SAV | Position (IC) | Domain | Position (Domain) | RS | AlphaMissense (IC) |
DUET |
PolyPhen-2 |
Condel |
Rhapsody |
REVEL |
MVP |
Source |
MAF |
Disease |
Zygosity |
Site annotation |
mCSM PPI |
Predicted PPI site |
Comments |
AFR |
AMR |
AMS |
ASJ |
EAS |
EUR |
FIN |
MDE |
NFE |
SAS |
OTH |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
S/R | 15713 | Fn3-1 | 57 | rs1576516161 | 0.4525 | None | 0.968 | N | 0.59 | 0.295 | 0.229924730088 | gnomAD-4.0.0 | 1.59341E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.86243E-06 | 0 | 0 |
D/N | 15815 | Fn3-2 | 58 | rs1429370972 | 0.1092 | -0.423 | 0.822 | N | 0.489 | 0.282 | 0.227260227426 | gnomAD-2.1.1 | 4.03E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 8.91E-06 | 0 |
D/N | 15815 | Fn3-2 | 58 | rs1429370972 | 0.1092 | -0.423 | 0.822 | N | 0.489 | 0.282 | 0.227260227426 | gnomAD-4.0.0 | 4.10762E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 5.39953E-06 | 0 | 0 |
D/E | 16111 | Fn3-4 | 57 | None | 0.1791 | None | 0.014 | N | 0.251 | 0.058 | 0.0666544352282 | gnomAD-4.0.0 | 1.59582E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 1.43575E-05 | 0 |
D/N | 16111 | Fn3-4 | 57 | rs769898196 | 0.1134 | -0.307 | 0.032 | N | 0.215 | 0.13 | 0.143124449307 | gnomAD-2.1.1 | 1.21E-05 | None | None | None | None | N | None | 0 | 8.74E-05 | None | 0 | 0 | None | 0 | None | 0 | 0 | 0 |
D/N | 16111 | Fn3-4 | 57 | rs769898196 | 0.1134 | -0.307 | 0.032 | N | 0.215 | 0.13 | 0.143124449307 | gnomAD-4.0.0 | 3.42542E-06 | None | None | None | None | N | None | 0 | 6.72706E-05 | None | 0 | 0 | None | 0 | 0 | 1.80062E-06 | 0 | 0 |
D/Y | 16407 | Fn3-6 | 57 | None | 0.2643 | None | 0.989 | D | 0.441 | 0.326 | 0.570648228706 | gnomAD-4.0.0 | 1.20032E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.3125E-06 | 0 | 0 |
D/E | 16507 | Fn3-7 | 58 | None | 0.3836 | None | 1.0 | N | 0.411 | 0.229 | 0.281780670237 | gnomAD-4.0.0 | 1.20034E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.31252E-06 | 0 | 0 |
D/Y | 16507 | Fn3-7 | 58 | None | 0.6834 | None | 1.0 | N | 0.687 | 0.458 | 0.529011059296 | gnomAD-4.0.0 | 6.84825E-07 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 9.00121E-07 | 0 | 0 |
T/I | 16607 | Fn3-8 | 57 | rs747514142 | 0.2404 | 0.142 | 0.007 | N | 0.188 | 0.18 | 0.257786959452 | gnomAD-2.1.1 | 4.04E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 8.92E-06 | 0 |
T/I | 16607 | Fn3-8 | 57 | rs747514142 | 0.2404 | 0.142 | 0.007 | N | 0.188 | 0.18 | 0.257786959452 | gnomAD-4.0.0 | 3.18758E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 2.79158E-05 | None | 0 | 0 | 2.8619E-06 | 0 | 0 |
D/N | 16707 | Fn3-9 | 57 | rs1158553720 | 0.2951 | -0.557 | 0.999 | N | 0.657 | 0.223 | 0.256793551483 | gnomAD-2.1.1 | 3.19E-05 | None | None | None | None | I | None | 0 | 0 | None | 0 | 6.61376E-04 | None | 0 | None | 0 | 0 | 0 |
D/N | 16707 | Fn3-9 | 57 | rs1158553720 | 0.2951 | -0.557 | 0.999 | N | 0.657 | 0.223 | 0.256793551483 | gnomAD-3.1.2 | 6.58E-06 | None | None | None | None | I | None | 0 | 0 | 0 | 0 | 1.95313E-04 | None | 0 | 0 | 0 | 0 | 0 |
D/N | 16707 | Fn3-9 | 57 | rs1158553720 | 0.2951 | -0.557 | 0.999 | N | 0.657 | 0.223 | 0.256793551483 | gnomAD-4.0.0 | 4.34139E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 8.97787E-05 | None | 0 | 0 | 2.54401E-06 | 0 | 0 |
D/N | 16808 | Fn3-10 | 58 | None | 0.1504 | None | 0.999 | N | 0.66 | 0.291 | 0.394837016283 | gnomAD-4.0.0 | 1.20032E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.3125E-06 | 0 | 0 |
D/E | 16909 | Fn3-11 | 58 | None | 0.1607 | None | 0.198 | N | 0.217 | 0.064 | 0.1749357433 | gnomAD-4.0.0 | 1.59293E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.86149E-06 | 0 | 0 |
D/H | 16909 | Fn3-11 | 58 | rs2056319066 | 0.5304 | None | 1.0 | N | 0.681 | 0.359 | 0.350524144436 | gnomAD-3.1.2 | 6.58E-06 | None | None | None | None | I | None | 0 | 0 | 0 | 2.88184E-04 | 0 | None | 0 | 0 | 0 | 0 | 0 |
D/H | 16909 | Fn3-11 | 58 | rs2056319066 | 0.5304 | None | 1.0 | N | 0.681 | 0.359 | 0.350524144436 | gnomAD-4.0.0 | 3.84757E-06 | None | None | None | None | I | None | 0 | 0 | None | 1.2278E-04 | 0 | None | 0 | 0 | 0 | 0 | 0 |
K/E | 17103 | Fn3-12 | 57 | rs769721025 | 0.362 | -0.009 | 0.977 | N | 0.445 | 0.273 | 0.236278675362 | gnomAD-2.1.1 | 4.03E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 8.91E-06 | 0 |
K/E | 17103 | Fn3-12 | 57 | rs769721025 | 0.362 | -0.009 | 0.977 | N | 0.445 | 0.273 | 0.236278675362 | gnomAD-4.0.0 | 3.18555E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 5.72315E-06 | 0 | 0 |
K/R | 17103 | Fn3-12 | 57 | rs761668415 | 0.0928 | -0.186 | 0.235 | N | 0.235 | 0.072 | 0.24896430686 | gnomAD-2.1.1 | 4.03E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 3.27E-05 | None | 0 | 0 | 0 |
K/R | 17103 | Fn3-12 | 57 | rs761668415 | 0.0928 | -0.186 | 0.235 | N | 0.235 | 0.072 | 0.24896430686 | gnomAD-4.0.0 | 1.59277E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 1.4332E-05 | 0 |
I/V | 17204 | Fn3-13 | 58 | rs1383602491 | 0.0667 | -0.64 | None | N | 0.107 | 0.061 | 0.319402600006 | gnomAD-3.1.2 | 6.59E-06 | None | None | None | None | I | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 1.47E-05 | 0 | 0 |
I/V | 17204 | Fn3-13 | 58 | rs1383602491 | 0.0667 | -0.64 | None | N | 0.107 | 0.061 | 0.319402600006 | gnomAD-4.0.0 | 1.8601E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.54395E-06 | 0 | 0 |
H/R | 17427 | Fn3-14 | 59 | rs1387146828 | 0.143 | -0.517 | 0.029 | N | 0.253 | 0.179 | 0.245101548738 | gnomAD-2.1.1 | 4.03E-06 | None | None | None | None | I | None | 0 | 2.91E-05 | None | 0 | 0 | None | 0 | None | 0 | 0 | 0 |
H/R | 17427 | Fn3-14 | 59 | rs1387146828 | 0.143 | -0.517 | 0.029 | N | 0.253 | 0.179 | 0.245101548738 | gnomAD-4.0.0 | 1.59384E-06 | None | None | None | None | I | None | 0 | 2.28969E-05 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
A/T | 17526 | Fn3-15 | 57 | rs1313172755 | 0.0627 | -0.727 | 0.012 | N | 0.259 | 0.042 | 0.143124449307 | gnomAD-2.1.1 | 4.05E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 3.28E-05 | None | 0 | 0 | 0 |
A/T | 17526 | Fn3-15 | 57 | rs1313172755 | 0.0627 | -0.727 | 0.012 | N | 0.259 | 0.042 | 0.143124449307 | gnomAD-4.0.0 | 3.18894E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 2.86993E-05 | 0 |
V/I | 17626 | Fn3-16 | 58 | None | 0.0816 | None | None | N | 0.159 | 0.156 | 0.350088858571 | gnomAD-4.0.0 | 1.20032E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.3125E-06 | 0 | 0 |
T/A | 17919 | Fn3-18 | 58 | rs199605903 | 0.0643 | -0.517 | 0.042 | N | 0.243 | 0.239 | 0.115124310173 | gnomAD-2.1.1 | 7.15E-06 | None | None | None | None | N | None | 0 | 2.83E-05 | None | 0 | 0 | None | 0 | None | 0 | 7.83E-06 | 0 |
T/A | 17919 | Fn3-18 | 58 | rs199605903 | 0.0643 | -0.517 | 0.042 | N | 0.243 | 0.239 | 0.115124310173 | gnomAD-3.1.2 | 1.32E-05 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 2.94E-05 | 0 | 0 |
T/A | 17919 | Fn3-18 | 58 | rs199605903 | 0.0643 | -0.517 | 0.042 | N | 0.243 | 0.239 | 0.115124310173 | gnomAD-4.0.0 | 1.73665E-05 | None | None | None | None | N | None | 0 | 1.66884E-05 | None | 0 | 0 | None | 0 | 0 | 2.03579E-05 | 0 | 4.80785E-05 |
T/I | 17919 | Fn3-18 | 58 | rs1192046645 | 0.1602 | 0.018 | 0.096 | N | 0.407 | 0.236 | 0.1749357433 | gnomAD-3.1.2 | 6.58E-06 | None | None | None | None | N | None | 2.42E-05 | 0 | 0 | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
T/I | 17919 | Fn3-18 | 58 | rs1192046645 | 0.1602 | 0.018 | 0.096 | N | 0.407 | 0.236 | 0.1749357433 | gnomAD-4.0.0 | 6.58345E-06 | None | None | None | None | N | None | 2.41581E-05 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
T/N | 17919 | Fn3-18 | 58 | rs1192046645 | 0.0728 | None | None | N | 0.14 | 0.207 | 0.126345400529 | gnomAD-3.1.2 | 6.58E-06 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 1.47E-05 | 0 | 0 |
T/N | 17919 | Fn3-18 | 58 | rs1192046645 | 0.0728 | None | None | N | 0.14 | 0.207 | 0.126345400529 | gnomAD-4.0.0 | 2.03044E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.41017E-06 | 0 | 0 |
T/S | 17919 | Fn3-18 | 58 | None | 0.0725 | None | 0.042 | N | 0.286 | 0.206 | 0.101711395817 | gnomAD-4.0.0 | 6.84742E-07 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 9.00096E-07 | 0 | 0 |
E/Q | 18123 | Fn3-19 | 59 | None | 0.296 | None | 0.638 | N | 0.533 | 0.234 | 0.184867976434 | gnomAD-4.0.0 | 1.20033E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.3125E-06 | 0 | 0 |
