Structural position:

  • Domain Type: Fn3
  • Aligned Position: 122
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
E/K 15745 Fn3-1 89 None 0.5543 None 0.997 N 0.816 0.327 0.433600339574 gnomAD-4.0.0 3.42297E-06 None None None None N None 0 0 None 0 0 None 0 0 4.4994E-06 0 0
E/V 15745 Fn3-1 89 rs1559848811 0.3469 None 0.999 N 0.743 0.26 0.565205258651 gnomAD-4.0.0 6.84588E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99875E-07 0 0
A/T 15846 Fn3-2 89 rs770548430 0.0869 None 0.191 N 0.437 0.043 0.152612264143 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 15846 Fn3-2 89 rs770548430 0.0869 None 0.191 N 0.437 0.043 0.152612264143 gnomAD-4.0.0 2.03047E-06 None None None None I None 0 0 None 0 0 None 0 0 2.41022E-06 0 0
A/V 15846 Fn3-2 89 rs1183139911 0.0991 None 0.191 N 0.349 0.154 0.223146558224 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07297E-04 0
A/V 15846 Fn3-2 89 rs1183139911 0.0991 None 0.191 N 0.349 0.154 0.223146558224 gnomAD-4.0.0 2.56663E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.68197E-05 0
Y/C 16142 Fn3-4 88 rs761603067 0.1162 -1.069 1.0 N 0.837 0.335 0.524063890018 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 4.64E-05 0 0
Y/D 16142 Fn3-4 88 None 0.2644 None 0.999 N 0.809 0.545 0.677256655742 gnomAD-4.0.0 1.59393E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86425E-06 0 0
R/I 16242 Fn3-5 88 rs2057021551 0.2008 None 0.303 N 0.474 0.111 0.226586394389 gnomAD-4.0.0 7.01908E-07 None None None None N None 3.0434E-05 0 None 0 0 None 0 0 0 0 0
Q/L 16438 Fn3-6 88 None 0.1097 None 0.915 N 0.595 0.283 0.451599300725 gnomAD-4.0.0 1.59403E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43382E-05 0
E/D 16638 Fn3-8 88 rs2056589440 0.0893 None 0.997 N 0.683 0.109 0.216624796971 gnomAD-4.0.0 1.36967E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79993E-06 0 0
E/G 16738 Fn3-9 88 None 0.8436 None 0.999 D 0.741 0.431 0.454987352986 gnomAD-4.0.0 3.18788E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72505E-06 0 0
E/K 16738 Fn3-9 88 rs148018042 0.8444 0.505 1.0 N 0.82 0.352 None gnomAD-2.1.1 1.46918E-04 None None None None N None 4.14E-05 0 None 0 1.04112E-04 None 2.94426E-04 None 8.01E-05 2.03896E-04 1.41044E-04
E/K 16738 Fn3-9 88 rs148018042 0.8444 0.505 1.0 N 0.82 0.352 None gnomAD-3.1.2 1.84232E-04 None None None None N None 0 1.9667E-04 0 0 1.94932E-04 None 9.42E-05 0 3.23767E-04 2.07383E-04 0
E/K 16738 Fn3-9 88 rs148018042 0.8444 0.505 1.0 N 0.82 0.352 None 1000 genomes 3.99361E-04 None None None None N None 0 0 None None 0 1E-03 None None None 1E-03 None
E/K 16738 Fn3-9 88 rs148018042 0.8444 0.505 1.0 N 0.82 0.352 None gnomAD-4.0.0 2.19528E-04 None None None None N None 4.00267E-05 5.00601E-05 None 0 8.97263E-05 None 4.6897E-05 0 2.67136E-04 1.53809E-04 1.92314E-04
E/V 16839 Fn3-10 89 None 0.5919 None 0.857 N 0.694 0.239 0.427713192076 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
R/P 17235 Fn3-13 89 None 0.744 None 0.969 N 0.517 0.195 0.308904156042 gnomAD-4.0.0 5.49811E-06 None None None None I None 0 0 None 0 0 None 0 0 7.22408E-06 0 0
R/Q 17235 Fn3-13 89 rs573695008 0.2399 0.17 0.76 N 0.515 0.096 0.139678290688 gnomAD-2.1.1 1.52042E-04 None None None None I None 0 6.54264E-04 None 0 9.28409E-04 None 3.35E-05 None 0 0 0
R/Q 17235 Fn3-13 89 rs573695008 0.2399 0.17 0.76 N 0.515 0.096 0.139678290688 gnomAD-3.1.2 6.59E-05 None None None None I None 2.42E-05 6.57E-05 0 0 9.74279E-04 None 0 0 1.47E-05 2.07383E-04 4.78927E-04
R/Q 17235 Fn3-13 89 rs573695008 0.2399 0.17 0.76 N 0.515 0.096 0.139678290688 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
R/Q 17235 Fn3-13 89 rs573695008 0.2399 0.17 0.76 N 0.515 0.096 0.139678290688 gnomAD-4.0.0 4.54258E-05 None None None None I None 1.33636E-05 5.01538E-04 None 0 6.04216E-04 None 0 0 5.95577E-06 5.54004E-05 4.82393E-05
R/W 17235 Fn3-13 89 rs373860372 0.4399 -0.355 0.996 N 0.611 0.272 None gnomAD-2.1.1 1.22E-05 None None None None I None 6.48E-05 0 None 0 0 None 0 None 0 1.8E-05 0
R/W 17235 Fn3-13 89 rs373860372 0.4399 -0.355 0.996 N 0.611 0.272 None gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/W 17235 Fn3-13 89 rs373860372 0.4399 -0.355 0.996 N 0.611 0.272 None gnomAD-4.0.0 9.9522E-06 None None None None I None 0 0 None 3.40832E-05 4.47467E-05 None 0 0 1.10576E-05 0 0
V/A 17458 Fn3-14 90 rs760430370 0.2626 -1.41 0.435 N 0.467 0.224 None gnomAD-2.1.1 1.81E-05 None None None None N None 0 2.86E-05 None 0 0 None 0 None 0 3.17E-05 0
V/A 17458 Fn3-14 90 rs760430370 0.2626 -1.41 0.435 N 0.467 0.224 None gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
V/A 17458 Fn3-14 90 rs760430370 0.2626 -1.41 0.435 N 0.467 0.224 None gnomAD-4.0.0 3.47506E-05 None None None None N None 1.33658E-05 0 None 0 0 None 0 0 4.41104E-05 0 4.81062E-05
V/I 17458 Fn3-14 90 rs763928739 0.0677 -0.282 0.01 N 0.248 0.069 0.308904156042 gnomAD-2.1.1 4.08E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.02E-06 0
V/I 17458 Fn3-14 90 rs763928739 0.0677 -0.282 0.01 N 0.248 0.069 0.308904156042 gnomAD-4.0.0 4.78947E-06 None None None None N None 0 0 None 0 0 None 0 0 8.59594E-06 0 0
P/S 17557 Fn3-15 88 rs986749140 0.1304 None 0.651 N 0.524 0.124 0.19670166235 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/S 17557 Fn3-15 88 rs986749140 0.1304 None 0.651 N 0.524 0.124 0.19670166235 gnomAD-4.0.0 1.86965E-06 None None None None I None 0 0 None 0 0 None 0 0 2.55337E-06 0 0
