Structural position:

  • Domain Type: Ig
  • Aligned Position: 45
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand C

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
E/K 36 Ig-1 31 rs2094110497 0.2338 None 0.996 N 0.657 0.517 0.488407942198 gnomAD-4.0.0 1.59079E-06 None None None -0.214(TCAP) N None 0 2.28666E-05 None 0 0 None 0 0 0 0 0
V/G 134 Ig-2 31 rs754896104 0.4603 -0.78 0.993 N 0.685 0.598 0.821069369337 gnomAD-2.1.1 7.96E-06 None None None -0.727(TCAP) N None 0 0 None 0 1.08885E-04 None 0 None 0 0 0
V/G 134 Ig-2 31 rs754896104 0.4603 -0.78 0.993 N 0.685 0.598 0.821069369337 gnomAD-4.0.0 2.73632E-06 None None None -0.727(TCAP) N None 0 0 None 0 1.00781E-04 None 0 0 0 0 0
V/L 134 Ig-2 31 None 0.2606 None 0.003 N 0.189 0.247 0.245660935333 gnomAD-4.0.0 6.84088E-07 None None None -0.779(TCAP) N None 0 0 None 0 2.5194E-05 None 0 0 0 0 0
H/L 1112 Ig-4 31 rs540783675 0.3094 0.675 1.0 N 0.718 0.584 0.682004838343 gnomAD-2.1.1 3.98E-06 None None None None N None 6.15E-05 0 None 0 0 None 0 None 0 0 0
H/L 1112 Ig-4 31 rs540783675 0.3094 0.675 1.0 N 0.718 0.584 0.682004838343 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
H/L 1112 Ig-4 31 rs540783675 0.3094 0.675 1.0 N 0.718 0.584 0.682004838343 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
H/L 1112 Ig-4 31 rs540783675 0.3094 0.675 1.0 N 0.718 0.584 0.682004838343 gnomAD-4.0.0 6.56797E-06 None None None None N None 2.40628E-05 0 None 0 0 None 0 0 0 0 0
H/R 1112 Ig-4 31 None 0.4422 None 1.0 N 0.663 0.499 0.294918367191 gnomAD-4.0.0 1.59051E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
K/E 1321 Ig-5 31 rs1204400340 0.7727 0.441 0.999 N 0.662 0.505 0.435152311215 gnomAD-2.1.1 4.01E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.87E-06 0
K/E 1321 Ig-5 31 rs1204400340 0.7727 0.441 0.999 N 0.662 0.505 0.435152311215 gnomAD-4.0.0 2.40103E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62544E-06 0 0
E/D 1487 Ig-6 31 None 0.2266 None None N 0.186 0.096 0.0954503805726 gnomAD-4.0.0 6.84115E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15939E-05 0
E/G 1487 Ig-6 31 rs1561308394 0.6071 None 0.324 D 0.543 0.495 0.518858945281 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 5.45E-05 None 0 None 0 0 0
E/G 1487 Ig-6 31 rs1561308394 0.6071 None 0.324 D 0.543 0.495 0.518858945281 gnomAD-4.0.0 1.59073E-06 None None None None I None 0 0 None 0 2.77331E-05 None 0 0 0 0 0
D/E 1586 Ig-7 31 None 0.5884 None 1.0 N 0.509 0.291 0.402755899245 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/V 1586 Ig-7 31 rs2092325791 0.8134 None 1.0 N 0.811 0.696 0.597483089494 gnomAD-4.0.0 2.05227E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 4.96738E-05
K/N 1871 Ig-9 31 None 0.9065 None 0.999 N 0.672 0.239 0.20549828249 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
E/K 2108 Ig-10 31 rs762999586 0.2707 0.109 1.0 N 0.635 0.502 None gnomAD-2.1.1 2.84E-05 None None None None N None 0 8.48E-05 None 0 0 None 0 None 0 3.89E-05 0
E/K 2108 Ig-10 31 rs762999586 0.2707 0.109 1.0 N 0.635 0.502 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 4.41E-05 0 0
E/K 2108 Ig-10 31 rs762999586 0.2707 0.109 1.0 N 0.635 0.502 None gnomAD-4.0.0 2.29271E-05 None None None None N None 0 1.0005E-04 None 0 0 None 1.56211E-05 1.64366E-04 2.03396E-05 1.09796E-05 6.40225E-05
K/E 2204 Ig-11 31 rs1466089767 0.1964 None 0.997 N 0.639 0.501 0.378847511475 gnomAD-4.0.0 2.05233E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69795E-06 0 0
K/N 2204 Ig-11 31 rs1060500448 0.3728 0.015 0.999 N 0.747 0.26 0.243398259712 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
K/N 2204 Ig-11 31 rs1060500448 0.3728 0.015 0.999 N 0.747 0.26 0.243398259712 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
K/N 2204 Ig-11 31 rs1060500448 0.3728 0.015 0.999 N 0.747 0.26 0.243398259712 gnomAD-4.0.0 7.68421E-06 None None None None N None 0 1.01688E-04 None 0 0 None 0 0 0 0 0
E/G 2385 Ig-13 30 rs1409894500 0.1658 -0.025 1.0 D 0.683 0.716 0.70889124218 gnomAD-2.1.1 3.98E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/G 2385 Ig-13 30 rs1409894500 0.1658 -0.025 1.0 D 0.683 0.716 0.70889124218 gnomAD-4.0.0 1.59058E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
E/K 2385 Ig-13 30 rs762331136 0.1197 0.746 0.999 N 0.632 0.453 0.57058010678 gnomAD-2.1.1 3.98E-06 None None None None I None 0 0 None 0 5.44E-05 None 0 None 0 0 0
E/K 2385 Ig-13 30 rs762331136 0.1197 0.746 0.999 N 0.632 0.453 0.57058010678 gnomAD-4.0.0 8.40225E-06 None None None None I None 0 0 None 0 0 None 0 0 9.18751E-06 0 0
E/V 2385 Ig-13 30 rs1409894500 0.2174 None 1.0 N 0.754 0.685 0.727170900192 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/V 2385 Ig-13 30 rs1409894500 0.2174 None 1.0 N 0.754 0.685 0.727170900192 gnomAD-4.0.0 6.57022E-06 None None None None I None 2.4122E-05 0 None 0 0 None 0 0 0 0 0
D/E 2562 Ig-15 30 None 0.275 None 0.767 N 0.3 0.194 0.304760801415 gnomAD-4.0.0 1.59088E-06 None None None None N None 0 2.2876E-05 None 0 0 None 0 0 0 0 0
D/G 2562 Ig-15 30 rs2091799786 0.3552 None 0.998 D 0.725 0.754 0.423954403188 gnomAD-4.0.0 1.20033E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
K/E 2649 Ig-16 29 rs769037510 0.067 0.197 None N 0.107 0.096 0.194818534648 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.8E-06 0
K/R 2649 Ig-16 29 rs745433704 0.0943 0.227 0.012 N 0.319 0.11 0.381746406553 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 5.45E-05 None 0 None 0 0 0
K/R 2649 Ig-16 29 rs745433704 0.0943 0.227 0.012 N 0.319 0.11 0.381746406553 gnomAD-4.0.0 4.78879E-06 None None None None N None 0 0 None 0 5.04134E-05 None 0 0 4.4967E-06 0 0
G/R 2737 Ig-17 31 rs2091316811 0.634 None 1.0 D 0.783 0.556 0.811776346281 gnomAD-4.0.0 1.59051E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
G/V 2737 Ig-17 31 rs1308651047 0.4472 0.974 1.0 D 0.812 0.552 0.884275959959 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
G/V 2737 Ig-17 31 rs1308651047 0.4472 0.974 1.0 D 0.812 0.552 0.884275959959 gnomAD-4.0.0 3.181E-06 None None None None N None 0 4.57289E-05 None 0 0 None 0 0 0 0 0
P/R 2911 Ig-19 30 rs770166191 0.8386 0.123 1.0 D 0.821 0.747 0.768786753902 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
P/R 2911 Ig-19 30 rs770166191 0.8386 0.123 1.0 D 0.821 0.747 0.768786753902 gnomAD-4.0.0 1.59049E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85651E-06 0 0
S/T 2998 Ig-20 30 rs374490159 0.0664 -0.055 None N 0.147 0.145 None gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.8E-06 0
S/T 2998 Ig-20 30 rs374490159 0.0664 -0.055 None N 0.147 0.145 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/T 2998 Ig-20 30 rs374490159 0.0664 -0.055 None N 0.147 0.145 None gnomAD-4.0.0 1.85877E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69489E-06 1.09791E-05 0
S/Y 2998 Ig-20 30 None 0.2768 None 0.879 D 0.685 0.467 0.682911096811 gnomAD-4.0.0 1.59066E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85657E-06 0 0
D/Y 3176 Ig-22 30 None 0.5556 None 0.997 N 0.743 0.642 0.73228921728 gnomAD-4.0.0 1.59065E-06 None None None None N None 0 0 None 0 0 None 1.88232E-05 0 0 0 0
K/T 3269 Ig-23 31 None 0.181 None 0.134 N 0.297 0.414 0.299427821978 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/E 3374 Ig-24 30 rs770029258 0.1653 -0.77 0.103 N 0.411 0.244 0.276898752692 gnomAD-2.1.1 4E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