G/D | 18228 | Fn3-20 | 63 | rs2154194670 | 0.4319 | None | 0.946 | N | 0.754 | 0.369 | 0.270447802918 | gnomAD-3.1.2 | 6.58E-06 | None | None | None | None | I | None | 2.41E-05 | 0 | 0 | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
G/D | 18228 | Fn3-20 | 63 | rs2154194670 | 0.4319 | None | 0.946 | N | 0.754 | 0.369 | 0.270447802918 | gnomAD-4.0.0 | 6.57592E-06 | None | None | None | None | I | None | 2.40639E-05 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
T/I | 18331 | Fn3-21 | 60 | rs2053691447 | 0.2034 | None | 0.497 | N | 0.675 | 0.254 | 0.499218193508 | gnomAD-4.0.0 | 1.59343E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.86207E-06 | 0 | 0 |
S/C | 18535 | Fn3-22 | 57 | rs770105954 | 0.1448 | -0.425 | 0.999 | N | 0.556 | 0.363 | 0.344945010812 | gnomAD-2.1.1 | 8.06E-06 | None | None | None | None | N | None | 0 | 5.81E-05 | None | 0 | 0 | None | 0 | None | 0 | 0 | 0 |
S/C | 18535 | Fn3-22 | 57 | rs770105954 | 0.1448 | -0.425 | 0.999 | N | 0.556 | 0.363 | 0.344945010812 | gnomAD-4.0.0 | 3.18668E-06 | None | None | None | None | N | None | 0 | 4.57917E-05 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
E/K | 18641 | Fn3-23 | 63 | None | 0.1907 | None | 0.581 | N | 0.577 | 0.182 | 0.284539287134 | gnomAD-4.0.0 | 6.84482E-07 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 1.15982E-05 | 0 |
E/K | 18841 | Fn3-24 | 58 | rs376621189 | 0.1898 | 0.242 | 0.998 | N | 0.558 | 0.378 | None | gnomAD-2.1.1 | 4.3E-06 | None | None | None | None | N | None | 6.57E-05 | 0 | None | 0 | 0 | None | 0 | None | 0 | 0 | 0 |
E/K | 18841 | Fn3-24 | 58 | rs376621189 | 0.1898 | 0.242 | 0.998 | N | 0.558 | 0.378 | None | gnomAD-3.1.2 | 1.32E-05 | None | None | None | None | N | None | 4.83E-05 | 0 | 0 | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
E/K | 18841 | Fn3-24 | 58 | rs376621189 | 0.1898 | 0.242 | 0.998 | N | 0.558 | 0.378 | None | gnomAD-4.0.0 | 2.50656E-06 | None | None | None | None | N | None | 5.41052E-05 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
G/S | 18945 | Fn3-25 | 62 | None | 0.56 | None | 1.0 | N | 0.602 | 0.413 | 0.321393169273 | gnomAD-4.0.0 | 1.59226E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 1.43324E-05 | 0 |
G/R | 19045 | Fn3-26 | 58 | rs900912009 | 0.7963 | -0.277 | 1.0 | N | 0.762 | 0.417 | 0.559961094632 | gnomAD-2.1.1 | 8.05E-06 | None | None | None | None | N | None | 0 | 0 | None | 1.98965E-04 | 0 | None | 0 | None | 0 | 0 | 0 |
G/R | 19045 | Fn3-26 | 58 | rs900912009 | 0.7963 | -0.277 | 1.0 | N | 0.762 | 0.417 | 0.559961094632 | gnomAD-3.1.2 | 6.58E-06 | None | None | None | None | N | None | 2.42E-05 | 0 | 0 | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
G/R | 19045 | Fn3-26 | 58 | rs900912009 | 0.7963 | -0.277 | 1.0 | N | 0.762 | 0.417 | 0.559961094632 | gnomAD-4.0.0 | 1.53893E-05 | None | None | None | None | N | None | 5.06928E-05 | 0 | None | 1.6372E-04 | 0 | None | 0 | 0 | 7.18497E-06 | 0 | 5.68731E-05 |
G/V | 19045 | Fn3-26 | 58 | rs1410477544 | 0.4433 | 0.429 | 1.0 | N | 0.789 | 0.455 | 0.665216195492 | gnomAD-2.1.1 | 4.03E-06 | None | None | None | None | N | None | 0 | 2.9E-05 | None | 0 | 0 | None | 0 | None | 0 | 0 | 0 |
G/V | 19045 | Fn3-26 | 58 | rs1410477544 | 0.4433 | 0.429 | 1.0 | N | 0.789 | 0.455 | 0.665216195492 | gnomAD-3.1.2 | 6.58E-06 | None | None | None | None | N | None | 0 | 6.55E-05 | 0 | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
G/V | 19045 | Fn3-26 | 58 | rs1410477544 | 0.4433 | 0.429 | 1.0 | N | 0.789 | 0.455 | 0.665216195492 | gnomAD-4.0.0 | 2.56519E-06 | None | None | None | None | N | None | 0 | 3.39236E-05 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
R/Q | 19240 | Fn3-27 | 58 | rs535940583 | 0.2467 | 0.108 | 1.0 | N | 0.699 | 0.35 | 0.21279746466 | gnomAD-2.1.1 | 4.25E-05 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 3.51247E-04 | None | 0 | 0 | 0 |
R/Q | 19240 | Fn3-27 | 58 | rs535940583 | 0.2467 | 0.108 | 1.0 | N | 0.699 | 0.35 | 0.21279746466 | gnomAD-3.1.2 | 3.95E-05 | None | None | None | None | I | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 5.88E-05 | 4.15282E-04 | 0 |
R/Q | 19240 | Fn3-27 | 58 | rs535940583 | 0.2467 | 0.108 | 1.0 | N | 0.699 | 0.35 | 0.21279746466 | 1000 genomes | 5.99042E-04 | None | None | None | None | I | None | 0 | 0 | None | None | 0 | 1E-03 | None | None | None | 2E-03 | None |
R/Q | 19240 | Fn3-27 | 58 | rs535940583 | 0.2467 | 0.108 | 1.0 | N | 0.699 | 0.35 | 0.21279746466 | gnomAD-4.0.0 | 2.49257E-05 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.02092E-05 | 2.91565E-04 | 3.21585E-05 |
S/N | 19341 | Fn3-28 | 58 | rs536645864 | 0.0788 | -0.141 | None | N | 0.083 | 0.114 | None | gnomAD-2.1.1 | 7.64E-05 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 5.88543E-04 | None | 0 | 8.88E-06 | 0 |
S/N | 19341 | Fn3-28 | 58 | rs536645864 | 0.0788 | -0.141 | None | N | 0.083 | 0.114 | None | gnomAD-3.1.2 | 1.32E-05 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 1.47E-05 | 2.07125E-04 | 0 |
S/N | 19341 | Fn3-28 | 58 | rs536645864 | 0.0788 | -0.141 | None | N | 0.083 | 0.114 | None | 1000 genomes | 1.99681E-04 | None | None | None | None | N | None | 0 | 0 | None | None | 0 | 0 | None | None | None | 1E-03 | None |
S/N | 19341 | Fn3-28 | 58 | rs536645864 | 0.0788 | -0.141 | None | N | 0.083 | 0.114 | None | gnomAD-4.0.0 | 4.71078E-05 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 1.65235E-04 | 1.01735E-05 | 6.15101E-04 | 1.12061E-04 |
K/E | 19536 | Fn3-29 | 58 | None | 0.2531 | None | 0.961 | N | 0.459 | 0.266 | 0.33340067248 | gnomAD-4.0.0 | 3.18421E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 2.86607E-05 | 0 |
Y/C | 19636 | Fn3-30 | 58 | None | 0.0898 | None | 0.873 | N | 0.563 | 0.224 | 0.462374447365 | gnomAD-4.0.0 | 1.592E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.85964E-06 | 0 | 0 |
Y/H | 19636 | Fn3-30 | 58 | None | 0.0963 | None | 0.001 | N | 0.227 | 0.089 | 0.149567049428 | gnomAD-4.0.0 | 1.20034E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.31253E-06 | 0 | 0 |
E/A | 19739 | Fn3-31 | 60 | None | 0.1268 | None | 0.565 | N | 0.546 | 0.195 | 0.264081493735 | gnomAD-4.0.0 | 1.20032E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.3125E-06 | 0 | 0 |
N/D | 20032 | Fn3-33 | 56 | rs1230376061 | 0.0842 | None | None | N | 0.083 | 0.1 | 0.0846915920261 | gnomAD-3.1.2 | 6.58E-06 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 1.47E-05 | 0 | 0 |
N/D | 20032 | Fn3-33 | 56 | rs1230376061 | 0.0842 | None | None | N | 0.083 | 0.1 | 0.0846915920261 | gnomAD-4.0.0 | 3.09934E-06 | None | None | None | None | N | None | 0 | 5.00484E-05 | None | 0 | 0 | None | 0 | 0 | 1.69554E-06 | 0 | 0 |
N/I | 20032 | Fn3-33 | 56 | None | 0.1914 | None | None | N | 0.156 | 0.252 | 0.36355261348 | gnomAD-4.0.0 | 1.20032E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.3125E-06 | 0 | 0 |
K/R | 20228 | Fn3-34 | 58 | None | 0.0785 | None | 0.27 | N | 0.281 | 0.064 | 0.238705975628 | gnomAD-4.0.0 | 1.592E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.85984E-06 | 0 | 0 |
D/E | 20327 | Fn3-35 | 57 | None | 0.1722 | None | 0.619 | N | 0.277 | 0.057 | 0.212008924253 | gnomAD-4.0.0 | 6.85362E-07 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 9.00705E-07 | 0 | 0 |
K/E | 20625 | Fn3-37 | 57 | rs2049837055 | 0.411 | None | 0.193 | N | 0.459 | 0.205 | 0.229924730088 | gnomAD-4.0.0 | 1.36869E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.79918E-06 | 0 | 0 |
T/I | 20920 | Fn3-39 | 57 | rs752337479 | 0.1266 | 0.14 | None | N | 0.181 | 0.101 | 0.250579442822 | gnomAD-2.1.1 | 3.19E-05 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 6.48E-05 | 0 |
T/I | 20920 | Fn3-39 | 57 | rs752337479 | 0.1266 | 0.14 | None | N | 0.181 | 0.101 | 0.250579442822 | gnomAD-3.1.2 | 6.58E-06 | None | None | None | None | I | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 1.47E-05 | 0 | 0 |
T/I | 20920 | Fn3-39 | 57 | rs752337479 | 0.1266 | 0.14 | None | N | 0.181 | 0.101 | 0.250579442822 | gnomAD-4.0.0 | 3.10116E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 4.2396E-06 | 0 | 0 |
T/K | 20920 | Fn3-39 | 57 | None | 0.1711 | None | 0.117 | N | 0.357 | 0.126 | 0.259272394797 | gnomAD-4.0.0 | 6.84797E-07 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 1.65826E-05 |
R/C | 21127 | Fn3-41 | 64 | rs751590336 | 0.1404 | -0.467 | 0.985 | N | 0.293 | 0.303 | 0.536240654335 | gnomAD-2.1.1 | 1.08E-05 | None | None | None | None | I | None | 0 | 2.83E-05 | None | 0 | 0 | None | 0 | None | 0 | 1.57E-05 | 0 |
R/C | 21127 | Fn3-41 | 64 | rs751590336 | 0.1404 | -0.467 | 0.985 | N | 0.293 | 0.303 | 0.536240654335 | gnomAD-4.0.0 | 7.52999E-06 | None | None | None | None | I | None | 0 | 2.23794E-05 | None | 3.82995E-05 | 0 | None | 0 | 0 | 8.09781E-06 | 0 | 0 |
