Structural position:

  • Domain Type: Ig
  • Aligned Position: 46
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand C

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
V/G 37 Ig-1 32 None 0.8553 None 1.0 D 0.875 0.922 0.942146901664 gnomAD-4.0.0 1.08131E-05 None None None -0.586(TCAP) N None 0 0 None 0 0 None 0 0 1.051E-05 0 3.66623E-05
V/E 135 Ig-2 32 rs1332868582 0.9923 None 1.0 D 0.851 0.827 0.899657565886 gnomAD-3.1.2 6.57E-06 None None None -0.599(TCAP) N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/E 135 Ig-2 32 rs1332868582 0.9923 None 1.0 D 0.851 0.827 0.899657565886 gnomAD-4.0.0 1.85875E-06 None None None -0.599(TCAP) N None 0 0 None 0 0 None 0 0 1.69488E-06 0 1.60046E-05
V/M 135 Ig-2 32 None 0.7759 None 1.0 D 0.701 0.63 0.764807200997 gnomAD-4.0.0 1.59059E-06 None None None -0.73(TCAP) N None 0 0 None 0 0 None 0 0 2.85662E-06 0 0
V/L 974 Ig-3 32 rs749511236 0.7846 None 0.9 N 0.576 0.392 0.650309897564 gnomAD-4.0.0 1.36816E-06 None None None None N None 0 0 None 0 5.04032E-05 None 0 0 0 0 0
V/M 974 Ig-3 32 rs749511236 0.7319 -0.528 0.997 D 0.712 0.433 0.733702516443 gnomAD-2.1.1 7.97E-06 None None None None N None 0 0 None 0 0 None 6.53E-05 None 0 0 0
V/M 974 Ig-3 32 rs749511236 0.7319 -0.528 0.997 D 0.712 0.433 0.733702516443 gnomAD-4.0.0 2.05224E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.47794E-05 0
V/A 1113 Ig-4 32 rs763409137 0.8061 -2.252 0.822 D 0.646 0.681 0.732157991247 gnomAD-2.1.1 7.97E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.76E-05 0
V/A 1113 Ig-4 32 rs763409137 0.8061 -2.252 0.822 D 0.646 0.681 0.732157991247 gnomAD-4.0.0 1.02611E-05 None None None None N None 0 0 None 0 0 None 0 0 1.34895E-05 0 0
I/L 1322 Ig-5 32 None 0.3874 None 0.58 N 0.442 0.413 0.541285430251 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 1488 Ig-6 32 rs146732280 0.2879 -0.811 0.999 N 0.572 0.477 None gnomAD-2.1.1 1.77E-05 None None None None I None 8.01E-05 0 None 0 0 None 0 None 0 2.33E-05 0
T/A 1488 Ig-6 32 rs146732280 0.2879 -0.811 0.999 N 0.572 0.477 None gnomAD-3.1.2 5.91E-05 None None None None I None 4.82E-05 0 0 0 0 None 0 0 1.02887E-04 0 0
T/A 1488 Ig-6 32 rs146732280 0.2879 -0.811 0.999 N 0.572 0.477 None gnomAD-4.0.0 9.91332E-05 None None None None I None 4.00342E-05 0 None 0 0 None 0 0 1.29664E-04 0 6.40164E-05
T/K 1488 Ig-6 32 None 0.9268 -0.747 1.0 N 0.799 0.687 0.587508425673 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/K 1488 Ig-6 32 None 0.9268 -0.747 1.0 N 0.799 0.687 0.587508425673 gnomAD-4.0.0 6.84118E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
T/M 1488 Ig-6 32 rs111282958 0.2201 0.095 1.0 N 0.794 0.548 None gnomAD-2.1.1 1.77E-05 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 2.33E-05 1.38696E-04
T/M 1488 Ig-6 32 rs111282958 0.2201 0.095 1.0 N 0.794 0.548 None gnomAD-3.1.2 3.29E-05 None None None None I None 4.83E-05 6.55E-05 0 0 0 None 0 0 2.94E-05 0 0
T/M 1488 Ig-6 32 rs111282958 0.2201 0.095 1.0 N 0.794 0.548 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
T/M 1488 Ig-6 32 rs111282958 0.2201 0.095 1.0 N 0.794 0.548 None gnomAD-4.0.0 7.00113E-05 None None None None I None 6.66507E-05 1.66644E-05 None 0 2.22826E-05 None 0 0 8.89858E-05 1.09798E-05 0
V/M 1736 Ig-8 34 rs2092259333 0.8269 None 1.0 D 0.76 0.759 0.758467727117 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/M 1736 Ig-8 34 rs2092259333 0.8269 None 1.0 D 0.76 0.759 0.758467727117 gnomAD-4.0.0 6.56875E-06 None None None None I None 2.41208E-05 0 None 0 0 None 0 0 0 0 0
V/L 1872 Ig-9 32 None 0.6532 None 0.039 D 0.309 0.286 0.332902724076 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
C/R 2109 Ig-10 32 rs773335568 0.9962 -0.924 1.0 N 0.867 0.717 0.82484877143 gnomAD-2.1.1 3.99E-06 None None disulfide None N None 0 0 None 0 5.46E-05 None 0 None 0 0 0
C/R 2109 Ig-10 32 rs773335568 0.9962 -0.924 1.0 N 0.867 0.717 0.82484877143 gnomAD-4.0.0 1.59081E-06 None None disulfide None N None 0 0 None 0 2.77608E-05 None 0 0 0 0 0
C/Y 2109 Ig-10 32 rs769946776 0.9807 -1.271 1.0 N 0.864 0.556 0.703262793419 gnomAD-2.1.1 5.58E-05 None None disulfide None N None 0 4.05562E-04 None 0 0 None 0 None 0 0 0
C/Y 2109 Ig-10 32 rs769946776 0.9807 -1.271 1.0 N 0.864 0.556 0.703262793419 gnomAD-4.0.0 1.16301E-05 None None disulfide None N None 0 3.80313E-04 None 0 0 None 0 0 0 0 0
V/M 2205 Ig-11 32 rs2154345518 0.6315 None 1.0 D 0.749 0.722 0.760968267486 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.9253E-04 None 0 0 0 0 0
V/M 2205 Ig-11 32 rs2154345518 0.6315 None 1.0 D 0.749 0.722 0.760968267486 gnomAD-4.0.0 6.56556E-06 None None None None N None 0 0 None 0 1.92976E-04 None 0 0 0 0 0
G/A 2297 Ig-12 31 None 0.2533 None 1.0 D 0.659 0.567 0.37479162749 gnomAD-4.0.0 1.59071E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85696E-06 0 0
G/D 2386 Ig-13 31 rs142926566 0.9604 -1.713 1.0 D 0.767 0.767 None gnomAD-2.1.1 3.54E-05 None None None None N None 2.80426E-04 0 None 0 0 None 0 None 0 7.76E-06 2.77546E-04
G/D 2386 Ig-13 31 rs142926566 0.9604 -1.713 1.0 D 0.767 0.767 None gnomAD-3.1.2 7.89E-05 None None None None N None 2.17161E-04 0 0 0 0 None 0 9.49367E-03 0 0 0
G/D 2386 Ig-13 31 rs142926566 0.9604 -1.713 1.0 D 0.767 0.767 None gnomAD-4.0.0 2.16843E-05 None None None None N None 3.59818E-04 0 None 0 0 None 0 4.94886E-04 8.47475E-07 0 6.39959E-05
G/S 2386 Ig-13 31 rs777101912 0.3869 -1.096 1.0 D 0.719 0.48 0.41921206133 gnomAD-2.1.1 8.5E-05 None None None None N None 0 0 None 0 1.20422E-03 None 0 None 0 0 0
G/S 2386 Ig-13 31 rs777101912 0.3869 -1.096 1.0 D 0.719 0.48 0.41921206133 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92678E-04 None 0 0 0 0 0
G/S 2386 Ig-13 31 rs777101912 0.3869 -1.096 1.0 D 0.719 0.48 0.41921206133 gnomAD-4.0.0 1.23918E-05 None None None None N None 0 0 None 0 4.2337E-04 None 0 0 0 0 1.60036E-05
V/I 2476 Ig-14 32 rs763541715 0.0863 -0.301 0.625 D 0.625 0.265 0.661693444866 gnomAD-2.1.1 7.97E-06 None None None None N None 0 0 None 0 1.09099E-04 None 0 None 0 0 0
V/I 2476 Ig-14 32 rs763541715 0.0863 -0.301 0.625 D 0.625 0.265 0.661693444866 gnomAD-4.0.0 3.18143E-06 None None None None N None 0 0 None 0 5.55031E-05 None 0 0 0 0 0
V/D 2563 Ig-15 31 rs775758080 0.8908 -2.187 0.959 D 0.766 0.908 0.879622353233 gnomAD-2.1.1 7.98E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
V/D 2563 Ig-15 31 rs775758080 0.8908 -2.187 0.959 D 0.766 0.908 0.879622353233 gnomAD-4.0.0 3.18177E-06 None None None None N None 0 4.5754E-05 None 0 0 None 0 0 0 0 0
V/I 2738 Ig-17 32 rs1340253990 0.0843 None 0.27 D 0.5 0.18 0.58895048698 gnomAD-4.0.0 1.59052E-06 None None None None N None 0 0 None 4.76554E-05 0 None 0 0 0 0 0
V/I 2825 Ig-18 31 rs776670775 0.0964 -0.637 0.997 D 0.629 0.341 0.64144316844 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/I 2825 Ig-18 31 rs776670775 0.0964 -0.637 0.997 D 0.629 0.341 0.64144316844 gnomAD-4.0.0 6.84067E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
V/L 2825 Ig-18 31 None 0.5439 None 0.997 D 0.66 0.445 0.660788651602 gnomAD-4.0.0 2.73627E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59717E-06 0 0
S/F 2912 Ig-19 31 None 0.8946 None 0.971 N 0.746 0.569 0.693576915185 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Y/C 2999 Ig-20 31 None 0.1825 None 1.0 D 0.781 0.657 0.72559337781 gnomAD-4.0.0 1.59063E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
V/E 3088 Ig-21 31 None 0.9914 None 0.942 D 0.785 0.834 0.86188130804 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 3088 Ig-21 31 rs776977480 0.1311 -0.487 0.656 D 0.565 0.327 0.613412721671 gnomAD-2.1.1 1.59E-05 None None None None N None 0 0 None 0 0 None 1.30659E-04 None 0 0 0