K/E 3374 Ig-24 30 rs770029258 0.1653 -0.77 0.103 N 0.411 0.244 0.276898752692 gnomAD-4.0.0 6.15742E-06 None None None None N None 0 2.23634E-05 None 0 0 None 0 0 7.19488E-06 0 0
E/D 3495 Ig-25 31 None 0.1744 None None None None 0.101 None gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
D/V 3690 Ig-26 31 rs1574368049 0.242 None None None None 0.143 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/Y 3690 Ig-26 31 rs972676424 0.2168 None None None None 0.047 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
K/E 3850 Ig-27 31 None 0.1008 None 0.012 N 0.442 0.075 None gnomAD-4.0.0 1.59128E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8584E-06 0 0
K/R 3850 Ig-27 31 rs763263943 0.0834 0.004 None N 0.25 0.08 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/R 3850 Ig-27 31 rs763263943 0.0834 0.004 None N 0.25 0.08 None gnomAD-4.0.0 1.59128E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
T/A 3968 Ig-28 31 rs540085214 0.0714 -0.266 0.003 N 0.084 0.072 None gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
T/A 3968 Ig-28 31 rs540085214 0.0714 -0.266 0.003 N 0.084 0.072 None gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 0 None 0 0 5.88E-05 0 0
T/A 3968 Ig-28 31 rs540085214 0.0714 -0.266 0.003 N 0.084 0.072 None gnomAD-4.0.0 8.67553E-06 None None None None I None 0 0 None 0 0 None 0 0 1.18663E-05 0 0
T/I 3968 Ig-28 31 rs1416083040 0.1236 0.295 0.351 D 0.505 0.189 None gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
T/I 3968 Ig-28 31 rs1416083040 0.1236 0.295 0.351 D 0.505 0.189 None gnomAD-4.0.0 1.59107E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85788E-06 0 0
E/D 4634 Ig-29 29 rs1408608016 0.1547 -0.516 0.117 N 0.42 0.056 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
E/D 4634 Ig-29 29 rs1408608016 0.1547 -0.516 0.117 N 0.42 0.056 None gnomAD-4.0.0 4.10548E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39686E-06 0 0
R/L 4730 Ig-30 31 None 0.3129 None 0.82 N 0.516 0.356 0.468586609112 gnomAD-4.0.0 6.84332E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9953E-07 0 0
R/Q 4730 Ig-30 31 rs202017278 0.1234 0.176 0.91 N 0.527 0.263 None gnomAD-2.1.1 2.86E-05 None None None None I None 1.24069E-04 0 None 0 0 None 6.54E-05 None 0 2.35E-05 0
R/Q 4730 Ig-30 31 rs202017278 0.1234 0.176 0.91 N 0.527 0.263 None gnomAD-3.1.2 3.94E-05 None None None None I None 1.2068E-04 0 0 0 0 None 0 0 1.47E-05 0 0
R/Q 4730 Ig-30 31 rs202017278 0.1234 0.176 0.91 N 0.527 0.263 None gnomAD-4.0.0 8.11942E-05 None None None None I None 9.34554E-05 0 None 0 0 None 0 1.64474E-04 9.66334E-05 5.49185E-05 6.40656E-05
R/W 4730 Ig-30 31 rs749719834 0.22 -0.441 0.999 N 0.435 0.408 0.539478914628 gnomAD-2.1.1 1.61E-05 None None None None I None 1.29282E-04 0 None 0 0 None 0 None 0 1.78E-05 0
R/W 4730 Ig-30 31 rs749719834 0.22 -0.441 0.999 N 0.435 0.408 0.539478914628 gnomAD-3.1.2 1.97E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
R/W 4730 Ig-30 31 rs749719834 0.22 -0.441 0.999 N 0.435 0.408 0.539478914628 gnomAD-4.0.0 8.67716E-06 None None None None I None 4.00491E-05 0 None 0 0 None 0 0 9.32428E-06 0 0
E/A 4825 Ig-31 31 rs769228664 0.2651 -0.262 0.006 N 0.241 0.246 0.353548585375 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/A 4825 Ig-31 31 rs769228664 0.2651 -0.262 0.006 N 0.241 0.246 0.353548585375 gnomAD-4.0.0 6.8421E-07 None None None None I None 0 2.23624E-05 None 0 0 None 0 0 0 0 0
E/V 4825 Ig-31 31 None 0.4143 None 0.324 N 0.55 0.303 0.556811950826 gnomAD-4.0.0 2.05263E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.31873E-05 1.65656E-05
T/I 4918 Ig-32 31 rs749179515 0.1251 0.044 0.97 D 0.669 0.298 0.576674430037 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66003E-04
T/I 4918 Ig-32 31 rs749179515 0.1251 0.044 0.97 D 0.669 0.298 0.576674430037 gnomAD-4.0.0 4.77407E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71615E-06 0 3.02462E-05
Q/H 5012 Ig-33 32 None 0.1518 None 0.002 N 0.151 0.36 0.213573922156 gnomAD-4.0.0 1.5922E-06 None None None None I None 0 0 None 0 2.78102E-05 None 0 0 0 0 0
E/A 5105 Ig-34 31 rs1374129248 0.2835 -0.324 0.977 D 0.689 0.544 0.534572409765 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
E/A 5105 Ig-34 31 rs1374129248 0.2835 -0.324 0.977 D 0.689 0.544 0.534572409765 gnomAD-4.0.0 1.59167E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85892E-06 0 0
S/F 5198 Ig-35 31 None 0.1314 None None D 0.365 0.339 0.532359089423 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/G 5387 Ig-37 31 rs371501460 0.1328 -0.16 0.425 N 0.447 0.33 0.492542987314 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 2.87687E-04 0 0
R/G 5387 Ig-37 31 rs371501460 0.1328 -0.16 0.425 N 0.447 0.33 0.492542987314 gnomAD-4.0.0 1.36867E-06 None None None None I None 0 0 None 0 0 None 3.74728E-05 0 0 0 0
R/T 5387 Ig-37 31 rs748155563 0.0829 0.286 0.003 N 0.189 0.292 0.340273420219 gnomAD-2.1.1 3.22E-05 None None None None I None 0 2.03488E-04 None 0 5.61E-05 None 0 None 0 0 0
R/T 5387 Ig-37 31 rs748155563 0.0829 0.286 0.003 N 0.189 0.292 0.340273420219 gnomAD-4.0.0 6.04941E-05 None None None None I None 0 2.05997E-04 None 0 7.78556E-04 None 0 0 0 0 3.02608E-05
T/K 5480 Ig-38 31 rs753485630 0.1728 -0.304 0.006 N 0.235 0.322 0.373173300195 gnomAD-2.1.1 4.84E-05 None None None None I None 0 0 None 0 6.16385E-04 None 0 None 0 8.92E-06 0
T/K 5480 Ig-38 31 rs753485630 0.1728 -0.304 0.006 N 0.235 0.322 0.373173300195 gnomAD-4.0.0 1.27344E-05 None None None None I None 0 0 None 0 1.66713E-04 None 0 0 2.85871E-06 0 3.02535E-05
T/R 5480 Ig-38 31 None 0.1415 None 0.473 N 0.541 0.328 0.487208542674 gnomAD-4.0.0 1.59179E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85871E-06 0 0
T/A 5760 Ig-41 31 None 0.0808 None 0.004 D 0.163 0.135 0.231231049324 gnomAD-4.0.0 1.59168E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8586E-06 0 0
T/M 5760 Ig-41 31 rs770310501 0.0857 0.047 0.328 D 0.415 0.269 0.579270068135 gnomAD-2.1.1 1.79E-05 None None None None I None 1.24008E-04 2.83E-05 None 0 0 None 3.27E-05 None 0 0 0
T/M 5760 Ig-41 31 rs770310501 0.0857 0.047 0.328 D 0.415 0.269 0.579270068135 gnomAD-3.1.2 1.31E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
T/M 5760 Ig-41 31 rs770310501 0.0857 0.047 0.328 D 0.415 0.269 0.579270068135 gnomAD-4.0.0 1.11561E-05 None None None None I None 8.01089E-05 5.004E-05 None 0 0 None 0 3.29056E-04 0 1.09803E-05 9.60922E-05
T/I 5853 Ig-42 31 rs2154308873 0.1093 None None N 0.315 0.155 0.277730125212 gnomAD-4.0.0 4.1054E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39702E-06 0 0
S/G 5949 Ig-43 31 rs368275231 0.1322 -0.598 0.625 N 0.416 0.33 None gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.97E-06 0
S/G 5949 Ig-43 31 rs368275231 0.1322 -0.598 0.625 N 0.416 0.33 None gnomAD-4.0.0 1.59159E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85889E-06 0 0
S/N 5949 Ig-43 31 rs1578154475 0.1224 None 0.051 N 0.183 0.121 0.215869574891 gnomAD-4.0.0 1.36855E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99539E-07 0 1.65673E-05
T/I 6042 Ig-44 31 None 0.1108 None 0.007 N 0.269 0.351 0.388174495139 gnomAD-4.0.0 6.84621E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9975E-07 0 0
