Structural position:

  • Domain Type: Ig
  • Aligned Position: 40
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand B

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
G/D 31 Ig-1 26 None 0.984 None 1.0 D 0.849 None 0.646441920909 gnomAD-4.0.0 1.59167E-06 None None None -1.557(TCAP) N None 0 0 None 0 0 None 0 0 2.85838E-06 0 0
G/E 129 Ig-2 26 None 0.9715 None 1.0 D 0.813 0.776 0.860050144884 gnomAD-4.0.0 1.20032E-06 None None None -1.372(TCAP) N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/R 129 Ig-2 26 rs727503708 0.9869 None 0.986 D 0.59 0.88 0.867954797308 gnomAD-4.0.0 1.59097E-06 None None None -2.1(TCAP) N None 0 0 None 0 0 None 0 0 2.85727E-06 0 0
G/E 968 Ig-3 26 None 0.9962 None 0.999 D 0.793 0.693 0.795966037868 gnomAD-4.0.0 6.84079E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
G/V 968 Ig-3 26 None 0.9886 None 0.997 D 0.789 0.69 0.923725460125 gnomAD-4.0.0 6.84079E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99308E-07 0 0
G/S 1107 Ig-4 26 rs767741769 0.8705 -0.654 1.0 D 0.837 0.731 0.600369781234 gnomAD-2.1.1 2.83E-05 None None None None I None 4.01E-05 0 None 0 0 None 0 None 0 4.66E-05 1.38581E-04
G/S 1107 Ig-4 26 rs767741769 0.8705 -0.654 1.0 D 0.837 0.731 0.600369781234 gnomAD-3.1.2 3.94E-05 None None None None I None 7.24E-05 1.31079E-04 0 0 0 None 0 0 1.47E-05 0 0
G/S 1107 Ig-4 26 rs767741769 0.8705 -0.654 1.0 D 0.837 0.731 0.600369781234 gnomAD-4.0.0 1.36311E-05 None None None None I None 5.34117E-05 5.0015E-05 None 0 0 None 0 1.64366E-04 1.10168E-05 0 1.60041E-05
G/R 1316 Ig-5 26 None 0.997 None 1.0 D 0.829 0.874 0.893698342419 gnomAD-4.0.0 9.60327E-06 None None None None I None 0 0 None 0 0 None 0 0 1.05008E-05 0 0
G/S 1482 Ig-6 26 None 0.9675 None 0.991 D 0.784 0.652 0.543209242439 gnomAD-4.0.0 3.42052E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49666E-06 0 0
G/V 1581 Ig-7 26 None 0.9976 None 1.0 D 0.817 0.802 0.790211260466 gnomAD-4.0.0 1.59064E-06 None None None None I None 0 2.28655E-05 None 0 0 None 0 0 0 0 0
G/D 1730 Ig-8 28 rs1485641698 0.9825 -1.856 1.0 D 0.842 0.887 0.615685111792 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 5.46E-05 None 0 None 0 0 0
G/D 1730 Ig-8 28 rs1485641698 0.9825 -1.856 1.0 D 0.842 0.887 0.615685111792 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.9253E-04 None 0 0 0 0 0
G/D 1730 Ig-8 28 rs1485641698 0.9825 -1.856 1.0 D 0.842 0.887 0.615685111792 gnomAD-4.0.0 6.57022E-06 None None None None N None 0 0 None 0 1.9253E-04 None 0 0 0 0 0
G/D 1866 Ig-9 26 rs2092214175 0.9955 None 1.0 D 0.847 0.889 0.651643192601 gnomAD-4.0.0 8.20898E-06 None None None None I None 0 0 None 0 0 None 0 0 1.07916E-05 0 0
G/R 2103 Ig-10 26 rs2092130428 0.9986 None 1.0 D 0.839 0.875 0.802305792746 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/R 2103 Ig-10 26 rs2092130428 0.9986 None 1.0 D 0.839 0.875 0.802305792746 gnomAD-4.0.0 2.47851E-06 None None None None N None 2.6703E-05 0 None 0 0 None 0 0 1.69494E-06 0 0
V/A 2470 Ig-14 26 rs1257401940 0.3109 -0.513 0.002 N 0.134 0.257 0.460352466543 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/A 2470 Ig-14 26 rs1257401940 0.3109 -0.513 0.002 N 0.134 0.257 0.460352466543 gnomAD-4.0.0 1.59071E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
V/F 2470 Ig-14 26 rs1228257559 0.2647 None 0.966 N 0.443 0.391 0.822638020212 gnomAD-4.0.0 3.42054E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49659E-06 0 0
V/I 2470 Ig-14 26 rs1228257559 0.0937 None 0.051 N 0.227 0.238 0.458101713262 gnomAD-4.0.0 5.47287E-06 None None None None N None 0 0 None 0 2.01684E-04 None 0 0 0 0 0
H/R 2558 Ig-15 26 rs1175796012 0.3144 -0.354 1.0 N 0.679 0.592 0.377274123778 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.81E-06 0
H/R 2558 Ig-15 26 rs1175796012 0.3144 -0.354 1.0 N 0.679 0.592 0.377274123778 gnomAD-4.0.0 2.05241E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69797E-06 0 0
N/S 2645 Ig-16 25 rs572589233 0.1307 0.179 0.999 N 0.63 0.305 0.165133752707 gnomAD-2.1.1 3.98E-06 None None None None N None 6.15E-05 0 None 0 0 None 0 None 0 0 0
N/S 2645 Ig-16 25 rs572589233 0.1307 0.179 0.999 N 0.63 0.305 0.165133752707 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 4.78011E-04
N/S 2645 Ig-16 25 rs572589233 0.1307 0.179 0.999 N 0.63 0.305 0.165133752707 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
N/S 2645 Ig-16 25 rs572589233 0.1307 0.179 0.999 N 0.63 0.305 0.165133752707 gnomAD-4.0.0 3.09785E-06 None None None None N None 3.99797E-05 0 None 0 0 None 0 0 8.47498E-07 0 1.6E-05
H/Y 2732 Ig-17 26 None 0.202 None 0.997 D 0.49 0.514 0.507987536778 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/D 2907 Ig-19 26 None 0.9301 None 1.0 N 0.688 0.605 0.411932830014 gnomAD-4.0.0 1.59052E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
H/N 2907 Ig-19 26 None 0.6666 None 0.999 N 0.631 0.476 0.407901774203 gnomAD-4.0.0 1.59052E-06 None None None None N None 0 0 None 0 2.77362E-05 None 0 0 0 0 0
H/Q 2907 Ig-19 26 None 0.9049 None 1.0 D 0.701 0.402 0.340992353424 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/R 3264 Ig-23 26 rs370190599 0.9923 -0.738 1.0 D 0.807 0.849 0.875560046438 gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 0 None 0 None 4.62E-05 1.77E-05 0
G/R 3264 Ig-23 26 rs370190599 0.9923 -0.738 1.0 D 0.807 0.849 0.875560046438 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
G/R 3264 Ig-23 26 rs370190599 0.9923 -0.738 1.0 D 0.807 0.849 0.875560046438 gnomAD-4.0.0 4.95692E-06 None None None None N None 0 0 None 0 0 None 1.56221E-05 0 5.93224E-06 0 0
G/V 3370 Ig-24 26 None 0.9661 None 1.0 D 0.789 0.82 0.943895591927 gnomAD-4.0.0 1.5906E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85682E-06 0 0
G/D 3490 Ig-25 26 rs970694174 0.9773 -0.618 None None None 0.586 None gnomAD-2.1.1 3.19E-05 None None None None I None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
G/D 3490 Ig-25 26 rs970694174 0.9773 -0.618 None None None 0.586 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/D 3490 Ig-25 26 rs970694174 0.9773 -0.618 None None None 0.586 None gnomAD-4.0.0 6.57454E-06 None None None None I None 2.41488E-05 0 None 0 0 None 0 0 0 0 0
G/S 3490 Ig-25 26 rs2087749364 0.5034 None None None None 0.468 None gnomAD-4.0.0 5.47355E-06 None None None None I None 0 0 None 0 1.76367E-04 None 0 0 8.99475E-07 0 0
D/G 3685 Ig-26 26 None 0.1236 None None None None 0.082 None gnomAD-4.0.0 2.73687E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59778E-06 0 0
G/D 3845 Ig-27 26 None 0.8418 None 1.0 D 0.879 0.637 None gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/S 3845 Ig-27 26 None 0.3531 None 1.0 D 0.819 0.622 None gnomAD-4.0.0 1.59134E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85845E-06 0 0