E/A 17850 Fn3-17 87 rs780284047 0.4957 -0.399 0.799 N 0.559 0.272 0.316494231283 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
E/A 17850 Fn3-17 87 rs780284047 0.4957 -0.399 0.799 N 0.559 0.272 0.316494231283 gnomAD-4.0.0 2.05544E-06 None None None None N None 0 0 None 0 0 None 0 0 1.8002E-06 0 1.65942E-05
L/R 17950 Fn3-18 89 rs2054558907 0.4324 None 0.988 N 0.815 0.337 0.602722737475 gnomAD-4.0.0 1.60013E-06 None None None None I None 0 0 None 0 0 None 0 0 2.87527E-06 0 0
K/E 18154 Fn3-19 90 None 0.218 None None N 0.17 0.135 0.21737058555 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 18259 Fn3-20 94 None 0.1617 None 0.919 N 0.561 0.198 0.278143212241 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/H 18362 Fn3-21 91 rs1467267606 0.1958 -0.237 0.412 N 0.339 0.141 0.188950314367 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
D/H 18362 Fn3-21 91 rs1467267606 0.1958 -0.237 0.412 N 0.339 0.141 0.188950314367 gnomAD-4.0.0 1.36916E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31986E-05 0
D/N 18362 Fn3-21 91 None 0.0895 None 0.047 N 0.227 0.099 0.158396225186 gnomAD-4.0.0 6.84578E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99798E-07 0 0
D/Y 18362 Fn3-21 91 None 0.1345 None 0.412 N 0.441 0.191 0.383089235449 gnomAD-4.0.0 1.36916E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7996E-06 0 0
A/S 18672 Fn3-23 94 None 0.0922 None None N 0.153 0.056 0.0551355673512 gnomAD-4.0.0 1.59331E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43386E-05 0
D/N 18872 Fn3-24 89 rs747911018 0.177 -0.084 0.991 N 0.559 0.264 0.434384183301 gnomAD-2.1.1 4.05E-05 None None None None N None 0 3.56017E-04 None 0 0 None 0 None 0 0 0
D/N 18872 Fn3-24 89 rs747911018 0.177 -0.084 0.991 N 0.559 0.264 0.434384183301 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 6.55E-05 0 0 0 None 0 0 0 0 4.77555E-04
D/N 18872 Fn3-24 89 rs747911018 0.177 -0.084 0.991 N 0.559 0.264 0.434384183301 gnomAD-4.0.0 1.25722E-05 None None None None N None 1.40087E-05 2.31406E-04 None 0 0 None 0 0 8.81447E-07 0 1.2059E-04
L/M 18976 Fn3-25 93 rs1333698664 0.0932 -0.706 0.003 N 0.383 0.062 0.168933306366 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
L/M 18976 Fn3-25 93 rs1333698664 0.0932 -0.706 0.003 N 0.383 0.062 0.168933306366 gnomAD-4.0.0 1.36874E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31949E-05 0
L/R 18976 Fn3-25 93 None 0.1666 None 0.437 N 0.628 0.107 0.245101548738 gnomAD-4.0.0 1.59214E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43336E-05 0
E/D 19076 Fn3-26 89 rs1288756593 0.125 -1.066 0.006 N 0.423 0.121 0.243972157842 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/D 19076 Fn3-26 89 rs1288756593 0.125 -1.066 0.006 N 0.423 0.121 0.243972157842 gnomAD-4.0.0 4.10642E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.95878E-05 0
E/K 19076 Fn3-26 89 None 0.2796 None 0.651 N 0.425 0.268 0.265929055128 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 19271 Fn3-27 89 rs2051339525 0.4422 None 0.997 N 0.849 0.428 0.432266382184 gnomAD-4.0.0 1.72222E-06 None None None None N None 0 0 None 0 0 None 0 0 3.08629E-06 0 0
V/A 19567 Fn3-29 89 rs763514219 0.2181 -1.274 0.435 N 0.429 0.186 0.389283895039 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
V/A 19567 Fn3-29 89 rs763514219 0.2181 -1.274 0.435 N 0.429 0.186 0.389283895039 gnomAD-4.0.0 1.02704E-05 None None None None N None 0 0 None 0 0 None 0 3.47464E-04 1.16962E-05 0 0
V/L 19567 Fn3-29 89 None 0.1339 None 0.002 N 0.191 0.188 0.290962096972 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/M 19567 Fn3-29 89 rs1448926202 0.1593 -0.453 0.868 N 0.483 0.152 0.415313616471 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14837E-04 0 None 0 0 None 0 None 0 0 0
V/M 19567 Fn3-29 89 rs1448926202 0.1593 -0.453 0.868 N 0.483 0.152 0.415313616471 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
V/M 19567 Fn3-29 89 rs1448926202 0.1593 -0.453 0.868 N 0.483 0.152 0.415313616471 gnomAD-4.0.0 1.31544E-05 None None None None N None 4.82928E-05 0 None 0 0 None 0 0 0 0 0
H/R 19770 Fn3-31 91 rs762714656 0.1205 -0.337 0.026 N 0.319 0.118 0.170165803431 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
H/R 19770 Fn3-31 91 rs762714656 0.1205 -0.337 0.026 N 0.319 0.118 0.170165803431 gnomAD-4.0.0 1.59194E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85943E-06 0 0
E/K 19964 Fn3-32 88 rs918361300 0.409 None 0.983 N 0.635 0.219 0.298403945805 gnomAD-4.0.0 3.4228E-06 None None None None N None 0 0 None 0 0 None 0 0 2.6991E-06 1.16012E-05 1.65755E-05
T/I 20063 Fn3-33 87 None 0.2038 None 0.999 N 0.787 0.385 0.430351802785 gnomAD-4.0.0 6.84367E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99635E-07 0 0
T/K 20063 Fn3-33 87 None 0.3396 None 0.999 N 0.777 0.439 0.405700215632 gnomAD-4.0.0 2.73747E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59854E-06 0 0
T/R 20063 Fn3-33 87 rs1560220 0.2945 -0.216 0.999 N 0.767 0.398 0.579627256647 gnomAD-2.1.1 1.61E-05 None None None None I None 0 1.16029E-04 None 0 0 None 0 None 0 0 0
T/R 20063 Fn3-33 87 rs1560220 0.2945 -0.216 0.999 N 0.767 0.398 0.579627256647 gnomAD-4.0.0 3.42184E-06 None None None None I None 0 1.11832E-04 None 0 0 None 0 0 0 0 0
