Structural position:

  • Domain Type: Ig
  • Aligned Position: 51
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
D/E 42 Ig-1 37 None 0.4364 None 0.996 N 0.418 0.476 0.478451964739 gnomAD-4.0.0 1.20032E-06 None None None -0.33(TCAP) N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/G 42 Ig-1 37 rs200838218 0.3474 -0.28 1.0 N 0.694 0.681 0.463758542814 gnomAD-2.1.1 3.98E-06 None None None -0.297(TCAP) N None 6.15E-05 0 None 0 0 None 0 None 0 0 0
D/G 42 Ig-1 37 rs200838218 0.3474 -0.28 1.0 N 0.694 0.681 0.463758542814 gnomAD-4.0.0 2.05223E-06 None None None -0.297(TCAP) N None 5.97372E-05 0 None 0 0 None 0 1.73491E-04 0 0 0
D/N 42 Ig-1 37 rs759317260 0.1841 0.291 1.0 N 0.629 0.429 0.389126455913 gnomAD-2.1.1 3.98E-06 None None None -1.374(TCAP) N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/N 42 Ig-1 37 rs759317260 0.1841 0.291 1.0 N 0.629 0.429 0.389126455913 gnomAD-3.1.2 6.57E-06 None None None -1.374(TCAP) N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/N 42 Ig-1 37 rs759317260 0.1841 0.291 1.0 N 0.629 0.429 0.389126455913 gnomAD-4.0.0 1.85874E-06 None None None -1.374(TCAP) N None 1.33469E-05 0 None 0 0 None 0 0 0 2.19573E-05 0
E/K 979 Ig-3 37 rs778333259 0.9052 -0.167 0.999 N 0.573 0.516 0.530803083455 gnomAD-2.1.1 1.59E-05 None None None None N None 0 0 None 0 0 None 1.30651E-04 None 0 0 0
E/K 979 Ig-3 37 rs778333259 0.9052 -0.167 0.999 N 0.573 0.516 0.530803083455 gnomAD-4.0.0 2.0677E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.86252E-04 0
S/C 1118 Ig-4 37 rs2092847836 0.2121 None 0.928 N 0.386 0.25 0.257786959452 gnomAD-4.0.0 1.36815E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 1.6559E-05
S/Y 1118 Ig-4 37 None 0.2878 None 0.912 N 0.446 0.186 0.37953744168 gnomAD-4.0.0 6.84075E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99305E-07 0 0
D/H 1327 Ig-5 37 None 0.9891 None 1.0 D 0.639 0.391 0.302459207581 gnomAD-4.0.0 1.59125E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85708E-06 0 0
D/N 1327 Ig-5 37 rs1317990922 0.5952 -0.678 0.884 N 0.36 0.261 0.130388298395 gnomAD-2.1.1 4E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/N 1327 Ig-5 37 rs1317990922 0.5952 -0.678 0.884 N 0.36 0.261 0.130388298395 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.3101E-04 0 0 0 None 0 0 0 0 0
D/N 1327 Ig-5 37 rs1317990922 0.5952 -0.678 0.884 N 0.36 0.261 0.130388298395 gnomAD-4.0.0 3.84313E-06 None None None None N None 0 5.08664E-05 None 0 0 None 0 0 0 0 0
D/G 1741 Ig-8 39 rs376751465 0.6881 -0.378 1.0 N 0.637 0.815 None gnomAD-2.1.1 3.99E-06 None None None None N None 6.15E-05 0 None 0 0 None 0 None 0 0 0
D/G 1741 Ig-8 39 rs376751465 0.6881 -0.378 1.0 N 0.637 0.815 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/G 1741 Ig-8 39 rs376751465 0.6881 -0.378 1.0 N 0.637 0.815 None gnomAD-4.0.0 6.56901E-06 None None None None N None 2.41243E-05 0 None 0 0 None 0 0 0 0 0
D/V 1741 Ig-8 39 None 0.9716 None 1.0 D 0.672 0.889 0.841363702225 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
N/I 1877 Ig-9 37 rs1554006798 0.9861 None 1.0 D 0.679 0.517 0.571828761226 gnomAD-4.0.0 6.36207E-06 None None None None N None 0 0 None 0 1.10902E-04 None 0 0 0 0 0
N/S 2114 Ig-10 37 rs372289753 0.3809 0.015 0.999 D 0.575 0.632 None gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.81E-06 0
N/S 2114 Ig-10 37 rs372289753 0.3809 0.015 0.999 D 0.575 0.632 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/S 2114 Ig-10 37 rs372289753 0.3809 0.015 0.999 D 0.575 0.632 None gnomAD-4.0.0 5.1231E-06 None None None None N None 0 0 None 4.08998E-05 0 None 0 0 7.17542E-06 0 0
D/N 2210 Ig-11 37 rs2154345509 0.0526 None 0.001 N 0.068 0.078 0.0482279557977 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/I 2302 Ig-12 36 None 0.4105 None 0.295 D 0.505 0.163 0.461845970543 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/Q 2568 Ig-15 36 rs746270312 0.1044 -0.043 0.997 N 0.583 0.317 0.237489013734 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
K/Q 2568 Ig-15 36 rs746270312 0.1044 -0.043 0.997 N 0.583 0.317 0.237489013734 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
K/Q 2568 Ig-15 36 rs746270312 0.1044 -0.043 0.997 N 0.583 0.317 0.237489013734 gnomAD-4.0.0 3.09829E-06 None None None None N None 0 0 None 0 0 None 0 0 4.23745E-06 0 0
K/R 2568 Ig-15 36 None 0.077 None 0.217 N 0.218 0.132 0.269111216191 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/Y 2655 Ig-16 35 rs1379744895 0.272 -0.214 0.997 D 0.698 0.291 0.423119698836 gnomAD-2.1.1 3.98E-06 None None None None N None 0 2.89E-05 None 0 0 None 0 None 0 0 0
D/Y 2655 Ig-16 35 rs1379744895 0.272 -0.214 0.997 D 0.698 0.291 0.423119698836 gnomAD-4.0.0 1.59064E-06 None None None None N None 0 2.28676E-05 None 0 0 None 0 0 0 0 0
K/N 2830 Ig-18 36 rs768672643 0.2338 0.434 0.884 N 0.307 0.142 0.0954503805726 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
N/S 2917 Ig-19 36 rs1420302039 0.2491 None 0.953 D 0.461 0.603 0.435152311215 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/S 2917 Ig-19 36 rs1420302039 0.2491 None 0.953 D 0.461 0.603 0.435152311215 gnomAD-4.0.0 6.5735E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4702E-05 0 0
D/N 3093 Ig-21 36 rs377376861 0.1387 -0.251 0.007 N 0.212 0.153 None gnomAD-2.1.1 7.96E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.81E-06 0
D/N 3093 Ig-21 36 rs377376861 0.1387 -0.251 0.007 N 0.212 0.153 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
D/N 3093 Ig-21 36 rs377376861 0.1387 -0.251 0.007 N 0.212 0.153 None gnomAD-4.0.0 3.09785E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54234E-06 2.19578E-05 0
D/Y 3093 Ig-21 36 None 0.6986 None 0.642 N 0.651 0.284 0.255270683199 gnomAD-4.0.0 6.84078E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99295E-07 0 0
K/R 3380 Ig-24 36 rs984535715 0.0883 0.314 0.014 N 0.344 0.108 0.288352970974 gnomAD-2.1.1 4E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
K/R 3380 Ig-24 36 rs984535715 0.0883 0.314 0.014 N 0.344 0.108 0.288352970974 gnomAD-4.0.0 9.57781E-06 None None None None N None 0 0 None 0 0 None 0 0 1.25908E-05 0 0
N/K 3501 Ig-25 37 None 0.5391 None None None None 0.211 None gnomAD-4.0.0 6.84197E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15937E-05 0
N/S 3501 Ig-25 37 None 0.1609 None None None None 0.253 None gnomAD-4.0.0 1.20037E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31256E-06 0 0
E/K 3696 Ig-26 37 rs184205694 0.1194 0.556 None None None 0.036 None gnomAD-2.1.1 1.21E-05 None None None None I None 1.29166E-04 0 None 0 0 None 0 None 0 8.88E-06 0
E/K 3696 Ig-26 37 rs184205694 0.1194 0.556 None None None 0.036 None gnomAD-3.1.2 3.29E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 4.41E-05 0 0
E/K 3696 Ig-26 37 rs184205694 0.1194 0.556 None None None 0.036 None 1000 genomes 3.99361E-04 None None None None I None 1.5E-03 0 None None 0 0 None None None 0 None