R/H | 21127 | Fn3-41 | 64 | rs201226615 | 0.0995 | -1.034 | 0.004 | N | 0.133 | 0.154 | 0.158396225186 | gnomAD-2.1.1 | 1.21E-05 | None | None | None | None | I | None | 0 | 2.9E-05 | None | 0 | 0 | None | 0 | None | 4.65E-05 | 0 | 1.66223E-04 |
R/H | 21127 | Fn3-41 | 64 | rs201226615 | 0.0995 | -1.034 | 0.004 | N | 0.133 | 0.154 | 0.158396225186 | gnomAD-3.1.2 | 1.32E-05 | None | None | None | None | I | None | 2.41E-05 | 0 | 0 | 0 | 0 | None | 0 | 0 | 1.47E-05 | 0 | 0 |
R/H | 21127 | Fn3-41 | 64 | rs201226615 | 0.0995 | -1.034 | 0.004 | N | 0.133 | 0.154 | 0.158396225186 | gnomAD-4.0.0 | 1.11597E-05 | None | None | None | None | I | None | 2.66759E-05 | 1.66783E-05 | None | 0 | 4.47908E-05 | None | 1.56333E-05 | 0 | 6.78336E-06 | 1.09832E-05 | 4.804E-05 |
R/L | 21127 | Fn3-41 | 64 | rs201226615 | 0.168 | None | 0.001 | N | 0.127 | 0.232 | 0.388010793773 | gnomAD-4.0.0 | 2.05363E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.79953E-06 | 0 | 1.65739E-05 |
D/Y | 21423 | Fn3-43 | 58 | rs761820626 | 0.484 | 0.603 | 1.0 | N | 0.655 | 0.407 | 0.635861425549 | gnomAD-2.1.1 | 4.02E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 5.59E-05 | None | 0 | None | 0 | 0 | 0 |
D/Y | 21423 | Fn3-43 | 58 | rs761820626 | 0.484 | 0.603 | 1.0 | N | 0.655 | 0.407 | 0.635861425549 | gnomAD-3.1.2 | 6.58E-06 | None | None | None | None | I | None | 0 | 0 | 0 | 0 | 1.94175E-04 | None | 0 | 0 | 0 | 0 | 0 |
D/Y | 21423 | Fn3-43 | 58 | rs761820626 | 0.484 | 0.603 | 1.0 | N | 0.655 | 0.407 | 0.635861425549 | gnomAD-4.0.0 | 1.23989E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 2.23334E-05 | None | 0 | 0 | 8.47877E-07 | 0 | 0 |
K/E | 21616 | Fn3-44 | 58 | rs761445537 | 0.674 | 0.39 | 0.999 | N | 0.557 | 0.391 | 0.268660756437 | gnomAD-2.1.1 | 8.05E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 4.64E-05 | 8.91E-06 | 0 |
K/E | 21616 | Fn3-44 | 58 | rs761445537 | 0.674 | 0.39 | 0.999 | N | 0.557 | 0.391 | 0.268660756437 | gnomAD-3.1.2 | 6.58E-06 | None | None | None | None | I | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 1.47E-05 | 0 | 0 |
K/E | 21616 | Fn3-44 | 58 | rs761445537 | 0.674 | 0.39 | 0.999 | N | 0.557 | 0.391 | 0.268660756437 | gnomAD-4.0.0 | 8.97105E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 1.56858E-05 | 0 | 1.19715E-05 | 0 | 2.8456E-05 |
S/L | 21716 | Fn3-45 | 58 | rs13021201 | 0.1922 | 0.1 | 0.669 | N | 0.344 | 0.36 | None | gnomAD-2.1.1 | 2.45023E-02 | None | None | None | None | N | None | 7.73303E-03 | 1.4949E-02 | None | 1.55009E-02 | 0 | None | 1.77159E-02 | None | 1.09539E-02 | 3.92778E-02 | 2.06577E-02 |
S/L | 21716 | Fn3-45 | 58 | rs13021201 | 0.1922 | 0.1 | 0.669 | N | 0.344 | 0.36 | None | gnomAD-3.1.2 | 2.32567E-02 | None | None | None | None | N | None | 8.05985E-03 | 1.05532E-02 | 5.48246E-03 | 1.35447E-02 | 1.9425E-04 | None | 7.91408E-03 | 6.32911E-03 | 4.09899E-02 | 1.65769E-02 | 1.72084E-02 |
S/L | 21716 | Fn3-45 | 58 | rs13021201 | 0.1922 | 0.1 | 0.669 | N | 0.344 | 0.36 | None | 1000 genomes | 1.07827E-02 | None | None | None | None | N | None | 0 | 1.01E-02 | None | None | 0 | 3.68E-02 | None | None | None | 1.02E-02 | None |
S/L | 21716 | Fn3-45 | 58 | rs13021201 | 0.1922 | 0.1 | 0.669 | N | 0.344 | 0.36 | None | gnomAD-4.0.0 | 3.66102E-02 | None | None | None | None | N | None | 7.22667E-03 | 1.34883E-02 | None | 1.51085E-02 | 1.11692E-04 | None | 1.25609E-02 | 5.61241E-03 | 4.47323E-02 | 1.88924E-02 | 3.09968E-02 |
Q/L | 21816 | Fn3-46 | 60 | None | 0.0959 | None | 0.001 | N | 0.223 | 0.202 | 0.420447328233 | gnomAD-4.0.0 | 6.84874E-07 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 8.99954E-07 | 0 | 0 |
I/T | 22012 | Fn3-47 | 57 | rs1356992317 | 0.1849 | None | 0.016 | N | 0.174 | 0.237 | 0.37479162749 | gnomAD-4.0.0 | 1.59313E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.86121E-06 | 0 | 0 |
E/Q | 22112 | Fn3-48 | 58 | None | 0.5128 | None | 0.946 | N | 0.465 | 0.17 | 0.212008924253 | gnomAD-4.0.0 | 1.59214E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 1.43295E-05 | 0 |
K/Q | 22410 | Fn3-50 | 57 | rs773410270 | 0.3442 | -0.054 | 0.983 | N | 0.609 | 0.348 | 0.237489013734 | gnomAD-4.0.0 | 3.1843E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 5.55031E-05 | None | 0 | 0 | 0 | 0 | 0 |
K/T | 22410 | Fn3-50 | 57 | rs1559493839 | 0.5214 | None | 0.967 | N | 0.61 | 0.369 | 0.373897652646 | gnomAD-4.0.0 | 1.59215E-06 | None | None | None | None | N | None | 0 | 2.28707E-05 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
S/R | 22505 | Fn3-51 | 55 | None | 0.377 | None | 0.175 | N | 0.26 | 0.216 | 0.233785782151 | gnomAD-4.0.0 | 1.20032E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.3125E-06 | 0 | 0 |
K/E | 22700 | Fn3-52 | 58 | rs1401253287 | 0.5453 | 0.174 | 0.999 | N | 0.572 | 0.385 | 0.290590437066 | gnomAD-2.1.1 | 7.15E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 1.56E-05 | 0 |
K/E | 22700 | Fn3-52 | 58 | rs1401253287 | 0.5453 | 0.174 | 0.999 | N | 0.572 | 0.385 | 0.290590437066 | gnomAD-3.1.2 | 1.32E-05 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 2.94E-05 | 0 | 0 |
K/E | 22700 | Fn3-52 | 58 | rs1401253287 | 0.5453 | 0.174 | 0.999 | N | 0.572 | 0.385 | 0.290590437066 | gnomAD-4.0.0 | 4.33928E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 5.93473E-06 | 0 | 0 |
M/R | 22800 | Fn3-53 | 58 | None | 0.2369 | None | 0.873 | N | 0.378 | 0.373 | 0.565865824572 | gnomAD-4.0.0 | 1.3692E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.79994E-06 | 0 | 0 |
M/T | 22800 | Fn3-53 | 58 | rs751870146 | 0.2075 | -0.048 | 0.285 | N | 0.333 | 0.304 | 0.636921891668 | gnomAD-2.1.1 | 8.06E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 1.11707E-04 | None | 0 | None | 0 | 0 | 0 |
M/T | 22800 | Fn3-53 | 58 | rs751870146 | 0.2075 | -0.048 | 0.285 | N | 0.333 | 0.304 | 0.636921891668 | gnomAD-3.1.2 | 1.32E-05 | None | None | None | None | I | None | 0 | 0 | 0 | 0 | 3.86847E-04 | None | 0 | 0 | 0 | 0 | 0 |
M/T | 22800 | Fn3-53 | 58 | rs751870146 | 0.2075 | -0.048 | 0.285 | N | 0.333 | 0.304 | 0.636921891668 | gnomAD-4.0.0 | 1.86008E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 4.46449E-05 | None | 0 | 0 | 8.48038E-07 | 0 | 0 |
E/K | 22898 | Fn3-54 | 58 | rs1416793414 | 0.1771 | None | 0.024 | N | 0.315 | 0.133 | 0.181679512989 | gnomAD-3.1.2 | 6.57E-06 | None | None | None | None | I | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 0 | 0 | 4.78011E-04 |
E/K | 22898 | Fn3-54 | 58 | rs1416793414 | 0.1771 | None | 0.024 | N | 0.315 | 0.133 | 0.181679512989 | gnomAD-4.0.0 | 6.57471E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 4.78011E-04 |
E/Q | 22898 | Fn3-54 | 58 | rs1416793414 | 0.1482 | -0.103 | 0.055 | N | 0.327 | 0.112 | 0.170165803431 | gnomAD-2.1.1 | 3.19E-05 | None | None | None | None | I | None | 0 | 1.18203E-03 | None | 0 | 0 | None | 0 | None | 0 | 0 | 0 |
E/Q | 22898 | Fn3-54 | 58 | rs1416793414 | 0.1482 | -0.103 | 0.055 | N | 0.327 | 0.112 | 0.170165803431 | gnomAD-3.1.2 | 6.57E-06 | None | None | None | None | I | None | 0 | 6.55E-05 | 0 | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
E/Q | 22898 | Fn3-54 | 58 | rs1416793414 | 0.1482 | -0.103 | 0.055 | N | 0.327 | 0.112 | 0.170165803431 | gnomAD-4.0.0 | 6.57471E-06 | None | None | None | None | I | None | 0 | 6.54793E-05 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
S/F | 23096 | Fn3-55 | 57 | rs775422985 | 0.1583 | -1.089 | 0.295 | N | 0.375 | 0.161 | 0.598985906569 | gnomAD-2.1.1 | 2.42E-05 | None | None | None | None | N | None | 0 | 0 | None | 0 | 3.34747E-04 | None | 0 | None | 0 | 0 | 0 |
S/F | 23096 | Fn3-55 | 57 | rs775422985 | 0.1583 | -1.089 | 0.295 | N | 0.375 | 0.161 | 0.598985906569 | gnomAD-3.1.2 | 6.58E-06 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 1.94024E-04 | None | 0 | 0 | 0 | 0 | 0 |
S/F | 23096 | Fn3-55 | 57 | rs775422985 | 0.1583 | -1.089 | 0.295 | N | 0.375 | 0.161 | 0.598985906569 | gnomAD-4.0.0 | 1.61145E-05 | None | None | None | None | N | None | 0 | 0 | None | 0 | 5.80202E-04 | None | 0 | 0 | 0 | 0 | 0 |
S/P | 23096 | Fn3-55 | 57 | None | 0.4471 | None | None | N | 0.205 | 0.17 | 0.0401082797425 | gnomAD-4.0.0 | 1.20032E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.3125E-06 | 0 | 0 |
D/E | 23196 | Fn3-56 | 58 | None | 0.3908 | None | 0.979 | N | 0.456 | 0.175 | 0.170165803431 | gnomAD-4.0.0 | 1.59161E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.85922E-06 | 0 | 0 |