V/I 3088 Ig-21 31 rs776977480 0.1311 -0.487 0.656 D 0.565 0.327 0.613412721671 gnomAD-4.0.0 8.893E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99292E-07 1.04338E-04 4.96738E-05
A/D 3177 Ig-22 31 None 0.9581 None 0.801 N 0.801 0.586 0.688320708397 gnomAD-4.0.0 1.59067E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85662E-06 0 0
A/T 3177 Ig-22 31 None 0.2103 None 0.022 N 0.352 0.235 0.30212335484 gnomAD-4.0.0 2.40068E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62504E-06 0 0
I/M 3270 Ig-23 32 rs1447409995 0.2867 -0.808 0.901 D 0.697 0.472 0.651879210792 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.83E-06 0
I/T 3270 Ig-23 32 None 0.7874 None 0.722 D 0.716 0.603 0.74021432234 gnomAD-4.0.0 1.36815E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99302E-07 1.15934E-05 0
V/A 3375 Ig-24 31 rs2088242575 0.4259 None 0.174 D 0.608 0.533 0.680007063485 gnomAD-4.0.0 1.59095E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85709E-06 0 0
V/L 3375 Ig-24 31 None 0.3838 None 0.031 D 0.48 0.363 0.449572021084 gnomAD-4.0.0 1.36831E-06 None None None None I None 0 2.23634E-05 None 0 0 None 0 0 0 0 1.65601E-05
V/I 3691 Ig-26 32 rs1331719489 0.0849 -0.567 None None None 0.125 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
V/I 3691 Ig-26 32 rs1331719489 0.0849 -0.567 None None None 0.125 None gnomAD-4.0.0 1.59134E-06 None None None None N None 0 2.2877E-05 None 0 0 None 0 0 0 0 0
I/T 3851 Ig-27 32 None 0.6704 None 0.338 D 0.733 0.535 None gnomAD-4.0.0 5.47367E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59793E-06 4.63736E-05 0
V/I 3969 Ig-28 32 rs754991360 0.079 -0.668 0.006 N 0.206 0.101 None gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
V/I 3969 Ig-28 32 rs754991360 0.079 -0.668 0.006 N 0.206 0.101 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 3969 Ig-28 32 rs754991360 0.079 -0.668 0.006 N 0.206 0.101 None gnomAD-4.0.0 3.71813E-06 None None None None I None 0 0 None 0 0 None 0 0 5.08551E-06 0 0
V/L 3969 Ig-28 32 rs754991360 0.3474 None 0.114 D 0.506 0.24 None gnomAD-4.0.0 8.89428E-06 None None None None I None 0 0 None 0 0 None 0 0 1.16926E-05 0 0
V/A 4635 Ig-29 30 None 0.5169 None 0.977 D 0.579 0.685 None gnomAD-4.0.0 4.10548E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39683E-06 0 0
V/M 4635 Ig-29 30 None 0.4244 None 0.993 D 0.76 0.594 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 4826 Ig-31 32 rs1156737017 0.1057 -0.933 0.027 D 0.561 0.228 0.249502417897 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
T/A 4826 Ig-31 32 rs1156737017 0.1057 -0.933 0.027 D 0.561 0.228 0.249502417897 gnomAD-4.0.0 1.59125E-06 None None None None I None 0 0 None 0 2.77408E-05 None 0 0 0 0 0
T/N 4826 Ig-31 32 None 0.2783 None 0.741 D 0.649 0.376 0.508696012846 gnomAD-4.0.0 1.59124E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85814E-06 0 0
V/F 5199 Ig-35 32 rs1370452174 0.3604 None 1.0 D 0.801 0.623 0.904687970766 gnomAD-4.0.0 7.20193E-06 None None None None N None 0 0 None 0 0 None 0 0 7.87501E-06 0 0
P/L 5292 Ig-36 32 rs1394563400 0.1473 0.378 0.019 N 0.642 0.187 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
P/L 5292 Ig-36 32 rs1394563400 0.1473 0.378 0.019 N 0.642 0.187 None gnomAD-4.0.0 5.47363E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29628E-06 0 1.65656E-05
P/S 5292 Ig-36 32 None 0.1858 None 0.042 N 0.528 0.198 0.178374595973 gnomAD-4.0.0 6.84208E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99465E-07 0 0
P/T 5292 Ig-36 32 None 0.0986 None None N 0.389 0.124 0.253205268125 gnomAD-4.0.0 6.84208E-07 None None None None N None 0 0 None 0 2.51978E-05 None 0 0 0 0 0
V/L 5388 Ig-37 32 rs796743868 0.3997 -0.237 0.835 N 0.52 0.405 0.623711697247 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
V/L 5388 Ig-37 32 rs796743868 0.3997 -0.237 0.835 N 0.52 0.405 0.623711697247 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 0 4.79386E-04
V/L 5388 Ig-37 32 rs796743868 0.3997 -0.237 0.835 N 0.52 0.405 0.623711697247 gnomAD-4.0.0 6.57289E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 4.79386E-04
I/F 5481 Ig-38 32 None 0.2021 None 0.317 N 0.658 0.397 0.381239546501 gnomAD-4.0.0 1.59175E-06 None None None None N None 5.65483E-05 0 None 0 0 None 0 0 0 0 0
I/L 5575 Ig-39 33 rs1253223397 0.1712 -0.591 0.099 D 0.459 0.272 0.478980160563 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14837E-04 0 None 0 0 None 0 None 0 0 0
I/L 5575 Ig-39 33 rs1253223397 0.1712 -0.591 0.099 D 0.459 0.272 0.478980160563 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/L 5575 Ig-39 33 rs1253223397 0.1712 -0.591 0.099 D 0.459 0.272 0.478980160563 gnomAD-4.0.0 1.36841E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79894E-06 0 0
I/N 5668 Ig-40 32 None 0.4966 None 0.989 D 0.84 0.702 0.909692242837 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 5761 Ig-41 32 None 0.6634 None 0.78 D 0.636 0.686 0.760823172197 gnomAD-4.0.0 4.78995E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49747E-06 0 3.31367E-05
V/L 5761 Ig-41 32 None 0.4737 None 0.64 D 0.491 0.421 0.61844985043 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/D 5854 Ig-42 32 None 0.851 None 1.0 N 0.847 0.47 0.738729810274 gnomAD-4.0.0 1.36846E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 1.65673E-05
I/R 6043 Ig-44 32 rs1395649449 0.6502 -0.594 0.998 D 0.866 0.797 0.887689743602 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 5.65E-05 None 0 None 0 0 0
I/R 6043 Ig-44 32 rs1395649449 0.6502 -0.594 0.998 D 0.866 0.797 0.887689743602 gnomAD-4.0.0 1.5933E-06 None None None None N None 0 0 None 0 2.78412E-05 None 0 0 0 0 0
I/V 6043 Ig-44 32 rs1390946265 0.0762 -1.102 0.941 N 0.418 0.237 0.59028757549 gnomAD-2.1.1 1.8E-05 None None None None N None 0 0 None 0 5.2E-05 None 1.31605E-04 None 0 0 0
I/V 6043 Ig-44 32 rs1390946265 0.0762 -1.102 0.941 N 0.418 0.237 0.59028757549 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 1.93125E-04 None 0 0 0 2.06782E-04 0
I/V 6043 Ig-44 32 rs1390946265 0.0762 -1.102 0.941 N 0.418 0.237 0.59028757549 gnomAD-4.0.0 6.20014E-06 None None None None N None 0 0 None 0 2.23624E-05 None 0 0 1.69566E-06 6.59616E-05 1.60215E-05
V/A 6137 Ig-45 33 None 0.5015 None 0.334 D 0.654 0.636 0.685252170855 gnomAD-4.0.0 6.84258E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99493E-07 0 0
V/G 6137 Ig-45 33 None 0.6275 None 0.896 D 0.805 0.75 0.878149281796 gnomAD-4.0.0 6.84258E-07 None None None None N None 0 0 None 0 2.52143E-05 None 0 0 0 0 0
V/M 6137 Ig-45 33 None 0.3869 None 0.81 D 0.649 0.69 0.679255775376 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 6230 Ig-46 32 None 0.0934 None 0.543 N 0.203 0.217 0.532986417303 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/L 6323 Ig-47 32 rs2079899039 0.1454 None 0.004 D 0.399 0.084 0.424194796918 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/L 6323 Ig-47 32 rs2079899039 0.1454 None 0.004 D 0.399 0.084 0.424194796918 gnomAD-4.0.0 1.86043E-06 None None None None I None 2.67108E-05 0 None 0 0 None 0 0 0 0 1.60246E-05
V/G 6416 Ig-48 32 rs1431823102 0.5759 -2.376 0.971 D 0.859 0.772 0.933126727598 gnomAD-2.1.1 3.19E-05 None None None None N None 0 1.18203E-03 None 0 0 None 0 None 0 0 0
V/G 6416 Ig-48 32 rs1431823102 0.5759 -2.376 0.971 D 0.859 0.772 0.933126727598 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