D/N 20259 Fn3-34 89 None 0.1019 None 0.958 N 0.669 0.247 0.302793454619 gnomAD-4.0.0 1.59217E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8601E-06 0 0
P/L 20358 Fn3-35 88 rs751194376 0.0886 -0.124 1.0 N 0.791 0.259 0.594283004778 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
P/L 20358 Fn3-35 88 rs751194376 0.0886 -0.124 1.0 N 0.791 0.259 0.594283004778 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/L 20358 Fn3-35 88 rs751194376 0.0886 -0.124 1.0 N 0.791 0.259 0.594283004778 gnomAD-4.0.0 5.5795E-06 None None None None I None 0 0 None 0 0 None 0 3.29381E-04 5.08727E-06 0 1.60154E-05
P/S 20358 Fn3-35 88 None 0.1163 None 1.0 N 0.819 0.309 0.249502417897 gnomAD-4.0.0 1.59266E-06 None None None None I None 0 0 None 0 0 None 1.88281E-05 0 0 0 0
E/Q 20460 Fn3-36 90 None 0.3957 None 0.999 D 0.79 0.279 0.539612970712 gnomAD-4.0.0 1.70076E-06 None None None None N None 0 0 None 0 0 None 0 0 3.01951E-06 0 0
E/K 20655 Fn3-37 87 rs776314797 0.8286 -0.221 1.0 N 0.781 0.391 0.360565625551 gnomAD-2.1.1 2.01E-05 None None None None N None 0 2.9E-05 None 0 0 None 3.27E-05 None 0 2.67E-05 0
E/K 20655 Fn3-37 87 rs776314797 0.8286 -0.221 1.0 N 0.781 0.391 0.360565625551 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
E/K 20655 Fn3-37 87 rs776314797 0.8286 -0.221 1.0 N 0.781 0.391 0.360565625551 gnomAD-4.0.0 4.46266E-05 None None None None N None 5.34102E-05 1.66761E-05 None 0 0 None 0 0 5.25607E-05 4.39223E-05 1.60149E-05
E/Q 20951 Fn3-39 88 None 0.2982 None 0.999 N 0.8 0.228 0.512998934155 gnomAD-4.0.0 4.79083E-06 None None None None N None 0 0 None 0 0 None 0 0 0 8.11632E-05 0
L/F 21051 Fn3-40 89 None 0.091 None 0.002 N 0.142 0.087 0.356690202451 gnomAD-4.0.0 2.1566E-06 None None None None I None 0 0 None 0 0 None 0 0 2.77745E-06 0 0
L/S 21051 Fn3-40 89 None 0.1212 None 0.361 N 0.407 0.099 0.448099371145 gnomAD-4.0.0 1.78861E-06 None None None None I None 0 0 None 0 0 None 1.97543E-05 0 0 0 0
E/K 21158 Fn3-41 95 None 0.1679 None 0.842 N 0.503 0.19 0.251116650651 gnomAD-4.0.0 1.37511E-06 None None None None N None 0 0 None 0 0 None 0 0 9.02757E-07 1.16995E-05 0
D/G 21353 Fn3-42 88 None 0.2276 None 0.392 N 0.813 0.2 0.202086224978 gnomAD-4.0.0 6.84395E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99709E-07 0 0
D/V 21353 Fn3-42 88 None 0.1339 None 0.693 N 0.789 0.23 0.523133305157 gnomAD-4.0.0 3.42198E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59884E-06 0 1.65728E-05
E/A 21454 Fn3-43 89 rs373183196 0.588 -0.67 0.997 N 0.787 0.335 None gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
D/N 22143 Fn3-48 89 None 0.1136 None 0.799 N 0.682 0.225 0.350964488264 gnomAD-4.0.0 6.84453E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99687E-07 0 0
D/E 22245 Fn3-49 90 rs1306264861 0.1291 -0.072 0.003 N 0.229 0.093 0.193865811164 gnomAD-2.1.1 1.22E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.7E-05 0
D/E 22245 Fn3-49 90 rs1306264861 0.1291 -0.072 0.003 N 0.229 0.093 0.193865811164 gnomAD-4.0.0 4.81058E-06 None None None None I None 0 0 None 0 0 None 0 0 6.32269E-06 0 0
D/N 22245 Fn3-49 90 None 0.1249 None 0.682 N 0.557 0.175 0.306053231325 gnomAD-4.0.0 1.37255E-06 None None None None I None 0 0 None 0 0 None 1.87991E-05 0 9.01838E-07 0 0
D/V 22245 Fn3-49 90 rs757282339 0.149 0.467 0.938 N 0.713 0.378 0.450539155747 gnomAD-2.1.1 4.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.99E-06 0
D/V 22245 Fn3-49 90 rs757282339 0.149 0.467 0.938 N 0.713 0.378 0.450539155747 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/V 22245 Fn3-49 90 rs757282339 0.149 0.467 0.938 N 0.713 0.378 0.450539155747 gnomAD-4.0.0 3.86496E-06 None None None None I None 0 0 None 0 0 None 0 0 7.2301E-06 0 0
D/Y 22245 Fn3-49 90 None 0.2386 None 0.979 N 0.788 0.377 0.499727662827 gnomAD-4.0.0 8.92157E-06 None None None None I None 0 0 None 0 0 None 0 0 1.08221E-05 0 1.66218E-05
E/G 22441 Fn3-50 88 rs201223583 0.6692 -0.93 0.999 N 0.695 0.533 None gnomAD-2.1.1 5.24E-05 None None None None N None 6.46E-05 2.9E-05 None 0 0 None 0 None 0 8.92E-05 1.66223E-04
E/G 22441 Fn3-50 88 rs201223583 0.6692 -0.93 0.999 N 0.695 0.533 None gnomAD-3.1.2 5.26E-05 None None None None N None 0 0 0 0 0 None 0 0 1.17696E-04 0 0
E/G 22441 Fn3-50 88 rs201223583 0.6692 -0.93 0.999 N 0.695 0.533 None gnomAD-4.0.0 1.34525E-04 None None None None N None 0 1.66795E-05 None 0 0 None 0 1.64636E-04 1.68718E-04 0 2.56271E-04
E/K 22536 Fn3-51 86 rs371105318 0.1922 0.044 1.0 N 0.8 0.315 None gnomAD-2.1.1 2.15E-05 None None None None N None 0 0 None 0 5.14E-05 None 0 None 0 3.93E-05 0
E/K 22536 Fn3-51 86 rs371105318 0.1922 0.044 1.0 N 0.8 0.315 None gnomAD-3.1.2 5.92E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.17699E-04 0 0
E/K 22536 Fn3-51 86 rs371105318 0.1922 0.044 1.0 N 0.8 0.315 None gnomAD-4.0.0 3.78144E-05 None None None None N None 1.33529E-05 0 None 0 4.46229E-05 None 0 0 4.83262E-05 0 1.60164E-05
L/P 22831 Fn3-53 89 None 0.107 None 0.006 N 0.461 0.168 0.408444019923 gnomAD-4.0.0 6.37048E-06 None None None None I None 0 0 None 0 0 None 0 0 1.14419E-05 0 0
Q/E 23127 Fn3-55 88 rs953796748 0.0765 -0.186 0.002 N 0.22 0.097 0.0954503805726 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66223E-04