E/K 3696 Ig-26 37 rs184205694 0.1194 0.556 None None None 0.036 None gnomAD-4.0.0 1.17735E-05 None None None None I None 5.33163E-05 1.66678E-05 None 0 0 None 0 0 1.10187E-05 0 1.60051E-05
N/S 3856 Ig-27 37 rs765523683 0.1038 -0.516 0.124 N 0.499 0.221 None gnomAD-2.1.1 1.43E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.34E-05 1.40292E-04
N/S 3856 Ig-27 37 rs765523683 0.1038 -0.516 0.124 N 0.499 0.221 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
N/S 3856 Ig-27 37 rs765523683 0.1038 -0.516 0.124 N 0.499 0.221 None gnomAD-4.0.0 1.30133E-05 None None None None I None 0 0 None 0 0 None 0 0 1.6952E-05 0 1.60102E-05
E/G 4640 Ig-29 35 rs1441462753 0.0856 -0.969 None N 0.169 0.071 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
E/G 4640 Ig-29 35 rs1441462753 0.0856 -0.969 None N 0.169 0.071 None gnomAD-4.0.0 4.10582E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49766E-06 0 1.65684E-05
E/K 4640 Ig-29 35 rs1156910102 0.0942 None None N 0.134 0.065 None gnomAD-4.0.0 1.5917E-06 None None None None N None 5.65291E-05 0 None 0 0 None 0 0 0 0 0
E/Q 4640 Ig-29 35 rs1156910102 0.0924 -0.441 0.003 N 0.171 0.064 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/Q 4640 Ig-29 35 rs1156910102 0.0924 -0.441 0.003 N 0.171 0.064 None gnomAD-4.0.0 1.5917E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43303E-05 0
D/G 4831 Ig-31 37 rs1257773327 0.2041 -0.528 1.0 N 0.667 0.592 0.17258766438 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
D/G 4831 Ig-31 37 rs1257773327 0.2041 -0.528 1.0 N 0.667 0.592 0.17258766438 gnomAD-4.0.0 1.5912E-06 None None None None N None 0 0 None 0 2.77393E-05 None 0 0 0 0 0
D/N 4831 Ig-31 37 None 0.1187 None 1.0 N 0.615 0.311 0.143124449307 gnomAD-4.0.0 1.59123E-06 None None None None N None 0 0 None 0 0 None 1.88274E-05 0 0 0 0
D/Y 4831 Ig-31 37 rs768490595 0.3427 -0.026 1.0 D 0.639 0.492 0.633345530651 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 8.87E-06 0
D/Y 4831 Ig-31 37 rs768490595 0.3427 -0.026 1.0 D 0.639 0.492 0.633345530651 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/Y 4831 Ig-31 37 rs768490595 0.3427 -0.026 1.0 D 0.639 0.492 0.633345530651 gnomAD-4.0.0 1.40915E-05 None None None None N None 0 0 None 0 0 None 1.25518E-04 0 4.78574E-06 0 2.84414E-05
D/G 4924 Ig-32 37 rs1560852223 0.1027 None 0.201 N 0.584 0.272 0.152612264143 gnomAD-4.0.0 1.36844E-06 None None None None N None 0 0 None 0 0 None 0 1.73551E-04 8.99442E-07 0 0
D/N 4924 Ig-32 37 rs1330716005 0.0693 None 0.004 N 0.352 0.077 0.130388298395 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 4924 Ig-32 37 rs1330716005 0.0693 None 0.004 N 0.352 0.077 0.130388298395 gnomAD-4.0.0 6.57117E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47003E-05 0 0
D/V 4924 Ig-32 37 rs1560852223 0.2242 None 0.781 N 0.652 0.383 0.548022476061 gnomAD-4.0.0 3.4211E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49721E-06 0 0
N/S 5018 Ig-33 38 None 0.215 None 0.201 D 0.437 0.262 0.149567049428 gnomAD-4.0.0 3.60097E-06 None None None None N None 1.90042E-04 0 None 0 0 None 0 0 0 0 0
D/E 5111 Ig-34 37 None 0.3171 None 0.026 D 0.22 0.273 0.158396225186 gnomAD-4.0.0 6.84257E-07 None None None None N None 2.98757E-05 0 None 0 0 None 0 0 0 0 0
D/G 5111 Ig-34 37 None 0.2203 None 0.896 D 0.488 0.669 0.412587454835 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/D 5204 Ig-35 37 rs1171039782 0.1047 -0.382 0.001 N 0.308 0.258 0.0846915920261 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/Y 5297 Ig-36 37 rs2080895374 0.305 None 0.999 D 0.614 0.417 0.689665905704 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92901E-04 None 0 0 0 0 0
D/Y 5297 Ig-36 37 rs2080895374 0.305 None 0.999 D 0.614 0.417 0.689665905704 gnomAD-4.0.0 2.56232E-06 None None None None I None 0 0 None 0 2.42483E-05 None 0 0 0 0 2.84446E-05
D/E 5393 Ig-37 37 rs768837104 0.2018 -0.22 0.006 N 0.195 0.093 0.0954503805726 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
D/E 5393 Ig-37 37 rs768837104 0.2018 -0.22 0.006 N 0.195 0.093 0.0954503805726 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/E 5393 Ig-37 37 rs768837104 0.2018 -0.22 0.006 N 0.195 0.093 0.0954503805726 gnomAD-4.0.0 7.4378E-06 None None None None N None 1.33551E-05 0 None 0 0 None 0 0 9.3241E-06 0 0
D/H 5393 Ig-37 37 None 0.3206 None 0.008 N 0.351 0.291 0.215869574891 gnomAD-4.0.0 6.84316E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99502E-07 0 0
D/N 5393 Ig-37 37 rs867980863 0.0827 -0.224 0.001 N 0.166 0.118 0.154104182512 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 1.12145E-04 None 0 None 0 0 0
D/N 5393 Ig-37 37 rs867980863 0.0827 -0.224 0.001 N 0.166 0.118 0.154104182512 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 3.86997E-04 None 0 0 0 0 0
D/N 5393 Ig-37 37 rs867980863 0.0827 -0.224 0.001 N 0.166 0.118 0.154104182512 gnomAD-4.0.0 1.92135E-05 None None None None N None 0 0 None 0 6.92676E-04 None 0 0 0 0 0
D/Y 5393 Ig-37 37 None 0.2154 None 0.627 N 0.495 0.344 0.29527378943 gnomAD-4.0.0 6.84316E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99502E-07 0 0
G/D 5486 Ig-38 37 None 0.0851 None 0.003 N 0.32 0.128 0.0920862733494 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
G/S 5486 Ig-38 37 rs1430669284 0.1364 -0.391 0.338 N 0.492 0.298 0.159798565429 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
G/S 5486 Ig-38 37 rs1430669284 0.1364 -0.391 0.338 N 0.492 0.298 0.159798565429 gnomAD-4.0.0 1.36856E-06 None None None None N None 0 2.23754E-05 None 0 0 None 0 0 8.99509E-07 0 0
N/D 5580 Ig-39 38 rs376598696 0.0945 None 0.02 N 0.235 0.087 None gnomAD-2.1.1 2.14E-05 None None None None N None 2.48036E-04 0 None 0 0 None 0 None 0 0 0
N/D 5580 Ig-39 38 rs376598696 0.0945 None 0.02 N 0.235 0.087 None gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
N/D 5580 Ig-39 38 rs376598696 0.0945 None 0.02 N 0.235 0.087 None gnomAD-4.0.0 8.96753E-06 None None None None N None 1.18399E-04 0 None 0 0 None 0 0 0 0 0
D/G 5673 Ig-40 37 rs774163706 0.1685 0.16 0.989 N 0.548 0.361 0.188950314367 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
D/G 5673 Ig-40 37 rs774163706 0.1685 0.16 0.989 N 0.548 0.361 0.188950314367 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
D/G 5673 Ig-40 37 rs774163706 0.1685 0.16 0.989 N 0.548 0.361 0.188950314367 gnomAD-4.0.0 4.95754E-06 None None None None N None 1.3349E-05 0 None 0 0 None 0 0 2.54289E-06 3.29366E-05 1.60118E-05
D/V 5673 Ig-40 37 rs774163706 0.7275 0.367 0.998 N 0.663 0.447 0.537448724652 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
D/V 5673 Ig-40 37 rs774163706 0.7275 0.367 0.998 N 0.663 0.447 0.537448724652 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/V 5673 Ig-40 37 rs774163706 0.7275 0.367 0.998 N 0.663 0.447 0.537448724652 gnomAD-4.0.0 1.67317E-05 None None None None N None 0 0 None 0 0 None 0 0 2.2886E-05 0 0