G/R 3963 Ig-28 26 rs1000514079 0.9809 None 1.0 D 0.828 0.618 0.476754456241 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/R 3963 Ig-28 26 rs1000514079 0.9809 None 1.0 D 0.828 0.618 0.476754456241 gnomAD-4.0.0 6.57298E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46981E-05 0 0
S/N 4725 Ig-30 26 rs1179360335 0.0907 0.023 0.014 N 0.365 0.118 0.0611884634855 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/N 4725 Ig-30 26 rs1179360335 0.0907 0.023 0.014 N 0.365 0.118 0.0611884634855 gnomAD-4.0.0 1.36867E-06 None None None None I None 0 2.23714E-05 None 0 0 None 0 0 8.99538E-07 0 0
G/E 4820 Ig-31 26 rs376364888 0.9868 -0.599 1.0 D 0.795 0.758 None gnomAD-2.1.1 1.78E-05 None None None None I None 0 2.83E-05 None 0 0 None 0 None 0 3.12E-05 0
G/E 4820 Ig-31 26 rs376364888 0.9868 -0.599 1.0 D 0.795 0.758 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 6.55E-05 0 0 0 None 0 0 1.47E-05 0 4.77555E-04
G/E 4820 Ig-31 26 rs376364888 0.9868 -0.599 1.0 D 0.795 0.758 None gnomAD-4.0.0 1.30145E-05 None None None None I None 0 1.66756E-05 None 3.37838E-05 0 None 0 1.64528E-04 1.18669E-05 0 6.40451E-05
G/R 4820 Ig-31 26 rs1247947470 0.9837 None 1.0 D 0.795 0.781 0.899262121513 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/R 4820 Ig-31 26 rs1247947470 0.9837 None 1.0 D 0.795 0.781 0.899262121513 gnomAD-4.0.0 2.73695E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59796E-06 0 0
G/C 5007 Ig-33 27 None 0.9775 None 1.0 D 0.707 0.81 0.913927925356 gnomAD-4.0.0 1.59307E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86087E-06 0 0
G/S 5007 Ig-33 27 None 0.8626 None 1.0 D 0.831 0.717 0.585017178307 gnomAD-4.0.0 1.59307E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43365E-05 0
G/V 5007 Ig-33 27 None 0.9625 None 1.0 D 0.784 0.804 0.9377020764 gnomAD-4.0.0 2.73816E-06 None None None None I None 0 0 None 0 2.52832E-05 None 0 0 1.79943E-06 1.15988E-05 0
G/C 5100 Ig-34 26 rs2081094538 0.9501 None 1.0 D 0.717 0.818 0.893786415199 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
G/D 5100 Ig-34 26 rs773928522 0.9897 0.333 1.0 D 0.815 0.825 0.635064254492 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
G/D 5100 Ig-34 26 rs773928522 0.9897 0.333 1.0 D 0.815 0.825 0.635064254492 gnomAD-4.0.0 6.84813E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00087E-07 0 0
G/V 5100 Ig-34 26 None 0.9628 None 1.0 D 0.773 0.879 0.934545104794 gnomAD-4.0.0 1.36963E-05 None None None None I None 0 0 None 0 0 None 0 0 1.71016E-05 1.16252E-05 0
G/E 5193 Ig-35 26 rs1345800010 0.9936 -0.677 1.0 D 0.793 0.773 0.0551355673512 gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
G/E 5193 Ig-35 26 rs1345800010 0.9936 -0.677 1.0 D 0.793 0.773 0.0551355673512 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
G/E 5193 Ig-35 26 rs1345800010 0.9936 -0.677 1.0 D 0.793 0.773 0.0551355673512 gnomAD-4.0.0 1.54937E-05 None None None None I None 0 0 None 0 0 None 0 0 2.0344E-05 0 1.60123E-05
G/R 5193 Ig-35 26 None 0.9944 None 1.0 D 0.79 0.832 0.223847106136 gnomAD-4.0.0 1.36845E-06 None None None None I None 0 0 None 0 2.51927E-05 None 0 0 8.99505E-07 0 0
G/S 5286 Ig-36 26 rs1409273228 0.8277 None 1.0 D 0.821 0.765 0.584274139494 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/S 5286 Ig-36 26 rs1409273228 0.8277 None 1.0 D 0.821 0.765 0.584274139494 gnomAD-4.0.0 5.57709E-06 None None None None N None 0 0 None 0 0 None 0 0 5.93323E-06 0 3.20205E-05
G/D 5382 Ig-37 26 None 0.9955 None 1.0 D 0.833 0.574 0.647653543843 gnomAD-4.0.0 6.84355E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99549E-07 0 0
G/V 5382 Ig-37 26 None 0.9851 None 1.0 D 0.781 0.602 0.784472299234 gnomAD-4.0.0 6.84355E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99549E-07 0 0
G/R 5475 Ig-38 26 rs1232661197 0.9811 -0.336 1.0 D 0.795 0.678 0.785467031908 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 2.75482E-04 None 0 0 1.3125E-06 0 0
G/V 5475 Ig-38 26 None 0.8948 None 1.0 D 0.758 0.672 0.813948600782 gnomAD-4.0.0 1.36899E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99635E-07 1.16069E-05 0
G/D 5569 Ig-39 27 rs761085549 0.979 -0.496 1.0 D 0.802 0.611 0.667121220962 gnomAD-2.1.1 7.15E-06 None None None None I None 0 2.83E-05 None 0 0 None 3.27E-05 None 0 0 0
G/D 5569 Ig-39 27 rs761085549 0.979 -0.496 1.0 D 0.802 0.611 0.667121220962 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
G/D 5569 Ig-39 27 rs761085549 0.979 -0.496 1.0 D 0.802 0.611 0.667121220962 gnomAD-4.0.0 2.56247E-06 None None None None I None 0 1.69497E-05 None 0 0 None 0 0 0 1.34037E-05 0
G/S 5569 Ig-39 27 rs1311137790 0.7142 None 1.0 D 0.815 0.53 0.552085806491 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 2.07383E-04 0
G/S 5569 Ig-39 27 rs1311137790 0.7142 None 1.0 D 0.815 0.53 0.552085806491 gnomAD-4.0.0 6.40605E-06 None None None None I None 0 0 None 0 0 None 0 0 4.78622E-06 4.02134E-05 0
G/D 5662 Ig-40 26 rs760089168 0.9851 -0.682 1.0 D 0.799 0.536 0.655917873618 gnomAD-2.1.1 2.14E-05 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 3.13E-05 0
G/D 5662 Ig-40 26 rs760089168 0.9851 -0.682 1.0 D 0.799 0.536 0.655917873618 gnomAD-3.1.2 3.29E-05 None None None None I None 0 0 0 0 0 None 0 0 5.88E-05 2.07211E-04 0
G/D 5662 Ig-40 26 rs760089168 0.9851 -0.682 1.0 D 0.799 0.536 0.655917873618 gnomAD-4.0.0 2.47895E-05 None None None None I None 0 0 None 0 0 None 0 3.29164E-04 2.62773E-05 3.29402E-05 6.40512E-05
G/C 5755 Ig-41 26 rs771267628 0.9806 -0.55 0.953 D 0.687 0.791 0.854352048779 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
G/C 5755 Ig-41 26 rs771267628 0.9806 -0.55 0.953 D 0.687 0.791 0.854352048779 gnomAD-4.0.0 5.47465E-06 None None None None I None 0 0 None 0 0 None 0 0 7.19632E-06 0 0
G/R 5755 Ig-41 26 None 0.9957 None 1.0 D 0.76 0.827 0.836006858035 gnomAD-4.0.0 4.79032E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29678E-06 0 0
G/A 5848 Ig-42 26 None 0.6835 None 1.0 D 0.777 0.665 0.5711029235 gnomAD-4.0.0 6.84237E-07 None None None None N None 0 0 None 0 0 None 1.87259E-05 0 0 0 0
G/E 5848 Ig-42 26 rs185962498 0.9878 -0.23 1.0 D 0.811 0.621 None gnomAD-2.1.1 1.92689E-04 None None None None N None 8.26E-05 8.49E-05 None 0 2.204E-03 None 6.54E-05 None 0 0 5.61482E-04
G/E 5848 Ig-42 26 rs185962498 0.9878 -0.23 1.0 D 0.811 0.621 None gnomAD-3.1.2 2.82954E-04 None None None None N None 4.83E-05 1.63977E-03 0 0 1.93648E-03 None 0 0 1.47E-05 0 2.39464E-03
G/E 5848 Ig-42 26 rs185962498 0.9878 -0.23 1.0 D 0.811 0.621 None 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 2E-03 0 None None None 0 None
G/E 5848 Ig-42 26 rs185962498 0.9878 -0.23 1.0 D 0.811 0.621 None gnomAD-4.0.0 1.53697E-04 None None None None N None 4.00171E-05 4.50135E-04 None 0 1.15963E-03 None 0 0 4.23843E-06 1.09801E-05 2.56106E-03
G/E 5944 Ig-43 26 rs879222472 0.9987 None 1.0 D 0.806 0.818 None gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
G/E 5944 Ig-43 26 rs879222472 0.9987 None 1.0 D 0.806 0.818 None gnomAD-4.0.0 4.95842E-06 None None None None I None 0 0 None 0 0 None 0 0 6.78158E-06 0 0