Q/E 23127 Fn3-55 88 rs953796748 0.0765 -0.186 0.002 N 0.22 0.097 0.0954503805726 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/E 23127 Fn3-55 88 rs953796748 0.0765 -0.186 0.002 N 0.22 0.097 0.0954503805726 gnomAD-4.0.0 5.12706E-06 None None None None N None 0 0 None 0 0 None 0 0 7.18322E-06 0 2.84608E-05
E/K 23227 Fn3-56 89 rs765429292 0.0944 0.793 0.03 N 0.417 0.088 0.259761712551 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/K 23227 Fn3-56 89 rs765429292 0.0944 0.793 0.03 N 0.417 0.088 0.259761712551 gnomAD-4.0.0 1.3686E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99556E-07 1.15974E-05 0
E/Q 23227 Fn3-56 89 rs765429292 0.1108 None 0.002 N 0.212 0.107 0.197625483188 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/Q 23227 Fn3-56 89 rs765429292 0.1108 None 0.002 N 0.212 0.107 0.197625483188 gnomAD-4.0.0 1.85934E-06 None None None None I None 0 0 None 0 0 None 0 0 2.54313E-06 0 0
V/M 23329 Fn3-57 90 None 0.0948 None 0.002 N 0.34 0.019 0.173771789658 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 1.94099E-04 0 None 0 0 0 0 0
E/K 23522 Fn3-58 88 rs561586925 0.4349 -0.34 0.995 N 0.805 0.302 0.476908202251 gnomAD-2.1.1 2.41E-05 None None None None N None 0 8.69E-05 None 0 0 None 0 None 0 8.9E-06 3.31895E-04
E/K 23522 Fn3-58 88 rs561586925 0.4349 -0.34 0.995 N 0.805 0.302 0.476908202251 gnomAD-3.1.2 1.97E-05 None None None None N None 0 1.96515E-04 0 0 0 None 0 0 0 0 0
E/K 23522 Fn3-58 88 rs561586925 0.4349 -0.34 0.995 N 0.805 0.302 0.476908202251 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
E/K 23522 Fn3-58 88 rs561586925 0.4349 -0.34 0.995 N 0.805 0.302 0.476908202251 gnomAD-4.0.0 7.43646E-06 None None None None N None 0 8.33222E-05 None 0 0 None 0 0 4.2385E-06 0 3.20123E-05
T/A 23814 Fn3-60 89 rs1425003858 0.0828 -0.553 0.085 N 0.537 0.085 0.239901079897 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
T/A 23814 Fn3-60 89 rs1425003858 0.0828 -0.553 0.085 N 0.537 0.085 0.239901079897 gnomAD-4.0.0 1.59227E-06 None None None None N None 0 0 None 0 2.77778E-05 None 0 0 0 0 0
T/I 23814 Fn3-60 89 None 0.12 None 0.001 N 0.513 0.112 0.293147016451 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
E/D 24013 Fn3-62 90 rs529670209 0.1272 -0.399 0.006 N 0.163 0.044 0.144782658237 gnomAD-2.1.1 3.93E-05 None None None None N None 0 3.11192E-04 None 0 0 None 0 None 0 0 0
E/D 24013 Fn3-62 90 rs529670209 0.1272 -0.399 0.006 N 0.163 0.044 0.144782658237 gnomAD-3.1.2 1.97E-05 None None None None N None 0 1.96541E-04 0 0 0 None 0 0 0 0 0
E/D 24013 Fn3-62 90 rs529670209 0.1272 -0.399 0.006 N 0.163 0.044 0.144782658237 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
E/D 24013 Fn3-62 90 rs529670209 0.1272 -0.399 0.006 N 0.163 0.044 0.144782658237 gnomAD-4.0.0 9.91653E-06 None None None None N None 1.3334E-05 1.83333E-04 None 0 0 None 0 0 8.47772E-07 0 4.80184E-05
E/Q 24606 Fn3-66 88 rs1466808448 0.3037 -0.563 0.976 N 0.629 0.249 0.279370189704 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 6.50195E-04 None 0 None 0 0 0
E/Q 24606 Fn3-66 88 rs1466808448 0.3037 -0.563 0.976 N 0.629 0.249 0.279370189704 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.93498E-04 None 0 0 0 0 0
E/Q 24606 Fn3-66 88 rs1466808448 0.3037 -0.563 0.976 N 0.629 0.249 0.279370189704 gnomAD-4.0.0 6.57255E-06 None None None None N None 0 0 None 0 1.93498E-04 None 0 0 0 0 0
Q/K 24702 Fn3-67 87 None 0.1239 None 0.393 N 0.247 0.157 0.173771789658 gnomAD-4.0.0 6.8445E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99622E-07 0 0
N/S 24896 Fn3-68 89 None 0.0706 None 0.001 N 0.187 0.153 0.0551355673512 gnomAD-4.0.0 3.42164E-06 None None None None N None 0 0 None 0 0 None 0 0 3.5983E-06 1.15942E-05 0
N/T 24896 Fn3-68 89 rs1708142554 0.0647 None None N 0.059 0.181 0.0920862733494 gnomAD-4.0.0 2.73731E-06 None None None None N None 0 0 None 0 7.57308E-05 None 0 0 8.99575E-07 0 0
K/R 24996 Fn3-69 89 rs1206752183 0.0842 None 0.012 N 0.533 0.078 0.247872288689 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.8226E-04 0
E/G 25095 Fn3-70 90 None 0.2411 None 0.799 N 0.595 0.355 0.336155897331 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 25095 Fn3-70 90 None 0.1868 None 0.799 N 0.563 0.179 0.265929055128 gnomAD-4.0.0 1.59174E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85919E-06 0 0
E/D 25292 Fn3-71 89 rs1707677184 0.2264 None 0.997 N 0.659 0.127 0.530060385853 gnomAD-4.0.0 1.59208E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02663E-05
E/Q 25292 Fn3-71 89 rs1015604651 0.1788 None 0.999 N 0.689 0.228 0.438383285633 gnomAD-4.0.0 1.59211E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02682E-05
P/H 25392 Fn3-72 89 None 0.1159 None 0.162 N 0.395 0.182 0.165133752707 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/E 25494 Fn3-73 90 rs370908118 0.149 -0.417 0.964 N 0.741 0.146 0.202949470691 gnomAD-2.1.1 4.08E-06 None None None None N None 0 0 None 0 5.72E-05 None 0 None 0 0 0
Q/H 25688 Fn3-74 88 rs2154167487 0.1352 None None N 0.089 0.084 0.0762999501168 gnomAD-4.0.0 1.59231E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85999E-06 0 0
Q/R 25688 Fn3-74 88 None 0.0977 None None N 0.067 0.129 0.0297737177859 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
