Structural position:

  • Domain Type: Fn3
  • Aligned Position: 36
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand C

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
I/L 15690 Fn3-1 34 None 0.0987 None 0.002 N 0.051 0.071 0.411133732114 gnomAD-4.0.0 6.84722E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15972E-05 0
I/M 15690 Fn3-1 34 rs1399689836 0.0993 -0.357 0.934 N 0.392 0.115 0.509346181843 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
I/M 15690 Fn3-1 34 rs1399689836 0.0993 -0.357 0.934 N 0.392 0.115 0.509346181843 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/M 15690 Fn3-1 34 rs1399689836 0.0993 -0.357 0.934 N 0.392 0.115 0.509346181843 gnomAD-4.0.0 6.58241E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47284E-05 0 0
I/V 15690 Fn3-1 34 None 0.0869 None 0.267 N 0.204 0.04 0.363356657567 gnomAD-4.0.0 1.36945E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79985E-06 0 0
T/I 15791 Fn3-2 34 rs540588062 0.2329 0.007 1.0 N 0.799 0.42 0.61225159808 gnomAD-2.1.1 3.22E-05 None None None None I None 0 0 None 0 0 None 2.28773E-04 None 0 0 1.65837E-04
T/I 15791 Fn3-2 34 rs540588062 0.2329 0.007 1.0 N 0.799 0.42 0.61225159808 gnomAD-3.1.2 6.59E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07125E-04 0
T/I 15791 Fn3-2 34 rs540588062 0.2329 0.007 1.0 N 0.799 0.42 0.61225159808 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 0 0 None None None 1E-03 None
T/I 15791 Fn3-2 34 rs540588062 0.2329 0.007 1.0 N 0.799 0.42 0.61225159808 gnomAD-4.0.0 7.44133E-06 None None None None I None 0 0 None 0 0 None 0 0 8.48104E-07 9.88446E-05 3.20431E-05
T/P 15791 Fn3-2 34 rs1269031927 0.6075 -0.337 1.0 D 0.786 0.574 0.665027746237 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
T/P 15791 Fn3-2 34 rs1269031927 0.6075 -0.337 1.0 D 0.786 0.574 0.665027746237 gnomAD-4.0.0 1.59348E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86257E-06 0 0
K/N 16188 Fn3-5 34 None 0.6843 None 0.782 N 0.57 0.161 0.166414681773 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/P 16384 Fn3-6 34 rs1559808274 0.8926 -0.322 1.0 D 0.821 0.556 0.523082183605 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.95E-06 0
T/P 16384 Fn3-6 34 rs1559808274 0.8926 -0.322 1.0 D 0.821 0.556 0.523082183605 gnomAD-4.0.0 1.59351E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86146E-06 0 0
T/K 16483 Fn3-7 34 rs1421106581 0.4995 None 0.978 N 0.7 0.401 0.406257615169 gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
T/K 16483 Fn3-7 34 rs1421106581 0.4995 None 0.978 N 0.7 0.401 0.406257615169 gnomAD-4.0.0 6.58371E-06 None None None None I None 2.41628E-05 0 None 0 0 None 0 0 0 0 0
T/I 16684 Fn3-9 34 rs1303563982 0.5223 -0.092 1.0 N 0.825 0.481 0.490489133298 gnomAD-2.1.1 4.08E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.09E-06 0
T/I 16684 Fn3-9 34 rs1303563982 0.5223 -0.092 1.0 N 0.825 0.481 0.490489133298 gnomAD-4.0.0 1.36963E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79975E-06 0 0
T/N 16684 Fn3-9 34 None 0.4589 None 1.0 D 0.769 0.499 0.499535901811 gnomAD-4.0.0 1.36963E-06 None None None None I None 0 4.48109E-05 None 0 0 None 0 0 0 0 0
T/S 16684 Fn3-9 34 None 0.3266 None 0.999 D 0.566 0.475 0.27132560031 gnomAD-4.0.0 6.84816E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99873E-07 0 0
Q/H 16784 Fn3-10 34 None 0.2802 None 0.989 N 0.377 0.201 0.33085137897 gnomAD-4.0.0 1.20034E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
Q/R 16784 Fn3-10 34 rs765976576 0.166 0.164 0.891 N 0.267 0.146 0.183819452728 gnomAD-2.1.1 4.12E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.6909E-04
Q/R 16784 Fn3-10 34 rs765976576 0.166 0.164 0.891 N 0.267 0.146 0.183819452728 gnomAD-4.0.0 1.60291E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.04044E-05
I/T 16885 Fn3-11 34 rs2056332746 0.1085 None 0.27 N 0.313 0.227 0.469248961376 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
I/V 16885 Fn3-11 34 rs1405647586 0.0888 -0.494 0.139 N 0.16 0.045 0.382761230579 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
I/V 16885 Fn3-11 34 rs1405647586 0.0888 -0.494 0.139 N 0.16 0.045 0.382761230579 gnomAD-4.0.0 5.47609E-06 None None None None I None 0 0 None 0 0 None 0 0 7.19819E-06 0 0
L/S 17502 Fn3-15 33 rs368013299 0.1746 -0.495 0.81 N 0.404 0.312 None gnomAD-2.1.1 1.09E-05 None None None None I None 8.35E-05 0 None 0 0 None 0 None 0 7.93E-06 0
L/S 17502 Fn3-15 33 rs368013299 0.1746 -0.495 0.81 N 0.404 0.312 None gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
L/S 17502 Fn3-15 33 rs368013299 0.1746 -0.495 0.81 N 0.404 0.312 None gnomAD-4.0.0 4.9642E-06 None None None None I None 6.68021E-05 0 None 0 0 None 0 0 2.54491E-06 0 0
L/W 17502 Fn3-15 33 rs368013299 0.3516 None 0.99 N 0.615 0.539 0.826545055579 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
L/W 17502 Fn3-15 33 rs368013299 0.3516 None 0.99 N 0.615 0.539 0.826545055579 gnomAD-4.0.0 6.57825E-06 None None None None I None 2.41324E-05 0 None 0 0 None 0 0 0 0 0
V/I 17602 Fn3-16 34 None 0.0608 None None N 0.059 0.185 0.132336055621 gnomAD-4.0.0 6.84508E-07 None None None None I None 0 0 None 0 0 None 0 1.73671E-04 0 0 0
V/L 17602 Fn3-16 34 rs771120988 0.0934 -0.153 None N 0.069 0.174 0.159798565429 gnomAD-2.1.1 8.06E-06 None None None None I None 0 5.8E-05 None 0 0 None 0 None 0 0 0
V/L 17602 Fn3-16 34 rs771120988 0.0934 -0.153 None N 0.069 0.174 0.159798565429 gnomAD-4.0.0 1.36902E-06 None None None None I None 0 4.47507E-05 None 0 0 None 0 0 0 0 0
T/I 17797 Fn3-17 34 rs727503610 0.257 -0.036 0.059 N 0.292 0.154 0.294561560033 gnomAD-2.1.1 1.07E-05 None None None None I None 0 0 None 0 0 None 0 None 0 2.35E-05 0
