Structural position:

  • Domain Type: Ig
  • Aligned Position: 59
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
Q/K 145 Ig-2 42 None 0.1731 None 0.001 N 0.239 0.23 0.167679373172 gnomAD-4.0.0 1.59047E-06 None None None -0.216(TCAP) N None 0 0 None 0 0 None 0 0 2.85649E-06 0 0
E/G 984 Ig-3 42 rs768091037 0.4289 -0.043 1.0 N 0.651 0.478 0.63470690541 gnomAD-2.1.1 5.32E-05 None None None None I None 0 0 None 0 0 None 0 None 5.57236E-04 7.78E-06 0
E/G 984 Ig-3 42 rs768091037 0.4289 -0.043 1.0 N 0.651 0.478 0.63470690541 gnomAD-3.1.2 3.94E-05 None None None None I None 0 0 0 0 0 None 5.64546E-04 0 0 0 0
E/G 984 Ig-3 42 rs768091037 0.4289 -0.043 1.0 N 0.651 0.478 0.63470690541 gnomAD-4.0.0 2.35434E-05 None None None None I None 0 0 None 0 0 None 5.46465E-04 0 1.6949E-06 0 1.60036E-05
E/K 984 Ig-3 42 rs753071669 0.3112 0.856 1.0 N 0.621 0.403 0.461671691612 gnomAD-2.1.1 7.98E-06 None None None None I None 0 0 None 0 5.45E-05 None 0 None 0 8.84E-06 0
E/K 984 Ig-3 42 rs753071669 0.3112 0.856 1.0 N 0.621 0.403 0.461671691612 gnomAD-4.0.0 4.77169E-06 None None None None I None 0 0 None 0 0 None 0 0 8.56991E-06 0 0
T/A 1123 Ig-4 42 None 0.3376 None 0.898 N 0.481 0.212 0.281381271821 gnomAD-4.0.0 1.59055E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
T/N 1123 Ig-4 42 None 0.5078 None 0.993 N 0.569 0.273 0.47737504017 gnomAD-4.0.0 6.8408E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99308E-07 0 0
T/S 1123 Ig-4 42 rs773799748 0.3491 -0.067 0.362 N 0.299 0.187 0.218845423259 gnomAD-2.1.1 2.79E-05 None None None None N None 0 0 None 6.95825E-04 0 None 0 None 0 0 0
T/S 1123 Ig-4 42 rs773799748 0.3491 -0.067 0.362 N 0.299 0.187 0.218845423259 gnomAD-3.1.2 7.23E-05 None None None None N None 0 0 0 2.88184E-03 0 None 0 0 1.47E-05 0 0
T/S 1123 Ig-4 42 rs773799748 0.3491 -0.067 0.362 N 0.299 0.187 0.218845423259 gnomAD-4.0.0 3.18111E-06 None None None None N None 0 4.57247E-05 None 0 0 None 0 0 0 0 0
V/A 1498 Ig-6 42 rs878871703 0.2536 None 0.645 N 0.443 0.244 0.595953376904 gnomAD-4.0.0 4.78917E-06 None None None None I None 0 0 None 0 0 None 0 0 5.39616E-06 0 1.65607E-05
V/D 1498 Ig-6 42 rs878871703 0.492 -0.365 0.928 N 0.663 0.552 0.845142582465 gnomAD-2.1.1 3.18E-05 None None None None I None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
V/D 1498 Ig-6 42 rs878871703 0.492 -0.365 0.928 N 0.663 0.552 0.845142582465 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/D 1498 Ig-6 42 rs878871703 0.492 -0.365 0.928 N 0.663 0.552 0.845142582465 gnomAD-4.0.0 6.56996E-06 None None None None I None 2.41196E-05 0 None 0 0 None 0 0 0 0 0
V/I 1498 Ig-6 42 None 0.0773 None 0.006 N 0.3 0.033 0.433936292671 gnomAD-4.0.0 1.59105E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85714E-06 0 0
V/L 1597 Ig-7 42 rs878928245 0.4645 None 0.08 N 0.235 0.12 0.486494567076 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/L 1597 Ig-7 42 rs878928245 0.4645 None 0.08 N 0.235 0.12 0.486494567076 gnomAD-4.0.0 2.47836E-06 None None None None N None 4.00502E-05 1.66678E-05 None 0 0 None 0 0 0 0 0
R/C 1882 Ig-9 42 rs397517658 0.9165 -0.199 1.0 D 0.649 0.597 0.731740448394 gnomAD-2.1.1 2.12E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 3.88E-05 0
R/C 1882 Ig-9 42 rs397517658 0.9165 -0.199 1.0 D 0.649 0.597 0.731740448394 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
R/C 1882 Ig-9 42 rs397517658 0.9165 -0.199 1.0 D 0.649 0.597 0.731740448394 gnomAD-4.0.0 2.72615E-05 None None None None N None 5.34017E-05 0 None 0 0 None 0 4.93097E-04 2.7966E-05 3.29345E-05 1.60046E-05
R/H 1882 Ig-9 42 rs374605213 0.7433 -0.742 0.783 N 0.336 0.342 None gnomAD-2.1.1 6.37E-05 None None None None N None 0 1.69367E-04 None 0 0 None 1.63313E-04 None 3.98E-05 4.66E-05 0
R/H 1882 Ig-9 42 rs374605213 0.7433 -0.742 0.783 N 0.336 0.342 None gnomAD-3.1.2 1.77424E-04 None None None None N None 4.83E-05 8.51008E-04 0 2.88351E-04 1.92382E-04 None 9.43E-05 0 1.32287E-04 0 0
R/H 1882 Ig-9 42 rs374605213 0.7433 -0.742 0.783 N 0.336 0.342 None gnomAD-4.0.0 5.20447E-05 None None None None N None 2.66951E-05 3.16667E-04 None 6.7563E-05 2.22737E-05 None 3.12402E-05 0 3.30511E-05 1.31744E-04 1.12029E-04
R/S 1882 Ig-9 42 None 0.9831 None 0.998 N 0.532 0.561 0.497280371566 gnomAD-4.0.0 6.84077E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99306E-07 0 0
E/Q 2119 Ig-10 42 rs869312098 0.1542 None 1.0 N 0.555 0.318 0.375326005269 gnomAD-4.0.0 4.77242E-06 None None None None N None 0 0 None 0 2.77593E-05 None 0 0 5.71327E-06 0 0
H/R 2215 Ig-11 42 rs778552915 0.064 0.106 0.096 N 0.28 0.123 0.200317383148 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 5.45E-05 None 0 None 0 0 0
H/R 2215 Ig-11 42 rs778552915 0.064 0.106 0.096 N 0.28 0.123 0.200317383148 gnomAD-4.0.0 1.59074E-06 None None None None N None 0 0 None 0 2.77562E-05 None 0 0 0 0 0
K/T 2307 Ig-12 41 rs1327919896 0.0964 0.076 0.001 N 0.148 0.276 0.307016933798 gnomAD-2.1.1 3.18E-05 None None None None N None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
K/T 2307 Ig-12 41 rs1327919896 0.0964 0.076 0.001 N 0.148 0.276 0.307016933798 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/T 2307 Ig-12 41 rs1327919896 0.0964 0.076 0.001 N 0.148 0.276 0.307016933798 gnomAD-4.0.0 6.57047E-06 None None None None N None 2.41301E-05 0 None 0 0 None 0 0 0 0 0
Q/L 2396 Ig-13 41 None 0.0773 None 0.175 N 0.381 0.209 0.40722173914 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/N 2573 Ig-15 41 rs2091795391 0.3958 None 0.22 D 0.447 0.162 0.191931220699 gnomAD-4.0.0 6.84166E-07 None None None None N None 0 2.23774E-05 None 0 0 None 0 0 0 0 0
K/R 2573 Ig-15 41 rs113405975 0.0977 None 0.124 N 0.483 0.201 0.359557344763 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/E 3098 Ig-21 41 None 0.094 None 0.001 N 0.177 0.167 0.168933306366 gnomAD-4.0.0 3.42037E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49647E-06 0 0
N/S 3187 Ig-22 41 None 0.1352 None 0.826 N 0.4 0.168 0.287603790349 gnomAD-4.0.0 1.20033E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
S/C 3280 Ig-23 42 None 0.3035 None 1.0 D 0.492 0.497 0.498387242485 gnomAD-4.0.0 6.84067E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99294E-07 0 0
S/F 3280 Ig-23 42 rs747768723 0.4917 -0.863 0.999 D 0.569 0.545 0.659558603232 gnomAD-2.1.1 7.08E-06 None None None None I None 0 0 None 0 0 None 0 None 0 7.77E-06 1.38658E-04
S/F 3280 Ig-23 42 rs747768723 0.4917 -0.863 0.999 D 0.569 0.545 0.659558603232 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 3.16456E-03 0 0 0
S/F 3280 Ig-23 42 rs747768723 0.4917 -0.863 0.999 D 0.569 0.545 0.659558603232 gnomAD-4.0.0 1.85869E-06 None None None None I None 0 0 None 0 0 None 0 1.6442E-04 1.69489E-06 0 0
