Structural position:

  • Domain Type: Fn3
  • Aligned Position: 21
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand B

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
S/G 15675 Fn3-1 19 rs1318161801 0.0822 None 0.002 D 0.337 0.141 0.163833314356 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/G 15675 Fn3-1 19 rs1318161801 0.0822 None 0.002 D 0.337 0.141 0.163833314356 gnomAD-4.0.0 6.58077E-06 None None None None N None 2.41383E-05 0 None 0 0 None 0 0 0 0 0
S/N 15675 Fn3-1 19 rs776932497 0.261 -1.127 0.645 N 0.583 0.207 0.228597637076 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/N 15675 Fn3-1 19 rs776932497 0.261 -1.127 0.645 N 0.583 0.207 0.228597637076 gnomAD-4.0.0 1.59413E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43345E-05 0
S/L 15776 Fn3-2 19 rs745354783 0.1428 -0.216 0.27 N 0.587 0.325 0.437207349437 gnomAD-2.1.1 4.04E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
S/L 15776 Fn3-2 19 rs745354783 0.1428 -0.216 0.27 N 0.587 0.325 0.437207349437 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/L 15776 Fn3-2 19 rs745354783 0.1428 -0.216 0.27 N 0.587 0.325 0.437207349437 gnomAD-4.0.0 6.58311E-06 None None None None N None 2.41441E-05 0 None 0 0 None 0 0 0 0 0
H/R 16073 Fn3-4 19 None 0.1097 None 0.968 N 0.477 0.33 0.293502639404 gnomAD-4.0.0 1.59406E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43394E-05 0
H/Y 16073 Fn3-4 19 rs1343135130 0.1059 0.428 0.982 N 0.471 0.287 0.329282125956 gnomAD-2.1.1 4.03E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
H/Y 16073 Fn3-4 19 rs1343135130 0.1059 0.428 0.982 N 0.471 0.287 0.329282125956 gnomAD-4.0.0 1.59414E-06 None None None None N None 5.68117E-05 0 None 0 0 None 0 0 0 0 0
F/L 16173 Fn3-5 19 None 0.8608 None 0.999 N 0.512 0.436 0.431712495121 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
F/S 16173 Fn3-5 19 rs1576472588 0.4979 None 1.0 N 0.766 0.48 0.744465519958 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/I 16369 Fn3-6 19 None 0.0702 None 0.027 N 0.439 0.038 0.130388298395 gnomAD-4.0.0 1.59318E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86144E-06 0 0
L/P 16369 Fn3-6 19 None 0.9319 None 0.741 N 0.609 0.305 0.735914652579 gnomAD-4.0.0 1.59316E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86146E-06 0 0
T/I 16468 Fn3-7 19 rs1345455396 0.4157 0.176 0.997 N 0.627 0.376 0.480349945188 gnomAD-2.1.1 8.11E-06 None None None None N None 0 5.86E-05 None 0 0 None 0 None 0 0 0
T/I 16468 Fn3-7 19 rs1345455396 0.4157 0.176 0.997 N 0.627 0.376 0.480349945188 gnomAD-4.0.0 4.79693E-06 None None None None N None 0 4.49741E-05 None 0 0 None 0 0 4.50166E-06 0 0
R/S 16569 Fn3-8 19 rs879180534 0.1812 -1.585 None N 0.27 0.195 0.0551355673512 gnomAD-2.1.1 1.79E-05 None None None None N None 0 0 None 0 0 None 0 None 8E-05 2.35E-05 0
R/S 16569 Fn3-8 19 rs879180534 0.1812 -1.585 None N 0.27 0.195 0.0551355673512 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
R/S 16569 Fn3-8 19 rs879180534 0.1812 -1.585 None N 0.27 0.195 0.0551355673512 gnomAD-4.0.0 7.44105E-06 None None None None N None 0 0 None 0 0 None 3.12432E-05 0 8.47994E-06 0 0
D/E 16769 Fn3-10 19 rs757648293 0.4328 -0.869 0.046 N 0.399 0.114 0.202949470691 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
D/E 16769 Fn3-10 19 rs757648293 0.4328 -0.869 0.046 N 0.399 0.114 0.202949470691 gnomAD-4.0.0 2.05495E-06 None None None None N None 2.99437E-05 0 None 0 0 None 0 0 1.80012E-06 0 0
D/G 16769 Fn3-10 19 rs1233925811 0.74 -1.21 0.046 N 0.414 0.287 0.204665344411 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
D/N 16769 Fn3-10 19 None 0.2732 None 0.982 N 0.587 0.3 0.325263233342 gnomAD-4.0.0 4.10997E-06 None None None None N None 0 0 None 0 0 None 0 0 5.40043E-06 0 0
A/T 16870 Fn3-11 19 None 0.0946 None 0.379 N 0.563 0.146 0.269111216191 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
L/H 17387 Fn3-14 19 rs2154197942 0.1945 None 0.915 N 0.601 0.355 0.736726114388 gnomAD-4.0.0 1.36983E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79973E-06 0 0
E/K 17587 Fn3-16 19 rs1271096467 0.1749 -1.146 0.22 N 0.421 0.239 0.222439326576 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14732E-04 0 None 0 0 None 0 None 0 0 0
E/K 17587 Fn3-16 19 rs1271096467 0.1749 -1.146 0.22 N 0.421 0.239 0.222439326576 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/K 17587 Fn3-16 19 rs1271096467 0.1749 -1.146 0.22 N 0.421 0.239 0.222439326576 gnomAD-4.0.0 6.58068E-06 None None None None N None 2.41476E-05 0 None 0 0 None 0 0 0 0 0
L/V 17782 Fn3-17 19 rs1178247710 0.1909 -1.366 0.704 N 0.482 0.1 0.422883881359 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
L/V 17782 Fn3-17 19 rs1178247710 0.1909 -1.366 0.704 N 0.482 0.1 0.422883881359 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/V 17782 Fn3-17 19 rs1178247710 0.1909 -1.366 0.704 N 0.482 0.1 0.422883881359 gnomAD-4.0.0 6.20081E-06 None None None None N None 0 0 None 0 0 None 0 0 8.47969E-06 0 0
S/L 18290 Fn3-21 19 None 0.1394 None 0.062 N 0.567 0.317 0.426551566703 gnomAD-4.0.0 1.62226E-06 None None None None N None 0 0 None 0 0 None 0 0 2.9099E-06 0 0
H/P 18597 Fn3-23 19 None 0.5346 -0.813 0.094 N 0.484 0.302 0.341460817117 gnomAD-2.1.1 4.41E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.86081E-04
H/P 18597 Fn3-23 19 None 0.5346 -0.813 0.094 N 0.484 0.302 0.341460817117 gnomAD-4.0.0 1.65553E-06 None None None None N None 0 2.45821E-05 None 0 0 None 0 0 0 0 0
H/Q 18597 Fn3-23 19 None 0.1477 None 0.049 N 0.373 0.128 0.0551355673512 gnomAD-4.0.0 6.94644E-07 None None None None N None 0 0 None 0 0 None 0 0 9.07947E-07 0 0
H/R 18597 Fn3-23 19 rs748143013 0.123 -1.214 0.025 N 0.316 0.195 0.154104182512 gnomAD-2.1.1 8.82E-06 None None None None N None 0 0 None 0 1.15101E-04 None 0 None 0 0 0