S/C 25784 Fn3-75 87 None 0.1034 None 0.994 N 0.542 0.217 0.356072328145 gnomAD-4.0.0 6.84554E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9976E-07 0 0
S/P 25784 Fn3-75 87 rs1383491099 0.0909 -0.091 0.815 N 0.575 0.176 0.15556083564 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
S/P 25784 Fn3-75 87 rs1383491099 0.0909 -0.091 0.815 N 0.575 0.176 0.15556083564 gnomAD-4.0.0 1.5931E-06 None None None None N None 0 0 None 0 2.78087E-05 None 0 0 0 0 0
E/D 25978 Fn3-76 89 rs1025712241 0.0921 None None N 0.109 0.084 0.0954503805726 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/D 25978 Fn3-76 89 rs1025712241 0.0921 None None N 0.109 0.084 0.0954503805726 gnomAD-4.0.0 6.57886E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47106E-05 0 0
E/G 25978 Fn3-76 89 None 0.2575 None 0.361 N 0.508 0.175 0.326881540566 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/Q 25978 Fn3-76 89 rs767541275 0.1816 0.451 0.361 N 0.541 0.186 0.285698343383 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 1.11346E-04 None 0 None 0 0 0
E/Q 25978 Fn3-76 89 rs767541275 0.1816 0.451 0.361 N 0.541 0.186 0.285698343383 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/Q 25978 Fn3-76 89 rs767541275 0.1816 0.451 0.361 N 0.541 0.186 0.285698343383 gnomAD-4.0.0 7.68984E-06 None None None None N None 0 0 None 0 4.85178E-05 None 0 0 7.18267E-06 1.34034E-05 0
K/N 26078 Fn3-77 89 rs1706533541 0.8302 None 0.986 N 0.705 0.231 0.223847106136 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
K/N 26078 Fn3-77 89 rs1706533541 0.8302 None 0.986 N 0.705 0.231 0.223847106136 gnomAD-4.0.0 6.57531E-06 None None None None N None 2.41313E-05 0 None 0 0 None 0 0 0 0 0
D/N 26177 Fn3-78 90 None 0.0877 None 0.682 N 0.675 0.153 0.177238962908 gnomAD-4.0.0 1.59637E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43686E-05 0
E/G 26374 Fn3-79 89 rs878945480 0.599 None 0.999 N 0.639 0.525 None gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/G 26374 Fn3-79 89 rs878945480 0.599 None 0.999 N 0.639 0.525 None gnomAD-4.0.0 2.03007E-06 None None None None I None 3.49614E-05 0 None 0 0 None 0 0 0 0 0
P/A 26474 Fn3-80 89 rs761511285 0.051 -0.277 0.044 N 0.383 0.227 0.207176502487 gnomAD-2.1.1 8.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
P/A 26474 Fn3-80 89 rs761511285 0.051 -0.277 0.044 N 0.383 0.227 0.207176502487 gnomAD-4.0.0 1.23184E-05 None None None None I None 5.97764E-05 0 None 0 0 None 0 0 1.43926E-05 0 0
E/D 26770 Fn3-82 88 None 0.3507 None 0.004 N 0.434 0.118 0.21279746466 gnomAD-4.0.0 5.47416E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19646E-06 0 0
V/E 26866 Fn3-83 87 None 0.1669 None 0.049 N 0.403 0.248 0.335661160332 gnomAD-4.0.0 1.59174E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43291E-05 0
V/L 26866 Fn3-83 87 rs747456605 0.1112 None None N 0.223 0.07 0.236890367714 gnomAD-4.0.0 6.84291E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99572E-07 0 0
V/M 26866 Fn3-83 87 rs747456605 0.1045 -0.287 0.468 N 0.381 0.044 0.315314060047 gnomAD-2.1.1 1.21E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 1.77E-05 0
V/M 26866 Fn3-83 87 rs747456605 0.1045 -0.287 0.468 N 0.381 0.044 0.315314060047 gnomAD-4.0.0 7.5272E-06 None None None None N None 0 2.23634E-05 None 0 0 None 0 0 8.99572E-06 0 0
D/Y 27060 Fn3-84 89 rs372875889 0.2784 0.305 0.989 N 0.831 0.253 None gnomAD-2.1.1 1.08E-05 None None None None N None 1.24121E-04 0 None 0 0 None 0 None 0 0 0
D/Y 27060 Fn3-84 89 rs372875889 0.2784 0.305 0.989 N 0.831 0.253 None gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
D/Y 27060 Fn3-84 89 rs372875889 0.2784 0.305 0.989 N 0.831 0.253 None gnomAD-4.0.0 3.10168E-06 None None None None N None 5.35103E-05 0 None 0 0 None 1.56426E-05 0 0 0 0
K/N 27160 Fn3-85 89 rs764904296 0.8372 0.17 0.883 N 0.58 0.183 0.181679512989 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.66113E-04
K/Q 27160 Fn3-85 89 rs749955874 0.377 0.203 0.062 N 0.405 0.147 0.141422826196 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.61E-05 None 0 None 0 0 0
K/R 27160 Fn3-85 89 None 0.0945 None 0.518 N 0.607 0.157 0.211220785272 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/A 27259 Fn3-86 90 None 0.1056 None 0.006 N 0.425 0.155 0.293502639404 gnomAD-4.0.0 6.84241E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99473E-07 0 0
D/G 27259 Fn3-86 90 rs1704865005 0.1669 None 0.011 N 0.42 0.182 0.183819452728 gnomAD-4.0.0 6.84241E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
D/V 27259 Fn3-86 90 None 0.1094 None 0.026 N 0.568 0.157 0.461759001683 gnomAD-4.0.0 6.84241E-07 None None None None N None 0 0 None 0 2.5227E-05 None 0 0 0 0 0
E/D 27457 Fn3-87 89 None 0.2556 None 0.813 N 0.515 0.111 0.382925413656 gnomAD-4.0.0 1.36846E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79897E-06 0 0
E/D 27557 Fn3-88 89 rs1276281571 0.0914 None 0.817 N 0.419 0.055 0.187945064343 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/D 27557 Fn3-88 89 rs1276281571 0.0914 None 0.817 N 0.419 0.055 0.187945064343 gnomAD-4.0.0 6.57505E-06 None None None None I None 2.41348E-05 0 None 0 0 None 0 0 0 0 0
E/G 27557 Fn3-88 89 rs1704429643 0.1147 None 0.817 N 0.313 0.182 0.338110398507 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