S/P 3280 Ig-23 42 None 0.349 None 0.999 N 0.43 0.514 0.377976839388 gnomAD-4.0.0 1.59049E-06 None None None None I None 0 0 None 0 2.77331E-05 None 0 0 0 0 0
S/Y 3280 Ig-23 42 rs747768723 0.4639 -0.595 0.999 D 0.569 0.558 0.679525051678 gnomAD-2.1.1 3.98E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.82E-06 0
S/Y 3280 Ig-23 42 rs747768723 0.4639 -0.595 0.999 D 0.569 0.558 0.679525051678 gnomAD-4.0.0 4.1044E-06 None None None None I None 0 0 None 0 0 None 0 0 5.39576E-06 0 0
E/K 3701 Ig-26 42 rs1306774376 0.0799 0.685 None None None 0.052 None gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
E/K 3701 Ig-26 42 rs1306774376 0.0799 0.685 None None None 0.052 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 3701 Ig-26 42 rs1306774376 0.0799 0.685 None None None 0.052 None gnomAD-4.0.0 2.56195E-06 None None None None N None 0 0 None 0 0 None 0 0 2.39271E-06 1.33991E-05 0
T/I 3861 Ig-27 42 rs1214393200 0.1162 0.003 0.015 N 0.22 0.121 None gnomAD-2.1.1 3.18E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/I 3861 Ig-27 42 rs1214393200 0.1162 0.003 0.015 N 0.22 0.121 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 3861 Ig-27 42 rs1214393200 0.1162 0.003 0.015 N 0.22 0.121 None gnomAD-4.0.0 6.57134E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47016E-05 0 0
C/R 3979 Ig-28 42 None 0.1631 None 0.025 N 0.427 0.176 None gnomAD-4.0.0 8.40227E-06 None None None None I None 0 0 None 0 0 None 0 0 9.18753E-06 0 0
S/P 4836 Ig-31 42 None 0.0826 None 0.003 N 0.3 0.126 0.143124449307 gnomAD-4.0.0 1.59116E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85811E-06 0 0
S/T 4836 Ig-31 42 None 0.0858 None 0.505 N 0.443 0.091 0.171388866994 gnomAD-4.0.0 1.59116E-06 None None None None N None 0 0 None 0 0 None 1.88246E-05 0 0 0 0
P/A 4929 Ig-32 42 rs2081317152 0.069 None 0.625 N 0.289 0.418 0.279370189704 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/A 4929 Ig-32 42 rs2081317152 0.069 None 0.625 N 0.289 0.418 0.279370189704 gnomAD-4.0.0 6.57229E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47011E-05 0 0
P/S 4929 Ig-32 42 None 0.0815 None 0.891 N 0.273 0.417 0.286848849266 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
S/N 5023 Ig-33 43 rs878907513 0.0707 0.065 None N 0.125 0.134 None gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
S/N 5023 Ig-33 43 rs878907513 0.0707 0.065 None N 0.125 0.134 None gnomAD-4.0.0 1.98436E-05 None None None None N None 2.98793E-05 0 None 0 0 None 0 0 2.42863E-05 0 1.65673E-05
R/L 5116 Ig-34 42 rs769626460 0.561 0.302 0.967 N 0.401 0.362 0.62232872579 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
R/L 5116 Ig-34 42 rs769626460 0.561 0.302 0.967 N 0.401 0.362 0.62232872579 gnomAD-4.0.0 6.84277E-07 None None None None N None 0 0 None 0 2.52156E-05 None 0 0 0 0 0
R/P 5116 Ig-34 42 rs769626460 0.7607 0.065 0.995 N 0.376 0.422 0.523650220922 gnomAD-4.0.0 6.84277E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65656E-05
R/Q 5116 Ig-34 42 None 0.2963 -0.031 0.992 N 0.393 0.271 0.248417906384 gnomAD-2.1.1 8.05E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.89E-06 0
R/Q 5116 Ig-34 42 None 0.2963 -0.031 0.992 N 0.393 0.271 0.248417906384 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/Q 5116 Ig-34 42 None 0.2963 -0.031 0.992 N 0.393 0.271 0.248417906384 gnomAD-4.0.0 6.19745E-06 None None None None N None 1.33494E-05 1.66744E-05 None 0 0 None 0 0 6.78117E-06 0 0
R/G 5209 Ig-35 42 rs1392727449 0.0978 -0.11 0.117 N 0.411 0.127 0.453401982733 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
R/G 5209 Ig-35 42 rs1392727449 0.0978 -0.11 0.117 N 0.411 0.127 0.453401982733 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/G 5209 Ig-35 42 rs1392727449 0.0978 -0.11 0.117 N 0.411 0.127 0.453401982733 gnomAD-4.0.0 2.56194E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78588E-06 0 0
R/K 5209 Ig-35 42 None 0.057 None None N 0.179 0.086 0.136095386433 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/D 5302 Ig-36 42 None 0.2731 None 0.213 N 0.417 0.288 0.625243557465 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 5302 Ig-36 42 rs1410470675 0.0794 None 0.001 N 0.166 0.045 0.28058544554 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 5302 Ig-36 42 rs1410470675 0.0794 None 0.001 N 0.166 0.045 0.28058544554 gnomAD-4.0.0 2.5624E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78618E-06 0 0
V/A 5491 Ig-38 42 None 0.0929 None 0.001 N 0.135 0.137 0.424430313326 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/L 5491 Ig-38 42 rs1460594860 0.1 None None N 0.132 0.134 0.268211541103 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
V/L 5491 Ig-38 42 rs1460594860 0.1 None None N 0.132 0.134 0.268211541103 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 3.861E-04 None 0 0 0 0 0
V/L 5491 Ig-38 42 rs1460594860 0.1 None None N 0.132 0.134 0.268211541103 gnomAD-4.0.0 6.40567E-06 None None None None N None 0 0 None 0 1.21412E-04 None 0 0 0 0 0
K/T 5585 Ig-39 43 rs1180216660 0.1024 0.184 0.001 N 0.189 0.276 0.27855597813 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.67019E-04 None 0 None 0 0 0
K/T 5585 Ig-39 43 rs1180216660 0.1024 0.184 0.001 N 0.189 0.276 0.27855597813 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92976E-04 None 0 0 0 0 0
K/T 5585 Ig-39 43 rs1180216660 0.1024 0.184 0.001 N 0.189 0.276 0.27855597813 gnomAD-4.0.0 5.12397E-06 None None None None N None 0 0 None 0 9.69885E-05 None 0 0 0 0 0
R/P 5678 Ig-40 42 None 0.6125 None 0.156 N 0.315 0.279 0.317958651998 gnomAD-4.0.0 6.8421E-07 None None None None I None 0 0 None 0 2.5194E-05 None 0 0 0 0 0
R/Q 5678 Ig-40 42 rs374742663 0.1904 -0.109 0.992 N 0.491 0.24 None gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 8.89E-06 0
R/Q 5678 Ig-40 42 rs374742663 0.1904 -0.109 0.992 N 0.491 0.24 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 1.92753E-04 None 0 0 2.94E-05 0 0
R/Q 5678 Ig-40 42 rs374742663 0.1904 -0.109 0.992 N 0.491 0.24 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
R/Q 5678 Ig-40 42 rs374742663 0.1904 -0.109 0.992 N 0.491 0.24 None gnomAD-4.0.0 6.19668E-06 None None None None I None 0 0 None 0 2.22876E-05 None 0 0 4.23815E-06 4.39194E-05 0
T/A 5771 Ig-41 42 None 0.0669 None 0.002 N 0.096 0.125 0.139678290688 gnomAD-4.0.0 1.59134E-06 None None None None N None 0 0 None 0 2.77423E-05 None 0 0 0 0 0
T/I 5771 Ig-41 42 rs16866477 0.0824 None None N 0.136 0.131 0.28722502521 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 5771 Ig-41 42 rs16866477 0.0824 None None N 0.136 0.131 0.28722502521 gnomAD-4.0.0 6.5741E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47003E-05 0 0