R/Q 6136 Ig-45 32 rs117551279 0.0683 0.2 None N 0.164 0.076 None gnomAD-2.1.1 4.53549E-04 None None None None I None 0 5.67E-05 None 0 5.65553E-03 None 3.59501E-04 None 0 7.81E-06 4.20994E-04
R/Q 6136 Ig-45 32 rs117551279 0.0683 0.2 None N 0.164 0.076 None gnomAD-3.1.2 2.03813E-04 None None None None I None 0 1.31079E-04 0 0 5.61145E-03 None 0 0 0 0 0
R/Q 6136 Ig-45 32 rs117551279 0.0683 0.2 None N 0.164 0.076 None 1000 genomes 1.19808E-03 None None None None I None 0 0 None None 6E-03 0 None None None 0 None
R/Q 6136 Ig-45 32 rs117551279 0.0683 0.2 None N 0.164 0.076 None gnomAD-4.0.0 1.26422E-04 None None None None I None 0 1.16733E-04 None 0 3.14648E-03 None 0 1.6518E-04 5.08589E-06 2.96423E-04 3.52135E-04
E/D 6229 Ig-46 31 rs376583582 0.1297 None 0.22 N 0.581 0.115 0.258779203287 gnomAD-3.1.2 1.31E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
E/D 6229 Ig-46 31 rs376583582 0.1297 None 0.22 N 0.581 0.115 0.258779203287 gnomAD-4.0.0 3.84422E-06 None None None None I None 5.07546E-05 0 None 0 0 None 0 0 0 0 0
E/G 6229 Ig-46 31 None 0.1819 None 0.22 N 0.602 0.468 0.501810158561 gnomAD-4.0.0 1.36858E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.31367E-05
S/F 6322 Ig-47 31 None 0.1394 None 0.001 D 0.351 0.369 0.435043484731 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/E 6415 Ig-48 31 rs1236523365 0.1949 0.447 0.042 N 0.383 0.15 0.223847106136 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
K/E 6415 Ig-48 31 rs1236523365 0.1949 0.447 0.042 N 0.383 0.15 0.223847106136 gnomAD-4.0.0 1.59233E-06 None None None None N None 0 2.28948E-05 None 0 0 None 0 0 0 0 0
K/N 6415 Ig-48 31 None 0.3279 None 0.175 N 0.373 0.181 0.227260227426 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/R 6415 Ig-48 31 rs775494513 0.078 -0.01 None N 0.13 0.111 0.21279746466 gnomAD-2.1.1 8.06E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 8.91E-06 0
K/R 6415 Ig-48 31 rs775494513 0.078 -0.01 None N 0.13 0.111 0.21279746466 gnomAD-4.0.0 2.73757E-06 None None None None N None 0 2.23884E-05 None 0 0 None 0 0 2.69883E-06 0 0
R/K 6698 Ig-51 32 None 0.0808 None None N 0.137 0.093 0.176091768786 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
F/L 6884 Ig-53 31 None 0.3663 None 0.001 N 0.208 0.056 0.270447802918 gnomAD-4.0.0 1.59276E-06 None None None None N None 5.66701E-05 0 None 0 0 None 0 0 0 0 0
S/L 7074 Ig-55 31 rs1456194529 0.1335 0.195 0.811 D 0.545 0.292 0.738737919071 gnomAD-2.1.1 3.18E-05 None None None None I None 1.14705E-04 0 None 0 0 None 0 None 0 0 0
S/L 7074 Ig-55 31 rs1456194529 0.1335 0.195 0.811 D 0.545 0.292 0.738737919071 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/L 7074 Ig-55 31 rs1456194529 0.1335 0.195 0.811 D 0.545 0.292 0.738737919071 gnomAD-4.0.0 6.57125E-06 None None None None I None 2.41138E-05 0 None 0 0 None 0 0 0 0 0
S/F 7260 Ig-57 31 rs187925021 0.1083 None 0.029 N 0.548 0.226 0.595842844361 gnomAD-4.0.0 6.84306E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99551E-07 0 0
S/Y 7260 Ig-57 31 rs187925021 0.1089 -0.46 None N 0.335 0.222 None gnomAD-2.1.1 3.61452E-03 None None None None I None 2.39848E-03 1.13372E-03 None 1.74452E-03 5.13E-05 None 2.71728E-02 None 4E-05 3.69485E-04 1.83305E-03
S/Y 7260 Ig-57 31 rs187925021 0.1089 -0.46 None N 0.335 0.222 None gnomAD-3.1.2 2.01812E-03 None None None None I None 2.58192E-03 1.5076E-03 0 1.72911E-03 0 None 0 9.49367E-03 3.82297E-04 2.92046E-02 4.77555E-04
S/Y 7260 Ig-57 31 rs187925021 0.1089 -0.46 None N 0.335 0.222 None 1000 genomes 8.1869E-03 None None None None I None 1.5E-03 2.9E-03 None None 0 1E-03 None None None 3.68E-02 None
S/Y 7260 Ig-57 31 rs187925021 0.1089 -0.46 None N 0.335 0.222 None gnomAD-4.0.0 1.98565E-03 None None None None I None 2.5062E-03 1.18381E-03 None 1.58859E-03 4.45971E-05 None 0 1.98085E-03 2.20401E-04 2.69249E-02 2.75394E-03
T/R 7353 Ig-58 31 None 0.1143 None 0.669 N 0.448 0.259 0.647989276156 gnomAD-4.0.0 1.59249E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86013E-06 0 0
Q/L 7449 Ig-59 31 rs1269849836 0.1293 0.476 0.103 N 0.289 0.289 0.506432333661 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
Q/L 7449 Ig-59 31 rs1269849836 0.1293 0.476 0.103 N 0.289 0.289 0.506432333661 gnomAD-4.0.0 1.59197E-06 None None None None I None 0 2.28718E-05 None 0 0 None 0 0 0 0 0
R/Q 7545 Ig-60 31 rs72648969 0.0931 0.213 0.91 N 0.453 0.212 None gnomAD-2.1.1 2.11743E-03 None None None None I None 6.61978E-04 6.22524E-04 None 1.47998E-02 0 None 8.83508E-04 None 4.80577E-04 2.70996E-03 2.24909E-03
R/Q 7545 Ig-60 31 rs72648969 0.0931 0.213 0.91 N 0.453 0.212 None gnomAD-3.1.2 1.90634E-03 None None None None I None 5.30939E-04 7.86164E-04 0 1.12392E-02 0 None 1.88395E-04 0 3E-03 1.44867E-03 1.91022E-03
R/Q 7545 Ig-60 31 rs72648969 0.0931 0.213 0.91 N 0.453 0.212 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
R/Q 7545 Ig-60 31 rs72648969 0.0931 0.213 0.91 N 0.453 0.212 None gnomAD-4.0.0 3.03338E-03 None None None None I None 5.19972E-04 6.50065E-04 None 1.39941E-02 2.22906E-05 None 6.40585E-04 0 3.39123E-03 1.31877E-03 3.84246E-03
K/I 7639 Ig-61 32 rs1413635050 0.2277 0.756 0.3 N 0.623 0.249 None gnomAD-2.1.1 3.19E-05 None None None None I None 1.14732E-04 0 None 0 0 None 0 None 0 0 0
K/I 7639 Ig-61 32 rs1413635050 0.2277 0.756 0.3 N 0.623 0.249 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/I 7639 Ig-61 32 rs1413635050 0.2277 0.756 0.3 N 0.623 0.249 None gnomAD-4.0.0 1.05378E-05 None None None None I None 1.33486E-05 0 None 0 0 None 0 0 1.27181E-05 0 1.60195E-05
S/Y 7825 Ig-63 31 None 0.344 None 0.986 D 0.773 0.58 0.822358949125 gnomAD-4.0.0 1.59147E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85868E-06 0 0
S/A 7919 Ig-64 31 rs77183835 0.0769 None 0.019 N 0.213 0.081 0.187945064343 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/A 7919 Ig-64 31 rs77183835 0.0769 None 0.019 N 0.213 0.081 0.187945064343 gnomAD-4.0.0 6.84249E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15937E-05 0
S/P 7919 Ig-64 31 None 0.4773 None 0.301 N 0.456 0.389 0.251639045875 gnomAD-4.0.0 1.3685E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79905E-06 0 0
K/E 8108 Ig-66 31 rs776437978 0.1168 0.473 0.062 N 0.447 0.129 None gnomAD-2.1.1 1.21E-05 None None None None I None 1.94124E-04 0 None 0 0 None 0 None 0 0 0
K/E 8108 Ig-66 31 rs776437978 0.1168 0.473 0.062 N 0.447 0.129 None gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
K/E 8108 Ig-66 31 rs776437978 0.1168 0.473 0.062 N 0.447 0.129 None gnomAD-4.0.0 4.33856E-06 None None None None I None 6.67913E-05 0 None 0 0 None 0 0 8.4768E-07 1.09818E-05 0
K/N 8108 Ig-66 31 None 0.2595 None None N 0.225 0.138 0.207176502487 gnomAD-4.0.0 6.8427E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99504E-07 0 0
S/P 8201 Ig-67 31 rs1397176546 0.642 -0.071 0.662 N 0.465 0.394 0.337621943819 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
R/G 8294 Ig-68 31 rs72648982 0.2614 -0.125 0.153 N 0.552 0.182 None gnomAD-2.1.1 2.17258E-02 None None None None I None 5.83368E-03 1.12633E-02 None 5.20309E-02 0 None 1.77859E-02 None 1.87732E-02 2.9633E-02 2.76134E-02
R/G 8294 Ig-68 31 rs72648982 0.2614 -0.125 0.153 N 0.552 0.182 None gnomAD-3.1.2 2.06025E-02 None None None None I None 5.4298E-03 2.14772E-02 3.94737E-02 5.07205E-02 1.92604E-04 None 1.66604E-02 3.48101E-02 2.98018E-02 1.82119E-02 3.15186E-02