D/N | 23196 | Fn3-56 | 58 | rs1162141375 | 0.3513 | -0.243 | 0.999 | N | 0.665 | 0.29 | 0.219573609325 | gnomAD-2.1.1 | 8.04E-06 | None | None | None | None | N | None | 0 | 2.9E-05 | None | 0 | 0 | None | 0 | None | 0 | 8.89E-06 | 0 |
D/N | 23196 | Fn3-56 | 58 | rs1162141375 | 0.3513 | -0.243 | 0.999 | N | 0.665 | 0.29 | 0.219573609325 | gnomAD-3.1.2 | 6.58E-06 | None | None | None | None | N | None | 0 | 6.56E-05 | 0 | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
D/N | 23196 | Fn3-56 | 58 | rs1162141375 | 0.3513 | -0.243 | 0.999 | N | 0.665 | 0.29 | 0.219573609325 | gnomAD-4.0.0 | 6.81733E-06 | None | None | None | None | N | None | 1.33351E-05 | 3.33378E-05 | None | 0 | 0 | None | 0 | 0 | 4.23865E-06 | 2.19631E-05 | 1.60092E-05 |
G/R | 23587 | Fn3-59 | 56 | None | 0.4328 | None | 0.055 | N | 0.365 | 0.137 | 0.317084106153 | gnomAD-4.0.0 | 2.7372E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 3.59816E-06 | 0 | 0 |
R/C | 23783 | Fn3-60 | 58 | rs754516257 | 0.7628 | -0.353 | 1.0 | N | 0.747 | 0.457 | None | gnomAD-2.1.1 | 8.11E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 5.61E-05 | None | 0 | None | 0 | 8.98E-06 | 0 |
R/C | 23783 | Fn3-60 | 58 | rs754516257 | 0.7628 | -0.353 | 1.0 | N | 0.747 | 0.457 | None | gnomAD-4.0.0 | 4.10991E-06 | None | None | None | None | N | None | 2.98972E-05 | 0 | None | 0 | 2.52781E-05 | None | 0 | 0 | 2.70074E-06 | 1.16214E-05 | 0 |
R/H | 23783 | Fn3-60 | 58 | rs145504744 | 0.5622 | -0.872 | 1.0 | N | 0.765 | 0.402 | None | gnomAD-2.1.1 | 4.32E-05 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 3.63156E-04 | None | 0 | 7.89E-06 | 0 |
R/H | 23783 | Fn3-60 | 58 | rs145504744 | 0.5622 | -0.872 | 1.0 | N | 0.765 | 0.402 | None | gnomAD-3.1.2 | 1.32E-05 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 2.94E-05 | 0 | 0 |
R/H | 23783 | Fn3-60 | 58 | rs145504744 | 0.5622 | -0.872 | 1.0 | N | 0.765 | 0.402 | None | 1000 genomes | 1.99681E-04 | None | None | None | None | N | None | 0 | 0 | None | None | 0 | 1E-03 | None | None | None | 0 | None |
R/H | 23783 | Fn3-60 | 58 | rs145504744 | 0.5622 | -0.872 | 1.0 | N | 0.765 | 0.402 | None | gnomAD-4.0.0 | 3.28931E-05 | None | None | None | None | N | None | 1.33376E-05 | 0 | None | 0 | 0 | None | 0 | 0 | 1.35796E-05 | 3.85556E-04 | 1.6039E-05 |
R/P | 23783 | Fn3-60 | 58 | rs145504744 | 0.9904 | None | 1.0 | N | 0.697 | 0.501 | 0.514587094315 | gnomAD-3.1.2 | 6.58E-06 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 1.47E-05 | 0 | 0 |
R/P | 23783 | Fn3-60 | 58 | rs145504744 | 0.9904 | None | 1.0 | N | 0.697 | 0.501 | 0.514587094315 | gnomAD-4.0.0 | 6.57635E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.47076E-05 | 0 | 0 |
G/S | 23883 | Fn3-61 | 58 | None | 0.1332 | None | 0.997 | N | 0.675 | 0.453 | 0.267755039894 | gnomAD-4.0.0 | 3.60097E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 3.9375E-06 | 0 | 0 |
E/D | 23981 | Fn3-62 | 58 | rs1559434457 | 0.1232 | None | 0.999 | N | 0.445 | 0.191 | 0.222439326576 | gnomAD-2.1.1 | 4.03E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 8.93E-06 | 0 |
E/D | 23981 | Fn3-62 | 58 | rs1559434457 | 0.1232 | None | 0.999 | N | 0.445 | 0.191 | 0.222439326576 | gnomAD-4.0.0 | 1.59188E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.85923E-06 | 0 | 0 |
E/Q | 23981 | Fn3-62 | 58 | rs794729246 | 0.2039 | None | 1.0 | N | 0.598 | 0.24 | 0.290590437066 | gnomAD-3.1.2 | 6.57E-06 | None | None | None | None | I | None | 0 | 6.55E-05 | 0 | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
E/Q | 23981 | Fn3-62 | 58 | rs794729246 | 0.2039 | None | 1.0 | N | 0.598 | 0.24 | 0.290590437066 | gnomAD-4.0.0 | 6.57436E-06 | None | None | None | None | I | None | 0 | 6.55394E-05 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
V/I | 24179 | Fn3-63 | 58 | rs1400549364 | 0.0943 | -0.338 | None | N | 0.117 | 0.057 | 0.12205267543 | gnomAD-2.1.1 | 1E-05 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 2.01E-05 | 0 |
V/I | 24179 | Fn3-63 | 58 | rs1400549364 | 0.0943 | -0.338 | None | N | 0.117 | 0.057 | 0.12205267543 | gnomAD-3.1.2 | 1.32E-05 | None | None | None | None | I | None | 2.41E-05 | 0 | 0 | 0 | 0 | None | 0 | 0 | 1.47E-05 | 0 | 0 |
V/I | 24179 | Fn3-63 | 58 | rs1400549364 | 0.0943 | -0.338 | None | N | 0.117 | 0.057 | 0.12205267543 | gnomAD-4.0.0 | 6.67919E-06 | None | None | None | None | I | None | 1.40252E-05 | 0 | None | 0 | 0 | None | 0 | 0 | 5.32982E-06 | 0 | 5.22612E-05 |
D/E | 24279 | Fn3-64 | 58 | None | 0.3565 | None | 1.0 | N | 0.411 | 0.288 | 0.156986980423 | gnomAD-4.0.0 | 1.20032E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.3125E-06 | 0 | 0 |
D/G | 24279 | Fn3-64 | 58 | rs974475286 | 0.4832 | -0.168 | 1.0 | N | 0.725 | 0.483 | 0.331365685468 | gnomAD-2.1.1 | 8.84E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 1.9E-05 | 0 |
D/G | 24279 | Fn3-64 | 58 | rs974475286 | 0.4832 | -0.168 | 1.0 | N | 0.725 | 0.483 | 0.331365685468 | gnomAD-4.0.0 | 5.00913E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 8.95255E-06 | 0 | 0 |
D/H | 24279 | Fn3-64 | 58 | None | 0.7324 | None | 1.0 | N | 0.663 | 0.431 | 0.365892764245 | gnomAD-4.0.0 | 3.34E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.98408E-06 | 1.5466E-05 | 0 |
A/S | 24381 | Fn3-65 | 59 | rs762504227 | 0.0897 | -0.664 | 1.0 | N | 0.536 | 0.23 | 0.26547132957 | gnomAD-2.1.1 | 4.04E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 3.27E-05 | None | 0 | 0 | 0 |
A/S | 24381 | Fn3-65 | 59 | rs762504227 | 0.0897 | -0.664 | 1.0 | N | 0.536 | 0.23 | 0.26547132957 | gnomAD-4.0.0 | 1.59288E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 1.43369E-05 | 0 |
K/R | 24575 | Fn3-66 | 57 | rs766059820 | 0.1046 | -0.017 | 0.997 | N | 0.546 | 0.267 | 0.380901646489 | gnomAD-2.1.1 | 8.05E-06 | None | None | None | None | N | None | 0 | 5.8E-05 | None | 0 | 0 | None | 0 | None | 0 | 0 | 0 |
K/R | 24575 | Fn3-66 | 57 | rs766059820 | 0.1046 | -0.017 | 0.997 | N | 0.546 | 0.267 | 0.380901646489 | gnomAD-3.1.2 | 6.57E-06 | None | None | None | None | N | None | 0 | 6.55E-05 | 0 | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
K/R | 24575 | Fn3-66 | 57 | rs766059820 | 0.1046 | -0.017 | 0.997 | N | 0.546 | 0.267 | 0.380901646489 | gnomAD-4.0.0 | 3.84676E-06 | None | None | None | None | N | None | 0 | 5.08733E-05 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
V/A | 24671 | Fn3-67 | 56 | None | 0.1219 | None | 0.25 | N | 0.231 | 0.132 | 0.418344901717 | gnomAD-4.0.0 | 1.59257E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.86007E-06 | 0 | 0 |
V/I | 24671 | Fn3-67 | 56 | rs1708427922 | 0.0826 | None | 0.001 | N | 0.131 | 0.112 | 0.391313282164 | gnomAD-3.1.2 | 6.58E-06 | None | None | None | None | I | None | 0 | 6.55E-05 | 0 | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
V/I | 24671 | Fn3-67 | 56 | rs1708427922 | 0.0826 | None | 0.001 | N | 0.131 | 0.112 | 0.391313282164 | gnomAD-4.0.0 | 9.9187E-06 | None | None | None | None | I | None | 0 | 1.66778E-05 | None | 0 | 0 | None | 0 | 0 | 1.27167E-05 | 0 | 0 |
R/K | 24865 | Fn3-68 | 58 | None | 0.5725 | None | 0.773 | N | 0.481 | 0.238 | 0.230578612272 | gnomAD-4.0.0 | 1.59248E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.85959E-06 | 0 | 0 |
R/S | 24865 | Fn3-68 | 58 | rs1261180608 | 0.9768 | None | 0.099 | N | 0.343 | 0.198 | 0.154104182512 | gnomAD-3.1.2 | 6.58E-06 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 1.94099E-04 | None | 0 | 0 | 0 | 0 | 0 |
R/S | 24865 | Fn3-68 | 58 | rs1261180608 | 0.9768 | None | 0.099 | N | 0.343 | 0.198 | 0.154104182512 | gnomAD-4.0.0 | 2.56425E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 4.87116E-05 | None | 0 | 0 | 0 | 0 | 0 |
Q/H | 24965 | Fn3-69 | 58 | rs201512527 | 0.1352 | -0.263 | None | N | 0.106 | 0.114 | 0.134241683229 | gnomAD-2.1.1 | 9.93489E-04 | None | None | None | None | N | None | 0 | 7.63747E-04 | None | 1.63538E-02 | 0 | None | 0 | None | 0 | 5.71259E-04 | 1.2644E-03 |
Q/H | 24965 | Fn3-69 | 58 | rs201512527 | 0.1352 | -0.263 | None | N | 0.106 | 0.114 | 0.134241683229 | gnomAD-3.1.2 | 8.15285E-04 | None | None | None | None | N | None | 1.20662E-04 | 5.90396E-04 | 0 | 1.78777E-02 | 0 | None | 0 | 0 | 6.3226E-04 | 0 | 2.39006E-03 |
Q/H | 24965 | Fn3-69 | 58 | rs201512527 | 0.1352 | -0.263 | None | N | 0.106 | 0.114 | 0.134241683229 | 1000 genomes | 3.99361E-04 | None | None | None | None | N | None | 0 | 1.4E-03 | None | None | 0 | 1E-03 | None | None | None | 0 | None |
