Structural position:

  • Domain Type: Fn3
  • Aligned Position: 75
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand C'

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
R/S 15812 Fn3-2 55 rs794729442 0.2052 None 0.101 N 0.209 0.128 0.128392430309 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
R/S 15812 Fn3-2 55 rs794729442 0.2052 None 0.101 N 0.209 0.128 0.128392430309 gnomAD-4.0.0 6.57964E-06 None None None None N None 2.40813E-05 0 None 0 0 None 0 0 0 0 0
L/F 15913 Fn3-3 55 rs138576504 0.2778 -1.737 0.916 D 0.618 0.286 None gnomAD-2.1.1 6.57552E-04 None None None None N None 6.95994E-03 1.07735E-04 None 0 0 None 0 None 0 0 0
L/F 15913 Fn3-3 55 rs138576504 0.2778 -1.737 0.916 D 0.618 0.286 None gnomAD-3.1.2 2.05431E-03 None None None None N None 6.88306E-03 1.5746E-03 0 0 0 None 0 0 0 0 1.43541E-03
L/F 15913 Fn3-3 55 rs138576504 0.2778 -1.737 0.916 D 0.618 0.286 None 1000 genomes 2.19649E-03 None None None None N None 7.6E-03 1.4E-03 None None 0 0 None None None 0 None
L/F 15913 Fn3-3 55 rs138576504 0.2778 -1.737 0.916 D 0.618 0.286 None gnomAD-4.0.0 3.59135E-04 None None None None N None 6.82301E-03 7.21994E-04 None 0 0 None 0 1.67504E-04 2.56979E-06 0 4.0851E-04
L/P 15913 Fn3-3 55 rs1439310142 0.1368 None 0.002 N 0.369 0.081 0.495372917472 gnomAD-4.0.0 3.35425E-06 None None None None N None 0 0 None 0 0 None 0 0 5.92484E-06 0 0
P/L 16208 Fn3-5 54 rs2057137481 0.1283 None 0.012 N 0.365 0.27 0.547512163748 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
P/L 16208 Fn3-5 54 rs2057137481 0.1283 None 0.012 N 0.365 0.27 0.547512163748 gnomAD-4.0.0 6.58423E-06 None None None None N None 2.41639E-05 0 None 0 0 None 0 0 0 0 0
G/R 16604 Fn3-8 54 rs890124853 0.447 None 0.999 N 0.745 0.298 0.585534595853 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/L 16906 Fn3-11 55 rs1451657059 0.3036 -0.467 1.0 N 0.865 0.419 0.570543898189 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
P/L 16906 Fn3-11 55 rs1451657059 0.3036 -0.467 1.0 N 0.865 0.419 0.570543898189 gnomAD-4.0.0 1.59294E-06 None None None None N None 0 0 None 0 2.78056E-05 None 0 0 0 0 0
P/Q 16906 Fn3-11 55 rs1451657059 0.6802 None 1.0 D 0.833 0.497 0.430694319191 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/Q 16906 Fn3-11 55 rs1451657059 0.6802 None 1.0 D 0.833 0.497 0.430694319191 gnomAD-4.0.0 6.58484E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47249E-05 0 0
G/D 17100 Fn3-12 54 None 0.8277 None 1.0 N 0.703 0.514 0.327952845175 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/S 17100 Fn3-12 54 None 0.3111 None 1.0 N 0.694 0.412 0.267755039894 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
T/I 17424 Fn3-14 56 rs1559751874 0.6083 None 0.204 N 0.248 0.259 0.359151904892 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
T/I 17424 Fn3-14 56 rs1559751874 0.6083 None 0.204 N 0.248 0.259 0.359151904892 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 17424 Fn3-14 56 rs1559751874 0.6083 None 0.204 N 0.248 0.259 0.359151904892 gnomAD-4.0.0 2.48061E-06 None None None None I None 0 0 None 0 0 None 0 0 2.54402E-06 1.09823E-05 0
M/T 17623 Fn3-16 55 rs2055311301 0.1713 None 0.425 N 0.346 0.2 0.667830379453 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
M/T 17623 Fn3-16 55 rs2055311301 0.1713 None 0.425 N 0.346 0.2 0.667830379453 gnomAD-4.0.0 2.56481E-06 None None None None N None 1.69342E-05 0 None 0 0 None 0 0 2.39559E-06 0 0
L/F 17916 Fn3-18 55 None 0.2609 None 0.997 N 0.499 0.303 0.590672040873 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/R 17916 Fn3-18 55 rs1412322444 0.3786 -0.515 0.999 N 0.621 0.459 0.719263558215 gnomAD-2.1.1 1.43E-05 None None None None N None 8.28E-05 0 None 0 0 None 0 None 0 1.57E-05 0
L/R 17916 Fn3-18 55 rs1412322444 0.3786 -0.515 0.999 N 0.621 0.459 0.719263558215 gnomAD-3.1.2 3.29E-05 None None None None N None 9.66E-05 0 0 0 0 None 0 0 1.47E-05 0 0
L/R 17916 Fn3-18 55 rs1412322444 0.3786 -0.515 0.999 N 0.621 0.459 0.719263558215 gnomAD-4.0.0 1.15497E-05 None None None None N None 6.77805E-05 0 None 0 0 None 0 0 1.19898E-05 0 0
T/A 18120 Fn3-19 56 None 0.0759 None 0.005 N 0.157 0.101 0.1749357433 gnomAD-4.0.0 1.37054E-06 None None None None I None 0 0 None 0 0 None 0 0 9.00476E-07 1.16433E-05 0
T/S 18120 Fn3-19 56 rs770883968 0.099 -0.184 None N 0.101 0.104 0.136095386433 gnomAD-2.1.1 4.04E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
T/S 18120 Fn3-19 56 rs770883968 0.099 -0.184 None N 0.101 0.104 0.136095386433 gnomAD-4.0.0 6.8527E-07 None None None None I None 0 0 None 0 0 None 0 0 9.00476E-07 0 0
D/G 18532 Fn3-22 54 None 0.1071 None 0.001 N 0.161 0.079 0.171388866994 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
D/H 18532 Fn3-22 54 rs773425209 0.1322 -0.016 0.108 N 0.297 0.066 0.139678290688 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 5.63E-05 None 0 None 0 0 0