R/G 8294 Ig-68 31 rs72648982 0.2614 -0.125 0.153 N 0.552 0.182 None 1000 genomes 1.21805E-02 None None None None I None 2.3E-03 1.3E-02 None None 1E-03 2.78E-02 None None None 2.04E-02 None
R/G 8294 Ig-68 31 rs72648982 0.2614 -0.125 0.153 N 0.552 0.182 None gnomAD-4.0.0 2.73513E-02 None None None None I None 5.43855E-03 1.49485E-02 None 5.41326E-02 1.11428E-04 None 1.91762E-02 5.18494E-02 3.05717E-02 1.88524E-02 2.95097E-02
Q/H 8390 Ig-69 31 None 0.1481 None 0.871 N 0.403 0.224 0.28798054836 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
Q/L 8390 Ig-69 31 None 0.1101 None 0.164 N 0.35 0.237 0.421550847248 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/R 8580 Ig-71 32 None 0.0754 None None N 0.134 0.103 0.267299060538 gnomAD-4.0.0 1.59385E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43674E-05 0
H/Q 8673 Ig-72 31 rs370266918 0.0736 0.375 None N 0.055 0.107 0.0482279557977 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.65618E-04
H/Q 8673 Ig-72 31 rs370266918 0.0736 0.375 None N 0.055 0.107 0.0482279557977 gnomAD-4.0.0 1.36848E-06 None None None None I None 0 0 None 0 0 None 0 1.73491E-04 8.99522E-07 0 0
S/L 8766 Ig-73 31 rs1368458893 0.1051 0.385 0.044 N 0.339 0.313 0.593771126905 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/L 8766 Ig-73 31 rs1368458893 0.1051 0.385 0.044 N 0.339 0.313 0.593771126905 gnomAD-4.0.0 1.5918E-06 None None None None N None 0 2.28739E-05 None 0 0 None 0 0 0 0 0
S/G 8860 Ig-74 31 None 0.0979 None 0.014 N 0.291 0.173 0.240491677333 gnomAD-4.0.0 1.59163E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85871E-06 0 0
S/N 8860 Ig-74 31 rs1240256366 0.0829 None 0.007 N 0.321 0.087 0.110078149338 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
S/N 8860 Ig-74 31 rs1240256366 0.0829 None 0.007 N 0.321 0.087 0.110078149338 gnomAD-4.0.0 1.97184E-05 None None None None N None 7.23903E-05 0 None 0 0 None 0 0 0 0 0
S/F 8956 Ig-75 31 rs759580470 0.1522 -0.824 0.006 D 0.307 0.291 0.576973211123 gnomAD-2.1.1 4.09E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.05E-06 0
S/F 8956 Ig-75 31 rs759580470 0.1522 -0.824 0.006 D 0.307 0.291 0.576973211123 gnomAD-4.0.0 1.59735E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86822E-06 0 0
S/G 9049 Ig-76 31 None 0.0941 None 0.007 N 0.231 0.222 0.301122078929 gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
S/L 9142 Ig-77 31 rs781609380 0.0676 0.083 0.009 D 0.309 0.212 0.21737058555 gnomAD-2.1.1 8.03E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
S/L 9142 Ig-77 31 rs781609380 0.0676 0.083 0.009 D 0.309 0.212 0.21737058555 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 4.78011E-04
S/L 9142 Ig-77 31 rs781609380 0.0676 0.083 0.009 D 0.309 0.212 0.21737058555 gnomAD-4.0.0 1.17748E-05 None None None None N None 0 0 None 0 0 None 0 0 1.18666E-05 4.39184E-05 1.60113E-05
G/V 9235 Ig-78 31 None 0.0734 None None N 0.381 0.153 0.187945064343 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
S/A 9331 Ig-79 31 None 0.0724 None 0.019 None 0.179 0.1 0.1749357433 gnomAD-4.0.0 1.36836E-06 None None None None I None 2.98757E-05 0 None 0 0 None 0 0 8.99457E-07 0 0
K/N 9427 Ig-80 31 rs1207669528 0.45 0.351 0.968 None 0.581 0.23 0.126345400529 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/N 9427 Ig-80 31 rs1207669528 0.45 0.351 0.968 None 0.581 0.23 0.126345400529 gnomAD-4.0.0 6.84161E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99425E-07 0 0
R/K 9620 Ig-82 31 None 0.1326 None 0.028 None 0.147 0.126 0.223847106136 gnomAD-4.0.0 1.59104E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85783E-06 0 0
N/D 9728 Ig-83 31 rs794729400 0.321 0.612 0.505 None 0.518 0.278 0.246773566709 gnomAD-2.1.1 1.43E-05 None None None None I None 0 0 None 0 0 None 0 None 0 3.12E-05 0
N/D 9728 Ig-83 31 rs794729400 0.321 0.612 0.505 None 0.518 0.278 0.246773566709 gnomAD-3.1.2 3.94E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 5.88E-05 0 0
N/D 9728 Ig-83 31 rs794729400 0.321 0.612 0.505 None 0.518 0.278 0.246773566709 gnomAD-4.0.0 1.61162E-05 None None None None I None 2.67037E-05 1.66739E-05 None 0 0 None 0 0 1.86526E-05 1.09885E-05 0
N/S 9728 Ig-83 31 rs374981132 0.1165 0.064 0.001 None 0.175 0.11 None gnomAD-2.1.1 3.62E-05 None None None None I None 0 0 None 0 0 None 0 None 9.3E-05 6.2E-05 0
N/S 9728 Ig-83 31 rs374981132 0.1165 0.064 0.001 None 0.175 0.11 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/S 9728 Ig-83 31 rs374981132 0.1165 0.064 0.001 None 0.175 0.11 None gnomAD-4.0.0 2.04544E-05 None None None None I None 0 0 None 3.37906E-05 0 None 1.56211E-05 0 2.54347E-05 0 1.60102E-05
N/Y 9728 Ig-83 31 rs794729400 0.3515 -0.124 0.879 None 0.759 0.473 0.652033478655 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.56E-05 None 0 None 0 0 0
N/Y 9728 Ig-83 31 rs794729400 0.3515 -0.124 0.879 None 0.759 0.473 0.652033478655 gnomAD-4.0.0 6.84414E-07 None None None None I None 0 0 None 0 2.51927E-05 None 0 0 0 0 0
K/N 9931 Ig-84 32 None 0.7474 None 0.801 None 0.502 0.182 0.136095386433 gnomAD-4.0.0 1.59616E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86561E-06 0 0
K/I 10018 Ig-85 30 None 0.563 None 0.171 None 0.366 0.304 0.457650129517 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
I/T 10107 Ig-86 30 None 0.6183 None 0.801 None 0.572 0.259 0.683524595578 gnomAD-4.0.0 1.59085E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85745E-06 0 0
I/T 13716 Ig-87 33 None 0.4529 None 0.201 N 0.643 0.306 0.59589940523 gnomAD-4.0.0 3.18385E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86566E-05 0
I/V 13716 Ig-87 33 rs531807386 0.0686 -0.124 0.001 N 0.257 0.06 0.396044805602 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 4.64E-05 0 0
I/V 13716 Ig-87 33 rs531807386 0.0686 -0.124 0.001 N 0.257 0.06 0.396044805602 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 1.93874E-04 None 0 0 0 2.07297E-04 0
I/V 13716 Ig-87 33 rs531807386 0.0686 -0.124 0.001 N 0.257 0.06 0.396044805602 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
I/V 13716 Ig-87 33 rs531807386 0.0686 -0.124 0.001 N 0.257 0.06 0.396044805602 gnomAD-4.0.0 4.95829E-06 None None None None N None 0 0 None 0 4.46728E-05 None 1.56216E-05 0 3.39101E-06 1.09803E-05 0
D/N 13809 Ig-88 30 rs761516226 0.1861 0.001 0.059 N 0.271 0.083 0.101711395817 gnomAD-2.1.1 8.06E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 8.9E-06 0
D/N 13809 Ig-88 30 rs761516226 0.1861 0.001 0.059 N 0.271 0.083 0.101711395817 gnomAD-4.0.0 3.18579E-06 None None None None I None 0 2.2877E-05 None 0 0 None 0 0 2.86059E-06 0 0
P/L 13994 Ig-90 30 rs1380914730 0.261 -0.094 0.278 N 0.429 0.21 0.20549828249 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
P/L 13994 Ig-90 30 rs1380914730 0.261 -0.094 0.278 N 0.429 0.21 0.20549828249 gnomAD-4.0.0 1.36881E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99669E-07 1.15974E-05 0
P/S 13994 Ig-90 30 rs201232835 0.2631 -0.485 0.483 N 0.344 0.152 None gnomAD-2.1.1 3.62E-05 None None None None N None 0 5.8E-05 None 4.97611E-04 0 None 0 None 0 1.78E-05 0
P/S 13994 Ig-90 30 rs201232835 0.2631 -0.485 0.483 N 0.344 0.152 None gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 5.76037E-04 0 None 0 0 0 0 0
P/S 13994 Ig-90 30 rs201232835 0.2631 -0.485 0.483 N 0.344 0.152 None gnomAD-4.0.0 1.17782E-05 None None None None N None 1.33568E-05 3.33611E-05 None 3.71797E-04 0 None 0 0 8.47813E-07 0 6.40779E-05