T/S 5771 Ig-41 42 rs16866477 0.0913 -0.089 0.061 N 0.193 0.099 0.128392430309 gnomAD-2.1.1 1.93163E-03 None None None None N None 2.07627E-02 7.36252E-04 None 0 0 None 0 None 0 6.25E-05 7.02642E-04
T/S 5771 Ig-41 42 rs16866477 0.0913 -0.089 0.061 N 0.193 0.099 0.128392430309 gnomAD-3.1.2 5.81808E-03 None None None None N None 2.04491E-02 9.82833E-04 0 0 0 None 0 3.16456E-03 1.02902E-04 0 7.18391E-03
T/S 5771 Ig-41 42 rs16866477 0.0913 -0.089 0.061 N 0.193 0.099 0.128392430309 1000 genomes 5.79073E-03 None None None None N None 2.04E-02 2.9E-03 None None 0 0 None None None 0 None
T/S 5771 Ig-41 42 rs16866477 0.0913 -0.089 0.061 N 0.193 0.099 0.128392430309 gnomAD-4.0.0 1.12534E-03 None None None None N None 2.16394E-02 9.50285E-04 None 0 0 None 0 1.32013E-03 1.94951E-05 4.39174E-05 1.61678E-03
S/A 5960 Ig-43 42 None 0.0563 None 0.001 N 0.189 0.049 0.119812018005 gnomAD-4.0.0 1.5915E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85883E-06 0 0
H/N 6053 Ig-44 42 None 0.0824 None 0.302 N 0.265 0.142 0.272205846399 gnomAD-4.0.0 6.84406E-07 None None None None N None 0 2.23924E-05 None 0 0 None 0 0 0 0 0
H/Q 6053 Ig-44 42 None 0.0951 None 0.68 N 0.272 0.111 0.202949470691 gnomAD-4.0.0 4.10632E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39751E-06 0 0
R/L 6240 Ig-46 42 rs761993856 0.2506 0.295 0.837 N 0.373 0.243 0.622442570095 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
R/L 6240 Ig-46 42 rs761993856 0.2506 0.295 0.837 N 0.373 0.243 0.622442570095 gnomAD-4.0.0 6.84279E-07 None None None None N None 0 2.23714E-05 None 0 0 None 0 0 0 0 0
R/Q 6240 Ig-46 42 rs761993856 0.1177 0.003 0.958 N 0.417 0.162 0.237489013734 gnomAD-2.1.1 1.32317E-04 None None None None N None 0 0 None 0 1.69127E-03 None 0 None 0 2.35E-05 1.40568E-04
R/Q 6240 Ig-46 42 rs761993856 0.1177 0.003 0.958 N 0.417 0.162 0.237489013734 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 7.72798E-04 None 0 0 1.47E-05 0 0
R/Q 6240 Ig-46 42 rs761993856 0.1177 0.003 0.958 N 0.417 0.162 0.237489013734 gnomAD-4.0.0 4.21451E-05 None None None None N None 2.67058E-05 0 None 0 1.27045E-03 None 0 0 4.23856E-06 1.09791E-05 4.804E-05
D/Y 6333 Ig-47 42 rs1275885460 0.1114 0.21 0.741 N 0.364 0.237 0.467161347466 gnomAD-2.1.1 4.06E-06 None None None None I None 0 2.92E-05 None 0 0 None 0 None 0 0 0
D/Y 6333 Ig-47 42 rs1275885460 0.1114 0.21 0.741 N 0.364 0.237 0.467161347466 gnomAD-4.0.0 1.59366E-06 None None None None I None 0 2.2941E-05 None 0 0 None 0 0 0 0 0
V/F 6426 Ig-48 42 rs778339438 0.1346 None 0.351 N 0.453 0.278 0.784326782449 gnomAD-4.0.0 1.16351E-05 None None None None N None 0 0 None 0 0 None 0 0 1.52934E-05 0 0
V/I 6426 Ig-48 42 rs778339438 0.0788 None 0.003 N 0.217 0.06 0.551508998025 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
V/I 6426 Ig-48 42 rs778339438 0.0788 None 0.003 N 0.217 0.06 0.551508998025 gnomAD-4.0.0 3.42207E-06 None None None None N None 2.98954E-05 0 None 0 0 None 0 0 3.59844E-06 0 0
S/P 6522 Ig-49 42 rs780721181 0.0928 -0.477 0.001 N 0.235 0.264 0.168933306366 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/P 6522 Ig-49 42 rs780721181 0.0928 -0.477 0.001 N 0.235 0.264 0.168933306366 gnomAD-4.0.0 1.59238E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43312E-05 0
S/Y 6522 Ig-49 42 rs768370268 0.1204 -0.601 0.272 D 0.414 0.257 0.580281640613 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
S/Y 6522 Ig-49 42 rs768370268 0.1204 -0.601 0.272 D 0.414 0.257 0.580281640613 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/Y 6522 Ig-49 42 rs768370268 0.1204 -0.601 0.272 D 0.414 0.257 0.580281640613 gnomAD-4.0.0 1.85969E-06 None None None None N None 1.33568E-05 0 None 0 0 None 0 0 1.6956E-06 0 0
V/L 6615 Ig-50 42 None 0.096 None None N 0.093 0.066 0.443388199986 gnomAD-4.0.0 8.21269E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99698E-06 0 3.31422E-05
P/S 6709 Ig-51 43 None 0.0717 None None N 0.147 0.126 0.0920862733494 gnomAD-4.0.0 3.18517E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86082E-06 0 3.02682E-05
R/K 6896 Ig-53 43 rs1026814261 0.15 None 0.4 N 0.267 0.19 0.282575091529 gnomAD-4.0.0 3.42217E-06 None None None None N None 2.99115E-05 0 None 0 0 None 0 0 1.79936E-06 0 3.31433E-05
R/S 6896 Ig-53 43 None 0.5515 None 0.98 N 0.577 0.332 0.490839437361 gnomAD-4.0.0 1.59236E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86026E-06 0 0
T/S 6989 Ig-54 42 rs1228987960 0.0902 -0.135 0.159 N 0.084 0.07 0.149567049428 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/S 6989 Ig-54 42 rs1228987960 0.0902 -0.135 0.159 N 0.084 0.07 0.149567049428 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/S 6989 Ig-54 42 rs1228987960 0.0902 -0.135 0.159 N 0.084 0.07 0.149567049428 gnomAD-4.0.0 6.57333E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47059E-05 0 0
V/F 7085 Ig-55 42 rs1477979232 0.0984 None 0.863 N 0.367 0.297 0.806042141942 gnomAD-4.0.0 1.59192E-06 None None None None N None 0 0 None 0 2.775E-05 None 0 0 0 0 0
V/G 7085 Ig-55 42 rs762099144 0.1393 -0.453 0.473 N 0.421 0.214 0.751175389254 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/G 7085 Ig-55 42 rs762099144 0.1393 -0.453 0.473 N 0.421 0.214 0.751175389254 gnomAD-4.0.0 3.1838E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86599E-05 0
V/L 7178 Ig-56 42 rs753557450 0.1038 -0.2 0.002 N 0.09 0.2 0.385249989106 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
V/L 7178 Ig-56 42 rs753557450 0.1038 -0.2 0.002 N 0.09 0.2 0.385249989106 gnomAD-4.0.0 1.59227E-06 None None None None N None 0 2.28812E-05 None 0 0 None 0 0 0 0 0
V/M 7178 Ig-56 42 rs753557450 0.1109 -0.528 0.016 D 0.193 0.166 0.440182696023 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
V/M 7178 Ig-56 42 rs753557450 0.1109 -0.528 0.016 D 0.193 0.166 0.440182696023 gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
V/M 7178 Ig-56 42 rs753557450 0.1109 -0.528 0.016 D 0.193 0.166 0.440182696023 gnomAD-4.0.0 3.84532E-06 None None None None N None 3.38318E-05 0 None 0 0 None 0 0 2.39426E-06 0 0
T/A 7271 Ig-57 42 None 0.0678 None None D 0.131 0.09 0.0297737177859 gnomAD-4.0.0 3.3609E-05 None None None None N None 0 0 None 0 0 None 0 0 3.675E-05 0 0
R/P 7364 Ig-58 42 rs200128066 0.7241 None 1.0 N 0.561 0.393 0.53046153047 gnomAD-4.0.0 6.8439E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9962E-07 0 0
R/Q 7364 Ig-58 42 rs200128066 0.2018 0.153 1.0 N 0.507 0.269 None gnomAD-2.1.1 4.65E-05 None None None None N None 8.27E-05 2.84E-05 None 0 0 None 0 None 0 7.82E-05 0
R/Q 7364 Ig-58 42 rs200128066 0.2018 0.153 1.0 N 0.507 0.269 None gnomAD-3.1.2 9.87E-05 None None None None N None 7.25E-05 1.31406E-04 0 0 0 None 0 0 1.47141E-04 0 0
