Structural position:

  • Domain Type: Fn3
  • Aligned Position: 90
  • Secondary Structure Element: e
  • Secondary Structure Region: β-strand E

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
E/D 15715 Fn3-1 59 rs553017488 0.2806 -0.459 0.004 D 0.308 0.103 0.304108284078 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.93E-06 0
E/D 15715 Fn3-1 59 rs553017488 0.2806 -0.459 0.004 D 0.308 0.103 0.304108284078 gnomAD-4.0.0 1.77998E-05 None None None None N None 2.99312E-05 0 None 0 0 None 0 0 2.24969E-05 0 0
E/K 15715 Fn3-1 59 rs764958886 0.3032 0.451 0.581 N 0.597 0.301 0.307648195649 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
E/K 15715 Fn3-1 59 rs764958886 0.3032 0.451 0.581 N 0.597 0.301 0.307648195649 gnomAD-3.1.2 6.59E-06 None None None None N None 0 6.57E-05 0 0 0 None 0 0 0 0 0
E/K 15715 Fn3-1 59 rs764958886 0.3032 0.451 0.581 N 0.597 0.301 0.307648195649 gnomAD-4.0.0 2.48057E-06 None None None None N None 0 1.6699E-05 None 0 0 None 0 3.29381E-04 8.48077E-07 0 0
E/Q 15715 Fn3-1 59 rs764958886 0.1818 -0.167 0.83 N 0.706 0.209 0.330331372229 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.92E-06 0
E/Q 15715 Fn3-1 59 rs764958886 0.1818 -0.167 0.83 N 0.706 0.209 0.330331372229 gnomAD-4.0.0 2.0538E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69963E-06 0 0
S/C 15817 Fn3-2 60 None 0.114 None 0.999 D 0.661 0.388 0.429780353351 gnomAD-4.0.0 1.59341E-06 None None None None N None 0 0 None 0 0 None 1.88239E-05 0 0 0 0
T/P 15918 Fn3-3 60 None 0.5089 None 0.996 D 0.515 0.359 0.475895305069 gnomAD-4.0.0 7.02917E-07 None None None None N None 0 0 None 0 0 None 0 0 9.12137E-07 0 0
E/D 16113 Fn3-4 59 None 0.2528 None 0.999 N 0.471 0.27 0.187945064343 gnomAD-4.0.0 1.59558E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43542E-05 0
E/K 16113 Fn3-4 59 rs548275593 0.2467 -0.524 0.999 N 0.591 0.402 0.352693368174 gnomAD-2.1.1 6.86E-05 None None None None I None 0 0 None 0 0 None 5.57304E-04 None 0 0 0
E/K 16113 Fn3-4 59 rs548275593 0.2467 -0.524 0.999 N 0.591 0.402 0.352693368174 gnomAD-3.1.2 2.63E-05 None None None None I None 0 0 0 0 0 None 0 0 0 8.285E-04 0
E/K 16113 Fn3-4 59 rs548275593 0.2467 -0.524 0.999 N 0.591 0.402 0.352693368174 gnomAD-4.0.0 3.72259E-05 None None None None I None 0 0 None 0 0 None 0 0 0 6.48808E-04 1.60333E-05
N/D 16409 Fn3-6 59 rs1315841408 0.174 -0.315 0.024 N 0.315 0.124 0.18995819373 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 0 9.19118E-04
N/D 16409 Fn3-6 59 rs1315841408 0.174 -0.315 0.024 N 0.315 0.124 0.18995819373 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/D 16409 Fn3-6 59 rs1315841408 0.174 -0.315 0.024 N 0.315 0.124 0.18995819373 gnomAD-4.0.0 2.5665E-06 None None None None N None 0 0 None 0 0 None 0 0 4.79237E-06 0 0
N/I 16409 Fn3-6 59 rs2056864818 0.1244 None 0.055 N 0.49 0.132 0.364926071151 gnomAD-4.0.0 1.59385E-06 None None None None N None 0 0 None 0 2.79423E-05 None 0 0 0 0 0
N/K 16409 Fn3-6 59 rs2056864466 0.1397 None None N 0.132 0.116 0.0297737177859 gnomAD-4.0.0 1.59385E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86175E-06 0 0
T/S 16509 Fn3-7 60 rs779933778 0.1498 -0.92 0.826 N 0.401 0.169 0.202086224978 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