P/T 13994 Ig-90 30 rs201232835 0.2142 -0.491 0.651 N 0.321 0.086 0.156986980423 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
P/T 13994 Ig-90 30 rs201232835 0.2142 -0.491 0.651 N 0.321 0.086 0.156986980423 gnomAD-4.0.0 1.36883E-06 None None None None N None 0 0 None 0 5.04668E-05 None 0 0 0 0 0
N/K 14082 Ig-91 29 rs907132563 0.3377 None 0.044 N 0.154 0.144 0.0551355673512 gnomAD-3.1.2 1.97E-05 None None None None N None 0 1.31234E-04 0 0 0 None 0 0 1.47E-05 0 0
N/K 14082 Ig-91 29 rs907132563 0.3377 None 0.044 N 0.154 0.144 0.0551355673512 gnomAD-4.0.0 4.33938E-06 None None None None N None 0 3.33656E-05 None 0 0 None 0 0 4.23898E-06 0 0
N/S 14082 Ig-91 29 None 0.0846 None 0.91 N 0.498 0.227 0.154104182512 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
H/Q 14171 Ig-92 30 rs142842339 0.1055 None 0.784 N 0.31 0.2 0.0551355673512 gnomAD-4.0.0 6.84363E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15953E-05 0
H/R 14171 Ig-92 30 rs1288547551 0.0914 -0.001 0.784 N 0.282 0.237 0.253726318573 gnomAD-2.1.1 7.15E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.57E-05 0
H/R 14171 Ig-92 30 rs1288547551 0.0914 -0.001 0.784 N 0.282 0.237 0.253726318573 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
H/R 14171 Ig-92 30 rs1288547551 0.0914 -0.001 0.784 N 0.282 0.237 0.253726318573 gnomAD-4.0.0 4.95887E-06 None None None None N None 0 0 None 0 0 None 0 0 6.78235E-06 0 0
P/S 14259 Ig-93 29 rs1466149919 0.1189 -0.345 0.999 N 0.633 0.375 0.366659145958 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
P/S 14259 Ig-93 29 rs1466149919 0.1189 -0.345 0.999 N 0.633 0.375 0.366659145958 gnomAD-4.0.0 1.59234E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85969E-06 0 0
R/L 14526 Ig-96 30 rs373491468 0.1527 0.527 None N 0.289 0.263 0.128392430309 gnomAD-2.1.1 1.26E-05 None None None None N None 6.86E-05 0 None 0 0 None 3.42E-05 None 0 9.31E-06 0
R/L 14526 Ig-96 30 rs373491468 0.1527 0.527 None N 0.289 0.263 0.128392430309 gnomAD-4.0.0 1.37382E-06 None None None None N None 0 0 None 0 0 None 0 0 9.01717E-07 1.17327E-05 0
R/Q 14526 Ig-96 30 None 0.1047 0.137 0.003 N 0.261 0.16 None gnomAD-2.1.1 1.03826E-04 None None None None N None 8.59E-05 8.78E-05 None 0 0 None 3.42E-05 None 0 1.70879E-04 1.44175E-04
R/Q 14526 Ig-96 30 None 0.1047 0.137 0.003 N 0.261 0.16 None gnomAD-3.1.2 1.71127E-04 None None None None N None 1.69221E-04 0 0 0 0 None 0 0 2.79486E-04 0 0
R/Q 14526 Ig-96 30 None 0.1047 0.137 0.003 N 0.261 0.16 None gnomAD-4.0.0 2.81142E-04 None None None None N None 1.33761E-04 8.44652E-05 None 0 0 None 0 0 3.46651E-04 2.22089E-05 4.33805E-04
P/L 14615 Ig-97 30 rs1281092990 0.1648 0.005 0.92 D 0.624 0.615 0.692581660658 gnomAD-2.1.1 4.04E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
P/L 14615 Ig-97 30 rs1281092990 0.1648 0.005 0.92 D 0.624 0.615 0.692581660658 gnomAD-4.0.0 2.05345E-06 None None None None N None 2.989E-05 0 None 0 0 None 0 0 1.79925E-06 0 0
P/A 14793 Ig-99 29 rs1401276737 0.0804 None 0.046 N 0.178 0.18 0.264081493735 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
P/A 14793 Ig-99 29 rs1401276737 0.0804 None 0.046 N 0.178 0.18 0.264081493735 gnomAD-4.0.0 1.31522E-05 None None None None N None 4.82695E-05 0 None 0 0 None 0 0 0 0 0
P/L 14793 Ig-99 29 None 0.1267 None 0.811 N 0.442 0.31 0.589101784295 gnomAD-4.0.0 1.59342E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86192E-06 0 0
P/Q 14793 Ig-99 29 rs768644303 0.1776 -0.227 0.968 N 0.451 0.313 0.399017061211 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
P/Q 14793 Ig-99 29 rs768644303 0.1776 -0.227 0.968 N 0.451 0.313 0.399017061211 gnomAD-4.0.0 3.18684E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86656E-05 0
K/T 14882 Ig-100 30 rs988336748 0.1606 None 0.684 N 0.507 0.311 0.36256342048 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
K/T 14882 Ig-100 30 rs988336748 0.1606 None 0.684 N 0.507 0.311 0.36256342048 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/T 14882 Ig-100 30 rs988336748 0.1606 None 0.684 N 0.507 0.311 0.36256342048 gnomAD-4.0.0 2.48061E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39227E-06 0 0
K/N 14971 Ig-101 30 rs757693661 0.3955 None 0.999 N 0.679 0.32 0.3571064206 gnomAD-4.0.0 2.06767E-06 None None None None N None 0 0 None 0 0 None 0 0 2.71186E-06 0 0
K/Q 14971 Ig-101 30 None 0.1847 None 0.998 N 0.655 0.291 0.322786055943 gnomAD-4.0.0 1.61498E-06 None None None None N None 0 0 None 0 0 None 0 0 2.89548E-06 0 0
N/D 15420 Ig-106 30 rs2058069795 0.1339 None None N 0.087 0.111 0.202086224978 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.57E-05 0 0 0 None 0 0 0 0 0
N/D 15420 Ig-106 30 rs2058069795 0.1339 None None N 0.087 0.111 0.202086224978 gnomAD-4.0.0 2.82719E-06 None None None None N None 0 4.24737E-05 None 0 0 None 0 0 0 0 0
N/S 15420 Ig-106 30 None 0.0801 None 0.003 N 0.139 0.094 0.143124449307 gnomAD-4.0.0 2.15934E-06 None None None None N None 0 0 None 0 2.56397E-05 None 0 0 1.85211E-06 0 0
E/D 15598 Ig-108 31 rs371987003 0.1159 None 0.996 N 0.485 0.166 0.440810947182 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.95E-05 0 0
E/D 15598 Ig-108 31 rs371987003 0.1159 None 0.996 N 0.485 0.166 0.440810947182 gnomAD-4.0.0 9.92776E-06 None None None None N None 0 0 None 0 0 None 0 0 1.35733E-05 0 0
E/K 15598 Ig-108 31 None 0.0925 None 0.992 N 0.541 0.335 0.429435026966 gnomAD-4.0.0 1.59583E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43419E-05 0
T/A 15993 Ig-109 26 rs1483141685 0.0894 -0.439 0.012 D 0.372 0.121 0.193865811164 gnomAD-2.1.1 4.04E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/A 15993 Ig-109 26 rs1483141685 0.0894 -0.439 0.012 D 0.372 0.121 0.193865811164 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/A 15993 Ig-109 26 rs1483141685 0.0894 -0.439 0.012 D 0.372 0.121 0.193865811164 gnomAD-4.0.0 3.72059E-06 None None None None I None 0 3.33879E-05 None 0 0 None 0 0 1.69609E-06 2.19621E-05 0
T/N 15993 Ig-109 26 rs727503622 0.129 -0.226 0.029 N 0.511 0.147 0.28492961333 gnomAD-2.1.1 4.85E-05 None None None None I None 0 0 None 0 2.80143E-04 None 3.27E-05 None 0 4.48E-05 1.66389E-04
T/N 15993 Ig-109 26 rs727503622 0.129 -0.226 0.029 N 0.511 0.147 0.28492961333 gnomAD-3.1.2 3.95E-05 None None None None I None 0 0 0 0 3.8956E-04 None 0 0 4.42E-05 2.07383E-04 0
T/N 15993 Ig-109 26 rs727503622 0.129 -0.226 0.029 N 0.511 0.147 0.28492961333 gnomAD-4.0.0 5.95271E-05 None None None None I None 0 0 None 0 1.61009E-03 None 0 0 1.18729E-05 6.5895E-05 6.40841E-05
K/T 16289 Ig-110 28 None 0.1433 None None N 0.263 0.087 0.101711395817 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 16985 Ig-111 31 None 0.0684 None 0.826 N 0.436 0.241 0.306377322295 gnomAD-4.0.0 2.73844E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59934E-06 0 0
T/I 16985 Ig-111 31 rs116765281 0.1203 0.028 0.996 D 0.567 0.372 None gnomAD-2.1.1 5.73E-05 None None None None I None 0 0 None 0 0 None 0 None 0 1.25315E-04 0
T/I 16985 Ig-111 31 rs116765281 0.1203 0.028 0.996 D 0.567 0.372 None gnomAD-3.1.2 4.61E-05 None None None None I None 7.25E-05 0 0 0 0 None 0 0 5.89E-05 0 0
T/I 16985 Ig-111 31 rs116765281 0.1203 0.028 0.996 D 0.567 0.372 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