H/R 18597 Fn3-23 19 rs748143013 0.123 -1.214 0.025 N 0.316 0.195 0.154104182512 gnomAD-4.0.0 3.31106E-06 None None None None N None 0 0 None 0 5.59879E-05 None 0 0 0 0 0
H/Y 18597 Fn3-23 19 rs1285092776 0.1067 0.473 0.202 N 0.43 0.101 0.235664433957 gnomAD-2.1.1 4.41E-06 None None None None N None 0 3.16E-05 None 0 0 None 0 None 0 0 0
H/Y 18597 Fn3-23 19 rs1285092776 0.1067 0.473 0.202 N 0.43 0.101 0.235664433957 gnomAD-4.0.0 4.96806E-06 None None None None N None 5.96872E-05 2.46002E-05 None 0 0 None 0 0 2.95534E-06 0 0
T/I 18902 Fn3-25 19 None 0.3222 None 1.0 N 0.725 0.422 0.538283067721 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
D/A 19006 Fn3-26 19 rs747343924 0.4713 -0.189 0.989 N 0.564 0.412 None gnomAD-2.1.1 8.21E-06 None None None None N None 1.3031E-04 0 None 0 0 None 0 None 0 0 0
D/A 19006 Fn3-26 19 rs747343924 0.4713 -0.189 0.989 N 0.564 0.412 None gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
D/A 19006 Fn3-26 19 rs747343924 0.4713 -0.189 0.989 N 0.564 0.412 None gnomAD-4.0.0 3.10847E-06 None None None None N None 5.37158E-05 0 None 0 0 None 0 0 0 0 1.60596E-05
D/E 19006 Fn3-26 19 rs780515211 0.3495 -0.751 0.333 N 0.268 0.122 0.165133752707 gnomAD-2.1.1 7.27E-06 None None None None N None 8.31E-05 0 None 0 0 None 0 None 0 0 0
D/E 19006 Fn3-26 19 rs780515211 0.3495 -0.751 0.333 N 0.268 0.122 0.165133752707 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
D/E 19006 Fn3-26 19 rs780515211 0.3495 -0.751 0.333 N 0.268 0.122 0.165133752707 gnomAD-4.0.0 4.97362E-06 None None None None N None 2.68658E-05 0 None 0 0 None 0 0 5.09085E-06 0 0
D/G 19006 Fn3-26 19 rs747343924 0.6936 -0.603 0.994 N 0.547 0.413 0.326881540566 gnomAD-2.1.1 4.1E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.98E-06 0
D/G 19006 Fn3-26 19 rs747343924 0.6936 -0.603 0.994 N 0.547 0.413 0.326881540566 gnomAD-4.0.0 7.55246E-06 None None None None N None 3.0259E-05 0 None 0 0 None 0 0 9.00414E-06 0 0
T/I 19302 Fn3-28 19 None 0.1876 None 0.117 N 0.701 0.119 0.187945064343 gnomAD-4.0.0 1.59357E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02737E-05
T/P 19302 Fn3-28 19 rs2051000706 0.8313 None 0.117 N 0.681 0.239 0.112648838833 gnomAD-3.1.2 1.31E-05 None None None None N None 4.82E-05 0 0 0 0 None 0 0 0 0 0
T/P 19302 Fn3-28 19 rs2051000706 0.8313 None 0.117 N 0.681 0.239 0.112648838833 gnomAD-4.0.0 3.8478E-06 None None None None N None 5.07666E-05 0 None 0 0 None 0 0 0 0 0
L/S 19597 Fn3-30 19 rs777654240 0.2404 -2.524 0.997 N 0.781 0.382 0.570720304676 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
L/S 19597 Fn3-30 19 rs777654240 0.2404 -2.524 0.997 N 0.781 0.382 0.570720304676 gnomAD-4.0.0 1.59238E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4334E-05 0
L/V 19597 Fn3-30 19 rs201013593 0.0785 -1.551 0.117 N 0.413 0.099 0.321672782286 gnomAD-2.1.1 5.63E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.24327E-04 0
L/V 19597 Fn3-30 19 rs201013593 0.0785 -1.551 0.117 N 0.413 0.099 0.321672782286 gnomAD-4.0.0 1.1635E-05 None None None None N None 0 0 None 0 0 None 0 0 1.52934E-05 0 0
D/A 19698 Fn3-31 19 rs878974246 0.2965 None 0.027 N 0.617 0.224 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/A 19698 Fn3-31 19 rs878974246 0.2965 None 0.027 N 0.617 0.224 None gnomAD-4.0.0 4.9587E-06 None None None None N None 0 0 None 0 0 None 0 0 6.78187E-06 0 0
D/H 19698 Fn3-31 19 rs397517642 0.3702 -1.061 0.705 N 0.665 0.284 0.264081493735 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66003E-04
D/H 19698 Fn3-31 19 rs397517642 0.3702 -1.061 0.705 N 0.665 0.284 0.264081493735 gnomAD-4.0.0 6.84343E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65673E-05
D/N 19698 Fn3-31 19 None 0.1558 -0.858 0.426 N 0.607 0.254 0.21279746466 gnomAD-2.1.1 1.21E-05 None None None None N None 0 2.9E-05 None 0 5.6E-05 None 0 None 0 8.91E-06 0
D/N 19698 Fn3-31 19 None 0.1558 -0.858 0.426 N 0.607 0.254 0.21279746466 gnomAD-4.0.0 6.84343E-06 None None None None N None 2.98954E-05 2.23784E-05 None 0 5.04974E-05 None 0 0 4.49788E-06 1.15958E-05 0
D/Y 19698 Fn3-31 19 rs397517642 0.2523 -0.621 0.879 N 0.72 0.302 0.298403945805 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 8.91E-06 0
D/Y 19698 Fn3-31 19 rs397517642 0.2523 -0.621 0.879 N 0.72 0.302 0.298403945805 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 4.78469E-04
D/Y 19698 Fn3-31 19 rs397517642 0.2523 -0.621 0.879 N 0.72 0.302 0.298403945805 gnomAD-4.0.0 9.29797E-06 None None None None N None 0 0 None 0 0 None 0 0 7.6296E-06 4.3928E-05 3.20256E-05
Y/C 19895 Fn3-32 19 rs1355833226 0.2217 None 1.0 N 0.695 0.462 None gnomAD-2.1.1 4.1E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.1E-06 0
Y/C 19895 Fn3-32 19 rs1355833226 0.2217 None 1.0 N 0.695 0.462 None gnomAD-4.0.0 4.78857E-06 None None None None N None 0 0 None 0 0 None 0 0 8.5951E-06 0 0
Y/S 19895 Fn3-32 19 rs1355833226 0.3415 None 0.994 N 0.657 0.521 0.557792573389 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
Y/S 19895 Fn3-32 19 rs1355833226 0.3415 None 0.994 N 0.657 0.521 0.557792573389 gnomAD-4.0.0 2.56883E-06 None None None None N None 3.38455E-05 0 None 0 0 None 0 0 0 0 0
S/F 19995 Fn3-33 19 rs1272769120 0.2278 None 0.976 N 0.603 0.359 0.63713380425 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/F 19995 Fn3-33 19 rs1272769120 0.2278 None 0.976 N 0.603 0.359 0.63713380425 gnomAD-4.0.0 2.03014E-06 None None None None N None 0 0 None 0 0 None 0 0 2.40999E-06 0 0
D/H 20389 Fn3-36 19 rs1410268896 0.8174 None 0.997 N 0.771 0.352 0.354610295913 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/H 20389 Fn3-36 19 rs1410268896 0.8174 None 0.997 N 0.771 0.352 0.354610295913 gnomAD-4.0.0 6.57748E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47128E-05 0 0
