Structural position:

  • Domain Type: Fn3
  • Aligned Position: 11
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand A

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
T/I 15766 Fn3-2 9 None 0.1152 None None N 0.167 0.097 0.247872288689 gnomAD-4.0.0 1.59446E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86311E-06 0 0
T/N 15766 Fn3-2 9 rs773613340 0.0828 -0.233 0.017 N 0.326 0.099 0.251639045875 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
T/N 15766 Fn3-2 9 rs773613340 0.0828 -0.233 0.017 N 0.326 0.099 0.251639045875 gnomAD-4.0.0 3.18892E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72623E-06 0 0
T/S 15766 Fn3-2 9 rs878854312 0.0813 None 0.003 N 0.271 0.084 0.184867976434 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/S 15766 Fn3-2 9 rs878854312 0.0813 None 0.003 N 0.271 0.084 0.184867976434 gnomAD-4.0.0 2.5671E-06 None None None None N None 0 0 None 0 0 None 0 0 4.79425E-06 0 0
T/A 16559 Fn3-8 9 rs772176256 0.0777 -0.794 0.027 N 0.473 0.059 0.119812018005 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/A 16559 Fn3-8 9 rs772176256 0.0777 -0.794 0.027 N 0.473 0.059 0.119812018005 gnomAD-4.0.0 1.3693E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31965E-05 0
T/I 16559 Fn3-8 9 None 0.0647 None None N 0.347 0.055 0.134241683229 gnomAD-4.0.0 6.84644E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99868E-07 0 0
E/K 16659 Fn3-9 9 rs778767799 0.6271 0.158 0.98 N 0.551 0.301 0.250039746154 gnomAD-2.1.1 4.13E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.25E-06 0
E/K 16659 Fn3-9 9 rs778767799 0.6271 0.158 0.98 N 0.551 0.301 0.250039746154 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 9.45E-05 0 0 0 0
E/K 16659 Fn3-9 9 rs778767799 0.6271 0.158 0.98 N 0.551 0.301 0.250039746154 gnomAD-4.0.0 6.4271E-06 None None None None N None 0 0 None 0 0 None 1.58519E-05 0 9.59168E-06 0 0
A/T 16759 Fn3-10 9 rs1374450831 0.0561 -0.633 None N 0.195 0.128 0.0716867268079 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 5.7E-05 None 0 None 0 0 0
A/T 16759 Fn3-10 9 rs1374450831 0.0561 -0.633 None N 0.195 0.128 0.0716867268079 gnomAD-4.0.0 1.37026E-06 None None None None N None 0 0 None 0 5.08053E-05 None 0 0 0 0 0
H/N 16860 Fn3-11 9 None 0.2906 None 0.999 N 0.531 0.324 0.330069100803 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/R 16860 Fn3-11 9 rs2154199864 0.1728 None 1.0 N 0.667 0.312 0.301455362545 gnomAD-4.0.0 4.77897E-06 None None None None N None 0 0 None 0 2.7818E-05 None 0 0 5.72249E-06 0 0
E/G 17155 Fn3-13 9 rs926188442 0.5029 None 0.645 N 0.676 0.373 0.353974658523 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 0 0 9.57854E-04
E/G 17155 Fn3-13 9 rs926188442 0.5029 None 0.645 N 0.676 0.373 0.353974658523 gnomAD-4.0.0 1.31638E-05 None None None None N None 0 0 None 0 0 None 0 0 0 0 9.57854E-04
E/V 17155 Fn3-13 9 None 0.3074 None 0.864 N 0.753 0.393 0.414021929199 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/M 17478 Fn3-15 9 rs554368924 0.0846 -0.349 0.304 N 0.412 0.033 0.289474373501 gnomAD-2.1.1 2.98E-05 None None None None N None 0 0 None 0 0 None 0 None 0 5.74E-05 1.46113E-04
I/M 17478 Fn3-15 9 rs554368924 0.0846 -0.349 0.304 N 0.412 0.033 0.289474373501 gnomAD-3.1.2 3.95E-05 None None None None N None 2.41E-05 6.56E-05 0 0 0 None 0 0 5.89E-05 0 0
I/M 17478 Fn3-15 9 rs554368924 0.0846 -0.349 0.304 N 0.412 0.033 0.289474373501 gnomAD-4.0.0 1.80627E-05 None None None None N None 1.3389E-05 3.38834E-05 None 0 0 None 0 0 2.04165E-05 0 3.21906E-05
I/T 17478 Fn3-15 9 rs1178377744 0.0734 -0.663 0.001 N 0.159 0.052 0.1749357433 gnomAD-2.1.1 1.27E-05 None None None None N None 0 0 None 0 0 None 3.46E-05 None 0 1.88E-05 0
I/T 17478 Fn3-15 9 rs1178377744 0.0734 -0.663 0.001 N 0.159 0.052 0.1749357433 gnomAD-4.0.0 8.0622E-06 None None None None N None 0 0 None 0 0 None 0 0 1.15764E-05 1.46024E-05 0
T/A 17870 Fn3-18 9 rs758041223 0.1616 -0.728 0.022 N 0.168 0.109 0.126345400529 gnomAD-2.1.1 1.71E-05 None None None None N None 0 0 None 0 2.29331E-04 None 0 None 0 0 0
T/A 17870 Fn3-18 9 rs758041223 0.1616 -0.728 0.022 N 0.168 0.109 0.126345400529 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94704E-04 None 0 0 0 0 0
T/A 17870 Fn3-18 9 rs758041223 0.1616 -0.728 0.022 N 0.168 0.109 0.126345400529 gnomAD-4.0.0 4.4229E-06 None None None None N None 0 0 None 0 1.5835E-04 None 0 0 0 0 0
T/I 17870 Fn3-18 9 rs1553683359 0.3348 None 0.669 N 0.511 0.186 0.339793275041 gnomAD-4.0.0 6.98284E-07 None None None None N None 3.06843E-05 0 None 0 0 None 0 0 0 0 0
T/P 17870 Fn3-18 9 None 0.8332 None 0.966 N 0.585 0.305 0.397540356873 gnomAD-4.0.0 6.98982E-07 None None None None N None 0 0 None 0 0 None 0 0 9.14246E-07 0 0
A/S 18073 Fn3-19 9 None 0.096 None 0.018 N 0.251 0.09 0.195762928549 gnomAD-4.0.0 6.84976E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00122E-07 0 0
A/V 18073 Fn3-19 9 None 0.0801 None 0.006 N 0.315 0.119 0.254244900254 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/N 18174 Fn3-20 9 None 0.3818 None 0.055 N 0.467 0.077 0.154104182512 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94401E-04 None 0 0 0 0 0
K/N 18174 Fn3-20 9 None 0.3818 None 0.055 N 0.467 0.077 0.154104182512 gnomAD-4.0.0 1.24062E-06 None None None None N None 0 0 None 0 2.23654E-05 None 0 0 8.48228E-07 0 0
E/K 18280 Fn3-21 9 rs904716065 0.1821 None 0.939 N 0.588 0.196 0.324161360171 gnomAD-4.0.0 1.42187E-06 None None None None N None 0 0 None 0 0 None 0 0 1.84541E-06 0 0
K/Q 18793 Fn3-24 10 None 0.1273 None 1.0 N 0.715 0.264 0.28722502521 gnomAD-4.0.0 7.12718E-07 None None None None N None 0 0 None 0 0 None 0 0 9.21255E-07 0 0
K/R 18793 Fn3-24 10 rs570125605 0.0802 -0.296 0.999 N 0.561 0.205 0.431379191433 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94099E-04 None 0 0 0 0 0
K/R 18793 Fn3-24 10 rs570125605 0.0802 -0.296 0.999 N 0.561 0.205 0.431379191433 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
K/R 18793 Fn3-24 10 rs570125605 0.0802 -0.296 0.999 N 0.561 0.205 0.431379191433 gnomAD-4.0.0 6.57134E-06 None None None None N None 0 0 None 0 1.94553E-04 None 0 0 0 0 0
