Structural position:

  • Domain Type: Fn3
  • Aligned Position: 113
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
R/G 15737 Fn3-1 81 rs376440087 0.7407 None 1.0 N 0.567 0.314 None gnomAD-4.0.0 1.59313E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8622E-06 0 0
R/G 15838 Fn3-2 81 None 0.24 None 0.653 N 0.394 0.163 0.378498632473 gnomAD-4.0.0 6.84684E-07 None None None None I None 2.99509E-05 0 None 0 0 None 0 0 0 0 0
R/L 15838 Fn3-2 81 rs199640194 0.2276 None 0.124 N 0.357 0.234 0.457106177737 gnomAD-4.0.0 1.3694E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79995E-06 0 0
R/Q 15838 Fn3-2 81 rs199640194 0.1068 0.025 0.054 N 0.127 0.082 None gnomAD-2.1.1 2.79342E-04 None None None None I None 1.6559E-04 1.13392E-04 None 0 5.17E-05 None 1.30762E-04 None 1.19952E-04 4.78694E-04 1.40766E-04
R/Q 15838 Fn3-2 81 rs199640194 0.1068 0.025 0.054 N 0.127 0.082 None gnomAD-3.1.2 2.50109E-04 None None None None I None 2.65636E-04 0 0 0 0 None 0 0 3.68091E-04 4.14422E-04 0
R/Q 15838 Fn3-2 81 rs199640194 0.1068 0.025 0.054 N 0.127 0.082 None gnomAD-4.0.0 4.66379E-04 None None None None I None 2.00545E-04 1.33578E-04 None 0 0 None 2.18729E-04 1.64745E-04 5.78426E-04 1.64766E-04 2.72576E-04
K/E 15939 Fn3-3 81 rs1408557748 0.1255 0.354 None N 0.124 0.128 0.156986980423 gnomAD-2.1.1 4.49E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.02E-05 0
K/I 15939 Fn3-3 81 rs760239452 0.1976 None 0.055 N 0.557 0.133 0.362160248664 gnomAD-4.0.0 1.38222E-06 None None None None I None 0 0 None 0 0 None 0 0 1.81126E-06 0 0
K/N 16134 Fn3-4 80 rs772886163 0.6693 0.411 0.999 D 0.625 0.298 0.128392430309 gnomAD-2.1.1 4.03E-06 None None None None I None 6.48E-05 0 None 0 0 None 0 None 0 0 0
K/N 16134 Fn3-4 80 rs772886163 0.6693 0.411 0.999 D 0.625 0.298 0.128392430309 gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
K/N 16134 Fn3-4 80 rs772886163 0.6693 0.411 0.999 D 0.625 0.298 0.128392430309 gnomAD-4.0.0 1.31614E-05 None None None None I None 4.82649E-05 0 None 0 0 None 0 0 0 0 0
K/R 16134 Fn3-4 80 rs1197839427 0.1063 0.223 0.64 N 0.318 0.162 0.18995819373 gnomAD-2.1.1 4.03E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/R 16134 Fn3-4 80 rs1197839427 0.1063 0.223 0.64 N 0.318 0.162 0.18995819373 gnomAD-4.0.0 1.59398E-06 None None None None I None 0 2.28791E-05 None 0 0 None 0 0 0 0 0
R/K 16234 Fn3-5 80 None 0.1135 None 0.122 N 0.262 0.11 0.261217442401 gnomAD-4.0.0 6.96339E-07 None None None None I None 0 0 None 0 0 None 0 0 9.10845E-07 0 0
M/I 16430 Fn3-6 80 None 0.3422 None 0.969 N 0.35 0.27 0.633181949713 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
M/L 16430 Fn3-6 80 None 0.1405 None 0.48 N 0.289 0.208 0.444706120422 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
M/T 16430 Fn3-6 80 rs973490041 0.1848 0.631 0.912 N 0.443 0.245 0.666668332583 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
M/T 16430 Fn3-6 80 rs973490041 0.1848 0.631 0.912 N 0.443 0.245 0.666668332583 gnomAD-4.0.0 4.06086E-06 None None None None I None 0 0 None 0 0 None 0 0 4.82029E-06 0 0
K/E 16630 Fn3-8 80 rs374031591 0.2268 0.228 0.92 N 0.305 0.151 None gnomAD-2.1.1 4.04E-06 None None None None I None 6.48E-05 0 None 0 0 None 0 None 0 0 0
K/E 16630 Fn3-8 80 rs374031591 0.2268 0.228 0.92 N 0.305 0.151 None gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
A/T 16730 Fn3-9 80 None 0.251 None 0.993 N 0.633 0.198 0.335414705075 gnomAD-4.0.0 3.42348E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49938E-06 0 0
A/V 16730 Fn3-9 80 rs763483590 0.3778 -0.03 0.955 N 0.417 0.213 0.483301346737 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 5.65E-05 None 0 None 0 0 0
A/V 16730 Fn3-9 80 rs763483590 0.3778 -0.03 0.955 N 0.417 0.213 0.483301346737 gnomAD-4.0.0 1.59398E-06 None None None None I None 0 0 None 0 2.79111E-05 None 0 0 0 0 0
A/T 16933 Fn3-11 82 rs794729452 0.0964 -0.402 0.925 N 0.377 0.19 None gnomAD-2.1.1 3.19E-05 None None None None I None 1.14732E-04 0 None 0 0 None 0 None 0 0 0
A/T 16933 Fn3-11 82 rs794729452 0.0964 -0.402 0.925 N 0.377 0.19 None gnomAD-3.1.2 2.63E-05 None None None None I None 9.65E-05 0 0 0 0 None 0 0 0 0 0
A/T 16933 Fn3-11 82 rs794729452 0.0964 -0.402 0.925 N 0.377 0.19 None gnomAD-4.0.0 9.92066E-06 None None None None I None 6.67878E-05 0 None 0 0 None 0 0 9.32754E-06 0 0
K/E 17126 Fn3-12 80 None 0.3602 None 0.999 N 0.56 0.401 0.3085936734 gnomAD-4.0.0 3.18577E-06 None None None None I None 5.67151E-05 0 None 0 0 None 0 0 0 1.43303E-05 0
K/M 17126 Fn3-12 80 None 0.5314 None 1.0 N 0.571 0.548 0.43046518545 gnomAD-4.0.0 6.84513E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99784E-07 0 0
K/R 17126 Fn3-12 80 rs757728544 0.1048 0.007 0.999 N 0.478 0.275 0.264081493735 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 0 None 0 3.57E-05 0
K/R 17126 Fn3-12 80 rs757728544 0.1048 0.007 0.999 N 0.478 0.275 0.264081493735 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/R 17126 Fn3-12 80 rs757728544 0.1048 0.007 0.999 N 0.478 0.275 0.264081493735 gnomAD-4.0.0 8.68015E-06 None None None None I None 0 0 None 0 0 None 0 0 1.01753E-05 1.0981E-05 1.60241E-05
A/T 17227 Fn3-13 81 rs904223315 0.1454 -0.116 1.0 N 0.691 0.289 0.455265801863 gnomAD-2.1.1 1.61E-05 None None None None I None 0 8.71E-05 None 0 0 None 3.27E-05 None 0 0 0
A/T 17227 Fn3-13 81 rs904223315 0.1454 -0.116 1.0 N 0.691 0.289 0.455265801863 gnomAD-4.0.0 1.09575E-05 None None None None I None 2.99455E-05 8.94775E-05 None 0 0 None 0 0 7.20154E-06 1.16122E-05 3.31664E-05
R/K 17450 Fn3-14 82 rs778572247 0.1754 0.026 0.001 N 0.195 0.099 0.200317383148 gnomAD-2.1.1 1.22E-05 None None None None I None 0 0 None 0 1.7094E-04 None 0 None 0 0 0
