Structural position:

  • Domain Type: Fn3
  • Aligned Position: 25
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand B

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
E/K 15679 Fn3-1 23 None 0.2526 None 0.885 N 0.47 0.216 0.306053231325 gnomAD-4.0.0 1.59399E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86257E-06 0 0
E/D 15780 Fn3-2 23 None 0.1832 None 0.434 N 0.263 0.051 0.232513804876 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 15881 Fn3-3 23 rs1437852479 0.2509 None 0.999 N 0.567 0.425 0.29527378943 gnomAD-3.1.2 6.59E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
E/K 15881 Fn3-3 23 rs1437852479 0.2509 None 0.999 N 0.567 0.425 0.29527378943 gnomAD-4.0.0 6.58718E-06 None None None None I None 2.41815E-05 0 None 0 0 None 0 0 0 0 0
D/H 16177 Fn3-5 23 rs1383656849 0.4768 -0.556 0.484 N 0.585 0.373 0.241664281697 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 1.1162E-04 None 0 None 0 0 0
D/H 16177 Fn3-5 23 rs1383656849 0.4768 -0.556 0.484 N 0.585 0.373 0.241664281697 gnomAD-4.0.0 3.18734E-06 None None None None N None 0 0 None 0 5.5534E-05 None 0 0 0 0 0
C/Y 16472 Fn3-7 23 rs766554662 0.2176 -1.053 0.002 N 0.211 0.262 0.429435026966 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
C/Y 16472 Fn3-7 23 rs766554662 0.2176 -1.053 0.002 N 0.211 0.262 0.429435026966 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
C/Y 16472 Fn3-7 23 rs766554662 0.2176 -1.053 0.002 N 0.211 0.262 0.429435026966 gnomAD-4.0.0 3.72256E-06 None None None None N None 1.33701E-05 0 None 1.01695E-04 0 None 0 0 1.69653E-06 0 0
T/P 16573 Fn3-8 23 None 0.2244 None 0.997 D 0.745 0.496 0.401753679984 gnomAD-4.0.0 1.59337E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86187E-06 0 0
T/R 16673 Fn3-9 23 rs373889292 0.4107 None 1.0 N 0.819 0.484 None gnomAD-4.0.0 3.42471E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49959E-06 0 0
E/K 16773 Fn3-10 23 rs879025295 0.5353 None 0.999 N 0.591 0.424 0.328752806141 gnomAD-4.0.0 7.97868E-06 None None None None N None 0 0 None 0 0 None 0 0 1.43237E-05 0 0
K/E 16874 Fn3-11 23 None 0.461 None 0.999 N 0.575 0.444 0.301455362545 gnomAD-4.0.0 6.84504E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99755E-07 0 0
K/T 16874 Fn3-11 23 None 0.4028 None 1.0 N 0.797 0.471 0.392395365052 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 3.66327E-05
E/G 17069 Fn3-12 23 None 0.2782 None 0.994 N 0.672 0.511 0.399596177874 gnomAD-4.0.0 1.59323E-06 None None None None N None 0 0 None 0 0 None 1.88253E-05 0 0 0 0
K/M 17169 Fn3-13 23 rs1167283297 0.5715 None 1.0 N 0.788 0.512 0.442363741745 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/M 17169 Fn3-13 23 rs1167283297 0.5715 None 1.0 N 0.788 0.512 0.442363741745 gnomAD-4.0.0 2.56469E-06 None None None None I None 0 0 None 0 0 None 0 0 4.79148E-06 0 0
N/D 17492 Fn3-15 23 None 0.1467 None 0.896 N 0.521 0.205 0.187945064343 gnomAD-4.0.0 1.60022E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.44421E-05 0
N/K 17492 Fn3-15 23 rs769123120 0.1501 -0.095 0.026 N 0.217 0.127 0.0954503805726 gnomAD-2.1.1 1.24E-05 None None None None N None 0 0 None 0 0 None 1.00496E-04 None 0 0 0
N/K 17492 Fn3-15 23 rs769123120 0.1501 -0.095 0.026 N 0.217 0.127 0.0954503805726 gnomAD-4.0.0 3.42926E-06 None None None None N None 0 0 None 0 0 None 0 0 9.00831E-07 3.50034E-05 1.66041E-05
S/C 17786 Fn3-17 23 rs1060500485 0.2119 -0.292 0.999 N 0.674 0.35 0.374434639691 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/C 17786 Fn3-17 23 rs1060500485 0.2119 -0.292 0.999 N 0.674 0.35 0.374434639691 gnomAD-4.0.0 3.42279E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.8006E-05 0
S/Y 17786 Fn3-17 23 rs1060500485 0.5468 -0.335 0.997 N 0.735 0.364 0.465381546717 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
S/Y 17786 Fn3-17 23 rs1060500485 0.5468 -0.335 0.997 N 0.735 0.364 0.465381546717 gnomAD-4.0.0 9.58382E-06 None None None None N None 0 0 None 0 0 None 0 0 1.25971E-05 0 0
D/E 18087 Fn3-19 23 rs752954226 0.3009 -0.586 1.0 N 0.489 0.292 0.262662153117 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 8.91E-06 0
D/E 18087 Fn3-19 23 rs752954226 0.3009 -0.586 1.0 N 0.489 0.292 0.262662153117 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.95E-05 0 0
D/E 18087 Fn3-19 23 rs752954226 0.3009 -0.586 1.0 N 0.489 0.292 0.262662153117 gnomAD-4.0.0 6.41725E-06 None None None None N None 0 0 None 0 0 None 1.56956E-05 0 9.58966E-06 0 0
D/N 18087 Fn3-19 23 None 0.2804 None 1.0 N 0.621 0.297 0.301122078929 gnomAD-4.0.0 1.36954E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80001E-06 0 0
D/V 18087 Fn3-19 23 None 0.6544 None 1.0 N 0.864 0.506 0.49676076625 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
T/I 18188 Fn3-20 23 None 0.1542 None 0.966 N 0.586 0.276 0.453401982733 gnomAD-4.0.0 1.59411E-06 None None None None N None 0 0 None 0 0 None 1.88352E-05 0 0 0 0
T/N 18188 Fn3-20 23 None 0.0908 None 0.801 N 0.419 0.172 0.346085882481 gnomAD-4.0.0 1.59411E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86395E-06 0 0
T/S 18188 Fn3-20 23 None 0.0951 None 0.625 N 0.443 0.104 0.203808441222 gnomAD-4.0.0 1.59411E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86395E-06 0 0
