Structural position:

  • Domain Type: Ig
  • Aligned Position: 33
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand B

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
A/V 27 Ig-1 22 rs760167840 0.4896 -0.006 1.0 N 0.761 0.455 0.638501922959 gnomAD-2.1.1 1.2E-05 None None None -0.942(TCAP) N None 6.16E-05 5.79E-05 None 0 0 None 0 None 0 0 0
A/V 27 Ig-1 22 rs760167840 0.4896 -0.006 1.0 N 0.761 0.455 0.638501922959 gnomAD-3.1.2 1.97E-05 None None None -0.942(TCAP) N None 4.83E-05 6.54E-05 0 0 0 None 0 0 0 0 0
A/V 27 Ig-1 22 rs760167840 0.4896 -0.006 1.0 N 0.761 0.455 0.638501922959 gnomAD-4.0.0 8.96567E-06 None None None -0.942(TCAP) N None 5.07408E-05 6.77828E-05 None 0 0 None 0 0 0 0 0
V/L 125 Ig-2 22 rs368101663 0.8403 -0.123 0.987 D 0.715 0.498 0.613002003054 gnomAD-2.1.1 7.09E-06 None None None -1.054(TCAP) N None 8.01E-05 0 None 0 0 None 0 None 0 0 0
V/L 125 Ig-2 22 rs368101663 0.8403 -0.123 0.987 D 0.715 0.498 0.613002003054 gnomAD-3.1.2 1.31E-05 None None None -1.054(TCAP) N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
V/L 125 Ig-2 22 rs368101663 0.8403 -0.123 0.987 D 0.715 0.498 0.613002003054 gnomAD-4.0.0 1.31413E-05 None None None -1.054(TCAP) N None 4.82532E-05 0 None 0 0 None 0 0 0 0 0
V/M 125 Ig-2 22 None 0.8445 None 1.0 D 0.811 0.514 0.641369747695 gnomAD-4.0.0 1.59222E-06 None None None -1.459(TCAP) N None 0 0 None 0 2.77377E-05 None 0 0 0 0 0
C/S 964 Ig-3 22 rs1195488045 0.9794 -2.256 1.0 D 0.794 0.855 0.868789883015 gnomAD-2.1.1 3.99E-06 None None disulfide None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
C/S 964 Ig-3 22 rs1195488045 0.9794 -2.256 1.0 D 0.794 0.855 0.868789883015 gnomAD-4.0.0 1.59057E-06 None None disulfide None N None 0 2.28624E-05 None 0 0 None 0 0 0 0 0
C/G 1103 Ig-4 22 None 0.8806 None 1.0 D 0.899 0.739 0.822118996963 gnomAD-4.0.0 1.5905E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85649E-06 0 0
C/Y 1103 Ig-4 22 None 0.988 None 1.0 D 0.927 0.709 0.768810578512 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
C/Y 1312 Ig-5 22 None 0.9784 None 1.0 D 0.934 0.73 0.803501258299 gnomAD-4.0.0 2.40083E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62522E-06 0 0
L/F 1478 Ig-6 22 rs1175803570 0.6558 -1.625 1.0 N 0.839 0.515 0.594452868026 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.82E-06 0
L/F 1478 Ig-6 22 rs1175803570 0.6558 -1.625 1.0 N 0.839 0.515 0.594452868026 gnomAD-4.0.0 1.36821E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79866E-06 0 0
C/G 1862 Ig-9 22 rs2092215973 0.8591 None 0.968 D 0.843 0.496 0.823553591755 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 1.01626E-03 None 0 0 None 0 0 0 0 0
C/S 1862 Ig-9 22 None 0.923 None 0.811 D 0.765 0.388 0.645225581225 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/F 2099 Ig-10 22 rs1055695339 0.9127 None 0.82 D 0.817 0.614 None gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
V/F 2099 Ig-10 22 rs1055695339 0.9127 None 0.82 D 0.817 0.614 None gnomAD-4.0.0 1.97182E-05 None None None None N None 7.23798E-05 0 None 0 0 None 0 0 0 0 0
C/R 2196 Ig-11 23 None 0.9984 None 1.0 D 0.945 0.653 0.624607077081 gnomAD-4.0.0 1.20032E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
C/S 2196 Ig-11 23 None 0.982 None 1.0 D 0.837 0.604 0.443285836454 gnomAD-4.0.0 1.20032E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
C/Y 2196 Ig-11 23 rs878854326 0.9922 -1.702 1.0 D 0.943 0.572 0.483670899158 gnomAD-2.1.1 7.09E-06 None None disulfide None N None 0 5.65E-05 None 0 0 None 0 None 0 0 0
C/Y 2196 Ig-11 23 rs878854326 0.9922 -1.702 1.0 D 0.943 0.572 0.483670899158 gnomAD-3.1.2 1.31E-05 None None disulfide None N None 0 1.30976E-04 0 0 0 None 0 0 0 0 0
C/Y 2196 Ig-11 23 rs878854326 0.9922 -1.702 1.0 D 0.943 0.572 0.483670899158 gnomAD-4.0.0 6.40379E-06 None None disulfide None N None 0 6.77897E-05 None 0 0 None 0 0 2.39186E-06 0 0
C/G 2466 Ig-14 22 None 0.2552 None 0.27 D 0.717 0.425 0.752941661959 gnomAD-4.0.0 6.84111E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99321E-07 0 0
C/S 2466 Ig-14 22 None 0.4299 None 0.01 D 0.568 0.367 0.613482770441 gnomAD-4.0.0 6.84111E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99321E-07 0 0
C/Y 2466 Ig-14 22 None 0.917 None 0.975 D 0.799 0.549 0.779765242688 gnomAD-4.0.0 1.36822E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79864E-06 0 0
V/I 2554 Ig-15 22 None 0.2181 None 0.997 N 0.547 0.259 0.404315859256 gnomAD-4.0.0 6.84144E-07 None None None None N None 0 2.23704E-05 None 0 0 None 0 0 0 0 0
V/L 2554 Ig-15 22 None 0.8366 None 0.997 N 0.659 0.259 0.348764635752 gnomAD-4.0.0 6.84144E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99327E-07 0 0
C/R 2641 Ig-16 21 rs762210511 0.9958 -1.606 1.0 D 0.913 0.645 0.505885190548 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
C/R 2641 Ig-16 21 rs762210511 0.9958 -1.606 1.0 D 0.913 0.645 0.505885190548 gnomAD-4.0.0 1.59087E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
V/I 2816 Ig-18 22 None 0.1127 None 0.012 N 0.443 0.131 0.295623431141 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
V/M 2990 Ig-20 22 rs746946974 0.841 -0.861 1.0 D 0.805 0.269 0.324161360171 gnomAD-2.1.1 2.39E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.4E-05 1.63132E-04
V/M 2990 Ig-20 22 rs746946974 0.841 -0.861 1.0 D 0.805 0.269 0.324161360171 gnomAD-4.0.0 3.42052E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49652E-06 0 0
C/R 3079 Ig-21 22 rs141259583 0.9987 -1.809 0.018 D 0.717 0.46 None gnomAD-2.1.1 7.08E-06 None None None None N None 8.01E-05 0 None 0 0 None 0 None 0 0 0
C/R 3079 Ig-21 22 rs141259583 0.9987 -1.809 0.018 D 0.717 0.46 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
C/R 3079 Ig-21 22 rs141259583 0.9987 -1.809 0.018 D 0.717 0.46 None gnomAD-4.0.0 3.04475E-06 None None None None N None 3.49479E-05 0 None 0 0 None 0 5.16529E-04 0 0 0
C/Y 3079 Ig-21 22 rs2154341551 0.992 None 0.983 D 0.839 0.535 0.515036129008 gnomAD-4.0.0 1.36816E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79859E-06 0 0
F/S 3168 Ig-22 22 None 0.9979 None 1.0 N 0.893 0.481 0.490560587058 gnomAD-4.0.0 3.18147E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71324E-06 0 0
F/V 3168 Ig-22 22 rs746038856 0.9608 -2.278 1.0 N 0.814 0.43 0.516437024119 gnomAD-2.1.1 1.2E-05 None None None None N None 0 8.68E-05 None 0 0 None 0 None 0 0 0
F/V 3168 Ig-22 22 rs746038856 0.9608 -2.278 1.0 N 0.814 0.43 0.516437024119 gnomAD-4.0.0 3.18149E-06 None None None None N None 0 4.57373E-05 None 0 0 None 0 0 0 0 0
A/P 3260 Ig-23 22 None 0.944 None 0.949 D 0.812 0.573 0.519728874731 gnomAD-4.0.0 1.5907E-06 None None None None N None 0 2.28686E-05 None 0 0 None 0 0 0 0 0
C/S 3366 Ig-24 22 None 0.7745 None 1.0 D 0.827 0.913 0.855352521839 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
C/Y 3366 Ig-24 22 None 0.9184 None 1.0 D 0.925 0.933 0.88699186517 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/E 3486 Ig-25 22 rs374093805 0.9835 -2.844 None None None 0.36 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
A/E 3486 Ig-25 22 rs374093805 0.9835 -2.844 None None None 0.36 None gnomAD-4.0.0 1.36845E-06 None None None None N None 0 2.23614E-05 None 0 0 None 0 0 8.99509E-07 0 0
A/T 3486 Ig-25 22 rs2087755569 0.2657 None None None None 0.266 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
A/T 3486 Ig-25 22 rs2087755569 0.2657 None None None None 0.266 None gnomAD-4.0.0 6.57298E-06 None None None None N None 0 6.54879E-05 None 0 0 None 0 0 0 0 0
A/V 3486 Ig-25 22 rs374093805 0.3422 -0.326 None None None 0.322 None gnomAD-2.1.1 1.67779E-04 None None None None N None 8.27E-05 0 None 0 0 None 1.4381E-03 None 0 7.81E-06 0
A/V 3486 Ig-25 22 rs374093805 0.3422 -0.326 None None None 0.322 None gnomAD-3.1.2 3.29E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 4.13736E-04 0
A/V 3486 Ig-25 22 rs374093805 0.3422 -0.326 None None None 0.322 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
A/V 3486 Ig-25 22 rs374093805 0.3422 -0.326 None None None 0.322 None gnomAD-4.0.0 7.684E-05 None None None None N None 7.99829E-05 0 None 0 0 None 0 0 9.32414E-06 1.13087E-03 6.40205E-05
C/F 3681 Ig-26 22 None 0.5826 None None None None 0.232 None gnomAD-4.0.0 6.84218E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65651E-05
C/Y 3681 Ig-26 22 None 0.8236 None None None None 0.321 None gnomAD-4.0.0 1.36844E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79889E-06 0 0