T/S 16509 Fn3-7 60 rs779933778 0.1498 -0.92 0.826 N 0.401 0.169 0.202086224978 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94553E-04 None 0 0 0 0 0
T/S 16509 Fn3-7 60 rs779933778 0.1498 -0.92 0.826 N 0.401 0.169 0.202086224978 gnomAD-4.0.0 6.57999E-06 None None None None N None 0 0 None 0 1.94553E-04 None 0 0 0 0 0
K/N 16709 Fn3-9 59 rs1244376906 0.887 -0.138 0.999 N 0.701 0.241 0.165133752707 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.49E-05 0
K/N 16709 Fn3-9 59 rs1244376906 0.887 -0.138 0.999 N 0.701 0.241 0.165133752707 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/N 16709 Fn3-9 59 rs1244376906 0.887 -0.138 0.999 N 0.701 0.241 0.165133752707 gnomAD-4.0.0 6.58328E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47223E-05 0 0
K/Q 16709 Fn3-9 59 rs755961446 0.4228 -0.037 0.999 N 0.697 0.355 0.165133752707 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 9.81E-05 None 0 0 0
K/Q 16709 Fn3-9 59 rs755961446 0.4228 -0.037 0.999 N 0.697 0.355 0.165133752707 gnomAD-4.0.0 7.96952E-06 None None None None N None 0 0 None 0 0 None 0 0 0 7.1662E-05 0
K/R 16709 Fn3-9 59 rs2056499137 0.1137 None 0.998 N 0.591 0.191 0.194818534648 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.41E-05 0 0 0 0
K/R 16709 Fn3-9 59 rs2056499137 0.1137 None 0.998 N 0.591 0.191 0.194818534648 gnomAD-4.0.0 2.56639E-06 None None None None N None 0 0 None 0 0 None 1.5704E-05 0 0 0 2.8516E-05
K/R 16911 Fn3-11 60 None 0.083 None 0.999 N 0.561 0.291 0.380052290102 gnomAD-4.0.0 1.59291E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86143E-06 0 0
T/N 17206 Fn3-13 60 rs1305177155 0.1902 -0.342 0.684 N 0.423 0.271 0.222439326576 gnomAD-2.1.1 2.01E-05 None None None None N None 0 1.44827E-04 None 0 0 None 0 None 0 0 0
T/N 17206 Fn3-13 60 rs1305177155 0.1902 -0.342 0.684 N 0.423 0.271 0.222439326576 gnomAD-3.1.2 6.59E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/N 17206 Fn3-13 60 rs1305177155 0.1902 -0.342 0.684 N 0.423 0.271 0.222439326576 gnomAD-4.0.0 7.44109E-06 None None None None N None 0 1.0014E-04 None 0 0 None 0 0 4.24013E-06 0 1.60241E-05
Q/R 17628 Fn3-16 60 rs1326205439 0.0896 None 0.007 N 0.315 0.104 0.110078149338 gnomAD-4.0.0 1.59267E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86112E-06 0 0
E/V 18230 Fn3-20 65 None 0.4315 None 0.999 N 0.849 0.473 0.500176316166 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.9375E-06 0 0
E/D 18333 Fn3-21 62 rs764950995 0.1375 -0.988 0.961 N 0.413 0.202 0.266843984389 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
E/D 18333 Fn3-21 62 rs764950995 0.1375 -0.988 0.961 N 0.413 0.202 0.266843984389 gnomAD-3.1.2 4.61E-05 None None None None N None 2.42E-05 0 0 0 0 None 0 0 8.83E-05 0 0
E/D 18333 Fn3-21 62 rs764950995 0.1375 -0.988 0.961 N 0.413 0.202 0.266843984389 gnomAD-4.0.0 6.13903E-05 None None None None N None 1.3364E-05 0 None 0 0 None 0 0 8.31051E-05 0 0
T/A 18537 Fn3-22 59 None 0.0732 None None N 0.139 0.162 0.0551355673512 gnomAD-4.0.0 1.5935E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86166E-06 0 0
T/I 18537 Fn3-22 59 rs1027035888 0.2051 -0.189 0.055 N 0.369 0.21 0.288727942641 gnomAD-2.1.1 4.03E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