V/G 6416 Ig-48 32 rs1431823102 0.5759 -2.376 0.971 D 0.859 0.772 0.933126727598 gnomAD-4.0.0 6.57333E-06 None None None None N None 0 6.55136E-05 None 0 0 None 0 0 0 0 0
A/S 6512 Ig-49 32 rs2079716781 0.1176 None 0.103 N 0.419 0.173 0.208000267992 gnomAD-4.0.0 1.36892E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79935E-06 0 0
A/V 6512 Ig-49 32 rs200902581 0.1362 -0.27 0.046 N 0.283 0.262 0.21279746466 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 1.30822E-04 None 0 0 0
A/V 6512 Ig-49 32 rs200902581 0.1362 -0.27 0.046 N 0.283 0.262 0.21279746466 gnomAD-4.0.0 6.16005E-06 None None None None N None 2.98954E-05 0 None 0 0 None 0 0 0 9.27773E-05 0
I/M 6605 Ig-50 32 None 0.1223 None 0.876 D 0.595 0.447 0.498830998431 gnomAD-4.0.0 1.20034E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
V/A 6699 Ig-51 33 rs907862282 0.3514 -1.795 0.714 D 0.625 0.62 0.721550138732 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 1.67429E-04 None 0 None 0 0 0
V/A 6699 Ig-51 33 rs907862282 0.3514 -1.795 0.714 D 0.625 0.62 0.721550138732 gnomAD-4.0.0 2.73795E-06 None None None None I None 0 0 None 0 7.56544E-05 None 0 0 8.99743E-07 0 0
V/D 6699 Ig-51 33 rs907862282 0.9752 -2.121 0.997 D 0.829 0.763 0.911773092726 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14969E-04 0 None 0 0 None 0 None 0 0 0
V/D 6699 Ig-51 33 rs907862282 0.9752 -2.121 0.997 D 0.829 0.763 0.911773092726 gnomAD-3.1.2 1.98E-05 None None None None I None 7.25E-05 0 0 0 0 None 0 0 0 0 0
V/D 6699 Ig-51 33 rs907862282 0.9752 -2.121 0.997 D 0.829 0.763 0.911773092726 gnomAD-4.0.0 3.72015E-06 None None None None I None 8.02096E-05 0 None 0 0 None 0 0 0 0 0
V/I 6699 Ig-51 33 None 0.1095 None 0.001 N 0.259 0.215 0.52090908611 gnomAD-4.0.0 1.59282E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86105E-06 0 0
V/I 6885 Ig-53 32 rs2079191317 0.0901 None 0.543 N 0.285 0.266 0.63713380425 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/I 6885 Ig-53 32 rs2079191317 0.0901 None 0.543 N 0.285 0.266 0.63713380425 gnomAD-4.0.0 6.57609E-06 None None None None N None 2.41394E-05 0 None 0 0 None 0 0 0 0 0
V/A 6979 Ig-54 32 None 0.1071 None 0.001 D 0.257 0.407 0.510466299808 gnomAD-4.0.0 1.5922E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86008E-06 0 0
V/F 6979 Ig-54 32 None 0.3392 None 0.627 D 0.745 0.523 0.782319092378 gnomAD-4.0.0 6.84378E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99648E-07 0 0
V/I 6979 Ig-54 32 rs768060617 0.109 0.601 0.001 N 0.335 0.132 0.314716216878 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
V/I 6979 Ig-54 32 rs768060617 0.109 0.601 0.001 N 0.335 0.132 0.314716216878 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 6979 Ig-54 32 rs768060617 0.109 0.601 0.001 N 0.335 0.132 0.314716216878 gnomAD-4.0.0 3.09916E-06 None None None None N None 0 0 None 0 0 None 0 0 4.23887E-06 0 0
V/L 6979 Ig-54 32 None 0.3202 None 0.033 D 0.518 0.341 0.340753184043 gnomAD-4.0.0 6.84378E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99648E-07 0 0
V/A 7168 Ig-56 32 None 0.4049 None 0.91 D 0.683 0.572 0.74991972993 gnomAD-4.0.0 1.3689E-06 None None None None N None 2.98989E-05 0 None 0 0 None 0 0 0 0 1.65788E-05
V/A 7354 Ig-58 32 rs1191619826 0.5779 None 0.78 D 0.706 0.663 None gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/A 7354 Ig-58 32 rs1191619826 0.5779 None 0.78 D 0.706 0.663 None gnomAD-4.0.0 6.57531E-06 None None None None I None 2.41394E-05 0 None 0 0 None 0 0 0 0 0
V/A 7450 Ig-59 32 None 0.4479 None 0.999 D 0.621 0.641 0.782002166855 gnomAD-4.0.0 2.05301E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69889E-06 0 0
V/L 7450 Ig-59 32 rs1195511070 0.367 -0.468 0.922 D 0.541 0.491 0.670247443365 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
V/L 7450 Ig-59 32 rs1195511070 0.367 -0.468 0.922 D 0.541 0.491 0.670247443365 gnomAD-4.0.0 3.1839E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.86607E-05 0
V/I 7640 Ig-61 33 rs1245374725 0.1003 None 0.001 N 0.232 0.186 0.416454006429 gnomAD-4.0.0 3.60097E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 2.625E-06 0 0
V/L 7640 Ig-61 33 rs1245374725 0.4958 -0.189 0.12 D 0.514 0.418 0.457013227636 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
V/A 7733 Ig-62 32 None 0.5674 None 0.999 D 0.653 0.848 0.820583082347 gnomAD-4.0.0 4.1063E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39781E-06 0 0
V/I 7733 Ig-62 32 rs1238420893 0.0982 None 0.434 N 0.294 0.262 0.581534369529 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
V/I 7733 Ig-62 32 rs1238420893 0.0982 None 0.434 N 0.294 0.262 0.581534369529 gnomAD-4.0.0 1.21793E-05 None None None None N None 0 0 None 0 0 None 0 0 1.32543E-05 0 3.40229E-05
V/A 7826 Ig-63 32 rs200663337 0.5892 -1.852 0.873 D 0.614 0.606 None gnomAD-2.1.1 6.43E-05 None None None None I None 0 2.83E-05 None 0 0 None 0 None 2.79799E-04 7.83E-05 0
V/A 7826 Ig-63 32 rs200663337 0.5892 -1.852 0.873 D 0.614 0.606 None gnomAD-3.1.2 4.6E-05 None None None None I None 2.41E-05 0 0 0 0 None 2.8238E-04 0 4.41E-05 0 0
V/A 7826 Ig-63 32 rs200663337 0.5892 -1.852 0.873 D 0.614 0.606 None gnomAD-4.0.0 7.74644E-05 None None None None I None 1.33504E-05 1.66694E-05 None 0 0 None 2.8118E-04 0 8.73069E-05 0 3.20246E-05
V/F 7826 Ig-63 32 rs746798612 0.6147 None 0.978 D 0.782 0.652 0.897645058709 gnomAD-4.0.0 7.52669E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99512E-06 0 1.65673E-05
V/I 7826 Ig-63 32 rs746798612 0.0899 -0.083 0.003 N 0.237 0.161 0.604919980721 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 1.30745E-04 None 0 0 0
V/I 7826 Ig-63 32 rs746798612 0.0899 -0.083 0.003 N 0.237 0.161 0.604919980721 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
V/I 7826 Ig-63 32 rs746798612 0.0899 -0.083 0.003 N 0.237 0.161 0.604919980721 gnomAD-4.0.0 7.43667E-06 None None None None I None 1.33504E-05 0 None 0 0 None 0 0 0 1.09806E-04 1.60128E-05
A/D 7920 Ig-64 32 None 0.6744 None 0.055 N 0.657 0.291 0.28492961333 gnomAD-4.0.0 1.36851E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79907E-06 0 0
A/T 7920 Ig-64 32 rs774246101 0.0737 -0.55 None N 0.283 0.095 0.110078149338 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
A/T 7920 Ig-64 32 rs774246101 0.0737 -0.55 None N 0.283 0.095 0.110078149338 gnomAD-4.0.0 1.59147E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85884E-06 0 0
A/V 7920 Ig-64 32 None 0.1027 None None N 0.281 0.097 0.101711395817 gnomAD-4.0.0 6.84257E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99533E-07 0 0
V/A 8016 Ig-65 32 rs746704436 0.1929 -1.502 0.939 D 0.635 0.642 0.742433623923 gnomAD-2.1.1 2.5E-05 None None None None I None 0 0 None 9.67E-05 5.12E-05 None 3.27E-05 None 0 3.13E-05 0
V/A 8016 Ig-65 32 rs746704436 0.1929 -1.502 0.939 D 0.635 0.642 0.742433623923 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.93798E-04 None 0 0 0 0 0
V/A 8016 Ig-65 32 rs746704436 0.1929 -1.502 0.939 D 0.635 0.642 0.742433623923 gnomAD-4.0.0 6.19722E-06 None None None None I None 1.33515E-05 0 None 0 2.22936E-05 None 0 0 5.08583E-06 1.09794E-05 1.60108E-05
V/L 8016 Ig-65 32 None 0.2983 None 0.76 D 0.556 0.456 0.53819168318 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
V/A 8109 Ig-66 32 None 0.4028 None 0.822 D 0.676 0.669 0.736644243634 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 8109 Ig-66 32 rs2077903400 0.1068 None 0.014 N 0.215 0.148 0.395143324098 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/I 8109 Ig-66 32 rs2077903400 0.1068 None 0.014 N 0.215 0.148 0.395143324098 gnomAD-4.0.0 2.56283E-06 None None None None I None 3.38455E-05 0 None 0 0 None 0 0 0 0 0
