.1 3.43E-05 None None None None N None 0 0 None 0 0 None 2.81849E-04 None 0 0 0
S/N 14513 Ig-96 17 rs557216748 0.0781 -0.148 None N 0.105 0.106 0.126345400529 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 0 1.03734E-03 0
S/N 14513 Ig-96 17 rs557216748 0.0781 -0.148 None N 0.105 0.106 0.126345400529 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
S/N 14513 Ig-96 17 rs557216748 0.0781 -0.148 None N 0.105 0.106 0.126345400529 gnomAD-4.0.0 3.0546E-05 None None None None N None 0 0 None 0 0 None 0 1.65618E-04 0 5.27485E-04 1.60917E-05
S/T 14513 Ig-96 17 rs557216748 0.0789 None None N 0.116 0.103 0.0884992946249 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/T 14513 Ig-96 17 rs557216748 0.0789 None None N 0.116 0.103 0.0884992946249 gnomAD-4.0.0 1.24687E-06 None None None None N None 0 0 None 0 0 None 0 0 1.70224E-06 0 0
T/I 14691 Ig-98 17 rs1048028645 0.3659 None 0.999 D 0.721 0.427 0.313210971179 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 14691 Ig-98 17 rs1048028645 0.3659 None 0.999 D 0.721 0.427 0.313210971179 gnomAD-4.0.0 3.84595E-06 None None None None N None 3.38352E-05 1.69607E-05 None 0 0 None 0 0 0 0 0
T/K 14691 Ig-98 17 rs1048028645 0.4178 None 0.999 D 0.726 0.476 0.307966526162 gnomAD-4.0.0 1.59241E-06 None None None None N None 5.66123E-05 0 None 0 0 None 0 0 0 0 0
T/A 14780 Ig-99 16 rs1279825946 0.1404 -0.656 0.76 N 0.39 0.125 0.115124310173 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/A 14780 Ig-99 16 rs1279825946 0.1404 -0.656 0.76 N 0.39 0.125 0.115124310173 gnomAD-4.0.0 3.18617E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86156E-06 1.43328E-05 0
T/S 14869 Ig-100 17 None 0.1337 None 0.958 N 0.359 0.236 0.256793551483 gnomAD-4.0.0 1.20036E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31254E-06 0 0
M/T 14958 Ig-101 17 None 0.1175 None None N 0.091 0.072 0.200317383148 gnomAD-4.0.0 1.37397E-06 None None None None N None 0 0 None 0 0 None 0 0 9.01663E-07 1.17669E-05 0
T/P 15047 Ig-102 17 rs764583221 0.1547 -0.441 0.966 N 0.375 0.565 0.467923293426 gnomAD-2.1.1 4.06E-06 None None None None N None 0 2.92E-05 None 0 0 None 0 None 0 0 0
T/P 15047 Ig-102 17 rs764583221 0.1547 -0.441 0.966 N 0.375 0.565 0.467923293426 gnomAD-4.0.0 1.59476E-06 None None None None N None 0 2.29389E-05 None 0 0 None 0 0 0 0 0
K/N 15136 Ig-103 17 rs72677225 0.5008 -0.02 0.98 N 0.41 0.18 0.18274738541 gnomAD-2.1.1 5.05756E-03 None None None None N None 1.36861E-03 2.11103E-03 None 3.01146E-03 0 None 1.70704E-03 None 8.03277E-03 7.69595E-03 5.54135E-03
K/N 15136 Ig-103 17 rs72677225 0.5008 -0.02 0.98 N 0.41 0.18 0.18274738541 gnomAD-3.1.2 5.01086E-03 None None None None N None 1.35253E-03 1.57584E-03 0 2.30548E-03 0 None 6.97718E-03 6.32911E-03 8.43913E-03 2.48859E-03 5.74163E-03
K/N 15136 Ig-103 17 rs72677225 0.5008 -0.02 0.98 N 0.41 0.18 0.18274738541 1000 genomes 2.19649E-03 None None None None N None 0 1.4E-03 None None 0 8E-03 None None None 2E-03 None
K/N 15136 Ig-103 17 rs72677225 0.5008 -0.02 0.98 N 0.41 0.18 0.18274738541 gnomAD-4.0.0 6.65913E-03 None None None None N None 1.18816E-03 2.09072E-03 None 2.50372E-03 0 None 6.85532E-03 3.30688E-03 8.03316E-03 1.79231E-03 5.67726E-03
K/T 15136 Ig-103 17 None 0.2021 None 0.4 N 0.277 0.158 0.199424873507 gnomAD-4.0.0 3.19065E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72715E-06 0 0
E/K 15224 Ig-104 17 None 0.5696 None 0.999 N 0.584 0.38 0.223146558224 gnomAD-4.0.0 1.36951E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79977E-06 0 0
D/E 15407 Ig-106 17 rs370808856 0.4839 -0.235 0.893 N 0.308 0.147 0.341934017632 gnomAD-2.1.1 4.63E-06 None None None None N None 0 0 None 0 0 None 4.57E-05 None 0 0 0
D/E 15407 Ig-106 17 rs370808856 0.4839 -0.235 0.893 N 0.308 0.147 0.341934017632 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
D/E 15407 Ig-106 17 rs370808856 0.4839 -0.235 0.893 N 0.308 0.147 0.341934017632 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
