Structural position:

  • Domain Type: Fn3
  • Aligned Position: 105
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand F

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
L/I 15729 Fn3-1 73 None 0.1171 None 0.999 N 0.543 0.21 0.343334270461 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/P 15729 Fn3-1 73 rs1364835059 0.9878 None 1.0 D 0.747 0.651 0.767801976584 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/P 15729 Fn3-1 73 rs1364835059 0.9878 None 1.0 D 0.747 0.651 0.767801976584 gnomAD-4.0.0 6.58137E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47262E-05 0 0
L/S 16126 Fn3-4 72 rs764312225 0.3868 -2.565 0.638 N 0.685 0.403 0.785186314975 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
L/S 16126 Fn3-4 72 rs764312225 0.3868 -2.565 0.638 N 0.685 0.403 0.785186314975 gnomAD-4.0.0 3.18862E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72908E-06 0 0
A/G 16226 Fn3-5 72 None 0.1655 None 0.41 N 0.623 0.219 0.489658423131 gnomAD-4.0.0 6.93103E-07 None None None None N None 0 0 None 0 0 None 0 0 9.07647E-07 0 0
A/T 16226 Fn3-5 72 None 0.1113 None 0.41 N 0.646 0.107 0.350088858571 gnomAD-4.0.0 1.38581E-06 None None None None N None 0 0 None 0 0 None 0 0 1.81494E-06 0 0
A/V 16226 Fn3-5 72 None 0.2021 None 0.581 N 0.68 0.174 0.499858025796 gnomAD-4.0.0 6.93103E-07 None None None None N None 0 0 None 0 2.57268E-05 None 0 0 0 0 0
I/N 16422 Fn3-6 72 None 0.3256 None 0.741 N 0.773 0.297 0.771231716895 gnomAD-4.0.0 6.84697E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99808E-07 0 0
I/T 16422 Fn3-6 72 rs746167353 0.1973 -2.743 0.117 N 0.722 0.175 0.633018970913 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
I/T 16422 Fn3-6 72 rs746167353 0.1973 -2.743 0.117 N 0.722 0.175 0.633018970913 gnomAD-4.0.0 1.78021E-05 None None None None N None 1.49692E-04 0 None 0 0 None 0 0 1.61965E-05 0 4.97611E-05
S/P 16622 Fn3-8 72 rs1178148859 0.9891 -0.092 0.998 D 0.728 0.5 0.493896554345 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 6.58762E-04 None 0 None 0 0 0
S/P 16622 Fn3-8 72 rs1178148859 0.9891 -0.092 0.998 D 0.728 0.5 0.493896554345 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.95236E-04 None 0 0 0 0 0
S/P 16622 Fn3-8 72 rs1178148859 0.9891 -0.092 0.998 D 0.728 0.5 0.493896554345 gnomAD-4.0.0 6.58233E-06 None None None None N None 0 0 None 0 1.95236E-04 None 0 0 0 0 0
Q/K 16823 Fn3-10 73 None 0.6775 None 0.997 N 0.605 0.363 0.326881540566 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
V/A 16925 Fn3-11 74 rs370067597 0.2874 -2.574 0.78 N 0.725 0.225 None gnomAD-2.1.1 4.66E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.02403E-04 0
V/A 16925 Fn3-11 74 rs370067597 0.2874 -2.574 0.78 N 0.725 0.225 None gnomAD-3.1.2 8.55E-05 None None None None N None 0 0 0 0 0 None 0 0 1.91362E-04 0 0
V/A 16925 Fn3-11 74 rs370067597 0.2874 -2.574 0.78 N 0.725 0.225 None gnomAD-4.0.0 1.72371E-04 None None None None N None 0 0 None 0 0 None 0 0 2.21312E-04 0 2.72445E-04
V/D 16925 Fn3-11 74 None 0.6944 None 0.984 N 0.851 0.446 0.82414934751 gnomAD-4.0.0 6.84546E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99768E-07 0 0
V/L 16925 Fn3-11 74 rs752224973 0.2093 -0.84 0.64 N 0.54 0.187 0.420447328233 gnomAD-2.1.1 8.09E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
V/L 16925 Fn3-11 74 rs752224973 0.2093 -0.84 0.64 N 0.54 0.187 0.420447328233 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/L 16925 Fn3-11 74 rs752224973 0.2093 -0.84 0.64 N 0.54 0.187 0.420447328233 gnomAD-4.0.0 1.36406E-05 None None None None N None 0 0 None 0 0 None 0 0 1.86548E-05 0 0
F/L 17118 Fn3-12 72 rs1161061741 0.9262 -1.903 0.454 N 0.541 0.317 0.524843318063 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
F/L 17118 Fn3-12 72 rs1161061741 0.9262 -1.903 0.454 N 0.541 0.317 0.524843318063 gnomAD-4.0.0 6.84493E-07 None None None None N None 0 0 None 0 2.52449E-05 None 0 0 0 0 0
F/V 17118 Fn3-12 72 None 0.5618 None 0.801 N 0.577 0.357 0.627942663015 gnomAD-4.0.0 6.84493E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99785E-07 0 0
L/V 17442 Fn3-14 74 rs2055526499 0.0711 None 0.003 N 0.385 0.067 0.514240282655 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06954E-04 0
L/V 17442 Fn3-14 74 rs2055526499 0.0711 None 0.003 N 0.385 0.067 0.514240282655 gnomAD-4.0.0 6.20279E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.09885E-04 0
V/I 17541 Fn3-15 72 rs772579140 0.0696 -0.908 0.011 N 0.201 0.072 0.391470661076 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 5.69E-05 None 0 None 0 0 0
K/E 17641 Fn3-16 73 rs1454839951 0.3692 None 0.101 N 0.523 0.186 0.180583059064 gnomAD-4.0.0 1.59271E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8611E-06 0 0
K/R 17641 Fn3-16 73 rs747537364 0.083 -1.288 0.001 N 0.235 0.087 0.221734844693 gnomAD-2.1.1 1.21E-05 None None None None N None 6.47E-05 0 None 0 0 None 0 None 4.64E-05 8.89E-06 0
K/R 17641 Fn3-16 73 rs747537364 0.083 -1.288 0.001 N 0.235 0.087 0.221734844693 gnomAD-4.0.0 4.77817E-06 None None None None N None 0 0 None 0 0 None 0 0 5.7223E-06 0 3.02773E-05