D/H 18532 Fn3-22 54 rs773425209 0.1322 -0.016 0.108 N 0.297 0.066 0.139678290688 gnomAD-4.0.0 1.59336E-06 None None None None I None 0 0 None 0 2.7866E-05 None 0 0 0 0 0
D/N 18532 Fn3-22 54 rs773425209 0.0557 0.438 None N 0.053 0.12 0.117506650769 gnomAD-2.1.1 1.21E-05 None None None None I None 1.94074E-04 0 None 0 0 None 0 None 0 0 0
D/N 18532 Fn3-22 54 rs773425209 0.0557 0.438 None N 0.053 0.12 0.117506650769 gnomAD-3.1.2 1.97E-05 None None None None I None 7.24E-05 0 0 0 0 None 0 0 0 0 0
D/N 18532 Fn3-22 54 rs773425209 0.0557 0.438 None N 0.053 0.12 0.117506650769 gnomAD-4.0.0 5.13138E-06 None None None None I None 6.77323E-05 0 None 0 0 None 0 0 0 0 0
D/A 18638 Fn3-23 60 rs746044045 0.2976 -0.494 1.0 N 0.789 0.454 0.393623145366 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
D/A 18638 Fn3-23 60 rs746044045 0.2976 -0.494 1.0 N 0.789 0.454 0.393623145366 gnomAD-4.0.0 6.8448E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65728E-05
D/G 18638 Fn3-23 60 None 0.3981 None 1.0 N 0.747 0.474 0.319970858106 gnomAD-4.0.0 6.8448E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99766E-07 0 0
P/S 18938 Fn3-25 55 None 0.6343 None 1.0 N 0.835 0.43 0.352048277211 gnomAD-4.0.0 6.84429E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99659E-07 0 0
E/Q 19042 Fn3-26 55 rs1471278707 0.3445 -0.266 0.928 N 0.526 0.144 0.203808441222 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
E/Q 19042 Fn3-26 55 rs1471278707 0.3445 -0.266 0.928 N 0.526 0.144 0.203808441222 gnomAD-4.0.0 1.59434E-06 None None None None N None 0 2.29158E-05 None 0 0 None 0 0 0 0 0
T/R 19237 Fn3-27 55 None 0.3327 None 0.946 N 0.712 0.45 0.636979074746 gnomAD-4.0.0 6.87372E-07 None None None None N None 0 0 None 0 0 None 0 0 9.02039E-07 0 0
A/P 19533 Fn3-29 55 rs751194562 0.702 0.015 0.667 N 0.541 0.106 0.245660935333 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
A/P 19533 Fn3-29 55 rs751194562 0.702 0.015 0.667 N 0.541 0.106 0.245660935333 gnomAD-4.0.0 3.18433E-06 None None None None I None 0 0 None 0 0 None 0 0 5.71866E-06 0 0
D/H 19631 Fn3-30 53 None 0.2962 None 0.484 N 0.397 0.208 0.198526703765 gnomAD-4.0.0 1.36872E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79924E-06 0 0
D/Y 19631 Fn3-30 53 rs565837633 0.1936 -0.27 0.741 N 0.421 0.242 0.54456359225 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 1.67485E-04 None 0 None 0 0 0
D/Y 19631 Fn3-30 53 rs565837633 0.1936 -0.27 0.741 N 0.421 0.242 0.54456359225 gnomAD-3.1.2 1.32E-05 None None None None I None 0 0 0 0 3.88802E-04 None 0 0 0 0 0
D/Y 19631 Fn3-30 53 rs565837633 0.1936 -0.27 0.741 N 0.421 0.242 0.54456359225 1000 genomes 1.99681E-04 None None None None I None 0 0 None None 1E-03 0 None None None 0 None
D/Y 19631 Fn3-30 53 rs565837633 0.1936 -0.27 0.741 N 0.421 0.242 0.54456359225 gnomAD-4.0.0 4.33893E-06 None None None None I None 0 0 None 0 1.5639E-04 None 0 0 0 0 0
T/A 19930 Fn3-32 54 rs200290906 0.0679 None 0.76 N 0.396 0.096 0.19670166235 gnomAD-4.0.0 6.84524E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99656E-07 0 0
T/I 19930 Fn3-32 54 rs748016514 0.2076 0.006 0.991 N 0.701 0.351 0.368743488249 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 0 0
T/I 19930 Fn3-32 54 rs748016514 0.2076 0.006 0.991 N 0.701 0.351 0.368743488249 gnomAD-4.0.0 4.10724E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.95814E-05 0
T/P 19930 Fn3-32 54 rs200290906 0.1476 -0.181 0.991 N 0.698 0.246 0.307648195649 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
T/P 19930 Fn3-32 54 rs200290906 0.1476 -0.181 0.991 N 0.698 0.246 0.307648195649 gnomAD-4.0.0 6.84524E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99656E-07 0 0
G/E 20225 Fn3-34 55 rs1428725715 0.3628 0.299 0.967 N 0.558 0.275 0.361160317528 gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.49E-05 0
G/E 20225 Fn3-34 55 rs1428725715 0.3628 0.299 0.967 N 0.558 0.275 0.361160317528 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
G/E 20225 Fn3-34 55 rs1428725715 0.3628 0.299 0.967 N 0.558 0.275 0.361160317528 gnomAD-4.0.0 2.56349E-06 None None None None I None 0 0 None 0 0 None 0 0 4.7887E-06 0 0
G/R 20225 Fn3-34 55 rs771598189 0.329 0.254 0.997 N 0.613 0.369 0.484545746072 gnomAD-2.1.1 2.51E-05 None None None None I None 8.27E-05 0 None 0 2.57255E-04 None 0 None 0 0 0
G/R 20225 Fn3-34 55 rs771598189 0.329 0.254 0.997 N 0.613 0.369 0.484545746072 gnomAD-3.1.2 1.32E-05 None None None None I None 2.41E-05 0 0 0 1.94401E-04 None 0 0 0 0 0
G/R 20225 Fn3-34 55 rs771598189 0.329 0.254 0.997 N 0.613 0.369 0.484545746072 gnomAD-4.0.0 1.36371E-05 None None None None I None 2.67151E-05 0 None 0 2.00947E-04 None 0 0 8.47782E-06 1.0981E-05 0
P/L 20324 Fn3-35 54 None 0.1378 None 0.999 N 0.779 0.406 0.490213675041 gnomAD-4.0.0 6.86621E-07 None None None None N None 0 0 None 0 0 None 0 0 9.02537E-07 0 0
L/F 20426 Fn3-36 56 rs377529060 0.3717 -1.431 0.217 N 0.319 0.186 0.361360026772 gnomAD-2.1.1 8.59E-05 None None None None N None 0 2.84E-05 None 0 1.03146E-03 None 0 None 0 0 4.23012E-04