T/A 18892 Fn3-25 9 rs780258242 0.0888 -0.8 0.898 N 0.494 0.23 0.255777322467 gnomAD-2.1.1 4.52E-06 None None None None N None 0 0 None 0 0 None 3.99E-05 None 0 0 0
T/A 18892 Fn3-25 9 rs780258242 0.0888 -0.8 0.898 N 0.494 0.23 0.255777322467 gnomAD-4.0.0 7.00877E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.24076E-05 0
T/I 18892 Fn3-25 9 None 0.16 None 0.997 N 0.818 0.417 0.37479162749 gnomAD-4.0.0 6.99567E-07 None None None None N None 0 0 None 0 0 None 0 0 9.124E-07 0 0
T/K 18892 Fn3-25 9 rs1405285641 0.2993 None 0.993 N 0.743 0.365 0.341934017632 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.57E-05 0 0 0 None 0 0 0 0 0
T/K 18892 Fn3-25 9 rs1405285641 0.2993 None 0.993 N 0.743 0.365 0.341934017632 gnomAD-4.0.0 1.26472E-06 None None None None N None 0 1.82375E-05 None 0 0 None 0 0 0 0 1.63848E-05
T/P 18892 Fn3-25 9 rs780258242 0.6969 -0.362 0.997 N 0.822 0.422 0.375326005269 gnomAD-2.1.1 1.81E-05 None None None None N None 2.70709E-04 0 None 0 0 None 0 None 0 0 0
T/P 18892 Fn3-25 9 rs780258242 0.6969 -0.362 0.997 N 0.822 0.422 0.375326005269 gnomAD-3.1.2 1.32E-05 None None None None N None 0 1.31337E-04 0 0 0 None 0 0 0 0 0
T/P 18892 Fn3-25 9 rs780258242 0.6969 -0.362 0.997 N 0.822 0.422 0.375326005269 gnomAD-4.0.0 6.33354E-06 None None None None N None 6.80087E-05 7.4118E-05 None 0 0 None 0 0 0 0 1.6408E-05
T/R 18892 Fn3-25 9 rs1405285641 0.2567 -0.147 0.993 N 0.82 0.375 0.403752378121 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
T/R 18892 Fn3-25 9 rs1405285641 0.2567 -0.147 0.993 N 0.82 0.375 0.403752378121 gnomAD-4.0.0 5.59653E-06 None None None None N None 0 0 None 0 0 None 0 0 7.2992E-06 0 0
K/Q 18996 Fn3-26 9 rs541709149 0.1665 -0.061 0.284 N 0.271 0.095 0.162503812791 gnomAD-2.1.1 2.1E-05 None None None None N None 0 0 None 0 0 None 1.80297E-04 None 0 0 0
K/Q 18996 Fn3-26 9 rs541709149 0.1665 -0.061 0.284 N 0.271 0.095 0.162503812791 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
K/Q 18996 Fn3-26 9 rs541709149 0.1665 -0.061 0.284 N 0.271 0.095 0.162503812791 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
K/Q 18996 Fn3-26 9 rs541709149 0.1665 -0.061 0.284 N 0.271 0.095 0.162503812791 gnomAD-4.0.0 8.72732E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.47119E-04 1.61103E-05
K/R 18996 Fn3-26 9 rs1002471047 0.0788 None 0.865 N 0.484 0.176 0.271763555656 gnomAD-4.0.0 9.6924E-06 None None None None N None 0 0 None 0 0 None 0 0 1.72604E-05 0 0
L/P 19192 Fn3-27 10 rs1338687639 0.6472 None 0.295 N 0.599 0.213 0.576807342058 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/P 19192 Fn3-27 10 rs1338687639 0.6472 None 0.295 N 0.599 0.213 0.576807342058 gnomAD-4.0.0 1.86659E-06 None None None None I None 0 0 None 0 0 None 0 0 2.54908E-06 0 0
L/V 19192 Fn3-27 10 None 0.0653 None 0.001 N 0.218 0.064 0.342400092842 gnomAD-4.0.0 4.82498E-06 None None None None I None 0 0 None 0 0 None 0 0 8.64788E-06 0 0
E/A 19292 Fn3-28 9 rs1225953212 0.1329 -0.555 0.625 N 0.476 0.141 0.300110245524 gnomAD-2.1.1 4.05E-06 None None None None N None 0 2.92E-05 None 0 0 None 0 None 0 0 0
E/A 19292 Fn3-28 9 rs1225953212 0.1329 -0.555 0.625 N 0.476 0.141 0.300110245524 gnomAD-4.0.0 1.59757E-06 None None None None N None 0 2.29632E-05 None 0 0 None 0 0 0 0 0
I/V 19587 Fn3-30 9 rs916546048 0.0574 None None N 0.159 0.053 0.163833314356 gnomAD-4.0.0 1.36952E-06 None None None None N None 2.99383E-05 0 None 0 0 None 0 0 8.99666E-07 0 0
E/Q 19688 Fn3-31 9 None 0.1259 None 0.31 N 0.269 0.185 0.282179105231 gnomAD-4.0.0 1.59269E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86002E-06 0 0
E/K 19885 Fn3-32 9 rs777362856 0.1027 0.57 0.002 N 0.152 0.137 0.191931220699 gnomAD-2.1.1 1.23E-05 None None None None N None 0 0 None 0 0 None 6.6E-05 None 4.68E-05 0 0
E/K 19885 Fn3-32 9 rs777362856 0.1027 0.57 0.002 N 0.152 0.137 0.191931220699 gnomAD-4.0.0 5.4811E-06 None None None None N None 0 0 None 0 0 None 0 1.73792E-04 0 8.14143E-05 0
H/Y 19985 Fn3-33 9 None 0.2478 None 0.014 N 0.283 0.326 0.218112801441 gnomAD-4.0.0 1.59394E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8608E-06 0 0
N/H 20180 Fn3-34 10 rs1030296243 0.0665 -0.787 0.003 N 0.317 0.079 0.0611884634855 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/H 20180 Fn3-34 10 rs1030296243 0.0665 -0.787 0.003 N 0.317 0.079 0.0611884634855 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/H 20180 Fn3-34 10 rs1030296243 0.0665 -0.787 0.003 N 0.317 0.079 0.0611884634855 gnomAD-4.0.0 3.71919E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39112E-06 2.19626E-05 0
V/L 20279 Fn3-35 9 rs2050067416 0.1182 None 0.27 N 0.393 0.107 0.241664281697 gnomAD-4.0.0 6.85258E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00911E-07 0 0
V/M 20279 Fn3-35 9 None 0.0905 None 0.863 N 0.505 0.188 0.318828661733 gnomAD-4.0.0 3.42629E-06 None None None None N None 0 0 None 0 0 None 0 0 4.50455E-06 0 0
K/E 20379 Fn3-36 9 rs775620011 0.6714 0.298 0.999 N 0.631 0.357 0.370051654043 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.29E-05 None 0 0 0
K/E 20379 Fn3-36 9 rs775620011 0.6714 0.298 0.999 N 0.631 0.357 0.370051654043 gnomAD-4.0.0 1.59411E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43682E-05 0
K/T 20379 Fn3-36 9 None 0.54 None 1.0 N 0.8 0.382 0.412715890961 gnomAD-4.0.0 1.59412E-06 None None None None N None 0 2.29158E-05 None 0 0 None 0 0 0 0 0
K/E 20872 Fn3-39 9 None 0.1792 None 0.989 N 0.523 0.356 0.339555952218 gnomAD-4.0.0 6.85142E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15947E-05 0
K/I 20872 Fn3-39 9 None 0.3922 None 0.999 N 0.842 0.409 0.603539076606 gnomAD-4.0.0 3.1928E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86582E-05 0
K/Q 20872 Fn3-39 9 rs759762547 0.1027 0.055 0.997 N 0.658 0.346 0.221019684889 gnomAD-2.1.1 8.1E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
K/Q 20872 Fn3-39 9 rs759762547 0.1027 0.055 0.997 N 0.658 0.346 0.221019684889 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/Q 20872 Fn3-39 9 rs759762547 0.1027 0.055 0.997 N 0.658 0.346 0.221019684889 gnomAD-4.0.0 8.06644E-06 None None None None N None 0 0 None 0 0 None 0 0 1.10208E-05 0 0