E/G 27557 Fn3-88 89 rs1704429643 0.1147 None 0.817 N 0.313 0.182 0.338110398507 gnomAD-4.0.0 6.57774E-06 None None None None I None 0 6.56082E-05 None 0 0 None 0 0 0 0 0
E/K 27557 Fn3-88 89 rs1481869771 0.0905 0.707 0.915 N 0.375 0.192 0.306695030598 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/K 27557 Fn3-88 89 rs1481869771 0.0905 0.707 0.915 N 0.375 0.192 0.306695030598 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
E/K 27557 Fn3-88 89 rs1481869771 0.0905 0.707 0.915 N 0.375 0.192 0.306695030598 gnomAD-4.0.0 6.40705E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.70026E-05 0
T/I 27659 Fn3-89 90 rs764624631 0.076 0.124 0.041 N 0.487 0.088 0.282179105231 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/I 27659 Fn3-89 90 rs764624631 0.076 0.124 0.041 N 0.487 0.088 0.282179105231 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
T/I 27659 Fn3-89 90 rs764624631 0.076 0.124 0.041 N 0.487 0.088 0.282179105231 gnomAD-4.0.0 2.56242E-06 None None None None N None 0 1.69492E-05 None 0 0 None 0 0 0 1.34002E-05 0
E/K 27853 Fn3-90 88 None 0.3189 None 0.123 N 0.455 0.252 0.270001397563 gnomAD-4.0.0 1.59873E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86699E-06 0 0
E/K 28538 Fn3-95 89 None 0.3365 None 0.856 N 0.768 0.271 0.345175991111 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/G 28738 Fn3-97 88 None 0.1841 None 0.181 N 0.541 0.148 0.186928172975 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/A 28932 Fn3-98 88 rs1702752207 0.3298 None 0.613 N 0.761 0.277 0.387042434762 gnomAD-4.0.0 1.20035E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31253E-06 0 0
E/A 29028 Fn3-99 87 None 0.3235 None 0.991 N 0.746 0.359 0.355034743287 gnomAD-4.0.0 1.59191E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85855E-06 0 0
D/Y 29225 Fn3-100 89 None 0.6014 None 1.0 N 0.786 0.468 0.733514829897 gnomAD-4.0.0 2.05251E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69827E-06 0 0
E/D 29424 Fn3-102 90 rs9808036 0.0807 None 0.002 N 0.23 0.048 0.0920862733494 gnomAD-4.0.0 3.42122E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49724E-06 0 0
E/K 29424 Fn3-102 90 None 0.1737 None 0.651 N 0.404 0.227 0.210429274316 gnomAD-4.0.0 3.18278E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71598E-06 0 0
E/Q 29424 Fn3-102 90 rs763574979 0.1702 -0.67 0.791 N 0.42 0.128 0.206339911435 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/Q 29424 Fn3-102 90 rs763574979 0.1702 -0.67 0.791 N 0.42 0.128 0.206339911435 gnomAD-4.0.0 1.59139E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
E/A 29621 Fn3-103 89 None 0.2291 None 0.953 N 0.539 0.298 0.440394187108 gnomAD-4.0.0 6.84343E-07 None None None None N None 2.98721E-05 0 None 0 0 None 0 0 0 0 0
E/D 29621 Fn3-103 89 rs750981091 0.2229 -0.772 0.06 D 0.388 0.105 0.374255764437 gnomAD-2.1.1 8.06E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.91E-06 0
E/D 29621 Fn3-103 89 rs750981091 0.2229 -0.772 0.06 D 0.388 0.105 0.374255764437 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
E/D 29621 Fn3-103 89 rs750981091 0.2229 -0.772 0.06 D 0.388 0.105 0.374255764437 gnomAD-4.0.0 1.9213E-05 None None None None N None 0 5.00083E-05 None 0 0 None 0 0 2.11911E-05 0 4.804E-05
E/G 29621 Fn3-103 89 rs1559228678 0.4446 None 0.953 N 0.637 0.356 0.491523185611 gnomAD-4.0.0 6.84343E-07 None None None None N None 0 0 None 0 2.52781E-05 None 0 0 0 0 0
E/V 29621 Fn3-103 89 None 0.1623 None 0.993 N 0.665 0.376 0.57179433898 gnomAD-4.0.0 6.84343E-06 None None None None N None 0 0 None 0 0 None 0 0 8.09555E-06 0 1.65711E-05
E/G 30020 Fn3-106 88 rs1320043628 0.4214 -1.195 0.189 N 0.659 0.382 0.390842690916 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/G 30020 Fn3-106 88 rs1320043628 0.4214 -1.195 0.189 N 0.659 0.382 0.390842690916 gnomAD-4.0.0 2.05263E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31873E-05 1.6564E-05
E/K 30020 Fn3-106 88 rs1699956677 0.3367 None 0.189 N 0.553 0.347 0.316198179892 gnomAD-4.0.0 1.59127E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85812E-06 0 0
T/I 30116 Fn3-107 87 None 0.0885 None None N 0.319 0.136 0.199424873507 gnomAD-4.0.0 1.59132E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85811E-06 0 0
V/D 30312 Fn3-108 89 None 0.1676 None None N 0.47 0.248 0.52186301387 gnomAD-4.0.0 1.59565E-06 None None None None N None 0 0 None 0 0 None 0 0 2.87051E-06 0 0
V/F 30312 Fn3-108 89 rs750742292 0.1428 -0.927 0.087 N 0.49 0.101 0.713165642198 gnomAD-2.1.1 1.07E-05 None None None None N None 1.23865E-04 0 None 0 0 None 0 None 0 0 0
V/F 30312 Fn3-108 89 rs750742292 0.1428 -0.927 0.087 N 0.49 0.101 0.713165642198 gnomAD-3.1.2 3.29E-05 None None None None N None 1.20674E-04 0 0 0 0 None 0 0 0 0 0
V/F 30312 Fn3-108 89 rs750742292 0.1428 -0.927 0.087 N 0.49 0.101 0.713165642198 gnomAD-4.0.0 4.34279E-06 None None None None N None 8.01154E-05 0 None 0 0 None 0 0 0 0 1.60323E-05
V/I 30312 Fn3-108 89 rs750742292 0.0727 -0.302 None N 0.228 0.058 0.388653054685 gnomAD-2.1.1 1.21E-05 None None None None N None 0 8.7E-05 None 0 0 None 0 None 0 0 0
V/I 30312 Fn3-108 89 rs750742292 0.0727 -0.302 None N 0.228 0.058 0.388653054685 gnomAD-4.0.0 2.74019E-06 None None None None N None 0 6.71081E-05 None 0 0 None 0 0 9.007E-07 0 0
D/G 30412 Fn3-109 89 None 0.235 None 0.799 N 0.656 0.26 0.221734844693 gnomAD-4.0.0 1.6231E-06 None None None None I None 5.82208E-05 0 None 0 0 None 0 0 0 0 0