D/E 5766 Ig-41 37 None 0.2858 None 1.0 N 0.423 0.268 0.201204373187 gnomAD-4.0.0 6.84237E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99467E-07 0 0
D/G 5766 Ig-41 37 rs1477878584 0.1781 -0.474 1.0 N 0.687 0.511 0.208000267992 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/G 5766 Ig-41 37 rs1477878584 0.1781 -0.474 1.0 N 0.687 0.511 0.208000267992 gnomAD-4.0.0 1.59145E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
D/N 5766 Ig-41 37 None 0.1588 None 1.0 N 0.633 0.318 0.199424873507 gnomAD-4.0.0 1.59148E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8583E-06 0 0
D/G 5955 Ig-43 37 None 0.168 None 0.978 N 0.533 0.372 0.200317383148 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
D/G 6048 Ig-44 37 rs1400771825 0.1445 -0.329 0.989 N 0.479 0.453 0.275641507738 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.62E-05 None 0 None 0 0 0
D/G 6048 Ig-44 37 rs1400771825 0.1445 -0.329 0.989 N 0.479 0.453 0.275641507738 gnomAD-4.0.0 3.18501E-06 None None None None N None 0 0 None 0 5.56143E-05 None 0 0 0 0 0
D/E 6142 Ig-45 38 None 0.2244 None 0.893 N 0.274 0.349 0.221019684889 gnomAD-4.0.0 3.42126E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49749E-06 0 0
D/G 6142 Ig-45 38 None 0.1315 None 0.998 N 0.642 0.569 0.469989170139 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/K 6235 Ig-46 37 rs766055257 0.5272 0.35 0.92 N 0.331 0.229 0.134241683229 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
N/K 6235 Ig-46 37 rs766055257 0.5272 0.35 0.92 N 0.331 0.229 0.134241683229 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/K 6235 Ig-46 37 rs766055257 0.5272 0.35 0.92 N 0.331 0.229 0.134241683229 gnomAD-4.0.0 3.71877E-06 None None None None N None 0 0 None 0 0 None 0 0 4.23866E-06 0 1.60133E-05
N/S 6235 Ig-46 37 rs2079993234 0.1409 None 0.704 N 0.381 0.224 0.158396225186 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/S 6235 Ig-46 37 rs2079993234 0.1409 None 0.704 N 0.381 0.224 0.158396225186 gnomAD-4.0.0 2.56265E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78758E-06 0 0
N/Y 6235 Ig-46 37 None 0.2743 None 0.996 N 0.442 0.41 0.517655672 gnomAD-4.0.0 2.05287E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.47802E-05 0
D/G 6517 Ig-49 37 rs904836264 0.2436 None 0.434 N 0.373 0.333 0.18274738541 gnomAD-4.0.0 1.36884E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99653E-07 0 1.65755E-05
D/E 6610 Ig-50 37 None 0.165 None 0.002 N 0.142 0.108 0.134241683229 gnomAD-4.0.0 1.59229E-06 None None None None N None 0 0 None 0 2.77377E-05 None 0 0 0 0 0
D/G 6610 Ig-50 37 None 0.1067 None 0.918 N 0.536 0.327 0.185906805712 gnomAD-4.0.0 6.84404E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99716E-07 0 0
D/H 6610 Ig-50 37 None 0.3915 None 0.131 N 0.342 0.454 0.20549828249 gnomAD-4.0.0 3.18461E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86681E-05 0
D/V 6610 Ig-50 37 rs755182614 0.3899 0.157 0.986 N 0.617 0.521 0.567605623258 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/V 6610 Ig-50 37 rs755182614 0.3899 0.157 0.986 N 0.617 0.521 0.567605623258 gnomAD-4.0.0 6.84404E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15977E-05 0
D/E 6797 Ig-52 37 rs755018617 0.3904 -0.049 0.026 D 0.251 0.247 0.104622674875 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/E 6797 Ig-52 37 rs755018617 0.3904 -0.049 0.026 D 0.251 0.247 0.104622674875 gnomAD-4.0.0 3.18613E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72243E-06 0 0
E/K 6890 Ig-53 37 None 0.3251 None 0.324 N 0.445 0.235 0.231231049324 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 6984 Ig-54 37 None 0.11 None 0.801 N 0.421 0.255 0.136095386433 gnomAD-4.0.0 1.59206E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43295E-05 0
G/D 7173 Ig-56 37 rs1479016308 0.198 None 0.121 N 0.28 0.182 0.148003135375 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/D 7173 Ig-56 37 rs1479016308 0.198 None 0.121 N 0.28 0.182 0.148003135375 gnomAD-4.0.0 3.04503E-06 None None None None N None 0 0 None 0 1.13533E-04 None 0 0 2.40989E-06 0 0
G/S 7173 Ig-56 37 rs1451038846 0.1541 -0.535 0.978 N 0.45 0.321 0.243398259712 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
G/S 7173 Ig-56 37 rs1451038846 0.1541 -0.535 0.978 N 0.45 0.321 0.243398259712 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
G/S 7173 Ig-56 37 rs1451038846 0.1541 -0.535 0.978 N 0.45 0.321 0.243398259712 gnomAD-4.0.0 7.43853E-06 None None None None N None 0 0 None 0 0 None 0 0 1.01731E-05 0 0
D/E 7455 Ig-59 37 rs756430663 0.3834 -0.373 0.907 D 0.42 0.45 0.251639045875 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
D/E 7455 Ig-59 37 rs756430663 0.3834 -0.373 0.907 D 0.42 0.45 0.251639045875 gnomAD-4.0.0 1.36869E-06 None None None None N None 0 0 None 0 0 None 0 1.73491E-04 0 0 1.65706E-05
D/E 7551 Ig-60 37 rs371736246 0.3186 -0.329 0.002 N 0.208 0.072 0.171388866994 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 2.66E-05 0
D/E 7551 Ig-60 37 rs371736246 0.3186 -0.329 0.002 N 0.208 0.072 0.171388866994 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/E 7551 Ig-60 37 rs371736246 0.3186 -0.329 0.002 N 0.208 0.072 0.171388866994 gnomAD-4.0.0 9.91682E-06 None None None None N None 0 0 None 0 0 None 0 0 1.18686E-05 2.19679E-05 0
D/V 7551 Ig-60 37 None 0.7593 None 0.962 N 0.711 0.405 0.493695379898 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
D/Y 7551 Ig-60 37 None 0.5571 None 0.999 N 0.691 0.434 0.57674044448 gnomAD-4.0.0 1.59202E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85987E-06 0 0
D/H 7831 Ig-63 37 rs1220028372 0.6617 0.112 0.652 N 0.525 0.36 0.226586394389 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/H 7831 Ig-63 37 rs1220028372 0.6617 0.112 0.652 N 0.525 0.36 0.226586394389 gnomAD-4.0.0 3.42122E-06 None None None None N None 0 0 None 0 0 None 0 1.7343E-04 3.59804E-06 0 0
G/D 8114 Ig-66 37 rs923868923 0.1718 None 0.275 N 0.423 0.247 0.104622674875 gnomAD-4.0.0 1.59143E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.0248E-05
D/E 8207 Ig-67 37 rs751733811 0.2027 -0.239 0.002 N 0.115 0.189 0.0806252709748 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 9.81E-05 None 0 0 0
D/E 8207 Ig-67 37 rs751733811 0.2027 -0.239 0.002 N 0.115 0.189 0.0806252709748 gnomAD-4.0.0 2.73696E-06 None None None None I None 0 0 None 0 0 None 0 0 0 4.63736E-05 0
D/N 8207 Ig-67 37 rs756813056 0.0637 -0.557 None N 0.091 0.111 0.0920862733494 gnomAD-2.1.1 3.22E-05 None None None None I None 0 1.74014E-04 None 0 0 None 0 None 0 0 3.31565E-04
D/N 8207 Ig-67 37 rs756813056 0.0637 -0.557 None N 0.091 0.111 0.0920862733494 gnomAD-3.1.2 5.26E-05 None None None None I None 0 5.23629E-04 0 0 0 None 0 0 0 0 0
D/N 8207 Ig-67 37 rs756813056 0.0637 -0.557 None N 0.091 0.111 0.0920862733494 gnomAD-4.0.0 1.30143E-05 None None None None I None 0 2.6672E-04 None 0 0 None 0 0 1.69527E-06 0 4.80384E-05