D/E 15407 Ig-106 17 rs370808856 0.4839 -0.235 0.893 N 0.308 0.147 0.341934017632 gnomAD-4.0.0 1.27475E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.21717E-05 1.6547E-05
D/G 15407 Ig-106 17 rs375445028 0.6493 -0.589 0.998 D 0.71 0.572 0.49530441419 gnomAD-2.1.1 9.22E-06 None None None None N None 0 0 None 0 1.15274E-04 None 0 None 0 0 0
D/G 15407 Ig-106 17 rs375445028 0.6493 -0.589 0.998 D 0.71 0.572 0.49530441419 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94477E-04 None 0 0 0 0 0
D/G 15407 Ig-106 17 rs375445028 0.6493 -0.589 0.998 D 0.71 0.572 0.49530441419 gnomAD-4.0.0 1.22081E-05 None None None None N None 0 0 None 0 1.22808E-04 None 0 0 5.04938E-06 3.03389E-05 0
D/V 15496 Ig-107 17 rs755301020 0.7316 None 1.0 N 0.85 0.606 0.741726271847 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
P/L 15584 Ig-108 17 rs1170371957 0.1774 -0.08 1.0 N 0.779 0.451 0.456738291233 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
P/L 15584 Ig-108 17 rs1170371957 0.1774 -0.08 1.0 N 0.779 0.451 0.456738291233 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
P/L 15584 Ig-108 17 rs1170371957 0.1774 -0.08 1.0 N 0.779 0.451 0.456738291233 gnomAD-4.0.0 3.72432E-06 None None None None N None 1.33761E-05 0 None 0 0 None 0 0 4.24198E-06 0 0
P/S 15584 Ig-108 17 rs751925383 0.1517 -0.944 1.0 N 0.747 0.37 0.154104182512 gnomAD-2.1.1 1.08E-05 None None None None N None 1.24388E-04 0 None 0 0 None 0 None 0 0 0
P/S 15584 Ig-108 17 rs751925383 0.1517 -0.944 1.0 N 0.747 0.37 0.154104182512 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
P/S 15584 Ig-108 17 rs751925383 0.1517 -0.944 1.0 N 0.747 0.37 0.154104182512 gnomAD-4.0.0 1.31686E-05 None None None None N None 4.83232E-05 0 None 0 0 None 0 0 0 0 0
P/L 15979 Ig-109 12 rs184815126 0.3209 -0.313 1.0 N 0.766 0.406 None gnomAD-2.1.1 8.96E-05 None None None None N None 0 1.41547E-04 None 0 0 None 0 None 0 1.49336E-04 1.40885E-04
P/L 15979 Ig-109 12 rs184815126 0.3209 -0.313 1.0 N 0.766 0.406 None gnomAD-3.1.2 1.44859E-04 None None None None N None 2.41E-05 1.9698E-04 0 0 0 None 0 0 2.65088E-04 0 0
P/L 15979 Ig-109 12 rs184815126 0.3209 -0.313 1.0 N 0.766 0.406 None 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
P/L 15979 Ig-109 12 rs184815126 0.3209 -0.313 1.0 N 0.766 0.406 None gnomAD-4.0.0 1.19057E-04 None None None None N None 1.33461E-05 1.5016E-04 None 0 4.47227E-05 None 0 1.65344E-04 1.41633E-04 0 1.92252E-04
P/S 15979 Ig-109 12 rs1473380697 0.1929 -0.475 1.0 N 0.765 0.339 0.266843984389 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
P/S 15979 Ig-109 12 rs1473380697 0.1929 -0.475 1.0 N 0.765 0.339 0.266843984389 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
P/S 15979 Ig-109 12 rs1473380697 0.1929 -0.475 1.0 N 0.765 0.339 0.266843984389 gnomAD-4.0.0 6.58458E-06 None None None None N None 2.41488E-05 0 None 0 0 None 0 0 0 0 0
K/E 16275 Ig-110 14 None 0.3707 None 0.999 N 0.618 0.329 0.197625483188 gnomAD-4.0.0 6.84864E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00012E-07 0 0
K/N 16275 Ig-110 14 rs2056975496 0.5835 None 1.0 N 0.728 0.213 0.139678290688 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/N 16275 Ig-110 14 rs2056975496 0.5835 None 1.0 N 0.728 0.213 0.139678290688 gnomAD-4.0.0 4.3422E-06 None None None None N None 0 0 None 0 0 None 0 0 5.08889E-06 0 1.60369E-05
K/Q 16275 Ig-110 14 None 0.2101 None 1.0 N 0.701 0.3 0.181679512989 gnomAD-4.0.0 6.84864E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00012E-07 0 0
K/N 16971 Ig-111 17 None 0.2802 None 1.0 N 0.707 0.186 0.158396225186 gnomAD-4.0.0 1.59383E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86202E-06 0 0
E/K 17264 Ig-112 14 rs566710566 0.4167 -0.082 0.565 N 0.489 0.149 0.180583059064 gnomAD-2.1.1 4.05E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/K 17264 Ig-112 14 rs566710566 0.4167 -0.082 0.565 N 0.489 0.149 0.180583059064 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.57E-05 0 0 0 None 0 0 0 0 0
E/K 17264 Ig-112 14 rs566710566 0.4167 -0.082 0.565 N 0.489 0.149 0.180583059064 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