R/Q 7364 Ig-58 42 rs200128066 0.2018 0.153 1.0 N 0.507 0.269 None gnomAD-4.0.0 8.12105E-05 None None None None N None 5.34545E-05 6.67713E-05 None 0 2.22995E-05 None 1.56411E-05 0 1.00039E-04 0 4.80631E-05
R/W 7364 Ig-58 42 rs397517500 0.2451 -0.363 1.0 N 0.61 0.585 0.476522311808 gnomAD-2.1.1 9.65E-05 None None None None N None 4.14E-05 1.4178E-04 None 9.67E-05 0 None 5.89082E-04 None 0 1.56E-05 0
R/W 7364 Ig-58 42 rs397517500 0.2451 -0.363 1.0 N 0.61 0.585 0.476522311808 gnomAD-3.1.2 1.18418E-04 None None None None N None 4.83E-05 4.59318E-04 0 0 0 None 0 0 8.83E-05 6.22148E-04 0
R/W 7364 Ig-58 42 rs397517500 0.2451 -0.363 1.0 N 0.61 0.585 0.476522311808 gnomAD-4.0.0 6.50913E-05 None None None None N None 4.00716E-05 3.17079E-04 None 0 0 None 1.56402E-05 0 3.22167E-05 4.50312E-04 4.80677E-05
R/C 7556 Ig-60 42 rs754885396 0.4466 -0.215 0.999 N 0.315 0.401 0.60023526351 gnomAD-2.1.1 8.93E-05 None None None None N None 2.06731E-04 4.81859E-04 None 0 5.13E-05 None 0 None 0 7.81E-06 1.40687E-04
R/C 7556 Ig-60 42 rs754885396 0.4466 -0.215 0.999 N 0.315 0.401 0.60023526351 gnomAD-3.1.2 5.26E-05 None None None None N None 1.93162E-04 0 0 0 0 None 0 0 0 0 0
R/C 7556 Ig-60 42 rs754885396 0.4466 -0.215 0.999 N 0.315 0.401 0.60023526351 gnomAD-4.0.0 2.5413E-05 None None None None N None 1.60286E-04 3.50198E-04 None 0 2.22886E-05 None 0 0 4.23883E-06 1.09827E-05 1.60159E-05
R/G 7556 Ig-60 42 None 0.7094 None 0.839 N 0.371 0.261 0.519079548728 gnomAD-4.0.0 6.84332E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.1598E-05 0
R/H 7556 Ig-60 42 rs374344734 0.1804 -0.799 0.99 N 0.347 0.23 None gnomAD-2.1.1 9.63E-05 None None None None N None 3.30797E-04 2.83E-05 None 0 5.12E-05 None 4.25059E-04 None 0 2.34E-05 1.40489E-04
R/H 7556 Ig-60 42 rs374344734 0.1804 -0.799 0.99 N 0.347 0.23 None gnomAD-3.1.2 9.2E-05 None None None None N None 2.41336E-04 0 0 0 0 None 0 0 1.47E-05 6.21633E-04 0
R/H 7556 Ig-60 42 rs374344734 0.1804 -0.799 0.99 N 0.347 0.23 None gnomAD-4.0.0 6.50793E-05 None None None None N None 3.07117E-04 1.66717E-05 None 0 0 None 0 1.64636E-04 1.78027E-05 6.25961E-04 3.20318E-05
R/L 7556 Ig-60 42 rs374344734 0.4821 0.361 0.308 N 0.354 0.277 0.412064437402 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 4.64E-05 0 0
R/L 7556 Ig-60 42 rs374344734 0.4821 0.361 0.308 N 0.354 0.277 0.412064437402 gnomAD-4.0.0 1.36865E-06 None None None None N None 0 0 None 0 0 None 3.74546E-05 0 0 0 0
R/S 7556 Ig-60 42 rs754885396 0.8531 -0.172 0.722 N 0.387 0.273 0.33110744837 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
R/S 7556 Ig-60 42 rs754885396 0.8531 -0.172 0.722 N 0.387 0.273 0.33110744837 gnomAD-4.0.0 2.05299E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69886E-06 0 0
H/L 7650 Ig-61 43 rs144326093 0.0827 0.878 0.101 N 0.303 0.275 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
H/L 7650 Ig-61 43 rs144326093 0.0827 0.878 0.101 N 0.303 0.275 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
H/L 7650 Ig-61 43 rs144326093 0.0827 0.878 0.101 N 0.303 0.275 None gnomAD-4.0.0 6.56607E-06 None None None None N None 2.40512E-05 0 None 0 0 None 0 0 0 0 0
H/N 7650 Ig-61 43 rs868182073 0.0906 None 0.183 N 0.189 0.194 0.225902525712 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
H/N 7650 Ig-61 43 rs868182073 0.0906 None 0.183 N 0.189 0.194 0.225902525712 gnomAD-4.0.0 2.02992E-06 None None None None N None 0 0 None 0 0 None 0 0 2.40987E-06 0 0
H/Q 7650 Ig-61 43 None 0.0815 None 0.003 N 0.178 0.086 0.126345400529 gnomAD-4.0.0 6.84466E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99805E-07 0 0
H/R 7650 Ig-61 43 rs144326093 0.0606 -0.106 0.101 N 0.173 0.15 0.208000267992 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
H/R 7650 Ig-61 43 rs144326093 0.0606 -0.106 0.101 N 0.173 0.15 0.208000267992 gnomAD-4.0.0 3.18526E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72312E-06 0 0
R/G 7837 Ig-63 43 None 0.347 None 0.978 N 0.503 0.399 0.318828661733 gnomAD-4.0.0 3.18281E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85868E-06 0 3.02444E-05
S/F 7930 Ig-64 42 None 0.1064 None 0.029 N 0.454 0.267 0.508163421412 gnomAD-4.0.0 1.59141E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
S/P 7930 Ig-64 42 rs2078046090 0.0934 None 0.055 N 0.366 0.218 0.115124310173 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/P 7930 Ig-64 42 rs2078046090 0.0934 None 0.055 N 0.366 0.218 0.115124310173 gnomAD-4.0.0 6.5735E-06 None None None None N None 2.41406E-05 0 None 0 0 None 0 0 0 0 0
V/D 8026 Ig-65 42 None 0.1506 None 0.055 N 0.411 0.207 0.650414729863 gnomAD-4.0.0 1.3684E-06 None None None None N None 0 0 None 0 2.51915E-05 None 0 0 0 1.15931E-05 0
V/G 8026 Ig-65 42 None 0.1076 None 0.055 N 0.415 0.205 0.667366933581 gnomAD-4.0.0 6.84201E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99478E-07 0 0
V/A 8119 Ig-66 42 rs758744997 0.1259 -0.387 0.101 N 0.221 0.241 0.372446077551 gnomAD-2.1.1 2.14E-05 None None None None N None 0 1.69847E-04 None 0 0 None 0 None 0 0 0
V/A 8119 Ig-66 42 rs758744997 0.1259 -0.387 0.101 N 0.221 0.241 0.372446077551 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
V/A 8119 Ig-66 42 rs758744997 0.1259 -0.387 0.101 N 0.221 0.241 0.372446077551 gnomAD-4.0.0 8.96893E-06 None None None None N None 0 1.18648E-04 None 0 0 None 0 0 0 0 0
V/G 8119 Ig-66 42 None 0.1301 None 0.351 N 0.401 0.255 0.59966951432 gnomAD-4.0.0 1.59136E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
V/M 8119 Ig-66 42 rs1232702196 0.1114 -0.477 0.047 N 0.163 0.23 0.336892272479 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
V/M 8119 Ig-66 42 rs1232702196 0.1114 -0.477 0.047 N 0.163 0.23 0.336892272479 gnomAD-4.0.0 1.59136E-06 None None None None N None 0 2.28655E-05 None 0 0 None 0 0 0 0 0
R/Q 8305 Ig-68 42 rs759985618 0.3994 0.091 0.948 N 0.335 0.267 0.247322355667 gnomAD-2.1.1 5.23E-05 None None None None N None 0 2.89788E-04 None 0 5.57E-05 None 0 None 0 1.78E-05 0
R/Q 8305 Ig-68 42 rs759985618 0.3994 0.091 0.948 N 0.335 0.267 0.247322355667 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/Q 8305 Ig-68 42 rs759985618 0.3994 0.091 0.948 N 0.335 0.267 0.247322355667 gnomAD-4.0.0 3.34745E-05 None None None None N None 0 2.33403E-04 None 0 2.22846E-05 None 0 0 3.05163E-05 0 4.80369E-05
R/C 8497 Ig-70 42 rs369517119 0.5592 -0.337 1.0 N 0.345 0.441 None gnomAD-2.1.1 3.21E-05 None None None None N None 6.46E-05 2.9E-05 None 0 0 None 3.27E-05 None 0 4.43E-05 0
R/C 8497 Ig-70 42 rs369517119 0.5592 -0.337 1.0 N 0.345 0.441 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92827E-04 None 0 0 0 0 0
R/C 8497 Ig-70 42 rs369517119 0.5592 -0.337 1.0 N 0.345 0.441 None gnomAD-4.0.0 1.11553E-05 None None None None N None 1.33486E-05 1.667E-05 None 0 2.22846E-05 None 3.1248E-05 0 1.01722E-05 1.09794E-05 0