D/Y 8207 Ig-67 37 None 0.2708 None 0.741 N 0.445 0.268 0.339074221408 gnomAD-4.0.0 1.36849E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79899E-06 0 0
E/D 8300 Ig-68 37 rs1438429191 0.1 0.092 None N 0.123 0.14 0.0297737177859 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/D 8300 Ig-68 37 rs1438429191 0.1 0.092 None N 0.123 0.14 0.0297737177859 gnomAD-4.0.0 6.8472E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15942E-05 0
E/K 8300 Ig-68 37 rs1300968279 0.2401 None 0.236 N 0.285 0.359 0.32980341726 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
E/K 8300 Ig-68 37 rs1300968279 0.2401 None 0.236 N 0.285 0.359 0.32980341726 gnomAD-4.0.0 6.57583E-06 None None None None N None 2.41546E-05 0 None 0 0 None 0 0 0 0 0
E/Q 8300 Ig-68 37 rs1300968279 0.1641 0.28 0.52 N 0.315 0.318 0.257292322809 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/Q 8300 Ig-68 37 rs1300968279 0.1641 0.28 0.52 N 0.315 0.318 0.257292322809 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/Q 8300 Ig-68 37 rs1300968279 0.1641 0.28 0.52 N 0.315 0.318 0.257292322809 gnomAD-4.0.0 5.13343E-06 None None None None N None 0 6.77897E-05 None 0 0 None 0 0 0 0 0
D/N 8396 Ig-69 37 rs771290213 0.1575 -0.271 0.545 N 0.335 0.21 0.0666544352282 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 9.97E-05 0 None 0 None 0 0 0
D/N 8396 Ig-69 37 rs771290213 0.1575 -0.271 0.545 N 0.335 0.21 0.0666544352282 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 8396 Ig-69 37 rs771290213 0.1575 -0.271 0.545 N 0.335 0.21 0.0666544352282 gnomAD-4.0.0 2.56338E-06 None None None None N None 0 0 None 4.09098E-05 0 None 0 0 2.39403E-06 0 0
D/A 8492 Ig-70 37 None 0.6019 None 0.997 N 0.642 0.453 0.341226946553 gnomAD-4.0.0 6.84268E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99541E-07 0 0
D/E 8492 Ig-70 37 rs777349143 0.3185 -0.113 0.12 N 0.338 0.098 0.0611884634855 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
D/E 8492 Ig-70 37 rs777349143 0.3185 -0.113 0.12 N 0.338 0.098 0.0611884634855 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 2.06868E-04 0
D/E 8492 Ig-70 37 rs777349143 0.3185 -0.113 0.12 N 0.338 0.098 0.0611884634855 gnomAD-4.0.0 5.57758E-06 None None None None N None 1.33494E-05 0 None 0 0 None 0 1.64474E-04 4.23838E-06 2.19578E-05 0
D/G 8492 Ig-70 37 None 0.3345 None 0.993 N 0.673 0.457 0.267755039894 gnomAD-4.0.0 6.84268E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99541E-07 0 0
D/N 8492 Ig-70 37 rs770655555 0.2325 0.39 0.997 N 0.651 0.272 0.284150004643 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
D/N 8492 Ig-70 37 rs770655555 0.2325 0.39 0.997 N 0.651 0.272 0.284150004643 gnomAD-4.0.0 1.36854E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99543E-07 0 1.65689E-05
D/Y 8492 Ig-70 37 rs770655555 0.6597 None 1.0 N 0.7 0.412 0.508223314113 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/Y 8492 Ig-70 37 rs770655555 0.6597 None 1.0 N 0.7 0.412 0.508223314113 gnomAD-4.0.0 6.57073E-06 None None None None N None 2.41173E-05 0 None 0 0 None 0 0 0 0 0
D/N 8586 Ig-71 38 rs1199035064 0.0704 -0.546 None N 0.091 0.086 0.12205267543 gnomAD-2.1.1 4.03E-06 None None None None N None 6.48E-05 0 None 0 0 None 0 None 0 0 0
D/N 8586 Ig-71 38 rs1199035064 0.0704 -0.546 None N 0.091 0.086 0.12205267543 gnomAD-4.0.0 3.42209E-06 None None None None N None 1.19581E-04 0 None 0 0 None 0 0 0 0 1.65711E-05
D/V 8586 Ig-71 38 rs1484446680 0.394 -0.067 0.013 N 0.479 0.215 0.322230723748 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
D/V 8586 Ig-71 38 rs1484446680 0.394 -0.067 0.013 N 0.479 0.215 0.322230723748 gnomAD-4.0.0 1.5924E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43386E-05 0
D/A 8679 Ig-72 37 rs373587266 0.461 None 0.999 N 0.59 0.453 0.37262878642 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/A 8679 Ig-72 37 rs373587266 0.461 None 0.999 N 0.59 0.453 0.37262878642 gnomAD-4.0.0 6.56564E-06 None None None None N None 2.40535E-05 0 None 0 0 None 0 0 0 0 0
D/V 8679 Ig-72 37 None 0.6381 None 1.0 N 0.697 0.468 0.549460442827 gnomAD-4.0.0 1.5914E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85876E-06 0 0
D/V 8772 Ig-73 37 None 0.3891 None 0.682 N 0.713 0.404 0.42828666871 gnomAD-4.0.0 1.20033E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
D/Y 8772 Ig-73 37 None 0.3507 None 0.997 N 0.707 0.447 0.617940983249 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
D/E 8866 Ig-74 37 None 0.2304 None 0.024 N 0.273 0.12 0.199424873507 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
D/G 8866 Ig-74 37 rs2077094217 0.1187 None 0.477 N 0.519 0.26 0.18274738541 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92827E-04 None 0 0 0 0 0
D/G 8866 Ig-74 37 rs2077094217 0.1187 None 0.477 N 0.519 0.26 0.18274738541 gnomAD-4.0.0 6.5672E-06 None None None None N None 0 0 None 0 1.93274E-04 None 0 0 0 0 0
D/N 8866 Ig-74 37 rs2077094495 0.0791 None 0.006 N 0.248 0.115 0.144782658237 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
E/D 8962 Ig-75 37 rs2076925397 0.0959 None None N 0.101 0.117 0.0611884634855 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/D 8962 Ig-75 37 rs2076925397 0.0959 None None N 0.101 0.117 0.0611884634855 gnomAD-4.0.0 6.57263E-06 None None None None N None 0 6.55136E-05 None 0 0 None 0 0 0 0 0
E/V 8962 Ig-75 37 None 0.2769 None 0.055 N 0.425 0.098 0.316788114976 gnomAD-4.0.0 3.18641E-06 None None None None N None 0 0 None 0 0 None 0 2.4108E-04 2.86113E-06 0 0
G/D 9055 Ig-76 37 rs1297995123 0.1533 None 0.011 N 0.261 0.171 0.0920862733494 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/D 9055 Ig-76 37 rs1297995123 0.1533 None 0.011 N 0.261 0.171 0.0920862733494 gnomAD-4.0.0 6.57168E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
G/R 9055 Ig-76 37 rs776617677 0.536 0.004 0.968 N 0.589 0.328 0.464442853059 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
G/V 9055 Ig-76 37 None 0.4062 None 0.984 N 0.64 0.241 0.535152128566 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/E 9241 Ig-78 37 rs2154295843 0.2615 None 0.994 N 0.539 0.288 0.298403945805 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.92976E-04 None 0 0 0 0 0
G/E 9241 Ig-78 37 rs2154295843 0.2615 None 0.994 N 0.539 0.288 0.298403945805 gnomAD-4.0.0 6.57056E-06 None None None None N None 0 0 None 0 1.93424E-04 None 0 0 0 0 0
G/V 9241 Ig-78 37 None 0.5348 None 0.994 N 0.64 0.268 0.512192450023 gnomAD-4.0.0 1.59129E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
D/E 9337 Ig-79 37 rs757848062 0.4644 -0.134 0.998 None 0.434 0.354 0.0297737177859 gnomAD-2.1.1 4.01E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/E 9337 Ig-79 37 rs757848062 0.4644 -0.134 0.998 None 0.434 0.354 0.0297737177859 gnomAD-4.0.0 6.84175E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65645E-05
D/E 9433 Ig-80 37 rs372608982 0.4045 -0.401 0.977 None 0.439 0.206 0.226586394389 gnomAD-2.1.1 4.82E-05 None None None None N None 0 5.8E-05 None 0 0 None 9.8E-05 None 0 1.77E-05 8.26446E-04