E/K 17264 Ig-112 14 rs566710566 0.4167 -0.082 0.565 N 0.489 0.149 0.180583059064 gnomAD-4.0.0 6.57652E-06 None None None None N None 0 6.55996E-05 None 0 0 None 0 0 0 0 0
T/A 17689 Ig-113 13 None 0.1462 None 0.91 N 0.478 0.142 0.154104182512 gnomAD-4.0.0 6.00164E-06 None None None None N None 0 0 None 0 0 None 0 0 6.56254E-06 0 0
P/A 17983 Ig-114 16 None 0.0608 None 0.4 N 0.319 0.14 0.177238962908 gnomAD-4.0.0 6.85439E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00403E-07 0 0
Q/K 18395 Ig-115 14 None 0.1041 None 0.166 N 0.22 0.109 0.0611884634855 gnomAD-4.0.0 1.59377E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86243E-06 0 0
N/D 18701 Ig-116 14 rs1001238 0.0583 0.171 None N 0.1 0.162 None gnomAD-2.1.1 3.54674E-01 None None None None N None 5.41211E-01 4.31485E-01 None 2.88348E-01 7.1154E-01 None 5.22932E-01 None 2.77491E-01 2.27833E-01 3.10017E-01
N/D 18701 Ig-116 14 rs1001238 0.0583 0.171 None N 0.1 0.162 None gnomAD-3.1.2 3.631E-01 None None None None N None 5.40248E-01 3.87211E-01 5.59341E-01 2.90611E-01 7.08757E-01 None 2.87323E-01 2.81646E-01 2.27012E-01 5.20747E-01 3.30932E-01
N/D 18701 Ig-116 14 rs1001238 0.0583 0.171 None N 0.1 0.162 None 1000 genomes 5.1278E-01 None None None None N None 5.688E-01 4.078E-01 None None 7.252E-01 2.535E-01 None None None 5.593E-01 None
N/D 18701 Ig-116 14 rs1001238 0.0583 0.171 None N 0.1 0.162 None gnomAD-4.0.0 2.78915E-01 None None None None N None 5.4686E-01 4.18557E-01 None 2.88409E-01 7.02305E-01 None 2.80055E-01 3.15589E-01 2.19149E-01 5.10058E-01 3.06389E-01
N/I 18701 Ig-116 14 None 0.2136 None 0.006 N 0.33 0.203 0.377976839388 gnomAD-4.0.0 6.86502E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.66279E-05
N/S 18701 Ig-116 14 rs917862808 0.0784 None None N 0.165 0.2 0.0611884634855 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
N/S 18701 Ig-116 14 rs917862808 0.0784 None None N 0.165 0.2 0.0611884634855 gnomAD-4.0.0 1.24324E-06 None None None None N None 0 1.68885E-05 None 0 0 None 0 0 0 0 1.60694E-05
V/A 19109 Ig-117 15 None 0.3739 None 0.973 N 0.502 0.159 0.260249123532 gnomAD-4.0.0 1.59251E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85981E-06 0 0
V/M 19109 Ig-117 15 rs945083650 0.2162 None 0.999 N 0.501 0.329 0.269111216191 gnomAD-4.0.0 9.5822E-06 None None None None I None 0 0 None 0 3.54108E-04 None 0 0 0 0 0
A/G 19403 Ig-118 13 rs573503792 0.1287 -0.578 0.027 N 0.336 0.175 None gnomAD-2.1.1 2.15E-05 None None None None N None 1.65317E-04 5.67E-05 None 0 0 None 0 None 0 0 0
A/G 19403 Ig-118 13 rs573503792 0.1287 -0.578 0.027 N 0.336 0.175 None gnomAD-3.1.2 5.92E-05 None None None None N None 1.9305E-04 6.56E-05 0 0 0 None 0 0 0 0 0
A/G 19403 Ig-118 13 rs573503792 0.1287 -0.578 0.027 N 0.336 0.175 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
A/G 19403 Ig-118 13 rs573503792 0.1287 -0.578 0.027 N 0.336 0.175 None gnomAD-4.0.0 1.05371E-05 None None None None N None 1.59949E-04 3.33645E-05 None 0 0 None 0 0 0 0 4.80292E-05
A/P 19403 Ig-118 13 rs545185154 0.1159 0.011 None N 0.233 0.229 None gnomAD-2.1.1 2.02E-05 None None None None N None 0 0 None 0 2.81405E-04 None 0 None 0 0 0
A/P 19403 Ig-118 13 rs545185154 0.1159 0.011 None N 0.233 0.229 None gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 9.7012E-04 None 0 0 0 0 0
A/P 19403 Ig-118 13 rs545185154 0.1159 0.011 None N 0.233 0.229 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
A/P 19403 Ig-118 13 rs545185154 0.1159 0.011 None N 0.233 0.229 None gnomAD-4.0.0 8.30571E-05 None None None None N None 0 0 None 0 2.97752E-03 None 0 0 0 0 1.60113E-05
A/V 19403 Ig-118 13 None 0.1459 None 0.117 N 0.324 0.149 0.317084106153 gnomAD-4.0.0 1.36878E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79917E-06 0 0
T/A 20786 Ig-122 18 None 0.0749 None 0.454 N 0.349 0.07 0.139678290688 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