R/K 17450 Fn3-14 82 rs778572247 0.1754 0.026 0.001 N 0.195 0.099 0.200317383148 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.95008E-04 None 0 0 0 0 0
R/K 17450 Fn3-14 82 rs778572247 0.1754 0.026 0.001 N 0.195 0.099 0.200317383148 gnomAD-4.0.0 9.92525E-06 None None None None I None 0 0 None 0 3.37109E-04 None 0 0 0 0 1.60282E-05
R/T 17450 Fn3-14 82 None 0.6301 None 0.549 N 0.484 0.093 0.276482976112 gnomAD-4.0.0 6.84963E-07 None None None None I None 0 0 None 0 0 None 0 0 9.0005E-07 0 0
A/E 17549 Fn3-15 80 None 0.2503 None 0.852 N 0.35 0.257 0.387529464389 gnomAD-4.0.0 6.87402E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.66561E-05
A/P 17649 Fn3-16 81 rs2055287229 0.2292 None 0.741 N 0.368 0.161 0.225902525712 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/N 17842 Fn3-17 79 None 0.7989 None 1.0 N 0.675 0.377 0.276482976112 gnomAD-4.0.0 6.84901E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00003E-07 0 0
E/K 17942 Fn3-18 81 rs2054564830 0.1213 None 0.055 N 0.317 0.138 0.232513804876 gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
E/K 17942 Fn3-18 81 rs2054564830 0.1213 None 0.055 N 0.317 0.138 0.232513804876 gnomAD-4.0.0 2.48192E-06 None None None None I None 5.34945E-05 0 None 0 0 None 0 0 0 0 0
A/T 18251 Fn3-20 86 None 0.1021 None 0.669 N 0.249 0.183 0.250579442822 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/G 18354 Fn3-21 83 None 0.1324 None 0.09 N 0.471 0.104 0.247872288689 gnomAD-4.0.0 1.59318E-06 None None None None N None 5.67279E-05 0 None 0 0 None 0 0 0 0 0
E/Q 18354 Fn3-21 83 rs1559697777 0.1302 None 0.324 N 0.339 0.096 0.234412748748 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/Q 18354 Fn3-21 83 rs1559697777 0.1302 None 0.324 N 0.339 0.096 0.234412748748 gnomAD-4.0.0 3.84745E-06 None None None None N None 1.69285E-05 0 None 0 0 None 0 0 4.7912E-06 0 0
R/C 18558 Fn3-22 80 rs774262905 0.2758 -0.053 1.0 N 0.715 0.42 0.69737875697 gnomAD-2.1.1 1.22E-05 None None None None I None 0 0 None 0 5.64E-05 None 3.31E-05 None 0 8.99E-06 0
R/C 18558 Fn3-22 80 rs774262905 0.2758 -0.053 1.0 N 0.715 0.42 0.69737875697 gnomAD-4.0.0 1.37327E-05 None None None None I None 0 0 None 0 0 None 0 0 1.62387E-05 2.33721E-05 0
R/H 18558 Fn3-22 80 rs115867512 0.1657 -0.789 1.0 N 0.697 0.328 None gnomAD-2.1.1 7.95E-05 None None None None I None 2.48468E-04 5.71E-05 None 0 5.2E-05 None 3.33E-05 None 0 7.91E-05 2.84252E-04
R/H 18558 Fn3-22 80 rs115867512 0.1657 -0.789 1.0 N 0.697 0.328 None gnomAD-3.1.2 1.51314E-04 None None None None I None 2.65495E-04 1.31268E-04 0 0 0 None 0 0 1.32392E-04 0 4.78011E-04
R/H 18558 Fn3-22 80 rs115867512 0.1657 -0.789 1.0 N 0.697 0.328 None 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
R/H 18558 Fn3-22 80 rs115867512 0.1657 -0.789 1.0 N 0.697 0.328 None gnomAD-4.0.0 1.1009E-04 None None None None I None 2.13709E-04 6.70084E-05 None 0 8.97545E-05 None 1.56622E-05 0 1.08843E-04 3.32285E-05 3.3761E-04
I/M 19068 Fn3-26 81 None 0.0728 None 0.001 N 0.209 0.06 0.266843984389 gnomAD-4.0.0 1.59212E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85959E-06 0 0
S/I 19263 Fn3-27 81 None 0.101 None 0.001 N 0.157 0.162 0.362758974969 gnomAD-4.0.0 6.323E-06 None None None None I None 0 0 None 0 0 None 0 0 8.25034E-06 0 0
S/N 19263 Fn3-27 81 rs772342556 0.128 0.054 0.883 N 0.262 0.106 0.185906805712 gnomAD-2.1.1 3.1E-05 None None None None I None 0 0 None 0 0 None 2.40096E-04 None 0 0 0
S/N 19263 Fn3-27 81 rs772342556 0.128 0.054 0.883 N 0.262 0.106 0.185906805712 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 0 4.14594E-04 0
S/N 19263 Fn3-27 81 rs772342556 0.128 0.054 0.883 N 0.262 0.106 0.185906805712 gnomAD-4.0.0 8.88764E-06 None None None None I None 0 0 None 0 0 None 0 1.65782E-04 0 1.27871E-04 3.27354E-05
I/M 19364 Fn3-28 81 rs182489815 0.0912 -0.303 0.988 N 0.307 0.151 None gnomAD-2.1.1 4.09E-06 None None None None I None 6.49E-05 0 None 0 0 None 0 None 0 0 0
I/M 19364 Fn3-28 81 rs182489815 0.0912 -0.303 0.988 N 0.307 0.151 None gnomAD-3.1.2 1.31E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
I/M 19364 Fn3-28 81 rs182489815 0.0912 -0.303 0.988 N 0.307 0.151 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
I/M 19364 Fn3-28 81 rs182489815 0.0912 -0.303 0.988 N 0.307 0.151 None gnomAD-4.0.0 1.31392E-05 None None None None I None 4.81255E-05 0 None 0 0 None 0 0 0 0 0
I/N 19364 Fn3-28 81 rs1239668517 0.2549 0.074 0.988 N 0.491 0.356 0.757756501284 gnomAD-2.1.1 4.09E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.99E-06 0
I/N 19364 Fn3-28 81 rs1239668517 0.2549 0.074 0.988 N 0.491 0.356 0.757756501284 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/N 19364 Fn3-28 81 rs1239668517 0.2549 0.074 0.988 N 0.491 0.356 0.757756501284 gnomAD-4.0.0 4.35677E-06 None None None None I None 0 0 None 0 0 None 0 0 5.9529E-06 0 0
I/V 19364 Fn3-28 81 rs1472130936 0.0686 -0.084 0.061 N 0.12 0.079 0.400613892164 gnomAD-2.1.1 4.09E-06 None None None None I None 0 0 None 0 0 None 3.43E-05 None 0 0 0
I/V 19364 Fn3-28 81 rs1472130936 0.0686 -0.084 0.061 N 0.12 0.079 0.400613892164 gnomAD-4.0.0 3.21792E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.91724E-05 0
L/M 19559 Fn3-29 81 None 0.1145 None 0.136 N 0.253 0.035 0.413761986042 gnomAD-4.0.0 6.84595E-07 None None None None I None 2.98954E-05 0 None 0 0 None 0 0 0 0 0
L/Q 19559 Fn3-29 81 rs76604657 0.1522 -0.209 0.966 N 0.49 0.382 None gnomAD-2.1.1 1.43533E-04 None None None None I None 0 0 None 0 2.07987E-03 None 0 None 0 0 0
L/Q 19559 Fn3-29 81 rs76604657 0.1522 -0.209 0.966 N 0.49 0.382 None gnomAD-3.1.2 1.18315E-04 None None None None I None 0 0 0 0 3.48567E-03 None 0 0 0 0 0