K/N 18294 Fn3-21 23 rs770482704 0.3664 0.157 0.961 N 0.609 0.223 0.173771789658 gnomAD-2.1.1 4.16E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.27E-06 0
K/N 18294 Fn3-21 23 rs770482704 0.3664 0.157 0.961 N 0.609 0.223 0.173771789658 gnomAD-4.0.0 1.37286E-06 None None None None I None 0 0 None 0 0 None 0 0 1.80289E-06 0 0
K/T 18294 Fn3-21 23 None 0.1703 None 0.248 N 0.32 0.179 0.218112801441 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/N 18501 Fn3-22 23 None 0.638 None 1.0 N 0.701 0.263 0.201204373187 gnomAD-4.0.0 6.8453E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99807E-07 0 0
F/L 18807 Fn3-24 24 rs2052666305 0.151 None None N 0.113 0.121 0.246773566709 gnomAD-4.0.0 1.38371E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80791E-06 0 0
E/K 18906 Fn3-25 23 rs1263513465 0.3738 -0.056 0.978 N 0.547 0.415 0.316788114976 gnomAD-2.1.1 4.1E-06 None None None None I None 0 2.93E-05 None 0 0 None 0 None 0 0 0
E/K 18906 Fn3-25 23 rs1263513465 0.3738 -0.056 0.978 N 0.547 0.415 0.316788114976 gnomAD-4.0.0 6.16957E-06 None None None None I None 0 2.24699E-05 None 0 0 None 0 0 7.2041E-06 0 0
S/A 19010 Fn3-26 23 rs758709446 0.0815 -0.248 0.005 N 0.188 0.051 0.141422826196 gnomAD-2.1.1 4.1E-06 None None None None N None 0 0 None 0 5.74E-05 None 0 None 0 0 0
S/A 19010 Fn3-26 23 rs758709446 0.0815 -0.248 0.005 N 0.188 0.051 0.141422826196 gnomAD-4.0.0 1.60333E-06 None None None None N None 0 0 None 0 2.7908E-05 None 0 0 0 0 0
N/S 19601 Fn3-30 23 None 0.0968 None 0.201 N 0.394 0.162 0.16115917748 gnomAD-4.0.0 1.59227E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43303E-05 0
Q/H 19702 Fn3-31 23 rs1380151837 0.2661 -0.621 0.006 D 0.196 0.127 0.167679373172 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
Q/H 19702 Fn3-31 23 rs1380151837 0.2661 -0.621 0.006 D 0.196 0.127 0.167679373172 gnomAD-4.0.0 3.18388E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71853E-06 0 0
K/E 19899 Fn3-32 23 rs1450922913 0.2164 None 0.969 N 0.523 0.335 0.294206760003 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/E 19899 Fn3-32 23 rs1450922913 0.2164 None 0.969 N 0.523 0.335 0.294206760003 gnomAD-4.0.0 3.10186E-06 None None None None N None 0 0 None 0 0 None 0 0 4.24073E-06 0 0
N/S 19999 Fn3-33 23 rs778293115 0.1178 -0.907 0.716 N 0.447 0.135 0.159798565429 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/S 19999 Fn3-33 23 rs778293115 0.1178 -0.907 0.716 N 0.447 0.135 0.159798565429 gnomAD-4.0.0 4.77692E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.2996E-05 0
E/K 20591 Fn3-37 23 rs1327237859 0.5433 -0.777 0.978 N 0.492 0.382 0.330331372229 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/K 20591 Fn3-37 23 rs1327237859 0.5433 -0.777 0.978 N 0.492 0.382 0.330331372229 gnomAD-4.0.0 1.59264E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43308E-05 0
R/G 20690 Fn3-38 23 None 0.8641 None 1.0 N 0.749 0.344 0.434160288164 gnomAD-4.0.0 6.84331E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9959E-07 0 0
R/L 20690 Fn3-38 23 None 0.7523 None 1.0 N 0.749 0.377 0.547893116657 gnomAD-4.0.0 6.84324E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99582E-07 0 0
R/Q 20690 Fn3-38 23 rs753480368 0.3473 -0.47 1.0 N 0.704 0.328 None gnomAD-2.1.1 8.07E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
R/Q 20690 Fn3-38 23 rs753480368 0.3473 -0.47 1.0 N 0.704 0.328 None gnomAD-4.0.0 1.36865E-05 None None None None N None 0 2.23664E-05 None 0 0 None 0 1.73611E-04 1.0795E-05 4.63854E-05 3.31367E-05
R/W 20690 Fn3-38 23 rs758801935 0.7886 -0.243 1.0 N 0.824 0.39 0.308278614506 gnomAD-2.1.1 8.07E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
R/W 20690 Fn3-38 23 rs758801935 0.7886 -0.243 1.0 N 0.824 0.39 0.308278614506 gnomAD-4.0.0 6.15898E-06 None None None None N None 0 6.71021E-05 None 0 0 None 0 0 4.49795E-06 1.15961E-05 0
D/E 20886 Fn3-39 23 rs1381546881 0.152 -0.618 0.117 N 0.206 0.047 0.151104730317 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
D/E 20886 Fn3-39 23 rs1381546881 0.152 -0.618 0.117 N 0.206 0.047 0.151104730317 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/E 20886 Fn3-39 23 rs1381546881 0.152 -0.618 0.117 N 0.206 0.047 0.151104730317 gnomAD-4.0.0 6.57678E-06 None None None None N None 2.41348E-05 0 None 0 0 None 0 0 0 0 0
D/G 20886 Fn3-39 23 None 0.3485 None 0.977 N 0.689 0.369 0.351614576976 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/N 20886 Fn3-39 23 rs1445324473 0.1606 -1.096 0.993 N 0.671 0.319 0.348983352498 gnomAD-2.1.1 8.16E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 8.93E-06 0
D/N 20886 Fn3-39 23 rs1445324473 0.1606 -1.096 0.993 N 0.671 0.319 0.348983352498 gnomAD-4.0.0 4.80654E-06 None None None None N None 0 2.28906E-05 None 0 0 None 0 0 5.71925E-06 0 0
N/K 20985 Fn3-40 23 None 0.2565 None 0.062 N 0.297 0.104 0.0846915920261 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
G/R 21086 Fn3-41 23 rs755518802 0.458 -0.47 0.994 N 0.676 0.34 0.399596177874 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 3.29E-05 None 0 0 0
G/R 21086 Fn3-41 23 rs755518802 0.458 -0.47 0.994 N 0.676 0.34 0.399596177874 gnomAD-4.0.0 3.20002E-06 None None None None I None 0 0 None 0 0 None 0 0 2.87854E-06 1.43843E-05 0