L/F 20426 Fn3-36 56 rs377529060 0.3717 -1.431 0.217 N 0.319 0.186 0.361360026772 gnomAD-3.1.2 3.95E-05 None None None None N None 0 6.56E-05 0 0 9.71251E-04 None 0 0 0 0 0
L/F 20426 Fn3-36 56 rs377529060 0.3717 -1.431 0.217 N 0.319 0.186 0.361360026772 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
L/F 20426 Fn3-36 56 rs377529060 0.3717 -1.431 0.217 N 0.319 0.186 0.361360026772 gnomAD-4.0.0 2.72788E-05 None None None None N None 0 3.33745E-05 None 0 5.36481E-04 None 0 0 1.69578E-06 0 2.56205E-04
L/H 20426 Fn3-36 56 None 0.6702 None 1.0 N 0.77 0.402 0.827319285163 gnomAD-4.0.0 1.59304E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86107E-06 0 0
D/E 20622 Fn3-37 54 None 0.2729 None 0.006 N 0.179 0.108 0.259761712551 gnomAD-4.0.0 1.59201E-06 None None None None I None 0 0 None 4.76781E-05 0 None 0 0 0 0 0
S/N 20722 Fn3-38 55 rs568728579 0.2023 None 0.007 N 0.154 0.172 0.158396225186 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/N 20722 Fn3-38 55 rs568728579 0.2023 None 0.007 N 0.154 0.172 0.158396225186 gnomAD-4.0.0 2.56401E-06 None None None None N None 0 0 None 0 0 None 0 0 4.78822E-06 0 0
S/R 20722 Fn3-38 55 rs750725073 0.8764 -0.65 0.794 N 0.447 0.248 0.228597637076 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/R 20722 Fn3-38 55 rs750725073 0.8764 -0.65 0.794 N 0.447 0.248 0.228597637076 gnomAD-4.0.0 2.05309E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31922E-05 1.65673E-05
S/T 20722 Fn3-38 55 rs568728579 0.1032 -0.791 0.183 N 0.331 0.172 0.16115917748 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/T 20722 Fn3-38 55 rs568728579 0.1032 -0.791 0.183 N 0.331 0.172 0.16115917748 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07383E-04 0
S/T 20722 Fn3-38 55 rs568728579 0.1032 -0.791 0.183 N 0.331 0.172 0.16115917748 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
S/T 20722 Fn3-38 55 rs568728579 0.1032 -0.791 0.183 N 0.331 0.172 0.16115917748 gnomAD-4.0.0 6.57722E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.07555E-04 0
T/A 20917 Fn3-39 54 rs1052813873 0.0552 None None N 0.087 0.047 0.141422826196 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/A 20917 Fn3-39 54 rs1052813873 0.0552 None None N 0.087 0.047 0.141422826196 gnomAD-4.0.0 2.03009E-06 None None None None N None 0 0 None 0 0 None 0 0 1.20501E-06 4.69704E-05 0
T/S 20917 Fn3-39 54 None 0.0746 None None N 0.091 0.049 0.0611884634855 gnomAD-4.0.0 1.36973E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79955E-06 0 0
V/A 21420 Fn3-43 55 rs765213969 0.2955 -0.537 0.645 N 0.507 0.229 0.561599553422 gnomAD-2.1.1 4.02E-06 None None None None I None 6.46E-05 0 None 0 0 None 0 None 0 0 0
V/A 21420 Fn3-43 55 rs765213969 0.2955 -0.537 0.645 N 0.507 0.229 0.561599553422 gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
V/A 21420 Fn3-43 55 rs765213969 0.2955 -0.537 0.645 N 0.507 0.229 0.561599553422 gnomAD-4.0.0 6.58007E-06 None None None None I None 2.41558E-05 0 None 0 0 None 0 0 0 0 0
V/L 21420 Fn3-43 55 None 0.273 None 0.114 N 0.405 0.122 0.446913017954 gnomAD-4.0.0 1.59254E-06 None None None None I None 0 0 None 0 0 None 0 0 2.861E-06 0 0
L/F 21713 Fn3-45 55 rs759672249 0.2386 -1.336 0.171 N 0.419 0.133 0.239901079897 gnomAD-2.1.1 8.06E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
L/F 21713 Fn3-45 55 rs759672249 0.2386 -1.336 0.171 N 0.419 0.133 0.239901079897 gnomAD-4.0.0 1.59227E-06 None None None None N None 0 2.28739E-05 None 0 0 None 0 0 0 0 0
P/L 22109 Fn3-48 55 rs777960621 0.2706 -0.235 0.935 N 0.701 0.357 None gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
P/L 22109 Fn3-48 55 rs777960621 0.2706 -0.235 0.935 N 0.701 0.357 None gnomAD-4.0.0 6.15947E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19755E-06 1.15947E-05 0
A/P 22697 Fn3-52 55 None 0.8834 None 0.994 N 0.749 0.412 0.498194598333 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
A/V 22697 Fn3-52 55 None 0.3684 None 0.979 N 0.613 0.303 0.493295820912 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
P/L 22797 Fn3-53 55 rs1371471381 0.17 -0.364 1.0 N 0.801 0.422 0.690650542524 gnomAD-2.1.1 7.16E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.57E-05 0
P/L 22797 Fn3-53 55 rs1371471381 0.17 -0.364 1.0 N 0.801 0.422 0.690650542524 gnomAD-4.0.0 4.79122E-06 None None None None N None 2.99204E-05 0 None 0 2.52347E-05 None 0 0 2.69914E-06 1.15985E-05 1.65717E-05
P/Q 22797 Fn3-53 55 None 0.3759 None 0.985 N 0.398 0.367 0.502443086328 gnomAD-4.0.0 1.36892E-06 None None None None N None 0 0 None 0 2.52347E-05 None 0 0 0 1.15985E-05 0
N/D 22895 Fn3-54 55 rs2046758201 0.3439 None 0.958 N 0.399 0.397 0.315609569513 gnomAD-4.0.0 1.5921E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43345E-05 0
D/G 23093 Fn3-55 54 None 0.1219 None 0.001 N 0.108 0.149 0.132336055621 gnomAD-4.0.0 4.80129E-06 None None None None I None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