I/N 8295 Ig-68 32 rs752786293 0.9307 -1.373 0.965 D 0.845 0.658 0.899350334792 gnomAD-2.1.1 8.09E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
I/N 8295 Ig-68 32 rs752786293 0.9307 -1.373 0.965 D 0.845 0.658 0.899350334792 gnomAD-4.0.0 6.38857E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.73197E-05 0
V/G 8391 Ig-69 32 None 0.669 None 1.0 D 0.824 0.847 0.911112205665 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/V 8487 Ig-70 32 rs1368912492 0.1049 None None N 0.255 0.22 0.366085729538 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
V/F 8581 Ig-71 33 None 0.543 None 0.007 D 0.602 0.578 0.689457545739 gnomAD-4.0.0 6.84702E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99863E-07 0 0
V/I 8581 Ig-71 33 rs1014791707 0.0978 None None N 0.285 0.178 0.518092603711 gnomAD-4.0.0 3.42351E-06 None None None None N None 0 0 None 0 2.52309E-05 None 0 0 2.69959E-06 1.16198E-05 0
V/L 8581 Ig-71 33 rs1014791707 0.5144 -0.552 0.006 D 0.519 0.505 0.48286525802 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 5.63E-05 None 0 None 0 0 0
V/L 8581 Ig-71 33 rs1014791707 0.5144 -0.552 0.006 D 0.519 0.505 0.48286525802 gnomAD-4.0.0 1.36941E-06 None None None None N None 0 0 None 0 5.04643E-05 None 0 0 0 0 0
V/D 8674 Ig-72 32 None 0.9514 None 0.999 D 0.864 0.873 0.927335862034 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 8674 Ig-72 32 rs375710902 0.0742 -0.467 0.059 N 0.205 0.165 None gnomAD-2.1.1 2.14E-05 None None None None I None 2.06714E-04 0 None 0 5.12E-05 None 0 None 0 0 0
V/I 8674 Ig-72 32 rs375710902 0.0742 -0.467 0.059 N 0.205 0.165 None gnomAD-3.1.2 2.63E-05 None None None None I None 9.65E-05 0 0 0 0 None 0 0 0 0 0
V/I 8674 Ig-72 32 rs375710902 0.0742 -0.467 0.059 N 0.205 0.165 None gnomAD-4.0.0 6.81711E-06 None None None None I None 1.06812E-04 0 None 0 2.22777E-05 None 0 0 1.69531E-06 0 0
V/L 8674 Ig-72 32 None 0.3608 None 0.652 D 0.544 0.51 0.606491963429 gnomAD-4.0.0 1.36848E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99517E-07 1.1595E-05 0
T/A 8861 Ig-74 32 rs1432990460 0.0649 -1.095 0.001 N 0.238 0.131 0.115124310173 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
T/A 8861 Ig-74 32 rs1432990460 0.0649 -1.095 0.001 N 0.238 0.131 0.115124310173 gnomAD-4.0.0 1.59163E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85876E-06 0 0
T/S 8861 Ig-74 32 rs1419666616 0.145 -1.029 0.007 N 0.321 0.093 0.243398259712 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14916E-04 0 None 0 0 None 0 None 0 0 0
T/S 8861 Ig-74 32 rs1419666616 0.145 -1.029 0.007 N 0.321 0.093 0.243398259712 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
T/S 8861 Ig-74 32 rs1419666616 0.145 -1.029 0.007 N 0.321 0.093 0.243398259712 gnomAD-4.0.0 1.31473E-05 None None None None N None 4.82928E-05 0 None 0 0 None 0 0 0 0 0
V/I 8957 Ig-75 32 rs1008014872 0.0787 None 0.008 N 0.22 0.114 0.376921832658 gnomAD-3.1.2 4.6E-05 None None None None N None 1.69033E-04 0 0 0 0 None 0 0 0 0 0
V/I 8957 Ig-75 32 rs1008014872 0.0787 None 0.008 N 0.22 0.114 0.376921832658 gnomAD-4.0.0 5.58425E-06 None None None None N None 1.20218E-04 0 None 0 0 None 0 0 0 0 0
V/L 8957 Ig-75 32 None 0.3181 None 0.156 D 0.584 0.445 0.400899426204 gnomAD-4.0.0 6.85124E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00276E-07 0 0
V/F 9143 Ig-77 32 rs186857044 0.4274 -1.056 0.991 D 0.736 0.511 None gnomAD-2.1.1 1.16471E-04 None None None None N None 0 0 None 0 1.55902E-03 None 0 None 0 0 1.65618E-04
V/F 9143 Ig-77 32 rs186857044 0.4274 -1.056 0.991 D 0.736 0.511 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 5.79151E-04 None 0 0 0 0 0
V/F 9143 Ig-77 32 rs186857044 0.4274 -1.056 0.991 D 0.736 0.511 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
V/F 9143 Ig-77 32 rs186857044 0.4274 -1.056 0.991 D 0.736 0.511 None gnomAD-4.0.0 5.14329E-05 None None None None N None 0 0 None 0 1.82783E-03 None 0 0 0 0 1.60056E-05
V/L 9143 Ig-77 32 None 0.3958 None 0.863 D 0.643 0.482 0.522344865107 gnomAD-4.0.0 6.84207E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15937E-05 0
V/A 9236 Ig-78 32 rs1034794926 0.6561 None 0.978 D 0.613 0.661 0.768130985018 gnomAD-4.0.0 2.73685E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59788E-06 0 0
V/I 9236 Ig-78 32 rs774989128 0.076 -0.085 0.37 N 0.209 0.158 None gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
V/I 9236 Ig-78 32 rs774989128 0.076 -0.085 0.37 N 0.209 0.158 None gnomAD-4.0.0 6.84216E-06 None None None None I None 0 2.23664E-05 None 0 0 None 0 0 8.09529E-06 0 0
V/M 9332 Ig-79 32 rs367734747 0.4444 -0.552 1.0 None 0.787 0.515 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/M 9332 Ig-79 32 rs367734747 0.4444 -0.552 1.0 None 0.787 0.515 None gnomAD-4.0.0 4.33785E-06 None None None None N None 0 0 None 0 2.22816E-05 None 0 0 5.08557E-06 0 0
V/F 9428 Ig-80 32 None 0.2945 None 0.942 None 0.735 0.512 0.882498648049 gnomAD-4.0.0 5.47328E-06 None None None None I None 0 0 None 0 0 None 0 0 7.1954E-06 0 0
V/I 9428 Ig-80 32 rs1284963573 0.0884 -0.293 0.014 None 0.203 0.184 0.445811967706 gnomAD-2.1.1 8.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.77E-05 0
V/I 9428 Ig-80 32 rs1284963573 0.0884 -0.293 0.014 None 0.203 0.184 0.445811967706 gnomAD-4.0.0 4.78912E-06 None None None None I None 0 0 None 0 0 None 0 1.7337E-04 3.5977E-06 1.15931E-05 1.65634E-05
V/L 9428 Ig-80 32 rs1284963573 0.3002 -0.295 0.014 None 0.331 0.343 0.448099371145 gnomAD-2.1.1 3.18E-05 None None None None I None 1.14732E-04 0 None 0 0 None 0 None 0 0 0
V/L 9428 Ig-80 32 rs1284963573 0.3002 -0.295 0.014 None 0.331 0.343 0.448099371145 gnomAD-3.1.2 1.31E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
V/L 9428 Ig-80 32 rs1284963573 0.3002 -0.295 0.014 None 0.331 0.343 0.448099371145 gnomAD-4.0.0 1.31449E-05 None None None None I None 4.82649E-05 0 None 0 0 None 0 0 0 0 0
I/N 9621 Ig-82 32 None 0.9626 None 0.994 None 0.856 0.785 0.909067042513 gnomAD-4.0.0 1.59103E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85776E-06 0 0
V/F 9729 Ig-83 32 rs1060500451 0.9395 None 1.0 None 0.791 0.472 0.899764585955 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
V/F 9729 Ig-83 32 rs1060500451 0.9395 None 1.0 None 0.791 0.472 0.899764585955 gnomAD-4.0.0 1.23966E-06 None None None None I None 0 3.33433E-05 None 0 0 None 0 0 0 0 0
V/I 9729 Ig-83 32 rs1060500451 0.1659 None 0.997 None 0.631 0.403 0.694113019094 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 9729 Ig-83 32 rs1060500451 0.1659 None 0.997 None 0.631 0.403 0.694113019094 gnomAD-4.0.0 1.17768E-05 None None None None I None 0 0 None 0 0 None 0 0 1.61082E-05 0 0
L/I 9932 Ig-84 33 rs753689443 0.4291 -1.109 0.999 None 0.511 0.277 0.595953376904 gnomAD-2.1.1 4.08E-06 None None None None I None 0 0 None 0 5.66E-05 None 0 None 0 0 0
L/I 9932 Ig-84 33 rs753689443 0.4291 -1.109 0.999 None 0.511 0.277 0.595953376904 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92604E-04 None 0 0 0 0 0
L/P 9932 Ig-84 33 rs1300557715 0.9552 -1.586 1.0 None 0.823 0.775 0.840140036523 gnomAD-2.1.1 1.22E-05 None None None None I None 0 8.8E-05 None 0 0 None 0 None 0 0 0
L/P 9932 Ig-84 33 rs1300557715 0.9552 -1.586 1.0 None 0.823 0.775 0.840140036523 gnomAD-4.0.0 4.78761E-06 None None None None I None 0 6.89592E-05 None 0 0 None 0 0 0 0 0
S/A 10019 Ig-85 31 rs754368714 0.1602 -0.496 0.01 None 0.235 0.101 None gnomAD-2.1.1 1.78E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.11E-05 1.40056E-04
S/A 10019 Ig-85 31 rs754368714 0.1602 -0.496 0.01 None 0.235 0.101 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 4.77555E-04