L/Q 19559 Fn3-29 81 rs76604657 0.1522 -0.209 0.966 N 0.49 0.382 None 1000 genomes 5.99042E-04 None None None None I None 0 0 None None 3E-03 0 None None None 0 None
L/Q 19559 Fn3-29 81 rs76604657 0.1522 -0.209 0.966 N 0.49 0.382 None gnomAD-4.0.0 1.76068E-04 None None None None I None 0 0 None 0 6.34358E-03 None 0 0 0 0 1.60169E-05
L/V 19559 Fn3-29 81 None 0.087 None 0.454 N 0.359 0.087 0.459463830659 gnomAD-4.0.0 6.84595E-07 None None None None I None 0 0 None 3.82848E-05 0 None 0 0 0 0 0
E/D 19659 Fn3-30 81 None 0.1771 None 0.722 N 0.417 0.099 0.368554958709 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 19659 Fn3-30 81 rs2050629562 0.2664 None 0.565 N 0.443 0.257 0.260249123532 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 19659 Fn3-30 81 rs2050629562 0.2664 None 0.565 N 0.443 0.257 0.260249123532 gnomAD-4.0.0 7.10514E-06 None None None None I None 0 0 None 0 0 None 0 0 8.43487E-06 0 0
E/Q 19659 Fn3-30 81 None 0.2164 None 0.075 N 0.235 0.111 0.301789629655 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/E 19762 Fn3-31 83 rs1311886410 0.0888 -0.102 0.001 N 0.291 0.069 0.213573922156 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
A/E 19762 Fn3-31 83 rs1311886410 0.0888 -0.102 0.001 N 0.291 0.069 0.213573922156 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/E 19762 Fn3-31 83 rs1311886410 0.0888 -0.102 0.001 N 0.291 0.069 0.213573922156 gnomAD-4.0.0 1.79746E-05 None None None None I None 0 0 None 0 0 None 0 0 2.4584E-05 0 0
I/T 20055 Fn3-33 79 rs755318489 0.1221 -0.232 0.92 N 0.437 0.198 None gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.58E-05 None 0 None 0 0 0
I/T 20055 Fn3-33 79 rs755318489 0.1221 -0.232 0.92 N 0.437 0.198 None gnomAD-4.0.0 4.10596E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49806E-06 0 1.65678E-05
I/V 20055 Fn3-33 79 rs1445750788 0.0736 -0.109 0.675 N 0.336 0.149 0.455081427078 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
I/V 20055 Fn3-33 79 rs1445750788 0.0736 -0.109 0.675 N 0.336 0.149 0.455081427078 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 20055 Fn3-33 79 rs1445750788 0.0736 -0.109 0.675 N 0.336 0.149 0.455081427078 gnomAD-4.0.0 2.47928E-05 None None None None I None 0 0 None 0 0 None 0 0 3.39106E-05 0 0
K/E 20251 Fn3-34 81 None 0.6582 None 0.999 N 0.601 0.365 0.314716216878 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
K/M 20251 Fn3-34 81 rs1314635889 0.644 None 1.0 N 0.583 0.413 0.407357902709 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/M 20251 Fn3-34 81 rs1314635889 0.644 None 1.0 N 0.583 0.413 0.407357902709 gnomAD-4.0.0 6.57575E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47093E-05 0 0
K/N 20251 Fn3-34 81 rs756340284 0.8412 0.243 1.0 N 0.684 0.382 0.1749357433 gnomAD-2.1.1 8.07E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.79E-05 0
K/N 20251 Fn3-34 81 rs756340284 0.8412 0.243 1.0 N 0.684 0.382 0.1749357433 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 1.9425E-04 None 0 0 0 0 0
K/N 20251 Fn3-34 81 rs756340284 0.8412 0.243 1.0 N 0.684 0.382 0.1749357433 gnomAD-4.0.0 2.56335E-06 None None None None I None 0 0 None 0 4.85531E-05 None 0 0 0 0 0
L/F 20350 Fn3-35 80 rs1162158537 0.1569 -0.515 0.934 N 0.321 0.185 0.598957545849 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.6E-05 None 0 None 0 0 0
L/F 20350 Fn3-35 80 rs1162158537 0.1569 -0.515 0.934 N 0.321 0.185 0.598957545849 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 3.8835E-04 None 0 0 0 0 0
L/F 20350 Fn3-35 80 rs1162158537 0.1569 -0.515 0.934 N 0.321 0.185 0.598957545849 gnomAD-4.0.0 8.07759E-05 None None None None I None 0 0 None 0 1.45843E-03 None 0 0 4.79017E-06 0 2.8456E-05
I/N 20452 Fn3-36 82 rs375946418 0.5243 0.012 0.996 N 0.525 0.393 None gnomAD-2.1.1 8.89E-06 None None None None I None 0 0 None 0 0 None 4.23E-05 None 0 9.62E-06 0
I/N 20452 Fn3-36 82 rs375946418 0.5243 0.012 0.996 N 0.525 0.393 None gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/N 20452 Fn3-36 82 rs375946418 0.5243 0.012 0.996 N 0.525 0.393 None gnomAD-4.0.0 1.00986E-05 None None None None I None 0 0 None 0 0 None 0 0 1.1151E-05 1.18265E-05 3.27086E-05
I/T 20452 Fn3-36 82 None 0.2872 None 0.92 N 0.445 0.201 0.645970908164 gnomAD-4.0.0 6.98158E-07 None None None None I None 0 0 None 0 0 None 0 0 9.10891E-07 0 0
I/V 20452 Fn3-36 82 None 0.0941 None 0.061 N 0.103 0.101 0.39709148275 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/Q 20647 Fn3-37 79 rs751883286 0.3736 0.303 1.0 N 0.665 0.399 0.402755899245 gnomAD-2.1.1 8.04E-06 None None None None I None 0 5.8E-05 None 0 0 None 0 None 0 0 0
K/Q 20647 Fn3-37 79 rs751883286 0.3736 0.303 1.0 N 0.665 0.399 0.402755899245 gnomAD-4.0.0 1.59175E-06 None None None None I None 0 2.28697E-05 None 0 0 None 0 0 0 0 0
E/K 20748 Fn3-38 81 rs774998817 0.4556 None 0.978 N 0.537 0.309 0.393775345888 gnomAD-4.0.0 1.5921E-06 None None None None I None 0 2.28843E-05 None 0 0 None 0 0 0 0 0
K/T 20943 Fn3-39 80 None 0.55 None 1.0 N 0.619 0.508 0.39798585902 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
Q/H 21150 Fn3-41 87 None 0.4901 None 0.999 N 0.563 0.285 0.188950314367 gnomAD-4.0.0 6.85493E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00469E-07 0 0
E/K 21345 Fn3-42 80 rs776495338 0.218 0.594 0.438 N 0.205 0.253 0.225215365344 gnomAD-2.1.1 2.01E-05 None None None None I None 6.46E-05 0 None 0 0 None 3.27E-05 None 9.28E-05 0 1.65673E-04
E/K 21345 Fn3-42 80 rs776495338 0.218 0.594 0.438 N 0.205 0.253 0.225215365344 gnomAD-3.1.2 2.63E-05 None None None None I None 9.66E-05 0 0 0 0 None 0 0 0 0 0