D/E 9433 Ig-80 37 rs372608982 0.4045 -0.401 0.977 None 0.439 0.206 0.226586394389 gnomAD-3.1.2 3.94E-05 None None None None N None 0 2.62089E-04 0 0 0 None 0 0 1.47E-05 0 4.78469E-04
D/E 9433 Ig-80 37 rs372608982 0.4045 -0.401 0.977 None 0.439 0.206 0.226586394389 gnomAD-4.0.0 2.29276E-05 None None None None N None 0 8.33639E-05 None 0 0 None 0 8.21828E-04 1.52563E-05 6.58704E-05 4.80277E-05
D/G 9433 Ig-80 37 rs1441669143 0.2935 None 0.955 None 0.634 0.394 0.26169431596 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/G 9433 Ig-80 37 rs1441669143 0.2935 None 0.955 None 0.634 0.394 0.26169431596 gnomAD-4.0.0 6.57091E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47007E-05 0 0
D/H 9433 Ig-80 37 rs781329594 0.753 -0.634 0.999 None 0.705 0.428 0.363944505237 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/H 9433 Ig-80 37 rs781329594 0.753 -0.634 0.999 None 0.705 0.428 0.363944505237 gnomAD-4.0.0 1.59099E-06 None None None None N None 0 2.28676E-05 None 0 0 None 0 0 0 0 0
A/D 9626 Ig-82 37 rs397517530 0.3343 -0.295 0.001 None 0.231 0.204 None gnomAD-2.1.1 1.78E-05 None None None None N None 0 1.13231E-04 None 0 0 None 0 None 0 7.79E-06 0
A/D 9626 Ig-82 37 rs397517530 0.3343 -0.295 0.001 None 0.231 0.204 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
A/D 9626 Ig-82 37 rs397517530 0.3343 -0.295 0.001 None 0.231 0.204 None gnomAD-4.0.0 4.33751E-05 None None None None N None 1.33465E-05 1.33373E-04 None 0 0 None 0 0 5.08533E-05 0 1.60087E-05
A/V 9626 Ig-82 37 None 0.2907 None 0.492 None 0.415 0.151 0.204665344411 gnomAD-4.0.0 6.84169E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99421E-07 0 0
G/R 9734 Ig-83 37 None 0.9955 None 1.0 None 0.591 0.452 0.416956310301 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/R 9937 Ig-84 38 rs2075573477 0.979 None 1.0 None 0.605 0.442 0.450152462452 gnomAD-4.0.0 1.59557E-06 None None None None N None 5.65483E-05 0 None 0 0 None 0 0 0 0 0
D/G 13815 Ig-88 36 rs771949273 0.5428 -0.286 0.955 N 0.499 0.351 0.168933306366 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 0 0
D/G 13815 Ig-88 36 rs771949273 0.5428 -0.286 0.955 N 0.499 0.351 0.168933306366 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07383E-04 0
D/G 13815 Ig-88 36 rs771949273 0.5428 -0.286 0.955 N 0.499 0.351 0.168933306366 gnomAD-4.0.0 7.43927E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.31793E-04 0
G/V 13909 Ig-89 34 None 0.8008 None 0.981 D 0.837 0.304 0.499535901811 gnomAD-4.0.0 6.93745E-07 None None None None N None 0 0 None 0 0 None 0 0 9.08473E-07 0 0
G/A 14088 Ig-91 35 None 0.3959 None 1.0 N 0.536 0.389 0.202086224978 gnomAD-4.0.0 6.8438E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99645E-07 0 0
G/E 14088 Ig-91 35 rs2060182595 0.4489 None 1.0 N 0.7 0.393 0.368743488249 gnomAD-4.0.0 6.8438E-07 None None None None N None 0 0 None 0 2.52207E-05 None 0 0 0 0 0
D/G 14265 Ig-93 35 rs1009314740 0.1369 -0.612 0.955 N 0.515 0.385 0.286081765059 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
D/G 14265 Ig-93 35 rs1009314740 0.1369 -0.612 0.955 N 0.515 0.385 0.286081765059 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
D/G 14265 Ig-93 35 rs1009314740 0.1369 -0.612 0.955 N 0.515 0.385 0.286081765059 gnomAD-4.0.0 3.0992E-06 None None None None N None 5.34045E-05 0 None 0 0 None 0 0 0 0 1.60179E-05
D/N 14265 Ig-93 35 rs758416170 0.0879 -0.3 0.117 N 0.288 0.15 0.228597637076 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
D/Y 14265 Ig-93 35 rs758416170 0.2979 -0.004 1.0 D 0.662 0.429 0.537356456974 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.61E-05 None 0 None 0 0 0
D/Y 14265 Ig-93 35 rs758416170 0.2979 -0.004 1.0 D 0.662 0.429 0.537356456974 gnomAD-4.0.0 1.5922E-06 None None None None N None 0 0 None 0 2.78133E-05 None 0 0 0 0 0
G/R 14443 Ig-95 36 rs1470566986 0.8174 -0.586 1.0 D 0.577 0.532 0.647582611936 gnomAD-2.1.1 8.08E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
G/R 14443 Ig-95 36 rs1470566986 0.8174 -0.586 1.0 D 0.577 0.532 0.647582611936 gnomAD-4.0.0 3.18398E-06 None None None None N None 0 4.57373E-05 None 0 0 None 0 0 0 0 0
N/H 14532 Ig-96 36 None 0.5112 None 1.0 D 0.529 0.743 0.599259136914 gnomAD-4.0.0 3.20359E-06 None None None None N None 0 0 None 0 0 None 0 0 5.74713E-06 0 0
D/N 14621 Ig-97 36 rs374032491 0.1591 0.508 1.0 N 0.637 0.357 None gnomAD-2.1.1 7.66E-05 None None None None N None 0 0 None 1.39331E-03 0 None 0 None 0 3.56E-05 1.66556E-04
D/N 14621 Ig-97 36 rs374032491 0.1591 0.508 1.0 N 0.637 0.357 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 2.88351E-04 0 None 0 0 0 0 0
D/N 14621 Ig-97 36 rs374032491 0.1591 0.508 1.0 N 0.637 0.357 None gnomAD-4.0.0 2.97557E-05 None None None None N None 0 0 None 1.3519E-03 0 None 0 0 1.6955E-06 0 9.61415E-05
K/N 14710 Ig-98 36 None 0.4825 None 0.999 N 0.637 0.171 0.128392430309 gnomAD-4.0.0 6.84456E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99747E-07 0 0
K/Q 14710 Ig-98 36 None 0.2091 None 0.997 N 0.639 0.284 0.223146558224 gnomAD-4.0.0 2.05388E-06 None None None None N None 0 2.23694E-05 None 0 0 None 0 0 1.80003E-06 0 0
D/N 14977 Ig-101 36 rs778989426 0.1615 0.318 0.996 N 0.595 0.341 0.322230723748 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
D/N 14977 Ig-101 36 rs778989426 0.1615 0.318 0.996 N 0.595 0.341 0.322230723748 gnomAD-4.0.0 6.58345E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07039E-04 0
D/V 14977 Ig-101 36 rs1343831802 0.6812 0.228 0.085 D 0.483 0.432 0.416328079214 gnomAD-2.1.1 4.13E-06 None None None None N None 0 0 None 0 5.78E-05 None 0 None 0 0 0
G/E 15066 Ig-102 36 rs746860214 0.2491 -0.747 1.0 D 0.66 0.455 None gnomAD-2.1.1 8.08E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 8.96E-06 0
G/E 15066 Ig-102 36 rs746860214 0.2491 -0.747 1.0 D 0.66 0.455 None gnomAD-3.1.2 1.98E-05 None None None None N None 7.25E-05 0 0 0 0 None 0 0 0 0 0
G/E 15066 Ig-102 36 rs746860214 0.2491 -0.747 1.0 D 0.66 0.455 None gnomAD-4.0.0 1.97623E-05 None None None None N None 7.25163E-05 0 None 0 0 None 0 0 0 0 0
G/R 15066 Ig-102 36 rs768414586 0.4719 -0.521 1.0 D 0.637 0.496 0.85265843411 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
G/R 15066 Ig-102 36 rs768414586 0.4719 -0.521 1.0 D 0.637 0.496 0.85265843411 gnomAD-4.0.0 1.36935E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79982E-06 0 0
D/E 15155 Ig-103 36 rs1264511051 0.2538 None 0.801 N 0.389 0.093 0.163833314356 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
D/E 15155 Ig-103 36 rs1264511051 0.2538 None 0.801 N 0.389 0.093 0.163833314356 gnomAD-4.0.0 1.31692E-05 None None None None N None 4.83068E-05 0 None 0 0 None 0 0 0 0 0
D/G 15155 Ig-103 36 None 0.1522 None 0.002 N 0.161 0.211 0.0920862733494 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
D/N 15155 Ig-103 36 None 0.1368 None 0.012 N 0.191 0.226 0.128392430309 gnomAD-4.0.0 6.84766E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15993E-05 0