S/A 10019 Ig-85 31 rs754368714 0.1602 -0.496 0.01 None 0.235 0.101 None gnomAD-4.0.0 2.10681E-05 None None None None N None 1.33504E-05 0 None 0 0 None 0 0 2.62738E-05 0 3.20164E-05
S/C 10019 Ig-85 31 None 0.2979 None 0.993 None 0.688 0.412 0.412458657427 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/P 10019 Ig-85 31 rs754368714 0.8102 -0.293 0.006 None 0.391 0.298 0.218112801441 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/P 10019 Ig-85 31 rs754368714 0.8102 -0.293 0.006 None 0.391 0.298 0.218112801441 gnomAD-4.0.0 6.84135E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
T/I 13717 Ig-87 34 rs754753030 0.8906 0.387 1.0 N 0.772 0.421 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
V/A 13810 Ig-88 31 rs1167247967 0.67 -1.733 0.996 N 0.553 0.341 0.434934176536 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
V/A 13810 Ig-88 31 rs1167247967 0.67 -1.733 0.996 N 0.553 0.341 0.434934176536 gnomAD-4.0.0 3.18564E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72115E-06 0 0
V/L 13810 Ig-88 31 None 0.8253 None 0.992 N 0.411 0.308 0.416328079214 gnomAD-4.0.0 6.84494E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99696E-07 0 0
V/M 13810 Ig-88 31 rs763668057 0.7308 -0.477 0.997 N 0.345 0.363 0.416202232284 gnomAD-2.1.1 2.42E-05 None None None None N None 0 8.71E-05 None 0 0 None 0 None 0 1.78E-05 1.66058E-04
V/M 13810 Ig-88 31 rs763668057 0.7308 -0.477 0.997 N 0.345 0.363 0.416202232284 gnomAD-3.1.2 1.32E-05 None None None None N None 2.41E-05 6.56E-05 0 0 0 None 0 0 0 0 0
V/M 13810 Ig-88 31 rs763668057 0.7308 -0.477 0.997 N 0.345 0.363 0.416202232284 gnomAD-4.0.0 4.15381E-05 None None None None N None 1.33554E-05 6.67134E-05 None 0 2.24014E-05 None 0 0 5.00223E-05 0 3.20379E-05
V/A 14172 Ig-92 31 rs2060117158 0.4543 None 0.002 D 0.349 0.413 0.616247408722 gnomAD-4.0.0 3.18409E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72001E-06 0 0
V/L 14172 Ig-92 31 rs748615976 0.4453 -0.879 0.002 D 0.337 0.365 0.53586618445 gnomAD-2.1.1 8.05E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
V/L 14172 Ig-92 31 rs748615976 0.4453 -0.879 0.002 D 0.337 0.365 0.53586618445 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.57E-05 0 0 0 None 0 0 0 0 0
V/L 14172 Ig-92 31 rs748615976 0.4453 -0.879 0.002 D 0.337 0.365 0.53586618445 gnomAD-4.0.0 3.84564E-06 None None None None N None 0 5.08854E-05 None 0 0 None 0 0 0 0 0
G/D 14349 Ig-94 31 rs1211758299 0.9656 None 0.993 D 0.81 0.333 0.202949470691 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/D 14349 Ig-94 31 rs1211758299 0.9656 None 0.993 D 0.81 0.333 0.202949470691 gnomAD-4.0.0 6.57445E-06 None None None None I None 0 0 None 0 0 None 0 0 1.4708E-05 0 0
G/S 14349 Ig-94 31 rs781452930 0.351 -0.914 0.982 N 0.579 0.246 None gnomAD-2.1.1 3.22E-05 None None None None I None 0 1.16218E-04 None 0 5.61E-05 None 0 None 0 2.67E-05 0
G/S 14349 Ig-94 31 rs781452930 0.351 -0.914 0.982 N 0.579 0.246 None gnomAD-3.1.2 3.29E-05 None None None None I None 0 1.31062E-04 0 0 0 None 0 0 4.41E-05 0 0
G/S 14349 Ig-94 31 rs781452930 0.351 -0.914 0.982 N 0.579 0.246 None gnomAD-4.0.0 3.16172E-05 None None None None I None 0 1.1676E-04 None 0 0 None 0 0 3.30656E-05 4.39348E-05 1.60195E-05
V/I 14527 Ig-96 31 rs1358591664 0.1656 -0.73 0.997 D 0.537 0.424 0.717526509295 gnomAD-2.1.1 7.39E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.1E-06 1.43885E-04
V/I 14527 Ig-96 31 rs1358591664 0.1656 -0.73 0.997 D 0.537 0.424 0.717526509295 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 14527 Ig-96 31 rs1358591664 0.1656 -0.73 0.997 D 0.537 0.424 0.717526509295 gnomAD-4.0.0 6.21792E-06 None None None None N None 0 0 None 0 0 None 0 0 7.64474E-06 0 1.60612E-05
V/A 14616 Ig-97 31 None 0.4967 None 0.999 D 0.61 0.794 0.780250927539 gnomAD-4.0.0 6.16008E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29729E-06 0 3.31576E-05
A/D 14705 Ig-98 31 None 0.9164 None 0.981 N 0.824 0.244 0.265010934533 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/S 14705 Ig-98 31 None 0.2012 None 0.947 N 0.553 0.204 0.149567049428 gnomAD-4.0.0 6.84425E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99709E-07 0 0
A/T 14705 Ig-98 31 rs751017081 0.2933 -1.1 0.996 N 0.677 0.282 None gnomAD-2.1.1 1.78E-05 None None None None N None 1.24008E-04 5.66E-05 None 0 0 None 0 None 0 0 0
A/T 14705 Ig-98 31 rs751017081 0.2933 -1.1 0.996 N 0.677 0.282 None gnomAD-3.1.2 3.29E-05 None None None None N None 1.20639E-04 0 0 0 0 None 0 0 0 0 0
A/T 14705 Ig-98 31 rs751017081 0.2933 -1.1 0.996 N 0.677 0.282 None gnomAD-4.0.0 7.43877E-06 None None None None N None 1.06832E-04 3.33556E-05 None 0 2.23155E-05 None 0 0 8.47836E-07 0 0
V/G 14794 Ig-99 30 rs779834438 0.6307 -2.645 1.0 N 0.856 0.676 0.815322740875 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/G 14794 Ig-99 30 rs779834438 0.6307 -2.645 1.0 N 0.856 0.676 0.815322740875 gnomAD-4.0.0 2.73842E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.63876E-05 0
V/A 14883 Ig-100 31 None 0.8466 None 0.999 D 0.603 0.704 0.787503885549 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/L 14883 Ig-100 31 rs1175129824 0.8859 -0.477 0.997 D 0.629 0.579 0.775077876068 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/M 14883 Ig-100 31 None 0.8656 None 1.0 D 0.756 0.591 0.801802706094 gnomAD-4.0.0 1.59376E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86272E-06 0 0
V/F 14972 Ig-101 31 None 0.5735 None 0.991 D 0.729 0.592 0.809165052584 gnomAD-4.0.0 6.90004E-07 None None None None N None 0 0 None 0 2.55337E-05 None 0 0 0 0 0
V/I 14972 Ig-101 31 None 0.1403 None 0.863 D 0.547 0.314 0.620746667299 gnomAD-4.0.0 6.90004E-07 None None None None N None 0 0 None 0 0 None 0 0 9.04743E-07 0 0
V/G 15061 Ig-102 31 None 0.5176 None 1.0 D 0.837 0.744 0.941024214575 gnomAD-4.0.0 1.5938E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86269E-06 0 0
V/I 15150 Ig-103 31 rs1395618626 0.1274 -0.439 0.997 D 0.595 0.399 0.638950937581 gnomAD-2.1.1 1.08E-05 None None None None N None 1.24244E-04 0 None 0 0 None 0 None 0 0 0
V/I 15150 Ig-103 31 rs1395618626 0.1274 -0.439 0.997 D 0.595 0.399 0.638950937581 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
V/I 15150 Ig-103 31 rs1395618626 0.1274 -0.439 0.997 D 0.595 0.399 0.638950937581 gnomAD-4.0.0 5.13448E-06 None None None None N None 6.77805E-05 0 None 0 0 None 0 0 0 0 0
L/M 15332 Ig-105 31 None 0.3116 None 0.997 N 0.745 0.253 0.584212540733 gnomAD-4.0.0 6.84812E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00037E-07 0 0
L/P 15332 Ig-105 31 None 0.9373 None 0.999 N 0.818 0.77 0.885213830694 gnomAD-4.0.0 1.3696E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80004E-06 0 0
V/I 15421 Ig-106 31 rs1182471718 0.1076 -0.636 0.248 N 0.329 0.227 0.636377056752 gnomAD-2.1.1 5.26E-06 None None None None N None 0 4.18E-05 None 0 0 None 0 None 0 0 0
V/I 15421 Ig-106 31 rs1182471718 0.1076 -0.636 0.248 N 0.329 0.227 0.636377056752 gnomAD-4.0.0 1.79914E-06 None None None None N None 0 3.12656E-05 None 0 0 None 0 0 0 0 0
V/L 15510 Ig-107 31 rs754751783 0.7542 -0.295 0.997 D 0.565 0.552 0.643851019634 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
V/L 15510 Ig-107 31 rs754751783 0.7542 -0.295 0.997 D 0.565 0.552 0.643851019634 gnomAD-4.0.0 3.18814E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72816E-06 0 0
I/V 16290 Ig-110 29 rs778793317 0.1118 -1.251 0.001 N 0.224 0.054 0.269558022972 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 5.65E-05 None 0 None 0 1.79E-05 0