G/R 5944 Ig-43 26 rs879142796 0.9981 -0.252 1.0 D 0.803 0.846 0.907221789318 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14837E-04 0 None 0 0 None 0 None 0 0 0
G/R 5944 Ig-43 26 rs879142796 0.9981 -0.252 1.0 D 0.803 0.846 0.907221789318 gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
G/R 5944 Ig-43 26 rs879142796 0.9981 -0.252 1.0 D 0.803 0.846 0.907221789318 gnomAD-4.0.0 3.84453E-06 None None None None I None 5.07614E-05 0 None 0 0 None 0 0 0 0 0
G/V 5944 Ig-43 26 rs879222472 0.9956 0.124 1.0 D 0.781 0.845 0.95689222792 gnomAD-2.1.1 1.62E-05 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 2.7E-05 0
G/V 5944 Ig-43 26 rs879222472 0.9956 0.124 1.0 D 0.781 0.845 0.95689222792 gnomAD-4.0.0 7.52716E-06 None None None None I None 2.98846E-05 2.23674E-05 None 0 0 None 0 0 7.19641E-06 0 1.65695E-05
G/S 6037 Ig-44 26 rs377578914 0.6295 -0.227 1.0 D 0.815 0.66 None gnomAD-2.1.1 4.08E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.03E-06 0
G/S 6037 Ig-44 26 rs377578914 0.6295 -0.227 1.0 D 0.815 0.66 None gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
G/S 6037 Ig-44 26 rs377578914 0.6295 -0.227 1.0 D 0.815 0.66 None gnomAD-4.0.0 3.72169E-06 None None None None I None 0 0 None 0 0 None 0 0 5.08852E-06 0 0
G/E 6224 Ig-46 26 rs1168353457 0.9803 -0.565 1.0 D 0.777 0.7 0.800560755456 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 8.9E-06 0
G/E 6224 Ig-46 26 rs1168353457 0.9803 -0.565 1.0 D 0.777 0.7 0.800560755456 gnomAD-4.0.0 1.59173E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85927E-06 0 0
G/R 6224 Ig-46 26 rs2154307306 0.9734 None 1.0 D 0.778 0.715 0.859625135514 gnomAD-4.0.0 1.59172E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85925E-06 0 0
G/D 6506 Ig-49 26 rs1401335381 0.9885 -0.042 1.0 D 0.814 0.783 0.594932130068 gnomAD-2.1.1 8.08E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.79E-05 0
G/D 6506 Ig-49 26 rs1401335381 0.9885 -0.042 1.0 D 0.814 0.783 0.594932130068 gnomAD-4.0.0 2.05353E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69905E-06 0 0
G/E 6599 Ig-50 26 None 0.9878 None 1.0 D 0.811 0.723 0.705268275649 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
G/V 6693 Ig-51 27 None 0.9456 None 1.0 D 0.763 0.598 0.804695419218 gnomAD-4.0.0 1.59303E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43419E-05 0
G/E 6786 Ig-52 26 None 0.9956 None 1.0 D 0.812 0.585 0.849335212085 gnomAD-4.0.0 1.59698E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86801E-06 0 0
G/R 6786 Ig-52 26 rs1191785544 0.9929 -0.292 1.0 D 0.805 0.622 0.894553961046 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 3.29E-05 None 0 0 0
G/R 6786 Ig-52 26 rs1191785544 0.9929 -0.292 1.0 D 0.805 0.622 0.894553961046 gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
G/R 6786 Ig-52 26 rs1191785544 0.9929 -0.292 1.0 D 0.805 0.622 0.894553961046 gnomAD-4.0.0 2.57061E-06 None None None None I None 1.69653E-05 0 None 0 0 None 0 0 0 1.34789E-05 0
G/D 6879 Ig-53 26 rs370099653 0.9151 -0.56 1.0 D 0.796 0.651 None gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/D 6879 Ig-53 26 rs370099653 0.9151 -0.56 1.0 D 0.796 0.651 None gnomAD-4.0.0 4.06019E-06 None None None None I None 0 0 None 0 0 None 0 0 4.81986E-06 0 0
G/D 6973 Ig-54 26 rs760012943 0.9899 -0.503 1.0 D 0.807 0.698 0.65404562455 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
G/D 6973 Ig-54 26 rs760012943 0.9899 -0.503 1.0 D 0.807 0.698 0.65404562455 gnomAD-4.0.0 3.18492E-06 None None None None I None 0 0 None 0 2.77423E-05 None 0 0 2.86048E-06 0 0
G/S 6973 Ig-54 26 rs1320591488 0.8477 -0.253 1.0 D 0.815 0.613 0.549504238362 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.58E-05 None 0 None 0 0 0
G/S 6973 Ig-54 26 rs1320591488 0.8477 -0.253 1.0 D 0.815 0.613 0.549504238362 gnomAD-4.0.0 1.36884E-06 None None None None I None 0 0 None 0 2.52042E-05 None 0 0 8.99671E-07 0 0
G/E 7069 Ig-55 26 rs368334249 0.9711 -0.014 1.0 D 0.777 0.687 None gnomAD-2.1.1 4.03E-06 None None None None I None 6.47E-05 0 None 0 0 None 0 None 0 0 0
G/E 7069 Ig-55 26 rs368334249 0.9711 -0.014 1.0 D 0.777 0.687 None gnomAD-3.1.2 2.63E-05 None None None None I None 9.65E-05 0 0 0 0 None 0 0 0 0 0
G/E 7069 Ig-55 26 rs368334249 0.9711 -0.014 1.0 D 0.777 0.687 None gnomAD-4.0.0 6.19761E-06 None None None None I None 1.33259E-04 0 None 0 0 None 0 0 0 0 0
G/R 7069 Ig-55 26 None 0.9624 None 1.0 D 0.765 0.727 0.871408021018 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 2.75482E-04 None 0 0 1.3125E-06 0 0
G/R 7162 Ig-56 26 rs1288993592 0.9895 -0.487 1.0 D 0.805 0.642 0.883724802589 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.94E-06 0
G/R 7162 Ig-56 26 rs1288993592 0.9895 -0.487 1.0 D 0.805 0.642 0.883724802589 gnomAD-4.0.0 1.59343E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86084E-06 0 0
G/A 7255 Ig-57 26 None 0.5499 None 0.974 D 0.552 0.596 0.5551182358 gnomAD-4.0.0 1.36861E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79907E-06 0 0
G/V 7255 Ig-57 26 rs1429557332 0.9456 0.171 1.0 D 0.786 0.675 0.849212857558 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66445E-04
G/V 7255 Ig-57 26 rs1429557332 0.9456 0.171 1.0 D 0.786 0.675 0.849212857558 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/V 7255 Ig-57 26 rs1429557332 0.9456 0.171 1.0 D 0.786 0.675 0.849212857558 gnomAD-4.0.0 2.47917E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39072E-06 0 0
G/E 7348 Ig-58 26 None 0.986 None 0.998 D 0.559 0.712 0.774179987323 gnomAD-4.0.0 6.84505E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99692E-07 0 0
G/R 7348 Ig-58 26 rs1273201877 0.9853 -0.443 1.0 D 0.773 0.785 0.871131940551 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
G/S 7634 Ig-61 27 rs1472650919 0.6212 -0.635 0.999 D 0.769 0.546 0.578813787709 gnomAD-2.1.1 6.37E-05 None None None None I None 0 0 None 0 0 None 0 None 0 1.29567E-04 0
G/S 7634 Ig-61 27 rs1472650919 0.6212 -0.635 0.999 D 0.769 0.546 0.578813787709 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
G/S 7634 Ig-61 27 rs1472650919 0.6212 -0.635 0.999 D 0.769 0.546 0.578813787709 gnomAD-4.0.0 3.0448E-06 None None None None I None 0 0 None 0 0 None 0 0 2.40987E-06 4.69616E-05 0
G/E 7727 Ig-62 26 rs763907919 0.9974 0.043 1.0 D 0.828 0.787 0.836363966263 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
G/E 7727 Ig-62 26 rs763907919 0.9974 0.043 1.0 D 0.828 0.787 0.836363966263 gnomAD-4.0.0 3.18505E-06 None None None None I None 0 0 None 0 0 None 0 0 5.72033E-06 0 0
G/E 7914 Ig-64 26 None 0.9918 None 1.0 D 0.804 0.637 0.70494342197 gnomAD-4.0.0 4.80129E-06 None None None None I None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
G/D 8010 Ig-65 26 None 0.9832 None 1.0 D 0.812 0.595 0.645590637679 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/R 8010 Ig-65 26 None 0.9779 None 1.0 D 0.792 0.617 0.814818510161 gnomAD-4.0.0 2.40064E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 3.66327E-05