V/I 3841 Ig-27 22 rs755132807 0.1339 -0.178 0.997 N 0.588 0.339 None gnomAD-2.1.1 2.14E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 3.91E-05 0
V/I 3841 Ig-27 22 rs755132807 0.1339 -0.178 0.997 N 0.588 0.339 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
V/I 3841 Ig-27 22 rs755132807 0.1339 -0.178 0.997 N 0.588 0.339 None gnomAD-4.0.0 2.35496E-05 None None None None N None 1.33501E-05 0 None 0 0 None 0 1.64366E-04 2.20387E-05 8.78291E-05 3.20266E-05
C/S 4721 Ig-30 22 rs760530704 0.7864 -1.631 1.0 N 0.836 0.7 0.785099988397 gnomAD-2.1.1 4.03E-06 None None disulfide None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
C/S 4721 Ig-30 22 rs760530704 0.7864 -1.631 1.0 N 0.836 0.7 0.785099988397 gnomAD-3.1.2 6.57E-06 None None disulfide None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
C/S 4721 Ig-30 22 rs760530704 0.7864 -1.631 1.0 N 0.836 0.7 0.785099988397 gnomAD-4.0.0 2.73743E-06 None None disulfide None N None 0 0 None 0 2.5264E-05 None 0 0 0 3.47915E-05 0
C/W 4816 Ig-31 22 rs2154314532 0.9782 None 0.999 D 0.847 0.423 0.741552916196 gnomAD-3.1.2 6.57E-06 None None disulfide None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
C/W 4816 Ig-31 22 rs2154314532 0.9782 None 0.999 D 0.847 0.423 0.741552916196 gnomAD-4.0.0 4.05918E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 4.81972E-06 0 0
C/F 4909 Ig-32 22 None 0.4319 None 0.859 D 0.87 0.487 0.776434072436 gnomAD-4.0.0 6.84226E-07 None None disulfide None N None 0 0 None 0 0 None 0 0 8.99454E-07 0 0
C/Y 4909 Ig-32 22 rs188073989 0.6643 None 0.859 N 0.88 0.532 0.663756110175 gnomAD-4.0.0 6.84226E-07 None None disulfide None N None 0 0 None 0 0 None 0 0 8.99454E-07 0 0
C/W 5003 Ig-33 23 None 0.9914 None 1.0 D 0.906 0.615 0.725098580597 gnomAD-4.0.0 1.36977E-06 None None disulfide None N None 0 0 None 0 2.52985E-05 None 0 0 9.00067E-07 0 0
C/Y 5003 Ig-33 23 rs374015538 0.9801 -1.681 1.0 D 0.922 0.74 None gnomAD-2.1.1 2.04E-05 None None disulfide None N None 1.30617E-04 0 None 0 1.1443E-04 None 0 None 0 0 1.68577E-04
C/Y 5003 Ig-33 23 rs374015538 0.9801 -1.681 1.0 D 0.922 0.74 None gnomAD-3.1.2 6.57E-06 None None disulfide None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
C/Y 5003 Ig-33 23 rs374015538 0.9801 -1.681 1.0 D 0.922 0.74 None gnomAD-4.0.0 6.41802E-06 None None disulfide None N None 1.69165E-05 0 None 0 4.86784E-05 None 0 0 2.39743E-06 0 2.8503E-05
C/R 5096 Ig-34 22 None 0.9968 None 0.997 D 0.869 0.93 0.93170409529 gnomAD-4.0.0 2.74299E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 3.60425E-06 0 0
C/Y 5096 Ig-34 22 rs761022854 0.9798 -1.228 0.4 D 0.702 0.743 0.857939549357 gnomAD-2.1.1 4.07E-06 None None disulfide None N None 0 0 None 0 0 None 0 None 0 8.98E-06 0
C/Y 5096 Ig-34 22 rs761022854 0.9798 -1.228 0.4 D 0.702 0.743 0.857939549357 gnomAD-3.1.2 6.57E-06 None None disulfide None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
C/Y 5096 Ig-34 22 rs761022854 0.9798 -1.228 0.4 D 0.702 0.743 0.857939549357 gnomAD-4.0.0 6.43041E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 9.61358E-06 0 2.85209E-05
Y/C 5282 Ig-36 22 rs1253364524 0.1564 None 0.002 N 0.514 0.26 0.0611884634855 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
Y/C 5282 Ig-36 22 rs1253364524 0.1564 None 0.002 N 0.514 0.26 0.0611884634855 gnomAD-4.0.0 6.40494E-06 None None None None N None 0 0 None 0 0 None 0 0 1.19649E-05 0 0
Y/D 5282 Ig-36 22 rs1438275064 0.9105 -3.303 0.81 N 0.81 0.423 0.500868654924 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
Y/D 5282 Ig-36 22 rs1438275064 0.9105 -3.303 0.81 N 0.81 0.423 0.500868654924 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Y/D 5282 Ig-36 22 rs1438275064 0.9105 -3.303 0.81 N 0.81 0.423 0.500868654924 gnomAD-4.0.0 2.56281E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78657E-06 0 0
C/F 5378 Ig-37 22 None 0.9067 None 1.0 D 0.925 0.522 0.871708247235 gnomAD-4.0.0 6.84426E-07 None None disulfide None N None 0 0 None 0 0 None 0 0 0 0 1.65711E-05
C/R 5378 Ig-37 22 None 0.995 None 1.0 D 0.937 0.655 0.887764328481 gnomAD-4.0.0 1.20032E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
C/Y 5378 Ig-37 22 rs754271006 0.9825 -1.846 1.0 D 0.935 0.541 0.822912675618 gnomAD-2.1.1 4.03E-06 None None disulfide None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
C/Y 5378 Ig-37 22 rs754271006 0.9825 -1.846 1.0 D 0.935 0.541 0.822912675618 gnomAD-4.0.0 1.36885E-06 None None disulfide None N None 0 2.23914E-05 None 0 0 None 0 0 8.99607E-07 0 0
S/G 5471 Ig-38 22 rs757968547 0.1064 -1.595 0.002 N 0.335 0.185 0.0954503805726 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 3.3E-05 None 0 0 0
S/G 5471 Ig-38 22 rs757968547 0.1064 -1.595 0.002 N 0.335 0.185 0.0954503805726 gnomAD-4.0.0 3.18946E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.8748E-05 0
S/N 5471 Ig-38 22 rs749906091 0.5601 -1.159 0.642 N 0.627 0.202 0.141422826196 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 3.3E-05 None 0 0 0
S/N 5471 Ig-38 22 rs749906091 0.5601 -1.159 0.642 N 0.627 0.202 0.141422826196 gnomAD-4.0.0 4.78435E-06 None None None None N None 0 0 None 0 2.78288E-05 None 0 0 2.86341E-06 1.43773E-05 0
C/S 5565 Ig-39 23 rs1228967454 0.7128 -2.29 0.961 D 0.768 0.505 0.752617791773 gnomAD-2.1.1 4.03E-06 None None disulfide None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
C/S 5565 Ig-39 23 rs1228967454 0.7128 -2.29 0.961 D 0.768 0.505 0.752617791773 gnomAD-4.0.0 1.59171E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 2.8591E-06 0 0
C/Y 5565 Ig-39 23 None 0.9386 None 0.999 D 0.829 0.491 0.814251235553 gnomAD-4.0.0 1.20032E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/S 5658 Ig-40 22 None 0.1974 None 0.425 N 0.587 0.131 0.146414634003 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
A/V 5658 Ig-40 22 None 0.2592 None 0.023 N 0.384 0.213 0.211220785272 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
A/T 5751 Ig-41 22 rs759726984 0.2045 -1.333 0.505 N 0.726 0.113 0.143124449307 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.92E-06 0
A/T 5751 Ig-41 22 rs759726984 0.2045 -1.333 0.505 N 0.726 0.113 0.143124449307 gnomAD-4.0.0 6.84399E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59846E-06 4.63833E-05 3.31444E-05
C/R 5940 Ig-43 22 rs374882815 0.9981 -1.557 0.879 D 0.875 0.726 None gnomAD-2.1.1 1.4374E-04 None None disulfide None N None 0 0 None 9.71E-05 0 None 0 None 4E-05 2.8477E-04 2.82566E-04
C/R 5940 Ig-43 22 rs374882815 0.9981 -1.557 0.879 D 0.875 0.726 None gnomAD-3.1.2 1.24857E-04 None None disulfide None N None 0 6.55E-05 0 0 0 None 1.88395E-04 0 2.35225E-04 0 0
C/R 5940 Ig-43 22 rs374882815 0.9981 -1.557 0.879 D 0.875 0.726 None gnomAD-4.0.0 1.11564E-04 None None disulfide None N None 0 1.66778E-05 None 3.37998E-05 0 None 7.81397E-05 1.64582E-04 1.43267E-04 2.1965E-05 1.60149E-05
A/G 6033 Ig-44 22 rs771457862 0.2047 -1.92 0.98 N 0.719 0.313 0.187945064343 gnomAD-2.1.1 4.09E-06 None None None None N None 0 0 None 0 5.73E-05 None 0 None 0 0 0
A/G 6033 Ig-44 22 rs771457862 0.2047 -1.92 0.98 N 0.719 0.313 0.187945064343 gnomAD-4.0.0 1.59626E-06 None None None None N None 0 0 None 0 2.79033E-05 None 0 0 0 0 0
A/P 6033 Ig-44 22 None 0.9496 None 0.998 N 0.821 0.307 0.223146558224 gnomAD-4.0.0 6.85132E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16417E-05 0
A/T 6033 Ig-44 22 None 0.1805 None 0.961 N 0.721 0.228 0.188950314367 gnomAD-4.0.0 6.85132E-07 None None None None N None 0 0 None 0 0 None 0 0 9.002E-07 0 0
A/V 6033 Ig-44 22 rs771457862 0.1725 None 0.122 N 0.41 0.25 0.193865811164 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/V 6033 Ig-44 22 rs771457862 0.1725 None 0.122 N 0.41 0.25 0.193865811164 gnomAD-4.0.0 6.57454E-06 None None None None N None 2.41383E-05 0 None 0 0 None 0 0 0 0 0
C/F 6127 Ig-45 23 None 0.7513 None 1.0 D 0.911 0.803 0.901222985285 gnomAD-4.0.0 1.20032E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
C/G 6127 Ig-45 23 rs370812788 0.6188 -2.479 1.0 D 0.895 0.898 None gnomAD-2.1.1 4.68121E-04 None None disulfide None N None 0 0 None 0 6.59454E-03 None 3.27E-05 None 0 7.81E-06 1.40687E-04
C/G 6127 Ig-45 23 rs370812788 0.6188 -2.479 1.0 D 0.895 0.898 None gnomAD-3.1.2 1.31422E-04 None None disulfide None N None 0 0 0 0 3.66937E-03 None 0 0 0 0 4.77555E-04