I/V 16290 Ig-110 29 rs778793317 0.1118 -1.251 0.001 N 0.224 0.054 0.269558022972 gnomAD-4.0.0 7.97067E-06 None None None None I None 0 0 None 0 2.79049E-05 None 0 0 1.14509E-05 0 0
I/T 17279 Ig-112 29 None 0.7165 None 0.722 D 0.712 0.667 0.839211880287 gnomAD-4.0.0 3.18798E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72551E-06 0 0
K/E 17704 Ig-113 28 None 0.2666 None 0.042 N 0.497 0.115 None gnomAD-4.0.0 4.10637E-06 None None None None I None 0 0 None 0 0 None 0 0 5.39823E-06 0 0
I/M 17998 Ig-114 31 None 0.1371 None 0.998 N 0.683 0.462 0.55350970329 gnomAD-4.0.0 1.59424E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8629E-06 0 0
I/T 17998 Ig-114 31 rs781376870 0.4092 -2.152 0.989 N 0.762 0.72 0.791155293085 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.98E-06 0
I/T 17998 Ig-114 31 rs781376870 0.4092 -2.152 0.989 N 0.762 0.72 0.791155293085 gnomAD-3.1.2 6.59E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 17998 Ig-114 31 rs781376870 0.4092 -2.152 0.989 N 0.762 0.72 0.791155293085 gnomAD-4.0.0 8.06347E-06 None None None None I None 0 0 None 0 2.24245E-05 None 0 0 7.63282E-06 3.29649E-05 0
S/L 18410 Ig-115 29 rs1184146630 0.1001 0.299 0.101 N 0.671 0.28 0.413761986042 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
S/L 18410 Ig-115 29 rs1184146630 0.1001 0.299 0.101 N 0.671 0.28 0.413761986042 gnomAD-4.0.0 1.5933E-06 None None None None N None 0 2.28791E-05 None 0 0 None 0 0 0 0 0
S/P 18410 Ig-115 29 rs778636992 0.279 -0.667 0.523 N 0.659 0.254 0.272639205421 gnomAD-2.1.1 1.21E-05 None None None None N None 0 8.7E-05 None 0 0 None 0 None 0 0 0
S/P 18410 Ig-115 29 rs778636992 0.279 -0.667 0.523 N 0.659 0.254 0.272639205421 gnomAD-3.1.2 6.59E-06 None None None None N None 0 6.57E-05 0 0 0 None 0 0 0 0 0
S/P 18410 Ig-115 29 rs778636992 0.279 -0.667 0.523 N 0.659 0.254 0.272639205421 gnomAD-4.0.0 5.13206E-06 None None None None N None 0 6.78817E-05 None 0 0 None 0 0 0 0 0
L/V 18716 Ig-116 29 rs1216121898 0.0935 None 0.999 N 0.625 0.243 0.403896168776 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/V 18716 Ig-116 29 rs1216121898 0.0935 None 0.999 N 0.625 0.243 0.403896168776 gnomAD-4.0.0 2.5658E-06 None None None None I None 0 0 None 0 0 None 0 0 4.79209E-06 0 0
V/A 19124 Ig-117 30 None 0.4267 None 0.517 D 0.623 0.571 0.557325494615 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 19124 Ig-117 30 rs142841000 0.0662 -0.468 0.019 N 0.205 0.09 None gnomAD-2.1.1 1.71905E-04 None None None None I None 1.73625E-03 2.83E-05 None 0 0 None 3.27E-05 None 0 3.14E-05 0
V/I 19124 Ig-117 30 rs142841000 0.0662 -0.468 0.019 N 0.205 0.09 None gnomAD-3.1.2 4.67222E-04 None None None None I None 1.64315E-03 6.56E-05 0 0 0 None 0 0 2.94E-05 0 0
V/I 19124 Ig-117 30 rs142841000 0.0662 -0.468 0.019 N 0.205 0.09 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
V/I 19124 Ig-117 30 rs142841000 0.0662 -0.468 0.019 N 0.205 0.09 None gnomAD-4.0.0 7.93434E-05 None None None None I None 1.36083E-03 5.00467E-05 None 0 0 None 0 0 9.32556E-06 6.58979E-05 9.60676E-05
V/A 19418 Ig-118 28 rs1236311809 0.385 None 0.22 D 0.648 0.53 0.610564787575 gnomAD-4.0.0 4.77625E-06 None None None None I None 1.69722E-04 0 None 0 0 None 0 0 0 0 0
V/G 19418 Ig-118 28 rs1236311809 0.6191 -2.228 0.667 D 0.855 0.624 0.799865847574 gnomAD-2.1.1 6.38E-05 None None None None I None 2.29568E-04 0 None 0 0 None 0 None 0 0 0
V/G 19418 Ig-118 28 rs1236311809 0.6191 -2.228 0.667 D 0.855 0.624 0.799865847574 gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
V/G 19418 Ig-118 28 rs1236311809 0.6191 -2.228 0.667 D 0.855 0.624 0.799865847574 gnomAD-4.0.0 3.84536E-06 None None None None I None 5.07511E-05 0 None 0 0 None 0 0 0 0 0
V/I 19418 Ig-118 28 rs2050889894 0.0796 None None N 0.189 0.167 0.251639045875 gnomAD-4.0.0 6.84362E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9957E-07 0 0
V/L 19418 Ig-118 28 None 0.3353 None 0.001 D 0.325 0.199 0.384419519794 gnomAD-4.0.0 6.84362E-07 None None None None I None 0 0 None 0 0 None 0 0 8.9957E-07 0 0
V/G 19818 Ig-119 29 rs1371676567 0.7463 -2.593 1.0 D 0.878 0.836 0.884655929374 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
A/G 20110 Ig-120 31 None 0.2505 None 0.787 N 0.669 0.189 0.336155897331 gnomAD-4.0.0 4.78042E-06 None None None None I None 0 0 None 0 0 None 0 0 8.58512E-06 0 0
I/V 20508 Ig-121 30 None 0.0889 None 0.046 N 0.211 0.088 0.382925413656 gnomAD-4.0.0 4.80129E-06 None None None None I None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
V/A 20801 Ig-122 33 None 0.5769 None 0.939 D 0.639 0.631 0.750989448909 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
V/I 20801 Ig-122 33 None 0.0783 None 0.046 N 0.205 0.208 0.510230903827 gnomAD-4.0.0 6.84629E-07 None None None None N None 0 0 None 0 2.52309E-05 None 0 0 0 0 0
V/L 20801 Ig-122 33 None 0.4801 None 0.76 D 0.563 0.492 0.636647316547 gnomAD-4.0.0 6.84629E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99931E-07 0 0
V/A 21206 Ig-123 30 rs370145029 0.452 -1.768 0.977 D 0.64 0.688 None gnomAD-2.1.1 2.15E-05 None None None None I None 2.48262E-04 0 None 0 0 None 0 None 0 0 0
V/A 21206 Ig-123 30 rs370145029 0.452 -1.768 0.977 D 0.64 0.688 None gnomAD-3.1.2 5.27E-05 None None None None I None 1.93274E-04 0 0 0 0 None 0 0 0 0 0
V/A 21206 Ig-123 30 rs370145029 0.452 -1.768 0.977 D 0.64 0.688 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
V/A 21206 Ig-123 30 rs370145029 0.452 -1.768 0.977 D 0.64 0.688 None gnomAD-4.0.0 8.68012E-06 None None None None I None 1.73463E-04 0 None 0 0 None 0 0 0 0 1.60185E-05
V/D 21206 Ig-123 30 None 0.9356 None 0.999 D 0.867 0.88 0.92510636424 gnomAD-4.0.0 6.84545E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99732E-07 0 0
V/I 21206 Ig-123 30 None 0.0941 None 0.117 N 0.315 0.168 0.601658297244 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
C/Y 21498 Ig-124 30 rs752724337 0.543 -1.732 0.989 N 0.847 0.357 0.697263286892 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 1.65893E-04
C/Y 21498 Ig-124 30 rs752724337 0.543 -1.732 0.989 N 0.847 0.357 0.697263286892 gnomAD-4.0.0 1.59235E-05 None None None None N None 0 0 None 0 2.49723E-04 None 0 2.41663E-04 0 0 0
V/L 21895 Ig-125 30 None 0.3426 None 0.031 D 0.461 0.188 0.445007932271 gnomAD-4.0.0 1.59553E-06 None None None None N None 0 0 None 0 0 None 0 0 2.865E-06 0 0
I/T 22293 Ig-126 29 rs766138542 0.8195 -2.001 0.92 N 0.633 0.621 0.745045780685 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.62E-05 None 0 None 0 0 0
I/T 22293 Ig-126 29 rs766138542 0.8195 -2.001 0.92 N 0.633 0.621 0.745045780685 gnomAD-4.0.0 1.59312E-06 None None None None I None 0 0 None 0 2.78489E-05 None 0 0 0 0 0
V/A 22582 Ig-127 23 None 0.3309 None 0.034 D 0.376 0.464 0.529661991002 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
M/I 24061 Ig-131 33 None 0.3624 None 0.001 N 0.271 0.153 0.228597637076 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
M/T 24061 Ig-131 33 rs200471370 0.3129 -1.528 0.425 N 0.567 0.397 None gnomAD-2.1.1 1.35953E-04 None None None None N None 1.65549E-04 0 None 0 0 None 0 None 0 2.58378E-04 1.40687E-04
M/T 24061 Ig-131 33 rs200471370 0.3129 -1.528 0.425 N 0.567 0.397 None gnomAD-3.1.2 1.31631E-04 None None None None N None 4.83E-05 0 0 0 0 None 0 0 2.50103E-04 0 4.78469E-04
M/T 24061 Ig-131 33 rs200471370 0.3129 -1.528 0.425 N 0.567 0.397 None gnomAD-4.0.0 2.91985E-04 None None None None N None 6.68235E-05 1.66783E-05 None 0 0 None 0 0 3.39957E-04 0 1.02498E-03