T/I 17797 Fn3-17 34 rs727503610 0.257 -0.036 0.059 N 0.292 0.154 0.294561560033 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 0 2.94E-05 0 0
T/I 17797 Fn3-17 34 rs727503610 0.257 -0.036 0.059 N 0.292 0.154 0.294561560033 gnomAD-4.0.0 4.34004E-06 None None None None I None 0 0 None 0 0 None 0 0 5.08763E-06 0 1.6022E-05
Q/E 17895 Fn3-18 34 rs796463261 0.0925 None 0.025 N 0.202 0.085 0.15556083564 gnomAD-3.1.2 6.61E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/E 17895 Fn3-18 34 rs796463261 0.0925 None 0.025 N 0.202 0.085 0.15556083564 gnomAD-4.0.0 1.32022E-05 None None None None I None 0 0 None 0 0 None 0 0 2.94863E-05 0 0
T/A 18098 Fn3-19 34 None 0.2322 None 0.999 N 0.523 0.564 0.383256108077 gnomAD-4.0.0 1.36946E-06 None None None None I None 0 0 None 0 0 None 0 0 1.8E-06 0 0
K/E 18512 Fn3-22 34 None 0.4241 None 0.939 N 0.522 0.255 0.296679040009 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
T/I 18612 Fn3-23 34 None 0.2712 None 0.999 N 0.754 0.429 0.520803792171 gnomAD-4.0.0 1.37032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80063E-06 0 0
T/N 18612 Fn3-23 34 rs765352575 0.2181 -1.006 0.997 N 0.623 0.381 0.47290127212 gnomAD-2.1.1 4.06E-06 None None None None N None 0 0 None 0 0 None 3.3E-05 None 0 0 0
T/N 18612 Fn3-23 34 rs765352575 0.2181 -1.006 0.997 N 0.623 0.381 0.47290127212 gnomAD-4.0.0 1.37032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.16347E-05 1.65893E-05
T/K 18818 Fn3-24 35 rs945270235 0.5852 -0.395 1.0 N 0.823 0.447 0.520110530135 gnomAD-2.1.1 4.1E-06 None None None None I None 0 2.97E-05 None 0 0 None 0 None 0 0 0
T/K 18818 Fn3-24 35 rs945270235 0.5852 -0.395 1.0 N 0.823 0.447 0.520110530135 gnomAD-4.0.0 1.60193E-06 None None None None I None 0 2.32515E-05 None 0 0 None 0 0 0 0 0
T/K 18917 Fn3-25 34 rs370348484 0.4174 None 1.0 N 0.86 0.409 None gnomAD-4.0.0 1.59383E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86066E-06 0 0
T/A 19217 Fn3-27 35 None 0.1928 None 0.999 N 0.565 0.456 0.298403945805 gnomAD-4.0.0 1.37294E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.3546E-05 0
T/I 19217 Fn3-27 35 None 0.4151 None 1.0 N 0.86 0.41 0.485562757867 gnomAD-4.0.0 1.60349E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8752E-06 0 0
I/L 19317 Fn3-28 34 rs752651782 0.1216 None None N 0.093 0.153 0.356072328145 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/L 19317 Fn3-28 34 rs752651782 0.1216 None None N 0.093 0.153 0.356072328145 gnomAD-4.0.0 6.57246E-06 None None None None I None 2.41138E-05 0 None 0 0 None 0 0 0 0 0
I/T 19317 Fn3-28 34 rs1249290348 0.1153 -1.191 None N 0.147 0.152 0.475112344478 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
I/T 19317 Fn3-28 34 rs1249290348 0.1153 -1.191 None N 0.147 0.152 0.475112344478 gnomAD-4.0.0 3.18466E-06 None None None None I None 0 0 None 0 2.77793E-05 None 0 0 2.86035E-06 0 0
I/V 19317 Fn3-28 34 rs752651782 0.078 -1.003 0.019 N 0.169 0.115 0.506068822696 gnomAD-2.1.1 4.02E-06 None None None None I None 0 2.9E-05 None 0 0 None 0 None 0 0 0
I/V 19317 Fn3-28 34 rs752651782 0.078 -1.003 0.019 N 0.169 0.115 0.506068822696 gnomAD-4.0.0 1.59231E-06 None None None None I None 0 2.28791E-05 None 0 0 None 0 0 0 0 0
T/K 19611 Fn3-30 33 None 0.1753 None 0.018 N 0.275 0.296 0.273503213844 gnomAD-4.0.0 1.20034E-06 None None None None I None 0 0 None 0 0 None 0 0 1.31253E-06 0 0
T/I 19910 Fn3-32 34 rs369476725 0.3256 0.042 1.0 N 0.779 0.454 None gnomAD-2.1.1 1.49853E-04 None None None None I None 0 5.83E-05 None 1.9988E-03 0 None 3.28E-05 None 0 8.96E-05 6.69568E-04
T/I 19910 Fn3-32 34 rs369476725 0.3256 0.042 1.0 N 0.779 0.454 None gnomAD-3.1.2 9.21E-05 None None None None I None 0 0 0 1.44175E-03 0 None 0 0 1.17689E-04 0 4.78469E-04
T/I 19910 Fn3-32 34 rs369476725 0.3256 0.042 1.0 N 0.779 0.454 None gnomAD-4.0.0 7.75146E-05 None None None None I None 0 3.33968E-05 None 2.02826E-03 0 None 0 4.93908E-04 3.22188E-05 1.09902E-05 3.36571E-04
T/P 20010 Fn3-33 34 None 0.5564 None 1.0 D 0.838 0.54 0.60587874566 gnomAD-4.0.0 1.59233E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02627E-05
I/V 20205 Fn3-34 35 rs1278691474 0.0949 None 0.267 N 0.212 0.11 0.421550847248 gnomAD-2.1.1 3.19E-05 None None None None I None 0 1.18203E-03 None 0 0 None 0 None 0 0 0
I/V 20205 Fn3-34 35 rs1278691474 0.0949 None 0.267 N 0.212 0.11 0.421550847248 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
I/V 20205 Fn3-34 35 rs1278691474 0.0949 None 0.267 N 0.212 0.11 0.421550847248 gnomAD-4.0.0 2.56394E-06 None None None None I None 0 1.69607E-05 None 0 0 None 0 0 0 0 2.84527E-05
T/I 20602 Fn3-37 34 rs1342930607 0.3369 None 1.0 N 0.823 0.434 0.467839254973 gnomAD-4.0.0 1.5924E-06 None None None None I None 0 0 None 0 2.78489E-05 None 0 0 0 0 0
L/Q 20701 Fn3-38 34 rs1383995916 0.2969 None 1.0 N 0.796 0.428 0.73673398233 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
L/Q 20701 Fn3-38 34 rs1383995916 0.2969 None 1.0 N 0.796 0.428 0.73673398233 gnomAD-4.0.0 6.57549E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47111E-05 0 0
T/I 20996 Fn3-40 34 rs1178872023 0.1609 -0.166 1.0 N 0.86 0.421 0.480724696071 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/I 20996 Fn3-40 34 rs1178872023 0.1609 -0.166 1.0 N 0.86 0.421 0.480724696071 gnomAD-4.0.0 1.59225E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.4334E-05 0
I/T 21097 Fn3-41 34 rs759579228 0.1517 -0.684 0.942 N 0.635 0.306 0.635244795662 gnomAD-2.1.1 8.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
I/T 21097 Fn3-41 34 rs759579228 0.1517 -0.684 0.942 N 0.635 0.306 0.635244795662 gnomAD-4.0.0 1.27456E-05 None None None None I None 0 0 None 0 2.78443E-05 None 0 0 2.00317E-05 0 0
T/A 21299 Fn3-42 34 rs774568660 0.1101 None 0.989 N 0.455 0.351 0.44711355012 gnomAD-4.0.0 1.59313E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86069E-06 0 0