T/I 16985 Ig-111 31 rs116765281 0.1203 0.028 0.996 D 0.567 0.372 None gnomAD-4.0.0 1.30214E-04 None None None None I None 4.00267E-05 0 None 0 0 None 0 0 1.67904E-04 0 1.44194E-04
T/P 16985 Ig-111 31 rs1301584675 0.3401 None 0.996 D 0.563 0.522 0.453119318887 gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
T/P 16985 Ig-111 31 rs1301584675 0.3401 None 0.996 D 0.563 0.522 0.453119318887 gnomAD-4.0.0 1.31619E-05 None None None None I None 4.82882E-05 0 None 0 0 None 0 0 0 0 0
T/S 16985 Ig-111 31 rs1301584675 0.0953 None 0.826 N 0.447 0.186 0.212008924253 gnomAD-4.0.0 6.84609E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.65832E-05
T/I 17278 Ig-112 28 None 0.1372 None 0.966 D 0.613 0.289 0.475272412942 gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.93751E-06 0 0
T/S 17278 Ig-112 28 None 0.098 None 0.051 D 0.171 0.106 0.243972157842 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 17703 Ig-113 27 None 0.0783 None 0.011 D 0.149 0.198 0.229924730088 gnomAD-4.0.0 1.59233E-06 None None None None I None 0 0 None 0 0 None 1.88338E-05 0 0 0 0
T/S 17703 Ig-113 27 None 0.1067 None 0.123 N 0.148 0.091 0.204665344411 gnomAD-4.0.0 1.59233E-06 None None None None I None 0 0 None 0 2.77423E-05 None 0 0 0 0 0
K/N 17997 Ig-114 30 None 0.3161 None 1.0 N 0.733 0.293 0.329282125956 gnomAD-4.0.0 4.78292E-06 None None None None I None 0 0 None 0 0 None 0 0 8.5888E-06 0 0
K/E 18409 Ig-115 28 None 0.1964 None 0.928 N 0.538 0.29 0.356484672536 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 3.66327E-05
T/A 19123 Ig-117 29 rs587782985 0.064 -0.264 0.002 N 0.143 0.123 0.206339911435 gnomAD-2.1.1 3.63E-05 None None None None I None 0 0 None 0 0 None 1.96078E-04 None 0 2.68E-05 0
T/A 19123 Ig-117 29 rs587782985 0.064 -0.264 0.002 N 0.143 0.123 0.206339911435 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 2.07039E-04 0
T/A 19123 Ig-117 29 rs587782985 0.064 -0.264 0.002 N 0.143 0.123 0.206339911435 gnomAD-4.0.0 1.92162E-05 None None None None I None 0 1.66845E-05 None 0 0 None 0 1.64474E-04 1.18687E-05 1.53725E-04 1.60164E-05
T/I 19123 Ig-117 29 None 0.0857 None 0.473 N 0.325 0.13 0.307016933798 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
K/T 19417 Ig-118 27 rs2050890931 0.0763 None 0.134 N 0.23 0.26 0.31291088546 gnomAD-4.0.0 1.5921E-06 None None None None I None 5.65739E-05 0 None 0 0 None 0 0 0 0 0
T/A 20109 Ig-120 30 None 0.069 None 0.008 N 0.223 0.105 0.198526703765 gnomAD-4.0.0 1.59397E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43583E-05 0
T/I 20109 Ig-120 30 rs2050161903 0.0999 None 0.565 N 0.559 0.392 0.397691132334 gnomAD-4.0.0 2.05409E-06 None None None None N None 0 0 None 0 2.5208E-05 None 0 0 1.79975E-06 0 0
T/N 20109 Ig-120 30 rs2050161903 0.1129 None 0.901 N 0.55 0.384 0.389596023526 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/N 20109 Ig-120 30 rs2050161903 0.1129 None 0.901 N 0.55 0.384 0.389596023526 gnomAD-4.0.0 1.86043E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54399E-06 0 0
D/G 20507 Ig-121 29 None 0.1847 None 0.896 N 0.521 0.346 0.353336612579 gnomAD-4.0.0 1.60609E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.04544E-05
D/H 20507 Ig-121 29 rs777239380 0.2107 -0.209 0.984 N 0.609 0.377 0.394837016283 gnomAD-2.1.1 4.13E-06 None None None None I None 0 0 None 0 0 None 3.47E-05 None 0 0 0
D/H 20507 Ig-121 29 rs777239380 0.2107 -0.209 0.984 N 0.609 0.377 0.394837016283 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.06782E-04 0
D/H 20507 Ig-121 29 rs777239380 0.2107 -0.209 0.984 N 0.609 0.377 0.394837016283 gnomAD-4.0.0 6.57722E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.06782E-04 0
D/Y 20507 Ig-121 29 None 0.2092 None 0.995 N 0.695 0.447 0.577897453458 gnomAD-4.0.0 1.60751E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.04711E-05
E/G 20800 Ig-122 32 rs1404277332 0.2712 -0.449 0.822 N 0.608 0.337 0.465294738428 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.58E-05 None 0 None 0 0 0
E/G 20800 Ig-122 32 rs1404277332 0.2712 -0.449 0.822 N 0.608 0.337 0.465294738428 gnomAD-4.0.0 1.59335E-06 None None None None I None 0 0 None 0 2.7767E-05 None 0 0 0 0 0
K/E 21205 Ig-123 29 rs794727409 0.1824 0.384 0.41 N 0.576 0.283 0.303781844768 gnomAD-2.1.1 7.16E-06 None None None None I None 0 2.84E-05 None 0 0 None 0 None 0 7.84E-06 0
K/E 21205 Ig-123 29 rs794727409 0.1824 0.384 0.41 N 0.576 0.283 0.303781844768 gnomAD-3.1.2 1.97E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
K/E 21205 Ig-123 29 rs794727409 0.1824 0.384 0.41 N 0.576 0.283 0.303781844768 gnomAD-4.0.0 6.20028E-06 None None None None I None 1.33622E-05 1.66856E-05 None 0 0 None 0 0 6.78306E-06 0 0
K/I 21205 Ig-123 29 rs886042512 0.3573 0.863 0.908 N 0.737 0.392 0.523082183605 gnomAD-2.1.1 1.21E-05 None None None None I None 0 8.72E-05 None 0 0 None 0 None 0 0 0
K/I 21205 Ig-123 29 rs886042512 0.3573 0.863 0.908 N 0.737 0.392 0.523082183605 gnomAD-4.0.0 4.7792E-06 None None None None I None 0 6.8653E-05 None 0 0 None 0 0 0 0 0
K/N 21205 Ig-123 29 rs771189924 0.4137 0.093 0.83 N 0.693 0.215 0.310458034454 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/N 21205 Ig-123 29 rs771189924 0.4137 0.093 0.83 N 0.693 0.215 0.310458034454 gnomAD-4.0.0 1.59312E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43361E-05 0
T/I 21497 Ig-124 29 rs1236376736 0.0559 0.192 None N 0.118 0.143 0.0954503805726 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
T/I 21497 Ig-124 29 rs1236376736 0.0559 0.192 None N 0.118 0.143 0.0954503805726 gnomAD-4.0.0 1.36883E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79943E-06 0 0
T/A 21894 Ig-125 29 None 0.0665 None 0.002 N 0.144 0.142 0.21279746466 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
T/I 21894 Ig-125 29 rs761924206 0.1211 0.12 0.81 N 0.631 0.26 0.376039117802 gnomAD-2.1.1 1.22E-05 None None None None N None 0 0 None 0 1.13701E-04 None 3.29E-05 None 0 0 0
T/I 21894 Ig-125 29 rs761924206 0.1211 0.12 0.81 N 0.631 0.26 0.376039117802 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 1.94553E-04 None 0 0 0 2.07211E-04 0
T/I 21894 Ig-125 29 rs761924206 0.1211 0.12 0.81 N 0.631 0.26 0.376039117802 gnomAD-4.0.0 6.8238E-06 None None None None N None 0 0 None 3.38249E-05 4.49156E-05 None 1.56416E-05 0 2.54468E-06 4.40131E-05 0
T/R 21894 Ig-125 29 None 0.1136 None 0.016 N 0.293 0.341 0.396794106654 gnomAD-4.0.0 6.84972E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00118E-07 0 0
T/S 21894 Ig-125 29 None 0.0979 None 0.016 N 0.161 0.115 0.181679512989 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/T 22292 Ig-126 28 None 0.1617 None 1.0 N 0.699 0.506 0.419335720491 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/T 22581 Ig-127 22 rs1318211232 0.0544 None 0.001 N 0.163 0.073 0.104622674875 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
S/T 22581 Ig-127 22 rs1318211232 0.0544 None 0.001 N 0.163 0.073 0.104622674875 gnomAD-4.0.0 5.12877E-06 None None None None I None 0 0 None 0 0 None 0 0 9.579E-06 0 0
T/I 23664 Ig-130 28 rs774999533 0.095 0.096 0.051 N 0.17 0.202 0.29132392195 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 0 0
T/I 23664 Ig-130 28 rs774999533 0.095 0.096 0.051 N 0.17 0.202 0.29132392195 gnomAD-4.0.0 2.73866E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79962E-06 2.32105E-05 0