D/N 23093 Fn3-55 54 None 0.0704 None None N 0.104 0.075 0.119812018005 gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
D/V 23093 Fn3-55 54 None 0.2001 None 0.491 N 0.39 0.248 0.477762074677 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/L 23193 Fn3-56 55 None 0.1203 None 0.92 N 0.491 0.324 0.589282225109 gnomAD-4.0.0 1.5916E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02499E-05
A/D 23295 Fn3-57 56 None 0.3763 None 0.549 N 0.622 0.174 0.438278051908 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
A/T 23295 Fn3-57 56 rs746519147 0.0927 -0.972 0.009 N 0.262 0.075 None gnomAD-2.1.1 3.25E-05 None None None None N None 1.29921E-04 0 None 0 0 None 1.64658E-04 None 0 9E-06 0
A/T 23295 Fn3-57 56 rs746519147 0.0927 -0.972 0.009 N 0.262 0.075 None gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
A/T 23295 Fn3-57 56 rs746519147 0.0927 -0.972 0.009 N 0.262 0.075 None gnomAD-4.0.0 1.05453E-05 None None None None N None 5.34731E-05 0 None 0 0 None 1.56617E-05 0 2.54422E-06 8.80437E-05 1.60277E-05
K/E 23488 Fn3-58 54 None 0.1988 None 0.166 N 0.132 0.215 0.197625483188 gnomAD-4.0.0 1.36858E-06 None None None None N None 0 0 None 0 0 None 0 0 1.7991E-06 0 0
K/R 23488 Fn3-58 54 None 0.0824 None 0.166 N 0.162 0.106 0.166414681773 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/A 23780 Fn3-60 55 rs375718660 0.1248 -0.231 0.999 N 0.478 0.434 None gnomAD-2.1.1 4.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.99E-06 0
T/A 23780 Fn3-60 55 rs375718660 0.1248 -0.231 0.999 N 0.478 0.434 None gnomAD-4.0.0 1.36992E-06 None None None None I None 0 0 None 0 0 None 0 0 1.80046E-06 0 0
T/I 23780 Fn3-60 55 rs757622611 0.7122 0.104 1.0 N 0.639 0.484 0.522559126029 gnomAD-2.1.1 4.06E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.99E-06 0
T/I 23780 Fn3-60 55 rs757622611 0.7122 0.104 1.0 N 0.639 0.484 0.522559126029 gnomAD-3.1.2 6.58E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 23780 Fn3-60 55 rs757622611 0.7122 0.104 1.0 N 0.639 0.484 0.522559126029 gnomAD-4.0.0 2.03013E-06 None None None None I None 0 0 None 0 0 None 0 0 2.40995E-06 0 0
L/S 23880 Fn3-61 55 None 0.3658 None 0.942 N 0.557 0.354 0.465464902746 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/H 23978 Fn3-62 55 rs1346537219 0.1873 -0.64 1.0 N 0.708 0.495 0.252162846088 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.93E-06 0
N/H 23978 Fn3-62 55 rs1346537219 0.1873 -0.64 1.0 N 0.708 0.495 0.252162846088 gnomAD-4.0.0 1.59203E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85956E-06 0 0
E/D 24176 Fn3-63 55 rs878854331 0.0834 None None N 0.101 0.061 0.149567049428 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
E/Q 24176 Fn3-63 55 rs1553609326 0.1448 None 0.117 N 0.432 0.163 0.323615622048 gnomAD-4.0.0 1.94898E-06 None None None None N None 0 0 None 0 0 None 0 0 3.37348E-06 0 0
T/A 24276 Fn3-64 55 rs373204984 0.0687 None None N 0.065 0.067 0.0846915920261 gnomAD-4.0.0 1.40347E-06 None None None None N None 3.10713E-05 0 None 0 0 None 0 0 0 1.25257E-05 0
T/P 24276 Fn3-64 55 None 0.0608 None None N 0.245 0.146 0.0884992946249 gnomAD-4.0.0 7.01733E-07 None None None None N None 0 0 None 0 0 None 0 0 9.14406E-07 0 0
T/S 24276 Fn3-64 55 rs373204984 0.0885 -0.869 0.002 N 0.101 0.032 0.128392430309 gnomAD-2.1.1 5.98E-05 None None None None N None 0 0 None 0 0 None 0 None 0 1.27237E-04 0
T/S 24276 Fn3-64 55 rs373204984 0.0885 -0.869 0.002 N 0.101 0.032 0.128392430309 gnomAD-3.1.2 8.55E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 1.76533E-04 0 0
T/S 24276 Fn3-64 55 rs373204984 0.0885 -0.869 0.002 N 0.101 0.032 0.128392430309 gnomAD-4.0.0 1.39491E-04 None None None None N None 1.35678E-05 0 None 0 0 None 0 0 1.7218E-04 0 3.12315E-04
G/A 24378 Fn3-65 56 None 0.2088 None 0.991 N 0.633 0.266 0.168933306366 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
P/S 24962 Fn3-69 55 None 0.1668 None 0.891 N 0.379 0.172 0.251116650651 gnomAD-4.0.0 1.59183E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85935E-06 0 0
N/S 25258 Fn3-71 55 rs768945739 0.0695 0.074 None N 0.115 0.134 0.112648838833 gnomAD-2.1.1 3.24E-05 None None None None I None 0 0 None 0 0 None 0 None 0 7.17E-05 0
N/S 25258 Fn3-71 55 rs768945739 0.0695 0.074 None N 0.115 0.134 0.112648838833 gnomAD-4.0.0 1.0951E-05 None None None None I None 0 0 None 0 0 None 0 0 1.34937E-05 1.15953E-05 0
N/T 25258 Fn3-71 55 rs768945739 0.0985 0.142 0.062 N 0.301 0.091 0.176091768786 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
N/T 25258 Fn3-71 55 rs768945739 0.0985 0.142 0.062 N 0.301 0.091 0.176091768786 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
N/T 25258 Fn3-71 55 rs768945739 0.0985 0.142 0.062 N 0.301 0.091 0.176091768786 gnomAD-4.0.0 6.57479E-06 None None None None I None 2.41301E-05 0 None 0 0 None 0 0 0 0 0
L/V 25358 Fn3-72 55 None 0.0925 None 0.013 N 0.135 0.048 0.141422826196 gnomAD-4.0.0 1.59212E-06 None None None None N None 0 2.28728E-05 None 0 0 None 0 0 0 0 0