R/H 8497 Ig-70 42 rs149855485 0.2535 -0.757 0.99 N 0.374 0.192 None gnomAD-2.1.1 3.44631E-03 None None None None N None 1.23977E-04 7.6392E-04 None 1.06321E-03 1.02543E-04 None 2.18613E-02 None 4E-05 1.8021E-03 3.08989E-03
R/H 8497 Ig-70 42 rs149855485 0.2535 -0.757 0.99 N 0.374 0.192 None gnomAD-3.1.2 1.76827E-03 None None None None N None 1.68943E-04 1.70291E-03 0 8.64055E-04 1.92604E-04 None 0 0 1.67637E-03 2.3849E-02 1.43541E-03
R/H 8497 Ig-70 42 rs149855485 0.2535 -0.757 0.99 N 0.374 0.192 None 1000 genomes 5.99042E-03 None None None None N None 0 1.4E-03 None None 0 2E-03 None None None 2.76E-02 None
R/H 8497 Ig-70 42 rs149855485 0.2535 -0.757 0.99 N 0.374 0.192 None gnomAD-4.0.0 2.20866E-03 None None None None N None 2.5332E-04 9.49937E-04 None 8.44709E-04 8.91504E-05 None 6.2498E-05 4.12405E-03 1.12914E-03 2.12259E-02 2.64135E-03
R/S 8497 Ig-70 42 rs369517119 0.9095 None 0.881 N 0.385 0.235 0.373357554552 gnomAD-4.0.0 6.84274E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99546E-07 0 0
R/M 8684 Ig-72 42 rs1185236077 0.378 -0.194 0.054 N 0.199 0.187 0.304435445954 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
R/M 8684 Ig-72 42 rs1185236077 0.378 -0.194 0.054 N 0.199 0.187 0.304435445954 gnomAD-4.0.0 1.36848E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79904E-06 0 0
R/K 8778 Ig-73 43 rs1486145907 0.1276 None 0.972 N 0.56 0.297 0.315609569513 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 2.07039E-04 0
R/K 8778 Ig-73 43 rs1486145907 0.1276 None 0.972 N 0.56 0.297 0.315609569513 gnomAD-4.0.0 8.05664E-06 None None None None N None 0 0 None 0 0 None 0 0 9.32417E-06 2.19582E-05 0
R/S 8778 Ig-73 43 rs754011566 0.4619 -0.04 1.0 D 0.651 0.388 0.380730819819 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
R/T 8778 Ig-73 43 rs1486145907 0.24 0.116 1.0 N 0.645 0.39 0.646531519106 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/T 8778 Ig-73 43 rs1486145907 0.24 0.116 1.0 N 0.645 0.39 0.646531519106 gnomAD-4.0.0 6.84268E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9952E-07 0 0
T/A 8871 Ig-74 42 rs2077092454 0.0688 None None N 0.117 0.1 0.126345400529 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
T/A 8871 Ig-74 42 rs2077092454 0.0688 None None N 0.117 0.1 0.126345400529 gnomAD-4.0.0 6.57272E-06 None None None None N None 0 6.54965E-05 None 0 0 None 0 0 0 0 0
S/C 8967 Ig-75 42 rs1046768266 0.0971 None 0.936 N 0.371 0.294 0.481468437379 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
S/C 8967 Ig-75 42 rs1046768266 0.0971 None 0.936 N 0.371 0.294 0.481468437379 gnomAD-4.0.0 3.84552E-06 None None None None N None 5.07563E-05 0 None 0 0 None 0 0 0 0 0
S/N 8967 Ig-75 42 None 0.0999 None 0.351 N 0.229 0.067 0.180583059064 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/T 8967 Ig-75 42 rs1399004150 0.0652 0.055 0.001 N 0.139 0.062 0.15556083564 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
V/I 9060 Ig-76 42 None 0.0745 None None D 0.169 0.111 0.391775403332 gnomAD-4.0.0 3.18274E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8583E-06 1.43287E-05 0
R/I 9246 Ig-78 42 rs1404441295 0.4618 None 0.998 N 0.638 0.445 0.755339858868 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/I 9246 Ig-78 42 rs1404441295 0.4618 None 0.998 N 0.638 0.445 0.755339858868 gnomAD-4.0.0 3.84354E-06 None None None None N None 0 0 None 0 0 None 0 0 7.17892E-06 0 0
R/K 9246 Ig-78 42 rs1404441295 0.1904 0.255 0.998 N 0.505 0.211 0.348983352498 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
R/K 9246 Ig-78 42 rs1404441295 0.1904 0.255 0.998 N 0.505 0.211 0.348983352498 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.45E-05 0 0 0 0
R/K 9246 Ig-78 42 rs1404441295 0.1904 0.255 0.998 N 0.505 0.211 0.348983352498 gnomAD-4.0.0 2.56236E-06 None None None None N None 0 0 None 0 0 None 1.56996E-05 0 2.39297E-06 0 0
R/S 9246 Ig-78 42 None 0.7859 None 0.994 N 0.508 0.328 0.322510055762 gnomAD-4.0.0 1.59125E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85827E-06 0 0
R/Q 9438 Ig-80 42 rs72648998 0.1409 0.056 0.175 None 0.253 0.105 None gnomAD-2.1.1 4.68935E-02 None None None None N None 1E-02 9.45915E-02 None 5.35059E-02 5.12E-05 None 3.55859E-02 None 1.95875E-02 5.53338E-02 4.67787E-02
R/Q 9438 Ig-80 42 rs72648998 0.1409 0.056 0.175 None 0.253 0.105 None gnomAD-3.1.2 4.08323E-02 None None None None N None 1.22858E-02 6.09037E-02 1.41447E-01 4.95392E-02 3.85802E-04 None 2.45283E-02 1.89873E-02 5.81922E-02 3.63071E-02 3.34928E-02
R/Q 9438 Ig-80 42 rs72648998 0.1409 0.056 0.175 None 0.253 0.105 None 1000 genomes 2.73562E-02 None None None None N None 0 8.07E-02 None None 0 5.47E-02 None None None 2.66E-02 None
R/Q 9438 Ig-80 42 rs72648998 0.1409 0.056 0.175 None 0.253 0.105 None gnomAD-4.0.0 5.42117E-02 None None None None N None 1.0836E-02 8.35278E-02 None 5.20165E-02 2.67439E-04 None 2.11243E-02 3.10333E-02 6.08438E-02 3.76515E-02 5.16916E-02
Q/K 9535 Ig-81 43 rs778021049 0.0756 0.221 0.003 None 0.161 0.099 0.163833314356 gnomAD-2.1.1 1.2E-05 None None None None I None 0 0 None 0 1.66908E-04 None 0 None 0 0 0
Q/K 9535 Ig-81 43 rs778021049 0.0756 0.221 0.003 None 0.161 0.099 0.163833314356 gnomAD-4.0.0 2.73669E-06 None None None None I None 0 0 None 0 7.55744E-05 None 0 0 8.99442E-07 0 0
N/K 9740 Ig-83 43 rs371745586 0.763 0.556 0.961 None 0.521 0.253 0.267299060538 gnomAD-2.1.1 4.01E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.85E-06 0
N/K 9740 Ig-83 43 rs371745586 0.763 0.556 0.961 None 0.521 0.253 0.267299060538 gnomAD-3.1.2 1.31E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
N/K 9740 Ig-83 43 rs371745586 0.763 0.556 0.961 None 0.521 0.253 0.267299060538 gnomAD-4.0.0 2.05252E-06 None None None None I None 0 0 None 0 0 None 0 0 2.6983E-06 0 0
N/S 9740 Ig-83 43 rs753121692 0.1596 0.325 0.835 None 0.587 0.207 None gnomAD-2.1.1 3.92E-05 None None None None I None 8.27E-05 2.83E-05 None 9.66E-05 0 None 0 None 0 5.45E-05 0
N/S 9740 Ig-83 43 rs753121692 0.1596 0.325 0.835 None 0.587 0.207 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
N/S 9740 Ig-83 43 rs753121692 0.1596 0.325 0.835 None 0.587 0.207 None gnomAD-4.0.0 6.07259E-05 None None None None I None 1.3344E-05 1.66689E-05 None 0 0 None 0 0 7.96722E-05 0 3.20174E-05
N/T 9740 Ig-83 43 None 0.3284 None 0.122 None 0.227 0.175 0.272205846399 gnomAD-4.0.0 6.84175E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99437E-07 0 0
E/D 9942 Ig-84 43 None 0.1295 None 0.002 None 0.131 0.051 0.144782658237 gnomAD-4.0.0 1.59497E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4367E-05 0