E/Q 20971 Fn3-40 9 None 0.1635 None 0.864 N 0.702 0.187 0.328486982098 gnomAD-4.0.0 5.47497E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19673E-06 0 0
K/E 21274 Fn3-42 9 rs886042547 0.1208 None 0.001 N 0.205 0.115 0.199424873507 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
K/T 21274 Fn3-42 9 None 0.0777 None 0.003 N 0.367 0.155 0.241078983079 gnomAD-4.0.0 1.59787E-06 None None None None N None 0 0 None 0 2.79814E-05 None 0 0 0 0 0
R/Q 21667 Fn3-45 9 rs758072872 0.1052 0.091 0.082 N 0.189 0.13 0.115124310173 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 6.56E-05 0 0 1.94175E-04 None 0 0 0 0 0
R/Q 21667 Fn3-45 9 rs758072872 0.1052 0.091 0.082 N 0.189 0.13 0.115124310173 gnomAD-4.0.0 8.68252E-06 None None None None N None 1.33372E-05 1.66795E-05 None 3.38158E-05 2.23944E-05 None 0 3.30797E-04 4.24114E-06 3.29765E-05 0
E/A 21765 Fn3-46 9 rs1430045391 0.3036 -0.645 0.999 N 0.751 0.353 0.406120066682 gnomAD-2.1.1 4.49E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.85048E-04
E/A 21765 Fn3-46 9 rs1430045391 0.3036 -0.645 0.999 N 0.751 0.353 0.406120066682 gnomAD-4.0.0 6.98304E-06 None None None None N None 0 0 None 0 0 None 0 0 7.31498E-06 0 3.38352E-05
V/L 22063 Fn3-48 9 rs768057735 0.1688 -0.192 0.489 N 0.437 0.104 None gnomAD-2.1.1 6.49E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.43699E-04 0
V/L 22063 Fn3-48 9 rs768057735 0.1688 -0.192 0.489 N 0.437 0.104 None gnomAD-3.1.2 3.95E-05 None None None None N None 0 0 0 0 0 None 0 0 8.82E-05 0 0
V/L 22063 Fn3-48 9 rs768057735 0.1688 -0.192 0.489 N 0.437 0.104 None gnomAD-4.0.0 5.51877E-05 None None None None N None 1.33629E-05 0 None 0 0 None 0 1.64962E-04 7.20675E-05 1.09893E-05 1.60205E-05
K/I 22164 Fn3-49 9 rs371081043 0.6712 0.561 1.0 D 0.911 0.442 None gnomAD-2.1.1 6.48E-05 None None None None N None 6.97837E-04 0 None 0 0 None 0 None 0 0 1.485E-04
K/I 22164 Fn3-49 9 rs371081043 0.6712 0.561 1.0 D 0.911 0.442 None gnomAD-3.1.2 1.51296E-04 None None None None N None 5.31093E-04 0 0 0 0 None 0 0 0 0 4.78927E-04
K/I 22164 Fn3-49 9 rs371081043 0.6712 0.561 1.0 D 0.911 0.442 None gnomAD-4.0.0 3.0608E-05 None None None None N None 6.18496E-04 0 None 0 0 None 0 0 0 0 4.8459E-05
K/Q 22164 Fn3-49 9 None 0.2983 None 1.0 N 0.714 0.338 0.218845423259 gnomAD-4.0.0 1.62479E-06 None None None None N None 0 0 None 0 0 None 0 0 2.91267E-06 0 0
K/T 22164 Fn3-49 9 rs371081043 0.4587 -0.663 1.0 N 0.838 0.41 0.388334884743 gnomAD-2.1.1 1.3E-05 None None None None N None 0 9.47E-05 None 0 0 None 0 None 0 0 0
K/T 22164 Fn3-49 9 rs371081043 0.4587 -0.663 1.0 N 0.838 0.41 0.388334884743 gnomAD-4.0.0 2.07058E-06 None None None None N None 0 7.04358E-05 None 0 0 None 0 0 0 0 0
N/S 22751 Fn3-53 9 rs761226149 0.0647 -0.288 None N 0.109 0.102 0.146414634003 gnomAD-2.1.1 1.22E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.68E-05 0
N/S 22751 Fn3-53 9 rs761226149 0.0647 -0.288 None N 0.109 0.102 0.146414634003 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
N/S 22751 Fn3-53 9 rs761226149 0.0647 -0.288 None N 0.109 0.102 0.146414634003 gnomAD-4.0.0 9.92853E-06 None None None None I None 1.33743E-05 1.67347E-05 None 0 0 None 0 0 1.1026E-05 0 1.60375E-05
E/K 22849 Fn3-54 9 None 0.1619 None 0.014 N 0.203 0.156 0.232513804876 gnomAD-4.0.0 1.3967E-06 None None None None N None 0 0 None 0 0 None 0 0 9.10584E-07 1.23864E-05 0
E/D 23147 Fn3-56 9 rs1173953424 0.1554 -0.57 0.003 N 0.153 0.113 0.198526703765 gnomAD-2.1.1 4.04E-06 None None None None N None 0 2.92E-05 None 0 0 None 0 None 0 0 0
E/D 23147 Fn3-56 9 rs1173953424 0.1554 -0.57 0.003 N 0.153 0.113 0.198526703765 gnomAD-4.0.0 1.59336E-06 None None None None N None 0 2.29221E-05 None 0 0 None 0 0 0 0 0
E/G 23147 Fn3-56 9 rs1396597790 0.2202 -1.026 0.722 N 0.657 0.302 0.424073947737 gnomAD-2.1.1 4.05E-06 None None None None N None 0 2.92E-05 None 0 0 None 0 None 0 0 0
E/G 23147 Fn3-56 9 rs1396597790 0.2202 -1.026 0.722 N 0.657 0.302 0.424073947737 gnomAD-4.0.0 1.59349E-06 None None None None N None 0 2.29305E-05 None 0 0 None 0 0 0 0 0
H/P 23248 Fn3-57 9 rs1423241119 0.7919 0.889 0.065 N 0.493 0.109 0.0666544352282 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 9.42E-05 0 0 0 0
H/P 23248 Fn3-57 9 rs1423241119 0.7919 0.889 0.065 N 0.493 0.109 0.0666544352282 gnomAD-4.0.0 1.91718E-06 None None None None I None 0 0 None 0 0 None 1.61655E-05 0 1.72E-06 0 0
H/Q 23248 Fn3-57 9 rs774642251 0.1231 0.578 0.007 N 0.327 0.114 0.0297737177859 gnomAD-2.1.1 1.48E-05 None None None None I None 0 0 None 0 0 None 0 None 0 3.09E-05 0
H/Q 23248 Fn3-57 9 rs774642251 0.1231 0.578 0.007 N 0.327 0.114 0.0297737177859 gnomAD-4.0.0 2.12342E-06 None None None None I None 0 0 None 0 0 None 0 0 2.73985E-06 0 0
H/R 23248 Fn3-57 9 None 0.0584 None None N 0.107 0.115 0.0297737177859 gnomAD-4.0.0 7.07834E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.29675E-05 0
H/Y 23248 Fn3-57 9 rs1374089814 0.1127 1.576 0.065 N 0.449 0.054 0.149567049428 gnomAD-2.1.1 1.7E-05 None None None None I None 1.72147E-04 0 None 0 0 None 0 None 0 0 0
H/Y 23248 Fn3-57 9 rs1374089814 0.1127 1.576 0.065 N 0.449 0.054 0.149567049428 gnomAD-3.1.2 2.63E-05 None None None None I None 9.66E-05 0 0 0 0 None 0 0 0 0 0
H/Y 23248 Fn3-57 9 rs1374089814 0.1127 1.576 0.065 N 0.449 0.054 0.149567049428 gnomAD-4.0.0 6.83062E-06 None None None None I None 8.85175E-05 0 None 0 0 None 0 0 0 0 0
R/G 23443 Fn3-58 9 rs765987438 0.2862 -1.283 0.251 N 0.519 0.148 0.288352970974 gnomAD-2.1.1 7.15E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.56E-05 0
R/G 23443 Fn3-58 9 rs765987438 0.2862 -1.283 0.251 N 0.519 0.148 0.288352970974 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/G 23443 Fn3-58 9 rs765987438 0.2862 -1.283 0.251 N 0.519 0.148 0.288352970974 gnomAD-4.0.0 2.48005E-06 None None None None N None 0 0 None 0 0 None 0 0 3.3922E-06 0 0
R/Q 23443 Fn3-58 9 rs762529671 0.0785 -0.131 0.271 N 0.414 0.047 0.107399877778 gnomAD-2.1.1 3.22E-05 None None None None N None 4.13E-05 0 None 0 0 None 6.54E-05 None 0 3.91E-05 1.40568E-04
R/Q 23443 Fn3-58 9 rs762529671 0.0785 -0.131 0.271 N 0.414 0.047 0.107399877778 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