T/I 21299 Fn3-42 34 rs1031526299 0.1702 0.048 0.956 N 0.616 0.377 None gnomAD-2.1.1 6.38E-05 None None None None N None 2.29674E-04 0 None 0 0 None 0 None 0 0 0
T/I 21299 Fn3-42 34 rs1031526299 0.1702 0.048 0.956 N 0.616 0.377 None gnomAD-3.1.2 1.98E-05 None None None None N None 7.25E-05 0 0 0 0 None 0 0 0 0 0
T/I 21299 Fn3-42 34 rs1031526299 0.1702 0.048 0.956 N 0.616 0.377 None gnomAD-4.0.0 5.13106E-06 None None None None N None 6.77897E-05 0 None 0 0 None 0 0 0 0 0
D/N 21399 Fn3-43 34 rs749018114 0.1396 0.076 0.581 N 0.163 0.207 None gnomAD-2.1.1 2.41E-05 None None None None I None 6.46E-05 0 None 9.95E-05 0 None 3.27E-05 None 0 2.67E-05 0
D/N 21399 Fn3-43 34 rs749018114 0.1396 0.076 0.581 N 0.163 0.207 None gnomAD-3.1.2 3.29E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 4.41E-05 0 0
D/N 21399 Fn3-43 34 rs749018114 0.1396 0.076 0.581 N 0.163 0.207 None gnomAD-4.0.0 2.66592E-05 None None None None I None 2.67208E-05 0 None 6.76315E-05 0 None 0 0 3.05248E-05 2.19674E-05 1.60185E-05
T/I 21593 Fn3-44 35 None 0.7285 None 1.0 N 0.853 0.437 0.462022758384 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 3.66327E-05
T/P 21593 Fn3-44 35 rs745369313 0.8828 -0.543 1.0 D 0.849 0.577 0.50466331119 gnomAD-2.1.1 8.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
T/P 21593 Fn3-44 35 rs745369313 0.8828 -0.543 1.0 D 0.849 0.577 0.50466331119 gnomAD-4.0.0 8.89661E-06 None None None None I None 0 0 None 0 0 None 0 0 1.16951E-05 0 0
I/V 21692 Fn3-45 34 rs758476009 0.0788 -0.591 0.001 N 0.13 0.129 0.402043589563 gnomAD-2.1.1 1.03674E-04 None None None None I None 0 0 None 0 0 None 0 None 7.99744E-04 7.04E-05 0
I/V 21692 Fn3-45 34 rs758476009 0.0788 -0.591 0.001 N 0.13 0.129 0.402043589563 gnomAD-3.1.2 5.26E-05 None None None None I None 0 0 0 0 0 None 4.7081E-04 0 4.41E-05 0 0
I/V 21692 Fn3-45 34 rs758476009 0.0788 -0.591 0.001 N 0.13 0.129 0.402043589563 gnomAD-4.0.0 1.06004E-04 None None None None I None 0 0 None 0 0 None 7.81079E-04 0 9.83439E-05 0 8.00948E-05
I/M 21790 Fn3-46 34 rs764130758 0.1504 None 0.901 N 0.546 0.28 0.462721901306 gnomAD-2.1.1 4.13E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.69722E-04
I/M 21790 Fn3-46 34 rs764130758 0.1504 None 0.901 N 0.546 0.28 0.462721901306 gnomAD-4.0.0 1.60047E-06 None None None None I None 5.6773E-05 0 None 0 0 None 0 0 0 0 0
I/T 21790 Fn3-46 34 rs727503580 0.0954 -1.644 0.034 N 0.235 0.274 0.501559347837 gnomAD-2.1.1 1.24E-05 None None None None I None 1.33351E-04 0 None 0 0 None 3.37E-05 None 0 0 0
I/T 21790 Fn3-46 34 rs727503580 0.0954 -1.644 0.034 N 0.235 0.274 0.501559347837 gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
I/T 21790 Fn3-46 34 rs727503580 0.0954 -1.644 0.034 N 0.235 0.274 0.501559347837 gnomAD-4.0.0 1.1584E-05 None None None None I None 8.46711E-05 0 None 0 4.89309E-05 None 0 0 2.40233E-06 1.3541E-05 0
T/A 21989 Fn3-47 34 rs1183678109 0.2293 -0.637 0.958 N 0.443 0.453 0.33835085245 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/A 21989 Fn3-47 34 rs1183678109 0.2293 -0.637 0.958 N 0.443 0.453 0.33835085245 gnomAD-4.0.0 1.59323E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43377E-05 0
T/A 22088 Fn3-48 34 rs1559509011 0.1341 None 0.954 N 0.487 0.28 0.336155897331 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 5.6E-05 None 0 None 0 0 0
T/A 22088 Fn3-48 34 rs1559509011 0.1341 None 0.954 N 0.487 0.28 0.336155897331 gnomAD-4.0.0 1.59308E-06 None None None None I None 0 0 None 0 2.77562E-05 None 0 0 0 0 0
T/N 22088 Fn3-48 34 rs886044538 0.195 None 0.998 N 0.533 0.364 0.417334834585 gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
T/N 22088 Fn3-48 34 rs886044538 0.195 None 0.998 N 0.533 0.364 0.417334834585 gnomAD-4.0.0 1.97314E-05 None None None None I None 7.24218E-05 0 None 0 0 None 0 0 0 0 0
T/P 22088 Fn3-48 34 rs1559509011 0.6643 None 0.998 D 0.665 0.473 0.488827753106 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 0 None 0 3.16456E-03 0 0 4.78927E-04
T/P 22088 Fn3-48 34 rs1559509011 0.6643 None 0.998 D 0.665 0.473 0.488827753106 gnomAD-4.0.0 1.31427E-05 None None None None I None 0 0 None 0 0 None 0 3.40136E-03 0 0 4.73934E-04
I/T 22189 Fn3-49 34 rs369934753 0.0737 -1.597 0.946 N 0.543 0.36 None gnomAD-2.1.1 1.44E-05 None None None None I None 4.17E-05 0 None 0 0 None 0 None 0 2.37E-05 0
I/T 22189 Fn3-49 34 rs369934753 0.0737 -1.597 0.946 N 0.543 0.36 None gnomAD-3.1.2 2.63E-05 None None None None I None 2.41E-05 0 0 0 0 None 0 0 4.41E-05 0 0
I/T 22189 Fn3-49 34 rs369934753 0.0737 -1.597 0.946 N 0.543 0.36 None gnomAD-4.0.0 3.84645E-05 None None None None I None 1.33583E-05 0 None 0 0 None 0 0 5.08921E-05 0 1.60354E-05
I/M 22387 Fn3-50 34 rs1305023299 0.1042 -0.232 0.954 N 0.267 0.198 0.412587454835 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
I/M 22387 Fn3-50 34 rs1305023299 0.1042 -0.232 0.954 N 0.267 0.198 0.412587454835 gnomAD-4.0.0 3.18441E-06 None None None None I None 0 0 None 0 0 None 0 0 5.7205E-06 0 0
I/T 22387 Fn3-50 34 rs768996343 0.0904 -0.249 0.005 N 0.106 0.203 0.338592109245 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 0 1.65948E-04
I/T 22387 Fn3-50 34 rs768996343 0.0904 -0.249 0.005 N 0.106 0.203 0.338592109245 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
I/T 22387 Fn3-50 34 rs768996343 0.0904 -0.249 0.005 N 0.106 0.203 0.338592109245 gnomAD-4.0.0 3.84552E-06 None None None None I None 0 1.69584E-05 None 0 2.42836E-05 None 0 0 2.39466E-06 0 0
I/V 22387 Fn3-50 34 None 0.0833 None 0.08 N 0.162 0.124 0.423597194605 gnomAD-4.0.0 1.59222E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86025E-06 0 0