T/I 20587 Fn3-37 19 rs757267029 0.1498 None 0.27 N 0.417 0.221 0.330331372229 gnomAD-4.0.0 1.59262E-06 None None None None N None 0 2.28959E-05 None 0 0 None 0 0 0 0 0
T/K 20587 Fn3-37 19 None 0.4839 -0.773 0.642 N 0.506 0.264 0.351180957027 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/K 20587 Fn3-37 19 None 0.4839 -0.773 0.642 N 0.506 0.264 0.351180957027 gnomAD-4.0.0 4.77786E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86002E-06 1.43308E-05 3.02718E-05
T/R 20587 Fn3-37 19 rs757267029 0.4158 -0.582 0.784 D 0.597 0.294 0.539879176108 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 0 9.19118E-04
T/R 20587 Fn3-37 19 rs757267029 0.4158 -0.582 0.784 D 0.597 0.294 0.539879176108 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/R 20587 Fn3-37 19 rs757267029 0.4158 -0.582 0.784 D 0.597 0.294 0.539879176108 gnomAD-4.0.0 6.57704E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47141E-05 0 0
Y/C 20686 Fn3-38 19 rs755470129 0.428 -1.09 0.997 N 0.613 0.304 0.541875726618 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
Y/C 20686 Fn3-38 19 rs755470129 0.428 -1.09 0.997 N 0.613 0.304 0.541875726618 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
Y/C 20686 Fn3-38 19 rs755470129 0.428 -1.09 0.997 N 0.613 0.304 0.541875726618 gnomAD-4.0.0 5.57827E-06 None None None None N None 5.34031E-05 0 None 0 0 None 0 0 3.39095E-06 0 1.60133E-05
Y/H 20686 Fn3-38 19 rs781138196 0.505 -1.676 0.989 N 0.507 0.24 0.360565625551 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
T/A 20882 Fn3-39 19 rs538308579 0.0906 -0.901 0.027 N 0.38 0.043 0.130388298395 gnomAD-2.1.1 2.17E-05 None None None None N None 0 0 None 0 2.07641E-04 None 6.54E-05 None 0 0 0
T/A 20882 Fn3-39 19 rs538308579 0.0906 -0.901 0.027 N 0.38 0.043 0.130388298395 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 1.94175E-04 None 0 0 0 2.07039E-04 0
T/A 20882 Fn3-39 19 rs538308579 0.0906 -0.901 0.027 N 0.38 0.043 0.130388298395 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
T/A 20882 Fn3-39 19 rs538308579 0.0906 -0.901 0.027 N 0.38 0.043 0.130388298395 gnomAD-4.0.0 8.6963E-06 None None None None N None 0 0 None 0 6.71772E-05 None 0 0 0 4.39203E-05 1.12104E-04
T/P 20981 Fn3-40 19 rs1412315320 0.8785 None 1.0 N 0.793 0.548 0.518421792786 gnomAD-4.0.0 1.36876E-06 None None None None N None 0 0 None 3.82995E-05 0 None 0 0 8.99588E-07 0 0
T/I 21082 Fn3-41 19 rs2049445898 0.6042 None 0.998 N 0.637 0.448 0.505518066752 gnomAD-4.0.0 2.75171E-06 None None None None N None 0 0 None 0 0 None 0 0 3.61684E-06 0 0
T/N 21082 Fn3-41 19 rs2049445898 0.3579 None 1.0 N 0.629 0.44 0.458374381611 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
T/N 21082 Fn3-41 19 rs2049445898 0.3579 None 1.0 N 0.629 0.44 0.458374381611 gnomAD-4.0.0 3.11402E-06 None None None None N None 5.34917E-05 1.67308E-05 None 0 0 None 0 0 0 0 0
H/R 21284 Fn3-42 19 rs769740117 0.0919 -0.96 0.669 N 0.425 0.279 0.273503213844 gnomAD-2.1.1 1.63E-05 None None None None N None 0 0 None 1.0008E-04 0 None 0 None 0 2.7E-05 0
H/R 21284 Fn3-42 19 rs769740117 0.0919 -0.96 0.669 N 0.425 0.279 0.273503213844 gnomAD-4.0.0 6.43781E-06 None None None None N None 0 0 None 4.33313E-05 0 None 0 0 7.46118E-06 0 0
H/Y 21284 Fn3-42 19 None 0.0922 None 0.961 N 0.437 0.3 0.326074293725 gnomAD-4.0.0 1.5952E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4353E-05 0
T/I 21384 Fn3-43 19 rs2049065358 0.131 None 0.022 N 0.553 0.124 0.247872288689 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
T/I 21384 Fn3-43 19 rs2049065358 0.131 None 0.022 N 0.553 0.124 0.247872288689 gnomAD-4.0.0 6.5767E-06 None None None None N None 0 6.55222E-05 None 0 0 None 0 0 0 0 0
S/C 21578 Fn3-44 20 None 0.0884 None 0.883 N 0.611 0.246 0.371344866733 gnomAD-4.0.0 1.59234E-06 None None None None N None 0 0 None 0 0 None 0 2.41663E-04 0 0 0
S/P 21578 Fn3-44 20 None 0.8448 None 0.667 N 0.568 0.271 0.186928172975 gnomAD-4.0.0 1.59231E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85997E-06 0 0
F/S 21677 Fn3-45 19 rs760489340 0.5321 -2.519 0.815 N 0.493 0.376 0.669029919475 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
F/S 21677 Fn3-45 19 rs760489340 0.5321 -2.519 0.815 N 0.493 0.376 0.669029919475 gnomAD-4.0.0 3.18524E-06 None None None None N None 0 0 None 0 2.78629E-05 None 0 0 2.86013E-06 0 0
S/F 21775 Fn3-46 19 None 0.4992 None 1.0 N 0.784 0.405 0.667640585422 gnomAD-4.0.0 4.8259E-06 None None None None N None 0 0 None 0 0 None 0 0 8.66371E-06 0 0
S/T 21775 Fn3-46 19 rs2048324718 0.091 None 0.999 N 0.609 0.303 0.315609569513 gnomAD-4.0.0 1.60846E-06 None None None None N None 0 0 None 0 0 None 0 0 2.88757E-06 0 0
M/I 21974 Fn3-47 19 rs751625996 0.2555 -0.378 0.101 N 0.275 0.193 0.365317461125 gnomAD-2.1.1 7.67E-05 None None None None N None 0 0 None 0 0 None 6.21931E-04 None 0 0 0
M/I 21974 Fn3-47 19 rs751625996 0.2555 -0.378 0.101 N 0.275 0.193 0.365317461125 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
M/I 21974 Fn3-47 19 rs751625996 0.2555 -0.378 0.101 N 0.275 0.193 0.365317461125 gnomAD-4.0.0 2.79036E-05 None None None None N None 0 0 None 0 0 None 0 0 0 4.94419E-04 0
M/R 21974 Fn3-47 19 rs373530806 0.3198 0.117 0.213 N 0.437 0.319 0.388010793773 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
M/R 21974 Fn3-47 19 rs373530806 0.3198 0.117 0.213 N 0.437 0.319 0.388010793773 gnomAD-4.0.0 1.36921E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.32035E-05 0
M/T 21974 Fn3-47 19 rs373530806 0.1286 -0.51 0.183 N 0.388 0.304 0.438806408302 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.61E-05 None 0 None 0 0 0