R/Q 23443 Fn3-58 9 rs762529671 0.0785 -0.131 0.271 N 0.414 0.047 0.107399877778 gnomAD-4.0.0 3.22414E-05 None None None None N None 4.00759E-05 0 None 0 0 None 7.81421E-05 0 3.30736E-05 4.3929E-05 1.60179E-05
R/W 23443 Fn3-58 9 rs765987438 0.1835 -0.227 0.984 N 0.602 0.39 0.277317399466 gnomAD-2.1.1 7.15E-06 None None None None N None 0 0 None 9.68E-05 5.14E-05 None 0 None 0 0 0
R/W 23443 Fn3-58 9 rs765987438 0.1835 -0.227 0.984 N 0.602 0.39 0.277317399466 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93874E-04 None 0 0 0 0 0
R/W 23443 Fn3-58 9 rs765987438 0.1835 -0.227 0.984 N 0.602 0.39 0.277317399466 gnomAD-4.0.0 3.10006E-06 None None None None N None 0 0 None 3.37952E-05 4.46468E-05 None 0 0 8.4805E-07 1.09813E-05 0
K/R 23735 Fn3-60 10 None 0.0727 None 0.001 N 0.36 0.16 0.227934060464 gnomAD-4.0.0 1.59311E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02792E-05
Q/P 23834 Fn3-61 9 rs757958768 0.6286 0.26 0.784 N 0.573 0.269 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
Q/P 23834 Fn3-61 9 rs757958768 0.6286 0.26 0.784 N 0.573 0.269 None gnomAD-4.0.0 2.73818E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59916E-06 0 0
V/I 23932 Fn3-62 9 rs1437243224 0.0639 None 0.001 N 0.141 0.088 0.0551355673512 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 23932 Fn3-62 9 rs1437243224 0.0639 None 0.001 N 0.141 0.088 0.0551355673512 gnomAD-4.0.0 6.57557E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47059E-05 0 0
A/D 24131 Fn3-63 10 rs1334813711 0.1575 0.028 0.003 N 0.364 0.245 0.163833314356 gnomAD-2.1.1 4.65E-06 None None None None N None 6.66E-05 0 None 0 0 None 0 None 0 0 0
A/D 24131 Fn3-63 10 rs1334813711 0.1575 0.028 0.003 N 0.364 0.245 0.163833314356 gnomAD-4.0.0 7.03795E-07 None None None None N None 3.13991E-05 0 None 0 0 None 0 0 0 0 0
A/G 24131 Fn3-63 10 None 0.1259 None 0.166 N 0.264 0.069 0.0884992946249 gnomAD-4.0.0 7.03795E-07 None None None None N None 0 0 None 0 0 None 0 0 9.14344E-07 0 0
A/P 24131 Fn3-63 10 None 0.4517 None 0.662 N 0.511 0.142 0.151104730317 gnomAD-4.0.0 2.81405E-06 None None None None N None 0 0 None 0 0 None 0 0 2.74237E-06 0 1.70648E-05
E/A 24230 Fn3-64 9 rs771181715 0.2059 None 0.805 N 0.614 0.324 0.43965937752 gnomAD-2.1.1 5.72E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.17E-05 0
E/A 24230 Fn3-64 9 rs771181715 0.2059 None 0.805 N 0.614 0.324 0.43965937752 gnomAD-4.0.0 1.87812E-06 None None None None N None 0 0 None 0 0 None 0 0 3.26631E-06 0 0
E/K 24230 Fn3-64 9 None 0.2131 None 0.944 N 0.557 0.364 0.39162414616 gnomAD-4.0.0 1.87826E-06 None None None None N None 0 0 None 0 0 None 0 0 3.26522E-06 0 0
R/C 24331 Fn3-65 9 rs376591763 0.3094 -0.561 1.0 N 0.777 0.348 None gnomAD-2.1.1 2.01E-05 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 2.67E-05 0
R/C 24331 Fn3-65 9 rs376591763 0.3094 -0.561 1.0 N 0.777 0.348 None gnomAD-3.1.2 1.32E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
R/C 24331 Fn3-65 9 rs376591763 0.3094 -0.561 1.0 N 0.777 0.348 None gnomAD-4.0.0 3.96748E-05 None None None None N None 2.6713E-05 3.33622E-05 None 0 0 None 0 0 4.49337E-05 3.2954E-05 6.40697E-05
R/H 24331 Fn3-65 9 rs755174224 0.1748 -1.24 0.385 N 0.318 0.205 None gnomAD-2.1.1 1.32321E-04 None None None None N None 0 0 None 0 1.75384E-03 None 0 None 0 2.35E-05 0
R/H 24331 Fn3-65 9 rs755174224 0.1748 -1.24 0.385 N 0.318 0.205 None gnomAD-3.1.2 5.92E-05 None None None None N None 2.41E-05 0 0 0 1.1646E-03 None 0 0 2.94E-05 0 0
R/H 24331 Fn3-65 9 rs755174224 0.1748 -1.24 0.385 N 0.318 0.205 None gnomAD-4.0.0 2.47967E-05 None None None None N None 1.33547E-05 1.66811E-05 None 0 5.58684E-04 None 0 0 1.01737E-05 0 1.60174E-05
K/N 24527 Fn3-66 9 rs763480481 0.3897 -0.255 0.954 D 0.575 0.114 0.224531998449 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
K/N 24527 Fn3-66 9 rs763480481 0.3897 -0.255 0.954 D 0.575 0.114 0.224531998449 gnomAD-4.0.0 6.84344E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99577E-07 0 0
K/T 24527 Fn3-66 9 None 0.1211 None 0.04 N 0.343 0.177 0.231873229951 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
T/I 24624 Fn3-67 9 None 0.158 None 0.998 N 0.806 0.43 0.560153176789 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/R 24817 Fn3-68 10 rs565309903 0.075 -0.094 0.235 N 0.279 0.149 0.305730143919 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/R 24817 Fn3-68 10 rs565309903 0.075 -0.094 0.235 N 0.279 0.149 0.305730143919 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
K/R 24817 Fn3-68 10 rs565309903 0.075 -0.094 0.235 N 0.279 0.149 0.305730143919 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
K/R 24817 Fn3-68 10 rs565309903 0.075 -0.094 0.235 N 0.279 0.149 0.305730143919 gnomAD-4.0.0 2.02974E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.69881E-05 3.40044E-05
V/I 24916 Fn3-69 9 rs764600357 0.0645 -0.308 None N 0.115 0.068 0.139678290688 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 0 0
V/I 24916 Fn3-69 9 rs764600357 0.0645 -0.308 None N 0.115 0.068 0.139678290688 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/A 25213 Fn3-71 10 rs1707778463 0.0857 None None N 0.071 0.052 0.191931220699 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
V/A 25213 Fn3-71 10 rs1707778463 0.0857 None None N 0.071 0.052 0.191931220699 gnomAD-4.0.0 6.57687E-06 None None None None N None 0 6.55652E-05 None 0 0 None 0 0 0 0 0
V/F 25213 Fn3-71 10 rs72646901 0.1175 -0.653 0.171 N 0.587 0.036 0.600746198033 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
V/F 25213 Fn3-71 10 rs72646901 0.1175 -0.653 0.171 N 0.587 0.036 0.600746198033 gnomAD-4.0.0 6.15967E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19672E-06 0 1.65761E-05
V/I 25213 Fn3-71 10 rs72646901 0.0714 None None N 0.129 0.095 0.307332253619 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 25213 Fn3-71 10 rs72646901 0.0714 None None N 0.129 0.095 0.307332253619 gnomAD-4.0.0 1.23979E-06 None None None None N None 0 0 None 0 0 None 0 0 1.6955E-06 0 0
E/K 25312 Fn3-72 9 rs770655678 0.1572 0.368 0.999 N 0.628 0.39 0.287603790349 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