I/L 22484 Fn3-51 34 None 0.093 None None N 0.067 0.091 0.374613414588 gnomAD-4.0.0 6.84401E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99666E-07 0 0
I/T 22484 Fn3-51 34 rs903308296 0.0505 -0.747 None N 0.101 0.076 0.117506650769 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.94E-06 0
I/T 22484 Fn3-51 34 rs903308296 0.0505 -0.747 None N 0.101 0.076 0.117506650769 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 22484 Fn3-51 34 rs903308296 0.0505 -0.747 None N 0.101 0.076 0.117506650769 gnomAD-4.0.0 2.16964E-05 None None None None I None 0 0 None 0 0 None 0 0 2.96737E-05 0 0
I/V 22484 Fn3-51 34 None 0.0841 None None N 0.067 0.112 0.353974658523 gnomAD-4.0.0 6.84401E-07 None None None None I None 0 0 None 0 0 None 1.87329E-05 0 0 0 0
T/I 22776 Fn3-53 34 rs1347609224 0.1934 None 1.0 N 0.841 0.459 0.366848117066 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 22776 Fn3-53 34 rs1347609224 0.1934 None 1.0 N 0.841 0.459 0.366848117066 gnomAD-4.0.0 6.57782E-06 None None None None I None 2.41464E-05 0 None 0 0 None 0 0 0 0 0
T/R 22776 Fn3-53 34 None 0.4522 None 1.0 N 0.842 0.47 0.463843524616 gnomAD-4.0.0 1.20373E-06 None None None None I None 0 1.01833E-03 None 0 0 None 0 0 0 0 0
T/A 23172 Fn3-56 34 None 0.0925 None 0.027 N 0.375 0.177 0.194818534648 gnomAD-4.0.0 1.59167E-06 None None None None I None 0 0 None 0 0 None 0 0 2.8593E-06 0 0
T/I 23172 Fn3-56 34 rs752643010 0.1151 -0.279 0.002 N 0.232 0.129 0.222439326576 gnomAD-2.1.1 8.05E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 8.9E-06 0
T/I 23172 Fn3-56 34 rs752643010 0.1151 -0.279 0.002 N 0.232 0.129 0.222439326576 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 23172 Fn3-56 34 rs752643010 0.1151 -0.279 0.002 N 0.232 0.129 0.222439326576 gnomAD-4.0.0 9.91731E-06 None None None None I None 1.33601E-05 0 None 0 0 None 0 0 1.27161E-05 0 0
T/K 23172 Fn3-56 34 rs752643010 0.19 -0.627 0.062 N 0.369 0.222 0.242244723065 gnomAD-2.1.1 2.41E-05 None None None None I None 0 0 None 0 0 None 1.96078E-04 None 0 0 0
T/K 23172 Fn3-56 34 rs752643010 0.19 -0.627 0.062 N 0.369 0.222 0.242244723065 gnomAD-4.0.0 2.05287E-05 None None None None I None 0 0 None 0 0 None 0 1.73551E-04 0 3.24653E-04 1.65689E-05
T/A 23273 Fn3-57 34 rs1233267673 0.0988 None 0.183 N 0.374 0.208 0.275215494804 gnomAD-4.0.0 1.70038E-06 None None None None I None 0 0 None 0 0 None 0 0 2.99441E-06 0 0
T/I 23273 Fn3-57 34 None 0.1191 None 0.001 N 0.154 0.166 0.31077124679 gnomAD-4.0.0 7.03575E-07 None None None None I None 0 0 None 0 0 None 0 0 9.12475E-07 0 0
T/S 23273 Fn3-57 34 rs371067787 0.1303 -1.117 0.183 N 0.384 0.127 0.231231049324 gnomAD-2.1.1 4.81E-06 None None None None I None 6.83E-05 0 None 0 0 None 0 None 0 0 0
T/S 23273 Fn3-57 34 rs371067787 0.1303 -1.117 0.183 N 0.384 0.127 0.231231049324 gnomAD-4.0.0 7.03575E-07 None None None None I None 0 0 None 0 0 None 0 0 9.12475E-07 0 0
T/K 23468 Fn3-58 34 None 0.2692 None 0.134 N 0.21 0.252 0.266843984389 gnomAD-4.0.0 1.59179E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85919E-06 0 0
S/I 23760 Fn3-60 35 rs765988593 0.4538 -0.108 0.007 N 0.246 0.274 0.327952845175 gnomAD-2.1.1 4.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9E-06 0
S/I 23760 Fn3-60 35 rs765988593 0.4538 -0.108 0.007 N 0.246 0.274 0.327952845175 gnomAD-4.0.0 1.59278E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85981E-06 0 0
S/R 23760 Fn3-60 35 rs2154171828 0.9602 -0.09 0.884 N 0.358 0.349 0.255777322467 gnomAD-2.1.1 1.22E-05 None None None None I None 0 0 None 0 0 None 0 None 9.3E-05 9E-06 0
S/R 23760 Fn3-60 35 rs2154171828 0.9602 -0.09 0.884 N 0.358 0.349 0.255777322467 gnomAD-4.0.0 2.73797E-06 None None None None I None 0 0 None 0 0 None 5.63126E-05 0 0 0 1.65782E-05
T/I 23957 Fn3-62 34 None 0.2366 None 1.0 N 0.803 0.566 0.464098490096 gnomAD-4.0.0 6.8468E-07 None None None None I None 2.99097E-05 0 None 0 0 None 0 0 0 0 0
T/N 23957 Fn3-62 34 None 0.2562 None 1.0 N 0.713 0.496 0.452640719197 gnomAD-4.0.0 6.8468E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00025E-07 0 0
T/S 23957 Fn3-62 34 rs1330924504 0.1914 -0.572 0.999 N 0.519 0.467 0.355865052028 gnomAD-2.1.1 4.04E-06 None None None None I None 6.47E-05 0 None 0 0 None 0 None 0 0 0
T/S 23957 Fn3-62 34 rs1330924504 0.1914 -0.572 0.999 N 0.519 0.467 0.355865052028 gnomAD-4.0.0 1.36936E-06 None None None None I None 2.99097E-05 0 None 0 0 None 0 0 0 1.15974E-05 0
D/N 24156 Fn3-63 35 rs1709040632 0.0898 None 0.22 N 0.496 0.149 0.159798565429 gnomAD-3.1.2 6.58E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
D/N 24156 Fn3-63 35 rs1709040632 0.0898 None 0.22 N 0.496 0.149 0.159798565429 gnomAD-4.0.0 6.57592E-06 None None None None I None 2.41336E-05 0 None 0 0 None 0 0 0 0 0
I/V 24255 Fn3-64 34 None 0.0678 None 0.005 N 0.158 0.128 0.400033932507 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 24356 Fn3-65 34 rs1489472949 0.0846 -0.854 0.656 N 0.48 0.348 0.289847578895 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 0 0
T/A 24356 Fn3-65 34 rs1489472949 0.0846 -0.854 0.656 N 0.48 0.348 0.289847578895 gnomAD-4.0.0 1.59247E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43295E-05 0
T/I 24356 Fn3-65 34 None 0.1027 None 0.89 N 0.503 0.351 0.389283895039 gnomAD-4.0.0 1.59248E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43295E-05 0
K/Q 24552 Fn3-66 34 None 0.2395 None 0.008 N 0.365 0.12 0.134241683229 gnomAD-4.0.0 1.59307E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43382E-05 0
L/P 24649 Fn3-67 34 rs1559410802 0.7149 None 0.995 N 0.703 0.383 0.802570031157 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66223E-04
L/P 24649 Fn3-67 34 rs1559410802 0.7149 None 0.995 N 0.703 0.383 0.802570031157 gnomAD-4.0.0 1.36872E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79917E-06 0 0