E/K 21345 Fn3-42 80 rs776495338 0.218 0.594 0.438 N 0.205 0.253 0.225215365344 gnomAD-4.0.0 1.42579E-05 None None None None I None 9.35354E-05 0 None 0 0 None 3.12383E-05 0 9.32641E-06 3.29417E-05 0
A/V 21446 Fn3-43 81 None 0.1203 None 0.645 N 0.358 0.218 0.455909487837 gnomAD-4.0.0 1.59252E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.4332E-05 0
R/G 21639 Fn3-44 81 rs1432889079 0.9079 None 1.0 N 0.579 0.373 None gnomAD-4.0.0 2.053E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69885E-06 0 0
R/Q 21639 Fn3-44 81 rs373282633 0.4885 0.116 1.0 N 0.681 0.322 None gnomAD-2.1.1 3.22E-05 None None None None I None 4.13E-05 2.83E-05 None 0 5.13E-05 None 0 None 0 4.7E-05 0
R/Q 21639 Fn3-44 81 rs373282633 0.4885 0.116 1.0 N 0.681 0.322 None gnomAD-3.1.2 1.97E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
R/Q 21639 Fn3-44 81 rs373282633 0.4885 0.116 1.0 N 0.681 0.322 None gnomAD-4.0.0 4.40076E-05 None None None None I None 1.3354E-05 1.6675E-05 None 0 2.23055E-04 None 0 0 4.74744E-05 0 4.80492E-05
K/N 21739 Fn3-45 81 rs1457832691 0.6697 0.236 0.324 N 0.34 0.12 0.204665344411 gnomAD-2.1.1 4.06E-06 None None None None I None 0 2.91E-05 None 0 0 None 0 None 0 0 0
K/N 21739 Fn3-45 81 rs1457832691 0.6697 0.236 0.324 N 0.34 0.12 0.204665344411 gnomAD-4.0.0 1.60857E-06 None None None None I None 0 2.29495E-05 None 0 0 None 0 0 0 0 0
A/E 21839 Fn3-46 83 None 0.8284 None 0.976 N 0.549 0.37 0.573444017615 gnomAD-4.0.0 1.36988E-06 None None None None I None 0 0 None 0 0 None 0 0 1.80006E-06 0 0
A/T 21839 Fn3-46 83 rs56378177 0.2615 -0.315 0.929 N 0.505 0.193 None gnomAD-2.1.1 6.82E-05 None None None None I None 1.66099E-04 2.84E-05 None 0 2.6058E-04 None 1.97628E-04 None 0 2.35E-05 0
A/T 21839 Fn3-46 83 rs56378177 0.2615 -0.315 0.929 N 0.505 0.193 None gnomAD-3.1.2 8.55E-05 None None None None I None 2.17192E-04 0 0 0 1.94099E-04 None 0 0 4.41E-05 0 0
A/T 21839 Fn3-46 83 rs56378177 0.2615 -0.315 0.929 N 0.505 0.193 None gnomAD-4.0.0 5.64476E-05 None None None None I None 1.46714E-04 0 None 0 3.81286E-04 None 0 3.32779E-04 3.73182E-05 1.32109E-04 8.01667E-05
A/V 21839 Fn3-46 83 rs55948748 0.3009 -0.036 0.159 N 0.315 0.119 None gnomAD-2.1.1 4.4563E-03 None None None None I None 4.36986E-02 2.84447E-03 None 1.74825E-03 0 None 3.29E-05 None 4.01E-05 4.23842E-04 2.12344E-03
A/V 21839 Fn3-46 83 rs55948748 0.3009 -0.036 0.159 N 0.315 0.119 None gnomAD-3.1.2 1.22502E-02 None None None None I None 4.16848E-02 5.37634E-03 0 1.7301E-03 0 None 0 0 3.97106E-04 0 1.00575E-02
A/V 21839 Fn3-46 83 rs55948748 0.3009 -0.036 0.159 N 0.315 0.119 None 1000 genomes 1.41773E-02 None None None None I None 5.07E-02 4.3E-03 None None 0 1E-03 None None None 0 None
A/V 21839 Fn3-46 83 rs55948748 0.3009 -0.036 0.159 N 0.315 0.119 None gnomAD-4.0.0 2.49612E-03 None None None None I None 4.33646E-02 3.62258E-03 None 1.59096E-03 0 None 0 3.32557E-03 2.46808E-04 4.40315E-05 3.1257E-03
K/N 22035 Fn3-47 80 rs373681189 0.75 0.219 0.998 N 0.495 0.223 0.221019684889 gnomAD-2.1.1 2.52E-05 None None None None I None 8.29E-05 0 None 0 0 None 0 None 0 3.14E-05 1.42328E-04
K/N 22035 Fn3-47 80 rs373681189 0.75 0.219 0.998 N 0.495 0.223 0.221019684889 gnomAD-3.1.2 5.26E-05 None None None None I None 9.65E-05 0 0 0 0 None 0 0 5.88E-05 0 0
K/N 22035 Fn3-47 80 rs373681189 0.75 0.219 0.998 N 0.495 0.223 0.221019684889 gnomAD-4.0.0 4.53513E-05 None None None None I None 5.35217E-05 0 None 0 0 None 0 0 5.26545E-05 0 1.12421E-04
K/R 22035 Fn3-47 80 None 0.1058 None 0.989 N 0.432 0.227 0.335910606209 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/E 22135 Fn3-48 81 None 0.3054 None 0.067 N 0.369 0.167 0.202949470691 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 3.66327E-05
K/N 22237 Fn3-49 82 None 0.4838 None 0.988 N 0.603 0.271 0.201204373187 gnomAD-4.0.0 1.59508E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86546E-06 0 0
E/D 22433 Fn3-50 80 None 0.3701 None 0.704 N 0.298 0.074 0.194818534648 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/G 22433 Fn3-50 80 rs2047336036 0.5205 None 0.826 N 0.423 0.235 0.285316908763 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 22433 Fn3-50 80 rs2047336036 0.5205 None 0.826 N 0.423 0.235 0.285316908763 gnomAD-4.0.0 6.5741E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47076E-05 0 0
E/K 22528 Fn3-51 78 rs1416365418 0.1683 0.77 0.645 N 0.513 0.299 0.264081493735 gnomAD-2.1.1 4.03E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
E/K 22528 Fn3-51 78 rs1416365418 0.1683 0.77 0.645 N 0.513 0.299 0.264081493735 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 22528 Fn3-51 78 rs1416365418 0.1683 0.77 0.645 N 0.513 0.299 0.264081493735 gnomAD-4.0.0 3.84521E-06 None None None None I None 1.69153E-05 0 None 0 0 None 0 0 4.789E-06 0 0
K/R 22723 Fn3-52 81 rs2154175020 0.0862 None 0.032 N 0.371 0.084 0.235038932564 gnomAD-4.0.0 4.77791E-06 None None None None N None 0 0 None 0 8.32963E-05 None 0 0 0 0 0
L/S 22823 Fn3-53 81 rs770040120 0.3038 -0.127 0.669 N 0.573 0.334 0.628610474668 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.92E-06 0
L/S 22823 Fn3-53 81 rs770040120 0.3038 -0.127 0.669 N 0.573 0.334 0.628610474668 gnomAD-4.0.0 1.59253E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86041E-06 0 0
T/I 22921 Fn3-54 81 rs534567766 0.2751 -0.033 0.004 N 0.263 0.253 0.243398259712 gnomAD-2.1.1 1.93436E-04 None None None None I None 0 0 None 0 0 None 1.56996E-03 None 0 7.85E-06 7.05617E-04
T/I 22921 Fn3-54 81 rs534567766 0.2751 -0.033 0.004 N 0.263 0.253 0.243398259712 gnomAD-3.1.2 6.57E-05 None None None None I None 0 0 0 0 0 None 0 0 0 2.06954E-03 0