E/K 25312 Fn3-72 9 rs770655678 0.1572 0.368 0.999 N 0.628 0.39 0.287603790349 gnomAD-4.0.0 2.05303E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69874E-06 0 0
K/E 25413 Fn3-73 9 None 0.2691 None 0.001 N 0.335 0.178 0.257786959452 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/R 25413 Fn3-73 9 rs367696053 0.0653 -0.074 0.001 N 0.206 0.079 None gnomAD-2.1.1 8.06E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 8.9E-06 0
K/R 25413 Fn3-73 9 rs367696053 0.0653 -0.074 0.001 N 0.206 0.079 None gnomAD-4.0.0 2.05305E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69873E-06 0 0
K/R 25609 Fn3-74 9 None 0.0727 None None N 0.193 0.067 0.162503812791 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 25706 Fn3-75 9 rs1707111978 0.1049 None 0.001 N 0.152 0.116 0.132336055621 gnomAD-4.0.0 1.59225E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02645E-05
K/E 25899 Fn3-76 10 rs1466717136 0.2015 None 0.892 N 0.571 0.245 0.261217442401 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/E 25899 Fn3-76 10 rs1466717136 0.2015 None 0.892 N 0.571 0.245 0.261217442401 gnomAD-4.0.0 3.84574E-06 None None None None N None 1.69193E-05 0 None 0 0 None 0 0 4.78842E-06 0 0
K/I 25899 Fn3-76 10 rs750227997 0.1614 0.42 0.935 N 0.704 0.288 0.426787303895 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
K/I 25899 Fn3-76 10 rs750227997 0.1614 0.42 0.935 N 0.704 0.288 0.426787303895 gnomAD-4.0.0 3.1848E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71948E-06 0 0
F/L 25998 Fn3-77 9 None 0.7777 None 0.999 N 0.535 0.443 0.243398259712 gnomAD-4.0.0 1.59185E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
E/K 26096 Fn3-78 9 rs370515843 0.1454 -0.354 0.959 N 0.419 0.238 None gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
E/K 26096 Fn3-78 9 rs370515843 0.1454 -0.354 0.959 N 0.419 0.238 None gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
E/K 26096 Fn3-78 9 rs370515843 0.1454 -0.354 0.959 N 0.419 0.238 None gnomAD-4.0.0 5.12656E-06 None None None None N None 6.7714E-05 0 None 0 0 None 0 0 0 0 0
E/Q 26394 Fn3-80 9 rs144788732 0.2214 -0.139 1.0 N 0.659 0.199 None gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.93424E-04 None 0 0 0 0 0
E/Q 26394 Fn3-80 9 rs144788732 0.2214 -0.139 1.0 N 0.659 0.199 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
E/Q 26394 Fn3-80 9 rs144788732 0.2214 -0.139 1.0 N 0.659 0.199 None gnomAD-4.0.0 1.02504E-05 None None None None I None 0 0 None 0 1.94156E-04 None 0 0 0 0 0
H/R 26495 Fn3-81 9 None 0.0936 None 0.521 N 0.408 0.274 0.141422826196 gnomAD-4.0.0 1.5932E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85894E-06 0 0
A/T 26691 Fn3-82 9 None 0.0578 None None N 0.099 0.096 0.0297737177859 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/L 26981 Fn3-84 10 None 0.1743 None 0.251 D 0.559 0.127 0.400613892164 gnomAD-4.0.0 1.36867E-06 None None None None N None 0 0 None 3.82936E-05 0 None 0 0 8.99567E-07 0 0
R/Q 26981 Fn3-84 10 rs768308408 0.0881 -0.477 0.271 N 0.517 0.088 0.119812018005 gnomAD-2.1.1 3.58E-05 None None None None N None 0 5.66E-05 None 0 5.14E-05 None 6.54E-05 None 0 2.35E-05 2.81215E-04
R/Q 26981 Fn3-84 10 rs768308408 0.0881 -0.477 0.271 N 0.517 0.088 0.119812018005 gnomAD-3.1.2 4.6E-05 None None None None N None 0 3.27611E-04 0 0 0 None 0 0 2.94E-05 0 0
R/Q 26981 Fn3-84 10 rs768308408 0.0881 -0.477 0.271 N 0.517 0.088 0.119812018005 gnomAD-4.0.0 9.48326E-05 None None None None N None 1.33543E-05 1.16717E-04 None 0 0 None 0 0 1.00877E-04 2.08709E-04 1.12108E-04
R/W 26981 Fn3-84 10 rs779878975 0.2086 -0.477 0.984 N 0.657 0.267 0.313818047136 gnomAD-2.1.1 2.82E-05 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 3.57E-05 1.66058E-04
R/W 26981 Fn3-84 10 rs779878975 0.2086 -0.477 0.984 N 0.657 0.267 0.313818047136 gnomAD-3.1.2 3.29E-05 None None None None N None 4.83E-05 0 0 0 1.93199E-04 None 0 0 2.94E-05 0 0
R/W 26981 Fn3-84 10 rs779878975 0.2086 -0.477 0.984 N 0.657 0.267 0.313818047136 gnomAD-4.0.0 3.28501E-05 None None None None N None 2.67087E-05 1.16733E-04 None 0 2.23095E-05 None 0 0 3.4756E-05 0 3.20297E-05
E/K 27178 Fn3-86 9 rs397517721 0.2794 None 0.977 N 0.615 0.33 0.318540980066 gnomAD-3.1.2 1.32E-05 None None None None N None 0 1.31027E-04 0 0 0 None 0 0 0 0 0
E/K 27178 Fn3-86 9 rs397517721 0.2794 None 0.977 N 0.615 0.33 0.318540980066 gnomAD-4.0.0 1.31518E-05 None None None None N None 0 1.31027E-04 None 0 0 None 0 0 0 0 0
K/T 27378 Fn3-87 10 rs886055240 0.0881 -0.315 0.549 N 0.504 0.089 0.280987212366 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
K/T 27378 Fn3-87 10 rs886055240 0.0881 -0.315 0.549 N 0.504 0.089 0.280987212366 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/T 27378 Fn3-87 10 rs886055240 0.0881 -0.315 0.549 N 0.504 0.089 0.280987212366 gnomAD-4.0.0 4.33821E-06 None None None None N None 0 0 None 0 0 None 0 0 5.08587E-06 0 1.60123E-05
E/D 27477 Fn3-88 9 None 0.1604 None 0.822 N 0.51 0.165 0.32980341726 gnomAD-4.0.0 1.59118E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
E/G 27477 Fn3-88 9 rs1184828155 0.3034 -1.173 0.014 N 0.4 0.281 0.27132560031 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/G 27477 Fn3-88 9 rs1184828155 0.3034 -1.173 0.014 N 0.4 0.281 0.27132560031 gnomAD-4.0.0 1.59122E-06 None None None None I None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
K/E 27578 Fn3-89 9 rs368850871 0.4341 0.252 0.999 N 0.617 0.325 None gnomAD-2.1.1 3.22E-05 None None None None N None 0 0 None 5.97848E-04 0 None 3.27E-05 None 0 8.92E-06 0
K/E 27578 Fn3-89 9 rs368850871 0.4341 0.252 0.999 N 0.617 0.325 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 1.1534E-03 0 None 0 0 0 0 0
K/E 27578 Fn3-89 9 rs368850871 0.4341 0.252 0.999 N 0.617 0.325 None gnomAD-4.0.0 1.73541E-05 None None None None N None 0 0 None 6.75767E-04 0 None 0 0 8.47652E-07 1.09791E-05 9.6083E-05
T/I 27774 Fn3-90 9 rs1704174371 0.0858 None 0.029 N 0.497 0.092 0.29132392195 gnomAD-4.0.0 6.84552E-07 None None None None N None 0 2.24034E-05 None 0 0 None 0 0 0 0 0
T/N 27774 Fn3-90 9 None 0.083 None None N 0.257 0.085 0.270001397563 gnomAD-4.0.0 1.3691E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79938E-06 0 0