T/I 18537 Fn3-22 59 rs1027035888 0.2051 -0.189 0.055 N 0.369 0.21 0.288727942641 gnomAD-4.0.0 1.59355E-06 None None None None N None 5.67022E-05 0 None 0 0 None 0 0 0 0 0
T/K 18843 Fn3-24 60 None 0.1285 -0.13 0.03 N 0.351 0.137 0.0401082797425 gnomAD-2.1.1 9.02E-06 None None None None N None 6.65E-05 0 None 0 0 None 0 None 0 9.63E-06 0
T/K 18843 Fn3-24 60 None 0.1285 -0.13 0.03 N 0.351 0.137 0.0401082797425 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
T/K 18843 Fn3-24 60 None 0.1285 -0.13 0.03 N 0.351 0.137 0.0401082797425 gnomAD-4.0.0 2.52535E-06 None None None None N None 2.72926E-05 0 None 0 0 None 0 0 8.54756E-07 1.18686E-05 0
T/M 18843 Fn3-24 60 rs755999830 0.0712 -0.072 0.002 N 0.223 0.147 0.0986583533028 gnomAD-2.1.1 2.25E-05 None None None None N None 0 3.52E-05 None 0 0 None 8.18E-05 None 0 1.93E-05 0
T/M 18843 Fn3-24 60 rs755999830 0.0712 -0.072 0.002 N 0.223 0.147 0.0986583533028 gnomAD-4.0.0 9.07816E-06 None None None None N None 0 2.6388E-05 None 0 0 None 0 0 8.16725E-06 3.77663E-05 0
T/R 18843 Fn3-24 60 rs755999830 0.1038 -0.063 0.13 N 0.404 0.132 0.0920862733494 gnomAD-2.1.1 4.51E-06 None None None None N None 0 0 None 0 0 None 0 None 0 9.63E-06 0
T/R 18843 Fn3-24 60 rs755999830 0.1038 -0.063 0.13 N 0.404 0.132 0.0920862733494 gnomAD-4.0.0 1.39664E-06 None None None None N None 0 0 None 0 0 None 0 0 1.81494E-06 0 0
S/A 18947 Fn3-25 64 rs1357569723 0.1942 -0.932 0.625 N 0.558 0.2 0.19670166235 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
K/N 19047 Fn3-26 60 rs758155786 0.7575 -0.529 1.0 N 0.746 0.304 0.141422826196 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.57E-05 None 0 None 0 0 0
K/N 19047 Fn3-26 60 rs758155786 0.7575 -0.529 1.0 N 0.746 0.304 0.141422826196 gnomAD-4.0.0 1.59283E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86036E-06 0 0
N/K 19242 Fn3-27 60 rs1201568754 0.6357 None 0.201 N 0.459 0.124 0.110078149338 gnomAD-4.0.0 6.88921E-07 None None None None N None 0 0 None 0 0 None 0 0 9.0352E-07 0 0
T/A 19538 Fn3-29 60 rs200017524 0.0996 -0.811 0.9 N 0.46 0.249 None gnomAD-2.1.1 4.54308E-04 None None None None N None 4.46465E-03 3.4029E-04 None 0 0 None 0 None 0 4.7E-05 1.40687E-04
T/A 19538 Fn3-29 60 rs200017524 0.0996 -0.811 0.9 N 0.46 0.249 None gnomAD-3.1.2 1.40725E-03 None None None None N None 4.63499E-03 6.55136E-04 0 0 0 None 0 0 5.88E-05 0 3.83142E-03
T/A 19538 Fn3-29 60 rs200017524 0.0996 -0.811 0.9 N 0.46 0.249 None 1000 genomes 1.19808E-03 None None None None N None 4.5E-03 0 None None 0 0 None None None 0 None
T/A 19538 Fn3-29 60 rs200017524 0.0996 -0.811 0.9 N 0.46 0.249 None gnomAD-4.0.0 2.61564E-04 None None None None N None 4.69296E-03 4.16945E-04 None 6.7595E-05 0 None 0 1.6518E-04 1.52593E-05 0 3.84234E-04
T/I 19538 Fn3-29 60 rs370686112 0.1994 None 0.997 N 0.722 0.433 0.565649094883 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 9.43E-05 0 0 0 0
T/I 19538 Fn3-29 60 rs370686112 0.1994 None 0.997 N 0.722 0.433 0.565649094883 gnomAD-4.0.0 6.57877E-06 None None None None N None 0 0 None 0 0 None 9.42507E-05 0 0 0 0
T/K 19538 Fn3-29 60 rs370686112 0.263 -0.374 0.994 N 0.691 0.368 None gnomAD-2.1.1 3.22E-05 None None None None N None 3.72055E-04 0 None 0 0 None 0 None 0 0 0