A/D 21288 Fn3-42 23 rs2049247544 0.1866 None 0.062 N 0.539 0.078 0.268660756437 gnomAD-4.0.0 2.05421E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69946E-06 0 0
A/V 21288 Fn3-42 23 rs2049247544 0.0672 None None N 0.249 0.083 0.232513804876 gnomAD-4.0.0 6.84736E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99819E-07 0 0
L/S 21388 Fn3-43 23 None 0.5654 None 1.0 N 0.835 0.439 0.779518707146 gnomAD-4.0.0 1.59276E-06 None None None None I None 0 2.2876E-05 None 0 0 None 0 0 0 0 0
L/V 21388 Fn3-43 23 None 0.2055 None 0.999 N 0.514 0.209 0.404870348458 gnomAD-4.0.0 6.84484E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15966E-05 0
H/R 21582 Fn3-44 24 rs770805220 0.1175 -0.413 0.959 N 0.442 0.234 0.273938319068 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 9.97E-05 0 None 0 None 0 0 0
H/R 21582 Fn3-44 24 rs770805220 0.1175 -0.413 0.959 N 0.442 0.234 0.273938319068 gnomAD-4.0.0 1.59222E-06 None None None None N None 0 0 None 4.77008E-05 0 None 0 0 0 0 0
D/V 21681 Fn3-45 23 rs192371243 0.3959 0.524 0.97 N 0.725 0.436 None gnomAD-2.1.1 8.06E-06 None None None None N None 0 5.81E-05 None 0 0 None 0 None 0 0 0
D/V 21681 Fn3-45 23 rs192371243 0.3959 0.524 0.97 N 0.725 0.436 None gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
D/V 21681 Fn3-45 23 rs192371243 0.3959 0.524 0.97 N 0.725 0.436 None 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
D/V 21681 Fn3-45 23 rs192371243 0.3959 0.524 0.97 N 0.725 0.436 None gnomAD-4.0.0 2.47946E-06 None None None None N None 0 3.33456E-05 None 0 0 None 0 0 8.47797E-07 0 1.60133E-05
D/Y 21681 Fn3-45 23 None 0.4361 None 0.99 N 0.773 0.337 0.495506531988 gnomAD-4.0.0 1.5925E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43328E-05 0
A/V 21779 Fn3-46 23 rs758250372 0.1593 -0.155 0.379 N 0.425 0.171 0.252681307341 gnomAD-2.1.1 1.47E-05 None None None None N None 0 0 None 0 0 None 0 None 4.07E-05 2.43E-05 0
A/V 21779 Fn3-46 23 rs758250372 0.1593 -0.155 0.379 N 0.425 0.171 0.252681307341 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 9.43E-05 0 1.47E-05 0 0
A/V 21779 Fn3-46 23 rs758250372 0.1593 -0.155 0.379 N 0.425 0.171 0.252681307341 gnomAD-4.0.0 8.70395E-06 None None None None N None 0 0 None 0 0 None 1.56922E-05 0 8.49403E-06 0 4.81881E-05
E/K 21978 Fn3-47 23 None 0.257 None 0.014 N 0.277 0.262 0.180583059064 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/N 22077 Fn3-48 23 None 0.567 None 0.032 N 0.252 0.052 0.0986583533028 gnomAD-4.0.0 6.84686E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99651E-07 0 0
G/D 22178 Fn3-49 23 None 0.6533 None 0.801 N 0.482 0.194 0.230578612272 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
G/S 22178 Fn3-49 23 None 0.1078 None 0.022 N 0.153 0.136 0.141422826196 gnomAD-4.0.0 1.60301E-06 None None None None I None 0 0 None 0 0 None 0 0 2.87606E-06 0 0
G/V 22178 Fn3-49 23 None 0.3001 None 0.801 N 0.557 0.226 0.430239905395 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/E 22473 Fn3-51 23 rs1164219894 0.2567 0.178 0.996 N 0.575 0.371 0.272639205421 gnomAD-4.0.0 2.05323E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69903E-06 0 0
T/N 22863 Fn3-54 23 None 0.1178 None 0.142 N 0.263 0.207 0.229264304666 gnomAD-4.0.0 6.88269E-07 None None None None N None 0 2.283E-05 None 0 0 None 0 0 0 0 0
T/S 22863 Fn3-54 23 None 0.1077 None 0.919 N 0.42 0.207 0.143124449307 gnomAD-4.0.0 4.81741E-06 None None None None N None 0 0 None 0 0 None 0 0 6.32222E-06 0 0
G/C 23262 Fn3-57 23 None 0.2953 None 0.997 N 0.853 0.362 0.354610295913 gnomAD-4.0.0 2.84202E-06 None None None None I None 0 0 None 0 0 None 0 0 2.74815E-06 0 1.72366E-05
G/S 23262 Fn3-57 23 None 0.1198 None 0.085 N 0.365 0.079 0.107399877778 gnomAD-4.0.0 7.10502E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.72366E-05
D/N 23457 Fn3-58 23 None 0.1859 None 0.698 N 0.548 0.232 0.268211541103 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/V 23457 Fn3-58 23 rs535816123 0.5045 0.436 0.919 N 0.722 0.451 0.468834750356 gnomAD-2.1.1 2.82E-05 None None None None I None 0 1.73893E-04 None 0 0 None 0 None 0 8.89E-06 0
D/V 23457 Fn3-58 23 rs535816123 0.5045 0.436 0.919 N 0.722 0.451 0.468834750356 gnomAD-3.1.2 1.32E-05 None None None None I None 0 6.56E-05 0 0 0 None 0 0 1.47E-05 0 0
D/V 23457 Fn3-58 23 rs535816123 0.5045 0.436 0.919 N 0.722 0.451 0.468834750356 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 1E-03 None None None 0 None
D/V 23457 Fn3-58 23 rs535816123 0.5045 0.436 0.919 N 0.722 0.451 0.468834750356 gnomAD-4.0.0 1.53793E-05 None None None None I None 0 1.69509E-04 None 0 0 None 0 0 4.78886E-06 0 0
P/S 23554 Fn3-59 23 None 0.1905 None 0.309 N 0.447 0.135 0.166414681773 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
H/N 23848 Fn3-61 23 rs1171521240 0.0602 0.539 None N 0.198 0.089 0.136095386433 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.66058E-04
H/N 23848 Fn3-61 23 rs1171521240 0.0602 0.539 None N 0.198 0.089 0.136095386433 gnomAD-4.0.0 3.1839E-06 None None None None I None 0 0 None 0 0 None 0 4.83092E-04 0 0 0
H/Q 23848 Fn3-61 23 rs1026649081 0.1344 None 0.324 N 0.56 0.074 0.154104182512 gnomAD-3.1.2 2.63E-05 None None None None I None 9.65E-05 0 0 0 0 None 0 0 0 0 0