T/N 20786 Ig-122 18 None 0.1032 None 0.801 N 0.33 0.16 0.318252033908 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/A 21191 Ig-123 15 None 0.2266 None 1.0 N 0.706 0.366 0.324986149311 gnomAD-4.0.0 3.42362E-06 None None None None I None 0 0 None 0 0 None 0 0 3.5996E-06 0 1.65793E-05
P/R 21191 Ig-123 15 rs1425522000 0.8008 0.061 1.0 N 0.758 0.455 0.423597194605 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.94E-06 0
P/R 21191 Ig-123 15 rs1425522000 0.8008 0.061 1.0 N 0.758 0.455 0.423597194605 gnomAD-4.0.0 1.594E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86244E-06 0 0
K/I 21483 Ig-124 15 None 0.6887 None 1.0 N 0.715 0.488 0.418221603839 gnomAD-4.0.0 6.85315E-07 None None None None N None 3.00643E-05 0 None 0 0 None 0 0 0 0 0
K/R 21483 Ig-124 15 rs1368411917 0.1514 -0.3 0.999 N 0.571 0.21 0.291694819147 gnomAD-2.1.1 8.1E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 1.66556E-04
K/R 21483 Ig-124 15 rs1368411917 0.1514 -0.3 0.999 N 0.571 0.21 0.291694819147 gnomAD-4.0.0 2.05595E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80076E-06 0 1.65915E-05
N/K 21880 Ig-125 15 None 0.6147 None 0.014 N 0.272 0.059 0.0884992946249 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.21507E-04 0
T/I 22278 Ig-126 14 rs1449367862 0.5391 -0.084 0.994 N 0.747 0.395 0.479286488449 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.95E-06 0
T/I 22278 Ig-126 14 rs1449367862 0.5391 -0.084 0.994 N 0.747 0.395 0.479286488449 gnomAD-4.0.0 7.96889E-06 None None None None I None 0 0 None 0 0 None 3.77017E-05 0 8.58595E-06 0 0
N/D 22567 Ig-127 8 rs2047147885 0.291 None 0.425 N 0.233 0.168 0.110078149338 gnomAD-4.0.0 6.43318E-06 None None None None N None 0 0 None 0 0 None 0 0 1.1548E-05 0 0
N/S 22567 Ig-127 8 None 0.0813 None 0.003 N 0.149 0.073 0.0986583533028 gnomAD-4.0.0 1.37442E-06 None None None None N None 0 0 None 0 0 None 0 0 9.0221E-07 0 1.66406E-05
T/P 22963 Ig-128 14 rs771761816 0.1511 -0.547 0.638 N 0.429 0.317 0.327419511103 gnomAD-2.1.1 4.46E-05 None None None None I None 0 2.90529E-04 None 0 0 None 0 None 0 0 1.67448E-04
T/P 22963 Ig-128 14 rs771761816 0.1511 -0.547 0.638 N 0.429 0.317 0.327419511103 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
T/P 22963 Ig-128 14 rs771761816 0.1511 -0.547 0.638 N 0.429 0.317 0.327419511103 gnomAD-4.0.0 1.12024E-05 None None None None I None 1.33469E-05 2.33754E-04 None 0 0 None 0 0 2.55204E-06 0 0
S/G 23361 Ig-129 17 rs751707858 0.2215 -0.781 0.822 N 0.465 0.216 0.199424873507 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
S/G 23361 Ig-129 17 rs751707858 0.2215 -0.781 0.822 N 0.465 0.216 0.199424873507 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/G 23361 Ig-129 17 rs751707858 0.2215 -0.781 0.822 N 0.465 0.216 0.199424873507 gnomAD-4.0.0 3.09898E-06 None None None None I None 0 0 None 0 0 None 0 0 4.23862E-06 0 0
S/N 23361 Ig-129 17 rs1433418101 0.392 None 0.822 N 0.448 0.173 0.141422826196 gnomAD-4.0.0 1.5918E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85938E-06 0 0
S/R 23361 Ig-129 17 None 0.9636 None 0.942 N 0.477 0.385 0.289474373501 gnomAD-4.0.0 6.84312E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99582E-07 0 0
N/K 23650 Ig-130 14 rs377185608 0.3052 0.308 0.027 N 0.336 0.061 0.0986583533028 gnomAD-2.1.1 2.52E-05 None None None None N None 2.07745E-04 2.85E-05 None 0 0 None 0 None 0 7.88E-06 0
N/K 23650 Ig-130 14 rs377185608 0.3052 0.308 0.027 N 0.336 0.061 0.0986583533028 gnomAD-3.1.2 5.26E-05 None None None None N None 1.44851E-04 0 0 0 0 None 0 0 1.47E-05 0 4.78011E-04
N/K 23650 Ig-130 14 rs377185608 0.3052 0.308 0.027 N 0.336 0.061 0.0986583533028 gnomAD-4.0.0 1.36425E-05 None None None None N None 2.00326E-04 3.33979E-05 None 0 0 None 0 0 2.54377E-06 0 3.20461E-05
A/V 24046 Ig-131 18 rs146767076 0.085 -0.15 None N 0.11 0.07 None gnomAD-2.1.1 4.65023E-04 None None None None N None 4.79854E-03 3.1165E-04 None 0 0 None 3.27E-05 None 0 7.83E-06 1.40766E-04
A/V 24046 Ig-131 18 rs146767076 0.085 -0.15 None N 0.11 0.07 None gnomAD-3.1.2 1.28881E-03 None None None None N None 4.44166E-03 6.55566E-04 0 0 0 None 0 3.16456E-03 1.47E-05 0 0