M/T 21974 Fn3-47 19 rs373530806 0.1286 -0.51 0.183 N 0.388 0.304 0.438806408302 gnomAD-4.0.0 2.73842E-06 None None None None N None 0 0 None 0 2.52653E-05 None 0 0 0 1.16017E-05 3.31576E-05
M/V 21974 Fn3-47 19 rs370691527 0.0737 -0.679 0.001 N 0.191 0.271 None gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
M/V 21974 Fn3-47 19 rs370691527 0.0737 -0.679 0.001 N 0.191 0.271 None gnomAD-3.1.2 1.97E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 0 0
M/V 21974 Fn3-47 19 rs370691527 0.0737 -0.679 0.001 N 0.191 0.271 None gnomAD-4.0.0 8.68142E-06 None None None None N None 2.67308E-05 0 None 0 2.23514E-05 None 0 0 7.63215E-06 0 3.20513E-05
S/N 22174 Fn3-49 19 None 0.3156 None 0.892 N 0.531 0.171 0.218112801441 gnomAD-4.0.0 6.87091E-07 None None None None N None 0 0 None 0 0 None 0 0 9.01962E-07 0 0
S/R 22469 Fn3-51 19 rs753623758 0.5443 -0.314 None N 0.299 0.106 0.181679512989 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
S/R 22469 Fn3-51 19 rs753623758 0.5443 -0.314 None N 0.299 0.106 0.181679512989 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/R 22469 Fn3-51 19 rs753623758 0.5443 -0.314 None N 0.299 0.106 0.181679512989 gnomAD-4.0.0 3.09941E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39129E-06 0 1.60149E-05
T/P 22662 Fn3-52 20 rs1484148632 0.7853 None 1.0 N 0.695 0.616 0.478828542108 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/P 22662 Fn3-52 20 rs1484148632 0.7853 None 1.0 N 0.695 0.616 0.478828542108 gnomAD-4.0.0 6.57566E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47119E-05 0 0
S/A 22761 Fn3-53 19 rs2047006376 0.0903 None None N 0.186 0.056 0.0611884634855 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/A 22761 Fn3-53 19 rs2047006376 0.0903 None None N 0.186 0.056 0.0611884634855 gnomAD-4.0.0 6.57566E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47085E-05 0 0
S/F 22761 Fn3-53 19 rs397517676 0.1473 None 0.427 N 0.584 0.178 0.440394187108 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
T/A 23058 Fn3-55 19 rs752304059 0.1194 -1.034 0.919 N 0.475 0.238 0.185906805712 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
T/A 23058 Fn3-55 19 rs752304059 0.1194 -1.034 0.919 N 0.475 0.238 0.185906805712 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/A 23058 Fn3-55 19 rs752304059 0.1194 -1.034 0.919 N 0.475 0.238 0.185906805712 gnomAD-4.0.0 2.48005E-06 None None None None N None 2.67201E-05 0 None 0 0 None 0 0 8.47887E-07 0 1.60226E-05
T/I 23058 Fn3-55 19 None 0.1941 None 0.919 N 0.575 0.397 0.345175991111 gnomAD-4.0.0 3.21706E-05 None None None None N None 0 0 None 0 0 None 0 0 4.22871E-05 0 0
T/S 23058 Fn3-55 19 rs752304059 0.1425 -1.344 0.979 N 0.484 0.28 0.166414681773 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
T/S 23058 Fn3-55 19 rs752304059 0.1425 -1.344 0.979 N 0.484 0.28 0.166414681773 gnomAD-4.0.0 1.30193E-05 None None None None N None 0 0 None 0 0 None 0 0 1.611E-05 0 3.20338E-05
T/A 23157 Fn3-56 19 rs1362003473 0.1727 -0.75 0.958 N 0.462 0.279 0.349429436713 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94175E-04 None 0 0 0 0 0
T/A 23157 Fn3-56 19 rs1362003473 0.1727 -0.75 0.958 N 0.462 0.279 0.349429436713 gnomAD-4.0.0 6.57514E-06 None None None None N None 0 0 None 0 1.94175E-04 None 0 0 0 0 0
S/F 23258 Fn3-57 19 None 0.2732 None 0.939 D 0.623 0.365 0.568250393081 gnomAD-4.0.0 7.11426E-07 None None None None N None 0 0 None 0 0 None 0 0 9.16447E-07 0 0
S/P 23258 Fn3-57 19 None 0.9603 None 0.939 N 0.615 0.367 0.231231049324 gnomAD-4.0.0 3.49355E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.39317E-05 0
S/Y 23258 Fn3-57 19 None 0.2758 None 0.979 N 0.614 0.403 0.597567007519 gnomAD-4.0.0 2.8457E-06 None None None None N None 0 0 None 0 0 None 0 0 3.66579E-06 0 0
T/I 23453 Fn3-58 19 rs1435352674 0.1235 0.074 0.012 N 0.385 0.176 0.255777322467 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.58E-05 None 0 None 0 0 0
T/I 23453 Fn3-58 19 rs1435352674 0.1235 0.074 0.012 N 0.385 0.176 0.255777322467 gnomAD-4.0.0 1.59201E-06 None None None None N None 0 0 None 0 2.77654E-05 None 0 0 0 0 0
T/N 23453 Fn3-58 19 None 0.1874 None 0.947 N 0.616 0.34 0.321393169273 gnomAD-4.0.0 3.18402E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72037E-06 0 0
T/A 23745 Fn3-60 20 rs1280984914 0.1166 -1.46 0.165 N 0.481 0.18 0.192905019026 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
T/N 23745 Fn3-60 20 None 0.1714 -1.256 0.912 N 0.575 0.24 0.294561560033 gnomAD-2.1.1 8.12E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.8E-05 0
T/N 23745 Fn3-60 20 None 0.1714 -1.256 0.912 N 0.575 0.24 0.294561560033 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
T/N 23745 Fn3-60 20 None 0.1714 -1.256 0.912 N 0.575 0.24 0.294561560033 gnomAD-4.0.0 1.98422E-05 None None None None N None 0 1.66934E-05 None 0 0 None 0 0 2.45881E-05 0 3.20461E-05
T/K 23844 Fn3-61 19 None 0.3341 None 0.801 N 0.691 0.278 0.398872588132 gnomAD-4.0.0 1.59218E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85987E-06 0 0
T/P 23844 Fn3-61 19 rs753837961 0.7843 -0.67 0.966 N 0.717 0.417 0.464442853059 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/P 23844 Fn3-61 19 rs753837961 0.7843 -0.67 0.966 N 0.717 0.417 0.464442853059 gnomAD-4.0.0 3.18452E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.86722E-05 0
T/I 23942 Fn3-62 19 None 0.2282 None 0.062 N 0.615 0.246 0.304760801415 gnomAD-4.0.0 6.84317E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65667E-05
T/K 23942 Fn3-62 19 None 0.3024 None 0.062 N 0.589 0.305 0.282575091529 gnomAD-4.0.0 6.84317E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15955E-05 0
V/I 24141 Fn3-63 20 rs1458321606 0.0693 None 0.014 N 0.446 0.041 0.33085137897 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