L/V 24649 Fn3-67 34 None 0.0821 None 0.068 N 0.477 0.042 0.423002944196 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/D 24842 Fn3-68 35 rs1708221113 0.5334 None 0.822 N 0.519 0.227 0.200317383148 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 9.41E-05 0 0 0 0
N/D 24842 Fn3-68 35 rs1708221113 0.5334 None 0.822 N 0.519 0.227 0.200317383148 gnomAD-4.0.0 2.56389E-06 None None None None I None 0 0 None 0 0 None 3.14179E-05 0 0 0 0
I/T 24941 Fn3-69 34 rs1222996660 0.058 None 0.001 N 0.168 0.076 0.319686207203 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.56E-05 0 0 0 None 0 0 0 0 0
I/T 24941 Fn3-69 34 rs1222996660 0.058 None 0.001 N 0.168 0.076 0.319686207203 gnomAD-4.0.0 4.95861E-06 None None None None I None 0 6.67111E-05 None 0 0 None 0 0 3.39094E-06 0 0
T/A 25039 Fn3-70 34 rs1272032995 0.2122 None 0.958 N 0.461 0.354 0.300784259202 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/A 25039 Fn3-70 34 rs1272032995 0.2122 None 0.958 N 0.461 0.354 0.300784259202 gnomAD-4.0.0 2.0301E-06 None None None None I None 0 0 None 0 0 None 0 0 2.40998E-06 0 0
I/K 25238 Fn3-71 35 None 0.1841 None 0.007 N 0.29 0.187 0.438913950225 gnomAD-4.0.0 2.73782E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59837E-06 0 0
I/M 25238 Fn3-71 35 rs1473998672 0.0747 -0.228 None N 0.135 0.02 0.298403945805 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.96E-06 0
I/M 25238 Fn3-71 35 rs1473998672 0.0747 -0.228 None N 0.135 0.02 0.298403945805 gnomAD-4.0.0 9.55569E-06 None None None None I None 0 0 None 0 0 None 0 2.41663E-04 2.85953E-06 0 1.21087E-04
I/V 25238 Fn3-71 35 rs1265824976 0.0674 None 0.003 N 0.142 0.155 0.354183961838 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
I/V 25238 Fn3-71 35 rs1265824976 0.0674 None 0.003 N 0.142 0.155 0.354183961838 gnomAD-4.0.0 6.57471E-06 None None None None I None 2.41196E-05 0 None 0 0 None 0 0 0 0 0
L/I 25337 Fn3-72 34 rs764447275 0.0672 -0.438 0.801 N 0.286 0.142 0.402899589544 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 0 None 0 None 0 3.57E-05 0
L/I 25337 Fn3-72 34 rs764447275 0.0672 -0.438 0.801 N 0.286 0.142 0.402899589544 gnomAD-4.0.0 6.36734E-06 None None None None I None 0 0 None 0 0 None 0 0 1.14373E-05 0 0
L/P 25337 Fn3-72 34 None 0.5882 None 0.966 N 0.387 0.415 0.783275769904 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/P 25438 Fn3-73 34 rs1707482810 0.4337 None 0.979 N 0.423 0.393 0.4018988957 gnomAD-4.0.0 1.5919E-06 None None None None I None 0 2.28697E-05 None 0 0 None 0 0 0 0 0
I/F 25731 Fn3-75 34 rs1465344199 0.1435 -0.718 0.487 N 0.369 0.151 0.495103902096 gnomAD-2.1.1 4.02E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
I/F 25731 Fn3-75 34 rs1465344199 0.1435 -0.718 0.487 N 0.369 0.151 0.495103902096 gnomAD-4.0.0 6.8434E-07 None None None None I None 2.99043E-05 0 None 0 0 None 0 0 0 0 0
I/L 25731 Fn3-75 34 None 0.0763 None None N 0.059 0.056 0.388653054685 gnomAD-4.0.0 1.36868E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79919E-06 0 0
I/T 25731 Fn3-75 34 None 0.1066 None 0.007 N 0.149 0.136 0.431490205687 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
I/T 26023 Fn3-77 34 rs572384303 0.0742 -0.882 0.001 N 0.178 0.24 0.418221603839 gnomAD-2.1.1 5.24659E-04 None None None None I None 0 0 None 0 0 None 4.21651E-03 None 0 0 1.66778E-04
I/T 26023 Fn3-77 34 rs572384303 0.0742 -0.882 0.001 N 0.178 0.24 0.418221603839 gnomAD-3.1.2 1.38092E-04 None None None None I None 0 0 0 0 0 None 0 0 0 4.34603E-03 0
I/T 26023 Fn3-77 34 rs572384303 0.0742 -0.882 0.001 N 0.178 0.24 0.418221603839 1000 genomes 1.39776E-03 None None None None I None 0 0 None None 0 0 None None None 7.2E-03 None
I/T 26023 Fn3-77 34 rs572384303 0.0742 -0.882 0.001 N 0.178 0.24 0.418221603839 gnomAD-4.0.0 2.36772E-04 None None None None I None 0 0 None 0 0 None 0 0 8.47771E-06 3.95292E-03 1.92197E-04
S/C 26320 Fn3-79 35 None 0.1579 None 0.999 N 0.706 0.47 0.504789117978 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/E 26716 Fn3-82 34 rs902372912 0.3905 None 0.557 N 0.553 0.287 0.28722502521 gnomAD-4.0.0 9.57999E-06 None None None None I None 0 0 None 0 0 None 0 0 1.25938E-05 0 0
S/I 27006 Fn3-84 35 rs886055241 0.4761 -0.115 0.007 N 0.253 0.22 0.456462010053 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
S/I 27006 Fn3-84 35 rs886055241 0.4761 -0.115 0.007 N 0.253 0.22 0.456462010053 gnomAD-4.0.0 1.59192E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85951E-06 0 0
S/R 27006 Fn3-84 35 None 0.9376 None 0.884 N 0.383 0.302 0.419957187557 gnomAD-4.0.0 3.18385E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43394E-05 3.02462E-05
I/L 27105 Fn3-85 34 None 0.071 None None N 0.053 0.059 0.330331372229 gnomAD-4.0.0 1.36912E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79938E-06 0 0
I/S 27105 Fn3-85 34 None 0.1833 None 0.012 N 0.303 0.144 0.413241256734 gnomAD-4.0.0 6.84562E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99698E-07 0 0
I/T 27105 Fn3-85 34 rs763598647 0.062 -0.906 None N 0.143 0.1 0.313818047136 gnomAD-2.1.1 4.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 9.01E-06 0
I/T 27105 Fn3-85 34 rs763598647 0.062 -0.906 None N 0.143 0.1 0.313818047136 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 27105 Fn3-85 34 rs763598647 0.062 -0.906 None N 0.143 0.1 0.313818047136 gnomAD-4.0.0 4.33993E-06 None None None None I None 0 0 None 0 0 None 0 0 5.9347E-06 0 0
T/I 27203 Fn3-86 34 rs770336276 0.3418 None 1.0 N 0.849 0.427 0.39694197178 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 27203 Fn3-86 34 rs770336276 0.3418 None 1.0 N 0.849 0.427 0.39694197178 gnomAD-4.0.0 6.57601E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47046E-05 0 0