E/K 17934 Fn3-18 73 rs774287393 0.8944 -2.675 0.999 N 0.59 0.295 0.353548585375 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/K 17934 Fn3-18 73 rs774287393 0.8944 -2.675 0.999 N 0.59 0.295 0.353548585375 gnomAD-4.0.0 1.59461E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43526E-05 0
E/D 18138 Fn3-19 74 None 0.6346 None 0.425 N 0.515 0.081 0.275641507738 gnomAD-4.0.0 1.82077E-06 None None None None N None 0 0 None 0 2.86812E-05 None 0 0 0 0 0
E/Q 18138 Fn3-19 74 None 0.2185 None 0.01 N 0.254 0.148 0.192905019026 gnomAD-4.0.0 1.86926E-06 None None None None N None 0 0 None 0 0 None 0 0 3.29746E-06 0 0
Q/E 18243 Fn3-20 78 rs372447571 0.1314 -2.041 0.122 N 0.313 0.225 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
Q/E 18243 Fn3-20 78 rs372447571 0.1314 -2.041 0.122 N 0.313 0.225 None gnomAD-4.0.0 2.05395E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69994E-06 0 0
Q/H 18243 Fn3-20 78 rs548723690 0.5954 -2.017 0.998 N 0.679 0.323 0.28492961333 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 1.11757E-04 None 0 None 0 0 0
Q/H 18243 Fn3-20 78 rs548723690 0.5954 -2.017 0.998 N 0.679 0.323 0.28492961333 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 3.90168E-04 None 0 0 0 0 0
Q/H 18243 Fn3-20 78 rs548723690 0.5954 -2.017 0.998 N 0.679 0.323 0.28492961333 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
Q/H 18243 Fn3-20 78 rs548723690 0.5954 -2.017 0.998 N 0.679 0.323 0.28492961333 gnomAD-4.0.0 2.4804E-06 None None None None N None 0 0 None 0 8.93935E-05 None 0 0 0 0 0
R/I 18346 Fn3-21 75 rs573136400 0.2787 -1.236 0.781 N 0.775 0.302 None gnomAD-2.1.1 3.93E-05 None None None None N None 3.72362E-04 2.83E-05 None 0 0 None 3.27E-05 None 0 0 0
R/I 18346 Fn3-21 75 rs573136400 0.2787 -1.236 0.781 N 0.775 0.302 None gnomAD-3.1.2 6.58E-05 None None None None N None 2.41406E-04 0 0 0 0 None 0 0 0 0 0
R/I 18346 Fn3-21 75 rs573136400 0.2787 -1.236 0.781 N 0.775 0.302 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
R/I 18346 Fn3-21 75 rs573136400 0.2787 -1.236 0.781 N 0.775 0.302 None gnomAD-4.0.0 1.24001E-05 None None None None N None 2.26763E-04 0 None 0 0 None 0 0 0 1.09835E-05 3.20349E-05
F/C 18550 Fn3-22 72 rs553264256 0.4223 -0.99 1.0 N 0.734 0.485 0.781294814779 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07469E-04 0
F/C 18550 Fn3-22 72 rs553264256 0.4223 -0.99 1.0 N 0.734 0.485 0.781294814779 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
F/C 18550 Fn3-22 72 rs553264256 0.4223 -0.99 1.0 N 0.734 0.485 0.781294814779 gnomAD-4.0.0 6.57358E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07641E-04 0
F/L 18550 Fn3-22 72 rs1248662230 0.819 -1.761 0.061 N 0.337 0.236 0.384584525793 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.95E-06 0
F/L 18550 Fn3-22 72 rs1248662230 0.819 -1.761 0.061 N 0.337 0.236 0.384584525793 gnomAD-4.0.0 1.5964E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86717E-06 0 0
E/G 18656 Fn3-23 78 None 0.771 None 1.0 N 0.742 0.466 0.42264334713 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 18856 Fn3-24 73 rs762168752 0.3205 -2.171 0.91 N 0.695 0.185 0.412587454835 gnomAD-2.1.1 5.24E-06 None None None None N None 6.9E-05 0 None 0 0 None 0 None 0 0 0
V/A 18856 Fn3-24 73 rs762168752 0.3205 -2.171 0.91 N 0.695 0.185 0.412587454835 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
V/A 18856 Fn3-24 73 rs762168752 0.3205 -2.171 0.91 N 0.695 0.185 0.412587454835 gnomAD-4.0.0 5.66852E-06 None None None None N None 7.09195E-05 0 None 0 0 None 0 0 0 0 0
Q/H 18960 Fn3-25 77 rs377413828 0.6134 -1.292 0.999 N 0.623 0.345 0.254761474806 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
Q/H 18960 Fn3-25 77 rs377413828 0.6134 -1.292 0.999 N 0.623 0.345 0.254761474806 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/H 18960 Fn3-25 77 rs377413828 0.6134 -1.292 0.999 N 0.623 0.345 0.254761474806 gnomAD-4.0.0 2.56365E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78895E-06 0 0
Q/R 18960 Fn3-25 77 rs1250731428 0.4383 -0.694 0.997 N 0.591 0.267 0.281381271821 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
Q/R 18960 Fn3-25 77 rs1250731428 0.4383 -0.694 0.997 N 0.591 0.267 0.281381271821 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
Q/R 18960 Fn3-25 77 rs1250731428 0.4383 -0.694 0.997 N 0.591 0.267 0.281381271821 gnomAD-4.0.0 1.42571E-05 None None None None N None 0 0 None 0 0 None 0 0 1.94994E-05 0 0
E/D 19356 Fn3-28 73 None 0.9357 None 0.999 N 0.602 0.309 0.368369118721 gnomAD-4.0.0 8.40229E-06 None None None None N None 0 0 None 0 0 None 0 0 9.18756E-06 0 0
I/V 19551 Fn3-29 73 rs1264084790 0.0782 None 0.001 N 0.237 0.06 0.302793454619 gnomAD-4.0.0 3.18563E-06 None None None None N None 0 0 None 0 5.57569E-05 None 0 0 0 0 0
E/K 19651 Fn3-30 73 rs1442747427 0.7652 None 0.999 N 0.608 0.423 0.432154444652 gnomAD-4.0.0 3.18392E-06 None None None None N None 5.66059E-05 0 None 0 0 None 1.88239E-05 0 0 0 0