V/I 24141 Fn3-63 20 rs1458321606 0.0693 None 0.014 N 0.446 0.041 0.33085137897 gnomAD-4.0.0 6.57635E-06 None None None None N None 2.41359E-05 0 None 0 0 None 0 0 0 0 0
V/A 24240 Fn3-64 19 None 0.4023 None 0.349 N 0.452 0.213 0.561790411231 gnomAD-4.0.0 1.86794E-06 None None None None N None 0 0 None 0 0 None 0 0 3.2568E-06 0 0
V/F 24240 Fn3-64 19 rs1345256615 0.4139 -1.403 0.901 N 0.641 0.283 0.672922844732 gnomAD-2.1.1 5.69E-06 None None None None N None 0 4.88E-05 None 0 0 None 0 None 0 0 0
V/F 24240 Fn3-64 19 rs1345256615 0.4139 -1.403 0.901 N 0.641 0.283 0.672922844732 gnomAD-4.0.0 1.87268E-06 None None None None N None 0 0 None 0 0 None 0 0 3.26392E-06 0 0
V/I 24240 Fn3-64 19 rs1345256615 0.0787 -0.738 0.008 N 0.224 0.038 0.417843521124 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14863E-04 0 None 0 0 None 0 None 0 0 0
V/I 24240 Fn3-64 19 rs1345256615 0.0787 -0.738 0.008 N 0.224 0.038 0.417843521124 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
S/A 24341 Fn3-65 19 rs1397935154 0.1281 -0.986 0.309 D 0.467 0.113 None gnomAD-2.1.1 3.19E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
S/A 24341 Fn3-65 19 rs1397935154 0.1281 -0.986 0.309 D 0.467 0.113 None gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/A 24341 Fn3-65 19 rs1397935154 0.1281 -0.986 0.309 D 0.467 0.113 None gnomAD-4.0.0 2.56383E-06 None None None None N None 3.38478E-05 0 None 0 0 None 0 0 0 0 0
S/L 24341 Fn3-65 19 rs568799517 0.1967 None 0.521 N 0.663 0.404 0.563619085548 gnomAD-4.0.0 1.3688E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.31455E-05
T/A 24537 Fn3-66 19 rs1192398039 0.1091 -1.245 0.56 N 0.441 0.213 0.239305524855 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 6.49351E-04 None 0 None 0 0 0
T/A 24537 Fn3-66 19 rs1192398039 0.1091 -1.245 0.56 N 0.441 0.213 0.239305524855 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.93648E-04 None 0 0 0 0 0
T/A 24537 Fn3-66 19 rs1192398039 0.1091 -1.245 0.56 N 0.441 0.213 0.239305524855 gnomAD-4.0.0 6.57367E-06 None None None None N None 0 0 None 0 1.93648E-04 None 0 0 0 0 0
T/I 24537 Fn3-66 19 rs1452164843 0.1122 -0.078 0.997 N 0.536 0.406 0.481321013822 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/I 24537 Fn3-66 19 rs1452164843 0.1122 -0.078 0.997 N 0.536 0.406 0.481321013822 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 24537 Fn3-66 19 rs1452164843 0.1122 -0.078 0.997 N 0.536 0.406 0.481321013822 gnomAD-4.0.0 6.57471E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47076E-05 0 0
S/P 24634 Fn3-67 19 rs1387907795 0.947 -0.259 0.984 N 0.601 0.318 0.390531646278 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
S/P 24634 Fn3-67 19 rs1387907795 0.947 -0.259 0.984 N 0.601 0.318 0.390531646278 gnomAD-4.0.0 1.59208E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85946E-06 0 0
T/S 25024 Fn3-70 19 rs1559397320 0.1087 None 0.958 N 0.413 0.302 0.246773566709 gnomAD-4.0.0 1.59392E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8648E-06 0 0
T/I 25223 Fn3-71 20 rs370070176 0.1025 -0.029 0.004 N 0.424 0.094 None gnomAD-2.1.1 1.11074E-04 None None None None N None 2.48221E-04 2.84E-05 None 0 0 None 7.51978E-04 None 0 0 1.41044E-04
T/I 25223 Fn3-71 20 rs370070176 0.1025 -0.029 0.004 N 0.424 0.094 None gnomAD-3.1.2 4.61E-05 None None None None N None 1.2079E-04 0 0 0 0 None 0 0 0 4.1425E-04 0
T/I 25223 Fn3-71 20 rs370070176 0.1025 -0.029 0.004 N 0.424 0.094 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
T/I 25223 Fn3-71 20 rs370070176 0.1025 -0.029 0.004 N 0.424 0.094 None gnomAD-4.0.0 4.40112E-05 None None None None N None 1.20054E-04 1.66817E-05 None 0 0 None 0 6.60502E-04 0 5.59972E-04 9.60922E-05
I/T 25322 Fn3-72 19 None 0.1783 None None N 0.258 0.14 0.319970858106 gnomAD-4.0.0 2.73724E-06 None None None None N None 0 0 None 0 0 None 0 0 3.5983E-06 0 0
F/L 25423 Fn3-73 19 rs1034189654 0.5254 None 0.08 N 0.27 0.2 0.383089235449 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/P 25716 Fn3-75 19 None 0.9526 None 1.0 N 0.733 0.455 0.339316883193 gnomAD-4.0.0 6.84348E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99614E-07 0 0
T/A 25909 Fn3-76 20 None 0.1295 None 0.919 N 0.541 0.262 0.213573922156 gnomAD-4.0.0 6.84454E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99628E-07 0 0
T/P 25909 Fn3-76 20 None 0.7732 None 0.998 N 0.761 0.459 0.457922657367 gnomAD-4.0.0 1.36891E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79926E-06 0 0
V/A 26008 Fn3-77 19 None 0.1805 None 0.958 N 0.451 0.209 0.596902567841 gnomAD-4.0.0 1.36871E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79918E-06 0 0
V/D 26008 Fn3-77 19 None 0.3385 None 0.998 N 0.817 0.432 0.829967811085 gnomAD-4.0.0 6.84356E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15953E-05 0
V/F 26008 Fn3-77 19 None 0.1517 None 0.988 N 0.759 0.32 0.792114419306 gnomAD-4.0.0 6.8436E-07 None None None None N None 0 0 None 0 2.52321E-05 None 0 0 0 0 0
V/G 26008 Fn3-77 19 rs781254081 0.2547 -2.152 0.994 N 0.769 0.429 0.867461525512 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
V/G 26008 Fn3-77 19 rs781254081 0.2547 -2.152 0.994 N 0.769 0.429 0.867461525512 gnomAD-4.0.0 6.84356E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99591E-07 0 0
V/I 26008 Fn3-77 19 rs748315674 0.0644 -0.777 0.825 N 0.428 0.082 0.553103360211 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
V/I 26008 Fn3-77 19 rs748315674 0.0644 -0.777 0.825 N 0.428 0.082 0.553103360211 gnomAD-4.0.0 2.73744E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59836E-06 0 0