A/V 24046 Ig-131 18 rs146767076 0.085 -0.15 None N 0.11 0.07 None 1000 genomes 1.39776E-03 None None None None N None 5.3E-03 0 None None 0 0 None None None 0 None
A/V 24046 Ig-131 18 rs146767076 0.085 -0.15 None N 0.11 0.07 None gnomAD-4.0.0 2.36774E-04 None None None None N None 4.50619E-03 4.16833E-04 None 0 0 None 0 1.65125E-04 2.54323E-06 2.19621E-05 2.08147E-04
T/A 24445 Ig-132 15 None 0.1408 None 0.999 N 0.531 0.314 0.185906805712 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 24445 Ig-132 15 rs377334665 0.429 -0.041 1.0 N 0.805 0.384 None gnomAD-2.1.1 1.00167E-04 None None None None I None 4.13E-05 0 None 0 0 None 0 None 4E-05 2.03826E-04 0
T/I 24445 Ig-132 15 rs377334665 0.429 -0.041 1.0 N 0.805 0.384 None gnomAD-3.1.2 1.11822E-04 None None None None I None 4.83E-05 0 0 0 0 None 0 0 2.20621E-04 0 0
T/I 24445 Ig-132 15 rs377334665 0.429 -0.041 1.0 N 0.805 0.384 None gnomAD-4.0.0 2.11985E-04 None None None None I None 2.67144E-05 0 None 0 0 None 3.1248E-05 0 2.61951E-04 0 4.64431E-04
T/N 24445 Ig-132 15 rs377334665 0.1919 -0.724 1.0 N 0.797 0.346 0.302793454619 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 0 None 0 3.57E-05 0
T/N 24445 Ig-132 15 rs377334665 0.1919 -0.724 1.0 N 0.797 0.346 0.302793454619 gnomAD-4.0.0 2.05297E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69876E-06 0 0
D/E 24732 Ig-133 17 rs764541017 0.2949 None 0.958 N 0.422 0.2 0.177238962908 gnomAD-4.0.0 2.05349E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69892E-06 0 0
D/G 24732 Ig-133 17 None 0.3179 None 0.958 N 0.667 0.444 0.186928172975 gnomAD-4.0.0 1.5927E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85995E-06 0 0
D/H 24732 Ig-133 17 rs754089001 0.4991 -0.519 0.999 N 0.817 0.411 0.202086224978 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
D/H 24732 Ig-133 17 rs754089001 0.4991 -0.519 0.999 N 0.817 0.411 0.202086224978 gnomAD-4.0.0 6.8451E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99656E-07 0 0
D/N 24732 Ig-133 17 None 0.1224 -0.455 0.988 N 0.713 0.302 0.171388866994 gnomAD-4.0.0 1.36902E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99656E-07 1.15961E-05 0
S/T 25128 Ig-134 18 None 0.0683 None None N 0.121 0.099 0.0297737177859 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/Y 25814 Ig-136 17 rs1432951481 0.4022 -0.084 0.999 N 0.723 0.35 0.264547087235 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
D/Y 25814 Ig-136 17 rs1432951481 0.4022 -0.084 0.999 N 0.723 0.35 0.264547087235 gnomAD-4.0.0 5.47519E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19686E-06 0 0
T/I 26210 Ig-137 18 None 0.1978 None 0.989 N 0.749 0.41 0.405560941015 gnomAD-4.0.0 6.84563E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99705E-07 0 0
T/K 26210 Ig-137 18 rs879021950 0.4222 -0.387 0.957 N 0.677 0.33 None gnomAD-2.1.1 3.19E-05 None None None None I None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
T/K 26210 Ig-137 18 rs879021950 0.4222 -0.387 0.957 N 0.677 0.33 None gnomAD-3.1.2 1.31E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
T/K 26210 Ig-137 18 rs879021950 0.4222 -0.387 0.957 N 0.677 0.33 None gnomAD-4.0.0 2.48003E-06 None None None None I None 5.34217E-05 0 None 0 0 None 0 0 0 0 0
S/C 26609 Ig-138 16 rs771678075 0.1308 -0.227 0.997 N 0.576 0.401 0.404315859256 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
S/C 26609 Ig-138 16 rs771678075 0.1308 -0.227 0.997 N 0.576 0.401 0.404315859256 gnomAD-4.0.0 1.59151E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85878E-06 0 0
S/T 26609 Ig-138 16 rs1328705248 0.0928 -0.277 0.014 N 0.22 0.166 0.117506650769 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
S/T 26609 Ig-138 16 rs1328705248 0.0928 -0.277 0.014 N 0.22 0.166 0.117506650769 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/T 26609 Ig-138 16 rs1328705248 0.0928 -0.277 0.014 N 0.22 0.166 0.117506650769 gnomAD-4.0.0 6.57488E-06 None None None None N None 2.41289E-05 0 None 0 0 None 0 0 0 0 0