K/E 19754 Fn3-31 75 rs752302911 0.2668 -1.359 0.961 N 0.593 0.247 0.253726318573 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
K/E 19754 Fn3-31 75 rs752302911 0.2668 -1.359 0.961 N 0.593 0.247 0.253726318573 gnomAD-4.0.0 1.59184E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85945E-06 0 0
K/N 19754 Fn3-31 75 None 0.3934 None 0.248 N 0.474 0.077 0.0986583533028 gnomAD-4.0.0 6.84316E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65684E-05
L/F 19948 Fn3-32 72 None 0.1059 None 0.317 N 0.696 0.128 0.481246930725 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/K 20047 Fn3-33 71 rs371060708 0.1141 -1.146 None N 0.269 0.05 None gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 0 None 0 None 0 4.44E-05 0
R/K 20047 Fn3-33 71 rs371060708 0.1141 -1.146 None N 0.269 0.05 None gnomAD-3.1.2 4.6E-05 None None None None N None 0 0 0 0 0 None 0 0 8.83E-05 0 4.78469E-04
R/K 20047 Fn3-33 71 rs371060708 0.1141 -1.146 None N 0.269 0.05 None gnomAD-4.0.0 8.2439E-05 None None None None N None 1.33554E-05 0 None 0 0 None 0 0 1.11058E-04 0 1.60128E-05
E/K 20342 Fn3-35 72 rs1015533049 0.6371 None 0.999 N 0.601 0.387 0.390060412749 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/K 20342 Fn3-35 72 rs1015533049 0.6371 None 0.999 N 0.601 0.387 0.390060412749 gnomAD-4.0.0 1.23993E-06 None None None None N None 1.33551E-05 0 None 0 0 None 0 0 8.47877E-07 0 0
R/S 20444 Fn3-36 74 rs758056865 0.5717 -2.1 0.811 N 0.549 0.238 0.307016933798 gnomAD-2.1.1 4.19E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.2E-06 0
Y/C 20639 Fn3-37 71 rs756303390 0.2562 -1.332 0.978 N 0.601 0.355 None gnomAD-2.1.1 1.07E-05 None None None None N None 1.23987E-04 0 None 0 0 None 0 None 0 0 0
Y/C 20639 Fn3-37 71 rs756303390 0.2562 -1.332 0.978 N 0.601 0.355 None gnomAD-3.1.2 4.6E-05 None None None None N None 9.65E-05 1.96464E-04 0 0 0 None 0 0 0 0 0
Y/C 20639 Fn3-37 71 rs756303390 0.2562 -1.332 0.978 N 0.601 0.355 None gnomAD-4.0.0 1.36356E-05 None None None None N None 8.01111E-05 5.00167E-05 None 0 0 None 0 0 9.3251E-06 0 3.20287E-05
Y/H 20639 Fn3-37 71 rs727503587 0.3597 -2.522 0.921 N 0.535 0.195 None gnomAD-2.1.1 7.13E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.56E-05 0
Y/H 20639 Fn3-37 71 rs727503587 0.3597 -2.522 0.921 N 0.535 0.195 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
Y/H 20639 Fn3-37 71 rs727503587 0.3597 -2.522 0.921 N 0.535 0.195 None gnomAD-4.0.0 1.02519E-05 None None None None N None 0 0 None 0 0 None 0 0 1.9152E-05 0 0
E/D 20740 Fn3-38 73 rs766362512 0.4701 -1.568 0.183 N 0.501 0.093 0.290222751274 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/D 20740 Fn3-38 73 rs766362512 0.4701 -1.568 0.183 N 0.501 0.093 0.290222751274 gnomAD-4.0.0 1.59209E-06 None None None None N None 0 2.28812E-05 None 0 0 None 0 0 0 0 0
E/K 20740 Fn3-38 73 rs1451572769 0.4032 -0.358 0.101 N 0.525 0.183 None gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
E/K 20740 Fn3-38 73 rs1451572769 0.4032 -0.358 0.101 N 0.525 0.183 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 20740 Fn3-38 73 rs1451572769 0.4032 -0.358 0.101 N 0.525 0.183 None gnomAD-4.0.0 1.36367E-05 None None None None N None 0 0 None 0 0 None 0 0 1.69542E-05 0 3.20318E-05
E/V 20740 Fn3-38 73 rs559490402 0.2497 0.916 0.351 N 0.617 0.222 0.312001716656 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
E/V 20740 Fn3-38 73 rs559490402 0.2497 0.916 0.351 N 0.617 0.222 0.312001716656 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/V 20740 Fn3-38 73 rs559490402 0.2497 0.916 0.351 N 0.617 0.222 0.312001716656 gnomAD-4.0.0 4.33895E-06 None None None None N None 0 0 None 0 0 None 0 0 5.93408E-06 0 0
I/V 20935 Fn3-39 72 rs1249633842 0.0762 -1.558 0.993 N 0.407 0.16 0.600074432338 gnomAD-2.1.1 6.38E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.29634E-04 0
I/V 20935 Fn3-39 72 rs1249633842 0.0762 -1.558 0.993 N 0.407 0.16 0.600074432338 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/V 20935 Fn3-39 72 rs1249633842 0.0762 -1.558 0.993 N 0.407 0.16 0.600074432338 gnomAD-4.0.0 3.84737E-06 None None None None N None 0 0 None 0 0 None 0 0 7.18401E-06 0 0
K/E 21438 Fn3-43 73 None 0.4824 None 0.896 N 0.574 0.269 0.245660935333 gnomAD-4.0.0 1.59257E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86094E-06 0 0
I/L 21631 Fn3-44 73 rs757787828 0.0727 -0.609 None N 0.395 0.135 0.101711395817 gnomAD-4.0.0 3.4216E-06 None None None None N None 0 0 None 0 0 None 1.87259E-05 0 3.5984E-06 0 0
I/M 21631 Fn3-44 73 None 0.0699 None None N 0.321 0.052 0.21737058555 gnomAD-4.0.0 1.59187E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85956E-06 0 0
I/V 21631 Fn3-44 73 None 0.0671 None None N 0.18 0.163 0.187945064343 gnomAD-4.0.0 2.05296E-06 None None None None N None 2.98972E-05 0 None 0 0 None 0 1.73551E-04 0 0 1.65717E-05