N/K 25654 Fn3-74 54 rs755800765 0.457 0.231 0.005 N 0.152 0.147 0.0297737177859 gnomAD-2.1.1 1.21E-05 None None None None N None 0 8.72E-05 None 0 0 None 0 None 0 0 0
N/K 25654 Fn3-74 54 rs755800765 0.457 0.231 0.005 N 0.152 0.147 0.0297737177859 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
N/K 25654 Fn3-74 54 rs755800765 0.457 0.231 0.005 N 0.152 0.147 0.0297737177859 gnomAD-4.0.0 6.41134E-06 None None None None N None 0 8.4832E-05 None 0 0 None 0 0 0 0 0
T/A 25944 Fn3-76 55 None 0.1247 None 0.067 N 0.217 0.13 0.15556083564 gnomAD-4.0.0 1.59192E-06 None None None None I None 0 2.28749E-05 None 0 0 None 0 0 0 0 0
I/V 26044 Fn3-77 55 rs755172743 0.055 -1.149 0.002 N 0.11 0.073 0.357519025918 gnomAD-2.1.1 3.63E-05 None None None None N None 0 0 None 0 0 None 2.94175E-04 None 0 0 0
I/V 26044 Fn3-77 55 rs755172743 0.055 -1.149 0.002 N 0.11 0.073 0.357519025918 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.06868E-04 0
I/V 26044 Fn3-77 55 rs755172743 0.055 -1.149 0.002 N 0.11 0.073 0.357519025918 gnomAD-4.0.0 6.81793E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.20776E-04 0
N/T 26142 Fn3-78 55 rs775124678 0.3381 -0.149 0.919 N 0.494 0.396 0.267755039894 gnomAD-4.0.0 4.78722E-06 None None None None N None 0 0 None 0 0 None 0 0 0 4.30231E-05 0
E/Q 26340 Fn3-79 55 None 0.1624 None 0.684 N 0.325 0.107 0.177238962908 gnomAD-4.0.0 6.84306E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99583E-07 0 0
R/C 26440 Fn3-80 55 rs55861600 0.1737 -0.487 0.997 D 0.683 0.331 None gnomAD-2.1.1 2.51621E-03 None None None None N None 2.60348E-02 1.38795E-03 None 0 0 None 2.61489E-04 None 0 8.61E-05 8.43645E-04
R/C 26440 Fn3-80 55 rs55861600 0.1737 -0.487 0.997 D 0.683 0.331 None gnomAD-3.1.2 7.51355E-03 None None None None N None 2.59991E-02 2.62398E-03 0 0 0 None 0 3.16456E-03 1.47098E-04 4.14938E-04 6.20821E-03
R/C 26440 Fn3-80 55 rs55861600 0.1737 -0.487 0.997 D 0.683 0.331 None 1000 genomes 6.58946E-03 None None None None N None 2.19E-02 4.3E-03 None None 1E-03 0 None None None 0 None
R/C 26440 Fn3-80 55 rs55861600 0.1737 -0.487 0.997 D 0.683 0.331 None gnomAD-4.0.0 1.471E-03 None None None None N None 2.69217E-02 1.7844E-03 None 0 4.46708E-05 None 0 1.1555E-03 7.54471E-05 2.08635E-04 2.09728E-03
R/H 26440 Fn3-80 55 rs56044609 0.1201 -1.351 0.096 N 0.243 0.102 None gnomAD-2.1.1 1.76438E-03 None None None None N None 1.59315E-02 1.58595E-03 None 0 0 None 5.22944E-04 None 8.08E-05 1.80087E-04 1.54625E-03
R/H 26440 Fn3-80 55 rs56044609 0.1201 -1.351 0.096 N 0.243 0.102 None gnomAD-3.1.2 5.02513E-03 None None None None N None 1.66127E-02 2.69064E-03 0 0 0 None 0 9.49367E-03 2.20614E-04 1.03648E-03 5.73066E-03
R/H 26440 Fn3-80 55 rs56044609 0.1201 -1.351 0.096 N 0.243 0.102 None 1000 genomes 4.59265E-03 None None None None N None 1.74E-02 0 None None 0 0 None None None 0 None
R/H 26440 Fn3-80 55 rs56044609 0.1201 -1.351 0.096 N 0.243 0.102 None gnomAD-4.0.0 1.05004E-03 None None None None N None 1.68031E-02 2.08479E-03 None 0 4.46488E-05 None 4.70544E-05 2.64026E-03 9.32463E-05 6.47825E-04 1.9051E-03
R/L 26440 Fn3-80 55 rs56044609 0.2142 None 0.768 N 0.59 0.33 0.415313616471 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.42E-05 0 0 0 0
R/L 26440 Fn3-80 55 rs56044609 0.2142 None 0.768 N 0.59 0.33 0.415313616471 gnomAD-4.0.0 6.5773E-06 None None None None N None 0 0 None 0 0 None 9.42152E-05 0 0 0 0
G/D 26542 Fn3-81 56 rs1308248191 0.8716 -0.749 0.999 N 0.767 0.428 0.409800938858 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
G/D 26542 Fn3-81 56 rs1308248191 0.8716 -0.749 0.999 N 0.767 0.428 0.409800938858 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/D 26542 Fn3-81 56 rs1308248191 0.8716 -0.749 0.999 N 0.767 0.428 0.409800938858 gnomAD-4.0.0 6.57678E-06 None None None None N None 2.41453E-05 0 None 0 0 None 0 0 0 0 0
G/V 26542 Fn3-81 56 rs1308248191 0.5184 None 0.995 N 0.761 0.389 0.593515057505 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
G/V 26542 Fn3-81 56 rs1308248191 0.5184 None 0.995 N 0.761 0.389 0.593515057505 gnomAD-4.0.0 6.57678E-06 None None None None N None 2.41453E-05 0 None 0 0 None 0 0 0 0 0
T/I 27026 Fn3-84 55 rs1371024440 0.7973 None 0.942 N 0.54 0.453 0.514358602855 gnomAD-4.0.0 1.59159E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.02425E-05
P/A 27126 Fn3-85 55 None 0.0778 None 0.001 N 0.161 0.132 0.211220785272 gnomAD-4.0.0 1.59452E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86302E-06 0 0
P/T 27126 Fn3-85 55 None 0.1098 None 0.183 N 0.379 0.091 0.243398259712 gnomAD-4.0.0 1.59452E-06 None None None None N None 0 0 None 0 2.78831E-05 None 0 0 0 0 0
N/S 27224 Fn3-86 55 rs368443217 0.1523 -0.782 0.999 N 0.59 0.4 None gnomAD-2.1.1 9.08E-05 None None None None N None 4.17E-05 5.74E-05 None 0 0 None 0 None 0 1.75907E-04 0
N/S 27224 Fn3-86 55 rs368443217 0.1523 -0.782 0.999 N 0.59 0.4 None gnomAD-3.1.2 1.18298E-04 None None None None N None 4.82E-05 0 0 0 0 None 0 0 2.35294E-04 0 0