C/G 6127 Ig-45 23 rs370812788 0.6188 -2.479 1.0 D 0.895 0.898 None 1000 genomes 3.99361E-04 None None disulfide None N None 0 0 None None 2E-03 0 None None None 0 None
C/G 6127 Ig-45 23 rs370812788 0.6188 -2.479 1.0 D 0.895 0.898 None gnomAD-4.0.0 1.21467E-04 None None disulfide None N None 0 0 None 0 3.28228E-03 None 0 0 4.2383E-06 1.09798E-05 6.88441E-04
C/G 6220 Ig-46 22 rs935844203 0.5409 None 0.98 N 0.851 0.587 0.832549399286 gnomAD-4.0.0 6.84301E-07 None None disulfide None N None 0 2.23714E-05 None 0 0 None 0 0 0 0 0
C/R 6220 Ig-46 22 None 0.9881 None 0.997 D 0.885 0.702 0.873414085314 gnomAD-4.0.0 1.3686E-06 None None disulfide None N None 0 0 None 0 2.52029E-05 None 0 1.73671E-04 0 0 0
C/S 6220 Ig-46 22 rs191692293 0.7559 -1.435 0.659 N 0.624 0.563 0.615425489776 gnomAD-2.1.1 5.28881E-04 None None disulfide None N None 5.70531E-03 1.98121E-04 None 0 0 None 3.27E-05 None 0 0 2.81136E-04
C/S 6220 Ig-46 22 rs191692293 0.7559 -1.435 0.659 N 0.624 0.563 0.615425489776 gnomAD-3.1.2 1.72212E-03 None None disulfide None N None 6.17582E-03 3.93082E-04 0 0 0 None 0 0 0 0 0
C/S 6220 Ig-46 22 rs191692293 0.7559 -1.435 0.659 N 0.624 0.563 0.615425489776 1000 genomes 1.99681E-03 None None disulfide None N None 7.6E-03 0 None None 0 0 None None None 0 None
C/S 6220 Ig-46 22 rs191692293 0.7559 -1.435 0.659 N 0.624 0.563 0.615425489776 gnomAD-4.0.0 6.84301E-07 None None disulfide None N None 0 0 None 0 0 None 0 0 8.9957E-07 0 0
C/Y 6220 Ig-46 22 rs191692293 0.8966 None 0.999 D 0.853 0.569 0.770718413961 gnomAD-4.0.0 6.84301E-07 None None disulfide None N None 0 0 None 0 0 None 0 0 8.9958E-07 0 0
S/C 6313 Ig-47 22 None 0.0629 None None N 0.492 0.144 0.0297737177859 gnomAD-4.0.0 1.59802E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44509E-05 0
S/G 6313 Ig-47 22 rs767114791 0.0525 -1.464 None N 0.281 0.058 0.0297737177859 gnomAD-2.1.1 4.12E-06 None None None None N None 0 0 None 0 0 None 3.36E-05 None 0 0 0
S/G 6313 Ig-47 22 rs767114791 0.0525 -1.464 None N 0.281 0.058 0.0297737177859 gnomAD-4.0.0 1.59802E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.03472E-05
S/T 6313 Ig-47 22 rs200120672 0.1185 -0.521 0.024 N 0.587 0.166 None gnomAD-2.1.1 9.39959E-04 None None None None N None 0 0 None 0 0 None 0 None 9.1488E-03 1.84165E-04 1.1458E-03
S/T 6313 Ig-47 22 rs200120672 0.1185 -0.521 0.024 N 0.587 0.166 None gnomAD-3.1.2 9.07095E-04 None None None None N None 0 0 0 0 0 None 1.14921E-02 0 2.0587E-04 0 9.5511E-04
S/T 6313 Ig-47 22 rs200120672 0.1185 -0.521 0.024 N 0.587 0.166 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
S/T 6313 Ig-47 22 rs200120672 0.1185 -0.521 0.024 N 0.587 0.166 None gnomAD-4.0.0 3.58723E-04 None None None None N None 0 0 None 0 0 None 8.16154E-03 0 3.30859E-05 0 2.88554E-04
C/Y 6406 Ig-48 22 None 0.7792 None 1.0 D 0.943 0.58 0.807043397782 gnomAD-4.0.0 1.59331E-06 None None None None N None 0 0 None 0 2.77608E-05 None 0 0 0 0 0
C/Y 6502 Ig-49 22 None 0.8535 None 1.0 D 0.923 0.624 0.81509260357 gnomAD-4.0.0 1.59346E-06 None None disulfide None N None 0 0 None 0 0 None 0 2.41663E-04 0 0 0
A/T 6595 Ig-50 22 rs1305423472 0.112 -1.364 0.811 N 0.702 0.254 0.273503213844 gnomAD-2.1.1 7.16E-06 None None None None N None 0 0 None 0 5.13E-05 None 0 None 4.01E-05 0 0
A/T 6595 Ig-50 22 rs1305423472 0.112 -1.364 0.811 N 0.702 0.254 0.273503213844 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.43E-05 0 0 0 0
A/T 6595 Ig-50 22 rs1305423472 0.112 -1.364 0.811 N 0.702 0.254 0.273503213844 gnomAD-4.0.0 2.48042E-06 None None None None N None 0 0 None 0 4.45891E-05 None 1.56284E-05 0 8.48043E-07 0 0
C/R 6782 Ig-52 22 rs748769034 0.9856 -1.335 1.0 D 0.898 0.848 0.938715776434 gnomAD-4.0.0 6.86143E-07 None None disulfide None N None 0 0 None 0 2.52972E-05 None 0 0 0 0 0
C/Y 6782 Ig-52 22 rs1193444668 0.8911 -1.688 1.0 D 0.897 0.663 0.915343352074 gnomAD-2.1.1 4.06E-06 None None disulfide None N None 6.52E-05 0 None 0 0 None 0 None 0 0 0
C/Y 6782 Ig-52 22 rs1193444668 0.8911 -1.688 1.0 D 0.897 0.663 0.915343352074 gnomAD-3.1.2 6.57E-06 None None disulfide None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
C/Y 6782 Ig-52 22 rs1193444668 0.8911 -1.688 1.0 D 0.897 0.663 0.915343352074 gnomAD-4.0.0 2.57643E-06 None None disulfide None N None 3.39075E-05 0 None 0 0 None 0 0 0 0 0
A/T 6875 Ig-53 22 rs756292622 0.1416 -1.468 0.576 N 0.449 0.248 0.110078149338 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
A/T 6875 Ig-53 22 rs756292622 0.1416 -1.468 0.576 N 0.449 0.248 0.110078149338 gnomAD-4.0.0 2.05493E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80018E-06 1.16452E-05 0
A/V 6875 Ig-53 22 rs199875225 0.1635 None 0.978 N 0.696 0.277 0.227934060464 gnomAD-4.0.0 1.59542E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86438E-06 0 0
C/R 6969 Ig-54 22 rs368762020 0.994 -0.641 0.966 D 0.853 0.47 0.842632066669 gnomAD-2.1.1 4.43E-05 None None None None N None 0 0 None 0 0 None 3.59971E-04 None 0 0 0
C/R 6969 Ig-54 22 rs368762020 0.994 -0.641 0.966 D 0.853 0.47 0.842632066669 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 0 4.158E-04 0
C/R 6969 Ig-54 22 rs368762020 0.994 -0.641 0.966 D 0.853 0.47 0.842632066669 gnomAD-4.0.0 1.36424E-05 None None None None N None 0 0 None 0 0 None 0 0 0 2.4179E-04 0
C/S 6969 Ig-54 22 rs368762020 0.89 -1.638 0.454 D 0.701 0.424 0.613482770441 gnomAD-2.1.1 4.03E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
C/S 6969 Ig-54 22 rs368762020 0.89 -1.638 0.454 D 0.701 0.424 0.613482770441 gnomAD-4.0.0 3.72039E-06 None None None None N None 8.01196E-05 0 None 0 0 None 0 0 0 0 0
S/G 7158 Ig-56 22 None 0.1427 None 0.001 N 0.298 0.208 0.0806252709748 gnomAD-4.0.0 3.19292E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86467E-06 1.44288E-05 0
S/N 7158 Ig-56 22 rs1325004608 0.7508 -0.92 0.642 N 0.626 0.217 0.12205267543 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
S/N 7158 Ig-56 22 rs1325004608 0.7508 -0.92 0.642 N 0.626 0.217 0.12205267543 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/N 7158 Ig-56 22 rs1325004608 0.7508 -0.92 0.642 N 0.626 0.217 0.12205267543 gnomAD-4.0.0 6.57358E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47042E-05 0 0
S/R 7158 Ig-56 22 rs1229825752 0.9903 -0.461 0.97 N 0.774 0.253 0.227934060464 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 3.35E-05 None 0 0 0
S/R 7158 Ig-56 22 rs1229825752 0.9903 -0.461 0.97 N 0.774 0.253 0.227934060464 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/R 7158 Ig-56 22 rs1229825752 0.9903 -0.461 0.97 N 0.774 0.253 0.227934060464 gnomAD-4.0.0 6.85415E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.16874E-05 0
S/T 7158 Ig-56 22 rs1325004608 0.1466 None 0.425 N 0.56 0.159 0.107399877778 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/T 7158 Ig-56 22 rs1325004608 0.1466 None 0.425 N 0.56 0.159 0.107399877778 gnomAD-4.0.0 3.04496E-06 None None None None N None 0 0 None 0 0 None 0 0 3.61484E-06 0 0
S/I 7251 Ig-57 22 rs1387731794 0.3147 0.872 0.106 N 0.791 0.125 0.241078983079 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 9.98E-05 0 None 0 None 0 0 0
S/I 7251 Ig-57 22 rs1387731794 0.3147 0.872 0.106 N 0.791 0.125 0.241078983079 gnomAD-4.0.0 1.59182E-06 None None None None N None 0 0 None 4.76917E-05 0 None 0 0 0 0 0
C/F 7440 Ig-59 22 rs2154302041 0.8392 None 1.0 D 0.913 0.806 0.9316426571 gnomAD-4.0.0 1.20032E-06 None None disulfide None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
C/Y 7440 Ig-59 22 None 0.9678 None 1.0 D 0.927 0.801 0.918509175114 gnomAD-4.0.0 1.20032E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
C/R 7630 Ig-61 23 rs1553908536 0.9972 None 1.0 D 0.925 0.688 0.892145347143 gnomAD-4.0.0 1.36928E-06 None None disulfide None N None 0 2.23704E-05 None 0 0 None 0 0 9.00043E-07 0 0
C/S 7630 Ig-61 23 rs781175517 0.9172 -2.436 1.0 D 0.831 0.703 0.729621422929 gnomAD-2.1.1 4.03E-05 None None disulfide None N None 0 0 None 0 0 None 0 None 0 8.9E-05 0
C/S 7630 Ig-61 23 rs781175517 0.9172 -2.436 1.0 D 0.831 0.703 0.729621422929 gnomAD-4.0.0 6.84518E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 8.9987E-06 0 0
C/Y 7630 Ig-61 23 None 0.9779 None 1.0 D 0.921 0.541 0.786383566872 gnomAD-4.0.0 6.84518E-07 None None disulfide None N None 0 0 None 0 0 None 0 0 8.9987E-07 0 0
C/R 7723 Ig-62 22 rs2078198396 0.9968 None 1.0 D 0.899 0.764 0.879085847899 gnomAD-4.0.0 1.36887E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 0 1.16001E-05 1.65761E-05