E/A 22127 Fn3-48 73 rs1289473781 0.5508 -1.529 0.958 N 0.55 0.461 0.365317461125 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/A 22127 Fn3-48 73 rs1289473781 0.5508 -1.529 0.958 N 0.55 0.461 0.365317461125 gnomAD-4.0.0 3.18454E-06 None None None None N None 0 4.57436E-05 None 0 0 None 0 0 0 0 0
E/D 22127 Fn3-48 73 rs1208330464 0.8546 -1.481 0.958 N 0.483 0.268 0.282575091529 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
E/D 22127 Fn3-48 73 rs1208330464 0.8546 -1.481 0.958 N 0.483 0.268 0.282575091529 gnomAD-4.0.0 1.59227E-06 None None None None N None 0 0 None 0 2.77793E-05 None 0 0 0 0 0
F/S 22425 Fn3-50 72 None 0.6713 None 0.815 N 0.544 0.369 0.697227279014 gnomAD-4.0.0 3.18457E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86599E-05 0
I/V 23111 Fn3-55 72 rs1398776954 0.069 -1.53 None N 0.207 0.184 0.158396225186 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
I/V 23111 Fn3-55 72 rs1398776954 0.069 -1.53 None N 0.207 0.184 0.158396225186 gnomAD-4.0.0 5.47461E-06 None None None None N None 0 0 None 0 0 None 0 0 7.1969E-06 0 0
E/K 23211 Fn3-56 73 rs1215669622 0.4408 -1.39 1.0 N 0.583 0.369 0.326881540566 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
E/K 23211 Fn3-56 73 rs1215669622 0.4408 -1.39 1.0 N 0.583 0.369 0.326881540566 gnomAD-4.0.0 9.58008E-06 None None None None N None 0 0 None 0 5.04236E-05 None 0 1.73491E-04 8.99564E-06 1.15945E-05 0
E/Q 23211 Fn3-56 73 rs1215669622 0.1466 None 1.0 N 0.657 0.267 0.353974658523 gnomAD-4.0.0 6.84291E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99564E-07 0 0
F/L 23506 Fn3-58 72 rs753350142 0.8774 -1.595 0.001 N 0.275 0.294 0.548654159409 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
F/L 23506 Fn3-58 72 rs753350142 0.8774 -1.595 0.001 N 0.275 0.294 0.548654159409 gnomAD-4.0.0 1.59165E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85909E-06 0 0
T/S 23602 Fn3-59 71 None 0.1133 None 0.822 N 0.663 0.203 0.251116650651 gnomAD-4.0.0 1.59192E-06 None None None None N None 0 0 None 0 0 None 0 2.41429E-04 0 0 0
Q/H 23798 Fn3-60 73 None 0.7021 None 0.999 N 0.599 0.329 0.223146558224 gnomAD-4.0.0 1.5929E-06 None None None None N None 0 0 None 0 0 None 0 2.41546E-04 0 0 0
Q/P 23798 Fn3-60 73 None 0.9914 None 0.999 N 0.645 0.451 0.555595671355 gnomAD-4.0.0 1.59297E-06 None None None None N None 0 2.28927E-05 None 0 0 None 0 0 0 0 0
E/G 23898 Fn3-61 73 None 0.7773 None 0.988 N 0.755 0.577 0.531922418639 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/A 23996 Fn3-62 73 rs769265681 0.3768 -1.241 0.999 N 0.655 0.582 0.484691182572 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
E/A 23996 Fn3-62 73 rs769265681 0.3768 -1.241 0.999 N 0.655 0.582 0.484691182572 gnomAD-4.0.0 1.59168E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8591E-06 0 0
I/L 24194 Fn3-63 73 rs746396020 0.107 -1.114 0.084 N 0.443 0.078 0.539835882356 gnomAD-2.1.1 5.96E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.19E-05 0
I/L 24194 Fn3-63 73 rs746396020 0.107 -1.114 0.084 N 0.443 0.078 0.539835882356 gnomAD-4.0.0 1.95229E-06 None None None None N None 0 0 None 0 0 None 0 0 3.37687E-06 0 0
E/A 24294 Fn3-64 73 rs766386367 0.4431 -2.119 0.999 N 0.653 0.547 0.523910806359 gnomAD-2.1.1 2.06E-05 None None None None N None 0 1.48518E-04 None 0 0 None 0 None 0 0 0
E/A 24294 Fn3-64 73 rs766386367 0.4431 -2.119 0.999 N 0.653 0.547 0.523910806359 gnomAD-4.0.0 8.05065E-06 None None None None N None 0 1.16009E-04 None 0 0 None 0 0 0 0 0
E/K 24294 Fn3-64 73 rs1708891748 0.7806 None 0.999 N 0.585 0.38 0.383590876969 gnomAD-4.0.0 6.87736E-07 None None None None N None 0 0 None 0 0 None 0 0 9.0292E-07 0 0
S/C 24686 Fn3-67 71 rs727504921 0.0867 -0.395 0.985 N 0.696 0.271 0.439018943094 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
S/C 24686 Fn3-67 71 rs727504921 0.0867 -0.395 0.985 N 0.696 0.271 0.439018943094 gnomAD-4.0.0 6.36981E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.73329E-05 0
S/F 24686 Fn3-67 71 rs727504921 0.155 -0.509 0.034 N 0.639 0.171 0.377451072189 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 1.66722E-04
S/F 24686 Fn3-67 71 rs727504921 0.155 -0.509 0.034 N 0.639 0.171 0.377451072189 gnomAD-4.0.0 6.36981E-06 None None None None N None 0 0 None 0 0 None 0 0 1.14389E-05 0 0
Q/H 24880 Fn3-68 73 rs755733728 0.6428 -2.02 0.99 N 0.622 0.324 0.430351802785 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 0 0
Q/H 24880 Fn3-68 73 rs755733728 0.6428 -2.02 0.99 N 0.622 0.324 0.430351802785 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
Q/H 24880 Fn3-68 73 rs755733728 0.6428 -2.02 0.99 N 0.622 0.324 0.430351802785 gnomAD-4.0.0 6.81882E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.20781E-04 0
Q/P 24880 Fn3-68 73 None 0.9807 None 0.99 N 0.663 0.455 0.568180043242 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
E/D 25078 Fn3-70 73 None 0.5792 None 0.979 N 0.559 0.282 0.210429274316 gnomAD-4.0.0 1.59173E-06 None None None None N None 0 0 None 0 2.77531E-05 None 0 0 0 0 0
E/G 25078 Fn3-70 73 rs1223037515 0.8329 -2.294 0.988 N 0.709 0.46 0.486060746414 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