D/N 30412 Fn3-109 89 None 0.1183 None 0.799 N 0.559 0.252 0.232513804876 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
Q/E 30510 Fn3-110 89 None 0.1085 None 0.905 N 0.511 0.218 0.141422826196 gnomAD-4.0.0 1.20034E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31253E-06 0 0
D/A 30707 Fn3-111 89 rs778868795 0.2172 -0.208 0.104 N 0.575 0.189 0.29527378943 gnomAD-2.1.1 8.09E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.8E-05 0
D/A 30707 Fn3-111 89 rs778868795 0.2172 -0.208 0.104 N 0.575 0.189 0.29527378943 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
D/A 30707 Fn3-111 89 rs778868795 0.2172 -0.208 0.104 N 0.575 0.189 0.29527378943 gnomAD-4.0.0 2.23126E-05 None None None None N None 0 0 None 0 0 None 0 0 2.96725E-05 0 1.60138E-05
D/G 30707 Fn3-111 89 rs778868795 0.363 -0.748 0.189 N 0.519 0.199 0.270447802918 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.01E-06 0
D/G 30707 Fn3-111 89 rs778868795 0.363 -0.748 0.189 N 0.519 0.199 0.270447802918 gnomAD-4.0.0 6.84361E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99679E-07 0 0
D/N 30707 Fn3-111 89 rs758300381 0.1578 -0.883 0.189 N 0.529 0.167 0.243398259712 gnomAD-2.1.1 1.08E-05 None None None None N None 0 0 None 0 1.53704E-04 None 0 None 0 0 0
D/N 30707 Fn3-111 89 rs758300381 0.1578 -0.883 0.189 N 0.529 0.167 0.243398259712 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92456E-04 None 0 0 0 0 0
D/N 30707 Fn3-111 89 rs758300381 0.1578 -0.883 0.189 N 0.529 0.167 0.243398259712 gnomAD-4.0.0 3.84449E-06 None None None None N None 0 0 None 0 7.27273E-05 None 0 0 0 0 0
G/D 30808 Fn3-112 90 rs1698362464 0.1464 None 0.004 N 0.327 0.072 0.0666544352282 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
G/D 30808 Fn3-112 90 rs1698362464 0.1464 None 0.004 N 0.327 0.072 0.0666544352282 gnomAD-4.0.0 6.57246E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.07039E-04 0
E/K 30909 Fn3-113 89 rs1486624506 0.1869 None 0.935 N 0.509 0.22 0.241664281697 gnomAD-4.0.0 6.84199E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65662E-05
E/Q 30909 Fn3-113 89 rs1486624506 0.1643 -0.82 0.994 N 0.508 0.171 0.167679373172 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/Q 30909 Fn3-113 89 rs1486624506 0.1643 -0.82 0.994 N 0.508 0.171 0.167679373172 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/Q 30909 Fn3-113 89 rs1486624506 0.1643 -0.82 0.994 N 0.508 0.171 0.167679373172 gnomAD-4.0.0 3.09835E-06 None None None None N None 0 8.33444E-05 None 0 0 None 0 0 0 0 0
E/A 31396 Fn3-116 89 rs768420352 0.21 -0.569 0.997 N 0.791 0.326 0.528308644755 gnomAD-2.1.1 1.1E-05 None None None None N None 0 8.67E-05 None 0 0 None 0 None 0 0 0
E/A 31396 Fn3-116 89 rs768420352 0.21 -0.569 0.997 N 0.791 0.326 0.528308644755 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/A 31396 Fn3-116 89 rs768420352 0.21 -0.569 0.997 N 0.791 0.326 0.528308644755 gnomAD-4.0.0 5.15432E-06 None None None None N None 0 6.8334E-05 None 0 0 None 0 0 0 0 0
E/G 31396 Fn3-116 89 None 0.354 None 0.999 N 0.734 0.351 0.604527667468 gnomAD-4.0.0 1.603E-06 None None None None N None 0 0 None 0 0 None 0 0 2.88281E-06 0 0
E/K 31496 Fn3-117 89 rs769175534 0.6543 -0.12 0.998 N 0.58 0.365 0.327686398923 gnomAD-2.1.1 2.82E-05 None None None None N None 0 2.9E-05 None 0 0 None 3.27E-05 None 4.66E-05 2.67E-05 1.66113E-04
E/K 31496 Fn3-117 89 rs769175534 0.6543 -0.12 0.998 N 0.58 0.365 0.327686398923 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 31496 Fn3-117 89 rs769175534 0.6543 -0.12 0.998 N 0.58 0.365 0.327686398923 gnomAD-4.0.0 1.30175E-05 None None None None N None 0 5.00183E-05 None 0 2.22806E-05 None 0 0 1.01747E-05 2.1964E-05 4.8043E-05
E/Q 31496 Fn3-117 89 None 0.4928 None 1.0 N 0.603 0.253 0.412587454835 gnomAD-4.0.0 6.84448E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99782E-07 0 0
E/Q 31795 Fn3-119 88 None 0.1906 None 0.999 N 0.798 0.164 0.240491677333 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/V 31795 Fn3-119 88 rs1441773765 0.178 0.449 0.999 N 0.769 0.508 0.590258251349 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/V 31795 Fn3-119 88 rs1441773765 0.178 0.449 0.999 N 0.769 0.508 0.590258251349 gnomAD-4.0.0 1.59138E-06 None None None None N None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
E/K 31896 Fn3-120 90 rs745365163 0.1123 0.554 0.256 N 0.483 0.207 0.384584525793 gnomAD-2.1.1 5.12E-05 None None None None N None 0 2.88E-05 None 0 4.63058E-04 None 1.02683E-04 None 0 8E-06 0
E/K 31896 Fn3-120 90 rs745365163 0.1123 0.554 0.256 N 0.483 0.207 0.384584525793 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 3.861E-04 None 0 0 0 0 0
E/K 31896 Fn3-120 90 rs745365163 0.1123 0.554 0.256 N 0.483 0.207 0.384584525793 gnomAD-4.0.0 1.68914E-05 None None None None N None 0 1.68976E-05 None 0 2.24336E-04 None 0 0 3.4208E-06 1.22793E-04 1.61928E-05
E/V 31896 Fn3-120 90 rs774355988 0.1317 0.003 0.303 N 0.595 0.146 0.494838880905 gnomAD-2.1.1 5.37E-05 None None None None N None 0 0 None 0 5.6E-05 None 4.10341E-04 None 0 0 0
E/V 31896 Fn3-120 90 rs774355988 0.1317 0.003 0.303 N 0.595 0.146 0.494838880905 gnomAD-4.0.0 2.00499E-05 None None None None N None 0 0 None 0 2.53807E-05 None 0 0 0 3.30033E-04 0