Q/H | 24965 | Fn3-69 | 58 | rs201512527 | 0.1352 | -0.263 | None | N | 0.106 | 0.114 | 0.134241683229 | gnomAD-4.0.0 | 9.06086E-04 | None | None | None | None | N | None | 1.06661E-04 | 7.83647E-04 | None | 1.67624E-02 | 0 | None | 0 | 0 | 6.76479E-04 | 0 | 1.80898E-03 |
Q/R | 24965 | Fn3-69 | 58 | None | 0.1157 | None | 0.024 | N | 0.122 | 0.102 | 0.154104182512 | gnomAD-4.0.0 | 1.20032E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.3125E-06 | 0 | 0 |
D/H | 25063 | Fn3-70 | 58 | rs1707970781 | 0.3511 | None | 0.602 | N | 0.329 | 0.259 | 0.190952846119 | gnomAD-4.0.0 | 1.59169E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.85928E-06 | 0 | 0 |
K/Q | 25657 | Fn3-74 | 57 | None | 0.2226 | None | 0.897 | N | 0.531 | 0.197 | 0.1749357433 | gnomAD-4.0.0 | 1.59245E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.86031E-06 | 0 | 0 |
K/T | 25657 | Fn3-74 | 57 | None | 0.4209 | None | 0.978 | N | 0.552 | 0.287 | 0.309530620856 | gnomAD-4.0.0 | 2.40064E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 1.21507E-04 | 0 |
S/A | 25753 | Fn3-75 | 56 | None | 0.0772 | None | None | N | 0.08 | 0.066 | 0.0954503805726 | gnomAD-4.0.0 | 3.60098E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 3.93752E-06 | 0 | 0 |
S/Y | 25753 | Fn3-75 | 56 | rs1286606791 | 0.1968 | -0.402 | 0.912 | N | 0.377 | 0.26 | 0.528009843598 | gnomAD-2.1.1 | 4.03E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 8.88E-06 | 0 |
S/Y | 25753 | Fn3-75 | 56 | rs1286606791 | 0.1968 | -0.402 | 0.912 | N | 0.377 | 0.26 | 0.528009843598 | gnomAD-4.0.0 | 2.73806E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 3.59846E-06 | 0 | 0 |
R/G | 25947 | Fn3-76 | 58 | rs369737926 | 0.9283 | -0.153 | 0.892 | N | 0.571 | 0.332 | None | gnomAD-2.1.1 | 4.02E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 8.88E-06 | 0 |
R/G | 25947 | Fn3-76 | 58 | rs369737926 | 0.9283 | -0.153 | 0.892 | N | 0.571 | 0.332 | None | gnomAD-4.0.0 | 3.60098E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 3.93752E-06 | 0 | 0 |
R/S | 25947 | Fn3-76 | 58 | rs1706725757 | 0.9803 | None | 0.892 | N | 0.657 | 0.3 | 0.321951552304 | gnomAD-3.1.2 | 6.57E-06 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 1.47E-05 | 0 | 0 |
R/S | 25947 | Fn3-76 | 58 | rs1706725757 | 0.9803 | None | 0.892 | N | 0.657 | 0.3 | 0.321951552304 | gnomAD-4.0.0 | 3.09903E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 4.23858E-06 | 0 | 0 |
D/H | 26047 | Fn3-77 | 58 | rs1315662301 | 0.335 | None | 0.942 | D | 0.652 | 0.279 | 0.285698343383 | gnomAD-4.0.0 | 6.84331E-07 | None | None | None | None | I | None | 0 | 2.23704E-05 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
D/N | 26047 | Fn3-77 | 58 | rs1315662301 | 0.1008 | -0.191 | 0.942 | N | 0.545 | 0.256 | 0.233785782151 | gnomAD-2.1.1 | 4.03E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 3.27E-05 | None | 0 | 0 | 0 |
D/N | 26047 | Fn3-77 | 58 | rs1315662301 | 0.1008 | -0.191 | 0.942 | N | 0.545 | 0.256 | 0.233785782151 | gnomAD-4.0.0 | 2.73732E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 4.63811E-05 | 0 |
E/K | 26145 | Fn3-78 | 58 | rs1405668603 | 0.4644 | 0.413 | 0.939 | N | 0.487 | 0.32 | 0.303781844768 | gnomAD-2.1.1 | 4.04E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 8.95E-06 | 0 |
T/I | 26343 | Fn3-79 | 58 | rs765936549 | 0.2031 | 0.131 | 0.934 | N | 0.42 | 0.444 | 0.419090007872 | gnomAD-2.1.1 | 7.15E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 1.57E-05 | 0 |
T/I | 26343 | Fn3-79 | 58 | rs765936549 | 0.2031 | 0.131 | 0.934 | N | 0.42 | 0.444 | 0.419090007872 | gnomAD-3.1.2 | 2.63E-05 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 5.88E-05 | 0 | 0 |
T/I | 26343 | Fn3-79 | 58 | rs765936549 | 0.2031 | 0.131 | 0.934 | N | 0.42 | 0.444 | 0.419090007872 | gnomAD-4.0.0 | 4.21473E-05 | None | None | None | None | N | None | 0 | 1.66772E-05 | None | 0 | 0 | None | 0 | 0 | 5.67985E-05 | 0 | 0 |
V/A | 26835 | Fn3-83 | 56 | rs1705503390 | 0.1082 | None | 0.009 | N | 0.102 | 0.125 | 0.394685799254 | gnomAD-4.0.0 | 1.59161E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 2.77331E-05 | None | 0 | 0 | 0 | 0 | 0 |
D/E | 27129 | Fn3-85 | 58 | None | 0.1326 | None | 0.767 | N | 0.275 | 0.091 | 0.146414634003 | gnomAD-4.0.0 | 6.84659E-07 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 8.99798E-07 | 0 | 0 |
D/H | 27129 | Fn3-85 | 58 | rs778910088 | 0.3614 | 0.521 | 1.0 | N | 0.731 | 0.345 | 0.313518423057 | gnomAD-2.1.1 | 8.12E-06 | None | None | None | None | N | None | 0 | 5.85E-05 | None | 0 | 0 | None | 0 | None | 0 | 0 | 0 |
D/H | 27129 | Fn3-85 | 58 | rs778910088 | 0.3614 | 0.521 | 1.0 | N | 0.731 | 0.345 | 0.313518423057 | gnomAD-4.0.0 | 3.18747E-06 | None | None | None | None | N | None | 0 | 4.5861E-05 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
A/D | 27426 | Fn3-87 | 58 | rs774473418 | 0.3708 | -1.459 | 0.967 | N | 0.675 | 0.47 | 0.555788435936 | gnomAD-2.1.1 | 4.02E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 5.58E-05 | None | 0 | None | 0 | 0 | 0 |
A/G | 27426 | Fn3-87 | 58 | None | 0.1317 | None | 0.805 | N | 0.401 | 0.351 | 0.388174495139 | gnomAD-3.1.2 | 6.57E-06 | None | None | None | None | N | None | 0 | 6.56E-05 | 0 | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
A/G | 27426 | Fn3-87 | 58 | None | 0.1317 | None | 0.805 | N | 0.401 | 0.351 | 0.388174495139 | gnomAD-4.0.0 | 6.57471E-06 | None | None | None | None | N | None | 0 | 6.55738E-05 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
A/V | 27426 | Fn3-87 | 58 | rs774473418 | 0.1329 | -0.02 | 0.892 | N | 0.453 | 0.324 | 0.44153150616 | gnomAD-2.1.1 | 1.61E-05 | None | None | None | None | N | None | 0 | 2.9E-05 | None | 0 | 0 | None | 0 | None | 9.28E-05 | 8.89E-06 | 0 |
A/V | 27426 | Fn3-87 | 58 | rs774473418 | 0.1329 | -0.02 | 0.892 | N | 0.453 | 0.324 | 0.44153150616 | gnomAD-3.1.2 | 6.57E-06 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 9.41E-05 | 0 | 0 | 0 | 0 |
A/V | 27426 | Fn3-87 | 58 | rs774473418 | 0.1329 | -0.02 | 0.892 | N | 0.453 | 0.324 | 0.44153150616 | gnomAD-4.0.0 | 1.40937E-05 | None | None | None | None | N | None | 0 | 5.08595E-05 | None | 0 | 0 | None | 1.09811E-04 | 0 | 2.3932E-06 | 0 | 0 |
G/R | 27628 | Fn3-89 | 59 | rs773909467 | 0.3357 | -0.312 | 0.984 | N | 0.689 | 0.281 | 0.456089687795 | gnomAD-2.1.1 | 4.03E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 3.27E-05 | None | 0 | 0 | 0 |
K/E | 27822 | Fn3-90 | 57 | rs1269206431 | 0.5103 | 0.221 | 0.948 | N | 0.43 | 0.239 | 0.259272394797 | gnomAD-2.1.1 | 4.3E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 9.27E-06 | 0 |
T/S | 27918 | Fn3-91 | 56 | None | 0.0857 | None | 0.309 | N | 0.309 | 0.106 | 0.168933306366 | gnomAD-4.0.0 | 1.59739E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.865E-06 | 0 | 0 |
R/K | 28111 | Fn3-92 | 57 | rs1060500463 | 0.3358 | None | 0.773 | N | 0.517 | 0.2 | 0.335910606209 | gnomAD-4.0.0 | 3.1835E-06 | None | None | None | None | N | None | 5.65675E-05 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 3.02499E-05 |
D/G | 28211 | Fn3-93 | 58 | rs1168835158 | 0.1586 | -0.424 | 0.338 | N | 0.417 | 0.217 | 0.185906805712 | gnomAD-2.1.1 | 4.02E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 8.88E-06 | 0 |
D/G | 28211 | Fn3-93 | 58 | rs1168835158 | 0.1586 | -0.424 | 0.338 | N | 0.417 | 0.217 | 0.185906805712 | gnomAD-3.1.2 | 6.57E-06 | None | None | None | None | I | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 1.47E-05 | 0 | 0 |
D/G | 28211 | Fn3-93 | 58 | rs1168835158 | 0.1586 | -0.424 | 0.338 | N | 0.417 | 0.217 | 0.185906805712 | gnomAD-4.0.0 | 3.71838E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.54293E-06 | 0 | 4.80323E-05 |
D/N | 28211 | Fn3-93 | 58 | rs777440731 | 0.1064 | -0.146 | 0.003 | N | 0.169 | 0.166 | 0.137902524267 | gnomAD-2.1.1 | 1.07E-05 | None | None | None | None | I | None | 0 | 0 | None | 0 | 1.54289E-04 | None | 0 | None | 0 | 0 | 0 |
D/N | 28211 | Fn3-93 | 58 | rs777440731 | 0.1064 | -0.146 | 0.003 | N | 0.169 | 0.166 | 0.137902524267 | gnomAD-3.1.2 | 6.57E-06 | None | None | None | None | I | None | 0 | 0 | 0 | 0 | 1.93349E-04 | None | 0 | 0 | 0 | 0 | 0 |
D/N | 28211 | Fn3-93 | 58 | rs777440731 | 0.1064 | -0.146 | 0.003 | N | 0.169 | 0.166 | 0.137902524267 | gnomAD-4.0.0 | 6.57237E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 1.93349E-04 | None | 0 | 0 | 0 | 0 | 0 |
E/K | 28309 | Fn3-94 | 58 | rs1383001734 | 0.321 | 0.134 | 0.994 | N | 0.431 | 0.371 | 0.340510301474 | gnomAD-2.1.1 | 4.03E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 8.91E-06 | 0 |