H/Q 23848 Fn3-61 23 rs1026649081 0.1344 None 0.324 N 0.56 0.074 0.154104182512 gnomAD-4.0.0 4.33879E-06 None None None None I None 8.01025E-05 1.66722E-05 None 0 0 None 0 0 0 0 0
H/R 23848 Fn3-61 23 rs775670102 0.1177 -0.024 0.324 N 0.483 0.269 0.198526703765 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 1.66058E-04
H/R 23848 Fn3-61 23 rs775670102 0.1177 -0.024 0.324 N 0.483 0.269 0.198526703765 gnomAD-4.0.0 3.18386E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43324E-05 3.02535E-05
A/D 23946 Fn3-62 23 rs1709305155 0.16 None 0.684 N 0.498 0.284 0.351830644314 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/D 23946 Fn3-62 23 rs1709305155 0.16 None 0.684 N 0.498 0.284 0.351830644314 gnomAD-4.0.0 1.2397E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69546E-06 0 0
A/G 23946 Fn3-62 23 rs1709305155 0.1155 None 0.472 N 0.435 0.238 0.239305524855 gnomAD-4.0.0 1.36871E-06 None None None None N None 0 0 None 0 5.05357E-05 None 0 0 0 0 0
A/T 23946 Fn3-62 23 rs372001011 0.0661 -0.841 0.004 N 0.149 0.106 None gnomAD-4.0.0 6.8436E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99583E-07 0 0
A/V 23946 Fn3-62 23 None 0.1103 None 0.309 N 0.429 0.216 0.251116650651 gnomAD-4.0.0 6.84357E-07 None None None None N None 0 0 None 0 0 None 1.87329E-05 0 0 0 0
F/L 24145 Fn3-63 24 rs758746801 0.1318 -0.909 None N 0.095 0.076 0.187945064343 gnomAD-2.1.1 9.17E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.9E-05 0
G/R 24244 Fn3-64 23 rs1708937897 0.2901 None 0.317 N 0.572 0.18 0.430126000877 gnomAD-4.0.0 7.2976E-07 None None None None N None 0 0 None 0 0 None 0 0 9.35069E-07 0 0
D/E 24541 Fn3-66 23 None 0.059 None None N 0.237 0.046 0.0716867268079 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/H 24541 Fn3-66 23 None 0.2655 None 0.953 N 0.724 0.289 0.359963025489 gnomAD-4.0.0 6.84369E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99594E-07 0 0
D/N 24541 Fn3-66 23 rs868185177 0.085 None 0.2 N 0.54 0.174 0.216624796971 gnomAD-4.0.0 1.36874E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99594E-07 0 1.65706E-05
E/K 24638 Fn3-67 23 rs867655242 0.433 None 0.844 N 0.515 0.272 0.257786959452 gnomAD-4.0.0 1.3687E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99573E-07 0 1.65695E-05
G/S 24831 Fn3-68 24 rs1708234650 0.0935 None None N 0.213 0.057 0.0482279557977 gnomAD-4.0.0 7.96128E-06 None None None None N None 0 0 None 0 0 None 0 0 0 7.16476E-05 0
K/R 25028 Fn3-70 23 rs1708004980 0.0833 None 0.491 N 0.452 0.147 0.228597637076 gnomAD-4.0.0 4.10883E-06 None None None None N None 0 0 None 0 0 None 0 0 5.40173E-06 0 0
E/G 25326 Fn3-72 23 rs767430531 0.1069 -0.857 0.014 N 0.333 0.191 0.275215494804 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
E/G 25326 Fn3-72 23 rs767430531 0.1069 -0.857 0.014 N 0.333 0.191 0.275215494804 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
E/G 25326 Fn3-72 23 rs767430531 0.1069 -0.857 0.014 N 0.333 0.191 0.275215494804 gnomAD-4.0.0 1.17765E-05 None None None None N None 1.33554E-05 0 None 0 0 None 0 0 1.44114E-05 0 1.60154E-05
S/G 25427 Fn3-73 23 rs1412222189 0.049 None None N 0.173 0.11 0.173771789658 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/G 25427 Fn3-73 23 rs1412222189 0.049 None None N 0.173 0.11 0.173771789658 gnomAD-4.0.0 6.57635E-06 None None None None N None 2.41359E-05 0 None 0 0 None 0 0 0 0 0
S/N 25427 Fn3-73 23 rs1171926149 0.1005 None 0.117 N 0.402 0.097 0.176091768786 gnomAD-3.1.2 1.32E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 4.78469E-04
S/N 25427 Fn3-73 23 rs1171926149 0.1005 None 0.117 N 0.402 0.097 0.176091768786 gnomAD-4.0.0 1.31551E-05 None None None None N None 2.41418E-05 0 None 0 0 None 0 0 0 0 4.78469E-04
E/G 25623 Fn3-74 23 None 0.3379 None 0.698 N 0.636 0.41 0.436671004673 gnomAD-4.0.0 1.61171E-06 None None None None I None 0 0 None 0 0 None 0 0 2.89382E-06 0 0
T/A 25720 Fn3-75 23 rs748079783 0.0692 -0.714 None N 0.176 0.12 0.162503812791 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.89E-06 0
T/A 25720 Fn3-75 23 rs748079783 0.0692 -0.714 None N 0.176 0.12 0.162503812791 gnomAD-4.0.0 2.05306E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79923E-06 1.15969E-05 0
N/I 25913 Fn3-76 24 None 0.1053 None 0.093 N 0.564 0.259 0.496495002422 gnomAD-4.0.0 1.59264E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85997E-06 0 0
N/K 25913 Fn3-76 24 None 0.1436 None None N 0.119 0.11 0.0138822411134 gnomAD-4.0.0 1.20033E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
T/P 26110 Fn3-78 23 None 0.2695 None 0.997 N 0.748 0.477 0.519783508757 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
S/C 26309 Fn3-79 24 rs1213795169 0.0727 None 0.873 N 0.467 0.314 0.464528537357 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
S/C 26309 Fn3-79 24 rs1213795169 0.0727 None 0.873 N 0.467 0.314 0.464528537357 gnomAD-4.0.0 6.57436E-06 None None None None N None 0 6.55394E-05 None 0 0 None 0 0 0 0 0
S/T 26309 Fn3-79 24 rs113597171 0.0793 None 0.285 N 0.31 0.065 0.130388298395 gnomAD-4.0.0 2.74063E-06 None None None None N None 8.99982E-05 0 None 0 0 None 0 0 0 0 1.6597E-05
G/D 26509 Fn3-81 23 rs1705957839 0.4556 None 0.062 N 0.474 0.207 0.158396225186 gnomAD-4.0.0 1.59437E-06 None None None None I None 5.66059E-05 0 None 0 0 None 0 0 0 0 0