T/I 22921 Fn3-54 81 rs534567766 0.2751 -0.033 0.004 N 0.263 0.253 0.243398259712 1000 genomes 3.99361E-04 None None None None I None 0 0 None None 0 0 None None None 2E-03 None
T/I 22921 Fn3-54 81 rs534567766 0.2751 -0.033 0.004 N 0.263 0.253 0.243398259712 gnomAD-4.0.0 9.73206E-05 None None None None I None 0 0 None 0 0 None 0 4.95868E-04 1.69559E-06 1.59274E-03 1.12072E-04
H/R 23119 Fn3-55 80 None 0.0764 None 0.012 N 0.244 0.251 0.171388866994 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/H 23321 Fn3-57 82 None 0.1345 None 0.946 N 0.424 0.327 0.312001716656 gnomAD-4.0.0 3.42293E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49894E-06 0 0
D/N 23321 Fn3-57 82 rs571879486 0.0794 0.24 0.844 N 0.322 0.199 0.239901079897 gnomAD-2.1.1 4.04E-06 None None None None I None 0 2.91E-05 None 0 0 None 0 None 0 0 0
D/N 23321 Fn3-57 82 rs571879486 0.0794 0.24 0.844 N 0.322 0.199 0.239901079897 gnomAD-3.1.2 1.32E-05 None None None None I None 0 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
D/N 23321 Fn3-57 82 rs571879486 0.0794 0.24 0.844 N 0.322 0.199 0.239901079897 1000 genomes 1.99681E-04 None None None None I None 0 1.4E-03 None None 0 0 None None None 0 None
D/N 23321 Fn3-57 82 rs571879486 0.0794 0.24 0.844 N 0.322 0.199 0.239901079897 gnomAD-4.0.0 3.71995E-06 None None None None I None 0 1.66856E-05 None 0 0 None 0 0 2.54375E-06 2.19916E-05 0
E/K 23514 Fn3-58 80 None 0.4494 None 0.538 N 0.431 0.235 0.218845423259 gnomAD-4.0.0 6.84261E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99549E-07 0 0
S/R 23610 Fn3-59 79 rs12464787 0.5221 0.156 0.988 N 0.423 0.266 0.221734844693 gnomAD-2.1.1 8.06E-06 None None None None I None 0 0 None 0 1.12549E-04 None 0 None 0 0 0
S/R 23610 Fn3-59 79 rs12464787 0.5221 0.156 0.988 N 0.423 0.266 0.221734844693 gnomAD-4.0.0 2.05324E-06 None None None None I None 0 0 None 0 2.5296E-05 None 0 0 8.99635E-07 0 1.65717E-05
R/I 23806 Fn3-60 81 None 0.9106 None 0.991 N 0.596 0.41 0.675195094354 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/T 23806 Fn3-60 81 None 0.9674 None 0.969 N 0.521 0.406 0.60163206408 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
M/I 23906 Fn3-61 81 None 0.1697 None None N 0.052 0.15 0.332902724076 gnomAD-4.0.0 6.84324E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99573E-07 0 0
M/T 23906 Fn3-61 81 None 0.1921 None 0.024 N 0.386 0.264 0.507449927524 gnomAD-4.0.0 5.47444E-06 None None None None I None 0 0 None 0 0 None 0 0 7.19642E-06 0 0
K/T 24202 Fn3-63 81 None 0.2901 None 1.0 N 0.629 0.517 0.355034743287 gnomAD-4.0.0 2.22943E-06 None None None None N None 0 0 None 0 0 None 0 0 9.44928E-07 3.12588E-05 0
S/Y 24404 Fn3-65 82 None 0.18 None 0.873 N 0.527 0.372 0.603539076606 gnomAD-4.0.0 1.36879E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99593E-07 1.15939E-05 0
R/S 24888 Fn3-68 81 rs1286127438 0.9815 None 0.892 N 0.521 0.265 0.247872288689 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/S 24888 Fn3-68 81 rs1286127438 0.9815 None 0.892 N 0.521 0.265 0.247872288689 gnomAD-4.0.0 6.57661E-06 None None None None I None 2.41348E-05 0 None 0 0 None 0 0 0 0 0
R/T 24888 Fn3-68 81 rs1708151139 0.9608 None 0.967 N 0.477 0.403 0.376216005999 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/T 24888 Fn3-68 81 rs1708151139 0.9608 None 0.967 N 0.477 0.403 0.376216005999 gnomAD-4.0.0 5.57881E-06 None None None None I None 9.34879E-05 0 None 0 0 None 0 0 0 0 3.20359E-05
I/M 24988 Fn3-69 81 rs777883873 0.1138 None 0.987 N 0.475 0.21 0.270889551736 gnomAD-4.0.0 2.73742E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59831E-06 0 0
I/T 24988 Fn3-69 81 None 0.2981 None 0.967 N 0.515 0.323 0.652561814978 gnomAD-4.0.0 1.59189E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85928E-06 0 0
A/V 25086 Fn3-70 81 rs1707949011 0.3253 None 0.014 N 0.304 0.312 0.284150004643 gnomAD-4.0.0 4.80129E-06 None None None None I None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
A/T 25384 Fn3-72 81 None 0.1023 None 1.0 N 0.699 0.308 0.473538153929 gnomAD-4.0.0 2.73967E-06 None None None None I None 0 0 None 0 0 None 0 0 3.60086E-06 0 0
K/N 25486 Fn3-73 82 None 0.35 None 0.967 N 0.477 0.241 0.238705975628 gnomAD-4.0.0 1.5937E-06 None None None None I None 0 0 None 0 2.78893E-05 None 0 0 0 0 0
E/D 25680 Fn3-74 80 None 0.2126 None 0.941 N 0.375 0.22 0.336400405673 gnomAD-4.0.0 6.84361E-07 None None None None I None 2.99007E-05 0 None 0 0 None 0 0 0 0 0
E/K 25680 Fn3-74 80 rs1385780245 0.4369 0.548 0.996 N 0.572 0.415 0.307966526162 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
E/K 25680 Fn3-74 80 rs1385780245 0.4369 0.548 0.996 N 0.572 0.415 0.307966526162 gnomAD-4.0.0 3.1841E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71961E-06 0 0
R/K 25970 Fn3-76 81 rs1356017017 0.5501 0.281 0.873 N 0.436 0.201 0.342865806769 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
R/K 25970 Fn3-76 81 rs1356017017 0.5501 0.281 0.873 N 0.436 0.201 0.342865806769 gnomAD-4.0.0 1.5917E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85945E-06 0 0
I/T 26070 Fn3-77 81 None 0.3374 None 1.0 N 0.539 0.439 0.740325958804 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
I/V 26070 Fn3-77 81 rs765860384 0.0938 -0.108 0.993 N 0.342 0.165 0.512079609283 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
I/V 26070 Fn3-77 81 rs765860384 0.0938 -0.108 0.993 N 0.342 0.165 0.512079609283 gnomAD-4.0.0 1.59172E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85948E-06 0 0
A/P 26168 Fn3-78 81 None 0.9799 None 0.983 N 0.588 0.389 0.491996647052 gnomAD-4.0.0 6.84955E-07 None None None None I None 0 2.24095E-05 None 0 0 None 0 0 0 0 0