G/S 8103 Ig-66 26 None 0.8181 None 1.0 D 0.829 0.663 0.542721108892 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
G/A 8385 Ig-69 26 rs775560531 0.6517 -0.018 0.999 D 0.608 0.582 0.518199804421 gnomAD-2.1.1 2.02E-05 None None None None I None 0 0 None 0 0 None 1.63741E-04 None 0 0 0
G/A 8385 Ig-69 26 rs775560531 0.6517 -0.018 0.999 D 0.608 0.582 0.518199804421 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07555E-04 0
G/A 8385 Ig-69 26 rs775560531 0.6517 -0.018 0.999 D 0.608 0.582 0.518199804421 gnomAD-4.0.0 1.42573E-05 None None None None I None 0 0 None 0 0 None 0 0 0 2.41694E-04 1.60179E-05
G/C 8385 Ig-69 26 None 0.9557 None 1.0 D 0.688 0.629 0.824748956951 gnomAD-4.0.0 4.79094E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29744E-06 0 0
G/S 8385 Ig-69 26 rs1479989590 0.7115 -0.269 1.0 D 0.783 0.605 0.53563189239 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 0 0
G/S 8385 Ig-69 26 rs1479989590 0.7115 -0.269 1.0 D 0.783 0.605 0.53563189239 gnomAD-4.0.0 1.36884E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.3204E-05 0
G/E 8575 Ig-71 27 None 0.9894 None 1.0 D 0.823 0.864 0.713204199129 gnomAD-4.0.0 1.59856E-06 None None None None I None 0 0 None 0 0 None 1.88829E-05 0 0 0 0
G/R 8575 Ig-71 27 rs397517517 0.9866 -0.425 1.0 D 0.809 0.819 0.816574466228 gnomAD-2.1.1 8.25E-06 None None None None I None 0 2.96E-05 None 0 0 None 0 None 0 9.16E-06 0
G/R 8575 Ig-71 27 rs397517517 0.9866 -0.425 1.0 D 0.809 0.819 0.816574466228 gnomAD-3.1.2 1.97E-05 None None None None I None 0 6.56E-05 0 0 0 None 0 0 2.94E-05 0 0
G/R 8575 Ig-71 27 rs397517517 0.9866 -0.425 1.0 D 0.809 0.819 0.816574466228 gnomAD-4.0.0 9.93517E-06 None None None None I None 0 3.36146E-05 None 0 0 None 0 0 1.10343E-05 0 1.60452E-05
G/A 8668 Ig-72 26 None 0.7654 None 1.0 D 0.775 0.69 0.562354153293 gnomAD-4.0.0 1.59146E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43303E-05 0
G/S 8761 Ig-73 26 rs369385294 0.3171 -0.776 1.0 D 0.842 0.667 None gnomAD-2.1.1 5.37E-05 None None None None N None 4.14E-05 0 None 0 0 None 0 None 0 1.09714E-04 0
G/S 8761 Ig-73 26 rs369385294 0.3171 -0.776 1.0 D 0.842 0.667 None gnomAD-3.1.2 5.26E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 7.35E-05 0 0
G/S 8761 Ig-73 26 rs369385294 0.3171 -0.776 1.0 D 0.842 0.667 None gnomAD-4.0.0 1.41941E-04 None None None None N None 8.01325E-05 0 None 0 0 None 0 0 1.86499E-04 0 4.80446E-05
G/S 8855 Ig-74 26 rs752090627 0.5838 -0.346 1.0 D 0.825 0.701 0.560718424197 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
G/S 8855 Ig-74 26 rs752090627 0.5838 -0.346 1.0 D 0.825 0.701 0.560718424197 gnomAD-4.0.0 1.59163E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43312E-05 0
G/V 8855 Ig-74 26 rs767057972 0.9335 0.034 1.0 D 0.758 0.798 0.796077393333 gnomAD-2.1.1 2.14E-05 None None None None I None 0 5.67E-05 None 0 0 None 0 None 0 3.12E-05 0
G/V 8855 Ig-74 26 rs767057972 0.9335 0.034 1.0 D 0.758 0.798 0.796077393333 gnomAD-3.1.2 3.94E-05 None None None None I None 0 1.31096E-04 0 0 0 None 0 0 5.88E-05 0 0
G/V 8855 Ig-74 26 rs767057972 0.9335 0.034 1.0 D 0.758 0.798 0.796077393333 gnomAD-4.0.0 1.42543E-05 None None None None I None 1.33511E-05 8.34028E-05 None 0 0 None 0 0 1.27147E-05 0 3.20256E-05
G/E 8951 Ig-75 26 rs1192471071 0.9941 -0.51 1.0 D 0.818 0.705 0.816617097628 gnomAD-2.1.1 4.21E-06 None None None None I None 0 0 None 0 0 None 3.45E-05 None 0 0 0
G/E 8951 Ig-75 26 rs1192471071 0.9941 -0.51 1.0 D 0.818 0.705 0.816617097628 gnomAD-4.0.0 3.43499E-06 None None None None I None 0 0 None 0 0 None 0 0 0 5.87378E-05 0
G/R 8951 Ig-75 26 None 0.9834 None 1.0 D 0.809 0.755 0.874868149248 gnomAD-4.0.0 6.8717E-07 None None None None I None 0 0 None 0 0 None 0 0 9.02131E-07 0 0
G/E 9044 Ig-76 26 rs1417836268 0.9815 None 1.0 D 0.791 0.828 0.690045052197 gnomAD-4.0.0 6.84395E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9959E-07 0 0
G/R 9044 Ig-76 26 rs762328648 0.992 -0.517 1.0 D 0.792 0.874 0.771210160339 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.68E-05 0
G/R 9044 Ig-76 26 rs762328648 0.992 -0.517 1.0 D 0.792 0.874 0.771210160339 gnomAD-4.0.0 4.79077E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29706E-06 0 0
G/R 9137 Ig-77 26 rs1311310606 0.9838 -0.698 1.0 D 0.819 0.804 0.773199264404 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
G/R 9137 Ig-77 26 rs1311310606 0.9838 -0.698 1.0 D 0.819 0.804 0.773199264404 gnomAD-4.0.0 2.05269E-06 None None None None N None 2.98793E-05 0 None 0 0 None 0 0 1.79893E-06 0 0
G/E 9230 Ig-78 26 None 0.9839 None 0.999 D 0.777 0.847 0.806988583114 gnomAD-4.0.0 1.59123E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85822E-06 0 0
G/E 9326 Ig-79 26 None 0.9856 None 1.0 None 0.759 0.727 0.831791226727 gnomAD-4.0.0 6.84197E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15953E-05 0
G/V 9326 Ig-79 26 rs374592087 0.9292 0.054 1.0 None 0.727 0.76 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.86E-06 0
G/V 9326 Ig-79 26 rs374592087 0.9292 0.054 1.0 None 0.727 0.76 None gnomAD-4.0.0 6.84197E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99473E-07 0 0
G/C 9519 Ig-81 27 None 0.9311 None 1.0 None 0.711 0.713 0.903793654709 gnomAD-4.0.0 1.59123E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85802E-06 0 0
G/D 9519 Ig-81 27 rs1166241741 0.985 None 1.0 None 0.825 0.711 0.673404836468 gnomAD-4.0.0 1.59123E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85798E-06 0 0
G/E 9615 Ig-82 26 rs754640016 0.9755 None 1.0 None 0.764 0.73 0.780696550114 gnomAD-4.0.0 6.84164E-07 None None None None I None 0 2.23624E-05 None 0 0 None 0 0 0 0 0
G/R 9615 Ig-82 26 rs780834082 0.9853 -0.297 1.0 None 0.772 0.742 0.846209069967 gnomAD-2.1.1 4.01E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
G/R 9615 Ig-82 26 rs780834082 0.9853 -0.297 1.0 None 0.772 0.742 0.846209069967 gnomAD-4.0.0 1.59101E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
G/V 9615 Ig-82 26 rs754640016 0.9391 0.094 1.0 None 0.724 0.735 0.915970981023 gnomAD-2.1.1 4.01E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
G/V 9615 Ig-82 26 rs754640016 0.9391 0.094 1.0 None 0.724 0.735 0.915970981023 gnomAD-4.0.0 1.36833E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99425E-07 1.15939E-05 0
G/D 9723 Ig-83 26 rs1416686981 0.9933 -1.01 1.0 None 0.853 0.61 0.668130645813 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.31E-05 None 0 0 0
G/D 9723 Ig-83 26 rs1416686981 0.9933 -1.01 1.0 None 0.853 0.61 0.668130645813 gnomAD-4.0.0 1.5994E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.44013E-05 0
N/D 9926 Ig-84 27 None 0.845 None 0.999 None 0.71 0.396 0.137902524267 gnomAD-4.0.0 1.59676E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86402E-06 0 0