T/K 27203 Fn3-86 34 rs770336276 0.785 -0.502 1.0 N 0.852 0.407 0.423360453849 gnomAD-2.1.1 8.12E-06 None None None None I None 0 0 None 0 0 None 6.56E-05 None 0 0 0
T/K 27203 Fn3-86 34 rs770336276 0.785 -0.502 1.0 N 0.852 0.407 0.423360453849 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07469E-04 0
T/K 27203 Fn3-86 34 rs770336276 0.785 -0.502 1.0 N 0.852 0.407 0.423360453849 gnomAD-4.0.0 5.58013E-06 None None None None I None 0 0 None 0 0 None 0 0 8.47869E-07 8.79217E-05 0
E/A 27502 Fn3-88 34 None 0.1066 None 0.805 N 0.581 0.355 0.304760801415 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
K/I 27603 Fn3-89 34 None 0.2052 None 0.029 N 0.419 0.151 0.20549828249 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/N 28088 Fn3-92 34 rs200450022 0.1676 -0.066 0.004 N 0.073 0.057 None gnomAD-2.1.1 5.93633E-04 None None None None I None 2.06697E-04 3.39924E-04 None 0 0 None 0 None 7.2023E-04 1.00997E-03 2.81294E-04
S/N 28088 Fn3-92 34 rs200450022 0.1676 -0.066 0.004 N 0.073 0.057 None gnomAD-3.1.2 6.11199E-04 None None None None I None 1.44781E-04 1.96489E-04 0 0 0 None 7.5358E-04 0 1.10262E-03 0 4.78011E-04
S/N 28088 Fn3-92 34 rs200450022 0.1676 -0.066 0.004 N 0.073 0.057 None 1000 genomes 5.99042E-04 None None None None I None 0 0 None None 0 3E-03 None None None 0 None
S/N 28088 Fn3-92 34 rs200450022 0.1676 -0.066 0.004 N 0.073 0.057 None gnomAD-4.0.0 1.23634E-03 None None None None I None 1.4662E-04 4.33391E-04 None 0 0 None 7.6584E-04 0 1.56984E-03 0 9.1235E-04
S/T 28088 Fn3-92 34 rs200450022 0.0928 None 0.472 N 0.342 0.127 0.266385636622 gnomAD-4.0.0 6.84295E-07 None None None None I None 0 0 None 0 2.52487E-05 None 0 0 0 0 0
I/T 28187 Fn3-93 34 rs1221889321 0.0592 -0.865 None N 0.146 0.079 0.315903272564 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
I/T 28187 Fn3-93 34 rs1221889321 0.0592 -0.865 None N 0.146 0.079 0.315903272564 gnomAD-4.0.0 1.59257E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86007E-06 0 0
I/V 28187 Fn3-93 34 rs2154159829 0.0754 None 0.001 N 0.087 0.035 0.313210971179 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 1.92901E-04 None 0 0 0 0 0
I/V 28187 Fn3-93 34 rs2154159829 0.0754 None 0.001 N 0.087 0.035 0.313210971179 gnomAD-4.0.0 2.0296E-06 None None None None I None 0 0 None 0 2.27221E-04 None 0 0 0 0 0
T/I 28285 Fn3-94 34 None 0.2154 None 0.976 N 0.664 0.378 0.336647302497 gnomAD-4.0.0 1.59127E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85804E-06 0 0
T/S 28285 Fn3-94 34 rs577272800 0.1974 -0.49 0.979 N 0.415 0.31 0.236890367714 gnomAD-2.1.1 4.02E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
T/S 28285 Fn3-94 34 rs577272800 0.1974 -0.49 0.979 N 0.415 0.31 0.236890367714 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/S 28285 Fn3-94 34 rs577272800 0.1974 -0.49 0.979 N 0.415 0.31 0.236890367714 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
T/S 28285 Fn3-94 34 rs577272800 0.1974 -0.49 0.979 N 0.415 0.31 0.236890367714 gnomAD-4.0.0 6.56659E-06 None None None None I None 2.40535E-05 0 None 0 0 None 0 0 0 0 0
D/E 28484 Fn3-95 35 rs768596884 0.1417 -0.44 0.835 N 0.394 0.157 0.15556083564 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
D/E 28484 Fn3-95 35 rs768596884 0.1417 -0.44 0.835 N 0.394 0.157 0.15556083564 gnomAD-4.0.0 6.8429E-07 None None None None N None 0 0 None 3.82702E-05 0 None 0 0 0 0 0
D/N 28484 Fn3-95 35 None 0.0818 -0.816 0.996 N 0.481 0.253 None gnomAD-2.1.1 2.86E-05 None None None None N None 2.06885E-04 2.83E-05 None 0 0 None 0 None 0 1.57E-05 0
D/N 28484 Fn3-95 35 None 0.0818 -0.816 0.996 N 0.481 0.253 None gnomAD-3.1.2 6.58E-05 None None None None N None 2.17307E-04 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 28484 Fn3-95 35 None 0.0818 -0.816 0.996 N 0.481 0.253 None gnomAD-4.0.0 3.34689E-05 None None None None N None 2.80441E-04 1.66822E-05 None 0 0 None 0 0 2.54285E-05 0 3.20256E-05
D/Y 28484 Fn3-95 35 rs56330345 0.151 -0.069 0.999 N 0.568 0.315 0.610467662648 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
D/Y 28484 Fn3-95 35 rs56330345 0.151 -0.069 0.999 N 0.568 0.315 0.610467662648 gnomAD-4.0.0 1.42553E-05 None None None None N None 0 0 None 0 0 None 0 0 1.94952E-05 0 0
S/C 28583 Fn3-96 34 None 0.0949 None 0.997 N 0.678 0.365 0.414930877219 gnomAD-4.0.0 6.84253E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99478E-07 0 0
S/F 28583 Fn3-96 34 rs1553562507 0.1451 None 0.97 N 0.739 0.365 0.578198000816 gnomAD-4.0.0 1.36851E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79896E-06 0 0
S/P 28583 Fn3-96 34 rs763032657 0.4836 -0.106 0.97 N 0.643 0.437 0.287603790349 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
S/P 28583 Fn3-96 34 rs763032657 0.4836 -0.106 0.97 N 0.643 0.437 0.287603790349 gnomAD-3.1.2 6.58E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
S/P 28583 Fn3-96 34 rs763032657 0.4836 -0.106 0.97 N 0.643 0.437 0.287603790349 gnomAD-4.0.0 6.81736E-06 None None None None I None 0 1.66739E-05 None 0 0 None 0 0 3.39047E-06 6.58848E-05 0
T/I 28684 Fn3-97 34 rs1703079044 0.111 None 0.032 N 0.312 0.145 0.263140351381 gnomAD-4.0.0 1.36849E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.31873E-05 0
K/R 28878 Fn3-98 34 None 0.1022 None 0.006 N 0.306 0.065 0.190952846119 gnomAD-4.0.0 1.59138E-06 None None None None I None 0 0 None 0 0 None 0 2.41313E-04 0 0 0
V/L 28975 Fn3-99 34 None 0.0896 None None N 0.098 0.094 0.326345978581 gnomAD-4.0.0 1.59137E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
T/A 29171 Fn3-100 35 rs1474922930 0.265 -0.827 0.999 N 0.579 0.542 0.388970301349 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 9.94E-05 0 None 0 None 0 0 0