T/S 27774 Fn3-90 9 None 0.0843 None 0.001 N 0.178 0.116 0.167679373172 gnomAD-4.0.0 6.84552E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9969E-07 0 0
T/I 27871 Fn3-91 9 rs746421338 0.1845 0.353 0.01 N 0.305 0.179 None gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 2.87853E-04 0 0
T/I 27871 Fn3-91 9 rs746421338 0.1845 0.353 0.01 N 0.305 0.179 None gnomAD-4.0.0 6.16812E-06 None None None None N None 0 0 None 0 0 None 3.75488E-05 3.48068E-04 4.49987E-06 0 0
T/N 27871 Fn3-91 9 None 0.1502 None 0.716 N 0.453 0.187 0.351180957027 gnomAD-4.0.0 6.85346E-07 None None None None N None 3.00282E-05 0 None 0 0 None 0 0 0 0 0
R/C 28063 Fn3-92 9 rs539595292 0.0856 -0.098 0.964 N 0.408 0.148 0.424908009808 gnomAD-2.1.1 2.51E-05 None None None None N None 4.13E-05 8.51E-05 None 0 0 None 0 None 0 2.35E-05 0
R/C 28063 Fn3-92 9 rs539595292 0.0856 -0.098 0.964 N 0.408 0.148 0.424908009808 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
R/C 28063 Fn3-92 9 rs539595292 0.0856 -0.098 0.964 N 0.408 0.148 0.424908009808 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
R/C 28063 Fn3-92 9 rs539595292 0.0856 -0.098 0.964 N 0.408 0.148 0.424908009808 gnomAD-4.0.0 1.42571E-05 None None None None N None 1.33312E-05 5.002E-05 None 0 0 None 0 0 1.44132E-05 1.0981E-05 1.60149E-05
R/H 28063 Fn3-92 9 rs570847832 0.0608 -0.708 None N 0.175 0.179 None gnomAD-2.1.1 8.47E-05 None None None None N None 1.29266E-04 0 None 0 5.61E-05 None 2.61626E-04 None 0 8.92E-05 0
R/H 28063 Fn3-92 9 rs570847832 0.0608 -0.708 None N 0.175 0.179 None gnomAD-3.1.2 3.29E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 2.94E-05 0 4.78927E-04
R/H 28063 Fn3-92 9 rs570847832 0.0608 -0.708 None N 0.175 0.179 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
R/H 28063 Fn3-92 9 rs570847832 0.0608 -0.708 None N 0.175 0.179 None gnomAD-4.0.0 6.13723E-05 None None None None N None 3.99979E-05 0 None 0 0 None 0 0 7.03769E-05 8.78503E-05 8.00897E-05
K/E 28162 Fn3-93 9 rs775599688 0.1285 None 0.001 N 0.233 0.096 0.236278675362 gnomAD-4.0.0 1.60188E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87652E-06 0 0
K/T 28162 Fn3-93 9 None 0.1213 None 0.491 N 0.417 0.131 0.262662153117 gnomAD-4.0.0 1.08029E-05 None None None None N None 0 0 None 0 0 None 0 0 1.18125E-05 0 0
E/D 28260 Fn3-94 9 rs370547473 0.2008 -0.905 0.071 N 0.163 0.122 0.199424873507 gnomAD-2.1.1 4.02E-05 None None None None N None 0 2.31777E-04 None 0 0 None 0 None 0 8.9E-06 1.65782E-04
E/D 28260 Fn3-94 9 rs370547473 0.2008 -0.905 0.071 N 0.163 0.122 0.199424873507 gnomAD-3.1.2 9.2E-05 None None None None N None 2.41E-05 8.52124E-04 0 0 0 None 0 0 0 0 0
E/D 28260 Fn3-94 9 rs370547473 0.2008 -0.905 0.071 N 0.163 0.122 0.199424873507 gnomAD-4.0.0 1.79707E-05 None None None None N None 1.33469E-05 3.66801E-04 None 0 0 None 0 0 3.39036E-06 0 3.20215E-05
E/A 28558 Fn3-96 9 None 0.239 None 0.989 N 0.637 0.457 0.376216005999 gnomAD-4.0.0 1.59197E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85865E-06 0 0
K/I 28659 Fn3-97 9 None 0.406 None 0.188 N 0.631 0.129 0.452072420954 gnomAD-4.0.0 2.73707E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.63779E-05 0
K/R 28659 Fn3-97 9 rs200724395 0.071 None None N 0.307 0.039 0.159798565429 gnomAD-4.0.0 6.1584E-06 None None None None N None 0 0 None 0 1.76411E-04 None 0 0 1.79909E-06 0 0
K/T 28659 Fn3-97 9 rs200724395 0.255 -0.322 None N 0.346 0.058 None gnomAD-2.1.1 3.62E-05 None None None None N None 0 0 None 0 0 None 0 None 0 7.12E-05 1.66334E-04
K/T 28659 Fn3-97 9 rs200724395 0.255 -0.322 None N 0.346 0.058 None gnomAD-3.1.2 5.92E-05 None None None None N None 0 0 0 0 0 None 0 0 1.32345E-04 0 0
K/T 28659 Fn3-97 9 rs200724395 0.255 -0.322 None N 0.346 0.058 None gnomAD-4.0.0 2.91304E-05 None None None None N None 0 0 None 0 0 None 0 0 3.81459E-05 0 3.20246E-05
T/I 28853 Fn3-98 9 rs769730805 0.0652 -0.097 None N 0.211 0.095 0.104622674875 gnomAD-2.1.1 8.05E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
T/I 28853 Fn3-98 9 rs769730805 0.0652 -0.097 None N 0.211 0.095 0.104622674875 gnomAD-4.0.0 1.36844E-06 None None None None N None 0 4.47227E-05 None 0 0 None 0 0 0 0 0
T/S 28853 Fn3-98 9 None 0.076 None None N 0.094 0.08 0.0551355673512 gnomAD-4.0.0 6.8422E-07 None None None None N None 2.98739E-05 0 None 0 0 None 0 0 0 0 0
G/E 28950 Fn3-99 9 rs778672490 0.353 -0.032 1.0 N 0.862 0.437 0.337378238328 gnomAD-2.1.1 1.22E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.8E-05 1.67673E-04
G/E 28950 Fn3-99 9 rs778672490 0.353 -0.032 1.0 N 0.862 0.437 0.337378238328 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
G/E 28950 Fn3-99 9 rs778672490 0.353 -0.032 1.0 N 0.862 0.437 0.337378238328 gnomAD-4.0.0 1.2408E-05 None None None None N None 0 0 None 0 0 None 0 0 1.6957E-05 0 0
G/R 28950 Fn3-99 9 rs886044180 0.4756 -0.383 1.0 N 0.849 0.395 0.414798848334 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
G/R 28950 Fn3-99 9 rs886044180 0.4756 -0.383 1.0 N 0.849 0.395 0.414798848334 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/R 28950 Fn3-99 9 rs886044180 0.4756 -0.383 1.0 N 0.849 0.395 0.414798848334 gnomAD-4.0.0 4.06001E-06 None None None None N None 3.49528E-05 0 None 0 0 None 0 0 2.40987E-06 0 0
V/F 29146 Fn3-100 10 rs794729520 0.116 None 0.317 N 0.626 0.113 0.650379344195 gnomAD-3.1.2 1.31E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
V/F 29146 Fn3-100 10 rs794729520 0.116 None 0.317 N 0.626 0.113 0.650379344195 gnomAD-4.0.0 1.31428E-05 None None None None I None 4.82532E-05 0 None 0 0 None 0 0 0 0 0
W/C 29245 Fn3-101 9 rs745430117 0.6431 0.292 0.99 N 0.615 0.34 0.516491959214 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
W/C 29245 Fn3-101 9 rs745430117 0.6431 0.292 0.99 N 0.615 0.34 0.516491959214 gnomAD-4.0.0 1.59116E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85783E-06 0 0
W/G 29245 Fn3-101 9 None 0.4656 None 0.549 N 0.558 0.26 0.442363741745 gnomAD-4.0.0 4.80129E-06 None None None None I None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
W/R 29245 Fn3-101 9 rs771722716 0.6069 0.274 0.009 N 0.391 0.164 0.137902524267 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