M/V 24061 Ig-131 33 rs201482015 0.0814 -1.315 0.065 N 0.343 0.148 None gnomAD-2.1.1 1.0732E-04 None None None None N None 1.19973E-03 0 None 0 0 None 0 None 0 0 1.40687E-04
M/V 24061 Ig-131 33 rs201482015 0.0814 -1.315 0.065 N 0.343 0.148 None gnomAD-3.1.2 3.87908E-04 None None None None N None 1.39941E-03 6.55E-05 0 0 0 None 0 0 0 0 0
M/V 24061 Ig-131 33 rs201482015 0.0814 -1.315 0.065 N 0.343 0.148 None 1000 genomes 3.99361E-04 None None None None N None 1.5E-03 0 None None 0 0 None None None 0 None
M/V 24061 Ig-131 33 rs201482015 0.0814 -1.315 0.065 N 0.343 0.148 None gnomAD-4.0.0 7.87176E-05 None None None None N None 1.4796E-03 5.001E-05 None 0 0 None 0 0 3.39108E-06 0 1.44083E-04
V/A 24460 Ig-132 30 None 0.4123 None 0.892 D 0.585 0.615 None gnomAD-4.0.0 6.36738E-06 None None None None I None 0 0 None 0 0 None 0 0 1.14375E-05 0 0
V/L 24460 Ig-132 30 None 0.5934 None 0.369 D 0.559 0.534 0.526995340713 gnomAD-4.0.0 1.36862E-06 None None None None I None 2.98972E-05 0 None 0 0 None 0 0 8.9958E-07 0 0
V/M 24460 Ig-132 30 rs546803158 0.437 -0.461 0.967 D 0.706 0.674 0.652220884204 gnomAD-2.1.1 6.85E-05 None None None None I None 0 8.7E-05 None 0 0 None 3.59524E-04 None 0 1.78E-05 1.65948E-04
V/M 24460 Ig-132 30 rs546803158 0.437 -0.461 0.967 D 0.706 0.674 0.652220884204 gnomAD-3.1.2 3.95E-05 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 8.29187E-04 4.77555E-04
V/M 24460 Ig-132 30 rs546803158 0.437 -0.461 0.967 D 0.706 0.674 0.652220884204 1000 genomes 5.99042E-04 None None None None I None 0 0 None None 0 0 None None None 3.1E-03 None
V/M 24460 Ig-132 30 rs546803158 0.437 -0.461 0.967 D 0.706 0.674 0.652220884204 gnomAD-4.0.0 2.97488E-05 None None None None I None 0 3.33378E-05 None 0 0 None 0 0 1.35638E-05 2.85507E-04 6.40287E-05
V/A 24747 Ig-133 32 None 0.233 None 0.007 D 0.289 0.465 0.51081628273 gnomAD-4.0.0 2.05306E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79922E-06 1.15947E-05 0
V/G 24747 Ig-133 32 None 0.4807 None 0.549 D 0.779 0.649 0.858287464937 gnomAD-4.0.0 6.84353E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99612E-07 0 0
V/I 24747 Ig-133 32 rs776245661 0.0785 0.007 0.002 N 0.268 0.143 0.3571064206 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
V/I 24747 Ig-133 32 rs776245661 0.0785 0.007 0.002 N 0.268 0.143 0.3571064206 gnomAD-4.0.0 6.84351E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99601E-06 0 0
I/T 25143 Ig-134 33 rs988443056 0.1855 None None N 0.385 0.198 0.567207890759 gnomAD-4.0.0 1.59168E-06 None None None None N None 0 0 None 0 0 None 0 2.41313E-04 0 0 0
V/F 25542 Ig-135 29 rs771230325 0.5705 None 0.998 D 0.767 0.64 0.809660090653 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/F 25542 Ig-135 29 rs771230325 0.5705 None 0.998 D 0.767 0.64 0.809660090653 gnomAD-4.0.0 1.2403E-06 None None None None N None 0 0 None 0 0 None 0 0 8.48139E-07 1.09912E-05 0
V/I 25542 Ig-135 29 None 0.0909 -0.35 0.543 N 0.221 0.215 0.470890129789 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 6.56E-05 None 0 0 0
V/I 25542 Ig-135 29 None 0.0909 -0.35 0.543 N 0.221 0.215 0.470890129789 gnomAD-4.0.0 4.10833E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.80302E-05 1.65793E-05
I/M 26225 Ig-137 33 None 0.1159 None 0.164 N 0.429 0.34 0.418344901717 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
I/N 26225 Ig-137 33 None 0.835 None 0.979 D 0.802 0.752 0.877426635404 gnomAD-4.0.0 6.8458E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99776E-07 0 0
I/T 26225 Ig-137 33 rs12463674 0.2306 -1.944 0.684 N 0.651 0.438 None gnomAD-2.1.1 2.34287E-01 None None None None N None 4.86473E-02 1.11736E-01 None 2.0979E-01 4.55621E-02 None 2.20055E-01 None 3.83921E-01 3.0754E-01 2.45344E-01
I/T 26225 Ig-137 33 rs12463674 0.2306 -1.944 0.684 N 0.651 0.438 None gnomAD-3.1.2 2.14052E-01 None None None None N None 5.38053E-02 1.52639E-01 2.2467E-01 2.10208E-01 5.20712E-02 None 3.86338E-01 2.40506E-01 3.10594E-01 2.24502E-01 2.02586E-01
I/T 26225 Ig-137 33 rs12463674 0.2306 -1.944 0.684 N 0.651 0.438 None 1000 genomes 1.29992E-01 None None None None N None 5.3E-03 1.124E-01 None None 4.27E-02 3.091E-01 None None None 2.168E-01 None
I/T 26225 Ig-137 33 rs12463674 0.2306 -1.944 0.684 N 0.651 0.438 None gnomAD-4.0.0 2.78864E-01 None None None None N None 4.83118E-02 1.22988E-01 None 2.11636E-01 4.99732E-02 None 3.79029E-01 2.10152E-01 3.12313E-01 2.23054E-01 2.5571E-01
I/N 26624 Ig-138 31 rs373540030 0.7346 -2.455 0.994 D 0.846 0.709 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/N 26624 Ig-138 31 rs373540030 0.7346 -2.455 0.994 D 0.846 0.709 None gnomAD-4.0.0 4.78978E-06 None None None None N None 0 0 None 0 0 None 0 0 0 8.11575E-05 0
I/S 26624 Ig-138 31 None 0.722 None 0.983 D 0.837 0.72 0.914779128301 gnomAD-4.0.0 6.84254E-07 None None None None N None 0 0 None 0 0 None 0 1.73551E-04 0 0 0
I/T 26624 Ig-138 31 rs373540030 0.6145 -2.757 0.892 D 0.786 0.642 0.799861211108 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.8E-05 None 0 0 0
I/T 26624 Ig-138 31 rs373540030 0.6145 -2.757 0.892 D 0.786 0.642 0.799861211108 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/T 26624 Ig-138 31 rs373540030 0.6145 -2.757 0.892 D 0.786 0.642 0.799861211108 gnomAD-4.0.0 4.95808E-06 None None None None N None 1.33522E-05 0 None 0 0 None 0 1.64528E-04 8.47677E-07 5.48944E-05 0
I/M 26911 Ig-139 32 rs371965190 0.1775 -0.661 0.782 D 0.699 0.463 None gnomAD-2.1.1 1.43E-05 None None None None N None 1.65412E-04 0 None 0 0 None 0 None 0 0 0
I/M 26911 Ig-139 32 rs371965190 0.1775 -0.661 0.782 D 0.699 0.463 None gnomAD-3.1.2 3.94E-05 None None None None N None 1.44802E-04 0 0 0 0 None 0 0 0 0 0
I/M 26911 Ig-139 32 rs371965190 0.1775 -0.661 0.782 D 0.699 0.463 None gnomAD-4.0.0 9.29593E-06 None None None None N None 1.86632E-04 0 None 0 0 None 0 0 0 1.09803E-05 0
I/V 26911 Ig-139 32 rs1017295644 0.0694 None None N 0.282 0.18 0.159798565429 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
V/A 27307 Ig-140 30 rs760826563 0.1523 -2.015 0.104 D 0.665 0.427 0.619546946635 gnomAD-4.0.0 1.3686E-06 None None None None N None 0 0 None 0 2.51953E-05 None 0 0 8.99463E-07 0 0
V/D 27307 Ig-140 30 None 0.7036 None 0.667 D 0.868 0.652 0.869592272605 gnomAD-4.0.0 6.843E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99463E-07 0 0
V/G 27707 Ig-141 32 rs771940719 0.5894 -2.395 0.999 D 0.87 0.752 0.919593144702 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 9.95E-05 0 None 0 None 0 0 0
V/G 27707 Ig-141 32 rs771940719 0.5894 -2.395 0.999 D 0.87 0.752 0.919593144702 gnomAD-4.0.0 1.5915E-06 None None None None N None 0 0 None 4.76781E-05 0 None 0 0 0 0 0
V/I 27707 Ig-141 32 None 0.1102 None 0.117 N 0.295 0.22 0.500931478032 gnomAD-4.0.0 1.59148E-06 None None None None N None 5.65675E-05 0 None 0 0 None 0 0 0 0 0
V/L 27994 Ig-142 32 None 0.2392 None 0.068 D 0.61 0.309 0.372268306217 gnomAD-4.0.0 3.18557E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72001E-06 0 0
V/M 27994 Ig-142 32 rs572706568 0.1876 -0.467 0.782 D 0.699 0.439 0.485634191555 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.93125E-04 None 0 0 0 0 0
V/M 27994 Ig-142 32 rs572706568 0.1876 -0.467 0.782 D 0.699 0.439 0.485634191555 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
V/M 27994 Ig-142 32 rs572706568 0.1876 -0.467 0.782 D 0.699 0.439 0.485634191555 gnomAD-4.0.0 6.56711E-06 None None None None N None 0 0 None 0 1.93573E-04 None 0 0 0 0 0
I/T 28389 Ig-143 32 rs755134776 0.2835 -2.271 0.062 N 0.641 0.515 0.693152146671 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.66113E-04