D/E 26896 Ig-139 17 None 0.2824 None 0.008 N 0.249 0.103 0.104622674875 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/V 26896 Ig-139 17 rs1705407272 0.3331 None 0.901 N 0.605 0.321 0.349204839081 gnomAD-4.0.0 7.96135E-06 None None None None N None 0 0 None 0 0 None 0 0 1.42975E-05 0 0
D/Y 26896 Ig-139 17 rs1327329522 0.291 -0.11 0.995 N 0.617 0.392 0.44750879378 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
D/Y 26896 Ig-139 17 rs1327329522 0.291 -0.11 0.995 N 0.617 0.392 0.44750879378 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/Y 26896 Ig-139 17 rs1327329522 0.291 -0.11 0.995 N 0.617 0.392 0.44750879378 gnomAD-4.0.0 2.56396E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78803E-06 0 0
T/A 27292 Ig-140 15 None 0.0768 None 0.835 N 0.459 0.205 0.240491677333 gnomAD-4.0.0 6.84442E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99463E-07 0 0
T/I 27292 Ig-140 15 rs1060500393 0.1589 0.06 0.994 N 0.539 0.442 0.388970301349 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
T/I 27292 Ig-140 15 rs1060500393 0.1589 0.06 0.994 N 0.539 0.442 0.388970301349 gnomAD-4.0.0 1.30049E-05 None None None None I None 0 0 None 0 0 None 0 0 1.70897E-05 0 0
T/P 27292 Ig-140 15 rs1421947280 0.0997 -0.395 0.994 N 0.537 0.322 0.310458034454 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
T/P 27292 Ig-140 15 rs1421947280 0.0997 -0.395 0.994 N 0.537 0.322 0.310458034454 gnomAD-4.0.0 3.42221E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49732E-06 0 0
T/S 27292 Ig-140 15 None 0.0962 None 0.489 N 0.144 0.1 0.165133752707 gnomAD-4.0.0 2.0534E-06 None None None None I None 0 0 None 0 0 None 0 3.46741E-04 0 0 1.65656E-05
Q/R 27979 Ig-142 17 rs755935124 0.1359 0.341 None N 0.211 0.137 None gnomAD-2.1.1 8.09E-06 None None None None N None 0 2.92E-05 None 0 0 None 0 None 0 8.94E-06 0
Q/R 27979 Ig-142 17 rs755935124 0.1359 0.341 None N 0.211 0.137 None gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
Q/R 27979 Ig-142 17 rs755935124 0.1359 0.341 None N 0.211 0.137 None gnomAD-4.0.0 9.92063E-06 None None None None N None 1.33615E-05 1.67029E-05 None 0 0 None 0 0 1.0174E-05 0 3.20441E-05
V/A 28374 Ig-143 17 rs777681919 0.1353 -1.21 0.027 N 0.299 0.065 0.221734844693 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/A 28374 Ig-143 17 rs777681919 0.1353 -1.21 0.027 N 0.299 0.065 0.221734844693 gnomAD-4.0.0 1.59111E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
V/D 28374 Ig-143 17 rs777681919 0.2015 -0.844 0.317 N 0.433 0.16 0.485634191555 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.67E-05 0
V/D 28374 Ig-143 17 rs777681919 0.2015 -0.844 0.317 N 0.433 0.16 0.485634191555 gnomAD-4.0.0 9.54666E-06 None None None None I None 0 0 None 0 0 None 0 0 1.71482E-05 0 0
V/I 28374 Ig-143 17 None 0.0761 None None N 0.115 0.055 0.0884992946249 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
S/L 28771 Ig-144 17 rs760184584 0.1943 -0.043 0.698 N 0.456 0.438 0.514811571519 gnomAD-2.1.1 8.12E-06 None None None None I None 0 0 None 0 1.11371E-04 None 0 None 0 0 0
S/L 28771 Ig-144 17 rs760184584 0.1943 -0.043 0.698 N 0.456 0.438 0.514811571519 gnomAD-4.0.0 3.19947E-06 None None None None I None 0 0 None 0 5.54723E-05 None 0 0 0 0 0
S/P 28771 Ig-144 17 rs369269686 0.1829 -0.024 0.97 N 0.487 0.335 None gnomAD-2.1.1 1.44E-05 None None None None I None 1.65344E-04 0 None 0 0 None 0 None 0 0 0
S/P 28771 Ig-144 17 rs369269686 0.1829 -0.024 0.97 N 0.487 0.335 None gnomAD-3.1.2 2.63E-05 None None None None I None 9.65E-05 0 0 0 0 None 0 0 0 0 0
S/P 28771 Ig-144 17 rs369269686 0.1829 -0.024 0.97 N 0.487 0.335 None gnomAD-4.0.0 5.58885E-06 None None None None I None 1.20163E-04 0 None 0 0 None 0 0 0 0 0
N/D 29061 Ig-145 17 rs755378840 0.1791 None 0.994 N 0.496 0.37 0.223146558224 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/D 29061 Ig-145 17 rs755378840 0.1791 None 0.994 N 0.496 0.37 0.223146558224 gnomAD-4.0.0 3.09851E-06 None None None None I None 0 0 None 0 0 None 0 0 4.23786E-06 0 0
N/S 29061 Ig-145 17 None 0.0812 None 0.978 N 0.525 0.159 0.136095386433 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