A/V 26168 Fn3-78 81 rs755972936 0.5943 -0.04 0.944 N 0.503 0.309 0.431490205687 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 0 0
A/V 26168 Fn3-78 81 rs755972936 0.5943 -0.04 0.944 N 0.503 0.309 0.431490205687 gnomAD-4.0.0 1.59538E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43559E-05 0
A/G 26466 Fn3-80 81 rs762829887 0.2615 -0.197 0.014 N 0.302 0.129 0.274366138417 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
A/G 26466 Fn3-80 81 rs762829887 0.2615 -0.197 0.014 N 0.302 0.129 0.274366138417 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/G 26466 Fn3-80 81 rs762829887 0.2615 -0.197 0.014 N 0.302 0.129 0.274366138417 gnomAD-4.0.0 8.67826E-06 None None None None I None 0 0 None 0 0 None 0 0 1.10199E-05 0 1.60154E-05
K/E 26568 Fn3-81 82 rs753685639 0.2069 0.351 0.067 N 0.359 0.218 0.206339911435 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
K/E 26568 Fn3-81 82 rs753685639 0.2069 0.351 0.067 N 0.359 0.218 0.206339911435 gnomAD-4.0.0 1.59195E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85887E-06 0 0
E/K 26762 Fn3-82 80 None 0.5419 None 0.763 N 0.507 0.32 0.247872288689 gnomAD-4.0.0 1.59164E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85922E-06 0 0
E/K 26858 Fn3-83 79 None 0.4024 None 0.888 N 0.48 0.274 0.281780670237 gnomAD-4.0.0 4.79003E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29699E-06 0 0
R/S 27052 Fn3-84 81 None 0.9907 None 0.892 N 0.578 0.209 0.141422826196 gnomAD-4.0.0 6.85158E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00132E-07 0 0
R/T 27052 Fn3-84 81 rs762209719 0.9825 0.202 0.967 N 0.525 0.437 0.368554958709 gnomAD-2.1.1 1.22E-05 None None None None I None 0 0 None 0 0 None 0 None 9.35E-05 8.94E-06 0
R/T 27052 Fn3-84 81 rs762209719 0.9825 0.202 0.967 N 0.525 0.437 0.368554958709 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 2.82592E-04 0 0 0 0
R/T 27052 Fn3-84 81 rs762209719 0.9825 0.202 0.967 N 0.525 0.437 0.368554958709 gnomAD-4.0.0 1.67018E-05 None None None None I None 0 0 None 0 0 None 1.88495E-04 0 2.39835E-06 0 0
I/T 27152 Fn3-85 81 rs756551242 0.2087 -0.176 0.822 N 0.509 0.19 None gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
I/T 27152 Fn3-85 81 rs756551242 0.2087 -0.176 0.822 N 0.509 0.19 None gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/T 27152 Fn3-85 81 rs756551242 0.2087 -0.176 0.822 N 0.509 0.19 None gnomAD-4.0.0 4.33879E-06 None None None None I None 0 0 None 0 0 None 0 0 5.93369E-06 0 0
A/T 27250 Fn3-86 81 None 0.3692 None 1.0 N 0.707 0.313 0.382592752248 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.21507E-04 0
A/V 27250 Fn3-86 81 None 0.461 None 1.0 N 0.643 0.435 0.467923293426 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/I 27449 Fn3-87 81 rs750788494 0.5055 0.44 0.983 N 0.647 0.423 0.466740653422 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/Q 27449 Fn3-87 81 rs925851202 0.2062 None 0.935 N 0.471 0.299 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 0 4.77555E-04
K/Q 27449 Fn3-87 81 rs925851202 0.2062 None 0.935 N 0.471 0.299 None gnomAD-4.0.0 6.57488E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 4.77555E-04
A/E 27549 Fn3-88 81 rs749950083 0.2387 -0.395 0.994 N 0.662 0.275 0.512883945787 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
A/V 27549 Fn3-88 81 rs749950083 0.0946 0.072 0.919 N 0.467 0.238 0.454238212503 gnomAD-2.1.1 3.19E-05 None None None None I None 0 1.17924E-03 None 0 0 None 0 None 0 0 0
A/V 27549 Fn3-88 81 rs749950083 0.0946 0.072 0.919 N 0.467 0.238 0.454238212503 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
A/V 27549 Fn3-88 81 rs749950083 0.0946 0.072 0.919 N 0.467 0.238 0.454238212503 gnomAD-4.0.0 3.84376E-06 None None None None I None 0 5.08561E-05 None 0 0 None 0 0 0 0 0
E/K 27845 Fn3-90 80 rs751068189 0.447 0.566 0.02 N 0.38 0.3 0.206339911435 gnomAD-2.1.1 4.07E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.95E-06 0
E/K 27845 Fn3-90 80 rs751068189 0.447 0.566 0.02 N 0.38 0.3 0.206339911435 gnomAD-4.0.0 1.59911E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86638E-06 0 0
E/K 27941 Fn3-91 79 rs545954394 0.3667 0.878 0.992 N 0.466 0.355 0.36453787251 gnomAD-2.1.1 2.42E-05 None None None None N None 0 5.81E-05 None 0 0 None 0 None 0 3.57E-05 0
E/K 27941 Fn3-91 79 rs545954394 0.3667 0.878 0.992 N 0.466 0.355 0.36453787251 gnomAD-3.1.2 3.94E-05 None None None None N None 2.41E-05 1.96567E-04 0 0 0 None 0 0 2.94E-05 0 0
E/K 27941 Fn3-91 79 rs545954394 0.3667 0.878 0.992 N 0.466 0.355 0.36453787251 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
E/K 27941 Fn3-91 79 rs545954394 0.3667 0.878 0.992 N 0.466 0.355 0.36453787251 gnomAD-4.0.0 3.78119E-05 None None None None N None 1.33301E-05 8.33973E-05 None 0 0 None 0 0 4.15389E-05 0 9.60676E-05
R/C 28134 Fn3-92 80 rs771002170 0.5938 0.011 1.0 N 0.651 0.424 0.608144913684 gnomAD-2.1.1 3.94E-05 None None None None I None 8.27E-05 1.98615E-04 None 9.72E-05 0 None 0 None 0 0 1.41163E-04
R/C 28134 Fn3-92 80 rs771002170 0.5938 0.011 1.0 N 0.651 0.424 0.608144913684 gnomAD-3.1.2 1.31E-05 None None None None I None 2.41E-05 6.55E-05 0 0 0 None 0 0 0 0 0
R/C 28134 Fn3-92 80 rs771002170 0.5938 0.011 1.0 N 0.651 0.424 0.608144913684 gnomAD-4.0.0 1.67469E-05 None None None None I None 2.6738E-05 1.50311E-04 None 3.38203E-05 2.23354E-05 None 1.56436E-05 0 5.93767E-06 2.19746E-05 6.41169E-05
R/H 28134 Fn3-92 80 rs777785413 0.434 -0.656 0.997 N 0.514 0.398 0.299427821978 gnomAD-2.1.1 1.21E-05 None None None None I None 0 2.91E-05 None 0 0 None 3.29E-05 None 4.68E-05 0 0