T/I 26106 Fn3-78 19 rs1706489546 0.1642 None 0.852 N 0.463 0.282 0.460352466543 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 26106 Fn3-78 19 rs1706489546 0.1642 None 0.852 N 0.463 0.282 0.460352466543 gnomAD-4.0.0 5.07504E-06 None None None None N None 1.74734E-05 0 None 0 0 None 0 0 4.81985E-06 0 0
T/S 26106 Fn3-78 19 rs768440075 0.1311 -1.432 0.92 N 0.499 0.193 0.223847106136 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
S/C 26305 Fn3-79 20 rs199646089 0.0766 -0.921 0.78 N 0.579 0.215 None gnomAD-2.1.1 6.86E-05 None None None None N None 7.86294E-04 0 None 0 0 None 0 None 0 0 0
S/C 26305 Fn3-79 20 rs199646089 0.0766 -0.921 0.78 N 0.579 0.215 None gnomAD-3.1.2 1.57795E-04 None None None None N None 5.79206E-04 0 0 0 0 None 0 0 0 0 0
S/C 26305 Fn3-79 20 rs199646089 0.0766 -0.921 0.78 N 0.579 0.215 None gnomAD-4.0.0 2.9814E-05 None None None None N None 6.42828E-04 0 None 0 0 None 0 0 0 0 0
T/I 26404 Fn3-80 19 rs786205300 0.3942 0.179 1.0 D 0.788 0.445 0.482792760554 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
T/I 26404 Fn3-80 19 rs786205300 0.3942 0.179 1.0 D 0.788 0.445 0.482792760554 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 26404 Fn3-80 19 rs786205300 0.3942 0.179 1.0 D 0.788 0.445 0.482792760554 gnomAD-4.0.0 1.8594E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54308E-06 0 0
T/N 26404 Fn3-80 19 None 0.703 -1.539 1.0 N 0.68 0.442 0.455173453901 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/N 26404 Fn3-80 19 None 0.703 -1.539 1.0 N 0.68 0.442 0.455173453901 gnomAD-4.0.0 1.36857E-06 None None None None N None 0 2.23684E-05 None 0 0 None 0 0 8.99548E-07 0 0
T/I 26505 Fn3-81 19 rs886042786 0.1473 0.04 0.059 N 0.418 0.25 0.353125101423 gnomAD-2.1.1 7.17E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.57E-05 0
T/I 26505 Fn3-81 19 rs886042786 0.1473 0.04 0.059 N 0.418 0.25 0.353125101423 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 4.38597E-03 0 0 None 0 0 1.47E-05 0 0
T/I 26505 Fn3-81 19 rs886042786 0.1473 0.04 0.059 N 0.418 0.25 0.353125101423 gnomAD-4.0.0 8.98263E-06 None None None None N None 0 0 None 0 0 None 0 0 4.7873E-06 0 2.84608E-05
F/L 26701 Fn3-82 19 rs575784937 0.2257 -1.759 None N 0.154 0.145 0.0806252709748 gnomAD-2.1.1 3.22E-05 None None None None N None 0 0 None 0 0 None 2.61592E-04 None 0 0 0
F/L 26701 Fn3-82 19 rs575784937 0.2257 -1.759 None N 0.154 0.145 0.0806252709748 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06782E-04 0
F/L 26701 Fn3-82 19 rs575784937 0.2257 -1.759 None N 0.154 0.145 0.0806252709748 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
F/L 26701 Fn3-82 19 rs575784937 0.2257 -1.759 None N 0.154 0.145 0.0806252709748 gnomAD-4.0.0 1.40948E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.20627E-04 5.68699E-05
F/S 26701 Fn3-82 19 rs954218807 0.1344 None 0.003 N 0.377 0.109 0.299770980665 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
F/S 26701 Fn3-82 19 rs954218807 0.1344 None 0.003 N 0.377 0.109 0.299770980665 gnomAD-4.0.0 6.57324E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47033E-05 0 0
V/I 26991 Fn3-84 20 rs1362572333 0.0897 -0.489 0.004 N 0.235 0.098 0.411799315854 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
L/P 27090 Fn3-85 19 rs1230737429 0.8542 -1.538 0.56 N 0.605 0.293 0.72796072516 gnomAD-2.1.1 3.18E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
L/P 27090 Fn3-85 19 rs1230737429 0.8542 -1.538 0.56 N 0.605 0.293 0.72796072516 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/P 27090 Fn3-85 19 rs1230737429 0.8542 -1.538 0.56 N 0.605 0.293 0.72796072516 gnomAD-4.0.0 6.57281E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47024E-05 0 0
T/I 27188 Fn3-86 19 None 0.2027 None 0.949 N 0.72 0.312 0.399596177874 gnomAD-4.0.0 1.36877E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79911E-06 0 0
V/A 27487 Fn3-88 19 rs779268775 0.4109 -1.713 0.174 N 0.435 0.281 0.537262924806 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
S/F 27588 Fn3-89 19 None 0.3299 None 0.994 N 0.714 0.425 0.628150982837 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
T/K 27784 Fn3-90 19 None 0.3995 None 0.365 N 0.482 0.215 0.170165803431 gnomAD-4.0.0 6.84433E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99586E-07 0 0
T/M 27784 Fn3-90 19 rs140879454 0.0691 -0.463 0.899 N 0.577 0.194 None gnomAD-2.1.1 3.63E-05 None None None None N None 0 0 None 0 2.81278E-04 None 9.81E-05 None 0 0 1.67112E-04
T/M 27784 Fn3-90 19 rs140879454 0.0691 -0.463 0.899 N 0.577 0.194 None gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 3.86698E-04 None 0 0 1.47E-05 0 0
T/M 27784 Fn3-90 19 rs140879454 0.0691 -0.463 0.899 N 0.577 0.194 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
T/M 27784 Fn3-90 19 rs140879454 0.0691 -0.463 0.899 N 0.577 0.194 None gnomAD-4.0.0 1.36366E-05 None None None None N None 0 0 None 0 1.78859E-04 None 0 0 5.93404E-06 5.49089E-05 3.20307E-05
S/C 28469 Fn3-95 20 rs202040332 0.072 -0.694 0.994 N 0.52 0.273 None gnomAD-2.1.1 2.15129E-03 None None None None N None 0 0 None 3.86772E-04 5.4107E-03 None 5.55665E-04 None 1.63344E-02 3.98687E-04 2.38965E-03
S/C 28469 Fn3-95 20 rs202040332 0.072 -0.694 0.994 N 0.52 0.273 None gnomAD-3.1.2 1.42602E-03 None None None None N None 0 0 0 5.76037E-04 3.47356E-03 None 1.67766E-02 0 2.20504E-04 8.27815E-04 0
S/C 28469 Fn3-95 20 rs202040332 0.072 -0.694 0.994 N 0.52 0.273 None 1000 genomes 9.98403E-04 None None None None N None 0 0 None None 3E-03 1E-03 None None None 1E-03 None
S/C 28469 Fn3-95 20 rs202040332 0.072 -0.694 0.994 N 0.52 0.273 None gnomAD-4.0.0 8.76862E-04 None None None None N None 0 0 None 4.3916E-04 2.83634E-03 None 1.49321E-02 1.64962E-04 1.84777E-04 4.94082E-04 8.96344E-04
S/P 28469 Fn3-95 20 None 0.7262 None 0.939 N 0.527 0.35 0.266843984389 gnomAD-4.0.0 1.3685E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79891E-06 0 0