K/Q 10029 Ig-85 41 None 0.189 None 0.045 None 0.182 0.142 0.206339911435 gnomAD-4.0.0 1.36827E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31863E-05 0
T/K 10118 Ig-86 41 None 0.2393 None None None 0.083 0.144 0.0482279557977 gnomAD-4.0.0 1.59085E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85745E-06 0 0
R/C 13727 Ig-87 44 rs397517563 0.6863 -0.017 1.0 D 0.702 0.508 0.721734935014 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/C 13727 Ig-87 44 rs397517563 0.6863 -0.017 1.0 D 0.702 0.508 0.721734935014 gnomAD-3.1.2 1.32E-05 None None None None N None 2.41E-05 0 0 0 1.93949E-04 None 0 0 0 0 0
R/C 13727 Ig-87 44 rs397517563 0.6863 -0.017 1.0 D 0.702 0.508 0.721734935014 gnomAD-4.0.0 5.12692E-06 None None None None N None 1.69205E-05 0 None 0 2.43002E-05 None 0 0 2.39419E-06 1.3402E-05 0
R/H 13727 Ig-87 44 rs750520224 0.3184 -0.773 1.0 N 0.729 0.452 0.416328079214 gnomAD-2.1.1 2.82E-05 None None None None N None 0 1.15955E-04 None 0 0 None 0 None 0 1.78E-05 1.65948E-04
R/H 13727 Ig-87 44 rs750520224 0.3184 -0.773 1.0 N 0.729 0.452 0.416328079214 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/H 13727 Ig-87 44 rs750520224 0.3184 -0.773 1.0 N 0.729 0.452 0.416328079214 gnomAD-4.0.0 1.4876E-05 None None None None N None 0 8.33945E-05 None 0 0 None 0 0 1.27164E-05 0 6.40677E-05
V/A 13820 Ig-88 41 rs373963620 0.2095 -0.489 0.183 N 0.243 0.073 None gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
V/M 13820 Ig-88 41 rs376127282 0.1855 -0.51 0.655 N 0.361 0.072 None gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
V/M 13820 Ig-88 41 rs376127282 0.1855 -0.51 0.655 N 0.361 0.072 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/M 13820 Ig-88 41 rs376127282 0.1855 -0.51 0.655 N 0.361 0.072 None gnomAD-4.0.0 6.41055E-06 None None None None N None 0 0 None 0 0 None 0 0 1.19733E-05 0 0
P/S 13914 Ig-89 39 rs755785975 0.2331 -0.184 0.92 N 0.371 0.218 0.167679373172 gnomAD-2.1.1 1.2E-05 None None None None N None 0 0 None 0 5.79E-05 None 0 None 0 1.8E-05 0
P/S 13914 Ig-89 39 rs755785975 0.2331 -0.184 0.92 N 0.371 0.218 0.167679373172 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/S 13914 Ig-89 39 rs755785975 0.2331 -0.184 0.92 N 0.371 0.218 0.167679373172 gnomAD-4.0.0 1.25469E-06 None None None None N None 0 0 None 0 0 None 0 0 1.71072E-06 0 0
R/S 14005 Ig-90 41 None 0.8845 None 0.524 N 0.515 0.137 0.110078149338 gnomAD-4.0.0 1.59332E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43579E-05 0
K/N 14093 Ig-91 40 rs2060181153 0.5328 None 0.98 N 0.516 0.28 0.213573922156 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/N 14093 Ig-91 40 rs2060181153 0.5328 None 0.98 N 0.516 0.28 0.213573922156 gnomAD-4.0.0 6.84398E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99648E-07 0 0
K/R 14093 Ig-91 40 rs1553743733 0.1065 None 0.98 N 0.536 0.242 0.315903272564 gnomAD-4.0.0 1.5922E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86005E-06 0 0
H/P 14182 Ig-92 41 rs794729428 0.2405 None 0.999 N 0.564 0.472 0.573614764001 gnomAD-4.0.0 2.05301E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69886E-06 0 0
V/F 14270 Ig-93 40 rs1187293520 0.117 -0.627 0.093 N 0.417 0.038 0.405012372841 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
V/F 14270 Ig-93 40 rs1187293520 0.117 -0.627 0.093 N 0.417 0.038 0.405012372841 gnomAD-4.0.0 1.36875E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31879E-05 0
V/I 14270 Ig-93 40 None 0.0657 None None N 0.172 0.058 0.259761712551 gnomAD-4.0.0 6.84376E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9959E-07 0 0
T/A 14359 Ig-94 41 rs1472230536 0.0954 None 0.451 N 0.545 0.127 0.0762999501168 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
T/A 14359 Ig-94 41 rs1472230536 0.0954 None 0.451 N 0.545 0.127 0.0762999501168 gnomAD-4.0.0 9.5637E-06 None None None None N None 0 0 None 0 0 None 1.88423E-05 0 1.14488E-05 0 3.02939E-05
T/I 14359 Ig-94 41 rs779102939 0.1345 None 0.966 N 0.452 0.269 0.239305524855 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
T/I 14359 Ig-94 41 rs779102939 0.1345 None 0.966 N 0.452 0.269 0.239305524855 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 14359 Ig-94 41 rs779102939 0.1345 None 0.966 N 0.452 0.269 0.239305524855 gnomAD-4.0.0 1.17837E-05 None None None None N None 1.33583E-05 0 None 0 0 None 0 0 1.4417E-05 0 1.60313E-05
T/R 14359 Ig-94 41 None 0.1708 None 0.933 N 0.465 0.28 0.322786055943 gnomAD-4.0.0 1.36958E-06 None None None None N None 2.99276E-05 0 None 0 0 None 0 0 8.99962E-07 0 0
T/A 14448 Ig-95 41 rs773346487 0.0698 -0.075 None N 0.096 0.115 0.0551355673512 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
T/A 14448 Ig-95 41 rs773346487 0.0698 -0.075 None N 0.096 0.115 0.0551355673512 gnomAD-4.0.0 1.59188E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85971E-06 0 0
T/I 14448 Ig-95 41 rs545318911 0.102 0.123 None N 0.206 0.159 0.231873229951 gnomAD-2.1.1 2.02E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.48E-05 0
T/I 14448 Ig-95 41 rs545318911 0.102 0.123 None N 0.206 0.159 0.231873229951 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07383E-04 0
T/I 14448 Ig-95 41 rs545318911 0.102 0.123 None N 0.206 0.159 0.231873229951 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
T/I 14448 Ig-95 41 rs545318911 0.102 0.123 None N 0.206 0.159 0.231873229951 gnomAD-4.0.0 6.40782E-06 None None None None N None 0 0 None 0 0 None 0 0 7.18312E-06 2.68068E-05 0
T/R 14448 Ig-95 41 rs545318911 0.1079 0.247 0.017 N 0.383 0.109 0.333906830038 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
T/R 14448 Ig-95 41 rs545318911 0.1079 0.247 0.017 N 0.383 0.109 0.333906830038 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/R 14448 Ig-95 41 rs545318911 0.1079 0.247 0.017 N 0.383 0.109 0.333906830038 gnomAD-4.0.0 6.57869E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47102E-05 0 0
H/Q 14537 Ig-96 41 None 0.3815 None 1.0 N 0.671 0.323 0.314716216878 gnomAD-4.0.0 6.85972E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00847E-07 0 0
K/R 14626 Ig-97 41 rs2059753756 0.0961 None 0.029 N 0.327 0.098 0.362758974969 gnomAD-4.0.0 6.00161E-06 None None None None N None 0 0 None 0 0 None 0 0 6.56251E-06 0 0
K/T 14626 Ig-97 41 None 0.0709 None None N 0.131 0.135 0.273503213844 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/F 14715 Ig-98 41 rs1448072807 0.1005 None 0.468 N 0.337 0.183 0.265010934533 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
L/F 14715 Ig-98 41 rs1448072807 0.1005 None 0.468 N 0.337 0.183 0.265010934533 gnomAD-4.0.0 2.56581E-06 None None None None N None 3.38753E-05 0 None 0 0 None 0 0 0 0 0
L/I 14715 Ig-98 41 rs1448072807 0.0903 0.048 0.201 N 0.43 0.127 0.209622950755 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