T/K 19538 Fn3-29 60 rs370686112 0.263 -0.374 0.994 N 0.691 0.368 None gnomAD-3.1.2 1.0526E-04 None None None None N None 3.86436E-04 0 0 0 0 None 0 0 0 0 0
T/K 19538 Fn3-29 60 rs370686112 0.263 -0.374 0.994 N 0.691 0.368 None gnomAD-4.0.0 2.54157E-05 None None None None N None 5.47689E-04 0 None 0 0 None 0 0 0 0 0
K/I 19638 Fn3-30 60 rs1257692385 0.3979 0.765 0.966 N 0.636 0.476 0.675970969783 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
K/I 19638 Fn3-30 60 rs1257692385 0.3979 0.765 0.966 N 0.636 0.476 0.675970969783 gnomAD-4.0.0 1.59197E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43312E-05 0
K/E 19741 Fn3-31 62 rs1283284446 0.2137 None 0.012 N 0.446 0.147 0.178374595973 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/E 19741 Fn3-31 62 rs1283284446 0.2137 None 0.012 N 0.446 0.147 0.178374595973 gnomAD-4.0.0 6.5773E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47106E-05 0 0
K/T 19741 Fn3-31 62 rs1443597990 0.1239 None None N 0.321 0.203 0.156986980423 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94326E-04 None 0 0 0 0 0
K/T 19741 Fn3-31 62 rs1443597990 0.1239 None None N 0.321 0.203 0.156986980423 gnomAD-4.0.0 2.03017E-06 None None None None N None 0 0 None 0 1.13947E-04 None 0 0 0 0 3.40275E-05
S/G 19935 Fn3-32 59 rs377276874 0.2396 None 0.999 N 0.535 0.414 0.313518423057 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
S/G 19935 Fn3-32 59 rs377276874 0.2396 None 0.999 N 0.535 0.414 0.313518423057 gnomAD-4.0.0 1.31565E-05 None None None None N None 0 0 None 0 0 None 0 0 2.9423E-05 0 0
S/N 19935 Fn3-32 59 None 0.3644 None 0.999 N 0.631 0.295 0.275641507738 gnomAD-4.0.0 2.05355E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69893E-06 0 0
S/R 19935 Fn3-32 59 None 0.9133 -0.214 1.0 N 0.747 0.534 0.285316908763 gnomAD-2.1.1 4.04E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
S/R 19935 Fn3-32 59 None 0.9133 -0.214 1.0 N 0.747 0.534 0.285316908763 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/R 19935 Fn3-32 59 None 0.9133 -0.214 1.0 N 0.747 0.534 0.285316908763 gnomAD-4.0.0 3.0453E-06 None None None None N None 5.24366E-05 0 None 0 0 None 0 0 0 0 0
E/D 20034 Fn3-33 58 None 0.1312 None None N 0.201 0.058 0.117506650769 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 1.94099E-04 0 None 0 0 1.3125E-06 0 0
E/G 20034 Fn3-33 58 None 0.1899 None 0.124 N 0.555 0.112 0.223146558224 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
E/Q 20034 Fn3-33 58 rs746056036 0.1119 -0.624 0.497 N 0.566 0.159 0.234412748748 gnomAD-2.1.1 3.22E-05 None None None None N None 0 0 None 0 4.47377E-04 None 0 None 0 0 0
E/Q 20034 Fn3-33 58 rs746056036 0.1119 -0.624 0.497 N 0.566 0.159 0.234412748748 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94553E-04 None 0 0 0 0 0
E/Q 20034 Fn3-33 58 rs746056036 0.1119 -0.624 0.497 N 0.566 0.159 0.234412748748 gnomAD-4.0.0 5.57843E-06 None None None None N None 0 0 None 0 2.01117E-04 None 0 0 0 0 0
K/N 20329 Fn3-35 59 None 0.4755 None 0.722 N 0.577 0.175 0.199424873507 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
A/V 20431 Fn3-36 61 rs2049959864 0.2249 None 1.0 N 0.585 0.406 0.606927088724 gnomAD-4.0.0 1.59432E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43815E-05 0