C/Y 7723 Ig-62 22 None 0.983 None 1.0 D 0.881 0.606 0.810734245384 gnomAD-4.0.0 1.20032E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/V 7816 Ig-63 22 None 0.3075 None 0.997 N 0.719 0.253 0.215109475489 gnomAD-4.0.0 1.5915E-06 None None None None N None 0 0 None 0 2.77331E-05 None 0 0 0 0 0
C/F 7910 Ig-64 22 rs763596594 0.7296 None 0.997 D 0.877 0.484 0.848056490861 gnomAD-4.0.0 1.36858E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31906E-05 0
C/G 7910 Ig-64 22 None 0.6123 None 0.999 D 0.879 0.494 0.866244543547 gnomAD-4.0.0 6.84298E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99564E-07 0 0
C/R 7910 Ig-64 22 rs1577982173 0.9905 None 0.999 D 0.909 0.501 0.867620490056 gnomAD-4.0.0 4.10579E-06 None None None None N None 0 0 None 0 1.51164E-04 None 0 0 0 0 0
C/Y 7910 Ig-64 22 rs763596594 0.8929 -1.363 0.999 D 0.88 0.485 0.805304863586 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
C/Y 7910 Ig-64 22 rs763596594 0.8929 -1.363 0.999 D 0.88 0.485 0.805304863586 gnomAD-4.0.0 6.8429E-07 None None None None N None 0 2.23624E-05 None 0 0 None 0 0 0 0 0
C/Y 8006 Ig-65 22 rs764282358 0.9456 -1.784 1.0 D 0.92 0.613 0.795667397281 gnomAD-2.1.1 4.02E-06 None None disulfide None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
C/Y 8006 Ig-65 22 rs764282358 0.9456 -1.784 1.0 D 0.92 0.613 0.795667397281 gnomAD-4.0.0 8.89474E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 1.16933E-05 0 0
S/G 8099 Ig-66 22 None 0.1612 None None N 0.297 0.184 0.0297737177859 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
S/N 8099 Ig-66 22 rs1194437921 0.7544 -0.815 0.117 N 0.652 0.212 0.101711395817 gnomAD-4.0.0 1.36881E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99612E-07 1.16028E-05 0
S/R 8099 Ig-66 22 rs1289470566 0.9922 -0.408 0.484 N 0.784 0.308 0.126345400529 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 2.87687E-04 0 0
S/R 8099 Ig-66 22 rs1289470566 0.9922 -0.408 0.484 N 0.784 0.308 0.126345400529 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.42E-05 0 0 0 0
S/R 8099 Ig-66 22 rs1289470566 0.9922 -0.408 0.484 N 0.784 0.308 0.126345400529 gnomAD-4.0.0 2.56374E-06 None None None None N None 0 0 None 0 0 None 3.14001E-05 0 0 0 0
A/S 8192 Ig-67 22 rs2077844059 0.153 None 0.001 N 0.339 0.045 0.107399877778 gnomAD-4.0.0 1.5915E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85858E-06 0 0
C/G 8285 Ig-68 22 rs757040162 0.6744 -2.511 1.0 D 0.897 0.82 0.933987002762 gnomAD-2.1.1 4.1E-06 None None disulfide None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
C/R 8285 Ig-68 22 None 0.9938 None 1.0 D 0.927 0.84 0.928824428499 gnomAD-4.0.0 6.87163E-07 None None disulfide None N None 0 0 None 0 0 None 0 0 8.99601E-07 0 0
C/S 8285 Ig-68 22 rs757040162 0.9243 -2.348 1.0 D 0.83 0.839 0.882702632475 gnomAD-2.1.1 4.1E-06 None None disulfide None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
C/S 8285 Ig-68 22 rs757040162 0.9243 -2.348 1.0 D 0.83 0.839 0.882702632475 gnomAD-4.0.0 1.37433E-06 None None disulfide None N None 0 0 None 0 5.03956E-05 None 0 0 0 0 0
T/A 8757 Ig-73 22 None 0.0496 None None N 0.3 0.116 0.0138822411134 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
T/I 8757 Ig-73 22 rs1357129552 0.2624 None 0.117 N 0.679 0.266 0.171388866994 gnomAD-4.0.0 6.84407E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99628E-07 0 0
T/N 8757 Ig-73 22 None 0.2681 None 0.211 N 0.683 0.263 0.167679373172 gnomAD-4.0.0 6.84407E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15988E-05 0
T/S 8757 Ig-73 22 None 0.1141 None 0.027 N 0.517 0.08 0.0716867268079 gnomAD-4.0.0 6.84407E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99628E-07 0 0
C/G 8851 Ig-74 22 rs558169834 0.4112 -2.459 0.999 D 0.861 0.563 None gnomAD-2.1.1 3.22E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 6.21E-05 0
C/G 8851 Ig-74 22 rs558169834 0.4112 -2.459 0.999 D 0.861 0.563 None gnomAD-3.1.2 2.63E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 4.41E-05 0 0
C/G 8851 Ig-74 22 rs558169834 0.4112 -2.459 0.999 D 0.861 0.563 None gnomAD-4.0.0 7.12768E-05 None None None None N None 1.33593E-05 0 None 0 0 None 0 0 9.49397E-05 0 3.20277E-05
C/Y 8851 Ig-74 22 rs398124444 0.6285 -1.671 0.999 D 0.858 0.554 0.796275195805 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
C/Y 8851 Ig-74 22 rs398124444 0.6285 -1.671 0.999 D 0.858 0.554 0.796275195805 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
C/Y 8851 Ig-74 22 rs398124444 0.6285 -1.671 0.999 D 0.858 0.554 0.796275195805 gnomAD-4.0.0 4.95785E-06 None None None None N None 1.33526E-05 0 None 0 0 None 0 0 5.93343E-06 0 0
C/R 8947 Ig-75 22 None 0.9958 None 1.0 D 0.937 0.721 0.845864305578 gnomAD-4.0.0 6.90009E-07 None None disulfide None N None 0 0 None 0 0 None 0 0 9.04863E-07 0 0
C/S 8947 Ig-75 22 rs757162312 0.9279 -2.556 1.0 D 0.842 0.696 0.769641750319 gnomAD-2.1.1 4.42E-06 None None disulfide None N None 0 0 None 0 0 None 3.58E-05 None 0 0 0
C/S 8947 Ig-75 22 rs757162312 0.9279 -2.556 1.0 D 0.842 0.696 0.769641750319 gnomAD-4.0.0 6.90009E-07 None None disulfide None N None 0 0 None 0 0 None 0 0 0 1.18717E-05 0
C/Y 8947 Ig-75 22 rs562939601 0.9702 -1.861 1.0 D 0.937 0.595 0.795285701735 gnomAD-3.1.2 1.31E-05 None None disulfide None N None 2.42E-05 0 0 0 1.92901E-04 None 0 0 0 0 0
C/Y 8947 Ig-75 22 rs562939601 0.9702 -1.861 1.0 D 0.937 0.595 0.795285701735 1000 genomes 1.99681E-04 None None disulfide None N None 0 0 None None 1E-03 0 None None None 0 None
C/Y 8947 Ig-75 22 rs562939601 0.9702 -1.861 1.0 D 0.937 0.595 0.795285701735 gnomAD-4.0.0 7.80709E-06 None None disulfide None N None 1.69199E-05 0 None 0 2.44882E-05 None 0 0 7.2937E-06 0 2.87274E-05
S/G 9040 Ig-76 22 rs751149532 0.1465 -1.346 0.27 N 0.605 0.183 0.146414634003 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
S/G 9040 Ig-76 22 rs751149532 0.1465 -1.346 0.27 N 0.605 0.183 0.146414634003 gnomAD-4.0.0 1.5926E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02608E-05
G/A 9133 Ig-77 22 None 0.0766 None 0.022 N 0.305 0.192 0.132336055621 gnomAD-4.0.0 6.84281E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99517E-07 0 0
G/D 9133 Ig-77 22 None 0.835 None 0.966 N 0.763 0.265 0.273938319068 gnomAD-4.0.0 6.84282E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99518E-07 0 0
G/S 9133 Ig-77 22 None 0.1009 None 0.669 N 0.643 0.134 0.177238962908 gnomAD-4.0.0 8.89577E-06 None None None None N None 0 0 None 0 0 None 0 0 1.16937E-05 0 0
G/V 9133 Ig-77 22 rs773438838 0.1619 0.471 0.051 N 0.594 0.23 None gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
G/V 9133 Ig-77 22 rs773438838 0.1619 0.471 0.051 N 0.594 0.23 None gnomAD-4.0.0 1.36856E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31911E-05 0
C/R 9226 Ig-78 22 rs372820178 0.9946 -1.502 1.0 D 0.919 0.693 None gnomAD-2.1.1 2.86E-05 None None disulfide None N None 8.3E-05 0 None 0 0 None 0 None 0 3.91E-05 1.4041E-04
C/R 9226 Ig-78 22 rs372820178 0.9946 -1.502 1.0 D 0.919 0.693 None gnomAD-3.1.2 3.29E-05 None None disulfide None N None 0 0 0 0 0 None 0 0 7.35E-05 0 0
C/R 9226 Ig-78 22 rs372820178 0.9946 -1.502 1.0 D 0.919 0.693 None 1000 genomes 1.99681E-04 None None disulfide None N None 0 0 None None 0 1E-03 None None None 0 None
C/R 9226 Ig-78 22 rs372820178 0.9946 -1.502 1.0 D 0.919 0.693 None gnomAD-4.0.0 1.23311E-04 None None disulfide None N None 3.99861E-05 0 None 0 0 None 3.12412E-05 0 1.61895E-04 0 4.80123E-05
C/Y 9226 Ig-78 22 rs369108107 0.9283 -1.557 1.0 D 0.915 0.585 None gnomAD-2.1.1 8.05E-06 None None disulfide None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
C/Y 9226 Ig-78 22 rs369108107 0.9283 -1.557 1.0 D 0.915 0.585 None gnomAD-3.1.2 6.57E-06 None None disulfide None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
C/Y 9226 Ig-78 22 rs369108107 0.9283 -1.557 1.0 D 0.915 0.585 None gnomAD-4.0.0 9.29559E-06 None None disulfide None N None 5.33988E-05 0 None 0 0 None 0 4.93259E-04 3.39048E-06 0 6.40471E-05
C/S 9322 Ig-79 22 None 0.7471 None 1.0 None 0.827 0.701 0.725725988762 gnomAD-4.0.0 1.592E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 2.85889E-06 0 0
C/R 9418 Ig-80 22 rs770276972 0.9924 -1.807 1.0 None 0.935 0.695 0.869964133223 gnomAD-2.1.1 4.02E-06 None None disulfide None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