T/A 29171 Fn3-100 35 rs1474922930 0.265 -0.827 0.999 N 0.579 0.542 0.388970301349 gnomAD-4.0.0 1.36834E-06 None None None None I None 0 0 None 3.82643E-05 0 None 0 0 8.99431E-07 0 0
T/S 29171 Fn3-100 35 None 0.1904 None 0.999 N 0.569 0.443 0.341226946553 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
V/I 29270 Fn3-101 34 rs141624266 0.053 -0.305 None N 0.067 0.056 None gnomAD-2.1.1 4.02322E-03 None None None None I None 3.71962E-04 2.82773E-04 None 0 5.13E-05 None 4.77093E-03 None 2.63768E-02 2.15659E-03 3.50828E-03
V/I 29270 Fn3-101 34 rs141624266 0.053 -0.305 None N 0.067 0.056 None gnomAD-3.1.2 3.13473E-03 None None None None I None 2.17161E-04 5.23629E-04 0 0 0 None 2.72333E-02 0 2.13141E-03 4.96689E-03 9.57854E-04
V/I 29270 Fn3-101 34 rs141624266 0.053 -0.305 None N 0.067 0.056 None 1000 genomes 2.59585E-03 None None None None I None 0 0 None None 0 6E-03 None None None 7.2E-03 None
V/I 29270 Fn3-101 34 rs141624266 0.053 -0.305 None N 0.067 0.056 None gnomAD-4.0.0 2.95804E-03 None None None None I None 3.99755E-04 3.16551E-04 None 3.04013E-04 4.45971E-05 None 2.69645E-02 1.48515E-03 2.01976E-03 5.08322E-03 2.12868E-03
T/I 29368 Fn3-102 34 rs757375731 0.275 -0.25 0.997 N 0.788 0.403 0.39724302092 gnomAD-2.1.1 2.01E-05 None None None None I None 0 0 None 0 0 None 1.63506E-04 None 0 0 0
T/I 29368 Fn3-102 34 rs757375731 0.275 -0.25 0.997 N 0.788 0.403 0.39724302092 gnomAD-4.0.0 7.52672E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.27545E-04 0
T/N 29567 Fn3-103 35 None 0.2169 None 1.0 N 0.788 0.435 0.442160178816 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
S/N 29666 Fn3-104 34 None 0.0807 None None N 0.097 0.102 0.110078149338 gnomAD-4.0.0 2.40065E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
I/M 29966 Fn3-106 34 rs776286853 0.0913 -0.388 0.794 N 0.303 0.111 0.437741185291 gnomAD-2.1.1 8.1E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
I/M 29966 Fn3-106 34 rs776286853 0.0913 -0.388 0.794 N 0.303 0.111 0.437741185291 gnomAD-4.0.0 2.05539E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.31889E-05 1.65695E-05
T/I 30063 Fn3-107 34 rs770325813 0.1606 0.062 0.984 N 0.467 0.369 0.441221003447 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.86E-06 0
T/I 30063 Fn3-107 34 rs770325813 0.1606 0.062 0.984 N 0.467 0.369 0.441221003447 gnomAD-3.1.2 1.31E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
T/I 30063 Fn3-107 34 rs770325813 0.1606 0.062 0.984 N 0.467 0.369 0.441221003447 gnomAD-4.0.0 2.47875E-06 None None None None I None 2.67001E-05 0 None 0 0 None 0 0 1.69522E-06 0 0
T/K 30063 Fn3-107 34 None 0.2093 None 0.896 N 0.393 0.376 0.419957187557 gnomAD-4.0.0 6.84199E-07 None None None None I None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
T/I 30357 Fn3-109 34 rs754537852 0.0923 -0.281 0.012 N 0.223 0.144 0.260735089382 gnomAD-2.1.1 1.21E-05 None None None None I None 0 2.9E-05 None 0 0 None 6.54E-05 None 0 0 0
T/I 30357 Fn3-109 34 rs754537852 0.0923 -0.281 0.012 N 0.223 0.144 0.260735089382 gnomAD-4.0.0 2.05254E-06 None None None None I None 0 2.23604E-05 None 0 0 None 0 0 0 2.31868E-05 0
V/A 30455 Fn3-110 34 rs1281249484 0.23 -1.052 0.999 N 0.601 0.289 0.5073929853 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
V/A 30455 Fn3-110 34 rs1281249484 0.23 -1.052 0.999 N 0.601 0.289 0.5073929853 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 30455 Fn3-110 34 rs1281249484 0.23 -1.052 0.999 N 0.601 0.289 0.5073929853 gnomAD-4.0.0 2.4791E-06 None None None None I None 0 0 None 0 0 None 0 0 3.39075E-06 0 0
V/M 30455 Fn3-110 34 rs766444853 0.2187 -0.305 1.0 N 0.719 0.314 0.470730462751 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
V/M 30455 Fn3-110 34 rs766444853 0.2187 -0.305 1.0 N 0.719 0.314 0.470730462751 gnomAD-4.0.0 4.79007E-06 None None None None I None 0 0 None 0 0 None 0 1.73491E-04 4.49779E-06 0 1.65667E-05
T/I 30653 Fn3-111 35 None 0.3104 None 0.638 N 0.724 0.316 0.487137410055 gnomAD-4.0.0 1.5918E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85941E-06 0 0
Q/E 30752 Fn3-112 34 rs1466048751 0.0879 None 0.047 N 0.128 0.074 0.15556083564 gnomAD-4.0.0 2.05263E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79893E-06 0 1.65656E-05
Q/H 30752 Fn3-112 34 rs1485098760 0.1378 -0.491 0.794 N 0.251 0.086 0.284539287134 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
Q/K 30752 Fn3-112 34 rs1466048751 0.0739 None None N 0.041 0.105 0.136095386433 gnomAD-4.0.0 6.84211E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99467E-07 0 0
I/T 30854 Fn3-113 34 rs368427408 0.0633 -0.987 0.008 N 0.263 0.258 None gnomAD-2.1.1 3.93E-05 None None None None I None 0 0 None 0 0 None 9.8E-05 None 0 6.25E-05 0
I/T 30854 Fn3-113 34 rs368427408 0.0633 -0.987 0.008 N 0.263 0.258 None gnomAD-3.1.2 3.29E-05 None None None None I None 0 0 0 0 0 None 0 0 7.35E-05 0 0
I/T 30854 Fn3-113 34 rs368427408 0.0633 -0.987 0.008 N 0.263 0.258 None gnomAD-4.0.0 2.16892E-05 None None None None I None 1.33508E-05 0 None 0 0 None 0 0 1.69516E-05 1.53714E-04 0
H/N 31049 Fn3-114 34 None 0.0972 None 0.822 N 0.521 0.291 0.239305524855 gnomAD-4.0.0 1.59112E-06 None None None None I None 0 0 None 0 2.77269E-05 None 0 0 0 0 0
H/Q 31049 Fn3-114 34 None 0.159 None 0.942 N 0.536 0.249 0.271763555656 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
H/Y 31049 Fn3-114 34 None 0.1134 None 0.966 N 0.527 0.371 0.357313475932 gnomAD-4.0.0 1.59112E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
T/I 31146 Fn3-115 34 None 0.153 None 0.896 N 0.391 0.269 0.390220360785 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