M/I | 28507 | Fn3-95 | 58 | None | 0.1685 | None | 0.001 | N | 0.165 | 0.031 | 0.0954503805726 | gnomAD-4.0.0 | 6.84347E-07 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 8.99488E-07 | 0 | 0 |
M/V | 28507 | Fn3-95 | 58 | rs750081245 | 0.0771 | 0.035 | None | N | 0.062 | 0.091 | 0.239305524855 | gnomAD-2.1.1 | 1.07E-05 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 2.36E-05 | 0 |
M/V | 28507 | Fn3-95 | 58 | rs750081245 | 0.0771 | 0.035 | None | N | 0.062 | 0.091 | 0.239305524855 | gnomAD-3.1.2 | 6.57E-06 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 1.47E-05 | 0 | 0 |
M/V | 28507 | Fn3-95 | 58 | rs750081245 | 0.0771 | 0.035 | None | N | 0.062 | 0.091 | 0.239305524855 | gnomAD-4.0.0 | 5.12587E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 1.57178E-05 | 0 | 7.17899E-06 | 0 | 0 |
D/E | 28607 | Fn3-96 | 58 | None | 0.542 | None | 1.0 | N | 0.411 | 0.211 | 0.185906805712 | gnomAD-4.0.0 | 1.5913E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.85829E-06 | 0 | 0 |
D/H | 28607 | Fn3-96 | 58 | rs879085011 | 0.7553 | None | 1.0 | N | 0.675 | 0.472 | None | gnomAD-3.1.2 | 6.57E-06 | None | None | None | None | N | None | 2.41E-05 | 0 | 0 | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
D/H | 28607 | Fn3-96 | 58 | rs879085011 | 0.7553 | None | 1.0 | N | 0.675 | 0.472 | None | gnomAD-4.0.0 | 6.57333E-06 | None | None | None | None | N | None | 2.41289E-05 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
G/E | 28707 | Fn3-97 | 57 | rs754207859 | 0.2673 | -0.463 | 0.684 | N | 0.338 | 0.239 | None | gnomAD-2.1.1 | 2.83E-05 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 5.38E-05 | 1.66445E-04 |
G/E | 28707 | Fn3-97 | 57 | rs754207859 | 0.2673 | -0.463 | 0.684 | N | 0.338 | 0.239 | None | gnomAD-3.1.2 | 6.58E-06 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 1.47E-05 | 0 | 0 |
G/E | 28707 | Fn3-97 | 57 | rs754207859 | 0.2673 | -0.463 | 0.684 | N | 0.338 | 0.239 | None | gnomAD-4.0.0 | 4.89609E-05 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 6.61129E-05 | 0 | 1.60118E-05 |
R/C | 28901 | Fn3-98 | 57 | rs757848764 | 0.1779 | -0.06 | 1.0 | N | 0.73 | 0.335 | 0.613652031552 | gnomAD-2.1.1 | 1.21E-05 | None | None | None | None | N | None | 0 | 0 | None | 0 | 5.58E-05 | None | 0 | None | 0 | 1.78E-05 | 0 |
R/C | 28901 | Fn3-98 | 57 | rs757848764 | 0.1779 | -0.06 | 1.0 | N | 0.73 | 0.335 | 0.613652031552 | gnomAD-3.1.2 | 1.97E-05 | None | None | None | None | N | None | 2.41E-05 | 0 | 0 | 0 | 0 | None | 0 | 0 | 1.47E-05 | 0 | 4.78011E-04 |
R/C | 28901 | Fn3-98 | 57 | rs757848764 | 0.1779 | -0.06 | 1.0 | N | 0.73 | 0.335 | 0.613652031552 | gnomAD-4.0.0 | 1.23951E-05 | None | None | None | None | N | None | 4.0063E-05 | 1.66728E-05 | None | 0 | 8.91424E-05 | None | 0 | 0 | 6.78129E-06 | 1.09832E-05 | 4.80354E-05 |
R/G | 28901 | Fn3-98 | 57 | rs757848764 | 0.2857 | None | 1.0 | N | 0.611 | 0.275 | 0.543299242062 | gnomAD-4.0.0 | 6.84262E-07 | None | None | None | None | N | None | 0 | 2.23614E-05 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
R/H | 28901 | Fn3-98 | 57 | rs550229338 | 0.1029 | -0.746 | 1.0 | N | 0.76 | 0.331 | 0.254761474806 | gnomAD-2.1.1 | 5.23E-05 | None | None | None | None | N | None | 0 | 2.9E-05 | None | 0 | 6.13908E-04 | None | 3.27E-05 | None | 0 | 0 | 0 |
R/H | 28901 | Fn3-98 | 57 | rs550229338 | 0.1029 | -0.746 | 1.0 | N | 0.76 | 0.331 | 0.254761474806 | gnomAD-3.1.2 | 1.97E-05 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 5.78258E-04 | None | 0 | 0 | 0 | 0 | 0 |
R/H | 28901 | Fn3-98 | 57 | rs550229338 | 0.1029 | -0.746 | 1.0 | N | 0.76 | 0.331 | 0.254761474806 | 1000 genomes | 3.99361E-04 | None | None | None | None | N | None | 0 | 0 | None | None | 2E-03 | 0 | None | None | None | 0 | None |
R/H | 28901 | Fn3-98 | 57 | rs550229338 | 0.1029 | -0.746 | 1.0 | N | 0.76 | 0.331 | 0.254761474806 | gnomAD-4.0.0 | 1.36333E-05 | None | None | None | None | N | None | 0 | 1.66656E-05 | None | 3.37883E-05 | 2.8979E-04 | None | 0 | 0 | 3.39066E-06 | 1.09827E-05 | 3.20133E-05 |
S/L | 28997 | Fn3-99 | 56 | rs751293680 | 0.0836 | 0.172 | 0.027 | N | 0.335 | 0.158 | 0.480123561213 | gnomAD-2.1.1 | 8.05E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 1.78E-05 | 0 |
S/L | 28997 | Fn3-99 | 56 | rs751293680 | 0.0836 | 0.172 | 0.027 | N | 0.335 | 0.158 | 0.480123561213 | gnomAD-3.1.2 | 6.57E-06 | None | None | None | None | N | None | 2.41E-05 | 0 | 0 | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
S/L | 28997 | Fn3-99 | 56 | rs751293680 | 0.0836 | 0.172 | 0.027 | N | 0.335 | 0.158 | 0.480123561213 | gnomAD-4.0.0 | 3.84326E-06 | None | None | None | None | N | None | 1.6913E-05 | 0 | None | 0 | 0 | None | 0 | 0 | 4.78563E-06 | 0 | 0 |
R/G | 29194 | Fn3-100 | 58 | None | 0.7579 | None | 1.0 | N | 0.609 | 0.408 | 0.558264529485 | gnomAD-4.0.0 | 1.20032E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 6.07533E-05 | 0 |
R/S | 29194 | Fn3-100 | 58 | rs754456800 | 0.9318 | 0.114 | 1.0 | N | 0.689 | 0.358 | 0.310147130316 | gnomAD-2.1.1 | 4.02E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 8.87E-06 | 0 |
R/S | 29194 | Fn3-100 | 58 | rs754456800 | 0.9318 | 0.114 | 1.0 | N | 0.689 | 0.358 | 0.310147130316 | gnomAD-4.0.0 | 4.80129E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 5.25001E-06 | 0 | 0 |
R/T | 29194 | Fn3-100 | 58 | None | 0.9028 | None | 1.0 | N | 0.679 | 0.427 | 0.433491693731 | gnomAD-4.0.0 | 3.18207E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 5.71566E-06 | 0 | 0 |
T/I | 29294 | Fn3-101 | 58 | None | 0.4969 | None | 0.988 | N | 0.417 | 0.344 | 0.510172456258 | gnomAD-4.0.0 | 6.84156E-07 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 8.99418E-07 | 0 | 0 |
T/K | 29294 | Fn3-101 | 58 | None | 0.3429 | None | 0.92 | N | 0.41 | 0.337 | 0.442261297928 | gnomAD-4.0.0 | 6.84156E-07 | None | None | None | None | I | None | 0 | 0 | None | 3.82673E-05 | 0 | None | 0 | 0 | 0 | 0 | 0 |
E/K | 29392 | Fn3-102 | 58 | rs1553551691 | 0.2127 | None | 0.978 | N | 0.533 | 0.351 | 0.338834610459 | gnomAD-4.0.0 | 3.18261E-06 | None | None | None | None | I | None | 5.65291E-05 | 0 | None | 0 | 0 | None | 0 | 0 | 2.85799E-06 | 0 | 0 |
E/D | 29590 | Fn3-103 | 58 | rs879152203 | 0.0785 | -0.316 | 0.002 | N | 0.125 | 0.069 | 0.154104182512 | gnomAD-2.1.1 | 4.02E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 8.88E-06 | 0 |
E/D | 29590 | Fn3-103 | 58 | rs879152203 | 0.0785 | -0.316 | 0.002 | N | 0.125 | 0.069 | 0.154104182512 | gnomAD-3.1.2 | 6.57E-06 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 1.47E-05 | 0 | 0 |
E/D | 29590 | Fn3-103 | 58 | rs879152203 | 0.0785 | -0.316 | 0.002 | N | 0.125 | 0.069 | 0.154104182512 | gnomAD-4.0.0 | 1.05347E-05 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.44086E-05 | 0 | 0 |
E/Q | 29590 | Fn3-103 | 58 | rs72648236 | 0.1587 | -0.202 | 0.891 | N | 0.401 | 0.256 | 0.284150004643 | gnomAD-2.1.1 | 4.02E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 8.88E-06 | 0 |
E/Q | 29590 | Fn3-103 | 58 | rs72648236 | 0.1587 | -0.202 | 0.891 | N | 0.401 | 0.256 | 0.284150004643 | Begay (2015) | None | DCM | comp het with R14640C | None | None | N | WGS prioritisation; filtering with ANNOVAR; co-segregates within 2-generation family (n = 2, 2 affected (total 3)) | None | None | None | None | None | None | None | None | None | None | None |
E/Q | 29590 | Fn3-103 | 58 | rs72648236 | 0.1587 | -0.202 | 0.891 | N | 0.401 | 0.256 | 0.284150004643 | gnomAD-4.0.0 | 1.59104E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.85778E-06 | 0 | 0 |
D/N | 29690 | Fn3-104 | 58 | rs1209113873 | 0.5704 | -0.281 | 1.0 | N | 0.657 | 0.337 | 0.268660756437 | gnomAD-2.1.1 | 4.02E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 5.56E-05 | None | 0 | None | 0 | 0 | 0 |
D/N | 29690 | Fn3-104 | 58 | rs1209113873 | 0.5704 | -0.281 | 1.0 | N | 0.657 | 0.337 | 0.268660756437 | gnomAD-4.0.0 | 1.36843E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 5.03854E-05 | None | 0 | 0 | 0 | 0 | 0 |
T/I | 29792 | Fn3-105 | 59 | rs876658091 | 0.3599 | 0.096 | 0.999 | N | 0.723 | 0.381 | 0.421799068777 | gnomAD-2.1.1 | 1.07E-05 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 1.56E-05 | 1.40489E-04 |
T/I | 29792 | Fn3-105 | 59 | rs876658091 | 0.3599 | 0.096 | 0.999 | N | 0.723 | 0.381 | 0.421799068777 | gnomAD-3.1.2 | 3.29E-05 | None | None | None | None | N | None | 2.41E-05 | 0 | 0 | 0 | 0 | None | 0 | 0 | 5.88E-05 | 0 | 0 |
T/I | 29792 | Fn3-105 | 59 | rs876658091 | 0.3599 | 0.096 | 0.999 | N | 0.723 | 0.381 | 0.421799068777 | gnomAD-4.0.0 | 3.34628E-05 | None | None | None | None | N | None | 1.33472E-05 | 0 | None | 0 | 0 | None | 0 | 0 | 3.98364E-05 | 0 | 9.60615E-05 |