N/S 27224 Fn3-86 55 rs368443217 0.1523 -0.782 0.999 N 0.59 0.4 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
N/S 27224 Fn3-86 55 rs368443217 0.1523 -0.782 0.999 N 0.59 0.4 None gnomAD-4.0.0 1.77392E-04 None None None None N None 2.66553E-05 8.37072E-05 None 0 0 None 0 0 2.21373E-04 0 2.88406E-04
E/D 27423 Fn3-87 55 rs775004192 0.0937 -0.374 0.002 N 0.109 0.102 0.107399877778 gnomAD-2.1.1 2.5E-05 None None None None N None 0 0 None 0 3.5938E-04 None 0 None 0 0 0
E/D 27423 Fn3-87 55 rs775004192 0.0937 -0.374 0.002 N 0.109 0.102 0.107399877778 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.93349E-04 None 0 0 0 0 0
E/K 27423 Fn3-87 55 rs1486346584 0.1329 0.41 0.007 N 0.113 0.146 0.168933306366 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
E/K 27423 Fn3-87 55 rs1486346584 0.1329 0.41 0.007 N 0.113 0.146 0.168933306366 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
E/K 27423 Fn3-87 55 rs1486346584 0.1329 0.41 0.007 N 0.113 0.146 0.168933306366 gnomAD-4.0.0 1.85915E-06 None None None None N None 0 0 None 0 0 None 0 0 2.54288E-06 0 0
T/K 27523 Fn3-88 55 None 0.0924 None 0.101 N 0.367 0.138 0.228597637076 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.66327E-05
G/A 27625 Fn3-89 56 None 0.3381 None 0.991 N 0.647 0.322 0.237489013734 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 0 9.19118E-04
G/A 27625 Fn3-89 56 None 0.3381 None 0.991 N 0.647 0.322 0.237489013734 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
G/A 27625 Fn3-89 56 None 0.3381 None 0.991 N 0.647 0.322 0.237489013734 gnomAD-4.0.0 1.2395E-06 None None None None N None 0 3.33467E-05 None 0 0 None 0 0 0 0 0
G/E 27625 Fn3-89 56 None 0.8636 None 0.997 N 0.789 0.449 0.469660041277 gnomAD-4.0.0 6.84249E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15945E-05 0
G/R 27625 Fn3-89 56 None 0.8464 None 0.652 N 0.615 0.367 0.512192450023 gnomAD-4.0.0 1.59144E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85874E-06 0 0
G/V 27625 Fn3-89 56 rs1466577796 0.6301 -0.528 0.999 N 0.844 0.421 0.652220884204 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 1.11607E-04 None 0 None 0 0 0
G/V 27625 Fn3-89 56 rs1466577796 0.6301 -0.528 0.999 N 0.844 0.421 0.652220884204 gnomAD-4.0.0 2.05275E-06 None None None None N None 0 0 None 0 5.0421E-05 None 0 0 8.9952E-07 0 0
A/P 28108 Fn3-92 54 None 0.709 None 0.984 N 0.561 0.288 0.318540980066 gnomAD-4.0.0 6.84287E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99507E-07 0 0
A/S 28108 Fn3-92 54 None 0.1185 None 0.64 N 0.483 0.136 0.195762928549 gnomAD-4.0.0 6.84287E-07 None None None None I None 0 0 None 0 0 None 0 0 0 0 1.65678E-05
N/D 28306 Fn3-94 55 rs758424234 0.3271 -0.518 0.581 N 0.491 0.356 0.232513804876 gnomAD-2.1.1 7.65E-05 None None None None N None 0 0 None 0 0 None 6.20915E-04 None 0 0 0
N/D 28306 Fn3-94 55 rs758424234 0.3271 -0.518 0.581 N 0.491 0.356 0.232513804876 gnomAD-4.0.0 3.48997E-05 None None None None N None 0 0 None 0 0 None 0 0 0 5.91263E-04 0
N/H 28306 Fn3-94 55 None 0.2149 None 0.968 N 0.707 0.455 0.269111216191 gnomAD-4.0.0 6.84308E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99447E-07 0 0
E/K 28504 Fn3-95 55 rs876657670 0.098 None 0.379 N 0.433 0.179 0.295623431141 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 28504 Fn3-95 55 rs876657670 0.098 None 0.379 N 0.433 0.179 0.295623431141 gnomAD-4.0.0 6.57229E-06 None None None None I None 0 0 None 0 0 None 0 0 1.46994E-05 0 0
P/T 28604 Fn3-96 55 rs1208500218 0.1086 -0.978 0.978 N 0.735 0.379 0.412328234245 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
P/T 28604 Fn3-96 55 rs1208500218 0.1086 -0.978 0.978 N 0.735 0.379 0.412328234245 gnomAD-4.0.0 1.3684E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.31868E-05 0
N/S 28898 Fn3-98 54 None 0.0693 None None N 0.101 0.098 0.0551355673512 gnomAD-4.0.0 1.36848E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79904E-06 0 0
N/Y 28898 Fn3-98 54 None 0.15 None 0.415 N 0.324 0.289 0.493628743246 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
T/A 29191 Fn3-100 55 rs963739938 0.0724 None 0.011 N 0.139 0.081 0.154104182512 gnomAD-4.0.0 6.84162E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99429E-06 0 0
T/I 29191 Fn3-100 55 rs757571814 0.5781 0.024 0.968 N 0.512 0.349 0.541330971987 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.87E-06 0
T/I 29191 Fn3-100 55 rs757571814 0.5781 0.024 0.968 N 0.512 0.349 0.541330971987 gnomAD-4.0.0 1.59102E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85786E-06 0 0
N/D 29389 Fn3-102 55 rs1343788854 0.3147 0.684 0.999 D 0.659 0.419 0.245660935333 gnomAD-2.1.1 3.18E-05 None None None None I None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
N/D 29389 Fn3-102 55 rs1343788854 0.3147 0.684 0.999 D 0.659 0.419 0.245660935333 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
N/D 29389 Fn3-102 55 rs1343788854 0.3147 0.684 0.999 D 0.659 0.419 0.245660935333 gnomAD-4.0.0 6.57142E-06 None None None None I None 2.41348E-05 0 None 0 0 None 0 0 0 0 0