C/R 9418 Ig-80 22 rs770276972 0.9924 -1.807 1.0 None 0.935 0.695 0.869964133223 gnomAD-4.0.0 7.95532E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 1.42897E-05 0 0
A/T 9719 Ig-83 22 rs2075926309 0.7596 None 0.884 None 0.471 0.301 0.244539031024 gnomAD-4.0.0 2.05944E-06 None None None None N None 3.00463E-05 0 None 0 0 None 0 0 1.8043E-06 0 0
I/T 9921 Ig-84 22 rs373651676 0.5917 -3.671 0.425 None 0.656 0.17 None gnomAD-2.1.1 3.97E-05 None None None None N None 0 0 None 0 0 None 3.29E-05 None 0 7.88E-05 0
I/T 9921 Ig-84 22 rs373651676 0.5917 -3.671 0.425 None 0.656 0.17 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/T 9921 Ig-84 22 rs373651676 0.5917 -3.671 0.425 None 0.656 0.17 None gnomAD-4.0.0 4.34417E-05 None None None None N None 0 0 None 6.7627E-05 0 None 0 0 5.51147E-05 1.09946E-05 3.20554E-05
C/G 10010 Ig-85 22 None 0.8899 None 1.0 None 0.91 0.701 0.856695912731 gnomAD-4.0.0 1.59085E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 2.85747E-06 0 0
C/R 10099 Ig-86 22 rs2075201214 0.9995 None 1.0 None 0.867 0.6 0.622959606287 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
C/S 10099 Ig-86 22 None 0.9925 None 1.0 None 0.74 0.541 0.500742145641 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
C/W 13708 Ig-87 25 rs794729424 0.9986 None 0.999 D 0.877 0.444 0.73502437085 gnomAD-4.0.0 1.3687E-06 None None disulfide None N None 0 0 None 3.8279E-05 0 None 0 0 0 0 1.65728E-05
C/Y 13708 Ig-87 25 None 0.9942 None 0.995 D 0.875 0.495 0.77324528785 gnomAD-4.0.0 1.59205E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 0 0 3.02645E-05
C/Y 13802 Ig-88 23 None 0.9853 None 0.998 D 0.813 0.414 0.431035450679 gnomAD-4.0.0 1.59385E-06 None None None None N None 0 0 None 0 2.79236E-05 None 0 0 0 0 0
A/G 13986 Ig-90 22 None 0.556 None 0.361 N 0.655 0.138 0.101711395817 gnomAD-4.0.0 1.59234E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43324E-05 0
A/T 13986 Ig-90 22 rs1208784748 0.3443 None 0.001 N 0.249 0.198 0.0611884634855 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
C/F 14075 Ig-91 22 None 0.8565 None 1.0 D 0.881 0.582 0.846589922519 gnomAD-4.0.0 1.59215E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43312E-05 0
C/G 14163 Ig-92 22 rs1310975229 0.6869 -2.674 0.784 D 0.733 0.414 0.831548404372 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
C/G 14163 Ig-92 22 rs1310975229 0.6869 -2.674 0.784 D 0.733 0.414 0.831548404372 gnomAD-4.0.0 1.59216E-06 None None None None N None 0 0 None 0 2.77531E-05 None 0 0 0 0 0
C/G 14252 Ig-93 22 rs1372237054 0.575 -2.542 0.97 D 0.859 0.571 0.699194967022 gnomAD-2.1.1 4.04E-06 None None disulfide None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
C/G 14252 Ig-93 22 rs1372237054 0.575 -2.542 0.97 D 0.859 0.571 0.699194967022 gnomAD-3.1.2 1.31E-05 None None disulfide None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
C/G 14252 Ig-93 22 rs1372237054 0.575 -2.542 0.97 D 0.859 0.571 0.699194967022 gnomAD-4.0.0 5.57904E-06 None None disulfide None N None 1.06812E-04 0 None 0 0 None 0 0 8.47746E-07 0 0
I/T 14340 Ig-94 22 rs397517571 0.381 -3.424 0.682 N 0.837 0.354 0.333651784274 gnomAD-2.1.1 1.21E-05 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 8.9E-06 1.66389E-04
I/T 14340 Ig-94 22 rs397517571 0.381 -3.424 0.682 N 0.837 0.354 0.333651784274 gnomAD-3.1.2 4.6E-05 None None None None N None 0 3.92979E-04 0 2.88351E-04 0 None 0 0 0 0 0
I/T 14340 Ig-94 22 rs397517571 0.381 -3.424 0.682 N 0.837 0.354 0.333651784274 gnomAD-4.0.0 1.36363E-05 None None None None N None 2.66681E-05 1.0001E-04 None 3.37998E-05 0 None 0 0 5.08681E-06 0 1.12086E-04
C/Y 14429 Ig-95 22 rs2059953559 0.9317 None 0.999 D 0.882 0.568 0.903517915455 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
C/Y 14429 Ig-95 22 rs2059953559 0.9317 None 0.999 D 0.882 0.568 0.903517915455 gnomAD-4.0.0 6.57056E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07383E-04 0
V/M 14518 Ig-96 22 rs746989081 0.4518 -0.697 0.896 D 0.653 0.488 0.735016723692 gnomAD-2.1.1 1.28E-05 None None None None N None 0 0 None 0 1.1966E-04 None 0 None 0 9.52E-06 0
V/M 14518 Ig-96 22 rs746989081 0.4518 -0.697 0.896 D 0.653 0.488 0.735016723692 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94099E-04 None 0 0 0 0 0
V/M 14518 Ig-96 22 rs746989081 0.4518 -0.697 0.896 D 0.653 0.488 0.735016723692 gnomAD-4.0.0 4.36051E-06 None None None None N None 0 0 None 0 6.76072E-05 None 0 1.64908E-04 2.55186E-06 0 0
C/R 14607 Ig-97 22 None 0.9886 None 1.0 D 0.881 0.745 0.874117924916 gnomAD-4.0.0 1.20032E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
C/Y 14607 Ig-97 22 rs781427869 0.9621 -1.669 1.0 D 0.876 0.685 0.811788188336 gnomAD-2.1.1 1.21E-05 None None disulfide None N None 0 8.72E-05 None 0 0 None 0 None 0 0 0
C/Y 14607 Ig-97 22 rs781427869 0.9621 -1.669 1.0 D 0.876 0.685 0.811788188336 gnomAD-3.1.2 6.58E-06 None None disulfide None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
C/Y 14607 Ig-97 22 rs781427869 0.9621 -1.669 1.0 D 0.876 0.685 0.811788188336 gnomAD-4.0.0 5.58056E-06 None None disulfide None N None 0 6.67512E-05 None 0 0 None 0 0 8.47825E-07 0 6.40985E-05
C/F 14785 Ig-99 21 rs757662563 0.8264 -1.255 1.0 D 0.872 0.643 0.843457257234 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.68881E-04 None 0 None 0 0 0
C/F 14785 Ig-99 21 rs757662563 0.8264 -1.255 1.0 D 0.872 0.643 0.843457257234 gnomAD-4.0.0 3.18631E-06 None None None None N None 0 0 None 0 5.57289E-05 None 0 0 0 0 0
C/Y 14874 Ig-100 22 rs375446773 0.9886 -1.685 1.0 D 0.903 0.616 None gnomAD-4.0.0 1.20034E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
C/G 14963 Ig-101 22 rs763137894 0.6636 -2.552 1.0 D 0.863 0.743 0.879665004704 gnomAD-2.1.1 3.19E-05 None None disulfide None N None 0 0 None 0 0 None 0 None 2.87853E-04 0 0
C/G 14963 Ig-101 22 rs763137894 0.6636 -2.552 1.0 D 0.863 0.743 0.879665004704 gnomAD-3.1.2 6.59E-06 None None disulfide None N None 0 0 0 0 0 None 9.44E-05 0 0 0 0
C/G 14963 Ig-101 22 rs763137894 0.6636 -2.552 1.0 D 0.863 0.743 0.879665004704 gnomAD-4.0.0 9.04418E-06 None None disulfide None N None 0 0 None 0 0 None 9.46014E-05 0 2.41031E-06 0 0
C/Y 15052 Ig-102 22 rs2058300029 0.9834 None 1.0 D 0.924 0.779 0.924196854224 gnomAD-4.0.0 2.05432E-06 None None disulfide None N None 2.99473E-05 0 None 0 0 None 0 0 1.79989E-06 0 0
C/Y 15229 Ig-104 22 rs753818213 0.949 -1.44 0.983 D 0.849 0.579 0.778977725916 gnomAD-2.1.1 8.09E-06 None None None None N None 0 5.83E-05 None 0 0 None 0 None 0 0 0
C/Y 15229 Ig-104 22 rs753818213 0.949 -1.44 0.983 D 0.849 0.579 0.778977725916 gnomAD-4.0.0 3.18814E-06 None None None None N None 0 4.58568E-05 None 0 0 None 0 0 0 0 0
A/T 15501 Ig-107 22 None 0.4405 None 0.992 D 0.669 0.585 0.594113984522 gnomAD-4.0.0 1.59457E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86454E-06 0 0
A/V 15501 Ig-107 22 None 0.3037 None 0.619 N 0.413 0.392 0.526995340713 gnomAD-4.0.0 1.59458E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86456E-06 0 0
V/A 15589 Ig-108 22 rs760270288 0.4824 -1.946 0.998 N 0.721 0.331 0.519351293798 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
V/A 15589 Ig-108 22 rs760270288 0.4824 -1.946 0.998 N 0.721 0.331 0.519351293798 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
V/L 15589 Ig-108 22 rs2057787860 0.2411 None 0.981 N 0.692 0.257 0.448000600372 gnomAD-4.0.0 3.19332E-06 None None None None N None 0 0 None 0 0 None 0 0 5.73161E-06 0 0
V/L 15984 Ig-109 17 rs766367585 0.5479 0.308 0.997 D 0.698 0.335 0.534046140783 gnomAD-2.1.1 2.02E-05 None None None None N None 0 0 None 0 0 None 1.63409E-04 None 0 0 0
V/L 15984 Ig-109 17 rs766367585 0.5479 0.308 0.997 D 0.698 0.335 0.534046140783 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 0 2.07125E-04 4.79386E-04
V/L 15984 Ig-109 17 rs766367585 0.5479 0.308 0.997 D 0.698 0.335 0.534046140783 gnomAD-4.0.0 1.15473E-05 None None None None N None 0 1.69745E-05 None 0 0 None 0 0 0 9.38313E-05 2.84965E-05
A/T 16280 Ig-110 19 rs372911542 0.8322 -1.589 1.0 D 0.859 0.334 None gnomAD-2.1.1 4.85E-05 None None None None N None 0 2.03844E-04 None 0 0 None 0 None 0 3.58E-05 1.67001E-04
A/T 16280 Ig-110 19 rs372911542 0.8322 -1.589 1.0 D 0.859 0.334 None gnomAD-3.1.2 5.93E-05 None None None None N None 2.42E-05 4.59982E-04 0 0 0 None 0 0 1.47E-05 0 0
A/T 16280 Ig-110 19 rs372911542 0.8322 -1.589 1.0 D 0.859 0.334 None gnomAD-4.0.0 3.53571E-05 None None None None N None 1.3369E-05 2.33996E-04 None 0 2.24427E-05 None 0 3.29598E-04 2.96844E-05 0 6.41416E-05