N/I 9926 Ig-84 27 rs377147236 0.7688 0.126 1.0 None 0.776 0.569 0.485705203746 gnomAD-2.1.1 1.23E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.71E-05 0
N/I 9926 Ig-84 27 rs377147236 0.7688 0.126 1.0 None 0.776 0.569 0.485705203746 gnomAD-4.0.0 3.70044E-05 None None None None N None 0 0 None 0 0 None 0 0 4.68039E-05 0 3.31719E-05
N/T 9926 Ig-84 27 rs377147236 0.633 -0.552 0.999 None 0.742 0.503 None gnomAD-2.1.1 8.17E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.81E-05 0
N/T 9926 Ig-84 27 rs377147236 0.633 -0.552 0.999 None 0.742 0.503 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/T 9926 Ig-84 27 rs377147236 0.633 -0.552 0.999 None 0.742 0.503 None gnomAD-4.0.0 6.82592E-06 None None None None N None 0 0 None 0 0 None 0 0 9.32953E-06 0 0
F/L 10103 Ig-86 26 None 0.996 None 0.999 None 0.543 0.539 0.335661160332 gnomAD-4.0.0 6.84132E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99389E-07 0 0
P/L 13712 Ig-87 29 rs1425096489 0.993 -0.237 0.993 D 0.741 0.393 0.75374075986 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
P/L 13712 Ig-87 29 rs1425096489 0.993 -0.237 0.993 D 0.741 0.393 0.75374075986 gnomAD-4.0.0 1.36869E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79921E-06 0 0
K/N 13806 Ig-88 27 rs767727056 0.9515 0.027 1.0 N 0.803 0.18 0.117506650769 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
K/N 13806 Ig-88 27 rs767727056 0.9515 0.027 1.0 N 0.803 0.18 0.117506650769 gnomAD-4.0.0 1.59306E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86079E-06 0 0
E/D 13990 Ig-90 26 None 0.5963 None 0.997 N 0.514 0.169 0.152612264143 gnomAD-4.0.0 1.36881E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79934E-06 0 0
R/G 14079 Ig-91 26 rs745926057 0.7514 -0.347 0.983 N 0.465 0.283 0.312001716656 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/G 14079 Ig-91 26 rs745926057 0.7514 -0.347 0.983 N 0.465 0.283 0.312001716656 gnomAD-4.0.0 2.05317E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.47883E-05 0
R/L 14079 Ig-91 26 rs746480872 0.8124 None 0.983 N 0.465 0.405 0.664074601257 gnomAD-4.0.0 1.36878E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31927E-05 0
R/Q 14079 Ig-91 26 None 0.3095 0.299 0.716 N 0.281 0.302 0.193865811164 gnomAD-2.1.1 3.22E-05 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 5.35E-05 0
R/Q 14079 Ig-91 26 None 0.3095 0.299 0.716 N 0.281 0.302 0.193865811164 gnomAD-4.0.0 6.84389E-05 None None None None N None 0 1.56593E-04 None 0 1.00903E-04 None 0 0 7.55703E-05 1.15964E-05 6.62932E-05
H/R 14167 Ig-92 26 None 0.3429 None 0.997 N 0.449 0.492 0.362758974969 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
H/Y 14167 Ig-92 26 None 0.2665 None 0.999 D 0.46 0.489 0.606237419447 gnomAD-4.0.0 1.59221E-06 None None None None N None 0 0 None 0 0 None 1.88274E-05 0 0 0 0
K/Q 14256 Ig-93 26 None 0.4165 None 1.0 D 0.695 0.45 0.424430313326 gnomAD-4.0.0 8.21284E-06 None None None None N None 0 0 None 0 0 None 0 0 1.07952E-05 0 0
K/R 14256 Ig-93 26 rs768083088 0.1115 0.006 0.999 N 0.657 0.366 0.575180444326 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/R 14256 Ig-93 26 rs768083088 0.1115 0.006 0.999 N 0.657 0.366 0.575180444326 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.30976E-04 0 0 0 None 0 0 0 0 0
K/R 14256 Ig-93 26 rs768083088 0.1115 0.006 0.999 N 0.657 0.366 0.575180444326 gnomAD-4.0.0 3.84531E-06 None None None None N None 0 5.08699E-05 None 0 0 None 0 0 0 0 0
R/K 14433 Ig-95 26 rs914023000 0.2905 -0.488 0.997 N 0.581 0.392 0.576114100093 gnomAD-2.1.1 8.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
R/K 14433 Ig-95 26 rs914023000 0.2905 -0.488 0.997 N 0.581 0.392 0.576114100093 gnomAD-4.0.0 5.47495E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19701E-06 0 0
H/D 14522 Ig-96 26 None 0.843 None 1.0 D 0.682 0.499 0.47432691512 gnomAD-4.0.0 6.87452E-07 None None None None N None 0 0 None 0 0 None 0 0 9.02226E-07 0 0
H/P 14522 Ig-96 26 None 0.8205 None 1.0 N 0.7 0.586 0.502878934189 gnomAD-4.0.0 4.81666E-06 None None None None N None 0 0 None 0 0 None 0 0 6.32315E-06 0 0
H/R 14522 Ig-96 26 rs374085402 0.5565 -0.665 1.0 D 0.705 0.356 None gnomAD-2.1.1 5.5E-05 None None None None N None 0 9.05E-05 None 0 4.73765E-04 None 3.44E-05 None 0 0 1.72058E-04
H/R 14522 Ig-96 26 rs374085402 0.5565 -0.665 1.0 D 0.705 0.356 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94024E-04 None 0 0 0 0 0
H/R 14522 Ig-96 26 rs374085402 0.5565 -0.665 1.0 D 0.705 0.356 None gnomAD-4.0.0 1.99282E-05 None None None None N None 0 5.07597E-05 None 0 2.70161E-04 None 0 0 8.50737E-07 0 2.57375E-04
Y/C 14789 Ig-99 25 rs397517577 0.3018 -0.099 1.0 N 0.607 0.421 0.459192005304 gnomAD-2.1.1 2.5E-05 None None None None N None 0 0 None 0 0 None 1.30753E-04 None 0 2.35E-05 0
Y/C 14789 Ig-99 25 rs397517577 0.3018 -0.099 1.0 N 0.607 0.421 0.459192005304 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
Y/C 14789 Ig-99 25 rs397517577 0.3018 -0.099 1.0 N 0.607 0.421 0.459192005304 gnomAD-4.0.0 3.47208E-05 None None None None N None 0 0 None 0 0 None 0 0 3.22217E-05 1.64727E-04 4.80723E-05
R/G 14878 Ig-100 26 rs1376059487 0.645 -0.676 0.989 N 0.488 0.299 0.310458034454 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
R/G 14878 Ig-100 26 rs1376059487 0.645 -0.676 0.989 N 0.488 0.299 0.310458034454 gnomAD-4.0.0 1.59384E-06 None None None None N None 0 2.29085E-05 None 0 0 None 0 0 0 0 0
R/K 14878 Ig-100 26 rs1456271454 0.1857 -0.155 0.37 N 0.176 0.177 0.388495093706 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/K 14878 Ig-100 26 rs1456271454 0.1857 -0.155 0.37 N 0.176 0.177 0.388495093706 gnomAD-4.0.0 6.58207E-06 None None None None N None 2.41418E-05 0 None 0 0 None 0 0 0 0 0
R/L 14967 Ig-101 26 None 0.3777 None 0.561 D 0.487 0.279 0.460526725402 gnomAD-4.0.0 1.37593E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80521E-06 0 0
R/Q 14967 Ig-101 26 rs752671402 0.1431 0.014 0.832 D 0.595 0.149 0.270889551736 gnomAD-2.1.1 5.18E-05 None None None None N None 0 0 None 0 0 None 6.94E-05 None 3.65913E-04 2.42E-05 0
R/Q 14967 Ig-101 26 rs752671402 0.1431 0.014 0.832 D 0.595 0.149 0.270889551736 gnomAD-3.1.2 4.62E-05 None None None None N None 4.85E-05 0 0 0 0 None 1.89681E-04 0 4.42E-05 0 0
R/Q 14967 Ig-101 26 rs752671402 0.1431 0.014 0.832 D 0.595 0.149 0.270889551736 gnomAD-4.0.0 3.17741E-05 None None None None N None 2.68449E-05 1.6889E-05 None 0 0 None 3.30272E-04 0 1.78612E-05 2.23639E-05 6.44538E-05
K/I 15056 Ig-102 26 None 0.517 None 1.0 D 0.733 0.662 0.732782589432 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/R 15056 Ig-102 26 None 0.1151 None 0.999 D 0.65 0.476 0.634805254685 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
K/E 15145 Ig-103 26 None 0.705 None 0.939 N 0.497 0.254 0.418095516054 gnomAD-4.0.0 1.36966E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79987E-06 0 0