L/I 14715 Ig-98 41 rs1448072807 0.0903 0.048 0.201 N 0.43 0.127 0.209622950755 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
L/I 14715 Ig-98 41 rs1448072807 0.0903 0.048 0.201 N 0.43 0.127 0.209622950755 gnomAD-4.0.0 6.57514E-06 None None None None N None 2.41406E-05 0 None 0 0 None 0 0 0 0 0
L/P 14715 Ig-98 41 None 0.1969 None 0.641 N 0.592 0.171 0.436671004673 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
E/V 14804 Ig-99 40 None 0.122 None 1.0 N 0.694 0.492 0.688307381067 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/F 14893 Ig-100 41 None 0.1313 None 0.003 N 0.187 0.143 0.461323234107 gnomAD-4.0.0 1.59357E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86239E-06 0 0
L/P 14893 Ig-100 41 None 0.1544 None 0.954 N 0.395 0.299 0.778704876926 gnomAD-4.0.0 3.42315E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49937E-06 0 0
K/R 14982 Ig-101 41 None 0.0864 None 0.002 N 0.163 0.156 0.238705975628 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
I/T 15071 Ig-102 41 rs184078045 0.0753 -0.645 0.425 N 0.349 0.286 None gnomAD-2.1.1 6.81E-05 None None None None N None 4.14E-05 2.84E-05 None 0 8.79371E-04 None 0 None 0 0 0
I/T 15071 Ig-102 41 rs184078045 0.0753 -0.645 0.425 N 0.349 0.286 None gnomAD-3.1.2 6.59E-05 None None None None N None 7.25E-05 0 0 0 1.17233E-03 None 0 0 1.47E-05 0 0
I/T 15071 Ig-102 41 rs184078045 0.0753 -0.645 0.425 N 0.349 0.286 None 1000 genomes 7.98722E-04 None None None None N None 0 0 None None 4E-03 0 None None None 0 None
I/T 15071 Ig-102 41 rs184078045 0.0753 -0.645 0.425 N 0.349 0.286 None gnomAD-4.0.0 2.54265E-05 None None None None N None 5.33988E-05 3.34146E-05 None 0 5.59635E-04 None 1.56274E-05 0 5.08863E-06 1.09832E-05 3.20492E-05
I/V 15071 Ig-102 41 rs1441511907 0.0825 -0.237 0.396 N 0.189 0.163 0.486636631601 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
I/V 15071 Ig-102 41 rs1441511907 0.0825 -0.237 0.396 N 0.189 0.163 0.486636631601 gnomAD-4.0.0 6.37462E-06 None None None None N None 0 0 None 0 0 None 0 0 8.58802E-06 0 3.0303E-05
E/K 15160 Ig-103 41 None 0.1543 0.831 0.956 N 0.584 0.277 0.392855499163 gnomAD-4.0.0 1.59424E-06 None None None None N None 0 0 None 0 0 None 1.88466E-05 0 0 0 0
F/I 15248 Ig-104 41 None 0.3012 None 0.971 N 0.539 0.441 0.454426139905 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
F/L 15248 Ig-104 41 None 0.8724 None 0.822 N 0.547 0.343 0.409937222855 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/H 15342 Ig-105 41 rs2154211069 0.1634 None 0.828 N 0.393 0.187 0.411265580357 gnomAD-4.0.0 1.59417E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86372E-06 0 0
V/F 15520 Ig-107 41 rs2057990397 0.2591 None 0.993 N 0.681 0.245 0.775140819604 gnomAD-4.0.0 1.59391E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43377E-05 0
S/C 15609 Ig-108 42 rs2057780227 0.1084 None 0.975 N 0.371 0.367 0.475430695062 gnomAD-4.0.0 1.59519E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86453E-06 0 0
S/P 15609 Ig-108 42 None 0.0532 None None N 0.167 0.137 0.110078149338 gnomAD-4.0.0 1.59522E-06 None None None None N None 0 0 None 4.78057E-05 0 None 0 0 0 0 0
D/N 17714 Ig-113 38 None 0.1138 None 0.046 N 0.305 0.189 0.216624796971 gnomAD-4.0.0 6.84404E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15953E-05 0
D/Y 17714 Ig-113 38 rs1051253179 0.2227 0.225 0.999 N 0.666 0.43 0.748738615344 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
D/Y 17714 Ig-113 38 rs1051253179 0.2227 0.225 0.999 N 0.666 0.43 0.748738615344 gnomAD-4.0.0 1.23193E-05 None None None None N None 0 0 None 0 0 None 0 0 1.61948E-05 0 0
E/G 18008 Ig-114 41 None 0.089 None 0.22 N 0.539 0.122 0.227934060464 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
E/K 18008 Ig-114 41 rs2054482853 0.1273 None 0.22 N 0.525 0.191 0.203808441222 gnomAD-4.0.0 3.18777E-06 None None None None N None 0 0 None 9.54563E-05 0 None 0 0 0 0 0
K/E 18420 Ig-115 39 None 0.2623 None 0.801 N 0.481 0.205 0.403328974453 gnomAD-4.0.0 4.10753E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39916E-06 0 0
P/A 18726 Ig-116 39 rs747026598 0.0643 0.088 0.998 N 0.553 0.283 0.417334834585 gnomAD-3.1.2 1.32E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
P/A 18726 Ig-116 39 rs747026598 0.0643 0.088 0.998 N 0.553 0.283 0.417334834585 gnomAD-4.0.0 3.04536E-06 None None None None N None 1.74819E-05 0 None 0 0 None 0 0 2.41002E-06 0 0
P/L 18726 Ig-116 39 rs1181651435 0.099 None 0.64 N 0.557 0.387 0.551757199483 gnomAD-3.1.2 1.32E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
P/L 18726 Ig-116 39 rs1181651435 0.099 None 0.64 N 0.557 0.387 0.551757199483 gnomAD-4.0.0 3.84754E-06 None None None None N None 1.69331E-05 0 None 0 0 None 1.56902E-05 0 2.3957E-06 0 0
P/S 19828 Ig-119 39 None 0.1532 None 0.362 N 0.308 0.24 None gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 20518 Ig-121 40 rs1223901169 0.0787 -0.04 0.029 N 0.267 0.067 0.261217442401 gnomAD-2.1.1 8.09E-06 None None None None N None 0 0 None 0 1.11957E-04 None 0 None 0 0 0
V/I 20518 Ig-121 40 rs1223901169 0.0787 -0.04 0.029 N 0.267 0.067 0.261217442401 gnomAD-4.0.0 4.78536E-06 None None None None N None 0 0 None 0 8.33472E-05 None 0 0 0 0 0
V/M 21216 Ig-123 40 rs542681131 0.3359 -0.362 1.0 N 0.619 0.293 0.512595481341 gnomAD-2.1.1 2.82E-05 None None None None I None 0 0 None 0 0 None 2.28938E-04 None 0 0 0
V/M 21216 Ig-123 40 rs542681131 0.3359 -0.362 1.0 N 0.619 0.293 0.512595481341 gnomAD-3.1.2 3.29E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 8.28157E-04 0
V/M 21216 Ig-123 40 rs542681131 0.3359 -0.362 1.0 N 0.619 0.293 0.512595481341 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
V/M 21216 Ig-123 40 rs542681131 0.3359 -0.362 1.0 N 0.619 0.293 0.512595481341 gnomAD-4.0.0 1.98398E-05 None None None None I None 1.33397E-05 0 None 0 0 None 0 0 0 3.29504E-04 1.60159E-05
V/F 21508 Ig-124 40 None 0.1101 None 0.317 N 0.373 0.127 0.721282347704 gnomAD-4.0.0 2.73761E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59888E-06 0 0
V/I 21508 Ig-124 40 rs759982511 0.0663 -0.108 None N 0.225 0.115 0.460703734027 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 1.30745E-04 None 0 0 0
V/I 21508 Ig-124 40 rs759982511 0.0663 -0.108 None N 0.225 0.115 0.460703734027 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 21508 Ig-124 40 rs759982511 0.0663 -0.108 None N 0.225 0.115 0.460703734027 gnomAD-4.0.0 3.90521E-05 None None None None I None 0 0 None 0 0 None 0 0 4.57839E-05 7.68791E-05 3.20328E-05
K/N 21905 Ig-125 40 rs574615636 0.3266 0.28 0.351 N 0.364 0.109 0.158396225186 gnomAD-2.1.1 1.64E-05 None None None None N None 0 0 None 0 0 None 1.31848E-04 None 0 0 0