E/G 25078 Fn3-70 73 rs1223037515 0.8329 -2.294 0.988 N 0.709 0.46 0.486060746414 gnomAD-4.0.0 4.79008E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29708E-06 0 0
E/K 25078 Fn3-70 73 None 0.8104 None 0.919 N 0.596 0.303 0.28492961333 gnomAD-4.0.0 6.84298E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99578E-07 0 0
E/Q 25078 Fn3-70 73 None 0.3894 None 0.958 N 0.631 0.29 0.208000267992 gnomAD-4.0.0 2.73719E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59831E-06 0 0
T/I 25276 Fn3-71 73 rs748746031 0.0412 -0.729 None N 0.319 0.127 0.16115917748 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
T/I 25276 Fn3-71 73 rs748746031 0.0412 -0.729 None N 0.319 0.127 0.16115917748 gnomAD-4.0.0 1.59235E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02682E-05
N/D 25478 Fn3-73 74 rs752247447 0.178 -1.689 0.285 N 0.522 0.126 0.214338557667 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/D 25478 Fn3-73 74 rs752247447 0.178 -1.689 0.285 N 0.522 0.126 0.214338557667 gnomAD-4.0.0 3.18589E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86714E-05 0
L/I 25768 Fn3-75 71 rs541266544 0.0802 -0.658 0.134 N 0.505 0.123 0.438170831126 gnomAD-2.1.1 1.10953E-04 None None None None N None 0 0 None 0 5.15E-05 None 9.48394E-04 None 0 0 1.40805E-04
L/I 25768 Fn3-75 71 rs541266544 0.0802 -0.658 0.134 N 0.505 0.123 0.438170831126 gnomAD-3.1.2 5.26E-05 None None None None N None 0 0 0 0 0 None 0 0 0 1.657E-03 0
L/I 25768 Fn3-75 71 rs541266544 0.0802 -0.658 0.134 N 0.505 0.123 0.438170831126 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 0 0 None None None 2E-03 None
L/I 25768 Fn3-75 71 rs541266544 0.0802 -0.658 0.134 N 0.505 0.123 0.438170831126 gnomAD-4.0.0 6.13697E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.03238E-03 8.00615E-05
L/P 25768 Fn3-75 71 rs572569285 0.9192 -1.497 0.996 N 0.623 0.338 0.785001498622 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
L/P 25768 Fn3-75 71 rs572569285 0.9192 -1.497 0.996 N 0.623 0.338 0.785001498622 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07297E-04 0
L/P 25768 Fn3-75 71 rs572569285 0.9192 -1.497 0.996 N 0.623 0.338 0.785001498622 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
L/P 25768 Fn3-75 71 rs572569285 0.9192 -1.497 0.996 N 0.623 0.338 0.785001498622 gnomAD-4.0.0 2.56364E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.68147E-05 0
L/V 25768 Fn3-75 71 rs541266544 0.0773 None 0.704 N 0.612 0.182 0.441844919209 gnomAD-4.0.0 2.73782E-06 None None None None N None 0 0 None 0 2.52309E-05 None 0 0 0 0 4.9715E-05
E/D 26062 Fn3-77 73 None 0.692 None 0.999 N 0.557 0.325 0.405012372841 gnomAD-4.0.0 1.59178E-06 None None None None N None 0 0 None 0 0 None 1.88239E-05 0 0 0 0
E/A 26160 Fn3-78 73 None 0.6212 None 0.896 N 0.689 0.491 0.408172294925 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 1.01626E-03 None 0 0 None 0 0 0 0 0
V/I 26358 Fn3-79 73 rs774747865 0.0524 -0.355 None N 0.189 0.087 None gnomAD-2.1.1 3.93E-05 None None None None N None 2.48077E-04 1.41411E-04 None 0 0 None 0 None 0 0 0
V/I 26358 Fn3-79 73 rs774747865 0.0524 -0.355 None N 0.189 0.087 None gnomAD-3.1.2 8.55E-05 None None None None N None 3.13813E-04 0 0 0 0 None 0 0 0 0 0
V/I 26358 Fn3-79 73 rs774747865 0.0524 -0.355 None N 0.189 0.087 None gnomAD-4.0.0 1.85938E-05 None None None None N None 2.93835E-04 1.00063E-04 None 0 0 None 0 0 0 0 3.20318E-05
E/D 26458 Fn3-80 73 rs1162274016 0.8688 -1.475 0.958 N 0.598 0.303 0.210429274316 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
E/D 26458 Fn3-80 73 rs1162274016 0.8688 -1.475 0.958 N 0.598 0.303 0.210429274316 gnomAD-4.0.0 1.59216E-06 None None None None N None 0 0 None 0 2.77546E-05 None 0 0 0 0 0
K/E 26560 Fn3-81 74 rs994825543 0.2127 None 0.885 N 0.662 0.249 0.272639205421 gnomAD-4.0.0 3.42168E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59807E-06 0 1.65689E-05
K/T 26560 Fn3-81 74 None 0.1737 None 0.982 N 0.679 0.375 0.353974658523 gnomAD-4.0.0 1.59196E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43279E-05 0
Q/H 26850 Fn3-83 71 rs1705482872 0.1302 None None N 0.293 0.067 0.110078149338 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
Q/H 26850 Fn3-83 71 rs1705482872 0.1302 None None N 0.293 0.067 0.110078149338 gnomAD-4.0.0 6.57436E-06 None None None None N None 2.41324E-05 0 None 0 0 None 0 0 0 0 0
Q/H 27044 Fn3-84 73 None 0.6256 None 0.99 N 0.611 0.292 0.285698343383 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/L 27044 Fn3-84 73 None 0.3231 None 0.698 N 0.647 0.39 0.559847471112 gnomAD-4.0.0 1.59341E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8609E-06 0 0
Q/R 27044 Fn3-84 73 None 0.3593 None 0.904 N 0.623 0.349 0.202086224978 gnomAD-4.0.0 6.37365E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8609E-06 4.31258E-05 0
E/G 27144 Fn3-85 73 rs794729512 0.6929 None 1.0 D 0.755 0.561 0.63502316858 gnomAD-4.0.0 8.40225E-06 None None None None N None 0 0 None 0 0 None 0 0 9.18751E-06 0 0