T/I 15233 Ig-104 26 rs1267073931 0.332 0.038 0.876 N 0.553 0.196 0.380223377699 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14863E-04 0 None 0 0 None 0 None 0 0 0
T/I 15233 Ig-104 26 rs1267073931 0.332 0.038 0.876 N 0.553 0.196 0.380223377699 gnomAD-3.1.2 1.98E-05 None None None None N None 7.25E-05 0 0 0 0 None 0 0 0 0 0
T/I 15233 Ig-104 26 rs1267073931 0.332 0.038 0.876 N 0.553 0.196 0.380223377699 gnomAD-4.0.0 2.48085E-06 None None None None N None 4.01091E-05 0 None 0 0 None 0 0 8.48073E-07 0 0
T/N 15233 Ig-104 26 None 0.2745 None 0.111 N 0.33 0.121 0.283761946502 gnomAD-4.0.0 3.42352E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49942E-06 0 0
R/C 15327 Ig-105 26 rs367774903 0.3685 -0.132 1.0 D 0.591 0.468 None gnomAD-2.1.1 1.68987E-04 None None None None N None 0 0 None 9.74E-05 0 None 3.29E-05 None 2.40751E-04 2.99293E-04 1.41804E-04
R/C 15327 Ig-105 26 rs367774903 0.3685 -0.132 1.0 D 0.591 0.468 None gnomAD-3.1.2 1.44834E-04 None None None None N None 0 6.57E-05 0 0 0 None 2.82859E-04 0 2.65127E-04 0 0
R/C 15327 Ig-105 26 rs367774903 0.3685 -0.132 1.0 D 0.591 0.468 None gnomAD-4.0.0 1.18496E-04 None None None None N None 0 1.67218E-05 None 3.38662E-05 0 None 2.34698E-04 1.64853E-04 1.42506E-04 1.09977E-05 6.41375E-05
R/H 15327 Ig-105 26 rs374697274 0.2437 -0.824 1.0 N 0.533 0.414 None gnomAD-2.1.1 4.86E-05 None None None None N None 6.48E-05 2.91E-05 None 0 1.68843E-04 None 6.55E-05 None 0 3.58E-05 1.67168E-04
R/H 15327 Ig-105 26 rs374697274 0.2437 -0.824 1.0 N 0.533 0.414 None gnomAD-3.1.2 6.58E-05 None None None None N None 1.20715E-04 0 0 0 0 None 0 0 4.42E-05 2.07039E-04 4.78469E-04
R/H 15327 Ig-105 26 rs374697274 0.2437 -0.824 1.0 N 0.533 0.414 None gnomAD-4.0.0 1.04839E-04 None None None None N None 9.35779E-05 3.34292E-05 None 0 6.71592E-05 None 0 8.24266E-04 1.21298E-04 5.49608E-05 6.41375E-05
R/T 15416 Ig-106 26 None 0.3991 None 0.801 N 0.377 0.317 0.609094465904 gnomAD-4.0.0 2.15149E-06 None None None None N None 0 0 None 0 0 None 0 0 2.77486E-06 0 0
A/T 15593 Ig-108 26 rs1253393520 0.4316 -1.139 1.0 D 0.801 0.452 0.490908442424 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
A/T 15593 Ig-108 26 rs1253393520 0.4316 -1.139 1.0 D 0.801 0.452 0.490908442424 gnomAD-4.0.0 1.59636E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43456E-05 0
G/A 15988 Ig-109 21 rs1182070042 0.5529 -0.208 1.0 D 0.787 0.645 0.516827169674 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
G/A 15988 Ig-109 21 rs1182070042 0.5529 -0.208 1.0 D 0.787 0.645 0.516827169674 gnomAD-3.1.2 6.59E-06 None None None None I None 0 6.57E-05 0 0 0 None 0 0 0 0 0
G/A 15988 Ig-109 21 rs1182070042 0.5529 -0.208 1.0 D 0.787 0.645 0.516827169674 gnomAD-4.0.0 1.86046E-06 None None None None I None 0 1.66984E-05 None 0 0 None 0 0 0 2.19635E-05 0
G/D 15988 Ig-109 21 None 0.9895 None 1.0 D 0.859 0.739 0.618934792644 gnomAD-4.0.0 1.36924E-06 None None None None I None 2.99419E-05 0 None 0 0 None 0 0 8.99915E-07 0 0
G/R 16284 Ig-110 23 rs368527534 0.9979 -0.338 1.0 D 0.825 0.817 0.88659098148 gnomAD-2.1.1 3.23E-05 None None None None I None 0 2.91E-05 None 0 0 None 9.81E-05 None 0 3.58E-05 0
G/R 16284 Ig-110 23 rs368527534 0.9979 -0.338 1.0 D 0.825 0.817 0.88659098148 gnomAD-3.1.2 1.98E-05 None None None None I None 0 0 0 0 0 None 0 0 0 4.1425E-04 4.79846E-04
G/R 16284 Ig-110 23 rs368527534 0.9979 -0.338 1.0 D 0.825 0.817 0.88659098148 gnomAD-4.0.0 4.03166E-05 None None None None I None 0 5.01102E-05 None 3.38318E-05 0 None 1.56397E-05 0 3.73181E-05 1.20839E-04 8.01513E-05
A/T 16980 Ig-111 26 None 0.7976 None 0.955 D 0.692 0.458 0.493156425868 gnomAD-4.0.0 3.1869E-06 None None None None I None 0 0 None 0 0 None 0 0 5.72357E-06 0 0
A/V 16980 Ig-111 26 None 0.9057 None 0.977 D 0.73 0.542 0.583551733957 gnomAD-4.0.0 1.59345E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8618E-06 0 0
G/R 17273 Ig-112 23 None 0.9967 None 1.0 D 0.832 0.821 0.795030053833 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/C 17698 Ig-113 22 None 0.9793 None 1.0 D 0.705 0.699 0.801087466005 gnomAD-4.0.0 6.84435E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.6575E-05
G/D 17698 Ig-113 22 None 0.9967 None 1.0 D 0.817 0.718 0.703032555758 gnomAD-4.0.0 1.36885E-06 None None None None I None 0 0 None 0 2.52067E-05 None 0 0 8.99719E-07 0 0
G/S 17698 Ig-113 22 None 0.9284 None 1.0 D 0.785 0.713 0.632936377593 gnomAD-4.0.0 6.84435E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99714E-07 0 0
G/V 18404 Ig-115 23 rs746548796 0.9866 -0.573 1.0 D 0.784 0.696 0.793340593918 gnomAD-2.1.1 7.16E-06 None None None None I None 4.14E-05 0 None 0 0 None 3.27E-05 None 0 0 0
G/V 18404 Ig-115 23 rs746548796 0.9866 -0.573 1.0 D 0.784 0.696 0.793340593918 gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
G/V 18404 Ig-115 23 rs746548796 0.9866 -0.573 1.0 D 0.784 0.696 0.793340593918 gnomAD-4.0.0 2.56567E-06 None None None None I None 1.69382E-05 0 None 0 0 None 0 0 0 1.34102E-05 0
G/D 18710 Ig-116 23 None 0.9909 None 1.0 D 0.799 0.882 0.642270024921 gnomAD-4.0.0 1.59696E-06 None None None None I None 0 0 None 0 2.78893E-05 None 0 0 0 0 0
G/S 18710 Ig-116 23 rs1328807587 0.9159 -0.571 1.0 D 0.763 0.885 0.548358248517 gnomAD-2.1.1 4.06E-06 None None None None I None 0 2.94E-05 None 0 0 None 0 None 0 0 0
G/S 18710 Ig-116 23 rs1328807587 0.9159 -0.571 1.0 D 0.763 0.885 0.548358248517 gnomAD-4.0.0 1.37057E-06 None None None None I None 0 2.24881E-05 None 0 0 None 0 0 0 0 1.65959E-05
G/V 18710 Ig-116 23 rs748172946 0.9782 0.184 1.0 D 0.765 0.86 0.921936245945 gnomAD-2.1.1 4.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.95E-06 0
G/V 18710 Ig-116 23 rs748172946 0.9782 0.184 1.0 D 0.765 0.86 0.921936245945 gnomAD-4.0.0 1.59696E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86548E-06 0 0
G/R 19118 Ig-117 24 rs1201313907 0.9944 -0.397 1.0 D 0.807 0.701 0.801875625057 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
G/R 19118 Ig-117 24 rs1201313907 0.9944 -0.397 1.0 D 0.807 0.701 0.801875625057 gnomAD-4.0.0 1.59238E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43299E-05 0
G/D 19412 Ig-118 22 rs998581111 0.9971 None 1.0 D 0.817 0.573 0.664353351204 gnomAD-4.0.0 3.42195E-06 None None None None I None 0 0 None 0 1.26461E-04 None 0 0 0 0 0
G/S 19412 Ig-118 22 None 0.9304 None 1.0 D 0.802 0.552 0.616482784632 gnomAD-4.0.0 2.05316E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69875E-06 0 0
G/A 19812 Ig-119 23 None 0.8876 None 1.0 D 0.729 0.708 0.604058420995 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
G/R 19812 Ig-119 23 None 0.9985 None 1.0 D 0.768 0.729 0.834012836507 gnomAD-4.0.0 7.52761E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29715E-06 0 6.62691E-05
G/S 20104 Ig-120 25 rs747671998 0.9293 -0.895 1.0 D 0.841 0.649 0.640061320974 gnomAD-2.1.1 4.09E-06 None None None None I None 0 0 None 0 0 None 3.4E-05 None 0 0 0