T/I 28568 Fn3-96 19 rs756726107 0.2112 -0.136 1.0 N 0.699 0.422 0.486779940545 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.91E-06 0
T/I 28568 Fn3-96 19 rs756726107 0.2112 -0.136 1.0 N 0.699 0.422 0.486779940545 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.92901E-04 None 0 0 0 0 0
T/I 28568 Fn3-96 19 rs756726107 0.2112 -0.136 1.0 N 0.699 0.422 0.486779940545 gnomAD-4.0.0 3.09894E-06 None None None None N None 0 0 None 0 2.23115E-05 None 0 0 2.54285E-06 1.09823E-05 0
T/I 29255 Fn3-101 19 None 0.1424 None 0.956 N 0.551 0.324 0.427713192076 gnomAD-4.0.0 6.84179E-07 None None None None N None 2.98704E-05 0 None 0 0 None 0 0 0 0 0
T/S 29255 Fn3-101 19 None 0.1447 None 0.989 N 0.502 0.296 0.223847106136 gnomAD-4.0.0 6.84179E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
S/R 29353 Fn3-102 19 rs1311421658 0.4325 -0.513 None N 0.488 0.18 0.31501682445 gnomAD-2.1.1 1.07E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.35E-05 0
S/R 29353 Fn3-102 19 rs1311421658 0.4325 -0.513 None N 0.488 0.18 0.31501682445 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
S/R 29353 Fn3-102 19 rs1311421658 0.4325 -0.513 None N 0.488 0.18 0.31501682445 gnomAD-4.0.0 9.29609E-06 None None None None N None 0 0 None 0 0 None 0 0 1.27141E-05 0 0
T/A 29552 Fn3-103 20 None 0.1485 None 0.981 N 0.53 0.397 0.308278614506 gnomAD-4.0.0 1.591E-06 None None None None N None 5.65163E-05 0 None 0 0 None 0 0 0 0 0
T/I 29552 Fn3-103 20 rs756935787 0.3175 None 0.999 N 0.755 0.369 0.399596177874 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
T/I 29552 Fn3-103 20 rs756935787 0.3175 None 0.999 N 0.755 0.369 0.399596177874 gnomAD-4.0.0 1.23922E-06 None None None None N None 0 0 None 0 0 None 0 0 8.47568E-07 1.09789E-05 0
T/N 29552 Fn3-103 20 None 0.271 None 0.999 N 0.67 0.337 0.36355261348 gnomAD-4.0.0 6.8416E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99425E-07 0 0
T/S 29552 Fn3-103 20 rs756935787 0.1643 -1.402 0.905 N 0.393 0.259 0.260735089382 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
T/S 29552 Fn3-103 20 rs756935787 0.1643 -1.402 0.905 N 0.393 0.259 0.260735089382 gnomAD-4.0.0 4.78912E-06 None None None None N None 0 0 None 0 0 None 1.87273E-05 0 3.5977E-06 0 3.3129E-05
T/N 29651 Fn3-104 19 None 0.4357 None 1.0 N 0.677 0.39 0.478299402934 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
T/S 29651 Fn3-104 19 None 0.3726 None 0.999 N 0.567 0.289 0.265929055128 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
T/A 29752 Fn3-105 19 rs1181316587 0.2144 -1.138 0.999 N 0.54 0.42 0.325533332567 gnomAD-2.1.1 4.07E-06 None None None None N None 0 0 None 0 0 None 3.34E-05 None 0 0 0
T/A 29752 Fn3-105 19 rs1181316587 0.2144 -1.138 0.999 N 0.54 0.42 0.325533332567 gnomAD-4.0.0 1.59962E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44179E-05 0
I/T 30048 Fn3-107 19 rs760605469 0.0691 -1.768 None N 0.209 0.074 0.236890367714 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
I/T 30048 Fn3-107 19 rs760605469 0.0691 -1.768 None N 0.209 0.074 0.236890367714 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 30048 Fn3-107 19 rs760605469 0.0691 -1.768 None N 0.209 0.074 0.236890367714 gnomAD-4.0.0 1.85892E-06 None None None None N None 0 0 None 0 0 None 0 0 2.5427E-06 0 0
I/F 30243 Fn3-108 20 rs925184690 0.2171 -1.546 0.982 N 0.493 0.318 0.453119318887 gnomAD-2.1.1 1.79E-05 None None None None I None 2.06612E-04 0 None 0 0 None 0 None 0 0 0
I/F 30243 Fn3-108 20 rs925184690 0.2171 -1.546 0.982 N 0.493 0.318 0.453119318887 gnomAD-3.1.2 5.91E-05 None None None None I None 2.17035E-04 0 0 0 0 None 0 0 0 0 0
I/F 30243 Fn3-108 20 rs925184690 0.2171 -1.546 0.982 N 0.493 0.318 0.453119318887 gnomAD-4.0.0 1.05345E-05 None None None None I None 2.2686E-04 0 None 0 0 None 0 0 0 0 0
I/M 30243 Fn3-108 20 rs753176908 0.1218 -1.158 0.991 N 0.523 0.219 0.442466506703 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
I/M 30243 Fn3-108 20 rs753176908 0.1218 -1.158 0.991 N 0.523 0.219 0.442466506703 gnomAD-4.0.0 1.59123E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02352E-05
T/I 30440 Fn3-110 19 rs1446052860 0.51 0.011 1.0 N 0.709 0.437 0.478905595755 gnomAD-4.0.0 1.36871E-06 None None None None N None 0 0 None 0 5.0421E-05 None 0 0 0 0 0
T/P 30440 Fn3-110 19 None 0.9372 None 1.0 N 0.722 0.547 0.500363902356 gnomAD-4.0.0 1.59207E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.0248E-05
T/S 30638 Fn3-111 20 rs1180915423 0.1553 -1.313 0.996 N 0.505 0.368 0.259761712551 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/S 30638 Fn3-111 20 rs1180915423 0.1553 -1.313 0.996 N 0.505 0.368 0.259761712551 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/S 30638 Fn3-111 20 rs1180915423 0.1553 -1.313 0.996 N 0.505 0.368 0.259761712551 gnomAD-4.0.0 6.5722E-06 None None None None N None 0 0 None 0 0 None 0 0 1.46998E-05 0 0
T/N 30737 Fn3-112 19 None 0.4124 None 1.0 N 0.651 0.433 0.509228182784 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
T/A 31034 Fn3-114 19 rs1575474576 0.1618 None 0.999 N 0.546 0.496 0.348324211639 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92976E-04 None 0 0 0 0 0
T/A 31034 Fn3-114 19 rs1575474576 0.1618 None 0.999 N 0.546 0.496 0.348324211639 gnomAD-4.0.0 5.12411E-06 None None None None N None 0 0 None 0 9.69697E-05 None 0 0 0 0 0
V/G 31131 Fn3-115 19 rs1176407616 0.2129 -2.133 0.669 N 0.551 0.197 None gnomAD-2.1.1 1.43E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.13E-05 0
V/G 31131 Fn3-115 19 rs1176407616 0.2129 -2.133 0.669 N 0.551 0.197 None gnomAD-3.1.2 2.63E-05 None None None None N None 0 1.31044E-04 0 0 0 None 0 0 2.94E-05 0 0