T/A 24060 Ig-131 32 rs1709156357 0.0695 None 0.835 N 0.399 0.182 0.244539031024 gnomAD-4.0.0 1.08029E-05 None None None None I None 0 0 None 0 0 None 0 0 1.18125E-05 0 0
T/I 24060 Ig-131 32 None 0.1117 None 0.994 D 0.651 0.396 0.547935346631 gnomAD-4.0.0 1.59224E-06 None None None None I None 0 0 None 0 0 None 0 2.41429E-04 0 0 0
E/G 24459 Ig-132 29 None 0.258 None 0.892 D 0.556 0.5 0.671833516112 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 24459 Ig-132 29 rs1446425983 0.1399 None 0.892 N 0.541 0.325 0.458101713262 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 24459 Ig-132 29 rs1446425983 0.1399 None 0.892 N 0.541 0.325 0.458101713262 gnomAD-4.0.0 4.33869E-06 None None None None I None 1.33529E-05 0 None 0 0 None 0 0 4.2387E-06 0 1.60128E-05
T/A 25142 Ig-134 32 rs1707881545 0.0656 None 0.002 N 0.159 0.098 0.176091768786 gnomAD-4.0.0 1.59167E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85933E-06 0 0
E/G 25541 Ig-135 28 None 0.2182 None 0.988 D 0.617 0.521 0.501308276186 gnomAD-4.0.0 1.59406E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86377E-06 0 0
T/N 25828 Ig-136 31 rs763550644 0.0921 -0.467 0.331 D 0.48 0.197 None gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 1.67448E-04 None 0 None 0 0 0
T/N 25828 Ig-136 31 rs763550644 0.0921 -0.467 0.331 D 0.48 0.197 None gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 3.87297E-04 None 0 0 0 0 0
T/N 25828 Ig-136 31 rs763550644 0.0921 -0.467 0.331 D 0.48 0.197 None gnomAD-4.0.0 4.15314E-05 None None None None I None 0 0 None 0 1.47256E-03 None 0 0 0 0 1.60159E-05
T/A 26224 Ig-137 32 rs1480422530 0.0713 -0.341 0.028 N 0.263 0.195 0.165133752707 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/A 26224 Ig-137 32 rs1480422530 0.0713 -0.341 0.028 N 0.263 0.195 0.165133752707 gnomAD-4.0.0 6.84535E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99732E-07 0 0
T/I 26224 Ig-137 32 rs756093359 0.138 0.138 0.939 D 0.567 0.459 0.459100921832 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
T/I 26224 Ig-137 32 rs756093359 0.138 0.138 0.939 D 0.567 0.459 0.459100921832 gnomAD-4.0.0 1.59296E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43517E-05 0
E/D 26623 Ig-138 30 rs751704572 0.0796 None 0.001 N 0.177 0.08 0.165133752707 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/D 26623 Ig-138 30 rs751704572 0.0796 None 0.001 N 0.177 0.08 0.165133752707 gnomAD-4.0.0 6.5735E-06 None None None None I None 2.41324E-05 0 None 0 0 None 0 0 0 0 0
E/K 26623 Ig-138 30 rs1705804390 0.1344 None 0.003 N 0.293 0.179 0.340273420219 gnomAD-4.0.0 2.737E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59809E-06 0 0
N/D 26910 Ig-139 31 rs1456879074 0.1102 0.126 0.003 N 0.213 0.148 0.136095386433 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
N/D 26910 Ig-139 31 rs1456879074 0.1102 0.126 0.003 N 0.213 0.148 0.136095386433 gnomAD-4.0.0 1.59173E-06 None None None None I None 0 2.28676E-05 None 0 0 None 0 0 0 0 0
E/K 27706 Ig-141 31 rs72648217 0.1296 0.196 0.287 N 0.329 0.288 0.296679040009 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 1.78E-05 0
E/K 27706 Ig-141 31 rs72648217 0.1296 0.196 0.287 N 0.329 0.288 0.296679040009 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 4.1425E-04 0
E/K 27706 Ig-141 31 rs72648217 0.1296 0.196 0.287 N 0.329 0.288 0.296679040009 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
E/K 27706 Ig-141 31 rs72648217 0.1296 0.196 0.287 N 0.329 0.288 0.296679040009 gnomAD-4.0.0 2.29294E-05 None None None None N None 0 0 None 0 0 None 0 0 2.11921E-05 1.31755E-04 0
T/A 27993 Ig-142 31 rs752491962 0.0647 -0.51 None N 0.106 0.081 0.241664281697 gnomAD-2.1.1 7.18E-06 None None None None I None 4.15E-05 0 None 0 0 None 3.28E-05 None 0 0 0
T/A 27993 Ig-142 31 rs752491962 0.0647 -0.51 None N 0.106 0.081 0.241664281697 gnomAD-4.0.0 4.77852E-06 None None None None I None 5.66059E-05 0 None 0 0 None 0 0 2.86008E-06 1.43382E-05 0
T/I 27993 Ig-142 31 rs377614000 0.0967 None 0.213 N 0.377 0.278 0.50143340055 gnomAD-4.0.0 6.84518E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.65744E-05
T/N 27993 Ig-142 31 rs377614000 0.1075 -0.057 0.213 N 0.24 0.243 None gnomAD-2.1.1 2.16E-05 None None None None I None 0 0 None 0 0 None 0 None 0 4.73E-05 0
T/N 27993 Ig-142 31 rs377614000 0.1075 -0.057 0.213 N 0.24 0.243 None gnomAD-3.1.2 5.26E-05 None None None None I None 0 0 0 0 0 None 0 0 1.17606E-04 0 0
T/N 27993 Ig-142 31 rs377614000 0.1075 -0.057 0.213 N 0.24 0.243 None gnomAD-4.0.0 4.40168E-05 None None None None I None 0 0 None 0 0 None 0 0 5.68012E-05 0 6.40759E-05
V/E 28388 Ig-143 31 rs1425261551 0.2042 -0.244 0.497 N 0.733 0.399 0.592282861509 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
V/E 28388 Ig-143 31 rs1425261551 0.2042 -0.244 0.497 N 0.733 0.399 0.592282861509 gnomAD-4.0.0 3.1825E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71618E-06 0 0
N/K 28785 Ig-144 31 rs745857020 0.2308 0.157 0.062 N 0.311 0.165 0.0884992946249 gnomAD-2.1.1 4.14E-06 None None None None I None 0 0 None 0 0 None 3.45E-05 None 0 0 0
N/K 28785 Ig-144 31 rs745857020 0.2308 0.157 0.062 N 0.311 0.165 0.0884992946249 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07383E-04 0
N/K 28785 Ig-144 31 rs745857020 0.2308 0.157 0.062 N 0.311 0.165 0.0884992946249 gnomAD-4.0.0 1.2461E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.23065E-05 0
N/S 28785 Ig-144 31 rs775051962 0.0596 -0.343 None N 0.143 0.209 0.0297737177859 gnomAD-2.1.1 4.14E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.08E-06 0
N/S 28785 Ig-144 31 rs775051962 0.0596 -0.343 None N 0.143 0.209 0.0297737177859 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
N/S 28785 Ig-144 31 rs775051962 0.0596 -0.343 None N 0.143 0.209 0.0297737177859 gnomAD-4.0.0 1.86921E-06 None None None None I None 1.33786E-05 0 None 0 0 None 0 1.65673E-04 8.5047E-07 0 0
K/Q 29075 Ig-145 31 rs1324821269 0.121 0.391 1.0 N 0.744 0.412 0.38242337071 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/Q 29075 Ig-145 31 rs1324821269 0.121 0.391 1.0 N 0.744 0.412 0.38242337071 gnomAD-4.0.0 1.59117E-06 None None None None I None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
T/A 29870 Ig-147 29 rs372796632 0.0693 -0.565 0.454 N 0.39 0.208 None gnomAD-2.1.1 4.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/A 29870 Ig-147 29 rs372796632 0.0693 -0.565 0.454 N 0.39 0.208 None gnomAD-4.0.0 6.86391E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99475E-07 0 0
T/P 29870 Ig-147 29 None 0.4287 None 0.966 D 0.524 0.585 0.557713733399 gnomAD-4.0.0 6.86391E-07 None None None None N None 0 0 None 0 0 None 0 1.7343E-04 0 0 0
R/P 30557 Ig-149 26 None 0.6836 None 0.902 N 0.436 0.446 0.504848970537 gnomAD-4.0.0 6.84218E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99502E-07 0 0
R/Q 30557 Ig-149 26 rs745646703 0.0775 0.32 0.019 N 0.156 0.139 0.149567049428 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 4.64E-05 1.78E-05 0
R/Q 30557 Ig-149 26 rs745646703 0.0775 0.32 0.019 N 0.156 0.139 0.149567049428 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/Q 30557 Ig-149 26 rs745646703 0.0775 0.32 0.019 N 0.156 0.139 0.149567049428 gnomAD-4.0.0 1.79719E-05 None None None None I None 0 0 None 0 2.22826E-05 None 3.12471E-05 0 2.03434E-05 1.09794E-05 1.60118E-05