A/P 17269 Ig-112 19 rs778693629 0.9817 None 1.0 N 0.883 0.413 None gnomAD-4.0.0 3.42358E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59976E-06 0 1.65859E-05
A/S 17269 Ig-112 19 rs778693629 0.3983 -1.797 1.0 N 0.656 0.217 None gnomAD-2.1.1 1.79E-05 None None None None N None 0 2.83E-05 None 0 0 None 0 None 0 1.57E-05 2.81928E-04
A/S 17269 Ig-112 19 rs778693629 0.3983 -1.797 1.0 N 0.656 0.217 None gnomAD-3.1.2 5.27E-05 None None None None N None 2.42E-05 3.28213E-04 0 0 0 None 0 0 0 0 9.56023E-04
A/S 17269 Ig-112 19 rs778693629 0.3983 -1.797 1.0 N 0.656 0.217 None gnomAD-4.0.0 1.05434E-05 None None None None N None 2.6738E-05 1.16834E-04 None 0 0 None 0 0 8.48089E-07 0 1.12208E-04
A/T 17269 Ig-112 19 None 0.5345 None 1.0 N 0.847 0.342 0.319402600006 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 17269 Ig-112 19 None 0.5345 None 1.0 N 0.847 0.342 0.319402600006 gnomAD-4.0.0 1.2404E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69618E-06 0 0
A/T 17694 Ig-113 18 None 0.5786 None 0.999 N 0.831 0.354 0.338834610459 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
A/T 18400 Ig-115 19 rs769472573 0.4188 -1.151 1.0 N 0.808 0.388 0.194818534648 gnomAD-2.1.1 3.22E-05 None None None None N None 0 0 None 0 0 None 2.61558E-04 None 0 0 0
A/T 18400 Ig-115 19 rs769472573 0.4188 -1.151 1.0 N 0.808 0.388 0.194818534648 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 0 4.14594E-04 0
A/T 18400 Ig-115 19 rs769472573 0.4188 -1.151 1.0 N 0.808 0.388 0.194818534648 gnomAD-4.0.0 1.9842E-05 None None None None N None 0 0 None 0 0 None 0 0 0 3.51571E-04 0
A/V 18400 Ig-115 19 None 0.2979 None 1.0 N 0.736 0.384 0.283761946502 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
A/T 19114 Ig-117 20 rs2052103828 0.3799 None 1.0 N 0.847 0.429 0.385417323374 gnomAD-4.0.0 2.40065E-06 None None None None N None 1.26695E-04 0 None 0 0 None 0 0 0 0 0
A/V 19808 Ig-119 19 rs780766254 0.5562 1.05 1.0 N 0.777 0.437 0.315314060047 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 1.11794E-04 None 0 None 0 0 0
A/V 19808 Ig-119 19 rs780766254 0.5562 1.05 1.0 N 0.777 0.437 0.315314060047 gnomAD-4.0.0 4.106E-06 None None None None N None 0 0 None 0 2.52347E-05 None 0 0 3.59836E-06 0 1.65673E-05
A/T 20100 Ig-120 21 rs748929812 0.4865 -0.554 1.0 N 0.872 0.432 0.336155897331 gnomAD-2.1.1 3.31E-05 None None None None N None 0 0 None 0 0 None 2.10069E-04 None 0 1.82E-05 0
A/T 20100 Ig-120 21 rs748929812 0.4865 -0.554 1.0 N 0.872 0.432 0.336155897331 gnomAD-4.0.0 1.85614E-05 None None None None N None 0 0 None 0 0 None 0 5.23743E-04 9.01884E-06 9.43908E-05 9.98768E-05
A/V 20100 Ig-120 21 rs1388164549 0.3738 1.128 1.0 N 0.757 0.425 0.305410167561 gnomAD-2.1.1 4.14E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.08E-06 0
A/V 20100 Ig-120 21 rs1388164549 0.3738 1.128 1.0 N 0.757 0.425 0.305410167561 gnomAD-4.0.0 4.82417E-06 None None None None N None 0 0 None 0 0 None 0 0 8.64469E-06 0 0
A/V 20498 Ig-121 20 rs145131899 0.6305 0.567 0.946 N 0.719 0.224 None gnomAD-2.1.1 1.74E-05 None None None None N None 0 9.26E-05 None 0 0 None 0 None 0 9.47E-06 0
A/V 20498 Ig-121 20 rs145131899 0.6305 0.567 0.946 N 0.719 0.224 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
A/V 20498 Ig-121 20 rs145131899 0.6305 0.567 0.946 N 0.719 0.224 None 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
A/V 20498 Ig-121 20 rs145131899 0.6305 0.567 0.946 N 0.719 0.224 None gnomAD-4.0.0 3.94527E-06 None None None None N None 0 3.5025E-05 None 0 0 None 0 0 2.45102E-06 0 0
A/G 21196 Ig-123 20 rs1460483373 0.1514 None 1.0 N 0.708 0.351 0.335164054921 gnomAD-4.0.0 1.59346E-06 None None None None N None 0 0 None 0 2.78707E-05 None 0 0 0 0 0
A/D 21488 Ig-124 20 None 0.9949 None 1.0 N 0.903 0.459 0.56713362702 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
A/S 21488 Ig-124 20 rs374992146 0.3515 -1.711 1.0 N 0.712 0.413 0.374255764437 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.665E-04
A/S 21488 Ig-124 20 rs374992146 0.3515 -1.711 1.0 N 0.712 0.413 0.374255764437 gnomAD-4.0.0 1.59512E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86403E-06 0 0
A/T 21488 Ig-124 20 rs374992146 0.5384 -1.48 1.0 N 0.871 0.387 0.381071309025 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.3E-05 None 0 0 0
A/T 21488 Ig-124 20 rs374992146 0.5384 -1.48 1.0 N 0.871 0.387 0.381071309025 gnomAD-4.0.0 1.59512E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43951E-05 0
A/P 21885 Ig-125 20 rs766178095 0.9942 -0.443 1.0 N 0.872 0.43 0.448399296293 gnomAD-2.1.1 7.19E-06 None None None None N None 8.29E-05 0 None 0 0 None 0 None 0 0 0
A/P 21885 Ig-125 20 rs766178095 0.9942 -0.443 1.0 N 0.872 0.43 0.448399296293 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
A/P 21885 Ig-125 20 rs766178095 0.9942 -0.443 1.0 N 0.872 0.43 0.448399296293 gnomAD-4.0.0 1.3153E-05 None None None None N None 4.82719E-05 0 None 0 0 None 0 0 0 0 0
V/A 22283 Ig-126 19 rs1246688280 0.7939 -1.719 0.025 N 0.421 0.121 0.439551795455 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.94E-06 0
V/A 22283 Ig-126 19 rs1246688280 0.7939 -1.719 0.025 N 0.421 0.121 0.439551795455 gnomAD-4.0.0 1.59361E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86185E-06 0 0
V/I 22283 Ig-126 19 rs554828165 0.1169 0.03 0.773 N 0.621 0.195 0.543734688498 gnomAD-2.1.1 2.83E-05 None None None None I None 0 0 None 0 0 None 2.29028E-04 None 0 0 0
V/I 22283 Ig-126 19 rs554828165 0.1169 0.03 0.773 N 0.621 0.195 0.543734688498 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 0 4.13736E-04 0
V/I 22283 Ig-126 19 rs554828165 0.1169 0.03 0.773 N 0.621 0.195 0.543734688498 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
V/I 22283 Ig-126 19 rs554828165 0.1169 0.03 0.773 N 0.621 0.195 0.543734688498 gnomAD-4.0.0 1.4261E-05 None None None None I None 0 0 None 0 0 None 0 0 0 2.19688E-04 4.80677E-05
I/F 22572 Ig-127 13 rs779301386 0.4106 -1.444 0.217 N 0.471 0.26 0.355658859761 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
I/F 22572 Ig-127 13 rs779301386 0.4106 -1.444 0.217 N 0.471 0.26 0.355658859761 gnomAD-4.0.0 1.60123E-06 None None None None I None 0 0 None 0 0 None 0 0 2.87743E-06 0 0
I/F 22969 Ig-128 20 rs771013967 0.1422 None 0.966 D 0.724 0.238 0.550128394979 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.9425E-04 None 0 0 0 0 0
I/F 22969 Ig-128 20 rs771013967 0.1422 None 0.966 D 0.724 0.238 0.550128394979 gnomAD-4.0.0 1.8626E-06 None None None None N None 0 0 None 0 6.71532E-05 None 0 0 0 0 0
I/V 22969 Ig-128 20 rs771013967 0.0676 None 0.267 N 0.469 0.104 0.593486797142 gnomAD-4.0.0 6.17016E-06 None None None None N None 0 0 None 0 1.77099E-04 None 0 0 9.00703E-07 0 1.65942E-05
V/A 23366 Ig-129 22 rs372782502 0.848 -1.931 0.994 N 0.683 0.369 0.497679007273 gnomAD-2.1.1 3.01745E-04 None None None None N None 0 0 None 0 0 None 2.4521E-03 None 0 0 0
V/A 23366 Ig-129 22 rs372782502 0.848 -1.931 0.994 N 0.683 0.369 0.497679007273 gnomAD-3.1.2 5.26E-05 None None None None N None 0 0 0 0 0 None 0 0 0 1.65906E-03 0
V/A 23366 Ig-129 22 rs372782502 0.848 -1.931 0.994 N 0.683 0.369 0.497679007273 1000 genomes 9.98403E-04 None None None None N None 0 0 None None 0 0 None None None 5.1E-03 None
V/A 23366 Ig-129 22 rs372782502 0.848 -1.931 0.994 N 0.683 0.369 0.497679007273 gnomAD-4.0.0 1.12193E-04 None None None None N None 0 0 None 0 0 None 0 0 0 1.86715E-03 1.7609E-04
V/E 23366 Ig-129 22 rs372782502 0.9945 -2.582 0.999 N 0.841 0.682 0.785853343848 gnomAD-2.1.1 3.19E-05 None None None None N None 0 1.17924E-03 None 0 0 None 0 None 0 0 0
V/E 23366 Ig-129 22 rs372782502 0.9945 -2.582 0.999 N 0.841 0.682 0.785853343848 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
V/E 23366 Ig-129 22 rs372782502 0.9945 -2.582 0.999 N 0.841 0.682 0.785853343848 gnomAD-4.0.0 1.23979E-06 None None None None N None 0 3.33511E-05 None 0 0 None 0 0 0 0 0
V/M 23366 Ig-129 22 rs1238454141 0.7459 -0.195 0.998 N 0.72 0.306 0.388334884743 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
V/M 23366 Ig-129 22 rs1238454141 0.7459 -0.195 0.998 N 0.72 0.306 0.388334884743 gnomAD-4.0.0 4.77649E-06 None None None None N None 0 0 None 4.76917E-05 0 None 0 0 2.86007E-06 0 3.0248E-05