N/S 29389 Fn3-102 55 rs1016296780 0.1065 None 0.999 N 0.621 0.394 0.193865811164 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
N/S 29389 Fn3-102 55 rs1016296780 0.1065 None 0.999 N 0.621 0.394 0.193865811164 gnomAD-4.0.0 7.52639E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99441E-06 0 1.65662E-05
H/L 29587 Fn3-103 55 None 0.0965 None 0.006 N 0.28 0.171 0.390060412749 gnomAD-4.0.0 6.84167E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99423E-07 0 0
H/R 29587 Fn3-103 55 rs373905959 0.0864 -0.214 0.001 N 0.103 0.13 None gnomAD-2.1.1 1.21E-05 None None None None I None 1.29149E-04 2.9E-05 None 0 0 None 0 None 0 0 0
H/R 29587 Fn3-103 55 rs373905959 0.0864 -0.214 0.001 N 0.103 0.13 None gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
H/R 29587 Fn3-103 55 rs373905959 0.0864 -0.214 0.001 N 0.103 0.13 None gnomAD-4.0.0 3.09828E-06 None None None None I None 5.33946E-05 1.66689E-05 None 0 0 None 0 0 0 0 0
H/Y 29587 Fn3-103 55 None 0.0866 None 0.081 N 0.243 0.052 0.154104182512 gnomAD-4.0.0 1.59102E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85776E-06 0 0
E/D 29789 Fn3-105 56 None 0.158 None 0.822 N 0.421 0.145 0.0920862733494 gnomAD-4.0.0 6.84189E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99447E-07 0 0
K/R 29986 Fn3-106 54 None 0.0848 None 0.026 N 0.137 0.135 0.278968121808 gnomAD-4.0.0 2.05289E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69835E-06 0 0
K/T 29986 Fn3-106 54 rs1382190597 0.1456 -0.002 0.946 N 0.475 0.35 0.328222422547 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
K/T 29986 Fn3-106 54 rs1382190597 0.1456 -0.002 0.946 N 0.475 0.35 0.328222422547 gnomAD-4.0.0 6.84295E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99449E-07 0 0
S/N 30278 Fn3-108 55 None 0.5652 None 0.999 N 0.555 0.25 0.248417906384 gnomAD-4.0.0 6.15814E-06 None None None None I None 0 0 None 0 0 None 0 0 0 8.11764E-05 3.31323E-05
S/R 30278 Fn3-108 55 rs397517751 0.9676 0.176 1.0 N 0.692 0.464 0.263612267334 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.88E-06 0
S/R 30278 Fn3-108 55 rs397517751 0.9676 0.176 1.0 N 0.692 0.464 0.263612267334 gnomAD-4.0.0 1.59138E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85834E-06 0 0
K/E 30673 Fn3-111 55 None 0.1108 None 0.027 N 0.283 0.078 0.144782658237 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/N 30673 Fn3-111 55 rs779897504 0.1188 None None N 0.125 0.117 0.0138822411134 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 5.77812E-04 None 0 0 0 0 0
K/N 30673 Fn3-111 55 rs779897504 0.1188 None None N 0.125 0.117 0.0138822411134 gnomAD-4.0.0 9.91552E-06 None None None None N None 0 0 None 0 3.56665E-04 None 0 0 0 0 0
P/A 30774 Fn3-112 56 rs1158503839 0.0871 -0.95 0.543 N 0.261 0.185 0.218112801441 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.85E-06 0
P/R 30774 Fn3-112 56 rs1399114641 0.2587 -0.26 0.998 N 0.671 0.395 0.367992661779 gnomAD-2.1.1 4.01E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
P/R 30774 Fn3-112 56 rs1399114641 0.2587 -0.26 0.998 N 0.671 0.395 0.367992661779 gnomAD-4.0.0 1.59103E-06 None None None None N None 0 2.28645E-05 None 0 0 None 0 0 0 0 0
P/T 30774 Fn3-112 56 None 0.123 None 0.978 N 0.562 0.274 0.286465849087 gnomAD-4.0.0 6.8417E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99426E-07 0 0
A/G 30875 Fn3-113 55 rs1248087390 0.1533 -0.845 None N 0.125 0.148 0.156986980423 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
A/G 30875 Fn3-113 55 rs1248087390 0.1533 -0.845 None N 0.125 0.148 0.156986980423 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/G 30875 Fn3-113 55 rs1248087390 0.1533 -0.845 None N 0.125 0.148 0.156986980423 gnomAD-4.0.0 3.22228E-05 None None None None N None 0 0 None 0 0 None 0 0 4.32258E-05 0 1.60113E-05
A/P 30875 Fn3-113 55 rs753079465 0.0938 -0.411 None N 0.272 0.051 0.0954503805726 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
A/P 30875 Fn3-113 55 rs753079465 0.0938 -0.411 None N 0.272 0.051 0.0954503805726 gnomAD-4.0.0 2.05253E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69829E-06 0 0
A/S 30875 Fn3-113 55 None 0.1062 None 0.012 N 0.385 0.027 0.0762999501168 gnomAD-4.0.0 6.84175E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99431E-07 0 0
A/T 30875 Fn3-113 55 rs753079465 0.0791 None None N 0.079 0.045 0.0846915920261 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/T 30875 Fn3-113 55 rs753079465 0.0791 None None N 0.079 0.045 0.0846915920261 gnomAD-4.0.0 1.859E-06 None None None None N None 0 0 None 0 0 None 0 0 2.5427E-06 0 0
S/G 31362 Fn3-116 55 None 0.2937 None 0.999 N 0.554 0.292 0.243398259712 gnomAD-4.0.0 3.42112E-06 None None None None I None 0 0 None 0 0 None 0 0 4.4973E-06 0 0
S/R 31362 Fn3-116 55 None 0.9776 None 1.0 N 0.787 0.511 0.318252033908 gnomAD-4.0.0 6.84218E-07 None None None None I None 0 2.23654E-05 None 0 0 None 0 0 0 0 0