R/H 28134 Fn3-92 80 rs777785413 0.434 -0.656 0.997 N 0.514 0.398 0.299427821978 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/H 28134 Fn3-92 80 rs777785413 0.434 -0.656 0.997 N 0.514 0.398 0.299427821978 gnomAD-4.0.0 6.82345E-06 None None None None I None 1.33633E-05 3.34124E-05 None 0 0 None 1.56411E-05 0 3.3932E-06 2.19891E-05 1.60282E-05
R/L 28134 Fn3-92 80 rs777785413 0.7585 0.581 0.954 N 0.483 0.417 0.481543764896 gnomAD-2.1.1 8.08E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.79E-05 0
R/L 28134 Fn3-92 80 rs777785413 0.7585 0.581 0.954 N 0.483 0.417 0.481543764896 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/L 28134 Fn3-92 80 rs777785413 0.7585 0.581 0.954 N 0.483 0.417 0.481543764896 gnomAD-4.0.0 5.58282E-06 None None None None I None 0 0 None 0 0 None 0 0 6.7864E-06 0 1.60282E-05
A/V 28332 Fn3-94 81 None 0.2533 None 0.944 N 0.449 0.201 0.435043484731 gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
K/E 28530 Fn3-95 81 None 0.454 None 0.999 N 0.557 0.39 0.311691414656 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
K/T 28730 Fn3-97 80 rs774912635 0.1735 -0.011 0.988 N 0.558 0.473 0.393471546983 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
K/T 28730 Fn3-97 80 rs774912635 0.1735 -0.011 0.988 N 0.558 0.473 0.393471546983 gnomAD-4.0.0 1.59132E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85819E-06 0 0
E/D 28924 Fn3-98 80 None 0.2507 None 0.941 N 0.376 0.222 0.166414681773 gnomAD-4.0.0 6.84865E-07 None None None None I None 0 0 None 0 0 None 0 0 9.0014E-07 0 0
R/C 29217 Fn3-100 81 rs398124459 0.703 None 0.999 N 0.489 0.486 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 2.07297E-04 0
R/C 29217 Fn3-100 81 rs398124459 0.703 None 0.999 N 0.489 0.486 None gnomAD-4.0.0 9.91457E-06 None None None None I None 0 0 None 0 6.6839E-05 None 0 0 6.78055E-06 3.2941E-05 3.20184E-05
R/H 29217 Fn3-100 81 rs749606240 0.5775 -1.076 0.996 N 0.364 0.336 0.373173300195 gnomAD-2.1.1 3.92E-05 None None None None I None 1.23977E-04 0 None 0 5.12E-05 None 0 None 4E-05 3.9E-05 1.40292E-04
R/H 29217 Fn3-100 81 rs749606240 0.5775 -1.076 0.996 N 0.364 0.336 0.373173300195 gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
R/H 29217 Fn3-100 81 rs749606240 0.5775 -1.076 0.996 N 0.364 0.336 0.373173300195 gnomAD-4.0.0 2.29266E-05 None None None None I None 6.67289E-05 0 None 0 2.22787E-05 None 0 4.93583E-04 1.94938E-05 1.09803E-05 6.40369E-05
R/S 29217 Fn3-100 81 None 0.9772 None 0.846 N 0.519 0.314 0.266843984389 gnomAD-4.0.0 6.84167E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99423E-07 0 0
A/G 29317 Fn3-101 81 rs528557883 0.2 -0.067 0.998 N 0.527 0.326 0.406945738958 gnomAD-2.1.1 4.02E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
A/G 29317 Fn3-101 81 rs528557883 0.2 -0.067 0.998 N 0.527 0.326 0.406945738958 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
A/G 29317 Fn3-101 81 rs528557883 0.2 -0.067 0.998 N 0.527 0.326 0.406945738958 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
A/G 29317 Fn3-101 81 rs528557883 0.2 -0.067 0.998 N 0.527 0.326 0.406945738958 gnomAD-4.0.0 6.56556E-06 None None None None I None 2.40523E-05 0 None 0 0 None 0 0 0 0 0
A/T 29317 Fn3-101 81 None 0.0922 None 0.999 N 0.654 0.254 0.428516003163 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 6.17284E-04 0 0 0
A/T 29713 Fn3-104 81 rs1199888872 0.0992 -0.183 0.998 N 0.415 0.201 0.404870348458 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
A/T 29713 Fn3-104 81 rs1199888872 0.0992 -0.183 0.998 N 0.415 0.201 0.404870348458 gnomAD-3.1.2 1.31E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 29713 Fn3-104 81 rs1199888872 0.0992 -0.183 0.998 N 0.415 0.201 0.404870348458 gnomAD-4.0.0 9.92656E-06 None None None None I None 2.6703E-05 0 None 0 0 None 0 0 9.32494E-06 1.09941E-05 3.20349E-05
E/K 30012 Fn3-106 80 rs796978396 0.2161 None 0.999 N 0.609 0.394 0.367803931526 gnomAD-4.0.0 3.4211E-06 None None None None I None 0 0 None 0 0 None 0 0 4.49726E-06 0 0
R/G 30304 Fn3-108 81 None 0.7813 None 0.98 N 0.587 0.299 0.534668972696 gnomAD-4.0.0 3.19291E-06 None None None None I None 0 0 None 0 0 None 0 0 2.87181E-06 1.43468E-05 0
S/F 30404 Fn3-109 81 None 0.1597 None 0.966 N 0.49 0.29 0.643794017197 gnomAD-4.0.0 1.59575E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86776E-06 0 0
A/V 30501 Fn3-110 80 rs1299510786 0.4118 -0.064 1.0 D 0.627 0.392 0.57733738444 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.61E-05 None 0 None 0 0 0
A/V 30501 Fn3-110 80 rs1299510786 0.4118 -0.064 1.0 D 0.627 0.392 0.57733738444 gnomAD-4.0.0 3.18468E-06 None None None None I None 0 0 None 0 2.77948E-05 None 0 0 2.85974E-06 0 0
K/E 30699 Fn3-111 81 rs1248700593 0.3194 None 0.999 N 0.603 0.432 0.283371740733 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/E 30699 Fn3-111 81 rs1248700593 0.3194 None 0.999 N 0.603 0.432 0.283371740733 gnomAD-4.0.0 6.19682E-06 None None None None I None 0 0 None 0 0 None 0 0 8.47616E-06 0 0
G/D 30901 Fn3-113 81 rs879214233 0.2714 None 0.468 N 0.557 0.205 0.16115917748 gnomAD-3.1.2 1.31E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
G/D 30901 Fn3-113 81 rs879214233 0.2714 None 0.468 N 0.557 0.205 0.16115917748 gnomAD-4.0.0 1.31435E-05 None None None None I None 4.82625E-05 0 None 0 0 None 0 0 0 0 0
E/G 31095 Fn3-114 80 rs1235567368 0.4848 None 0.989 N 0.543 0.537 0.405560941015 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/G 31095 Fn3-114 80 rs1235567368 0.4848 None 0.989 N 0.543 0.537 0.405560941015 gnomAD-4.0.0 2.56201E-06 None None None None I None 0 0 None 0 0 None 0 0 4.7856E-06 0 0
E/K 31095 Fn3-114 80 None 0.3514 None 0.956 N 0.517 0.248 0.275215494804 gnomAD-4.0.0 3.18228E-06 None None None None I None 0 0 None 0 2.77254E-05 None 0 0 0 0 3.02371E-05