R/C 21022 Fn3-40 60 rs779112015 0.5268 -0.466 1.0 N 0.777 0.417 0.449860987313 gnomAD-2.1.1 4.05E-05 None None None None N None 0 2.93E-05 None 0 0 None 2.6476E-04 None 0 0 1.67729E-04
R/C 21022 Fn3-40 60 rs779112015 0.5268 -0.466 1.0 N 0.777 0.417 0.449860987313 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
R/C 21022 Fn3-40 60 rs779112015 0.5268 -0.466 1.0 N 0.777 0.417 0.449860987313 gnomAD-4.0.0 1.98558E-05 None None None None N None 0 1.67532E-05 None 0 2.23334E-05 None 0 0 6.78525E-06 1.98605E-04 6.41416E-05
R/H 21022 Fn3-40 60 rs727503585 0.3054 -0.961 1.0 N 0.769 0.4 0.380394304726 gnomAD-2.1.1 1.22393E-04 None None None None N None 0 7.72798E-04 None 0 2.58078E-04 None 3.33E-05 None 0 7.86E-06 0
R/H 21022 Fn3-40 60 rs727503585 0.3054 -0.961 1.0 N 0.769 0.4 0.380394304726 gnomAD-3.1.2 6.58E-05 None None None None N None 4.83E-05 3.27869E-04 0 0 3.88651E-04 None 0 0 1.47E-05 0 0
R/H 21022 Fn3-40 60 rs727503585 0.3054 -0.961 1.0 N 0.769 0.4 0.380394304726 gnomAD-4.0.0 3.59993E-05 None None None None N None 5.35246E-05 5.19855E-04 None 0 8.93136E-05 None 0 0 1.27243E-05 3.31558E-05 1.604E-05
R/L 21022 Fn3-40 60 rs727503585 0.7614 None 1.0 N 0.659 0.401 0.413503789086 gnomAD-4.0.0 2.74134E-06 None None None None N None 0 0 None 0 0 None 0 0 3.60079E-06 0 0
E/K 21129 Fn3-41 66 rs2049409124 0.3861 None 0.885 N 0.449 0.242 0.273938319068 gnomAD-4.0.0 1.59314E-06 None None None None I None 0 0 None 0 0 None 0 0 2.86118E-06 0 0
S/G 21324 Fn3-42 59 None 0.1203 None 0.999 N 0.549 0.41 0.369495900351 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/R 21324 Fn3-42 59 None 0.7753 None 1.0 N 0.776 0.463 0.419713421852 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
S/N 22014 Fn3-47 59 rs750531050 0.1962 -0.242 0.684 N 0.403 0.204 0.277317399466 gnomAD-2.1.1 8.07E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
S/N 22014 Fn3-47 59 rs750531050 0.1962 -0.242 0.684 N 0.403 0.204 0.277317399466 gnomAD-4.0.0 2.05368E-06 None None None None N None 0 0 None 0 0 None 0 0 0 3.47979E-05 0
S/R 22014 Fn3-47 59 None 0.6758 None 0.007 N 0.306 0.267 0.295974979623 gnomAD-4.0.0 1.20039E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31258E-06 0 0
S/T 22014 Fn3-47 59 rs750531050 0.0785 -0.125 0.684 N 0.411 0.199 0.281780670237 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
S/T 22014 Fn3-47 59 rs750531050 0.0785 -0.125 0.684 N 0.411 0.199 0.281780670237 gnomAD-4.0.0 3.42281E-06 None None None None N None 5.98372E-05 2.23814E-05 None 0 0 None 0 0 1.79952E-06 0 0
T/I 22114 Fn3-48 60 rs1575927090 0.4735 None 0.994 N 0.789 0.348 0.452928561435 gnomAD-4.0.0 4.77649E-06 None None None None N None 0 0 None 0 8.32408E-05 None 0 0 0 0 0
R/C 22216 Fn3-49 61 rs1365775589 0.1752 -0.645 0.999 N 0.473 0.268 0.60829468558 gnomAD-2.1.1 1.21E-05 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 8.91E-06 0
R/C 22216 Fn3-49 61 rs1365775589 0.1752 -0.645 0.999 N 0.473 0.268 0.60829468558 gnomAD-4.0.0 8.90043E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29913E-06 6.95894E-05 0
R/H 22216 Fn3-49 61 None 0.0883 -1.062 0.031 N 0.247 0.155 None gnomAD-2.1.1 2.82E-05 None None None None I None 1.29349E-04 0 None 0 5.64E-05 None 0 None 0 3.56E-05 0