V/G 31131 Fn3-115 19 rs1176407616 0.2129 -2.133 0.669 N 0.551 0.197 None gnomAD-4.0.0 1.79706E-05 None None None None N None 0 6.66933E-05 None 0 0 None 0 0 2.03419E-05 0 1.60097E-05
V/I 31131 Fn3-115 19 None 0.0714 None 0.454 N 0.463 0.093 0.379366414296 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
V/A 31327 Fn3-116 20 rs998693629 0.277 -1.425 0.183 N 0.341 0.074 0.368554958709 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
V/A 31327 Fn3-116 20 rs998693629 0.277 -1.425 0.183 N 0.341 0.074 0.368554958709 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
V/A 31327 Fn3-116 20 rs998693629 0.277 -1.425 0.183 N 0.341 0.074 0.368554958709 gnomAD-4.0.0 5.07483E-06 None None None None N None 3.49455E-05 0 None 0 0 None 0 0 2.40985E-06 0 3.40344E-05
V/D 31327 Fn3-116 20 None 0.4542 None 0.213 N 0.553 0.218 0.533856487252 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/L 31327 Fn3-116 20 None 0.1543 None 0.017 N 0.312 0.051 0.302793454619 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 1.01626E-03 None 0 0 None 0 0 0 0 0
S/F 31426 Fn3-117 19 rs369284856 0.2039 -0.292 0.003 N 0.509 0.304 None gnomAD-2.1.1 8.05E-06 None None None None N None 1.29216E-04 0 None 0 0 None 0 None 0 0 0
S/F 31426 Fn3-117 19 rs369284856 0.2039 -0.292 0.003 N 0.509 0.304 None gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/F 31426 Fn3-117 19 rs369284856 0.2039 -0.292 0.003 N 0.509 0.304 None gnomAD-4.0.0 2.56221E-06 None None None None N None 3.38226E-05 0 None 0 0 None 0 0 0 0 0
S/L 31524 Fn3-118 19 rs796571658 0.477 None 0.217 N 0.527 0.33 0.536756967961 gnomAD-4.0.0 3.24899E-06 None None None None N None 0 0 None 0 0 None 0 0 5.87096E-06 0 0
S/P 31524 Fn3-118 19 rs1697398361 0.9936 None 0.999 N 0.658 0.447 0.453772157364 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 31726 Fn3-119 19 rs761422470 0.1857 -1.068 0.998 D 0.473 0.502 0.225215365344 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66058E-04
T/A 31726 Fn3-119 19 rs761422470 0.1857 -1.068 0.998 D 0.473 0.502 0.225215365344 gnomAD-4.0.0 2.73723E-06 None None None None N None 0 0 None 0 0 None 0 3.47222E-04 1.79914E-06 0 0
T/S 31726 Fn3-119 19 None 0.1738 None 0.996 N 0.479 0.401 0.199424873507 gnomAD-4.0.0 1.36861E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79914E-06 0 0
I/L 31825 Fn3-120 19 None 0.1872 None 0.889 N 0.499 0.153 0.650830185303 gnomAD-4.0.0 1.59137E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
I/V 31825 Fn3-120 19 rs1393236297 0.0962 -1.361 0.333 N 0.283 0.135 0.388653054685 gnomAD-2.1.1 1.21E-05 None None None None N None 0 8.69E-05 None 0 0 None 0 None 0 0 0
I/V 31825 Fn3-120 19 rs1393236297 0.0962 -1.361 0.333 N 0.283 0.135 0.388653054685 gnomAD-4.0.0 4.77411E-06 None None None None N None 0 6.85902E-05 None 0 0 None 0 0 0 0 0
T/I 32220 Fn3-123 19 rs727505204 0.2056 0.116 0.031 N 0.379 0.173 0.303453137403 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
T/I 32220 Fn3-123 19 rs727505204 0.2056 0.116 0.031 N 0.379 0.173 0.303453137403 gnomAD-4.0.0 3.42088E-06 None None None None N None 2.98793E-05 0 None 0 0 None 0 0 3.59778E-06 0 0
T/S 32220 Fn3-123 19 None 0.1113 None 0.003 N 0.298 0.103 0.18995819373 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/S 32418 Fn3-124 20 rs771893617 0.1536 -1.55 0.016 N 0.466 0.098 0.173771789658 gnomAD-2.1.1 1.62E-05 None None None None N None 0 0 None 0 0 None 1.30899E-04 None 0 0 0
T/S 32418 Fn3-124 20 rs771893617 0.1536 -1.55 0.016 N 0.466 0.098 0.173771789658 gnomAD-4.0.0 1.43498E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.29029E-04 0
R/K 32814 Fn3-127 20 rs1487649539 0.1946 -1.126 0.997 N 0.493 0.338 0.263612267334 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
R/K 32814 Fn3-127 20 rs1487649539 0.1946 -1.126 0.997 N 0.493 0.338 0.263612267334 gnomAD-4.0.0 6.84205E-07 None None None None N None 0 2.23624E-05 None 0 0 None 0 0 0 0 0
R/T 32814 Fn3-127 20 rs1487649539 0.5965 -0.976 1.0 N 0.763 0.401 0.527356302626 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/T 32814 Fn3-127 20 rs1487649539 0.5965 -0.976 1.0 N 0.763 0.401 0.527356302626 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.9305E-04 None 0 0 0 0 0
R/T 32814 Fn3-127 20 rs1487649539 0.5965 -0.976 1.0 N 0.763 0.401 0.527356302626 gnomAD-4.0.0 1.85912E-06 None None None None N None 0 0 None 0 4.45692E-05 None 0 0 0 1.09801E-05 0
S/C 32915 Fn3-128 20 rs760917372 0.1635 -0.702 0.999 N 0.625 0.293 0.461495907335 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
S/C 32915 Fn3-128 20 rs760917372 0.1635 -0.702 0.999 N 0.625 0.293 0.461495907335 gnomAD-4.0.0 1.36843E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79898E-06 0 0
S/G 32915 Fn3-128 20 rs760917372 0.2274 -1.232 0.026 N 0.235 0.153 0.17948927462 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.77E-05 0
S/G 32915 Fn3-128 20 rs760917372 0.2274 -1.232 0.026 N 0.235 0.153 0.17948927462 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/G 32915 Fn3-128 20 rs760917372 0.2274 -1.232 0.026 N 0.235 0.153 0.17948927462 gnomAD-4.0.0 8.67571E-06 None None None None N None 0 0 None 0 0 None 0 1.31579E-03 5.08574E-06 0 0
S/R 32915 Fn3-128 20 None 0.908 None 0.968 N 0.611 0.274 0.42748209135 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.93751E-06 0 0
V/A 33410 Fn3-131 19 None 0.3283 None 0.999 N 0.643 0.356 0.607509035438 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 33410 Fn3-131 19 rs1691577355 0.0844 None 0.997 N 0.55 0.239 0.59498951386 gnomAD-4.0.0 1.81666E-06 None None None None N None 0 0 None 0 0 None 0 0 3.17154E-06 0 0
N/S 33707 Fn3-132 19 rs1691011936 0.0807 None 0.13 N 0.299 0.117 0.154104182512 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.