I/T 23655 Ig-130 19 rs794729488 0.9605 None 1.0 N 0.835 0.445 0.586935410679 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/T 23655 Ig-130 19 rs794729488 0.9605 None 1.0 N 0.835 0.445 0.586935410679 gnomAD-4.0.0 1.30221E-05 None None None None N None 0 0 None 0 0 None 0 0 1.78064E-05 0 0
A/G 24051 Ig-131 23 rs749531610 0.2576 -1.776 1.0 N 0.694 0.37 0.208000267992 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
A/G 24051 Ig-131 23 rs749531610 0.2576 -1.776 1.0 N 0.694 0.37 0.208000267992 gnomAD-4.0.0 1.59223E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85946E-06 0 0
A/T 24051 Ig-131 23 rs1443600141 0.5396 -1.394 1.0 N 0.815 0.385 0.18995819373 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
A/T 24051 Ig-131 23 rs1443600141 0.5396 -1.394 1.0 N 0.815 0.385 0.18995819373 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 24051 Ig-131 23 rs1443600141 0.5396 -1.394 1.0 N 0.815 0.385 0.18995819373 gnomAD-4.0.0 6.19867E-06 None None None None N None 0 0 None 0 0 None 0 0 6.78189E-06 0 3.20338E-05
V/A 24450 Ig-132 20 None 0.8051 None 0.025 N 0.408 0.197 0.342631996419 gnomAD-4.0.0 6.84326E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9959E-07 0 0
V/F 24450 Ig-132 20 rs771025206 0.8208 -0.963 0.983 N 0.771 0.524 0.771652491224 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
V/F 24450 Ig-132 20 rs771025206 0.8208 -0.963 0.983 N 0.771 0.524 0.771652491224 gnomAD-4.0.0 2.7374E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59841E-06 0 0
A/S 25133 Ig-134 23 rs775396902 0.2548 -1.056 0.414 N 0.477 0.311 0.188950314367 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
A/S 25133 Ig-134 23 rs775396902 0.2548 -1.056 0.414 N 0.477 0.311 0.188950314367 gnomAD-4.0.0 1.59163E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85925E-06 0 0
A/V 25133 Ig-134 23 rs772239178 0.3404 0.775 0.958 N 0.801 0.391 0.325533332567 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
A/V 25133 Ig-134 23 rs772239178 0.3404 0.775 0.958 N 0.801 0.391 0.325533332567 gnomAD-4.0.0 1.36856E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79913E-06 0 0
V/A 25532 Ig-135 19 rs55984930 0.7306 -1.552 0.892 N 0.699 0.226 0.507449927524 gnomAD-2.1.1 2.83E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.24E-05 0
V/A 25532 Ig-135 19 rs55984930 0.7306 -1.552 0.892 N 0.699 0.226 0.507449927524 gnomAD-4.0.0 7.5315E-06 None None None None N None 0 0 None 0 0 None 0 0 9.89785E-06 0 0
V/F 25532 Ig-135 19 rs1358589426 0.6349 -1.078 0.967 N 0.813 0.369 0.722803228931 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 9.98E-05 0 None 0 None 0 0 0
V/F 25532 Ig-135 19 rs1358589426 0.6349 -1.078 0.967 N 0.813 0.369 0.722803228931 gnomAD-4.0.0 2.73847E-06 None None None None N None 0 0 None 0 2.52768E-05 None 0 0 8.99734E-07 1.16066E-05 1.65799E-05
V/L 25532 Ig-135 19 None 0.4659 None 0.369 N 0.657 0.194 0.361758802978 gnomAD-4.0.0 6.84618E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99734E-07 0 0
V/L 25819 Ig-136 22 rs764950661 0.2362 None 0.014 N 0.411 0.116 0.300110245524 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
V/L 25819 Ig-136 22 rs764950661 0.2362 None 0.014 N 0.411 0.116 0.300110245524 gnomAD-4.0.0 6.57834E-06 None None None None N None 0 6.56082E-05 None 0 0 None 0 0 0 0 0
V/M 25819 Ig-136 22 rs764950661 0.2379 None 0.942 N 0.69 0.254 0.417334834585 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 0 4.78469E-04
V/M 25819 Ig-136 22 rs764950661 0.2379 None 0.942 N 0.69 0.254 0.417334834585 gnomAD-4.0.0 5.57896E-06 None None None None N None 0 0 None 0 2.23274E-05 None 0 0 5.9344E-06 0 1.60149E-05
I/M 26614 Ig-138 21 None 0.4351 None 0.994 N 0.708 0.248 0.304435445954 gnomAD-4.0.0 1.59147E-06 None None None None N None 0 2.28666E-05 None 0 0 None 0 0 0 0 0
I/V 26614 Ig-138 21 rs998950249 0.1227 None 0.426 N 0.479 0.163 0.335414705075 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/V 26614 Ig-138 21 rs998950249 0.1227 None 0.426 N 0.479 0.163 0.335414705075 gnomAD-4.0.0 1.85923E-06 None None None None N None 2.67001E-05 0 None 0 0 None 0 1.6442E-04 0 0 0
I/L 26901 Ig-139 22 None 0.1814 None 0.58 N 0.513 0.163 0.384752662912 gnomAD-4.0.0 6.84347E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15977E-05 0
I/V 26901 Ig-139 22 rs201562505 0.1122 -1.139 0.02 N 0.304 0.106 None gnomAD-2.1.1 1.49395E-03 None None None None N None 8.27E-05 3.96915E-04 None 3.15159E-02 0 None 6.54E-05 None 0 4.61226E-04 2.11268E-03
I/V 26901 Ig-139 22 rs201562505 0.1122 -1.139 0.02 N 0.304 0.106 None gnomAD-3.1.2 9.92898E-04 None None None None N None 2.41E-05 1.90164E-03 0 2.68012E-02 0 None 0 3.16456E-03 2.94118E-04 2.07039E-04 2.87356E-03
I/V 26901 Ig-139 22 rs201562505 0.1122 -1.139 0.02 N 0.304 0.106 None gnomAD-4.0.0 9.26589E-04 None None None None N None 1.06687E-04 8.17157E-04 None 3.29863E-02 0 None 0 5.28751E-03 2.1532E-04 9.88468E-05 2.67431E-03
A/T 27297 Ig-140 20 rs774451230 0.3411 None 0.984 N 0.734 0.361 0.262662153117 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
A/T 27297 Ig-140 20 rs774451230 0.3411 None 0.984 N 0.734 0.361 0.262662153117 gnomAD-4.0.0 1.85972E-05 None None None None N None 0 0 None 0 0 None 0 0 2.54283E-05 0 0
V/A 27697 Ig-141 22 None 0.7171 None 0.025 N 0.393 0.258 0.379881503574 gnomAD-4.0.0 1.59146E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
I/V 29066 Ig-145 22 rs1702228996 0.1361 None 0.993 N 0.463 0.286 0.384086055536 gnomAD-4.0.0 1.59132E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
A/G 29462 Ig-146 19 None 0.3232 None 0.784 N 0.603 0.206 0.158396225186 gnomAD-4.0.0 1.59121E-06 None None None None N None 0 0 None 0 2.77593E-05 None 0 0 0 0 0
A/T 29462 Ig-146 19 None 0.2554 None 0.425 N 0.59 0.131 0.128392430309 gnomAD-4.0.0 1.5912E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
I/F 29861 Ig-147 20 rs1384879576 0.4674 -1.434 0.497 N 0.696 0.191 0.461144880706 gnomAD-2.1.1 4.12E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/F 29861 Ig-147 20 rs1384879576 0.4674 -1.434 0.497 N 0.696 0.191 0.461144880706 gnomAD-4.0.0 1.37576E-06 None None None None N None 0 2.23644E-05 None 0 0 None 0 1.73491E-04 0 0 0
A/P 30548 Ig-149 17 rs369043548 0.9738 0.729 1.0 N 0.839 0.357 0.252681307341 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 1.11359E-04 None 0 None 0 0 3.31565E-04
A/P 30548 Ig-149 17 rs369043548 0.9738 0.729 1.0 N 0.839 0.357 0.252681307341 gnomAD-4.0.0 6.15812E-06 None None None None N None 0 0 None 0 2.51953E-05 None 0 0 1.79902E-06 3.47826E-05 4.96952E-05
A/V 30548 Ig-149 17 rs553668520 0.2298 1.335 0.996 N 0.755 0.264 0.231873229951 gnomAD-2.1.1 8.76854E-04 None None None None N None 0 5.79E-05 None 0 0 None 6.99438E-03 None 0 0 3.31565E-04
A/V 30548 Ig-149 17 rs553668520 0.2298 1.335 0.996 N 0.755 0.264 0.231873229951 gnomAD-3.1.2 2.8275E-04 None None None None N None 0 0 0 0 0 None 0 0 0 8.91746E-03 0
A/V 30548 Ig-149 17 rs553668520 0.2298 1.335 0.996 N 0.755 0.264 0.231873229951 1000 genomes 1.79712E-03 None None None None N None 0 0 None None 0 0 None None None 9.2E-03 None
A/V 30548 Ig-149 17 rs553668520 0.2298 1.335 0.996 N 0.755 0.264 0.231873229951 gnomAD-4.0.0 4.01566E-04 None None None None N None 1.33358E-05 3.33389E-05 None 0 2.22926E-05 None 0 1.65071E-04 4.23824E-06 6.54456E-03 6.72194E-04
I/T 30947 Ig-150 21 rs566234008 0.4422 -1.807 0.989 N 0.75 0.445 0.52535981233 gnomAD-2.1.1 7.15E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.56E-05 0
I/T 30947 Ig-150 21 rs566234008 0.4422 -1.807 0.989 N 0.75 0.445 0.52535981233 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
I/T 30947 Ig-150 21 rs566234008 0.4422 -1.807 0.989 N 0.75 0.445 0.52535981233 gnomAD-4.0.0 3.71998E-06 None None None None N None 1.33454E-05 0 None 0 0 None 0 0 4.23803E-06 0 0
V/A 31237 Ig-151 20 None 0.708 None 0.09 N 0.689 0.253 0.444202592202 gnomAD-4.0.0 1.59117E-06 None None None None N None 0 0 None 0 0 None 1.88267E-05 0 0 0 0
V/I 31237 Ig-151 20 rs751307668 0.0711 -0.46 0.004 N 0.276 0.042 0.146414634003 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 3.55E-05 0
V/I 31237 Ig-151 20 rs751307668 0.0711 -0.46 0.004 N 0.276 0.042 0.146414634003 gnomAD-3.1.2 1.32E-05 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 2.06954E-04 0
V/I 31237 Ig-151 20 rs751307668 0.0711 -0.46 0.004 N 0.276 0.042 0.146414634003 gnomAD-4.0.0 2.04505E-05 None None None None N None 2.6708E-05 1.66778E-05 None 0 0 None 1.5625E-05 0 2.11896E-05 3.29352E-05 1.60113E-05