G/S 26509 Fn3-81 23 rs1311507525 0.0759 -1.028 None N 0.249 0.055 0.0666544352282 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
G/S 26509 Fn3-81 23 rs1311507525 0.0759 -1.028 None N 0.249 0.055 0.0666544352282 gnomAD-4.0.0 1.16413E-05 None None None None I None 0 0 None 0 0 None 0 0 1.52921E-05 0 0
E/D 26705 Fn3-82 23 rs558830502 0.0819 -0.954 0.002 N 0.315 0.099 0.0666544352282 gnomAD-2.1.1 4.29102E-04 None None None None N None 0 0 None 0 6.00123E-03 None 3.27E-05 None 0 7.83E-06 1.40766E-04
E/D 26705 Fn3-82 23 rs558830502 0.0819 -0.954 0.002 N 0.315 0.099 0.0666544352282 gnomAD-3.1.2 1.77529E-04 None None None None N None 0 0 0 0 4.83559E-03 None 0 0 1.47E-05 2.06954E-04 0
E/D 26705 Fn3-82 23 rs558830502 0.0819 -0.954 0.002 N 0.315 0.099 0.0666544352282 1000 genomes 5.99042E-04 None None None None N None 0 0 None None 3E-03 0 None None None 0 None
E/D 26705 Fn3-82 23 rs558830502 0.0819 -0.954 0.002 N 0.315 0.099 0.0666544352282 gnomAD-4.0.0 1.3263E-04 None None None None N None 0 0 None 0 4.21517E-03 None 0 0 2.54322E-06 3.29439E-05 3.04185E-04
E/K 26705 Fn3-82 23 rs758610676 0.376 -0.435 0.002 N 0.379 0.232 0.18995819373 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
E/K 26705 Fn3-82 23 rs758610676 0.376 -0.435 0.002 N 0.379 0.232 0.18995819373 gnomAD-4.0.0 2.7373E-06 None None None None N None 0 2.23674E-05 None 0 2.51991E-05 None 0 0 1.7992E-06 0 0
E/A 26802 Fn3-83 23 rs201632545 0.3135 -0.726 0.678 N 0.607 0.273 0.326074293725 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
E/A 26802 Fn3-83 23 rs201632545 0.3135 -0.726 0.678 N 0.607 0.273 0.326074293725 gnomAD-4.0.0 6.84285E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99572E-07 0 0
E/G 26802 Fn3-83 23 rs201632545 0.259 -1.205 0.778 N 0.646 0.296 None gnomAD-2.1.1 2.93268E-04 None None None None N None 0 0 None 0 0 None 0 None 2.63915E-03 1.01937E-04 4.21467E-04
E/G 26802 Fn3-83 23 rs201632545 0.259 -1.205 0.778 N 0.646 0.296 None gnomAD-3.1.2 1.57845E-04 None None None None N None 0 0 0 0 0 None 1.97777E-03 0 4.41E-05 0 0
E/G 26802 Fn3-83 23 rs201632545 0.259 -1.205 0.778 N 0.646 0.296 None gnomAD-4.0.0 1.07845E-04 None None None None N None 0 0 None 0 0 None 2.4055E-03 0 1.10204E-05 0 1.12126E-04
E/K 26802 Fn3-83 23 None 0.3465 None 0.796 N 0.503 0.276 0.240491677333 gnomAD-4.0.0 1.36857E-06 None None None None N None 0 0 None 0 0 None 1.87259E-05 0 8.9957E-07 0 0
E/K 26995 Fn3-84 24 rs397517719 0.1684 -0.368 0.007 N 0.242 0.178 None gnomAD-2.1.1 2.25553E-04 None None None None N None 0 0 None 0 0 None 1.50721E-03 None 0 1.33285E-04 0
E/K 26995 Fn3-84 24 rs397517719 0.1684 -0.368 0.007 N 0.242 0.178 None gnomAD-3.1.2 1.31513E-04 None None None None N None 2.41E-05 6.56E-05 0 0 0 None 0 0 2.05858E-04 8.285E-04 0
E/K 26995 Fn3-84 24 rs397517719 0.1684 -0.368 0.007 N 0.242 0.178 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
E/K 26995 Fn3-84 24 rs397517719 0.1684 -0.368 0.007 N 0.242 0.178 None gnomAD-4.0.0 1.98983E-04 None None None None N None 1.33394E-05 1.66828E-05 None 0 0 None 3.12607E-05 0 1.44974E-04 1.51688E-03 1.28082E-04
H/Q 27094 Fn3-85 23 rs556790419 0.2793 0.263 0.013 N 0.19 0.079 0.0846915920261 gnomAD-2.1.1 1.21311E-04 None None None None N None 0 0 None 0 0 None 9.50508E-04 None 0 0 1.67336E-04
H/Q 27094 Fn3-85 23 rs556790419 0.2793 0.263 0.013 N 0.19 0.079 0.0846915920261 gnomAD-3.1.2 3.29E-05 None None None None N None 0 0 0 0 0 None 0 0 0 1.03777E-03 0
H/Q 27094 Fn3-85 23 rs556790419 0.2793 0.263 0.013 N 0.19 0.079 0.0846915920261 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
H/Q 27094 Fn3-85 23 rs556790419 0.2793 0.263 0.013 N 0.19 0.079 0.0846915920261 gnomAD-4.0.0 4.79119E-06 None None None None N None 0 0 None 0 0 None 0 0 0 8.12329E-05 0
H/Y 27094 Fn3-85 23 rs1363036038 0.1534 1.228 0.662 N 0.435 0.141 0.287603790349 gnomAD-2.1.1 6.37E-05 None None None None N None 2.29516E-04 0 None 0 0 None 0 None 0 0 0
H/Y 27094 Fn3-85 23 rs1363036038 0.1534 1.228 0.662 N 0.435 0.141 0.287603790349 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
H/Y 27094 Fn3-85 23 rs1363036038 0.1534 1.228 0.662 N 0.435 0.141 0.287603790349 gnomAD-4.0.0 1.97236E-05 None None None None N None 7.24043E-05 0 None 0 0 None 0 0 0 0 0
K/N 27192 Fn3-86 23 rs1188322990 0.2578 None 0.007 N 0.205 0.107 0.107399877778 gnomAD-4.0.0 1.59238E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85925E-06 0 0
N/I 27392 Fn3-87 24 None 0.1193 None 0.627 N 0.641 0.157 0.430808444494 gnomAD-4.0.0 1.5914E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85863E-06 0 0
N/K 27392 Fn3-87 24 rs1421975284 0.1175 -0.023 0.193 N 0.384 0.131 0.132336055621 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 6.43501E-04 None 0 None 0 0 0
N/K 27392 Fn3-87 24 rs1421975284 0.1175 -0.023 0.193 N 0.384 0.131 0.132336055621 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.93424E-04 None 0 0 0 0 0
N/K 27392 Fn3-87 24 rs1421975284 0.1175 -0.023 0.193 N 0.384 0.131 0.132336055621 gnomAD-4.0.0 6.57505E-06 None None None None N None 0 0 None 0 1.93424E-04 None 0 0 0 0 0
A/S 27491 Fn3-88 23 rs370087858 0.0709 -1.568 0.012 N 0.295 0.045 None gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.66E-05 0