P/A 31462 Fn3-117 55 None 0.1058 None 0.058 N 0.289 0.231 0.191931220699 gnomAD-4.0.0 6.84202E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99475E-07 0 0
P/S 31462 Fn3-117 55 rs1311115144 0.3495 None 0.126 N 0.267 0.219 0.199424873507 gnomAD-4.0.0 6.84202E-07 None None None None N None 0 0 None 0 2.51915E-05 None 0 0 0 0 0
P/T 31462 Fn3-117 55 rs1311115144 0.2627 -1.222 0.698 N 0.575 0.316 0.389596023526 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
P/T 31462 Fn3-117 55 rs1311115144 0.2627 -1.222 0.698 N 0.575 0.316 0.389596023526 gnomAD-4.0.0 6.5754E-06 None None None None N None 0 0 None 0 0 None 0 0 1.4702E-05 0 0
I/T 31563 Fn3-118 58 None 0.2399 None 0.007 N 0.182 0.167 0.482209950775 gnomAD-4.0.0 1.59129E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85847E-06 0 0
I/V 31563 Fn3-118 58 None 0.0725 None 0.267 N 0.189 0.168 0.580770577012 gnomAD-4.0.0 3.60097E-06 None None None None I None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
E/K 31761 Fn3-119 54 rs727505342 0.1272 -0.117 1.0 N 0.574 0.411 0.332646915603 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 3.27E-05 None 0 1.78E-05 0
E/K 31761 Fn3-119 54 rs727505342 0.1272 -0.117 1.0 N 0.574 0.411 0.332646915603 gnomAD-3.1.2 1.97E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 31761 Fn3-119 54 rs727505342 0.1272 -0.117 1.0 N 0.574 0.411 0.332646915603 gnomAD-4.0.0 9.29459E-06 None None None None I None 2.66539E-05 1.6665E-05 None 0 0 None 0 1.64962E-04 7.62842E-06 2.19578E-05 0
V/A 31862 Fn3-120 56 None 0.0878 None 0.09 N 0.212 0.15 0.469333501611 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 31964 Fn3-121 56 rs1354236675 0.1387 -0.122 0.669 N 0.412 0.168 0.44307954383 gnomAD-2.1.1 3.19E-05 None None None None N None 1.14863E-04 0 None 0 0 None 0 None 0 0 0
T/I 31964 Fn3-121 56 rs1354236675 0.1387 -0.122 0.669 N 0.412 0.168 0.44307954383 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
T/I 31964 Fn3-121 56 rs1354236675 0.1387 -0.122 0.669 N 0.412 0.168 0.44307954383 gnomAD-4.0.0 6.57869E-06 None None None None N None 2.41721E-05 0 None 0 0 None 0 0 0 0 0
T/K 31964 Fn3-121 56 rs1354236675 0.2793 None 0.801 N 0.391 0.206 0.450928719235 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/K 31964 Fn3-121 56 rs1354236675 0.2793 None 0.801 N 0.391 0.206 0.450928719235 gnomAD-4.0.0 2.47909E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39059E-06 0 0
P/L 32553 Fn3-125 55 rs765136667 0.1845 -0.308 0.761 N 0.668 0.288 None gnomAD-2.1.1 1.21E-05 None None None None N None 0 5.81E-05 None 0 0 None 0 None 0 8.89E-06 0
P/L 32553 Fn3-125 55 rs765136667 0.1845 -0.308 0.761 N 0.668 0.288 None gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
P/L 32553 Fn3-125 55 rs765136667 0.1845 -0.308 0.761 N 0.668 0.288 None gnomAD-4.0.0 4.95916E-06 None None None None N None 5.34145E-05 3.33533E-05 None 0 0 None 0 0 1.6956E-06 0 0
P/L 32654 Fn3-126 55 None 0.4806 None 1.0 N 0.878 0.424 0.7065162276 gnomAD-4.0.0 1.5912E-06 None None None None N None 5.65611E-05 0 None 0 0 None 0 0 0 0 0
R/C 33052 Fn3-129 55 rs758109676 0.3298 -1.13 1.0 N 0.785 0.306 0.420939154896 gnomAD-2.1.1 3.21E-05 None None None None N None 0 0 None 0 0 None 1.96091E-04 None 0 1.56E-05 1.40174E-04
R/C 33052 Fn3-129 55 rs758109676 0.3298 -1.13 1.0 N 0.785 0.306 0.420939154896 gnomAD-3.1.2 1.32E-05 None None None None N None 0 6.55E-05 0 0 0 None 0 0 1.47E-05 0 0
R/C 33052 Fn3-129 55 rs758109676 0.3298 -1.13 1.0 N 0.785 0.306 0.420939154896 gnomAD-4.0.0 2.72693E-05 None None None None N None 0 1.667E-05 None 0 0 None 0 0 2.54293E-05 1.31767E-04 1.60128E-05
R/H 33052 Fn3-129 55 rs72648276 0.2829 -1.85 1.0 N 0.656 0.259 None gnomAD-2.1.1 4.64E-05 None None None None N None 8.27E-05 5.65E-05 None 0 0 None 1.96091E-04 None 0 1.56E-05 1.40174E-04
R/H 33052 Fn3-129 55 rs72648276 0.2829 -1.85 1.0 N 0.656 0.259 None gnomAD-3.1.2 1.97E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 0 0
R/H 33052 Fn3-129 55 rs72648276 0.2829 -1.85 1.0 N 0.656 0.259 None gnomAD-4.0.0 1.92113E-05 None None None None N None 5.34074E-05 5E-05 None 0 0 None 0 0 9.32415E-06 1.31749E-04 1.60128E-05
R/P 33052 Fn3-129 55 rs72648276 0.5588 -0.624 0.999 N 0.784 0.356 0.37953744168 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
R/P 33052 Fn3-129 55 rs72648276 0.5588 -0.624 0.999 N 0.784 0.356 0.37953744168 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/P 33052 Fn3-129 55 rs72648276 0.5588 -0.624 0.999 N 0.784 0.356 0.37953744168 gnomAD-4.0.0 3.0986E-06 None None None None N None 2.67037E-05 0 None 0 0 None 0 0 0 3.29374E-05 0
R/S 33052 Fn3-129 55 None 0.9045 None 0.996 N 0.695 0.315 0.366848117066 gnomAD-4.0.0 6.84235E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99507E-07 0 0
A/V 33345 Fn3-130 56 rs1559064081 0.3796 None 0.565 N 0.469 0.214 0.410868550352 gnomAD-4.0.0 1.5931E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86064E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.