V/L 31237 Ig-151 20 rs751307668 0.314 -0.462 0.036 N 0.554 0.046 0.302459207581 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
V/L 31237 Ig-151 20 rs751307668 0.314 -0.462 0.036 N 0.554 0.046 0.302459207581 gnomAD-4.0.0 6.84194E-07 None None None None N None 0 2.23654E-05 None 0 0 None 0 0 0 0 0
A/P 31637 Ig-152 17 rs1238019151 0.9968 None 1.0 N 0.795 0.46 0.438278051908 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/P 31637 Ig-152 17 rs1238019151 0.9968 None 1.0 N 0.795 0.46 0.438278051908 gnomAD-4.0.0 6.57341E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47029E-05 0 0
A/V 31637 Ig-152 17 rs1384723170 0.5738 -0.281 1.0 N 0.769 0.296 0.325263233342 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.49E-05 0
A/V 31637 Ig-152 17 rs1384723170 0.5738 -0.281 1.0 N 0.769 0.296 0.325263233342 gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 0 None 0 0 5.88E-05 0 0
A/V 31637 Ig-152 17 rs1384723170 0.5738 -0.281 1.0 N 0.769 0.296 0.325263233342 gnomAD-4.0.0 7.43667E-06 None None None None I None 0 0 None 0 0 None 0 0 9.32395E-06 0 1.60118E-05
I/M 32726 Ig-155 19 rs750062113 0.28 -1.081 0.901 N 0.683 0.264 0.379193981924 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
I/M 32726 Ig-155 19 rs750062113 0.28 -1.081 0.901 N 0.683 0.264 0.379193981924 gnomAD-4.0.0 1.59121E-06 None None None None I None 0 0 None 0 2.773E-05 None 0 0 0 0 0
I/T 32726 Ig-155 19 rs758088774 0.8362 -2.488 0.722 N 0.701 0.387 0.486352402194 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/T 32726 Ig-155 19 rs758088774 0.8362 -2.488 0.722 N 0.701 0.387 0.486352402194 gnomAD-4.0.0 6.15785E-06 None None None None I None 0 0 None 0 0 None 0 0 7.19584E-06 1.15931E-05 0
I/V 32726 Ig-155 19 None 0.0751 None 0.001 N 0.322 0.075 0.300449992093 gnomAD-4.0.0 1.59122E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02407E-05
C/F 33122 Ig-156 22 rs1692294550 0.8388 None 1.0 D 0.922 0.674 0.870638749041 gnomAD-4.0.0 4.77517E-06 None None disulfide None N None 0 0 None 0 8.32178E-05 None 0 0 0 0 0
C/R 33122 Ig-156 22 None 0.9965 None 1.0 D 0.94 0.708 0.890979346231 gnomAD-4.0.0 1.20032E-06 None None disulfide None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
V/I 33218 Ig-157 16 rs1692185299 0.1054 None 0.014 N 0.467 0.111 0.421184727016 gnomAD-4.0.0 2.66855E-05 None None None None N None 0 0 None 0 0 None 0 0 3.32807E-05 0 3.31367E-05
C/G 33517 Ig-158 22 None 0.7984 None 1.0 D 0.841 0.716 0.915607148917 gnomAD-4.0.0 6.84423E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99637E-07 0 0
C/S 33517 Ig-158 22 None 0.8856 None 0.998 D 0.803 0.741 0.890437381508 gnomAD-4.0.0 6.84423E-07 None None None None N None 0 0 None 0 0 None 0 1.7343E-04 0 0 0
I/T 33617 Ig-159 22 rs1395817779 0.9901 -2.993 1.0 N 0.807 0.545 0.550545596621 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
I/T 33617 Ig-159 22 rs1395817779 0.9901 -2.993 1.0 N 0.807 0.545 0.550545596621 gnomAD-4.0.0 5.47448E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79897E-06 5.79683E-05 1.65673E-05
C/R 34157 Ig-160 21 None 0.9952 None 1.0 N 0.915 0.645 0.866705139298 gnomAD-4.0.0 1.36831E-06 None None disulfide None N None 0 2.23614E-05 None 0 0 None 0 0 8.9941E-07 0 0
C/S 34157 Ig-160 21 rs1690398019 0.9808 None 1.0 N 0.787 0.649 0.765205214495 gnomAD-3.1.2 6.57E-06 None None disulfide None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
C/S 34157 Ig-160 21 rs1690398019 0.9808 None 1.0 N 0.787 0.649 0.765205214495 gnomAD-4.0.0 1.85892E-06 None None disulfide None N None 1.33497E-05 0 None 0 0 None 0 0 1.69509E-06 0 0
V/I 34279 Ig-161 22 rs779989647 0.1429 -0.13 0.489 N 0.592 0.238 0.248417906384 gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
V/I 34279 Ig-161 22 rs779989647 0.1429 -0.13 0.489 N 0.592 0.238 0.248417906384 gnomAD-4.0.0 3.42077E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99413E-07 4.63725E-05 0
V/L 34279 Ig-161 22 rs779989647 0.7416 None 0.247 N 0.705 0.297 0.251639045875 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06697E-04 0
V/L 34279 Ig-161 22 rs779989647 0.7416 None 0.247 N 0.705 0.297 0.251639045875 gnomAD-4.0.0 6.57039E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.06697E-04 0
I/N 34384 Ig-162 22 rs1435527858 0.988 -2.67 0.996 N 0.842 0.641 0.852766357386 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
I/N 34384 Ig-162 22 rs1435527858 0.988 -2.67 0.996 N 0.842 0.641 0.852766357386 gnomAD-4.0.0 1.59184E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85984E-06 0 0
C/S 35150 Ig-164 22 None 0.8617 None 1.0 D 0.849 0.697 0.735643650146 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
C/Y 35150 Ig-164 22 rs554953169 0.9514 -1.672 1.0 D 0.935 0.661 0.798006484268 gnomAD-2.1.1 3.61E-05 None None None None N None 0 0 None 0 0 None 2.61438E-04 None 0 8.86E-06 0
C/Y 35150 Ig-164 22 rs554953169 0.9514 -1.672 1.0 D 0.935 0.661 0.798006484268 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 6.21891E-04 0
C/Y 35150 Ig-164 22 rs554953169 0.9514 -1.672 1.0 D 0.935 0.661 0.798006484268 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
C/Y 35150 Ig-164 22 rs554953169 0.9514 -1.672 1.0 D 0.935 0.661 0.798006484268 gnomAD-4.0.0 3.65547E-05 None None None None N None 0 0 None 0 0 None 0 1.64962E-04 2.03409E-05 3.73306E-04 0
C/G 35305 Ig-165 20 rs1243651023 0.6051 -1.872 0.995 D 0.86 0.693 0.844537292851 gnomAD-2.1.1 4.02E-06 None None disulfide None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
C/G 35305 Ig-165 20 rs1243651023 0.6051 -1.872 0.995 D 0.86 0.693 0.844537292851 gnomAD-4.0.0 1.59093E-06 None None disulfide None N None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
C/S 35305 Ig-165 20 rs1323470679 0.7984 -1.557 0.983 D 0.809 0.633 0.709820000554 gnomAD-2.1.1 4.02E-06 None None disulfide None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
C/S 35305 Ig-165 20 rs1323470679 0.7984 -1.557 0.983 D 0.809 0.633 0.709820000554 gnomAD-4.0.0 2.05244E-06 None None disulfide None N None 0 0 None 0 0 None 0 0 0 3.47794E-05 0
C/Y 35305 Ig-165 20 rs1323470679 0.8855 -1.147 0.944 D 0.858 0.478 0.757083932737 gnomAD-2.1.1 4.02E-06 None None disulfide None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
C/Y 35305 Ig-165 20 rs1323470679 0.8855 -1.147 0.944 D 0.858 0.478 0.757083932737 gnomAD-4.0.0 6.84148E-07 None None disulfide None N None 0 0 None 0 2.51915E-05 None 0 0 0 0 0
V/F 35441 Ig-166 22 None 0.3315 None 0.278 N 0.793 0.239 0.342631996419 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
A/G 35628 Ig-167 22 rs748131753 0.2611 -1.565 1.0 N 0.728 0.383 0.331619326243 gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.66E-05 0
A/G 35628 Ig-167 22 rs748131753 0.2611 -1.565 1.0 N 0.728 0.383 0.331619326243 gnomAD-4.0.0 6.84145E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99399E-06 0 0
C/G 35723 Ig-168 22 rs1687597849 0.6328 None 1.0 D 0.872 0.724 0.860559553989 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.54E-05 0 0 0 None 0 0 0 0 0
C/G 35723 Ig-168 22 rs1687597849 0.6328 None 1.0 D 0.872 0.724 0.860559553989 gnomAD-4.0.0 3.04468E-06 None None None None N None 0 6.14553E-05 None 0 0 None 0 0 1.20491E-06 0 3.40229E-05
C/S 35918 Ig-169 22 rs1053743149 0.8349 -1.763 1.0 D 0.807 0.645 0.774586832184 gnomAD-3.1.2 6.57E-06 None None None -1.785(OBSL1) -1.353(OBSCN) N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
C/S 35918 Ig-169 22 rs1053743149 0.8349 -1.763 1.0 D 0.807 0.645 0.774586832184 gnomAD-4.0.0 6.57056E-06 None None None -1.785(OBSL1) -1.353(OBSCN) N None 0 0 None 0 0 None 0 0 1.46972E-05 0 0
C/Y 35918 Ig-169 22 rs193212275 0.9781 -1.373 1.0 D 0.917 0.594 None gnomAD-2.1.1 9.64E-05 None None None -1.32(OBSL1) -0.626(OBSCN) N None 1.07607E-03 0 None 0 0 None 3.27E-05 None 0 0 0
C/Y 35918 Ig-169 22 rs193212275 0.9781 -1.373 1.0 D 0.917 0.594 None gnomAD-3.1.2 2.82534E-04 None None None -1.32(OBSL1) -0.626(OBSCN) N None 1.03784E-03 0 0 0 0 None 0 0 0 0 0
C/Y 35918 Ig-169 22 rs193212275 0.9781 -1.373 1.0 D 0.917 0.594 None 1000 genomes 3.99361E-04 None None None -1.32(OBSL1) -0.626(OBSCN) N None 1.5E-03 0 None None 0 0 None None None 0 None
C/Y 35918 Ig-169 22 rs193212275 0.9781 -1.373 1.0 D 0.917 0.594 None gnomAD-4.0.0 5.08117E-05 None None None -1.32(OBSL1) -0.626(OBSCN) N None 9.8622E-04 1.66656E-05 None 0 0 None 0 0 0 5.49197E-05 3.20092E-05

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.