N/Y 29061 Ig-145 17 rs755378840 0.2517 -0.476 0.999 N 0.657 0.449 0.352262096564 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
N/Y 29061 Ig-145 17 rs755378840 0.2517 -0.476 0.999 N 0.657 0.449 0.352262096564 gnomAD-4.0.0 6.84244E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99441E-07 0 0
S/T 29457 Ig-146 14 rs1436729159 0.0771 None 0.016 N 0.167 0.064 0.124217242631 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92901E-04 None 0 0 0 0 0
S/T 29457 Ig-146 14 rs1436729159 0.0771 None 0.016 N 0.167 0.064 0.124217242631 gnomAD-4.0.0 6.5722E-06 None None None None N None 0 0 None 0 1.92901E-04 None 0 0 0 0 0
D/E 29856 Ig-147 15 None 0.2275 None 0.989 N 0.451 0.151 0.262175524916 gnomAD-4.0.0 6.88879E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00946E-07 0 0
D/Y 29856 Ig-147 15 rs1244755099 0.2313 -0.021 1.0 N 0.617 0.289 0.435590266561 gnomAD-2.1.1 4.13E-06 None None None None I None 0 0 None 0 0 None 3.29E-05 None 0 0 0
D/Y 29856 Ig-147 15 rs1244755099 0.2313 -0.021 1.0 N 0.617 0.289 0.435590266561 gnomAD-4.0.0 1.61856E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43575E-05 0
N/S 30148 Ig-148 17 rs1699818097 0.1052 None 0.999 N 0.545 0.353 0.193865811164 gnomAD-4.0.0 3.20853E-06 None None None None I None 0 0 None 0 0 None 0 0 2.89133E-06 0 3.04692E-05
S/R 30543 Ig-149 12 rs1043582121 0.8499 -0.17 0.901 N 0.523 0.284 0.186928172975 gnomAD-4.0.0 4.1057E-06 None None None None I None 0 4.47247E-05 None 0 0 None 0 0 3.59825E-06 0 0
S/R 30942 Ig-150 16 rs1575477437 0.8247 None 0.968 N 0.406 0.24 0.272639205421 gnomAD-4.0.0 6.84699E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99463E-07 0 0
D/A 31632 Ig-152 12 None 0.6032 None 1.0 N 0.729 0.493 0.282575091529 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/P 32031 Ig-153 15 None 0.2734 None 0.949 N 0.391 0.244 0.212008924253 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/L 32323 Ig-154 17 rs1695272344 0.2235 None 0.999 N 0.781 0.356 0.506311303838 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
P/L 32323 Ig-154 17 rs1695272344 0.2235 None 0.999 N 0.781 0.356 0.506311303838 gnomAD-4.0.0 6.57341E-06 None None None None N None 0 6.54879E-05 None 0 0 None 0 0 0 0 0
V/I 32721 Ig-155 14 rs533651182 0.1053 -0.088 0.973 N 0.501 0.2 None gnomAD-2.1.1 3.62E-05 None None None None I None 6.46E-05 0 None 9.95E-05 1.11321E-04 None 6.54E-05 None 0 2.67E-05 0
V/I 32721 Ig-155 14 rs533651182 0.1053 -0.088 0.973 N 0.501 0.2 None gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.92753E-04 None 0 0 0 0 0
V/I 32721 Ig-155 14 rs533651182 0.1053 -0.088 0.973 N 0.501 0.2 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
V/I 32721 Ig-155 14 rs533651182 0.1053 -0.088 0.973 N 0.501 0.2 None gnomAD-4.0.0 1.98298E-05 None None None None I None 2.66674E-05 0 None 3.37815E-05 4.45752E-05 None 0 3.30142E-04 1.94955E-05 2.19587E-05 0
A/P 33117 Ig-156 17 rs878926959 0.105 None 0.001 N 0.186 0.135 0.162503812791 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
A/P 33117 Ig-156 17 rs878926959 0.105 None 0.001 N 0.186 0.135 0.162503812791 gnomAD-4.0.0 6.57134E-06 None None None None N None 0 6.54536E-05 None 0 0 None 0 0 0 0 0
A/S 33117 Ig-156 17 rs878926959 0.0951 -0.555 None N 0.121 0.111 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
A/S 33117 Ig-156 17 rs878926959 0.0951 -0.555 None N 0.121 0.111 None gnomAD-4.0.0 1.59213E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85987E-06 0 0
A/T 33117 Ig-156 17 None 0.0825 None 0.144 N 0.351 0.066 0.124217242631 gnomAD-4.0.0 1.59213E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43332E-05 0
T/I 33213 Ig-157 11 None 0.3499 None 0.998 N 0.501 0.384 0.400033932507 gnomAD-4.0.0 1.59133E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
N/Y 33512 Ig-158 17 rs778965506 0.5085 -0.69 0.844 N 0.434 0.413 None gnomAD-2.1.1 2.51E-05 None None None None N None 0 0 None 0 0 None 0 None 0 5.5E-05 0