N/H 15337 Ig-105 36 None 0.2614 None 0.996 D 0.41 0.322 0.238096912614 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/I 15337 Ig-105 36 rs762315032 0.6909 0.101 0.988 D 0.462 0.34 0.528461186488 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
N/I 15337 Ig-105 36 rs762315032 0.6909 0.101 0.988 D 0.462 0.34 0.528461186488 gnomAD-4.0.0 1.71198E-05 None None None None N None 2.99473E-05 0 None 0 0 None 0 0 2.16011E-05 0 0
N/Y 15426 Ig-106 36 rs763751237 0.464 -0.604 0.963 D 0.468 0.61 0.709004203348 gnomAD-2.1.1 1.06E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.19E-05 0
N/Y 15426 Ig-106 36 rs763751237 0.464 -0.604 0.963 D 0.468 0.61 0.709004203348 gnomAD-4.0.0 5.76349E-06 None None None None N None 0 0 None 0 0 None 0 0 7.40997E-06 0 0
E/K 15604 Ig-108 37 rs749463044 0.1974 0.552 0.024 N 0.264 0.144 0.18995819373 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/K 15604 Ig-108 37 rs749463044 0.1974 0.552 0.024 N 0.264 0.144 0.18995819373 gnomAD-4.0.0 1.36996E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.32051E-05 0
A/S 16295 Ig-110 34 rs757122712 0.0972 -0.145 0.996 N 0.549 0.224 0.289474373501 gnomAD-2.1.1 7.17E-06 None None None None N None 8.28E-05 0 None 0 0 None 0 None 0 0 0
A/S 16295 Ig-110 34 rs757122712 0.0972 -0.145 0.996 N 0.549 0.224 0.289474373501 gnomAD-3.1.2 1.98E-05 None None None None N None 7.25E-05 0 0 0 0 None 0 0 0 0 0
A/S 16295 Ig-110 34 rs757122712 0.0972 -0.145 0.996 N 0.549 0.224 0.289474373501 gnomAD-4.0.0 5.13363E-06 None None None None N None 6.78173E-05 0 None 0 0 None 0 0 0 0 0
A/V 16295 Ig-110 34 None 0.45 None 0.999 N 0.647 0.257 0.352910780287 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/E 16991 Ig-111 37 rs968016218 0.2653 None 0.977 N 0.387 0.252 0.223847106136 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/E 16991 Ig-111 37 rs968016218 0.2653 None 0.977 N 0.387 0.252 0.223847106136 gnomAD-4.0.0 7.441E-06 None None None None N None 0 0 None 0 0 None 0 0 1.01759E-05 0 0
D/G 16991 Ig-111 37 rs745796006 0.1647 -0.811 0.955 N 0.511 0.281 0.173771789658 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
D/G 16991 Ig-111 37 rs745796006 0.1647 -0.811 0.955 N 0.511 0.281 0.173771789658 gnomAD-4.0.0 1.59338E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86202E-06 0 0
D/Y 16991 Ig-111 37 None 0.3243 None 1.0 D 0.659 0.373 0.632155945983 gnomAD-4.0.0 1.59338E-06 None None None None N None 0 0 None 0 2.78769E-05 None 0 0 0 0 0
D/E 17284 Ig-112 34 None 0.2867 None 0.625 N 0.488 0.135 0.285316908763 gnomAD-4.0.0 1.36947E-06 None None None None N None 0 0 None 0 2.53357E-05 None 0 0 8.9992E-07 0 0
D/N 17284 Ig-112 34 None 0.1103 None 0.002 N 0.228 0.135 0.16115917748 gnomAD-4.0.0 6.84735E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99923E-07 0 0
D/Y 17284 Ig-112 34 rs1309961194 0.4492 -0.339 0.989 N 0.665 0.416 0.512707719942 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
D/Y 17284 Ig-112 34 rs1309961194 0.4492 -0.339 0.989 N 0.665 0.416 0.512707719942 gnomAD-4.0.0 7.53208E-06 None None None None N None 0 0 None 0 0 None 0 0 9.89915E-06 0 0
A/S 18721 Ig-116 34 None 0.1193 None 1.0 N 0.593 0.261 0.350524144436 gnomAD-4.0.0 1.59343E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86193E-06 0 0
A/V 18721 Ig-116 34 rs1484664592 0.3558 None 1.0 N 0.646 0.334 0.573547766065 gnomAD-4.0.0 4.10764E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69948E-06 3.48254E-05 0
N/K 19129 Ig-117 35 rs375305621 0.4075 0.208 0.425 N 0.276 0.153 0.141422826196 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.57E-05 0
N/K 19129 Ig-117 35 rs375305621 0.4075 0.208 0.425 N 0.276 0.153 0.141422826196 gnomAD-3.1.2 1.32E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
N/K 19129 Ig-117 35 rs375305621 0.4075 0.208 0.425 N 0.276 0.153 0.141422826196 gnomAD-4.0.0 1.17774E-05 None None None None N None 0 0 None 0 0 None 0 0 1.52597E-05 0 1.60154E-05
E/G 19823 Ig-119 34 None 0.0763 None None N 0.188 0.071 0.104622674875 gnomAD-4.0.0 1.59182E-06 None None None None N None 0 2.28697E-05 None 0 0 None 0 0 0 0 0
E/K 19823 Ig-119 34 None 0.2347 None 0.117 N 0.286 0.176 0.190952846119 gnomAD-4.0.0 1.59184E-06 None None None None N None 5.66316E-05 0 None 0 0 None 0 0 0 0 0
D/E 20115 Ig-120 36 rs376618165 0.1254 0.016 0.767 N 0.238 0.076 0.229264304666 gnomAD-2.1.1 2.42E-05 None None None None N None 0 0 None 0 0 None 0 None 0 5.34E-05 0
D/E 20115 Ig-120 36 rs376618165 0.1254 0.016 0.767 N 0.238 0.076 0.229264304666 gnomAD-4.0.0 2.66927E-05 None None None None N None 0 0 None 0 0 None 0 0 3.41886E-05 0 1.65706E-05
D/G 20115 Ig-120 36 None 0.0929 None 0.998 N 0.638 0.418 0.282179105231 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 20115 Ig-120 36 rs369893671 0.0732 0.248 1.0 N 0.617 0.393 None gnomAD-2.1.1 2.5E-05 None None None None N None 1.65385E-04 0 None 0 5.13E-05 None 0 None 0 1.57E-05 0
D/N 20115 Ig-120 36 rs369893671 0.0732 0.248 1.0 N 0.617 0.393 None gnomAD-3.1.2 5.92E-05 None None None None N None 1.93134E-04 0 0 0 1.94477E-04 None 0 0 0 0 0
D/N 20115 Ig-120 36 rs369893671 0.0732 0.248 1.0 N 0.617 0.393 None gnomAD-4.0.0 1.98391E-05 None None None None N None 1.73667E-04 0 None 0 4.4615E-05 None 0 0 1.10223E-05 3.29678E-05 1.60174E-05
E/K 20513 Ig-121 35 None 0.4305 None 0.811 N 0.494 0.204 0.230578612272 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 3.66327E-05
D/G 20806 Ig-122 38 rs1425140267 0.226 -0.77 0.928 N 0.647 0.551 0.390374949789 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 6.55E-05 None 0 0 0
D/G 20806 Ig-122 38 rs1425140267 0.226 -0.77 0.928 N 0.647 0.551 0.390374949789 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
D/G 20806 Ig-122 38 rs1425140267 0.226 -0.77 0.928 N 0.647 0.551 0.390374949789 gnomAD-4.0.0 3.84655E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.0222E-05 0
V/A 21211 Ig-123 35 rs397517654 0.1293 None 0.565 N 0.434 0.225 0.367042808489 gnomAD-4.0.0 2.05364E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69916E-06 0 0
V/I 21211 Ig-123 35 None 0.0899 None 0.034 N 0.347 0.036 0.26169431596 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/E 21503 Ig-124 35 rs768027450 0.2361 -0.559 0.999 N 0.706 0.325 0.297031009988 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
G/E 21503 Ig-124 35 rs768027450 0.2361 -0.559 0.999 N 0.706 0.325 0.297031009988 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/R 21503 Ig-124 35 rs1559535271 0.5178 -0.326 0.999 N 0.707 0.394 0.484763619824 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
G/R 21503 Ig-124 35 rs1559535271 0.5178 -0.326 0.999 N 0.707 0.394 0.484763619824 gnomAD-4.0.0 1.59229E-06 None None None None N None 0 0 None 0 2.77408E-05 None 0 0 0 0 0
G/V 21503 Ig-124 35 None 0.4584 None 0.997 N 0.713 0.396 0.501308276186 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