A/S 27491 Fn3-88 23 rs370087858 0.0709 -1.568 0.012 N 0.295 0.045 None gnomAD-4.0.0 2.87363E-05 None None None None N None 2.98757E-05 0 None 0 0 None 0 0 3.68784E-05 0 0
A/V 27491 Fn3-88 23 None 0.11 None 0.012 N 0.334 0.066 0.330589388543 gnomAD-4.0.0 4.77354E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57481E-06 0 0
S/N 27592 Fn3-89 23 None 0.0722 None None N 0.121 0.076 0.0716867268079 gnomAD-4.0.0 1.5916E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85868E-06 0 0
E/K 27885 Fn3-91 23 None 0.4188 None 0.195 N 0.513 0.211 0.223847106136 gnomAD-4.0.0 1.59231E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85941E-06 0 0
Q/P 28176 Fn3-93 23 None 0.1293 None 0.856 N 0.562 0.281 0.344251166708 gnomAD-4.0.0 1.59298E-06 None None None None I None 0 0 None 0 2.78226E-05 None 0 0 0 0 0
S/C 28274 Fn3-94 23 rs1393654285 0.1101 -0.223 0.602 N 0.451 0.219 0.274366138417 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 9.95E-05 0 None 0 None 0 0 0
S/C 28274 Fn3-94 23 rs1393654285 0.1101 -0.223 0.602 N 0.451 0.219 0.274366138417 gnomAD-4.0.0 1.5912E-06 None None None None N None 0 0 None 4.7669E-05 0 None 0 0 0 0 0
G/E 28473 Fn3-95 24 rs911764199 0.1874 -1.336 0.976 N 0.721 0.305 0.335164054921 gnomAD-2.1.1 4.03E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
G/E 28473 Fn3-95 24 rs911764199 0.1874 -1.336 0.976 N 0.721 0.305 0.335164054921 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/E 28473 Fn3-95 24 rs911764199 0.1874 -1.336 0.976 N 0.721 0.305 0.335164054921 gnomAD-4.0.0 6.57315E-06 None None None None N None 2.41348E-05 0 None 0 0 None 0 0 0 0 0
G/R 28473 Fn3-95 24 rs779477617 0.2171 -0.762 0.976 N 0.789 0.408 0.49179695788 gnomAD-2.1.1 8.05E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
G/R 28473 Fn3-95 24 rs779477617 0.2171 -0.762 0.976 N 0.789 0.408 0.49179695788 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/R 28473 Fn3-95 24 rs779477617 0.2171 -0.762 0.976 N 0.789 0.408 0.49179695788 gnomAD-4.0.0 3.84431E-06 None None None None N None 1.69239E-05 3.39132E-05 None 0 0 None 0 0 0 0 0
G/V 28473 Fn3-95 24 None 0.2006 None 0.988 N 0.785 0.309 0.579105583989 gnomAD-4.0.0 1.59166E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85829E-06 0 0
V/L 28673 Fn3-97 23 rs766198189 0.1484 -0.472 0.007 N 0.18 0.06 0.265929055128 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 5.58E-05 None 0 None 0 0 0
V/L 28673 Fn3-97 23 rs766198189 0.1484 -0.472 0.007 N 0.18 0.06 0.265929055128 gnomAD-4.0.0 1.59131E-06 None None None None I None 0 0 None 0 2.775E-05 None 0 0 0 0 0
D/G 28867 Fn3-98 23 rs757623132 0.1747 -0.693 0.77 N 0.563 0.276 0.199424873507 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
D/G 28867 Fn3-98 23 rs757623132 0.1747 -0.693 0.77 N 0.563 0.276 0.199424873507 gnomAD-4.0.0 6.8422E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15947E-05 0
D/V 28867 Fn3-98 23 None 0.2397 None 0.911 N 0.741 0.317 0.520427616228 gnomAD-4.0.0 1.36844E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31895E-05 0
L/P 28964 Fn3-99 23 rs781089608 0.4524 -0.942 0.984 N 0.732 0.294 0.511220899679 gnomAD-2.1.1 8.06E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.93E-06 0
L/P 28964 Fn3-99 23 rs781089608 0.4524 -0.942 0.984 N 0.732 0.294 0.511220899679 gnomAD-4.0.0 1.59143E-06 None None None None N None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
E/K 29160 Fn3-100 24 None 0.1246 None 0.096 N 0.466 0.162 0.216624796971 gnomAD-4.0.0 6.84214E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99425E-07 0 0
E/Q 29160 Fn3-100 24 rs1559260637 0.0958 None 0.001 N 0.171 0.072 0.254761474806 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
E/Q 29160 Fn3-100 24 rs1559260637 0.0958 None 0.001 N 0.171 0.072 0.254761474806 gnomAD-4.0.0 4.10529E-06 None None None None N None 0 0 None 3.82643E-05 0 None 0 1.73491E-04 1.79885E-06 0 3.31301E-05
H/Q 29259 Fn3-101 23 None 0.2596 None 0.684 N 0.552 0.148 0.171388866994 gnomAD-4.0.0 6.84178E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
R/G 29556 Fn3-103 24 None 0.1157 None 0.026 N 0.217 0.059 0.24896430686 gnomAD-4.0.0 6.8417E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99423E-07 0 0
R/P 29556 Fn3-103 24 rs1207034709 0.5622 None 0.232 N 0.478 0.22 0.156986980423 gnomAD-4.0.0 6.84164E-07 None None None None N None 0 0 None 0 2.51978E-05 None 0 0 0 0 0
R/Q 29556 Fn3-103 24 None 0.0671 0.128 None N 0.121 0.048 0.0551355673512 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.65618E-04
R/Q 29556 Fn3-103 24 None 0.0671 0.128 None N 0.121 0.048 0.0551355673512 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/Q 29556 Fn3-103 24 None 0.0671 0.128 None N 0.121 0.048 0.0551355673512 gnomAD-4.0.0 1.05342E-05 None None None None N None 1.33483E-05 0 None 0 6.68419E-05 None 0 1.6442E-04 3.39025E-06 0 1.28086E-04
R/W 29556 Fn3-103 24 rs201657835 0.1308 -0.31 0.964 D 0.445 0.14 None gnomAD-2.1.1 2.5E-05 None None None None N None 8.27E-05 0 None 0 0 None 3.27E-05 None 0 3.13E-05 0
R/W 29556 Fn3-103 24 rs201657835 0.1308 -0.31 0.964 D 0.445 0.14 None gnomAD-3.1.2 3.94E-05 None None None None N None 1.44893E-04 0 0 0 0 None 0 0 0 0 0