W/R 29245 Fn3-101 9 rs771722716 0.6069 0.274 0.009 N 0.391 0.164 0.137902524267 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/C 29343 Fn3-102 9 None 0.15 None 1.0 N 0.809 0.38 0.672407775526 gnomAD-4.0.0 4.79039E-06 None None None None N None 0 0 None 0 1.01087E-04 None 0 0 2.69855E-06 0 0
R/H 29343 Fn3-102 9 rs73036368 0.0908 -1.616 0.999 N 0.611 0.29 None gnomAD-2.1.1 1.50565E-04 None None None None N None 1.24172E-03 2.84E-05 None 0 0 None 6.55E-05 None 0 7.07E-05 0
R/H 29343 Fn3-102 9 rs73036368 0.0908 -1.616 0.999 N 0.611 0.29 None gnomAD-3.1.2 4.53422E-04 None None None None N None 1.32664E-03 6.55E-05 0 0 0 None 0 0 1.91098E-04 0 0
R/H 29343 Fn3-102 9 rs73036368 0.0908 -1.616 0.999 N 0.611 0.29 None 1000 genomes 9.98403E-04 None None None None N None 3.8E-03 0 None None 0 0 None None None 0 None
R/H 29343 Fn3-102 9 rs73036368 0.0908 -1.616 0.999 N 0.611 0.29 None gnomAD-4.0.0 1.81584E-04 None None None None N None 1.55896E-03 3.33444E-05 None 0 0 None 0 0 1.33928E-04 3.29554E-05 2.08107E-04
R/P 29343 Fn3-102 9 None 0.9335 None 0.996 N 0.831 0.373 0.524843318063 gnomAD-4.0.0 6.15898E-06 None None None None N None 0 0 None 0 0 None 0 0 8.09561E-06 0 0
E/K 29542 Fn3-103 10 None 0.177 None 0.454 N 0.485 0.173 0.231231049324 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 29641 Fn3-104 9 rs772380405 0.1661 0.103 0.122 N 0.235 0.166 0.269558022972 gnomAD-2.1.1 1.26E-05 None None None None N None 0 9.09E-05 None 0 0 None 0 None 0 0 0
E/K 29641 Fn3-104 9 rs772380405 0.1661 0.103 0.122 N 0.235 0.166 0.269558022972 gnomAD-4.0.0 2.75391E-06 None None None None N None 0 6.92841E-05 None 0 0 None 0 0 9.02389E-07 0 0
R/G 29742 Fn3-105 9 None 0.3653 None 0.549 N 0.535 0.166 0.463586170655 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/L 30038 Fn3-107 9 rs1035231480 0.079 None 0.001 N 0.243 0.088 0.375861065471 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.93751E-06 0 0
R/Q 30233 Fn3-108 10 rs757438306 0.0979 -0.523 0.275 N 0.337 0.078 0.110078149338 gnomAD-2.1.1 3.58E-05 None None None None N None 0 2.83E-05 None 0 2.05128E-04 None 0 None 4.01E-05 3.14E-05 0
R/Q 30233 Fn3-108 10 rs757438306 0.0979 -0.523 0.275 N 0.337 0.078 0.110078149338 gnomAD-3.1.2 1.97E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 0 0
R/Q 30233 Fn3-108 10 rs757438306 0.0979 -0.523 0.275 N 0.337 0.078 0.110078149338 gnomAD-4.0.0 1.54951E-05 None None None None N None 2.67037E-05 3.33634E-05 None 0 1.11418E-04 None 3.12647E-05 0 9.32442E-06 0 4.80477E-05
V/I 30332 Fn3-109 9 None 0.0741 None 0.997 N 0.481 0.175 0.593798965771 gnomAD-4.0.0 1.36843E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79899E-06 0 0
D/G 30430 Fn3-110 9 None 0.4247 None 0.92 N 0.443 0.167 0.201204373187 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
R/I 30628 Fn3-111 10 rs780476250 0.2244 0.4 1.0 N 0.787 0.361 0.494700469353 gnomAD-2.1.1 4.38E-06 None None None None N None 0 3.28E-05 None 0 0 None 0 None 0 0 0
R/I 30628 Fn3-111 10 rs780476250 0.2244 0.4 1.0 N 0.787 0.361 0.494700469353 gnomAD-4.0.0 1.39727E-06 None None None None N None 0 4.92756E-05 None 0 0 None 0 0 0 0 0
R/K 30628 Fn3-111 10 rs780476250 0.1103 -0.086 0.997 N 0.529 0.22 None gnomAD-2.1.1 1.32E-05 None None None None N None 6.6E-05 0 None 0 0 None 7.91E-05 None 0 0 0
R/K 30628 Fn3-111 10 rs780476250 0.1103 -0.086 0.997 N 0.529 0.22 None gnomAD-3.1.2 3.94E-05 None None None None N None 1.44781E-04 0 0 0 0 None 0 0 0 0 0
R/K 30628 Fn3-111 10 rs780476250 0.1103 -0.086 0.997 N 0.529 0.22 None gnomAD-4.0.0 1.3892E-05 None None None None N None 2.30659E-04 0 None 0 0 None 0 0 0 2.33242E-05 4.91884E-05
R/S 30628 Fn3-111 10 rs144922355 0.3705 -0.428 1.0 N 0.766 0.339 0.257786959452 gnomAD-2.1.1 1.65515E-03 None None None None N None 1.75468E-02 3.40136E-04 None 0 0 None 7.58E-05 None 0 1.63E-05 3.00842E-04
R/S 30628 Fn3-111 10 rs144922355 0.3705 -0.428 1.0 N 0.766 0.339 0.257786959452 gnomAD-3.1.2 4.54109E-03 None None None None N None 1.62225E-02 6.55308E-04 0 0 0 None 0 0 1.47E-05 0 3.82044E-03
R/S 30628 Fn3-111 10 rs144922355 0.3705 -0.428 1.0 N 0.766 0.339 0.257786959452 1000 genomes 3.99361E-03 None None None None N None 1.51E-02 0 None None 0 0 None None None 0 None
R/S 30628 Fn3-111 10 rs144922355 0.3705 -0.428 1.0 N 0.766 0.339 0.257786959452 gnomAD-4.0.0 8.43089E-04 None None None None N None 1.66265E-02 4.92247E-04 None 0 0 None 0 3.36927E-04 6.85964E-06 4.60872E-05 1.11122E-03
E/A 30727 Fn3-112 9 None 0.1988 None 0.896 N 0.634 0.405 0.431931272081 gnomAD-4.0.0 6.87049E-07 None None None None N None 0 0 None 0 0 None 0 0 9.03045E-07 0 0
K/N 30829 Fn3-113 9 rs764294218 0.5451 -0.262 0.978 N 0.657 0.3 0.228597637076 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
K/N 30829 Fn3-113 9 rs764294218 0.5451 -0.262 0.978 N 0.657 0.3 0.228597637076 gnomAD-4.0.0 4.77351E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57373E-06 0 0
T/A 31024 Fn3-114 9 rs887995092 0.0804 None 0.025 N 0.191 0.078 0.218845423259 gnomAD-4.0.0 5.47347E-06 None None None None N None 5.97586E-05 0 None 0 0 None 0 0 4.49727E-06 0 1.65651E-05
T/I 31024 Fn3-114 9 None 0.142 None 0.97 D 0.693 0.362 0.40032279838 gnomAD-4.0.0 1.5911E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85806E-06 0 0
D/H 31121 Fn3-115 9 rs1387694894 0.7743 0.634 1.0 N 0.845 0.406 0.317958651998 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/H 31121 Fn3-115 9 rs1387694894 0.7743 0.634 1.0 N 0.845 0.406 0.317958651998 gnomAD-4.0.0 1.59109E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
E/K 31317 Fn3-116 10 None 0.0932 None 0.008 N 0.338 0.115 0.197625483188 gnomAD-4.0.0 1.59105E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85786E-06 0 0
E/Q 31514 Fn3-118 9 rs1697413804 0.1802 None 1.0 N 0.663 0.269 0.346768085243 gnomAD-4.0.0 1.65961E-06 None None None None N None 0 0 None 0 0 None 0 0 2.9931E-06 0 0
T/N 31716 Fn3-119 9 rs879097606 0.0955 None 0.998 N 0.504 0.259 0.359557344763 gnomAD-4.0.0 1.59902E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87495E-06 0 0
T/S 31716 Fn3-119 9 None 0.085 None 0.828 N 0.476 0.142 0.228597637076 gnomAD-4.0.0 1.59929E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87578E-06 0 0