P/S 22298 Ig-126 34 rs72646871 0.2115 -0.79 0.101 N 0.383 0.038 0.0920862733494 gnomAD-2.1.1 8.06E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 1.665E-04
P/S 22298 Ig-126 34 rs72646871 0.2115 -0.79 0.101 N 0.383 0.038 0.0920862733494 gnomAD-4.0.0 4.77931E-06 None None None None N None 0 2.28833E-05 None 0 0 None 0 0 2.86116E-06 0 3.02939E-05
A/T 22984 Ig-128 35 None 0.0963 None 0.505 N 0.422 0.145 0.107399877778 gnomAD-4.0.0 2.05334E-06 None None None None N None 0 0 None 0 2.52564E-05 None 0 0 0 2.3197E-05 0
D/N 23381 Ig-129 37 rs1559456668 0.1533 None 0.801 N 0.389 0.269 0.236278675362 gnomAD-4.0.0 3.19209E-06 None None None None I None 0 0 None 0 0 None 0 0 5.7405E-06 0 0
G/A 23670 Ig-130 34 None 0.1267 None 0.977 N 0.504 0.206 0.117506650769 gnomAD-4.0.0 6.84568E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99729E-07 0 0
G/R 23670 Ig-130 34 rs1709584700 0.2796 None 0.993 N 0.712 0.406 0.472504041403 gnomAD-4.0.0 1.59328E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02737E-05
G/V 23670 Ig-130 34 None 0.2488 None 0.997 N 0.737 0.291 0.519783508757 gnomAD-4.0.0 6.84568E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99729E-07 0 0
D/N 24066 Ig-131 38 rs1357579405 0.0882 0.335 0.007 N 0.215 0.124 0.222439326576 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
D/N 24066 Ig-131 38 rs1357579405 0.0882 0.335 0.007 N 0.215 0.124 0.222439326576 gnomAD-4.0.0 2.73767E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59853E-06 0 0
D/N 24465 Ig-132 35 rs764857452 0.1169 -0.567 0.001 N 0.347 0.162 0.162503812791 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 1.78E-05 0
D/N 24465 Ig-132 35 rs764857452 0.1169 -0.567 0.001 N 0.347 0.162 0.162503812791 gnomAD-4.0.0 1.1143E-05 None None None None N None 0 0 None 0 0 None 0 0 1.42976E-05 2.8659E-05 0
D/E 24752 Ig-133 37 None 0.2687 None 0.058 N 0.374 0.156 0.139678290688 gnomAD-4.0.0 1.5919E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02572E-05
D/G 24752 Ig-133 37 rs775906538 0.1708 -0.038 0.006 N 0.354 0.234 0.119812018005 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/G 24752 Ig-133 37 rs775906538 0.1708 -0.038 0.006 N 0.354 0.234 0.119812018005 gnomAD-4.0.0 1.59189E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43299E-05 0
D/N 24752 Ig-133 37 None 0.1471 None 0.822 N 0.477 0.389 0.181679512989 gnomAD-4.0.0 7.52769E-06 None None None None N None 0 0 None 0 0 None 0 0 9.89563E-06 0 0
D/Y 24752 Ig-133 37 rs747206654 0.424 -0.063 0.997 N 0.637 0.49 0.666639349654 gnomAD-2.1.1 8.05E-06 None None None None N None 6.49E-05 0 None 0 0 None 0 None 0 0 1.65948E-04
D/Y 24752 Ig-133 37 rs747206654 0.424 -0.063 0.997 N 0.637 0.49 0.666639349654 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/Y 24752 Ig-133 37 rs747206654 0.424 -0.063 0.997 N 0.637 0.49 0.666639349654 gnomAD-4.0.0 1.8595E-06 None None None None N None 2.67087E-05 0 None 0 0 None 0 0 0 0 1.60159E-05
G/C 25148 Ig-134 38 None 0.1977 None 0.008 N 0.492 0.18 0.344945010812 gnomAD-4.0.0 6.84303E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15937E-05 0
G/D 25148 Ig-134 38 rs1206394112 0.1234 None 0.001 N 0.3 0.12 0.0954503805726 gnomAD-3.1.2 1.32E-05 None None None None N None 0 1.31113E-04 0 0 0 None 0 0 0 0 0
G/D 25148 Ig-134 38 rs1206394112 0.1234 None 0.001 N 0.3 0.12 0.0954503805726 gnomAD-4.0.0 2.4792E-06 None None None None N None 0 5.00267E-05 None 0 0 None 0 0 8.47732E-07 0 0
G/R 25148 Ig-134 38 None 0.2866 None 0.003 N 0.365 0.13 0.277730125212 gnomAD-4.0.0 7.52734E-06 None None None None N None 0 0 None 0 0 None 0 0 9.89536E-06 0 0
G/S 25148 Ig-134 38 rs778131439 0.1174 -0.433 0.018 N 0.273 0.058 0.126345400529 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
G/S 25148 Ig-134 38 rs778131439 0.1174 -0.433 0.018 N 0.273 0.058 0.126345400529 gnomAD-4.0.0 5.47443E-06 None None None None N None 0 0 None 0 0 None 0 3.47102E-04 5.39747E-06 0 0
V/M 25547 Ig-135 34 rs1429730962 0.0735 -0.296 0.002 N 0.248 0.037 0.0666544352282 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 4.66E-05 8.9E-06 0
V/M 25547 Ig-135 34 rs1429730962 0.0735 -0.296 0.002 N 0.248 0.037 0.0666544352282 gnomAD-4.0.0 6.84674E-06 None None None None N None 0 4.47588E-05 None 0 0 None 0 0 6.29978E-06 0 1.65793E-05
G/V 26230 Ig-137 38 None 0.5007 None 1.0 N 0.754 0.364 0.493021045079 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/Q 26629 Ig-138 36 rs727504673 0.2214 0.498 0.322 N 0.303 0.186 0.1749357433 gnomAD-2.1.1 2.01E-05 None None None None I None 0 0 None 0 2.78583E-04 None 0 None 0 0 0
E/Q 26629 Ig-138 36 rs727504673 0.2214 0.498 0.322 N 0.303 0.186 0.1749357433 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/Q 26629 Ig-138 36 rs727504673 0.2214 0.498 0.322 N 0.303 0.186 0.1749357433 gnomAD-4.0.0 1.98316E-05 None None None None I None 0 0 None 0 4.90502E-04 None 0 0 8.4766E-06 0 0
E/V 26629 Ig-138 36 rs1705791323 0.2281 None 0.991 N 0.565 0.504 0.459552425292 gnomAD-4.0.0 1.59145E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85869E-06 0 0
A/T 27712 Ig-141 37 None 0.093 None 0.892 N 0.445 0.2 0.28492961333 gnomAD-4.0.0 1.59155E-06 None None None None I None 0 0 None 0 2.77454E-05 None 0 0 0 0 0
A/V 27712 Ig-141 37 None 0.1242 None 0.025 N 0.305 0.085 0.227260227426 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
D/V 27999 Ig-142 37 None 0.6275 None 0.999 N 0.691 0.538 0.547039986869 gnomAD-4.0.0 1.59269E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85994E-06 0 0
D/E 28394 Ig-143 37 rs1703423853 0.2958 None 1.0 N 0.437 0.296 0.336400405673 gnomAD-4.0.0 3.18256E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71621E-06 0 0
D/G 28394 Ig-143 37 rs751635229 0.1816 0.056 1.0 N 0.673 0.46 0.272205846399 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
D/G 28394 Ig-143 37 rs751635229 0.1816 0.056 1.0 N 0.673 0.46 0.272205846399 gnomAD-4.0.0 4.77386E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57442E-06 0 0
P/L 28791 Ig-144 37 None 0.1243 None 1.0 N 0.735 0.372 0.383089235449 gnomAD-4.0.0 1.626E-06 None None None None N None 0 0 None 0 0 None 0 0 2.91552E-06 0 0
D/E 29477 Ig-146 34 None 0.2654 None 0.977 N 0.381 0.206 0.202949470691 gnomAD-4.0.0 3.18292E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71608E-06 0 0
D/G 29477 Ig-146 34 None 0.1275 None 0.955 N 0.523 0.343 0.19670166235 gnomAD-4.0.0 6.84242E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65684E-05
D/H 29477 Ig-146 34 None 0.5165 None 0.999 N 0.6 0.344 0.26547132957 gnomAD-4.0.0 1.36849E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99449E-07 1.15939E-05 0
D/V 29477 Ig-146 34 rs777351270 0.5448 0.103 0.997 N 0.683 0.474 0.554315986709 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/V 29477 Ig-146 34 rs777351270 0.5448 0.103 0.997 N 0.683 0.474 0.554315986709 gnomAD-4.0.0 6.84242E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15939E-05 0