K/R 31246 Ig-151 29 rs775611779 0.0756 -0.052 0.002 N 0.379 0.101 None gnomAD-2.1.1 1.07E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.34E-05 0
K/R 31246 Ig-151 29 rs775611779 0.0756 -0.052 0.002 N 0.379 0.101 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 4.78927E-04
K/R 31246 Ig-151 29 rs775611779 0.0756 -0.052 0.002 N 0.379 0.101 None gnomAD-4.0.0 1.30135E-05 None None None None I None 0 0 None 0 0 None 0 0 1.69516E-05 0 1.60118E-05
K/T 31646 Ig-152 26 None 0.1968 None 0.543 N 0.33 0.286 0.280181792013 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/T 32337 Ig-154 31 None 0.0643 None None N 0.133 0.064 0.165133752707 gnomAD-4.0.0 1.59121E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02389E-05
I/V 32735 Ig-155 28 rs761246331 0.0619 -0.802 None N 0.185 0.065 None gnomAD-2.1.1 3.92E-05 None None None None I None 2.47954E-04 1.41443E-04 None 0 0 None 0 None 0 0 0
I/V 32735 Ig-155 28 rs761246331 0.0619 -0.802 None N 0.185 0.065 None gnomAD-3.1.2 8.54E-05 None None None None I None 3.13797E-04 0 0 0 0 None 0 0 0 0 0
I/V 32735 Ig-155 28 rs761246331 0.0619 -0.802 None N 0.185 0.065 None gnomAD-4.0.0 1.92108E-05 None None None None I None 2.93725E-04 1.0002E-04 None 0 0 None 0 0 8.4763E-07 0 3.20195E-05
A/D 33227 Ig-157 25 rs1430566252 0.259 -1.725 0.175 N 0.449 0.297 0.456089687795 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 2.87687E-04 0 0
A/D 33227 Ig-157 25 rs1430566252 0.259 -1.725 0.175 N 0.449 0.297 0.456089687795 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 9.42E-05 0 0 0 0
A/D 33227 Ig-157 25 rs1430566252 0.259 -1.725 0.175 N 0.449 0.297 0.456089687795 gnomAD-4.0.0 6.57462E-06 None None None None I None 0 0 None 0 0 None 9.42329E-05 0 0 0 0
A/V 33227 Ig-157 25 rs1430566252 0.1202 -0.434 0.229 N 0.304 0.139 0.362960570912 gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.77E-05 0
A/V 33227 Ig-157 25 rs1430566252 0.1202 -0.434 0.229 N 0.304 0.139 0.362960570912 gnomAD-4.0.0 3.42123E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59796E-06 0 1.65689E-05
I/M 33526 Ig-158 31 None 0.1008 None 0.088 N 0.497 0.078 0.149567049428 gnomAD-4.0.0 1.36866E-06 None None None None I None 5.97693E-05 0 None 0 0 None 0 0 0 0 0
I/T 33526 Ig-158 31 None 0.122 None None N 0.226 0.178 0.475971816791 gnomAD-4.0.0 1.59176E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85904E-06 0 0
I/V 33526 Ig-158 31 None 0.0561 None None N 0.129 0.108 0.141422826196 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 6.17284E-04 0 0 0
V/M 33626 Ig-159 31 rs1222398324 0.4334 None 0.999 N 0.588 0.276 0.525561869914 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
V/M 33626 Ig-159 31 rs1222398324 0.4334 None 0.999 N 0.588 0.276 0.525561869914 gnomAD-4.0.0 1.48744E-05 None None None None I None 0 0 None 0 0 None 0 0 2.03427E-05 0 0
T/I 34393 Ig-162 31 rs372299779 0.1564 0.069 0.988 N 0.521 0.37 None gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
T/I 34393 Ig-162 31 rs372299779 0.1564 0.069 0.988 N 0.521 0.37 None gnomAD-4.0.0 5.4735E-06 None None None None I None 0 0 None 0 0 None 0 0 7.1954E-06 0 0
T/P 34393 Ig-162 31 rs947426325 0.6221 -0.226 0.988 N 0.513 0.507 0.452450644169 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/P 34393 Ig-162 31 rs947426325 0.6221 -0.226 0.988 N 0.513 0.507 0.452450644169 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 0 4.78011E-04
T/P 34393 Ig-162 31 rs947426325 0.6221 -0.226 0.988 N 0.513 0.507 0.452450644169 gnomAD-4.0.0 1.05346E-05 None None None None I None 0 3.33367E-05 None 0 0 None 0 0 1.18661E-05 0 1.60097E-05
E/A 34972 Ig-163 31 None 0.2403 None 0.505 N 0.591 0.367 0.437958778045 gnomAD-4.0.0 1.59089E-06 None None None None N None 0 0 None 0 2.77239E-05 None 0 0 0 0 0
E/K 34972 Ig-163 31 rs727504918 0.2432 0.69 0.742 N 0.544 0.324 None gnomAD-2.1.1 2.41E-05 None None None None N None 0 0 None 0 0 None 0 None 0 5.32E-05 0
E/K 34972 Ig-163 31 rs727504918 0.2432 0.69 0.742 N 0.544 0.324 None gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
E/K 34972 Ig-163 31 rs727504918 0.2432 0.69 0.742 N 0.544 0.324 None gnomAD-4.0.0 3.96564E-05 None None None None N None 1.33472E-05 0 None 0 0 None 0 0 5.25478E-05 0 1.60087E-05
T/N 35159 Ig-164 31 rs1468368780 0.1162 -0.586 0.005 D 0.34 0.126 0.19670166235 gnomAD-2.1.1 4.01E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.86E-06 0
T/N 35159 Ig-164 31 rs1468368780 0.1162 -0.586 0.005 D 0.34 0.126 0.19670166235 gnomAD-4.0.0 1.59087E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8575E-06 0 0
E/Q 35316 Ig-165 31 None 0.2951 None 1.0 N 0.625 0.264 0.460264052551 gnomAD-4.0.0 1.59086E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85745E-06 0 0
T/I 35450 Ig-166 31 rs371022420 0.1308 None 0.863 N 0.596 0.139 0.347879110917 gnomAD-4.0.0 1.37635E-06 None None None None N None 0 4.56892E-05 None 0 0 None 0 0 0 0 0
T/S 35450 Ig-166 31 rs371022420 0.112 -0.73 0.029 N 0.179 0.117 0.104622674875 gnomAD-2.1.1 6.14E-05 None None None None N None 3.73196E-04 2.02324E-04 None 0 0 None 0 None 0 0 1.42613E-04
T/S 35450 Ig-166 31 rs371022420 0.112 -0.73 0.029 N 0.179 0.117 0.104622674875 gnomAD-3.1.2 1.6423E-04 None None None None N None 5.78787E-04 6.54E-05 0 0 0 None 0 0 0 0 0
T/S 35450 Ig-166 31 rs371022420 0.112 -0.73 0.029 N 0.179 0.117 0.104622674875 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
T/S 35450 Ig-166 31 rs371022420 0.112 -0.73 0.029 N 0.179 0.117 0.104622674875 gnomAD-4.0.0 3.48809E-05 None None None None N None 5.7616E-04 2.03114E-04 None 0 0 None 0 0 0 0 1.61041E-05
D/E 35635 Ig-167 29 rs1255745337 0.2582 0.12 0.001 N 0.128 0.061 0.110078149338 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/E 35635 Ig-167 29 rs1255745337 0.2582 0.12 0.001 N 0.128 0.061 0.110078149338 gnomAD-4.0.0 1.3683E-06 None None None None N None 0 2.23624E-05 None 0 0 None 0 0 8.99399E-07 0 0
D/H 35635 Ig-167 29 None 0.4659 None 0.773 N 0.441 0.32 0.254244900254 gnomAD-4.0.0 6.8415E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99399E-07 0 0
D/N 35635 Ig-167 29 None 0.1253 None 0.324 N 0.348 0.213 0.192905019026 gnomAD-4.0.0 1.3683E-06 None None None None N None 2.98686E-05 0 None 0 0 None 0 0 8.99399E-07 0 0
E/D 35732 Ig-168 31 None 0.2511 None 0.002 N 0.126 0.049 0.232513804876 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 35732 Ig-168 31 None 0.2708 None 0.016 N 0.205 0.217 0.344945010812 gnomAD-4.0.0 6.85714E-07 None None None None I None 0 0 None 0 0 None 0 0 9.0111E-07 0 0
E/A 35927 Ig-169 31 rs1558954742 0.1494 -0.175 0.081 N 0.408 0.198 0.325533332567 gnomAD-2.1.1 4.02E-06 None None None -1.683(OBSL1) -0.185(OBSCN) N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
E/A 35927 Ig-169 31 rs1558954742 0.1494 -0.175 0.081 N 0.408 0.198 0.325533332567 gnomAD-4.0.0 2.73663E-06 None None None -1.683(OBSL1) -0.185(OBSCN) N None 0 0 None 0 0 None 0 0 3.59763E-06 0 0
E/K 35927 Ig-169 31 rs751773148 0.1186 0.703 0.042 N 0.388 0.244 0.243972157842 gnomAD-2.1.1 8.03E-06 None None None -1.925(OBSL1) 0.135(OBSCN) N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
E/K 35927 Ig-169 31 rs751773148 0.1186 0.703 0.042 N 0.388 0.244 0.243972157842 gnomAD-4.0.0 3.42087E-06 None None None -1.925(OBSL1) 0.135(OBSCN) N None 0 0 None 0 0 None 0 0 0 5.79831E-05 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.