T/S 31146 Fn3-115 34 None 0.107 None 0.016 D 0.142 0.113 0.19670166235 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 31342 Fn3-116 35 rs1697759975 0.5956 None 0.971 N 0.778 0.405 0.48763082235 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 31342 Fn3-116 35 rs1697759975 0.5956 None 0.971 N 0.778 0.405 0.48763082235 gnomAD-4.0.0 6.81647E-06 None None None None I None 0 0 None 0 0 None 0 0 9.32342E-06 0 0
T/S 31342 Fn3-116 35 None 0.1897 None 0.058 N 0.181 0.19 0.180583059064 gnomAD-4.0.0 6.84182E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99447E-07 0 0
I/F 31441 Fn3-117 34 None 0.1249 None 0.055 N 0.36 0.133 0.45349784317 gnomAD-4.0.0 1.59124E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85842E-06 0 0
I/M 31441 Fn3-117 34 None 0.0682 None 0.171 N 0.375 0.043 0.432154444652 gnomAD-4.0.0 2.05262E-06 None None None None I None 0 0 None 0 0 None 0 0 0 3.47802E-05 0
I/T 31441 Fn3-117 34 rs1388468468 0.0558 -1.358 None N 0.156 0.104 0.247872288689 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
I/T 31441 Fn3-117 34 rs1388468468 0.0558 -1.358 None N 0.156 0.104 0.247872288689 gnomAD-4.0.0 8.21044E-06 None None None None I None 0 0 None 0 2.51915E-05 None 0 0 8.9948E-06 1.15934E-05 0
I/V 31441 Fn3-117 34 None 0.0593 None None N 0.085 0.038 0.291694819147 gnomAD-4.0.0 3.18248E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71683E-06 0 0
V/A 31539 Fn3-118 34 rs1697378195 0.2501 None 0.296 N 0.489 0.224 0.50557994651 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 0 2.07039E-04 0
V/A 31539 Fn3-118 34 rs1697378195 0.2501 None 0.296 N 0.489 0.224 0.50557994651 gnomAD-4.0.0 6.5722E-06 None None None None I None 0 0 None 0 0 None 0 0 0 2.07039E-04 0
V/E 31539 Fn3-118 34 None 0.7668 None 0.879 N 0.69 0.381 0.614395592218 gnomAD-4.0.0 1.59407E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86544E-06 0 0
V/M 31539 Fn3-118 34 rs1403013054 0.2028 None 0.782 N 0.552 0.191 0.451213972277 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/M 31539 Fn3-118 34 rs1403013054 0.2028 None 0.782 N 0.552 0.191 0.451213972277 gnomAD-4.0.0 3.84893E-06 None None None None I None 0 0 None 0 4.85437E-05 None 0 0 2.39831E-06 0 0
S/N 31840 Fn3-120 34 rs1696700303 0.0962 None None N 0.241 0.081 0.197625483188 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/N 31840 Fn3-120 34 rs1696700303 0.0962 None None N 0.241 0.081 0.197625483188 gnomAD-4.0.0 6.57194E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46977E-05 0 0
V/I 31942 Fn3-121 34 rs757627281 0.0541 -0.068 None N 0.071 0.089 0.220303561663 gnomAD-2.1.1 2.01E-05 None None None None I None 0 0 None 0 0 None 1.63399E-04 None 0 0 0
V/I 31942 Fn3-121 34 rs757627281 0.0541 -0.068 None N 0.071 0.089 0.220303561663 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/I 31942 Fn3-121 34 rs757627281 0.0541 -0.068 None N 0.071 0.089 0.220303561663 gnomAD-4.0.0 1.54935E-05 None None None None I None 0 0 None 0 2.22846E-05 None 0 1.6442E-04 1.69531E-06 2.08599E-04 3.20225E-05
N/I 32138 Fn3-122 34 None 0.1466 None 0.188 N 0.445 0.233 0.245101548738 gnomAD-4.0.0 3.19598E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71759E-06 0 0
N/K 32138 Fn3-122 34 rs933403975 0.3012 None 0.062 N 0.325 0.114 0.134241683229 gnomAD-4.0.0 4.11286E-06 None None None None I None 0 0 None 0 0 None 0 0 5.39714E-06 0 0
T/I 32235 Fn3-123 34 rs1428828704 0.1737 -0.325 0.999 N 0.806 0.434 0.421920138742 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.57E-05 None 0 None 0 0 0
T/I 32235 Fn3-123 34 rs1428828704 0.1737 -0.325 0.999 N 0.806 0.434 0.421920138742 gnomAD-4.0.0 1.59113E-06 None None None None I None 0 0 None 0 2.77254E-05 None 0 0 0 0 0
T/S 32235 Fn3-123 34 None 0.1248 None 0.825 N 0.308 0.237 0.275641507738 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 32633 Fn3-126 34 rs879182102 0.21 0.079 1.0 N 0.831 0.438 None gnomAD-2.1.1 7.13E-06 None None None None I None 8.27E-05 0 None 0 0 None 0 None 0 0 0
T/I 32633 Fn3-126 34 rs879182102 0.21 0.079 1.0 N 0.831 0.438 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 32633 Fn3-126 34 rs879182102 0.21 0.079 1.0 N 0.831 0.438 None gnomAD-4.0.0 6.57255E-06 None None None None I None 2.41336E-05 0 None 0 0 None 0 0 0 0 0
T/R 32633 Fn3-126 34 rs879182102 0.3129 None 1.0 N 0.825 0.386 0.488266720666 gnomAD-4.0.0 1.36839E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79893E-06 0 0
T/K 32930 Fn3-128 35 rs796822435 0.4523 -0.737 1.0 N 0.823 0.421 0.444807159249 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/K 32930 Fn3-128 35 rs796822435 0.4523 -0.737 1.0 N 0.823 0.421 0.444807159249 gnomAD-4.0.0 1.5913E-06 None None None None N None 0 2.28676E-05 None 0 0 None 0 0 0 0 0
L/I 33031 Fn3-129 34 None 0.0843 None 0.1 N 0.206 0.053 0.40749426699 gnomAD-4.0.0 1.59141E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43287E-05 0
R/I 33425 Fn3-131 34 None 0.2692 None 0.863 N 0.379 0.239 0.52090908611 gnomAD-4.0.0 6.93947E-07 None None None None I None 0 0 None 0 0 None 0 0 9.08188E-07 0 0
R/S 33425 Fn3-131 34 None 0.5075 None 0.029 N 0.146 0.24 0.15556083564 gnomAD-4.0.0 1.6409E-06 None None None None I None 0 0 None 0 0 None 0 0 2.94254E-06 0 0
R/T 33425 Fn3-131 34 None 0.2091 None 0.01 N 0.148 0.199 0.307966526162 gnomAD-4.0.0 6.93946E-07 None None None None I None 0 0 None 0 0 None 0 0 9.08188E-07 0 0
T/I 33722 Fn3-132 34 rs1372744849 0.1462 None 0.017 N 0.151 0.175 0.245660935333 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
T/I 33722 Fn3-132 34 rs1372744849 0.1462 None 0.017 N 0.151 0.175 0.245660935333 gnomAD-4.0.0 2.56195E-06 None None None None N None 1.69142E-05 0 None 0 0 None 0 0 0 0 2.84398E-05
T/S 33722 Fn3-132 34 None 0.1834 None 0.646 N 0.459 0.302 0.219573609325 gnomAD-4.0.0 3.18234E-06 None None None None N None 0 4.57373E-05 None 0 0 None 0 0 0 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.