E/A 31998 Fn3-121 90 rs1181902339 0.1331 -0.089 0.996 N 0.718 0.332 0.377451072189 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
E/A 31998 Fn3-121 90 rs1181902339 0.1331 -0.089 0.996 N 0.718 0.332 0.377451072189 gnomAD-4.0.0 3.18339E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71916E-06 0 0
E/K 31998 Fn3-121 90 rs775585263 0.1332 0.869 0.999 N 0.698 0.302 0.33440975612 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
E/K 31998 Fn3-121 90 rs775585263 0.1332 0.869 0.999 N 0.698 0.302 0.33440975612 gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 1.92753E-04 None 0 0 1.47E-05 2.06954E-04 0
E/K 31998 Fn3-121 90 rs775585263 0.1332 0.869 0.999 N 0.698 0.302 0.33440975612 gnomAD-4.0.0 1.73542E-05 None None None None I None 0 0 None 0 4.45653E-05 None 0 0 1.78028E-05 4.39203E-05 1.60128E-05
E/A 32192 Fn3-122 88 None 0.5081 None 0.99 N 0.79 0.455 0.402614778071 gnomAD-4.0.0 1.5912E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85806E-06 0 0
E/K 32192 Fn3-122 88 rs1286172719 0.6352 None 0.995 N 0.799 0.354 0.432604763906 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/K 32192 Fn3-122 88 rs1286172719 0.6352 None 0.995 N 0.799 0.354 0.432604763906 gnomAD-4.0.0 6.57056E-06 None None None None N None 0 6.5505E-05 None 0 0 None 0 0 0 0 0
E/K 32290 Fn3-123 89 rs1060500512 0.3892 None 0.953 N 0.535 0.285 0.383921772103 gnomAD-4.0.0 1.37408E-06 None None None None I None 0 0 None 0 0 None 0 0 1.80613E-06 0 0
E/Q 32290 Fn3-123 89 None 0.2373 None 0.976 N 0.621 0.174 0.259272394797 gnomAD-4.0.0 6.87038E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.16393E-05 0
R/C 32587 Fn3-125 89 rs1248688465 0.1245 -0.576 1.0 N 0.584 0.245 0.516050471323 gnomAD-2.1.1 1.75E-05 None None None None I None 0 1.1869E-04 None 0 0 None 0 None 0 0 0
R/C 32587 Fn3-125 89 rs1248688465 0.1245 -0.576 1.0 N 0.584 0.245 0.516050471323 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.54E-05 0 0 0 None 0 0 0 0 0
R/C 32587 Fn3-125 89 rs1248688465 0.1245 -0.576 1.0 N 0.584 0.245 0.516050471323 gnomAD-4.0.0 5.16578E-06 None None None None I None 0 7.72798E-05 None 0 0 None 0 0 3.5033E-06 0 0
R/G 32587 Fn3-125 89 rs1248688465 0.1495 None 0.872 N 0.548 0.175 0.415438038341 gnomAD-4.0.0 7.16145E-07 None None None None I None 0 2.74288E-05 None 0 0 None 0 0 0 0 0
R/H 32587 Fn3-125 89 None 0.0855 -1.388 0.998 N 0.505 0.212 None gnomAD-2.1.1 1.97795E-03 None None None None I None 4.01946E-03 1.50859E-03 None 3.44195E-04 0 None 2.17202E-04 None 6.28748E-04 2.98324E-03 1.93254E-03
R/H 32587 Fn3-125 89 None 0.0855 -1.388 0.998 N 0.505 0.212 None gnomAD-3.1.2 3.02369E-03 None None None None I None 4.46709E-03 2.03039E-03 0 2.88351E-04 0 None 4.70898E-04 0 3.41036E-03 0 2.87081E-03
R/H 32587 Fn3-125 89 None 0.0855 -1.388 0.998 N 0.505 0.212 None 1000 genomes 1.59744E-03 None None None None I None 3E-03 1.4E-03 None None 0 3E-03 None None None 0 None
R/H 32587 Fn3-125 89 None 0.0855 -1.388 0.998 N 0.505 0.212 None gnomAD-4.0.0 2.72387E-03 None None None None I None 4.542E-03 2.09774E-03 None 1.41753E-04 0 None 8.74761E-04 1.0118E-03 3.11907E-03 2.28816E-04 2.15143E-03
R/P 32587 Fn3-125 89 rs55704830 0.2117 -0.217 0.99 N 0.575 0.271 None gnomAD-2.1.1 5.87361E-04 None None None None I None 5.60609E-03 3.48136E-04 None 0 0 None 0 None 0 1.21E-05 1.75685E-04
R/P 32587 Fn3-125 89 rs55704830 0.2117 -0.217 0.99 N 0.575 0.271 None gnomAD-3.1.2 1.78792E-03 None None None None I None 6.20563E-03 7.20461E-04 0 0 0 None 0 0 0 0 1.91388E-03
R/P 32587 Fn3-125 89 rs55704830 0.2117 -0.217 0.99 N 0.575 0.271 None 1000 genomes 1.19808E-03 None None None None I None 4.5E-03 0 None None 0 0 None None None 0 None
R/P 32587 Fn3-125 89 rs55704830 0.2117 -0.217 0.99 N 0.575 0.271 None gnomAD-4.0.0 3.40803E-04 None None None None I None 6.39965E-03 5.04992E-04 None 0 0 None 0 0 8.76624E-07 1.2043E-05 4.503E-04
K/T 32883 Fn3-127 89 rs776099498 0.2109 -0.289 0.999 N 0.712 0.465 0.404592120364 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
K/T 32883 Fn3-127 89 rs776099498 0.2109 -0.289 0.999 N 0.712 0.465 0.404592120364 gnomAD-4.0.0 1.59171E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85948E-06 0 0
P/H 32985 Fn3-128 90 rs1387380794 0.3155 -0.24 1.0 N 0.8 0.308 0.547254970357 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
P/H 32985 Fn3-128 90 rs1387380794 0.3155 -0.24 1.0 N 0.8 0.308 0.547254970357 gnomAD-3.1.2 2.63E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
P/H 32985 Fn3-128 90 rs1387380794 0.3155 -0.24 1.0 N 0.8 0.308 0.547254970357 gnomAD-4.0.0 1.30277E-05 None None None None N None 8.01368E-05 0 None 0 0 None 0 0 1.27301E-05 0 0
R/S 33086 Fn3-129 89 None 0.9302 None 0.999 N 0.795 0.338 0.264547087235 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/G 33379 Fn3-130 90 None 0.5405 None 0.999 N 0.754 0.458 0.437420747294 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
E/K 33379 Fn3-130 90 None 0.4304 None 0.997 N 0.835 0.416 0.344251166708 gnomAD-4.0.0 6.84462E-07 None None None None N None 0 0 None 0 2.52232E-05 None 0 0 0 0 0
E/G 33775 Fn3-132 87 None 0.2132 None 0.379 D 0.598 0.207 0.414670632993 gnomAD-4.0.0 1.59109E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85786E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.