N/Y 33512 Ig-158 17 rs778965506 0.5085 -0.69 0.844 N 0.434 0.413 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
N/Y 33512 Ig-158 17 rs778965506 0.5085 -0.69 0.844 N 0.434 0.413 None gnomAD-4.0.0 5.45485E-05 None None None None N None 1.33483E-05 0 None 0 0 None 0 0 7.29088E-05 0 1.6019E-05
V/G 33612 Ig-159 17 None 0.4997 None 0.545 N 0.391 0.136 0.388334884743 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
H/L 34152 Ig-160 16 None 0.1679 None 0.012 N 0.353 0.068 0.282179105231 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/Q 34152 Ig-160 16 rs758384544 0.192 -0.185 0.055 N 0.194 0.055 0.159798565429 gnomAD-2.1.1 7.23E-05 None None None None N None 0 0 None 0 0 None 5.88197E-04 None 0 0 0
H/Q 34152 Ig-160 16 rs758384544 0.192 -0.185 0.055 N 0.194 0.055 0.159798565429 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 0 4.14079E-04 0
H/Q 34152 Ig-160 16 rs758384544 0.192 -0.185 0.055 N 0.194 0.055 0.159798565429 gnomAD-4.0.0 3.59395E-05 None None None None N None 0 0 None 0 0 None 0 0 0 6.36747E-04 0
H/R 34152 Ig-160 16 None 0.1407 None None N 0.153 0.089 0.112648838833 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 6.07533E-05 0
N/H 34274 Ig-161 17 rs748399505 0.1489 -0.85 0.004 N 0.203 0.097 0.0954503805726 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 1.63388E-04 None 0 0 0
N/H 34274 Ig-161 17 rs748399505 0.1489 -0.85 0.004 N 0.203 0.097 0.0954503805726 gnomAD-4.0.0 1.11369E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.00289E-04 0
S/G 34379 Ig-162 17 rs758051666 0.2335 None 0.811 N 0.427 0.352 0.263140351381 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/G 34379 Ig-162 17 rs758051666 0.2335 None 0.811 N 0.427 0.352 0.263140351381 gnomAD-4.0.0 6.56927E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
S/N 34379 Ig-162 17 None 0.3159 None 0.026 N 0.23 0.158 0.159798565429 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/R 34379 Ig-162 17 rs758051666 0.9332 -0.141 0.968 N 0.525 0.513 0.297375071883 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
S/T 35145 Ig-164 17 rs768379481 0.0704 -0.319 None N 0.118 0.031 0.0297737177859 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/T 35145 Ig-164 17 rs768379481 0.0704 -0.319 None N 0.118 0.031 0.0297737177859 gnomAD-4.0.0 1.59087E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
R/I 35623 Ig-167 17 rs777105439 0.2012 0.369 0.033 N 0.53 0.088 0.215109475489 gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 1.11297E-04 None 0 None 0 0 0
R/S 35623 Ig-167 17 None 0.3353 None None N 0.159 0.056 0.0954503805726 gnomAD-4.0.0 6.84143E-07 None None None None N None 0 0 None 0 0 None 0 0 8.994E-07 0 0
V/A 35913 Ig-169 17 rs771568319 0.635 -2.45 0.822 N 0.386 0.129 0.348983352498 gnomAD-2.1.1 1.61E-05 None None None -0.696(OBSL1) -1.085(OBSCN) N None 0 0 None 0 0 None 0 None 0 3.56E-05 0
V/A 35913 Ig-169 17 rs771568319 0.635 -2.45 0.822 N 0.386 0.129 0.348983352498 gnomAD-4.0.0 6.37144E-06 None None None -0.696(OBSL1) -1.085(OBSCN) N None 0 0 None 0 0 None 0 0 1.14477E-05 0 0
V/F 35913 Ig-169 17 rs1468593257 0.5036 -1.45 0.032 N 0.238 0.138 0.43912465853 gnomAD-2.1.1 4.03E-06 None None None 0.321(OBSL1) 0.069(OBSCN) N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
V/F 35913 Ig-169 17 rs1468593257 0.5036 -1.45 0.032 N 0.238 0.138 0.43912465853 gnomAD-4.0.0 1.59292E-06 None None None 0.321(OBSL1) 0.069(OBSCN) N None 0 0 None 0 0 None 0 0 2.862E-06 0 0
V/I 35913 Ig-169 17 None 0.1324 None 0.058 N 0.273 0.084 0.209622950755 gnomAD-4.0.0 1.59292E-06 None None None -0.691(OBSL1) -1.06(OBSCN) N None 0 0 None 0 0 None 0 2.4108E-04 0 0 0
V/L 35913 Ig-169 17 rs1468593257 0.5841 None 0.489 N 0.355 0.098 0.167679373172 gnomAD-3.1.2 6.57E-06 None None None -0.691(OBSL1) -1.06(OBSCN) N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/L 35913 Ig-169 17 rs1468593257 0.5841 None 0.489 N 0.355 0.098 0.167679373172 gnomAD-4.0.0 6.57056E-06 None None None -0.691(OBSL1) -1.06(OBSCN) N None 2.41324E-05 0 None 0 0 None 0 0 0 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.