G/S 20104 Ig-120 25 rs747671998 0.9293 -0.895 1.0 D 0.841 0.649 0.640061320974 gnomAD-4.0.0 1.3727E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.17272E-05 1.66218E-05
G/R 20502 Ig-121 24 rs773099372 0.9972 -0.5 0.999 D 0.763 0.76 0.789728907447 gnomAD-2.1.1 2.98E-05 None None None None I None 0 0 None 0 0 None 0 None 2.92255E-04 0 1.76991E-04
G/R 20502 Ig-121 24 rs773099372 0.9972 -0.5 0.999 D 0.763 0.76 0.789728907447 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 9.42E-05 0 0 0 0
G/R 20502 Ig-121 24 rs773099372 0.9972 -0.5 0.999 D 0.763 0.76 0.789728907447 gnomAD-4.0.0 2.2189E-05 None None None None I None 0 0 None 0 0 None 2.69311E-04 0 0 0 0
G/S 20502 Ig-121 24 None 0.9113 None 0.984 D 0.645 0.694 0.576774385015 gnomAD-4.0.0 1.6282E-06 None None None None I None 0 2.35671E-05 None 0 0 None 0 0 0 0 0
G/S 20795 Ig-122 27 rs761580423 0.9749 -1.144 1.0 D 0.839 0.842 0.566047931302 gnomAD-2.1.1 2.42E-05 None None None None I None 0 0 None 0 0 None 1.96592E-04 None 0 0 0
G/S 20795 Ig-122 27 rs761580423 0.9749 -1.144 1.0 D 0.839 0.842 0.566047931302 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
G/S 20795 Ig-122 27 rs761580423 0.9749 -1.144 1.0 D 0.839 0.842 0.566047931302 gnomAD-4.0.0 1.2399E-05 None None None None I None 0 0 None 0 0 None 0 0 1.69566E-06 1.86764E-04 1.60174E-05
G/E 21200 Ig-123 24 rs1313160165 0.9967 -0.901 1.0 D 0.809 0.824 0.731956435446 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
G/E 21200 Ig-123 24 rs1313160165 0.9967 -0.901 1.0 D 0.809 0.824 0.731956435446 gnomAD-4.0.0 6.37284E-06 None None None None I None 0 0 None 0 0 None 0 0 1.14449E-05 0 0
G/R 21200 Ig-123 24 None 0.996 None 1.0 D 0.81 0.834 0.81583949607 gnomAD-4.0.0 3.1865E-06 None None None None I None 0 0 None 0 0 None 1.88388E-05 0 2.8612E-06 0 0
G/E 21492 Ig-124 24 rs879135883 0.9985 None 1.0 D 0.798 0.591 None gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
G/E 21492 Ig-124 24 rs879135883 0.9985 None 1.0 D 0.798 0.591 None gnomAD-4.0.0 5.0755E-06 None None None None N None 8.74065E-05 0 None 0 0 None 0 0 0 0 0
G/R 21492 Ig-124 24 None 0.9955 None 1.0 D 0.806 0.588 0.805673472657 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
G/S 21889 Ig-125 24 None 0.9408 None 1.0 D 0.805 0.718 0.637732811552 gnomAD-4.0.0 6.84933E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00061E-07 0 0
G/V 21889 Ig-125 24 rs188110701 0.995 -0.179 1.0 D 0.807 0.746 None gnomAD-2.1.1 4.05E-06 None None None None N None 6.49E-05 0 None 0 0 None 0 None 0 0 0
G/V 21889 Ig-125 24 rs188110701 0.995 -0.179 1.0 D 0.807 0.746 None gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
G/V 21889 Ig-125 24 rs188110701 0.995 -0.179 1.0 D 0.807 0.746 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
G/R 22287 Ig-126 23 rs1268203596 0.9986 -0.581 1.0 D 0.829 0.86 0.782007766743 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
G/R 22287 Ig-126 23 rs1268203596 0.9986 -0.581 1.0 D 0.829 0.86 0.782007766743 gnomAD-4.0.0 3.4231E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49903E-06 0 0
G/S 22576 Ig-127 17 rs751016349 0.9356 -0.505 1.0 D 0.802 0.8 0.59800879648 gnomAD-2.1.1 2.42E-05 None None None None I None 0 8.72E-05 None 0 0 None 0 None 0 2.67E-05 0
G/S 22576 Ig-127 17 rs751016349 0.9356 -0.505 1.0 D 0.802 0.8 0.59800879648 gnomAD-3.1.2 4.6E-05 None None None None I None 0 1.31079E-04 0 0 0 None 0 0 7.36E-05 0 0
G/S 22576 Ig-127 17 rs751016349 0.9356 -0.505 1.0 D 0.802 0.8 0.59800879648 gnomAD-4.0.0 1.67572E-05 None None None None I None 0 8.34613E-05 None 0 0 None 0 0 1.86715E-05 0 0
G/S 22973 Ig-128 24 None 0.9571 None 1.0 D 0.812 0.801 0.554356711338 gnomAD-4.0.0 3.18959E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86252E-06 1.43369E-05 0
G/D 23370 Ig-129 26 rs1372713604 0.9948 None 1.0 D 0.837 0.82 0.647389606501 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/D 23370 Ig-129 26 rs1372713604 0.9948 None 1.0 D 0.837 0.82 0.647389606501 gnomAD-4.0.0 1.23988E-06 None None None None I None 0 0 None 0 0 None 0 0 1.69573E-06 0 0
G/D 23659 Ig-130 23 None 0.9965 None 1.0 D 0.797 0.865 0.620251207734 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/S 23659 Ig-130 23 rs376256345 0.921 -0.603 1.0 D 0.815 0.677 None gnomAD-2.1.1 4.68E-05 None None None None I None 4.16E-05 1.42304E-04 None 9.73E-05 5.24E-05 None 6.58E-05 None 0 2.37E-05 0
G/S 23659 Ig-130 23 rs376256345 0.921 -0.603 1.0 D 0.815 0.677 None gnomAD-3.1.2 5.92E-05 None None None None I None 2.41E-05 2.6202E-04 0 0 1.93648E-04 None 0 0 4.41E-05 0 0
G/S 23659 Ig-130 23 rs376256345 0.921 -0.603 1.0 D 0.815 0.677 None gnomAD-4.0.0 3.41096E-05 None None None None I None 1.33533E-05 2.17036E-04 None 3.38181E-05 2.24175E-05 None 0 0 2.71356E-05 3.2996E-05 6.41046E-05
G/A 25137 Ig-134 27 rs369755096 0.7764 -0.576 1.0 D 0.695 0.767 None gnomAD-2.1.1 2.14E-05 None None None None N None 2.48036E-04 0 None 0 0 None 0 None 0 0 0
G/A 25137 Ig-134 27 rs369755096 0.7764 -0.576 1.0 D 0.695 0.767 None gnomAD-3.1.2 7.89E-05 None None None None N None 2.89729E-04 0 0 0 0 None 0 0 0 0 0
G/A 25137 Ig-134 27 rs369755096 0.7764 -0.576 1.0 D 0.695 0.767 None gnomAD-4.0.0 1.11565E-05 None None None None N None 2.40423E-04 0 None 0 0 None 0 0 0 0 0
G/C 25536 Ig-135 23 rs764082866 0.9788 -0.537 1.0 D 0.709 0.871 0.90257942251 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
G/C 25536 Ig-135 23 rs764082866 0.9788 -0.537 1.0 D 0.709 0.871 0.90257942251 gnomAD-4.0.0 1.59382E-06 None None None None I None 0 0 None 0 0 None 0 0 2.862E-06 0 0
G/D 25536 Ig-135 23 rs1021201663 0.997 None 1.0 D 0.789 0.875 0.666654704183 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/D 25536 Ig-135 23 rs1021201663 0.997 None 1.0 D 0.789 0.875 0.666654704183 gnomAD-4.0.0 6.57895E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47115E-05 0 0
G/V 25536 Ig-135 23 rs1021201663 0.9908 None 1.0 D 0.761 0.856 0.932924188304 gnomAD-4.0.0 1.59386E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02957E-05
G/C 26618 Ig-138 25 rs778343851 0.9642 -0.524 1.0 D 0.701 0.776 0.908186575641 gnomAD-2.1.1 1.61E-05 None None None None N None 0 8.69E-05 None 0 0 None 0 None 0 0 1.65453E-04
G/C 26618 Ig-138 25 rs778343851 0.9642 -0.524 1.0 D 0.701 0.776 0.908186575641 gnomAD-4.0.0 4.77435E-06 None None None None N None 0 6.86028E-05 None 0 0 None 0 0 0 0 0
G/D 26618 Ig-138 25 None 0.996 None 1.0 D 0.843 0.757 0.676562671139 gnomAD-4.0.0 1.59144E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
G/R 26905 Ig-139 26 rs772844758 0.9948 -0.781 0.999 D 0.771 0.871 0.81387883301 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 9.95E-05 0 None 0 None 0 0 0
G/R 26905 Ig-139 26 rs772844758 0.9948 -0.781 0.999 D 0.771 0.871 0.81387883301 gnomAD-4.0.0 1.59195E-06 None None None None I None 0 0 None 4.76963E-05 0 None 0 0 0 0 0