R/W 29556 Fn3-103 24 rs201657835 0.1308 -0.31 0.964 D 0.445 0.14 None gnomAD-4.0.0 1.36327E-05 None None None None N None 1.60235E-04 0 None 0 0 None 0 0 7.62805E-06 1.09791E-05 0
S/G 29655 Fn3-104 23 None 0.0626 None 0.012 N 0.209 0.073 0.126345400529 gnomAD-4.0.0 1.20033E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
S/N 29655 Fn3-104 23 rs1387331840 0.0619 -0.434 None N 0.153 0.189 0.0297737177859 gnomAD-2.1.1 8.09E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 8.99E-06 0
S/N 29655 Fn3-104 23 rs1387331840 0.0619 -0.434 None N 0.153 0.189 0.0297737177859 gnomAD-4.0.0 4.77617E-06 None None None None I None 0 2.2898E-05 None 0 0 None 0 0 5.71788E-06 0 0
S/G 29756 Fn3-105 23 None 0.0775 None 0.425 N 0.245 0.104 0.139678290688 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/R 29756 Fn3-105 23 None 0.6776 None 0.642 N 0.447 0.157 0.260249123532 gnomAD-4.0.0 1.59237E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86007E-06 0 0
D/N 29955 Fn3-106 23 rs1700018329 0.117 None 0.117 N 0.44 0.205 0.184867976434 gnomAD-4.0.0 1.37014E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79903E-06 0 0
T/N 30052 Fn3-107 23 None 0.0913 None None N 0.275 0.121 0.193865811164 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
D/E 30247 Fn3-108 24 rs1351789713 0.1206 None 0.026 N 0.163 0.054 0.0884992946249 gnomAD-4.0.0 1.59126E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43316E-05 0
D/G 30247 Fn3-108 24 rs540756997 0.1844 -1.025 0.026 N 0.348 0.185 0.184867976434 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
D/G 30247 Fn3-108 24 rs540756997 0.1844 -1.025 0.026 N 0.348 0.185 0.184867976434 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
D/G 30247 Fn3-108 24 rs540756997 0.1844 -1.025 0.026 N 0.348 0.185 0.184867976434 1000 genomes 1.99681E-04 None None None None N None 0 1.4E-03 None None 0 0 None None None 0 None
D/G 30247 Fn3-108 24 rs540756997 0.1844 -1.025 0.026 N 0.348 0.185 0.184867976434 gnomAD-4.0.0 2.56167E-06 None None None None N None 0 3.38914E-05 None 0 0 None 0 0 0 0 0
D/E 30346 Fn3-109 23 rs917850028 0.1362 -0.486 0.767 N 0.202 0.132 0.208816687407 gnomAD-2.1.1 3.18E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
D/E 30346 Fn3-109 23 rs917850028 0.1362 -0.486 0.767 N 0.202 0.132 0.208816687407 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
D/E 30346 Fn3-109 23 rs917850028 0.1362 -0.486 0.767 N 0.202 0.132 0.208816687407 gnomAD-4.0.0 3.09829E-06 None None None None I None 0 0 None 0 0 None 0 0 4.23788E-06 0 0
D/Y 30346 Fn3-109 23 rs572533691 0.3282 0.21 1.0 N 0.843 0.416 0.599259136914 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
D/Y 30346 Fn3-109 23 rs572533691 0.3282 0.21 1.0 N 0.843 0.416 0.599259136914 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
D/Y 30346 Fn3-109 23 rs572533691 0.3282 0.21 1.0 N 0.843 0.416 0.599259136914 gnomAD-4.0.0 6.5672E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.07211E-04 0
N/K 30444 Fn3-110 23 None 0.2818 None 0.801 N 0.396 0.107 0.0806252709748 gnomAD-4.0.0 6.84333E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99572E-07 0 0
N/S 30444 Fn3-110 23 None 0.1042 None 0.454 N 0.395 0.174 0.110078149338 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/V 30741 Fn3-112 23 rs202090888 0.0971 -0.166 0.062 N 0.369 0.146 None gnomAD-2.1.1 3.58E-05 None None None None N None 0 5.66E-05 None 0 0 None 0 None 0 6.27E-05 0
A/V 30741 Fn3-112 23 rs202090888 0.0971 -0.166 0.062 N 0.369 0.146 None gnomAD-3.1.2 3.94E-05 None None None None N None 0 0 0 0 0 None 0 0 8.82E-05 0 0
A/V 30741 Fn3-112 23 rs202090888 0.0971 -0.166 0.062 N 0.369 0.146 None gnomAD-4.0.0 5.08192E-05 None None None None N None 0 5.00133E-05 None 0 0 None 0 1.64474E-04 6.18778E-05 0 8.00615E-05
D/N 31038 Fn3-114 23 None 0.2698 None 1.0 N 0.666 0.368 0.340273420219 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
L/P 31135 Fn3-115 23 rs1284369744 0.6046 -1.08 1.0 N 0.823 0.498 0.68219128047 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.49E-05 0
L/P 31135 Fn3-115 23 rs1284369744 0.6046 -1.08 1.0 N 0.823 0.498 0.68219128047 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/P 31135 Fn3-115 23 rs1284369744 0.6046 -1.08 1.0 N 0.823 0.498 0.68219128047 gnomAD-4.0.0 2.56197E-06 None None None None I None 0 0 None 0 0 None 0 0 4.78577E-06 0 0
G/E 31331 Fn3-116 24 None 0.0813 None None N 0.251 0.066 0.0884992946249 gnomAD-4.0.0 2.73676E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59785E-06 0 0
G/R 31331 Fn3-116 24 rs377660595 0.1103 -0.476 0.007 N 0.367 0.057 0.12205267543 gnomAD-2.1.1 1.8091E-04 None None None None N None 0 0 None 0 0 None 1.43791E-03 None 0 8.89E-06 0
G/R 31331 Fn3-116 24 rs377660595 0.1103 -0.476 0.007 N 0.367 0.057 0.12205267543 gnomAD-3.1.2 3.94E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 8.2713E-04 0
G/R 31331 Fn3-116 24 rs377660595 0.1103 -0.476 0.007 N 0.367 0.057 0.12205267543 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
G/R 31331 Fn3-116 24 rs377660595 0.1103 -0.476 0.007 N 0.367 0.057 0.12205267543 gnomAD-4.0.0 9.41826E-05 None None None None N None 0 0 None 0 2.22916E-05 None 0 0 4.23793E-05 1.08684E-03 3.20102E-05