E/G 27242 Fn3-86 73 None 0.8623 None 1.0 N 0.759 0.522 0.566919426312 gnomAD-4.0.0 1.36873E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79906E-06 0 0
E/V 27242 Fn3-86 73 rs1210575101 0.7057 1.259 1.0 N 0.777 0.53 0.487843537783 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/V 27242 Fn3-86 73 rs1210575101 0.7057 1.259 1.0 N 0.777 0.53 0.487843537783 gnomAD-4.0.0 6.84363E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15947E-05 0
N/D 27643 Fn3-89 74 rs1457183253 0.1566 -1.802 0.379 N 0.634 0.134 0.177238962908 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/D 27643 Fn3-89 74 rs1457183253 0.1566 -1.802 0.379 N 0.634 0.134 0.177238962908 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 0 4.14422E-04 0
N/D 27643 Fn3-89 74 rs1457183253 0.1566 -1.802 0.379 N 0.634 0.134 0.177238962908 gnomAD-4.0.0 7.68596E-06 None None None None N None 0 0 None 0 0 None 0 0 0 8.04074E-05 0
Y/C 27837 Fn3-90 72 rs1324677540 0.1573 -1.237 0.992 N 0.709 0.333 0.735914652579 gnomAD-2.1.1 4.09E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.97E-06 0
Y/C 27837 Fn3-90 72 rs1324677540 0.1573 -1.237 0.992 N 0.709 0.333 0.735914652579 gnomAD-4.0.0 1.60393E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87135E-06 0 0
V/A 27933 Fn3-91 71 rs879145639 0.0992 -2.231 None N 0.279 0.069 0.290222751274 gnomAD-2.1.1 7.21E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.57E-05 0
V/A 27933 Fn3-91 71 rs879145639 0.0992 -2.231 None N 0.279 0.069 0.290222751274 gnomAD-3.1.2 1.31E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
V/A 27933 Fn3-91 71 rs879145639 0.0992 -2.231 None N 0.279 0.069 0.290222751274 gnomAD-4.0.0 9.92531E-06 None None None None N None 0 1.67191E-05 None 0 0 None 0 0 1.27201E-05 0 0
V/L 27933 Fn3-91 71 None 0.0797 None 0.002 N 0.501 0.044 0.324161360171 gnomAD-4.0.0 1.59613E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86393E-06 0 0
E/K 28226 Fn3-93 73 rs2154159665 0.8101 None 0.698 N 0.66 0.262 0.290962096972 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06868E-04 0
E/K 28226 Fn3-93 73 rs2154159665 0.8101 None 0.698 N 0.66 0.262 0.290962096972 gnomAD-4.0.0 2.02963E-06 None None None None N None 0 0 None 0 0 None 0 0 1.20494E-06 4.69704E-05 0
E/K 28324 Fn3-94 73 None 0.8692 None 0.014 N 0.515 0.286 0.208816687407 gnomAD-4.0.0 1.59155E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85807E-06 0 0
I/T 28522 Fn3-95 73 rs372146722 0.2916 -2.337 0.892 N 0.723 0.376 None gnomAD-2.1.1 8.09E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 8.96E-06 0
I/T 28522 Fn3-95 73 rs372146722 0.2916 -2.337 0.892 N 0.723 0.376 None gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/T 28522 Fn3-95 73 rs372146722 0.2916 -2.337 0.892 N 0.723 0.376 None gnomAD-4.0.0 1.36375E-05 None None None None N None 0 3.337E-05 None 0 0 None 0 0 1.61058E-05 0 1.60195E-05
V/I 28722 Fn3-97 72 None 0.0672 None 0.004 N 0.451 0.071 0.162503812791 gnomAD-4.0.0 1.59135E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85817E-06 0 0
Y/F 28916 Fn3-98 72 None 0.1128 None 0.005 N 0.271 0.199 0.408853032482 gnomAD-4.0.0 2.73711E-06 None None None None N None 0 0 None 0 0 None 0 6.93963E-04 0 0 0
Y/H 28916 Fn3-98 72 None 0.3887 None 0.988 N 0.662 0.421 0.543384585148 gnomAD-4.0.0 6.8428E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99577E-07 0 0
F/L 29012 Fn3-99 71 None 0.6366 None 0.477 N 0.579 0.326 0.468168183122 gnomAD-4.0.0 1.5914E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85799E-06 0 0
F/V 29012 Fn3-99 71 None 0.137 None 0.645 N 0.584 0.419 0.623909720503 gnomAD-4.0.0 1.5914E-06 None None None None N None 0 0 None 0 2.77948E-05 None 0 0 0 0 0
E/G 29309 Fn3-101 73 rs1208405934 0.8204 None 1.0 N 0.732 0.582 0.550005317886 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92456E-04 None 0 0 0 0 0
E/G 29309 Fn3-101 73 rs1208405934 0.8204 None 1.0 N 0.732 0.582 0.550005317886 gnomAD-4.0.0 6.5703E-06 None None None None I None 0 0 None 0 1.92456E-04 None 0 0 0 0 0
I/L 29605 Fn3-103 73 rs755867567 0.1068 -0.37 0.025 N 0.465 0.086 0.141422826196 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
I/N 29605 Fn3-103 73 rs906583017 0.3006 -1.797 0.667 N 0.763 0.299 0.530011692926 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
I/N 29605 Fn3-103 73 rs906583017 0.3006 -1.797 0.667 N 0.763 0.299 0.530011692926 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/N 29605 Fn3-103 73 rs906583017 0.3006 -1.797 0.667 N 0.763 0.299 0.530011692926 gnomAD-4.0.0 1.31506E-05 None None None None N None 0 0 None 0 0 None 0 0 2.94048E-05 0 0
Q/H 29705 Fn3-104 73 None 0.5302 None 0.003 D 0.56 0.149 0.166414681773 gnomAD-4.0.0 1.23202E-05 None None None None N None 0 0 None 0 0 None 0 0 1.52909E-05 0 1.65667E-05
Q/R 29705 Fn3-104 73 rs752538734 0.469 -1.21 0.324 N 0.722 0.183 0.204665344411 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
Q/R 29705 Fn3-104 73 rs752538734 0.469 -1.21 0.324 N 0.722 0.183 0.204665344411 gnomAD-4.0.0 1.09514E-05 None None None None N None 0 0 None 0 0 None 0 0 1.43915E-05 0 0