D/E 31191 Fn3-115 79 rs965506398 0.1392 0.051 0.928 N 0.354 0.13 0.0551355673512 gnomAD-2.1.1 8.03E-06 None None None None I None 0 5.8E-05 None 0 0 None 0 None 0 0 0
D/E 31191 Fn3-115 79 rs965506398 0.1392 0.051 0.928 N 0.354 0.13 0.0551355673512 gnomAD-4.0.0 6.36422E-06 None None None None I None 0 4.5731E-05 None 0 0 None 0 0 5.71576E-06 0 0
D/Y 31191 Fn3-115 79 None 0.334 None 0.999 N 0.634 0.273 0.542187413537 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/I 31388 Fn3-116 81 None 0.6931 None 0.998 N 0.596 0.407 0.623091695385 gnomAD-4.0.0 1.59618E-06 None None None None I None 0 0 None 0 0 None 1.88807E-05 0 0 0 0
A/D 31488 Fn3-117 81 None 0.4489 None 0.998 N 0.599 0.408 0.577403499239 gnomAD-4.0.0 1.59141E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85879E-06 0 0
K/N 31787 Fn3-119 80 rs1225133278 0.7108 0.173 1.0 N 0.671 0.323 0.232513804876 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
K/N 31787 Fn3-119 80 rs1225133278 0.7108 0.173 1.0 N 0.671 0.323 0.232513804876 gnomAD-4.0.0 2.0526E-06 None None None None I None 0 2.23604E-05 None 0 0 None 0 0 1.79895E-06 0 0
K/T 31787 Fn3-119 80 None 0.3401 None 1.0 N 0.621 0.553 0.364926071151 gnomAD-4.0.0 1.3684E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79895E-06 0 0
V/L 31990 Fn3-121 82 rs727503541 0.1141 0.058 0.013 N 0.169 0.098 0.270889551736 gnomAD-2.1.1 7.14E-06 None None None None I None 0 0 None 9.68E-05 0 None 0 None 0 0 1.40647E-04
V/L 31990 Fn3-121 82 rs727503541 0.1141 0.058 0.013 N 0.169 0.098 0.270889551736 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 2.88351E-04 0 None 0 0 0 0 0
V/L 31990 Fn3-121 82 rs727503541 0.1141 0.058 0.013 N 0.169 0.098 0.270889551736 gnomAD-4.0.0 2.47879E-06 None None None None I None 0 0 None 1.01358E-04 0 None 0 0 0 0 1.60123E-05
V/M 31990 Fn3-121 82 rs727503541 0.0968 -0.186 0.537 N 0.259 0.098 None gnomAD-2.1.1 3.21E-05 None None None None I None 1.23967E-04 0 None 0 1.5383E-04 None 3.27E-05 None 0 1.56E-05 0
V/M 31990 Fn3-121 82 rs727503541 0.0968 -0.186 0.537 N 0.259 0.098 None gnomAD-3.1.2 1.97E-05 None None None None I None 2.41E-05 0 0 0 1.92604E-04 None 0 0 1.47E-05 0 0
V/M 31990 Fn3-121 82 rs727503541 0.0968 -0.186 0.537 N 0.259 0.098 None gnomAD-4.0.0 4.02804E-05 None None None None I None 5.33789E-05 0 None 0 6.01631E-04 None 0 1.64474E-04 2.45814E-05 2.19578E-05 3.20246E-05
I/T 32184 Fn3-122 80 rs952755219 0.3736 None 0.994 N 0.439 0.381 0.689408752455 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
I/T 32184 Fn3-122 80 rs952755219 0.3736 None 0.994 N 0.439 0.381 0.689408752455 gnomAD-4.0.0 6.40505E-06 None None None None I None 0 0 None 0 0 None 0 0 1.19645E-05 0 0
E/K 32282 Fn3-123 81 rs1446694825 0.1805 0.851 0.05 N 0.387 0.132 0.31291088546 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
E/K 32282 Fn3-123 81 rs1446694825 0.1805 0.851 0.05 N 0.387 0.132 0.31291088546 gnomAD-4.0.0 3.19332E-06 None None None None I None 0 2.28885E-05 None 0 0 None 0 0 2.87241E-06 0 0
R/C 32479 Fn3-124 81 rs200148139 0.9081 -0.281 1.0 N 0.747 0.483 0.771612649732 gnomAD-2.1.1 8.09E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.79E-05 0
R/C 32479 Fn3-124 81 rs200148139 0.9081 -0.281 1.0 N 0.747 0.483 0.771612649732 gnomAD-4.0.0 4.79196E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29805E-06 0 0
R/H 32479 Fn3-124 81 rs369845358 0.7441 -1.108 1.0 N 0.712 0.436 None gnomAD-2.1.1 6.11E-05 None None None None I None 5.41983E-04 2.84E-05 None 0 0 None 0 None 0 1.57E-05 1.41363E-04
R/H 32479 Fn3-124 81 rs369845358 0.7441 -1.108 1.0 N 0.712 0.436 None gnomAD-3.1.2 1.31492E-04 None None None None I None 4.34447E-04 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
R/H 32479 Fn3-124 81 rs369845358 0.7441 -1.108 1.0 N 0.712 0.436 None 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
R/H 32479 Fn3-124 81 rs369845358 0.7441 -1.108 1.0 N 0.712 0.436 None gnomAD-4.0.0 3.53409E-05 None None None None I None 3.73363E-04 1.00157E-04 None 0 4.47427E-05 None 0 0 1.44137E-05 1.10001E-05 4.80492E-05
R/S 32479 Fn3-124 81 rs200148139 0.9863 -0.345 1.0 N 0.634 0.414 0.44551302605 gnomAD-2.1.1 1.3639E-04 None None None None I None 0 0 None 3.29969E-03 0 None 0 None 0 1.57E-05 2.82167E-04
R/S 32479 Fn3-124 81 rs200148139 0.9863 -0.345 1.0 N 0.634 0.414 0.44551302605 gnomAD-3.1.2 8.55E-05 None None None None I None 0 0 0 3.74424E-03 0 None 0 0 0 0 0
R/S 32479 Fn3-124 81 rs200148139 0.9863 -0.345 1.0 N 0.634 0.414 0.44551302605 gnomAD-4.0.0 9.54818E-05 None None None None I None 0 0 None 3.98864E-03 0 None 0 0 1.95005E-05 0 2.0824E-04
A/T 32680 Fn3-126 81 rs1340922711 0.1465 0.035 0.999 N 0.664 0.332 0.28722502521 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
A/T 32680 Fn3-126 81 rs1340922711 0.1465 0.035 0.999 N 0.664 0.332 0.28722502521 gnomAD-4.0.0 3.19049E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86873E-06 1.43435E-05 0
E/K 33078 Fn3-129 81 rs771047688 0.2137 0.716 0.885 N 0.454 0.249 0.272205846399 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
E/K 33078 Fn3-129 81 rs771047688 0.2137 0.716 0.885 N 0.454 0.249 0.272205846399 gnomAD-4.0.0 1.59165E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85892E-06 0 0
T/I 33371 Fn3-130 82 rs2154137940 0.2323 None 0.062 N 0.433 0.07 0.177238962908 gnomAD-4.0.0 3.1849E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8599E-06 1.43484E-05 0
L/R 33472 Fn3-131 81 None 0.3828 None 0.999 N 0.63 0.524 0.720044110252 gnomAD-4.0.0 1.59154E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85835E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.