I/T 28389 Ig-143 32 rs755134776 0.2835 -2.271 0.062 N 0.641 0.515 0.693152146671 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
V/A 28786 Ig-144 32 None 0.3141 None 0.025 D 0.318 0.501 0.664321979793 gnomAD-4.0.0 1.61529E-06 None None None None I None 0 0 None 0 0 None 0 0 2.89417E-06 0 0
V/I 28786 Ig-144 32 rs1219680583 0.0869 None 0.773 N 0.538 0.301 0.682044198124 gnomAD-4.0.0 2.06612E-06 None None None None I None 0 0 None 0 0 None 0 0 1.80612E-06 0 1.66739E-05
V/A 29076 Ig-145 32 None 0.3603 None 0.999 D 0.676 0.713 0.737052393128 gnomAD-4.0.0 2.05256E-06 None None None None I None 0 0 None 0 0 None 0 5.20472E-04 0 0 0
V/L 29076 Ig-145 32 rs776219010 0.2666 -0.313 0.997 D 0.704 0.473 0.678378258981 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.58E-05 None 0 None 0 0 0
I/T 29472 Ig-146 29 rs1700836863 0.1337 None 0.989 N 0.771 0.693 0.778047502339 gnomAD-4.0.0 1.59134E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85799E-06 0 0
V/A 29871 Ig-147 30 None 0.3528 None 0.999 D 0.631 0.437 None gnomAD-4.0.0 2.40066E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62502E-06 0 0
I/V 30163 Ig-148 32 rs1445875669 0.0721 None 0.046 N 0.234 0.057 0.40722173914 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/V 30957 Ig-150 31 None 0.1578 None 1.0 N 0.681 0.364 0.406120066682 gnomAD-4.0.0 6.84339E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99465E-07 0 0
I/T 32046 Ig-153 30 None 0.6779 None 0.892 D 0.796 0.687 0.804337889494 gnomAD-4.0.0 1.59152E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
I/V 32046 Ig-153 30 None 0.0877 None 0.011 N 0.195 0.087 0.360565625551 gnomAD-4.0.0 1.59151E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85876E-06 0 0
A/G 32338 Ig-154 32 None 0.252 None 0.946 N 0.658 0.322 0.370424759081 gnomAD-4.0.0 2.05258E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79891E-06 0 1.65651E-05
C/Y 32736 Ig-155 29 rs1693533292 0.8711 None 0.999 N 0.863 0.384 0.807158024866 gnomAD-4.0.0 3.18246E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85837E-06 1.43275E-05 0
I/L 33132 Ig-156 32 rs780831102 0.3586 -0.838 0.955 N 0.405 0.469 0.700996906393 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
I/L 33132 Ig-156 32 rs780831102 0.3586 -0.838 0.955 N 0.405 0.469 0.700996906393 gnomAD-4.0.0 5.47402E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19606E-06 0 0
M/I 33228 Ig-157 26 None 0.1331 None None N 0.188 0.122 0.245101548738 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
M/T 33228 Ig-157 26 None 0.4188 None 0.091 N 0.443 0.36 0.788166398384 gnomAD-4.0.0 1.5914E-06 None None None None I None 5.65675E-05 0 None 0 0 None 0 0 0 0 0
M/V 33228 Ig-157 26 None 0.0664 None 0.002 N 0.286 0.187 0.380394304726 gnomAD-4.0.0 1.59144E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8584E-06 0 0
V/I 33527 Ig-158 32 rs2278196 0.0825 -0.388 0.774 N 0.285 0.207 None gnomAD-2.1.1 3.23055E-02 None None None None N None 7.07184E-02 3.01533E-02 None 2.57652E-02 1.54713E-01 None 1.37435E-02 None 3.0024E-03 1.78054E-02 3.04054E-02
V/I 33527 Ig-158 32 rs2278196 0.0825 -0.388 0.774 N 0.285 0.207 None gnomAD-3.1.2 3.7948E-02 None None None None N None 7.01102E-02 3.77606E-02 4.38597E-03 2.8291E-02 1.46059E-01 None 1.88501E-03 5.06329E-02 1.80409E-02 1.2443E-02 5.30593E-02
V/I 33527 Ig-158 32 rs2278196 0.0825 -0.388 0.774 N 0.285 0.207 None 1000 genomes 6.54952E-02 None None None None N None 8.47E-02 3.6E-02 None None 1.488E-01 2.98E-02 None None None 1.12E-02 None
V/I 33527 Ig-158 32 rs2278196 0.0825 -0.388 0.774 N 0.285 0.207 None gnomAD-4.0.0 2.53438E-02 None None None None N None 7.02321E-02 3.31887E-02 None 2.56826E-02 1.61574E-01 None 2.92233E-03 7.9069E-02 1.84834E-02 1.35735E-02 3.07727E-02
I/M 33627 Ig-159 32 rs756942845 0.7635 -0.8 0.999 N 0.696 0.655 0.612784651154 gnomAD-2.1.1 7.14E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.56306E-04 0
I/M 33627 Ig-159 32 rs756942845 0.7635 -0.8 0.999 N 0.696 0.655 0.612784651154 gnomAD-3.1.2 9.21E-05 None None None None N None 0 0 0 0 0 None 0 0 2.05822E-04 0 0
I/M 33627 Ig-159 32 rs756942845 0.7635 -0.8 0.999 N 0.696 0.655 0.612784651154 gnomAD-4.0.0 1.05359E-05 None None None None N None 0 0 None 0 0 None 0 0 1.44099E-05 0 0
V/A 34168 Ig-160 32 rs1022062534 0.7389 None 0.999 D 0.619 0.779 0.802205998338 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
V/A 34168 Ig-160 32 rs1022062534 0.7389 None 0.999 D 0.619 0.779 0.802205998338 gnomAD-4.0.0 3.04488E-06 None None None None N None 5.24219E-05 0 None 0 0 None 0 0 0 0 0
V/A 34289 Ig-161 32 rs1370660271 0.815 -1.753 0.939 D 0.655 0.752 0.792328519658 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
V/A 34289 Ig-161 32 rs1370660271 0.815 -1.753 0.939 D 0.655 0.752 0.792328519658 gnomAD-4.0.0 3.18196E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85768E-06 0 3.02389E-05
V/A 35317 Ig-165 32 rs765504674 0.5085 -1.815 0.003 D 0.412 0.647 0.636883013597 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
V/A 35317 Ig-165 32 rs765504674 0.5085 -1.815 0.003 D 0.412 0.647 0.636883013597 gnomAD-4.0.0 1.59086E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85747E-06 0 0
V/G 35636 Ig-167 30 rs1482221696 0.6188 None 0.997 N 0.866 0.739 0.907856884783 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/G 35636 Ig-167 30 rs1482221696 0.6188 None 0.997 N 0.866 0.739 0.907856884783 gnomAD-4.0.0 6.57289E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47003E-05 0 0
V/M 35636 Ig-167 30 rs751243461 0.4015 -0.374 0.982 N 0.71 0.546 0.614131634805 gnomAD-2.1.1 7.13E-06 None None None None N None 4.13E-05 0 None 0 0 None 3.27E-05 None 0 0 0
V/M 35636 Ig-167 30 rs751243461 0.4015 -0.374 0.982 N 0.71 0.546 0.614131634805 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/M 35636 Ig-167 30 rs751243461 0.4015 -0.374 0.982 N 0.71 0.546 0.614131634805 gnomAD-4.0.0 1.17727E-05 None None None None N None 1.33433E-05 0 None 0 0 None 0 0 1.4408E-05 1.09777E-05 0
I/M 35733 Ig-168 32 rs776237176 0.1443 -0.958 0.994 N 0.701 0.469 0.373537453441 gnomAD-2.1.1 4.07E-06 None None None None I None 6.54E-05 0 None 0 0 None 0 None 0 0 0
I/V 35733 Ig-168 32 None 0.1001 None 0.004 N 0.256 0.138 0.286848849266 gnomAD-4.0.0 2.40064E-06 None None None None I None 1.26695E-04 0 None 0 0 None 0 0 0 0 0
V/A 35928 Ig-169 32 rs763109620 0.5397 -1.97 0.052 D 0.507 0.547 0.658958933578 gnomAD-2.1.1 4.02E-06 None None None -1.643(OBSL1) -0.553(OBSCN) N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
V/A 35928 Ig-169 32 rs763109620 0.5397 -1.97 0.052 D 0.507 0.547 0.658958933578 gnomAD-4.0.0 1.36832E-06 None None None -1.643(OBSL1) -0.553(OBSCN) N None 0 0 None 0 0 None 0 0 1.79881E-06 0 0
V/E 35928 Ig-169 32 rs763109620 0.7945 -1.5 0.484 D 0.737 0.685 0.877444639343 gnomAD-2.1.1 4.02E-06 None None None -1.901(OBSL1) 0.214(OBSCN) N None 0 0 None 0 0 None 0 None 4.65E-05 0 0
V/E 35928 Ig-169 32 rs763109620 0.7945 -1.5 0.484 D 0.737 0.685 0.877444639343 gnomAD-3.1.2 1.31E-05 None None None -1.901(OBSL1) 0.214(OBSCN) N None 0 0 0 0 0 None 1.8843E-04 0 0 0 0
V/E 35928 Ig-169 32 rs763109620 0.7945 -1.5 0.484 D 0.737 0.685 0.877444639343 gnomAD-4.0.0 1.735E-05 None None None -1.901(OBSL1) 0.214(OBSCN) N None 0 0 None 0 0 None 4.06161E-04 0 0 0 3.20215E-05
V/L 35928 Ig-169 32 rs1575170744 0.2867 None 0.002 D 0.399 0.244 0.352048277211 gnomAD-4.0.0 1.36832E-06 None None None -2.081(OBSL1) -0.499(OBSCN) N None 0 0 None 0 0 None 0 0 8.99405E-07 0 1.65645E-05

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.