E/K 31815 Fn3-120 9 rs779953291 0.1191 -0.442 0.37 N 0.48 0.225 0.297375071883 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
E/K 31815 Fn3-120 9 rs779953291 0.1191 -0.442 0.37 N 0.48 0.225 0.297375071883 gnomAD-4.0.0 2.05303E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7993E-06 1.15969E-05 0
R/S 31917 Fn3-121 9 rs762845985 0.5633 0.124 1.0 N 0.775 0.314 0.256793551483 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
R/S 31917 Fn3-121 9 rs762845985 0.5633 0.124 1.0 N 0.775 0.314 0.256793551483 gnomAD-4.0.0 4.81141E-06 None None None None N None 0 0 None 0 0 None 0 0 6.3288E-06 0 0
K/N 32113 Fn3-122 9 rs1224317674 0.2541 0.054 None N 0.187 0.122 0.139678290688 gnomAD-2.1.1 4.2E-06 None None None None N None 0 0 None 0 5.66E-05 None 0 None 0 0 0
K/N 32113 Fn3-122 9 rs1224317674 0.2541 0.054 None N 0.187 0.122 0.139678290688 gnomAD-4.0.0 1.62871E-06 None None None None N None 0 0 None 0 2.78614E-05 None 0 0 0 0 0
K/T 32113 Fn3-122 9 rs1377494437 0.0888 -0.208 None N 0.286 0.098 0.112648838833 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 0 9.19118E-04
K/T 32113 Fn3-122 9 rs1377494437 0.0888 -0.208 None N 0.286 0.098 0.112648838833 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 3.16456E-03 0 0 0
K/T 32113 Fn3-122 9 rs1377494437 0.0888 -0.208 None N 0.286 0.098 0.112648838833 gnomAD-4.0.0 6.57125E-06 None None None None N None 0 0 None 0 0 None 0 3.16456E-03 0 0 0
K/T 32408 Fn3-124 10 rs1251245923 0.1121 -0.315 0.211 N 0.319 0.117 0.130388298395 gnomAD-2.1.1 3.18E-05 None None None None N None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
K/T 32408 Fn3-124 10 rs1251245923 0.1121 -0.315 0.211 N 0.319 0.117 0.130388298395 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/T 32408 Fn3-124 10 rs1251245923 0.1121 -0.315 0.211 N 0.319 0.117 0.130388298395 gnomAD-4.0.0 6.5722E-06 None None None None N None 2.41313E-05 0 None 0 0 None 0 0 0 0 0
Q/R 32507 Fn3-125 9 rs368610609 0.1084 0.271 0.642 N 0.335 0.16 None gnomAD-2.1.1 4.08E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.02E-06 0
Q/R 32507 Fn3-125 9 rs368610609 0.1084 0.271 0.642 N 0.335 0.16 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 4.41E-05 0 0
R/K 32608 Fn3-126 9 rs757187219 0.1281 -0.641 0.998 N 0.504 0.321 0.268211541103 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 6.55E-05 None 0 0 0
R/K 32608 Fn3-126 9 rs757187219 0.1281 -0.641 0.998 N 0.504 0.321 0.268211541103 gnomAD-4.0.0 1.3691E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.32029E-05 0
R/T 32608 Fn3-126 9 rs757187219 0.3586 None 0.994 N 0.673 0.357 None gnomAD-4.0.0 6.8455E-07 None None None None N None 0 0 None 0 0 None 1.87371E-05 0 0 0 0
E/D 32905 Fn3-128 10 rs768468641 0.3201 -0.164 0.999 N 0.523 0.136 0.401185642668 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
E/D 32905 Fn3-128 10 rs768468641 0.3201 -0.164 0.999 N 0.523 0.136 0.401185642668 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.41E-05 0 0 0 0
E/D 32905 Fn3-128 10 rs768468641 0.3201 -0.164 0.999 N 0.523 0.136 0.401185642668 gnomAD-4.0.0 6.84273E-07 None None None None N None 0 0 None 0 2.51953E-05 None 0 0 0 0 0
E/G 32905 Fn3-128 10 None 0.6925 None 1.0 N 0.713 0.342 0.451599300725 gnomAD-4.0.0 1.59159E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85922E-06 0 0
E/K 32905 Fn3-128 10 None 0.5139 0.546 0.999 N 0.649 0.327 0.332386209738 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.66E-05 0
E/K 32905 Fn3-128 10 None 0.5139 0.546 0.999 N 0.649 0.327 0.332386209738 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 7.35E-05 0 0
E/K 32905 Fn3-128 10 None 0.5139 0.546 0.999 N 0.649 0.327 0.332386209738 gnomAD-4.0.0 1.42541E-05 None None None None N None 0 0 None 0 0 None 0 0 1.86493E-05 0 1.60138E-05
E/Q 32905 Fn3-128 10 rs763344306 0.3524 0.126 1.0 N 0.685 0.244 0.340992353424 gnomAD-2.1.1 1.43E-05 None None None None N None 4.13E-05 0 None 0 0 None 0 None 0 1.56E-05 1.4041E-04
E/Q 32905 Fn3-128 10 rs763344306 0.3524 0.126 1.0 N 0.685 0.244 0.340992353424 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
E/Q 32905 Fn3-128 10 rs763344306 0.3524 0.126 1.0 N 0.685 0.244 0.340992353424 gnomAD-4.0.0 2.47897E-06 None None None None N None 2.66951E-05 0 None 0 0 None 0 0 8.47693E-07 0 1.60138E-05
E/K 33006 Fn3-129 9 rs201931674 0.2303 0.264 0.978 N 0.503 0.344 0.269111216191 gnomAD-2.1.1 1.22E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.69E-05 0
E/K 33006 Fn3-129 9 rs201931674 0.2303 0.264 0.978 N 0.503 0.344 0.269111216191 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 33006 Fn3-129 9 rs201931674 0.2303 0.264 0.978 N 0.503 0.344 0.269111216191 gnomAD-4.0.0 1.11785E-05 None None None None N None 0 0 None 0 0 None 1.56627E-05 0 1.44343E-05 0 0
V/A 33299 Fn3-130 10 rs794729554 0.2199 -1.205 0.998 N 0.615 0.38 0.619797697146 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
V/A 33299 Fn3-130 10 rs794729554 0.2199 -1.205 0.998 N 0.615 0.38 0.619797697146 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 33299 Fn3-130 10 rs794729554 0.2199 -1.205 0.998 N 0.615 0.38 0.619797697146 gnomAD-4.0.0 3.86181E-06 None None None None N None 0 0 None 0 0 None 0 0 7.22958E-06 0 0
V/M 33299 Fn3-130 10 None 0.1564 None 0.999 N 0.804 0.383 0.555673547925 gnomAD-4.0.0 1.6051E-06 None None None None N None 5.6993E-05 0 None 0 0 None 0 0 0 0 0
T/I 33400 Fn3-131 9 rs1034663911 0.0953 None 0.001 N 0.225 0.099 0.231231049324 gnomAD-4.0.0 7.37633E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.78936E-05
T/S 33400 Fn3-131 9 rs1034663911 0.1098 -0.67 0.005 N 0.153 0.089 0.107399877778 gnomAD-2.1.1 5.91E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.18E-05 0
T/S 33400 Fn3-131 9 rs1034663911 0.1098 -0.67 0.005 N 0.153 0.089 0.107399877778 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/S 33400 Fn3-131 9 rs1034663911 0.1098 -0.67 0.005 N 0.153 0.089 0.107399877778 gnomAD-4.0.0 1.32635E-06 None None None None I None 0 0 None 0 0 None 0 0 1.76494E-06 0 0
K/T 33697 Fn3-132 9 rs1691033741 0.1124 None 0.78 N 0.585 0.179 0.280181792013 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.