Y/C 29807 Fn3-105 74 None 0.126 None 0.997 N 0.618 0.31 0.454987352986 gnomAD-4.0.0 2.05259E-06 None None None None N None 0 0 None 0 0 None 0 0 2.6984E-06 0 0
Y/S 29807 Fn3-105 74 None 0.152 None 0.966 N 0.592 0.323 0.522182809586 gnomAD-4.0.0 6.84196E-07 None None None None N None 2.98704E-05 0 None 0 0 None 0 0 0 0 0
F/V 30004 Fn3-106 72 rs1238583004 0.524 -2.113 1.0 N 0.72 0.472 0.781133240969 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
F/V 30004 Fn3-106 72 rs1238583004 0.524 -2.113 1.0 N 0.72 0.472 0.781133240969 gnomAD-4.0.0 1.59126E-06 None None None None N None 0 0 None 0 2.77577E-05 None 0 0 0 0 0
E/K 30100 Fn3-107 71 rs762287310 0.5162 0.322 0.852 N 0.567 0.264 0.246773566709 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
E/K 30100 Fn3-107 71 rs762287310 0.5162 0.322 0.852 N 0.567 0.264 0.246773566709 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 30100 Fn3-107 71 rs762287310 0.5162 0.322 0.852 N 0.567 0.264 0.246773566709 gnomAD-4.0.0 6.57229E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47011E-05 0 0
E/Q 30100 Fn3-107 71 rs762287310 0.2129 None 0.31 N 0.299 0.202 0.242825505644 gnomAD-4.0.0 1.36837E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79886E-06 0 0
Q/P 30296 Fn3-108 73 None 0.9751 None 0.999 D 0.568 0.455 0.582387198248 gnomAD-4.0.0 1.59307E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86221E-06 0 0
E/K 30493 Fn3-110 72 None 0.8403 None 0.999 N 0.611 0.39 0.339316883193 gnomAD-4.0.0 4.7771E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57927E-06 0 0
Q/E 30691 Fn3-111 73 rs573510674 0.146 -1.971 0.992 N 0.49 0.356 0.322230723748 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 1.67187E-04 None 0 None 0 0 0
Q/E 30691 Fn3-111 73 rs573510674 0.146 -1.971 0.992 N 0.49 0.356 0.322230723748 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 3.85208E-04 None 0 0 0 0 0
Q/E 30691 Fn3-111 73 rs573510674 0.146 -1.971 0.992 N 0.49 0.356 0.322230723748 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
Q/E 30691 Fn3-111 73 rs573510674 0.146 -1.971 0.992 N 0.49 0.356 0.322230723748 gnomAD-4.0.0 3.71798E-06 None None None None N None 0 0 None 0 1.33726E-04 None 0 0 0 0 0
Q/R 30691 Fn3-111 73 rs369434118 0.2192 -1.007 0.997 N 0.577 0.422 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
Q/R 30691 Fn3-111 73 rs369434118 0.2192 -1.007 0.997 N 0.577 0.422 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/R 30691 Fn3-111 73 rs369434118 0.2192 -1.007 0.997 N 0.577 0.422 None gnomAD-4.0.0 6.56987E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46985E-05 0 0
E/G 30792 Fn3-112 74 None 0.8185 None 1.0 D 0.693 0.585 0.52297913765 gnomAD-4.0.0 1.59113E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85783E-06 0 0
E/K 30792 Fn3-112 74 rs759221234 0.8504 -0.764 0.999 N 0.637 0.368 0.364926071151 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 9.94E-05 0 None 0 None 0 0 0
K/E 30893 Fn3-113 73 rs370541682 0.2576 -1.74 0.999 N 0.639 0.447 None gnomAD-2.1.1 3.21E-05 None None None None N None 2.89304E-04 2.83E-05 None 0 0 None 0 None 0 7.81E-06 0
K/E 30893 Fn3-113 73 rs370541682 0.2576 -1.74 0.999 N 0.639 0.447 None gnomAD-3.1.2 9.85E-05 None None None None N None 2.8945E-04 1.30941E-04 0 0 0 None 0 0 0 0 4.78011E-04
K/E 30893 Fn3-113 73 rs370541682 0.2576 -1.74 0.999 N 0.639 0.447 None gnomAD-4.0.0 2.23072E-05 None None None None N None 3.60356E-04 6.66733E-05 None 0 0 None 0 0 2.54269E-06 0 3.20205E-05
Y/S 31087 Fn3-114 72 rs901131458 0.3137 None 0.891 N 0.584 0.28 0.723393103801 gnomAD-4.0.0 2.05256E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79888E-06 0 1.65645E-05
E/G 31183 Fn3-115 71 None 0.557 None 0.994 N 0.653 0.477 0.476364732183 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/A 31380 Fn3-116 73 rs764500703 0.0763 -0.344 0.005 N 0.458 0.097 0.273070737957 gnomAD-2.1.1 1.21E-05 None None None None N None 0 8.74E-05 None 0 0 None 0 None 0 0 0
S/A 31380 Fn3-116 73 rs764500703 0.0763 -0.344 0.005 N 0.458 0.097 0.273070737957 gnomAD-4.0.0 4.7789E-06 None None None None N None 0 6.87128E-05 None 0 0 None 0 0 0 0 0
Q/E 31480 Fn3-117 73 None 0.2704 None 0.992 N 0.481 0.412 0.282179105231 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/H 31480 Fn3-117 73 rs1182145400 0.8203 -1.671 0.999 N 0.732 0.387 0.316494231283 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
Q/H 31480 Fn3-117 73 rs1182145400 0.8203 -1.671 0.999 N 0.732 0.387 0.316494231283 gnomAD-4.0.0 1.59132E-06 None None None None N None 0 0 None 0 2.77285E-05 None 0 0 0 0 0
E/A 31581 Fn3-118 76 rs1321907057 0.5766 -1.559 0.998 N 0.664 0.496 0.459282285925 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
E/A 31581 Fn3-118 76 rs1321907057 0.5766 -1.559 0.998 N 0.664 0.496 0.459282285925 gnomAD-4.0.0 3.18272E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71706E-06 0 0