K/N 21905 Ig-125 40 rs574615636 0.3266 0.28 0.351 N 0.364 0.109 0.158396225186 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
K/N 21905 Ig-125 40 rs574615636 0.3266 0.28 0.351 N 0.364 0.109 0.158396225186 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
K/N 21905 Ig-125 40 rs574615636 0.3266 0.28 0.351 N 0.364 0.109 0.158396225186 gnomAD-4.0.0 5.58497E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69695E-06 7.70365E-05 0
K/Q 21905 Ig-125 40 None 0.1063 None 0.007 N 0.22 0.15 0.149567049428 gnomAD-4.0.0 1.59674E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86705E-06 0 0
R/K 22989 Ig-128 40 None 0.0761 None 0.002 N 0.233 0.134 0.197625483188 gnomAD-4.0.0 6.84373E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99599E-07 0 0
R/S 22989 Ig-128 40 rs1295839847 0.3293 None 0.801 N 0.516 0.257 0.266843984389 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
R/S 22989 Ig-128 40 rs1295839847 0.3293 None 0.801 N 0.516 0.257 0.266843984389 gnomAD-4.0.0 1.59214E-06 None None None None N None 0 0 None 0 2.77932E-05 None 0 0 0 0 0
R/T 22989 Ig-128 40 None 0.1601 None 0.801 N 0.518 0.263 0.529763130185 gnomAD-4.0.0 1.36875E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7992E-06 0 0
K/N 23675 Ig-130 39 None 0.7728 None 0.978 N 0.637 0.286 0.27132560031 gnomAD-4.0.0 1.59279E-06 None None None None N None 0 0 None 0 2.78816E-05 None 0 0 0 0 0
K/R 24757 Ig-133 42 None 0.0785 None 0.001 N 0.28 0.107 0.199424873507 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/Q 25839 Ig-136 42 rs1371831965 0.2318 None 0.993 N 0.631 0.384 0.358948522604 gnomAD-4.0.0 6.8435E-06 None None None None N None 2.98972E-05 0 None 0 0 None 0 0 8.09666E-06 0 0
K/R 25839 Ig-136 42 None 0.0842 None 0.235 N 0.339 0.143 0.396044805602 gnomAD-4.0.0 2.05306E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99632E-07 0 3.31411E-05
K/R 28004 Ig-142 42 rs776987640 0.0694 0.204 0.001 D 0.253 0.084 0.255777322467 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.99E-06 0
K/R 28004 Ig-142 42 rs776987640 0.0694 0.204 0.001 D 0.253 0.084 0.255777322467 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/R 28004 Ig-142 42 rs776987640 0.0694 0.204 0.001 D 0.253 0.084 0.255777322467 gnomAD-4.0.0 6.57056E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46985E-05 0 0
K/E 29086 Ig-145 42 None 0.4517 None 0.928 N 0.581 0.396 0.36036328697 gnomAD-4.0.0 1.59103E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85781E-06 0 0
E/K 30568 Ig-149 37 rs567700310 0.1419 0.432 0.958 N 0.375 0.261 0.319114376414 gnomAD-2.1.1 5.63E-05 None None None None N None 0 2.31736E-04 None 0 0 None 1.30719E-04 None 0 1.78E-05 0
E/K 30568 Ig-149 37 rs567700310 0.1419 0.432 0.958 N 0.375 0.261 0.319114376414 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/K 30568 Ig-149 37 rs567700310 0.1419 0.432 0.958 N 0.375 0.261 0.319114376414 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
E/K 30568 Ig-149 37 rs567700310 0.1419 0.432 0.958 N 0.375 0.261 0.319114376414 gnomAD-4.0.0 2.16891E-05 None None None None N None 0 1.16667E-04 None 0 0 None 0 0 2.03433E-05 4.39252E-05 0
S/G 32746 Ig-155 39 rs1414547750 0.1213 -0.122 0.99 N 0.469 0.165 0.257786959452 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
S/N 32746 Ig-155 39 rs1410694267 0.2128 0.086 0.997 N 0.495 0.235 0.243398259712 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
S/N 32746 Ig-155 39 rs1410694267 0.2128 0.086 0.997 N 0.495 0.235 0.243398259712 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
S/N 32746 Ig-155 39 rs1410694267 0.2128 0.086 0.997 N 0.495 0.235 0.243398259712 gnomAD-4.0.0 1.30131E-05 None None None None N None 1.33461E-05 0 None 0 0 None 0 0 1.52568E-05 2.19578E-05 0
I/T 33142 Ig-156 42 rs1338367198 0.1053 None 0.01 N 0.367 0.136 0.601870671465 gnomAD-4.0.0 1.59137E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
I/F 33537 Ig-158 42 rs1184341890 0.1332 None 0.523 N 0.235 0.176 0.436025050644 gnomAD-4.0.0 4.77468E-06 None None None None I None 0 0 None 0 0 None 0 0 8.57604E-06 0 0
D/E 33637 Ig-159 42 None 0.6418 None 0.966 N 0.39 0.149 0.251639045875 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
D/N 33637 Ig-159 42 None 0.5127 None 0.991 N 0.486 0.212 0.284150004643 gnomAD-4.0.0 2.05269E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69843E-06 0 0
E/Q 34178 Ig-160 42 rs774700628 0.1736 0.331 0.99 N 0.468 0.193 0.281780670237 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
E/Q 34178 Ig-160 42 rs774700628 0.1736 0.331 0.99 N 0.468 0.193 0.281780670237 gnomAD-4.0.0 2.73664E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59766E-06 0 0
K/M 35327 Ig-165 42 rs1164792965 0.2678 -0.29 1.0 N 0.5 0.556 0.407901774203 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/M 35327 Ig-165 42 rs1164792965 0.2678 -0.29 1.0 N 0.5 0.556 0.407901774203 gnomAD-4.0.0 1.59088E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
T/A 35461 Ig-166 42 rs1452738777 0.0834 -0.335 None N 0.106 0.147 0.0846915920261 gnomAD-2.1.1 4.35E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.79533E-04
T/A 35461 Ig-166 42 rs1452738777 0.0834 -0.335 None N 0.106 0.147 0.0846915920261 gnomAD-4.0.0 1.6385E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.08814E-05
T/I 35461 Ig-166 42 rs773250184 0.0893 -0.003 None N 0.187 0.075 0.198526703765 gnomAD-2.1.1 8.7E-06 None None None None N None 0 0 None 0 0 None 3.86E-05 None 0 9.28E-06 0
T/I 35461 Ig-166 42 rs773250184 0.0893 -0.003 None N 0.187 0.075 0.198526703765 gnomAD-4.0.0 3.27724E-06 None None None None N None 0 0 None 0 0 None 0 0 2.89369E-06 1.53638E-05 0
T/A 35646 Ig-167 40 rs1558970634 0.0758 None None N 0.11 0.109 0.0666544352282 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
T/A 35646 Ig-167 40 rs1558970634 0.0758 None None N 0.11 0.109 0.0666544352282 gnomAD-4.0.0 1.59133E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8583E-06 0 0
S/Y 35743 Ig-168 42 None 0.2254 None 0.966 N 0.407 0.268 0.711965941606 gnomAD-4.0.0 1.5944E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.44454E-05 0
H/R 35938 Ig-169 42 rs1233232821 0.0625 -0.379 0.001 N 0.171 0.085 0.16115917748 gnomAD-2.1.1 4.01E-06 None None None -1.157(OBSL1) -1.572(OBSCN) N None 0 0 None 0 0 None 0 None 0 8.85E-06 0
H/R 35938 Ig-169 42 rs1233232821 0.0625 -0.379 0.001 N 0.171 0.085 0.16115917748 gnomAD-4.0.0 1.59089E-06 None None None -1.157(OBSL1) -1.572(OBSCN) N None 0 0 None 0 0 None 0 0 2.85752E-06 0 0
H/Y 35938 Ig-169 42 None 0.0843 None 0.013 N 0.249 0.084 0.235664433957 gnomAD-4.0.0 1.59091E-06 None None None -0.042(OBSL1) -0.181(OBSCN) N None 0 0 None 0 0 None 0 0 2.85755E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.