D/E 29876 Ig-147 35 rs397517743 0.1278 -0.017 None N 0.127 0.101 0.0716867268079 gnomAD-2.1.1 1.44E-05 None None None None N None 0 0 None 0 0 None 0 None 1.28811E-04 7.81E-06 0
D/E 29876 Ig-147 35 rs397517743 0.1278 -0.017 None N 0.127 0.101 0.0716867268079 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/E 29876 Ig-147 35 rs397517743 0.1278 -0.017 None N 0.127 0.101 0.0716867268079 gnomAD-4.0.0 1.67543E-05 None None None None N None 0 1.66661E-05 None 0 0 None 4.85814E-05 0 1.77995E-05 0 3.20277E-05
D/G 30168 Ig-148 37 rs1244536669 0.2993 None 1.0 N 0.686 0.491 0.236890367714 gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
D/G 30168 Ig-148 37 rs1244536669 0.2993 None 1.0 N 0.686 0.491 0.236890367714 gnomAD-4.0.0 1.31387E-05 None None None None N None 4.823E-05 0 None 0 0 None 0 0 0 0 0
P/A 30962 Ig-150 36 None 0.0728 None None N 0.157 0.06 0.0986583533028 gnomAD-4.0.0 6.84261E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99459E-07 0 0
P/S 30962 Ig-150 36 None 0.1156 None 0.166 N 0.361 0.04 0.110078149338 gnomAD-4.0.0 4.10557E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39675E-06 0 0
G/R 31652 Ig-152 32 None 0.5201 None 1.0 N 0.649 0.51 0.298403945805 gnomAD-4.0.0 1.59128E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85842E-06 0 0
Q/R 32051 Ig-153 35 rs767383259 0.0899 0.483 0.012 N 0.225 0.122 0.148003135375 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
A/G 32343 Ig-154 37 None 0.0749 None None N 0.125 0.095 0.132336055621 gnomAD-4.0.0 1.59124E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85829E-06 0 0
A/T 32343 Ig-154 37 rs539206860 0.1246 None 0.062 N 0.243 0.032 0.107399877778 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 32343 Ig-154 37 rs539206860 0.1246 None 0.062 N 0.243 0.032 0.107399877778 gnomAD-4.0.0 2.56249E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78631E-06 0 0
E/K 32741 Ig-155 34 rs1693522689 0.3135 None 0.822 N 0.521 0.255 0.215869574891 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/K 32741 Ig-155 34 rs1693522689 0.3135 None 0.822 N 0.521 0.255 0.215869574891 gnomAD-4.0.0 2.56216E-06 None None None None N None 0 1.69515E-05 None 0 0 None 0 0 2.39294E-06 0 0
G/D 33233 Ig-157 31 rs1271698749 0.1456 -0.45 0.134 N 0.533 0.137 0.107399877778 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 9.94E-05 0 None 0 None 0 0 0
G/D 33233 Ig-157 31 rs1271698749 0.1456 -0.45 0.134 N 0.533 0.137 0.107399877778 gnomAD-4.0.0 1.59138E-06 None None None None N None 0 0 None 4.76735E-05 0 None 0 0 0 0 0
G/R 33233 Ig-157 31 rs1479703303 0.3201 -0.478 0.995 N 0.737 0.425 0.561714622075 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
G/R 33233 Ig-157 31 rs1479703303 0.3201 -0.478 0.995 N 0.737 0.425 0.561714622075 gnomAD-4.0.0 6.84235E-07 None None None None N None 0 2.23674E-05 None 0 0 None 0 0 0 0 0
G/S 33233 Ig-157 31 rs1479703303 0.1181 None 0.946 N 0.668 0.331 0.170165803431 gnomAD-4.0.0 2.73694E-06 None None None None N None 2.98829E-05 0 None 0 0 None 0 0 1.79899E-06 0 1.65667E-05
G/D 34173 Ig-160 37 rs752184554 0.8544 0.377 1.0 N 0.676 0.487 0.376570364461 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.66E-05 0
G/D 34173 Ig-160 37 rs752184554 0.8544 0.377 1.0 N 0.676 0.487 0.376570364461 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
G/D 34173 Ig-160 37 rs752184554 0.8544 0.377 1.0 N 0.676 0.487 0.376570364461 gnomAD-4.0.0 2.97435E-05 None None None None I None 0 0 None 0 0 None 0 0 4.06832E-05 0 0
D/H 34399 Ig-162 37 rs1268716038 0.9477 0.205 1.0 D 0.554 0.804 0.558070701127 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
D/H 34399 Ig-162 37 rs1268716038 0.9477 0.205 1.0 D 0.554 0.804 0.558070701127 gnomAD-4.0.0 1.36838E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79884E-06 0 0
D/N 34399 Ig-162 37 None 0.2103 None 1.0 N 0.589 0.471 0.47409059586 gnomAD-4.0.0 6.84189E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99418E-07 0 0
D/Y 34399 Ig-162 37 None 0.9006 None 1.0 D 0.593 0.79 0.756753278458 gnomAD-4.0.0 8.89446E-06 None None None None N None 0 0 None 0 0 None 0 0 1.16924E-05 0 0
N/D 34978 Ig-163 37 rs1343194230 0.2666 0.153 0.999 N 0.583 0.405 0.143124449307 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
N/D 34978 Ig-163 37 rs1343194230 0.2666 0.153 0.999 N 0.583 0.405 0.143124449307 gnomAD-4.0.0 3.18182E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85757E-06 0 3.02334E-05
N/S 34978 Ig-163 37 rs780028847 0.1888 -0.418 0.999 N 0.547 0.422 0.177238962908 gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 3.54E-05 0
N/S 34978 Ig-163 37 rs780028847 0.1888 -0.418 0.999 N 0.547 0.422 0.177238962908 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/S 34978 Ig-163 37 rs780028847 0.1888 -0.418 0.999 N 0.547 0.422 0.177238962908 gnomAD-4.0.0 6.1961E-06 None None None None N None 0 0 None 0 0 None 0 0 5.08525E-06 4.39116E-05 0
K/E 35165 Ig-164 37 rs879156291 0.0854 None None N 0.113 0.073 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/E 35165 Ig-164 37 rs879156291 0.0854 None None N 0.113 0.073 None gnomAD-4.0.0 2.02984E-06 None None None None N None 3.49504E-05 0 None 0 0 None 0 0 0 0 0
K/T 35165 Ig-164 37 None 0.1276 None None N 0.233 0.043 0.0846915920261 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
D/V 35456 Ig-166 37 rs1288351302 0.6146 -0.056 1.0 N 0.673 0.495 0.516326692288 gnomAD-4.0.0 1.64028E-06 None None None None N None 0 2.48188E-05 None 0 0 None 0 0 0 0 0
N/H 35641 Ig-167 35 None 0.3077 None 0.999 N 0.633 0.371 0.302459207581 gnomAD-4.0.0 2.73661E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59761E-06 0 0
N/K 35641 Ig-167 35 None 0.6959 None 0.117 N 0.425 0.077 0.110078149338 gnomAD-4.0.0 4.80129E-06 None None None None I None 0 0 None 0 2.75482E-04 None 0 0 3.9375E-06 0 0
N/K 35738 Ig-168 37 None 0.7534 None 0.117 N 0.322 0.132 0.115124310173 gnomAD-4.0.0 1.60895E-06 None None None None N None 0 0 None 0 0 None 0 0 2.89233E-06 0 0
N/S 35738 Ig-168 37 rs774996138 0.2351 0.26 0.027 N 0.385 0.157 0.112648838833 gnomAD-2.1.1 1.23E-05 None None None None N None 0 0 None 0 0 None 1.001E-04 None 0 0 0
N/S 35738 Ig-168 37 rs774996138 0.2351 0.26 0.027 N 0.385 0.157 0.112648838833 gnomAD-4.0.0 8.24405E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.40236E-04 0
G/D 35933 Ig-169 37 rs1686762598 0.1875 None 0.497 N 0.407 0.172 0.0762999501168 gnomAD-3.1.2 1.31E-05 None None None 0.897(OBSL1) 0.058(OBSCN) N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
G/D 35933 Ig-169 37 rs1686762598 0.1875 None 0.497 N 0.407 0.172 0.0762999501168 gnomAD-4.0.0 5.12338E-06 None None None 0.897(OBSL1) 0.058(OBSCN) N None 3.38238E-05 0 None 0 0 None 0 0 4.7849E-06 0 0
G/R 35933 Ig-169 37 rs1575170417 0.1224 None 0.002 N 0.394 0.067 0.225902525712 gnomAD-4.0.0 1.20032E-06 None None None 0.188(OBSL1) -0.494(OBSCN) N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.