E/G 31430 Fn3-117 23 rs1697596654 0.2864 None 0.978 N 0.656 0.432 0.470566500458 gnomAD-4.0.0 1.5913E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8585E-06 0 0
E/K 31430 Fn3-117 23 rs868051341 0.3673 None 0.978 N 0.554 0.403 0.303453137403 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 31430 Fn3-117 23 rs868051341 0.3673 None 0.978 N 0.554 0.403 0.303453137403 gnomAD-4.0.0 3.04484E-06 None None None None I None 0 0 None 0 0 None 0 0 3.61477E-06 0 0
S/C 31730 Fn3-119 23 rs1213250473 0.0932 None 0.851 N 0.429 0.282 0.40032279838 gnomAD-4.0.0 6.15831E-06 None None None None N None 0 0 None 0 0 None 0 0 8.09556E-06 0 0
S/G 31730 Fn3-119 23 rs1213250473 0.0743 -0.861 0.042 N 0.241 0.13 0.144782658237 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
S/G 31730 Fn3-119 23 rs1213250473 0.0743 -0.861 0.042 N 0.241 0.13 0.144782658237 gnomAD-4.0.0 6.84257E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99507E-07 0 0
S/N 31730 Fn3-119 23 rs2555816 0.0629 None None N 0.103 0.073 0.0551355673512 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/R 31829 Fn3-120 23 rs762048345 0.1035 -0.502 0.017 N 0.457 0.084 0.17258766438 gnomAD-2.1.1 8.03E-06 None None None None N None 0 5.79E-05 None 0 0 None 0 None 0 0 0
T/R 31829 Fn3-120 23 rs762048345 0.1035 -0.502 0.017 N 0.457 0.084 0.17258766438 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
T/R 31829 Fn3-120 23 rs762048345 0.1035 -0.502 0.017 N 0.457 0.084 0.17258766438 gnomAD-4.0.0 6.40628E-06 None None None None N None 0 8.474E-05 None 0 0 None 0 0 0 0 0
T/N 31931 Fn3-121 23 None 0.1123 None 0.982 N 0.619 0.304 0.425148423609 gnomAD-4.0.0 2.73702E-06 None None None None I None 0 0 None 0 0 None 0 0 2.69863E-06 0 1.65651E-05
E/A 32127 Fn3-122 23 None 0.1744 None 0.896 N 0.637 0.362 0.305086939656 gnomAD-4.0.0 2.7501E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69889E-06 0 1.6581E-05
E/Q 32127 Fn3-122 23 None 0.1866 None 0.946 N 0.585 0.187 0.242244723065 gnomAD-4.0.0 1.60953E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86E-06 0 0
E/V 32127 Fn3-122 23 None 0.3111 None 0.984 N 0.703 0.453 0.470484629704 gnomAD-4.0.0 6.87524E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99628E-07 0 0
E/K 32422 Fn3-124 24 rs1695041603 0.124 None 0.124 N 0.605 0.183 0.224531998449 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/K 32422 Fn3-124 24 rs1695041603 0.124 None 0.124 N 0.605 0.183 0.224531998449 gnomAD-4.0.0 6.57488E-06 None None None None N None 2.41464E-05 0 None 0 0 None 0 0 0 0 0
S/N 32622 Fn3-126 23 rs777613491 0.1166 -1.143 0.999 N 0.57 0.328 0.281381271821 gnomAD-2.1.1 8.04E-06 None None None None N None 6.46E-05 0 None 0 0 None 3.27E-05 None 0 0 0
S/N 32622 Fn3-126 23 rs777613491 0.1166 -1.143 0.999 N 0.57 0.328 0.281381271821 gnomAD-4.0.0 3.4211E-06 None None None None N None 2.98864E-05 0 None 0 0 None 0 0 1.79901E-06 1.15931E-05 1.65656E-05
S/R 32622 Fn3-126 23 rs1693783510 0.6225 None 0.999 N 0.689 0.376 0.223146558224 gnomAD-4.0.0 1.59133E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02425E-05
R/K 32818 Fn3-127 24 rs794729551 0.0929 -0.187 0.011 N 0.21 0.121 0.151104730317 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
R/K 32818 Fn3-127 24 rs794729551 0.0929 -0.187 0.011 N 0.21 0.121 0.151104730317 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
R/K 32818 Fn3-127 24 rs794729551 0.0929 -0.187 0.011 N 0.21 0.121 0.151104730317 gnomAD-4.0.0 5.12407E-06 None None None None N None 0 0 None 0 0 None 0 0 9.57171E-06 0 0
S/C 32919 Fn3-128 24 None 0.1582 None 1.0 N 0.601 0.394 0.411665641125 gnomAD-4.0.0 1.59129E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85838E-06 0 0
S/F 32919 Fn3-128 24 None 0.3659 None 0.999 N 0.69 0.405 0.583773441324 gnomAD-4.0.0 1.59129E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85838E-06 0 0
E/G 33020 Fn3-129 23 rs907499799 0.1537 None 0.993 N 0.657 0.331 0.376570364461 gnomAD-4.0.0 4.10551E-06 None None None None N None 1.49441E-04 0 None 0 0 None 0 0 0 0 1.65645E-05
E/K 33020 Fn3-129 23 rs751222141 0.1996 -0.158 0.993 N 0.587 0.341 0.27855597813 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
E/K 33020 Fn3-129 23 rs751222141 0.1996 -0.158 0.993 N 0.587 0.341 0.27855597813 gnomAD-3.1.2 1.97E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 2.94E-05 0 0
E/K 33020 Fn3-129 23 rs751222141 0.1996 -0.158 0.993 N 0.587 0.341 0.27855597813 gnomAD-4.0.0 2.60288E-05 None None None None N None 1.33515E-05 0 None 0 0 None 1.5627E-05 0 3.30586E-05 0 1.60108E-05
E/Q 33020 Fn3-129 23 None 0.1478 None 0.993 N 0.609 0.278 0.259761712551 gnomAD-4.0.0 6.84262E-07 None None None None N None 0 0 None 0 0 None 0 0 8.9953E-07 0 0
K/N 33313 Fn3-130 24 rs1691982544 0.4477 None 0.83 N 0.694 0.162 0.151104730317 gnomAD-3.1.2 1.31E-05 None None None None N None 0 1.31113E-04 0 0 0 None 0 0 0 0 0
K/N 33313 Fn3-130 24 rs1691982544 0.4477 None 0.83 N 0.694 0.162 0.151104730317 gnomAD-4.0.0 1.31454E-05 None None None None N None 0 1.31113E-04 None 0 0 None 0 0 0 0 0
T/I 33711 Fn3-132 23 rs1248094195 0.1359 0.06 0.001 N 0.188 0.142 0.202086224978 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.88E-06 0
T/S 33711 Fn3-132 23 None 0.104 None 0.003 N 0.213 0.073 0.134241683229 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.