G/S 26905 Ig-139 26 rs772844758 0.8424 -1.025 0.997 D 0.795 0.868 0.585504228005 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
G/S 26905 Ig-139 26 rs772844758 0.8424 -1.025 0.997 D 0.795 0.868 0.585504228005 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/S 26905 Ig-139 26 rs772844758 0.8424 -1.025 0.997 D 0.795 0.868 0.585504228005 gnomAD-4.0.0 6.40897E-06 None None None None I None 0 0 None 0 0 None 0 0 1.19695E-05 0 0
G/S 27701 Ig-141 26 rs1559314882 0.9357 None 1.0 D 0.826 0.695 0.643145293332 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
G/S 27701 Ig-141 26 rs1559314882 0.9357 None 1.0 D 0.826 0.695 0.643145293332 gnomAD-4.0.0 4.77453E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57677E-06 0 0
G/E 27988 Ig-142 26 rs267599033 0.9749 None 0.056 D 0.424 0.73 0.476127810785 gnomAD-4.0.0 1.59299E-06 None None None None I None 0 2.29232E-05 None 0 0 None 0 0 0 0 0
G/R 28383 Ig-143 26 rs1333175409 0.9938 -1.183 1.0 D 0.851 0.714 0.849895481816 gnomAD-2.1.1 4.03E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
G/R 28383 Ig-143 26 rs1333175409 0.9938 -1.183 1.0 D 0.851 0.714 0.849895481816 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/R 28383 Ig-143 26 rs1333175409 0.9938 -1.183 1.0 D 0.851 0.714 0.849895481816 gnomAD-4.0.0 1.20033E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
G/E 28780 Ig-144 26 None 0.996 None 1.0 D 0.794 0.646 0.752038915965 gnomAD-4.0.0 6.87028E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.16951E-05 0
G/R 28780 Ig-144 26 None 0.9949 None 1.0 D 0.791 0.66 0.841327593991 gnomAD-4.0.0 2.061E-06 None None None None I None 5.98874E-05 0 None 0 2.52118E-05 None 0 0 0 0 0
G/R 29865 Ig-147 24 None 0.9964 None 1.0 D 0.83 0.832 0.821288708293 gnomAD-4.0.0 1.37457E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79906E-06 0 0
G/S 29865 Ig-147 24 None 0.9217 None 1.0 D 0.843 0.807 0.596456784696 gnomAD-4.0.0 1.37457E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.31927E-05 0
G/V 30552 Ig-149 21 None 0.991 None 1.0 D 0.804 0.797 0.939761731016 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/A 30951 Ig-150 25 None 0.7228 None 1.0 D 0.723 0.817 0.553630913754 gnomAD-4.0.0 6.84481E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99475E-07 0 0
G/D 30951 Ig-150 25 None 0.9917 None 1.0 D 0.823 0.852 0.661789245089 gnomAD-4.0.0 6.84481E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99475E-07 0 0
G/V 30951 Ig-150 25 None 0.9838 None 1.0 D 0.788 0.843 0.80964421427 gnomAD-4.0.0 6.84481E-07 None None None None I None 0 0 None 0 0 None 0 1.7343E-04 0 0 0
G/S 31641 Ig-152 21 None 0.9198 None 1.0 D 0.811 0.834 0.577797438266 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/E 33126 Ig-156 26 rs772933494 0.9981 -2.313 1.0 D 0.822 0.721 0.737378431012 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
G/E 33126 Ig-156 26 rs772933494 0.9981 -2.313 1.0 D 0.822 0.721 0.737378431012 gnomAD-4.0.0 1.36855E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79904E-06 0 0
G/S 33222 Ig-157 20 rs926931010 0.8923 -1.894 1.0 D 0.789 0.808 None gnomAD-2.1.1 3.19E-05 None None None None N None 1.14863E-04 0 None 0 0 None 0 None 0 0 0
G/S 33222 Ig-157 20 rs926931010 0.8923 -1.894 1.0 D 0.789 0.808 None gnomAD-3.1.2 3.29E-05 None None None None N None 1.20703E-04 0 0 0 0 None 0 0 0 0 0
G/S 33222 Ig-157 20 rs926931010 0.8923 -1.894 1.0 D 0.789 0.808 None gnomAD-4.0.0 6.09004E-06 None None None None N None 1.04877E-04 0 None 0 0 None 0 0 0 0 0
G/D 33521 Ig-158 26 rs370516977 0.9983 -2.046 1.0 D 0.837 0.821 None gnomAD-2.1.1 1.07E-05 None None None None N None 4.15E-05 0 None 0 0 None 0 None 4E-05 7.84E-06 0
G/D 33521 Ig-158 26 rs370516977 0.9983 -2.046 1.0 D 0.837 0.821 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/D 33521 Ig-158 26 rs370516977 0.9983 -2.046 1.0 D 0.837 0.821 None gnomAD-4.0.0 4.33872E-06 None None None None N None 1.33494E-05 0 None 0 0 None 0 0 3.39087E-06 0 3.20349E-05
G/R 33521 Ig-158 26 rs1159933027 0.9981 None 1.0 D 0.825 0.863 0.801866974335 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
G/R 33521 Ig-158 26 rs1159933027 0.9981 None 1.0 D 0.825 0.863 0.801866974335 gnomAD-4.0.0 6.84357E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15993E-05 0
G/S 33521 Ig-158 26 rs1159933027 0.9526 -1.054 1.0 D 0.842 0.835 0.547638893815 gnomAD-2.1.1 7.16E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.57E-05 0
G/S 33521 Ig-158 26 rs1159933027 0.9526 -1.054 1.0 D 0.842 0.835 0.547638893815 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/S 33521 Ig-158 26 rs1159933027 0.9526 -1.054 1.0 D 0.842 0.835 0.547638893815 gnomAD-4.0.0 7.43783E-06 None None None None N None 0 0 None 0 0 None 0 0 1.01725E-05 0 0
G/V 33521 Ig-158 26 None 0.9962 None 1.0 D 0.791 0.802 0.777110454526 gnomAD-4.0.0 6.84351E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99583E-07 0 0
G/D 33621 Ig-159 26 None 0.9991 None 1.0 D 0.837 0.848 0.641499568738 gnomAD-4.0.0 1.59181E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
Y/H 34162 Ig-160 26 rs1439821574 0.3754 -0.6 1.0 N 0.76 0.522 0.478605750892 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
G/D 34388 Ig-162 26 rs760436734 0.9966 -1.063 1.0 D 0.855 0.892 0.659056841285 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
G/D 34388 Ig-162 26 rs760436734 0.9966 -1.063 1.0 D 0.855 0.892 0.659056841285 gnomAD-4.0.0 3.18335E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43308E-05 3.02462E-05
G/C 35154 Ig-164 26 rs1448128592 0.9585 -0.691 1.0 D 0.713 0.846 0.902614888463 gnomAD-2.1.1 4.01E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
G/C 35154 Ig-164 26 rs1448128592 0.9585 -0.691 1.0 D 0.713 0.846 0.902614888463 gnomAD-4.0.0 1.59087E-06 None None None None N None 5.65227E-05 0 None 0 0 None 0 0 0 0 0
V/I 35311 Ig-165 26 None 0.0712 None None N 0.184 0.074 0.0920862733494 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 3.66327E-05
G/E 35445 Ig-166 26 None 0.8202 None 1.0 D 0.82 0.762 0.626065636982 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
G/D 35632 Ig-167 26 rs1210557316 0.2851 None 0.006 N 0.247 0.437 0.253726318573 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
G/D 35632 Ig-167 26 rs1210557316 0.2851 None 0.006 N 0.247 0.437 0.253726318573 gnomAD-4.0.0 1.23928E-06 None None None None I None 0 0 None 0 0 None 0 0 8.47541E-07 1.09786E-05 0
G/V 35632 Ig-167 26 rs1210557316 0.5191 None 0.928 N 0.629 0.659 0.820686710369 gnomAD-4.0.0 6.84146E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99399E-07 0 0
G/A 35727 Ig-168 26 None 0.502 None 1.0 D 0.742 0.76 0.59007929581 gnomAD-4.0.0 1.59475E-06 None None None None I None 0 0 None 0 2.77593E-05 None 0 0 0 0 0
G/S 35922 Ig-169 26 None 0.6848 None 1.0 D 0.825 0.661 0.580120749226 gnomAD-4.0.0 1.20032E-06 None None None -1.543(OBSL1) -0.986(OBSCN) N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.