S/G | 29989 | Fn3-106 | 57 | rs1225946550 | 0.079 | None | None | N | 0.071 | 0.074 | None | gnomAD-3.1.2 | 1.97E-05 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 4.41E-05 | 0 | 0 |
S/G | 29989 | Fn3-106 | 57 | rs1225946550 | 0.079 | None | None | N | 0.071 | 0.074 | None | gnomAD-4.0.0 | 7.43666E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 9.32336E-06 | 0 | 1.60092E-05 |
S/T | 29989 | Fn3-106 | 57 | None | 0.0715 | None | 0.012 | N | 0.247 | 0.051 | 0.124217242631 | gnomAD-4.0.0 | 1.59153E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 1.88743E-05 | 0 | 0 | 0 | 0 |
G/A | 30381 | Fn3-109 | 58 | rs1411459280 | 0.1001 | 0.099 | 0.008 | N | 0.273 | 0.078 | 0.144782658237 | gnomAD-2.1.1 | 4.03E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 8.91E-06 | 0 |
G/A | 30381 | Fn3-109 | 58 | rs1411459280 | 0.1001 | 0.099 | 0.008 | N | 0.273 | 0.078 | 0.144782658237 | gnomAD-4.0.0 | 6.36462E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.14324E-05 | 0 | 0 |
G/E | 30381 | Fn3-109 | 58 | None | 0.2065 | None | 0.722 | N | 0.553 | 0.215 | 0.263612267334 | gnomAD-4.0.0 | 1.59116E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 1.43283E-05 | 0 |
G/R | 30381 | Fn3-109 | 58 | rs779339354 | 0.2278 | -0.304 | 0.901 | N | 0.621 | 0.211 | 0.389439708392 | gnomAD-2.1.1 | 4.03E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 5.57E-05 | None | 0 | None | 0 | 0 | 0 |
G/R | 30381 | Fn3-109 | 58 | rs779339354 | 0.2278 | -0.304 | 0.901 | N | 0.621 | 0.211 | 0.389439708392 | gnomAD-4.0.0 | 1.59116E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 2.77285E-05 | None | 0 | 0 | 0 | 0 | 0 |
E/D | 30478 | Fn3-110 | 57 | rs373900294 | 0.0865 | -0.411 | 0.016 | N | 0.227 | 0.032 | 0.141422826196 | gnomAD-2.1.1 | 2.51E-05 | None | None | None | None | I | None | 2.48283E-04 | 0 | None | 0 | 0 | None | 0 | None | 0 | 0 | 1.41004E-04 |
E/D | 30478 | Fn3-110 | 57 | rs373900294 | 0.0865 | -0.411 | 0.016 | N | 0.227 | 0.032 | 0.141422826196 | gnomAD-3.1.2 | 1.05168E-04 | None | None | None | None | I | None | 2.65508E-04 | 2.6202E-04 | 0 | 0 | 0 | None | 0 | 0 | 0 | 0 | 4.77555E-04 |
E/D | 30478 | Fn3-110 | 57 | rs373900294 | 0.0865 | -0.411 | 0.016 | N | 0.227 | 0.032 | 0.141422826196 | gnomAD-4.0.0 | 1.42561E-05 | None | None | None | None | I | None | 2.27018E-04 | 8.33806E-05 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 1.60133E-05 |
E/V | 30478 | Fn3-110 | 57 | rs794729531 | 0.2853 | 0.288 | 0.973 | N | 0.765 | 0.473 | 0.481246930725 | gnomAD-2.1.1 | 2.02E-05 | None | None | None | None | I | None | 0 | 1.45307E-04 | None | 0 | 0 | None | 0 | None | 0 | 0 | 0 |
E/V | 30478 | Fn3-110 | 57 | rs794729531 | 0.2853 | 0.288 | 0.973 | N | 0.765 | 0.473 | 0.481246930725 | gnomAD-3.1.2 | 1.31E-05 | None | None | None | None | I | None | 0 | 1.31079E-04 | 0 | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
E/V | 30478 | Fn3-110 | 57 | rs794729531 | 0.2853 | 0.288 | 0.973 | N | 0.765 | 0.473 | 0.481246930725 | gnomAD-4.0.0 | 1.02532E-05 | None | None | None | None | I | None | 0 | 1.35653E-04 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
A/G | 30676 | Fn3-111 | 58 | rs1237501659 | 0.1067 | -0.755 | 0.014 | N | 0.214 | 0.123 | 0.149567049428 | gnomAD-3.1.2 | 1.97E-05 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 4.41E-05 | 0 | 0 |
A/G | 30676 | Fn3-111 | 58 | rs1237501659 | 0.1067 | -0.755 | 0.014 | N | 0.214 | 0.123 | 0.149567049428 | gnomAD-4.0.0 | 6.40595E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 9.57268E-06 | 1.3403E-05 | 0 |
A/T | 30676 | Fn3-111 | 58 | None | 0.0728 | None | 0.698 | N | 0.485 | 0.174 | 0.170165803431 | gnomAD-4.0.0 | 2.40064E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.625E-06 | 0 | 0 |
E/A | 30777 | Fn3-112 | 59 | None | 0.5336 | None | 0.928 | N | 0.687 | 0.397 | 0.338834610459 | gnomAD-4.0.0 | 1.20032E-06 | None | None | None | None | N | None | 6.33473E-05 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
E/K | 30777 | Fn3-112 | 59 | None | 0.6616 | None | 0.928 | N | 0.559 | 0.306 | 0.306695030598 | gnomAD-4.0.0 | 1.20032E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.3125E-06 | 0 | 0 |
K/I | 30878 | Fn3-113 | 58 | rs1279509755 | 0.3484 | 0.654 | 0.642 | N | 0.422 | 0.242 | 0.386882687439 | gnomAD-2.1.1 | 4.02E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 0 | 1.65618E-04 |
R/C | 31072 | Fn3-114 | 57 | rs368932767 | 0.4655 | 0.019 | 1.0 | N | 0.639 | 0.422 | None | gnomAD-2.1.1 | 5.37E-05 | None | None | None | None | N | None | 4.14E-05 | 0 | None | 0 | 5.12E-05 | None | 0 | None | 7.99E-05 | 8.63E-05 | 0 |
R/C | 31072 | Fn3-114 | 57 | rs368932767 | 0.4655 | 0.019 | 1.0 | N | 0.639 | 0.422 | None | gnomAD-3.1.2 | 1.05184E-04 | None | None | None | None | N | None | 7.24E-05 | 6.55E-05 | 0 | 0 | 0 | None | 9.42E-05 | 0 | 1.61727E-04 | 0 | 0 |
R/C | 31072 | Fn3-114 | 57 | rs368932767 | 0.4655 | 0.019 | 1.0 | N | 0.639 | 0.422 | None | gnomAD-4.0.0 | 1.14644E-04 | None | None | None | None | N | None | 5.34017E-05 | 1.66711E-05 | None | 0 | 1.55971E-04 | None | 3.12529E-05 | 0 | 1.33921E-04 | 1.09796E-05 | 1.92111E-04 |
R/G | 31072 | Fn3-114 | 57 | rs368932767 | 0.6424 | -0.154 | 0.998 | N | 0.475 | 0.413 | 0.451882325854 | gnomAD-2.1.1 | 4.03E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 3.27E-05 | None | 0 | 0 | 0 |
R/G | 31072 | Fn3-114 | 57 | rs368932767 | 0.6424 | -0.154 | 0.998 | N | 0.475 | 0.413 | 0.451882325854 | gnomAD-4.0.0 | 2.05257E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 3.47802E-05 | 0 |
R/H | 31072 | Fn3-114 | 57 | rs141817409 | 0.2595 | -0.69 | 0.783 | N | 0.297 | 0.265 | None | gnomAD-2.1.1 | 1.14448E-04 | None | None | None | None | N | None | 9.51199E-04 | 1.97997E-04 | None | 0 | 0 | None | 0 | None | 4E-05 | 7.84E-06 | 0 |
R/H | 31072 | Fn3-114 | 57 | rs141817409 | 0.2595 | -0.69 | 0.783 | N | 0.297 | 0.265 | None | gnomAD-3.1.2 | 2.8928E-04 | None | None | None | None | N | None | 9.41256E-04 | 6.55E-05 | 0 | 0 | 1.93125E-04 | None | 9.43E-05 | 0 | 2.94E-05 | 0 | 0 |
R/H | 31072 | Fn3-114 | 57 | rs141817409 | 0.2595 | -0.69 | 0.783 | N | 0.297 | 0.265 | None | 1000 genomes | 7.98722E-04 | None | None | None | None | N | None | 3E-03 | 0 | None | None | 0 | 0 | None | None | None | 0 | None |
R/H | 31072 | Fn3-114 | 57 | rs141817409 | 0.2595 | -0.69 | 0.783 | N | 0.297 | 0.265 | None | gnomAD-4.0.0 | 7.74568E-05 | None | None | None | None | N | None | 1.07957E-03 | 1.83284E-04 | None | 0 | 6.68688E-05 | None | 1.56299E-05 | 0 | 2.11902E-05 | 0 | 6.40184E-05 |
Q/H | 31168 | Fn3-115 | 56 | None | 0.1412 | None | 0.912 | N | 0.305 | 0.124 | 0.214338557667 | gnomAD-4.0.0 | 1.59108E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 1.43271E-05 | 0 |
R/C | 31365 | Fn3-116 | 58 | rs372593328 | 0.3113 | -0.178 | 1.0 | N | 0.732 | 0.394 | None | gnomAD-2.1.1 | 2.15E-05 | None | None | None | None | N | None | 1.65426E-04 | 0 | None | 0 | 0 | None | 0 | None | 0 | 1.57E-05 | 0 |
R/C | 31365 | Fn3-116 | 58 | rs372593328 | 0.3113 | -0.178 | 1.0 | N | 0.732 | 0.394 | None | gnomAD-3.1.2 | 3.29E-05 | None | None | None | None | N | None | 9.66E-05 | 0 | 0 | 0 | 0 | None | 0 | 0 | 0 | 0 | 4.78011E-04 |
R/C | 31365 | Fn3-116 | 58 | rs372593328 | 0.3113 | -0.178 | 1.0 | N | 0.732 | 0.394 | None | gnomAD-4.0.0 | 1.23949E-05 | None | None | None | None | N | None | 8.01239E-05 | 1.6675E-05 | None | 0 | 2.23075E-05 | None | 0 | 0 | 8.47626E-06 | 0 | 3.20256E-05 |
R/H | 31365 | Fn3-116 | 58 | rs577262832 | 0.166 | -0.69 | 1.0 | N | 0.778 | 0.346 | 0.377451072189 | gnomAD-2.1.1 | 1.61E-05 | None | None | None | None | N | None | 0 | 0 | None | 0 | 5.59E-05 | None | 0 | None | 0 | 1.78E-05 | 1.66223E-04 |
R/H | 31365 | Fn3-116 | 58 | rs577262832 | 0.166 | -0.69 | 1.0 | N | 0.778 | 0.346 | 0.377451072189 | gnomAD-3.1.2 | 1.32E-05 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 2.94E-05 | 0 | 0 |
R/H | 31365 | Fn3-116 | 58 | rs577262832 | 0.166 | -0.69 | 1.0 | N | 0.778 | 0.346 | 0.377451072189 | gnomAD-4.0.0 | 3.40871E-05 | None | None | None | None | N | None | 1.33558E-05 | 0 | None | 0 | 4.4615E-05 | None | 0 | 3.28839E-04 | 3.89905E-05 | 3.29417E-05 | 1.60138E-05 |
R/L | 31365 | Fn3-116 | 58 | rs577262832 | 0.6048 | 0.618 | 1.0 | N | 0.594 | 0.361 | 0.391470661076 | gnomAD-2.1.1 | 4.03E-06 | None | None | None | None | N | None | 0 | 2.9E-05 | None | 0 | 0 | None | 0 | None | 0 | 0 | 0 |