E/K 31581 Fn3-118 76 rs1417917395 0.7964 None 0.998 N 0.607 0.401 0.345175991111 gnomAD-4.0.0 4.78956E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39696E-06 0 1.65662E-05
E/Q 31581 Fn3-118 76 None 0.3555 None 0.999 N 0.68 0.352 0.248417906384 gnomAD-4.0.0 6.84223E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99494E-07 0 0
I/T 31779 Fn3-119 72 rs1460359915 0.1934 -2.535 0.001 N 0.54 0.118 0.626236102369 gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 5.12E-05 None 0 None 0 1.56E-05 0
I/T 31779 Fn3-119 72 rs1460359915 0.1934 -2.535 0.001 N 0.54 0.118 0.626236102369 gnomAD-3.1.2 2.63E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 4.41E-05 0 0
I/T 31779 Fn3-119 72 rs1460359915 0.1934 -2.535 0.001 N 0.54 0.118 0.626236102369 gnomAD-4.0.0 1.4872E-05 None None None None N None 1.33461E-05 0 None 0 0 None 0 0 1.6952E-05 0 4.80338E-05
I/V 31779 Fn3-119 72 rs886039071 0.068 None None N 0.211 0.071 0.363751660372 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 31779 Fn3-119 72 rs886039071 0.068 None None N 0.211 0.071 0.363751660372 gnomAD-4.0.0 6.57091E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47003E-05 0 0
S/F 31982 Fn3-121 74 None 0.1227 None 0.602 N 0.73 0.273 0.514587094315 gnomAD-4.0.0 1.36845E-06 None None None None N None 0 0 None 0 0 None 0 0 1.799E-06 0 0
Y/N 32176 Fn3-122 72 rs377291343 0.6277 -1.974 0.999 N 0.714 0.47 None gnomAD-2.1.1 1.43E-05 None None None None N None 1.65303E-04 0 None 0 0 None 0 None 0 0 0
Y/N 32176 Fn3-122 72 rs377291343 0.6277 -1.974 0.999 N 0.714 0.47 None gnomAD-3.1.2 5.91E-05 None None None None N None 1.92994E-04 6.55E-05 0 0 0 None 0 0 0 0 0
Y/N 32176 Fn3-122 72 rs377291343 0.6277 -1.974 0.999 N 0.714 0.47 None gnomAD-4.0.0 8.05597E-06 None None None None N None 1.60171E-04 1.66706E-05 None 0 0 None 0 0 0 0 0
V/A 32471 Fn3-124 73 rs1412547429 0.5859 None 0.999 N 0.611 0.34 0.658862992856 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 32471 Fn3-124 73 rs1412547429 0.5859 None 0.999 N 0.611 0.34 0.658862992856 gnomAD-4.0.0 6.57203E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47024E-05 0 0
R/S 32672 Fn3-126 73 None 0.5152 None 0.961 N 0.574 0.337 0.326616659874 gnomAD-4.0.0 1.59145E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85887E-06 0 0
H/L 32867 Fn3-127 73 None 0.1886 None 1.0 N 0.712 0.52 0.758974145601 gnomAD-4.0.0 4.77351E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71634E-06 0 3.02407E-05
Q/H 32969 Fn3-128 74 rs1018386868 0.5095 -1.199 0.999 N 0.6 0.322 0.369495900351 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
Q/H 32969 Fn3-128 74 rs1018386868 0.5095 -1.199 0.999 N 0.6 0.322 0.369495900351 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/H 32969 Fn3-128 74 rs1018386868 0.5095 -1.199 0.999 N 0.6 0.322 0.369495900351 gnomAD-4.0.0 1.42531E-05 None None None None N None 0 0 None 0 0 None 0 0 1.78004E-05 0 3.20256E-05
Q/K 32969 Fn3-128 74 None 0.3133 None 0.99 N 0.581 0.333 0.314716216878 gnomAD-4.0.0 3.18276E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86566E-05 0
Q/R 32969 Fn3-128 74 rs727504185 0.2987 -0.41 0.99 N 0.565 0.264 0.283371740733 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
Q/R 32969 Fn3-128 74 rs727504185 0.2987 -0.41 0.99 N 0.565 0.264 0.283371740733 gnomAD-4.0.0 1.36846E-06 None None None None N None 0 0 None 0 5.0388E-05 None 0 0 0 0 0
E/Q 33070 Fn3-129 73 rs1263382518 0.5024 -0.895 1.0 N 0.691 0.354 0.304760801415 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
Y/F 33363 Fn3-130 74 rs774468606 0.1323 -0.516 0.999 N 0.605 0.376 0.480497669815 gnomAD-2.1.1 3.63E-05 None None None None N None 0 0 None 0 0 None 0 None 0 8.02E-05 0
Y/F 33363 Fn3-130 74 rs774468606 0.1323 -0.516 0.999 N 0.605 0.376 0.480497669815 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Y/F 33363 Fn3-130 74 rs774468606 0.1323 -0.516 0.999 N 0.605 0.376 0.480497669815 gnomAD-4.0.0 8.6781E-06 None None None None N None 0 0 None 0 0 None 0 0 1.18682E-05 0 0
E/A 33464 Fn3-131 73 rs1480074410 0.4626 -1.091 0.999 N 0.674 0.547 0.450733807028 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
E/A 33464 Fn3-131 73 rs1480074410 0.4626 -1.091 0.999 N 0.674 0.547 0.450733807028 gnomAD-4.0.0 3.18292E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71654E-06 0 0
E/K 33464 Fn3-131 73 None 0.6986 -0.798 1.0 N 0.631 0.434 None gnomAD-2.1.1 7.14E-06 None None None None N None 0 0 None 0 1.02575E-04 None 0 None 0 0 0
E/K 33464 Fn3-131 73 None 0.6986 -0.798 1.0 N 0.631 0.434 None gnomAD-3.1.2 2.63E-05 None None None None N None 7.24E-05 0 0 0 1.9253E-04 None 0 0 0 0 0
E/K 33464 Fn3-131 73 None 0.6986 -0.798 1.0 N 0.631 0.434 None gnomAD-4.0.0 7.43661E-06 None None None None N None 9.34305E-05 1.66706E-05 None 0 2.22816E-05 None 0 0 8.47614E-07 1.09801E-05 1.60123E-05
E/Q 33464 Fn3-131 73 rs374920916 0.3269 None 1.0 N 0.696 0.321 0.350746614512 gnomAD-4.0.0 6.84263E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99486E-07 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.