R/L | 31365 | Fn3-116 | 58 | rs577262832 | 0.6048 | 0.618 | 1.0 | N | 0.594 | 0.361 | 0.391470661076 | gnomAD-4.0.0 | 1.36852E-06 | None | None | None | None | N | None | 0 | 2.23674E-05 | None | 0 | 0 | None | 0 | 0 | 8.99473E-07 | 0 | 0 |
E/K | 31465 | Fn3-117 | 58 | rs752194452 | 0.248 | 0.288 | 0.977 | N | 0.598 | 0.386 | 0.286848849266 | gnomAD-2.1.1 | 1.07E-05 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 2.34E-05 | 0 |
E/K | 31465 | Fn3-117 | 58 | rs752194452 | 0.248 | 0.288 | 0.977 | N | 0.598 | 0.386 | 0.286848849266 | gnomAD-3.1.2 | 3.94E-05 | None | None | None | None | I | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 8.82E-05 | 0 | 0 |
E/K | 31465 | Fn3-117 | 58 | rs752194452 | 0.248 | 0.288 | 0.977 | N | 0.598 | 0.386 | 0.286848849266 | gnomAD-4.0.0 | 5.57718E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 5.9333E-06 | 2.19563E-05 | 0 |
E/Q | 31465 | Fn3-117 | 58 | None | 0.1485 | None | 0.997 | N | 0.637 | 0.299 | 0.218112801441 | gnomAD-4.0.0 | 2.05261E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 2.51902E-05 | None | 1.87259E-05 | 0 | 8.99476E-07 | 0 | 0 |
D/E | 31566 | Fn3-118 | 61 | rs72648253 | 0.1162 | -0.069 | None | N | 0.091 | 0.117 | 0.104622674875 | gnomAD-2.1.1 | 3.62E-05 | None | None | None | None | I | None | 0 | 2.31924E-04 | None | 0 | 0 | None | 0 | None | 0 | 0 | 1.65782E-04 |
D/E | 31566 | Fn3-118 | 61 | rs72648253 | 0.1162 | -0.069 | None | N | 0.091 | 0.117 | 0.104622674875 | gnomAD-4.0.0 | 1.27301E-05 | None | None | None | None | I | None | 0 | 1.82916E-04 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
D/H | 31566 | Fn3-118 | 61 | rs1697332587 | 0.5654 | None | 0.773 | D | 0.467 | 0.402 | 0.263612267334 | gnomAD-4.0.0 | 2.73684E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.69845E-06 | 0 | 1.65662E-05 |
D/N | 31566 | Fn3-118 | 61 | None | 0.1614 | None | 0.324 | N | 0.437 | 0.258 | 0.178374595973 | gnomAD-4.0.0 | 1.36842E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 8.99484E-07 | 0 | 1.65662E-05 |
T/N | 31764 | Fn3-119 | 57 | rs1357116939 | 0.1058 | None | 0.997 | N | 0.497 | 0.361 | 0.370789594751 | gnomAD-4.0.0 | 1.20032E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 2.75482E-04 | None | 0 | 0 | 0 | 0 | 0 |
T/S | 31764 | Fn3-119 | 57 | rs1175551497 | 0.0846 | -0.764 | 0.775 | N | 0.273 | 0.18 | 0.158396225186 | gnomAD-2.1.1 | 4.02E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 5.57E-05 | None | 0 | None | 0 | 0 | 0 |
T/S | 31764 | Fn3-119 | 57 | rs1175551497 | 0.0846 | -0.764 | 0.775 | N | 0.273 | 0.18 | 0.158396225186 | gnomAD-4.0.0 | 1.36838E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 5.03931E-05 | None | 0 | 0 | 0 | 0 | 0 |
D/A | 31865 | Fn3-120 | 59 | None | 0.7246 | None | 1.0 | N | 0.753 | 0.487 | 0.499473279415 | gnomAD-4.0.0 | 1.59155E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 1.43283E-05 | 0 |
D/E | 31865 | Fn3-120 | 59 | rs745843064 | 0.4963 | -0.148 | 1.0 | N | 0.41 | 0.25 | 0.197625483188 | gnomAD-2.1.1 | 4.02E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 5.56E-05 | None | 0 | None | 0 | 0 | 0 |
D/H | 31865 | Fn3-120 | 59 | rs1696661402 | 0.8546 | None | 1.0 | N | 0.732 | 0.475 | 0.35139820857 | gnomAD-3.1.2 | 6.57E-06 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 0 | 2.07383E-04 | 0 |
D/H | 31865 | Fn3-120 | 59 | rs1696661402 | 0.8546 | None | 1.0 | N | 0.732 | 0.475 | 0.35139820857 | gnomAD-4.0.0 | 3.84385E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.3936E-06 | 2.68046E-05 | 0 |
K/T | 32161 | Fn3-122 | 57 | None | 0.685 | None | 1.0 | N | 0.653 | 0.466 | 0.369682402691 | gnomAD-4.0.0 | 1.20032E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.3125E-06 | 0 | 0 |
R/G | 32456 | Fn3-124 | 58 | None | 0.6508 | None | 1.0 | N | 0.645 | 0.286 | 0.470484629704 | gnomAD-4.0.0 | 7.52681E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 9.89463E-06 | 0 | 0 |
R/K | 32456 | Fn3-124 | 58 | rs879169496 | 0.3012 | None | 0.997 | N | 0.523 | 0.346 | None | gnomAD-4.0.0 | 1.20032E-06 | None | None | None | None | N | None | 6.33473E-05 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 0 | 0 |
R/S | 32456 | Fn3-124 | 58 | rs771232040 | 0.8507 | -0.118 | 1.0 | N | 0.723 | 0.372 | 0.242825505644 | gnomAD-2.1.1 | 4.02E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 3.27E-05 | None | 0 | 0 | 0 |
R/S | 32456 | Fn3-124 | 58 | rs771232040 | 0.8507 | -0.118 | 1.0 | N | 0.723 | 0.372 | 0.242825505644 | gnomAD-4.0.0 | 1.36852E-06 | None | None | None | None | N | None | 2.98846E-05 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 1.15934E-05 | 0 |
M/I | 32556 | Fn3-125 | 58 | None | 0.7223 | None | 0.985 | N | 0.487 | 0.321 | 0.683392867763 | gnomAD-4.0.0 | 1.20033E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.31251E-06 | 0 | 0 |
M/T | 32556 | Fn3-125 | 58 | rs1257976666 | 0.3555 | -0.863 | 0.994 | N | 0.526 | 0.49 | 0.7584815763 | gnomAD-2.1.1 | 4.03E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 3.29E-05 | None | 0 | 0 | 0 |
M/T | 32556 | Fn3-125 | 58 | rs1257976666 | 0.3555 | -0.863 | 0.994 | N | 0.526 | 0.49 | 0.7584815763 | gnomAD-4.0.0 | 1.59281E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 0 | 1.4362E-05 | 0 |
I/M | 32657 | Fn3-126 | 58 | rs761994900 | 0.1361 | None | 0.817 | N | 0.315 | 0.094 | 0.355034743287 | gnomAD-4.0.0 | 2.73675E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 3.59786E-06 | 0 | 0 |
I/N | 32657 | Fn3-126 | 58 | None | 0.5046 | None | 0.999 | N | 0.679 | 0.44 | 0.81315104837 | gnomAD-4.0.0 | 1.59115E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.85822E-06 | 0 | 0 |
G/S | 32852 | Fn3-127 | 58 | None | 0.1383 | None | 0.001 | N | 0.221 | 0.187 | 0.128392430309 | gnomAD-4.0.0 | 1.59117E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 2.85825E-06 | 0 | 0 |
G/V | 32852 | Fn3-127 | 58 | rs1693340480 | 0.3582 | None | 0.627 | N | 0.482 | 0.306 | 0.628842659243 | gnomAD-4.0.0 | 1.59121E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 2.77254E-05 | None | 0 | 0 | 0 | 0 | 0 |
T/I | 32954 | Fn3-128 | 59 | rs372126622 | 0.7877 | 0.08 | 1.0 | N | 0.693 | 0.432 | None | gnomAD-2.1.1 | 4.02E-05 | None | None | None | None | N | None | 1.93523E-04 | 1.15949E-04 | None | 0 | 0 | None | 3.27E-05 | None | 0 | 1.78E-05 | 0 |
T/I | 32954 | Fn3-128 | 59 | rs372126622 | 0.7877 | 0.08 | 1.0 | N | 0.693 | 0.432 | None | gnomAD-3.1.2 | 1.97E-05 | None | None | None | None | N | None | 2.41E-05 | 0 | 0 | 0 | 0 | None | 0 | 0 | 2.94E-05 | 0 | 0 |
T/I | 32954 | Fn3-128 | 59 | rs372126622 | 0.7877 | 0.08 | 1.0 | N | 0.693 | 0.432 | None | gnomAD-4.0.0 | 4.02813E-05 | None | None | None | None | N | None | 2.6703E-05 | 6.66933E-05 | None | 0 | 0 | None | 0 | 0 | 4.83153E-05 | 2.19578E-05 | 0 |
V/A | 33348 | Fn3-130 | 59 | rs957996377 | 0.1451 | None | 0.139 | N | 0.128 | 0.172 | 0.417460480802 | gnomAD-3.1.2 | 6.57E-06 | None | None | None | None | I | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 1.47E-05 | 0 | 0 |
V/A | 33348 | Fn3-130 | 59 | rs957996377 | 0.1451 | None | 0.139 | N | 0.128 | 0.172 | 0.417460480802 | gnomAD-4.0.0 | 3.84645E-06 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 7.1836E-06 | 0 | 0 |
V/M | 33348 | Fn3-130 | 59 | rs757184326 | 0.2001 | -0.311 | 0.975 | N | 0.354 | 0.221 | 0.457741393631 | gnomAD-2.1.1 | 1.62E-05 | None | None | None | None | I | None | 0 | 0 | None | 0 | 0 | None | 1.31527E-04 | None | 0 | 0 | 0 |
V/M | 33348 | Fn3-130 | 59 | rs757184326 | 0.2001 | -0.311 | 0.975 | N | 0.354 | 0.221 | 0.457741393631 | gnomAD-4.0.0 | 9.58358E-06 | None | None | None | None | I | None | 0 | 2.24165E-05 | None | 0 | 0 | None | 0 | 0 | 0 | 1.50949E-04 | 0 |
E/A | 33449 | Fn3-131 | 58 | rs1218969890 | 0.373 | -1.049 | 0.992 | N | 0.571 | 0.482 | 0.422524665647 | gnomAD-2.1.1 | 3.18E-05 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | None | 0 | 6.48E-05 | 0 |
E/A | 33449 | Fn3-131 | 58 | rs1218969890 | 0.373 | -1.049 | 0.992 | N | 0.571 | 0.482 | 0.422524665647 | gnomAD-3.1.2 | 6.57E-06 | None | None | None | None | N | None | 0 | 0 | 0 | 0 | 0 | None | 0 | 0 | 1.47E-05 | 0 | 0 |
E/A | 33449 | Fn3-131 | 58 | rs1218969890 | 0.373 | -1.049 | 0.992 | N | 0.571 | 0.482 | 0.422524665647 | gnomAD-4.0.0 | 3.71835E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 4.23816E-06 | 0 | 1.60118E-05 |
E/Q | 33449 | Fn3-131 | 58 | None | 0.3129 | None | 0.916 | N | 0.363 | 0.105 | 0.229264304666 | gnomAD-4.0.0 | 1.20032E-06 | None | None | None | None | N | None | 0 | 0 | None | 0 | 0 | None | 0 | 0 | 1.3125E-06 | 0 | 0 |
Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.