R/H 22216 Fn3-49 61 None 0.0883 -1.062 0.031 N 0.247 0.155 None gnomAD-3.1.2 3.29E-05 None None None None I None 4.83E-05 1.31182E-04 0 0 0 None 0 0 1.47E-05 0 0
R/H 22216 Fn3-49 61 None 0.0883 -1.062 0.031 N 0.247 0.155 None gnomAD-4.0.0 4.46481E-05 None None None None I None 9.35329E-05 3.33778E-05 None 0 4.47928E-05 None 0 0 4.91851E-05 0 4.80893E-05
R/L 22216 Fn3-49 61 rs753717922 0.2965 None 0.653 N 0.414 0.225 0.441017621159 gnomAD-4.0.0 2.7386E-06 None None None None I None 0 0 None 0 0 None 0 0 3.59952E-06 0 0
R/P 22216 Fn3-49 61 rs753717922 0.9557 -0.088 0.902 N 0.506 0.291 0.364141725642 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.91E-06 0
R/P 22216 Fn3-49 61 rs753717922 0.9557 -0.088 0.902 N 0.506 0.291 0.364141725642 gnomAD-4.0.0 6.8465E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99881E-07 0 0
Q/H 22507 Fn3-51 57 None 0.1373 None None N 0.201 0.132 0.176091768786 gnomAD-4.0.0 1.5922E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86015E-06 0 0
T/A 22702 Fn3-52 60 None 0.0826 None None N 0.193 0.079 0.137902524267 gnomAD-4.0.0 1.59221E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86026E-06 0 0
T/I 22702 Fn3-52 60 rs1404079334 0.1819 0.387 0.317 N 0.509 0.145 0.223847106136 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
T/I 22702 Fn3-52 60 rs1404079334 0.1819 0.387 0.317 N 0.509 0.145 0.223847106136 gnomAD-4.0.0 1.59223E-06 None None None None N None 0 2.28739E-05 None 0 0 None 0 0 0 0 0
T/P 22702 Fn3-52 60 rs574172442 0.6763 -0.248 0.317 N 0.507 0.305 0.211220785272 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 1.30736E-04 None 0 0 0
T/P 22702 Fn3-52 60 rs574172442 0.6763 -0.248 0.317 N 0.507 0.305 0.211220785272 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07641E-04 0
T/P 22702 Fn3-52 60 rs574172442 0.6763 -0.248 0.317 N 0.507 0.305 0.211220785272 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
T/P 22702 Fn3-52 60 rs574172442 0.6763 -0.248 0.317 N 0.507 0.305 0.211220785272 gnomAD-4.0.0 1.02542E-05 None None None None N None 0 0 None 0 0 None 0 0 0 1.07239E-04 0
A/D 22900 Fn3-54 60 rs780862555 0.5316 -1.256 0.998 N 0.764 0.369 0.515149029962 gnomAD-2.1.1 1.79E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.93E-05 0
A/D 22900 Fn3-54 60 rs780862555 0.5316 -1.256 0.998 N 0.764 0.369 0.515149029962 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/D 22900 Fn3-54 60 rs780862555 0.5316 -1.256 0.998 N 0.764 0.369 0.515149029962 gnomAD-4.0.0 1.23975E-05 None None None None N None 0 0 None 0 0 None 0 0 1.69553E-05 0 0
A/G 22900 Fn3-54 60 None 0.207 None 0.979 N 0.508 0.295 0.369495900351 gnomAD-4.0.0 2.73754E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69885E-06 0 1.65717E-05
A/P 22900 Fn3-54 60 None 0.8002 None 0.998 N 0.78 0.445 0.486135451721 gnomAD-4.0.0 6.84367E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15969E-05 0
A/T 22900 Fn3-54 60 rs2046756286 0.1049 None 0.958 N 0.582 0.257 0.366848117066 gnomAD-4.0.0 1.43717E-05 None None None None N None 0 0 None 0 0 None 0 0 1.88917E-05 0 0
R/K 23098 Fn3-55 59 rs771768640 0.1142 -0.125 0.987 N 0.56 0.297 0.223146558224 gnomAD-2.1.1 1.07E-05 None None None None N None 8.27E-05 2.83E-05 None 0 0 None 0 None 0 0 0
R/K 23098 Fn3-55 59 rs771768640 0.1142 -0.125 0.987 N 0.56 0.297 0.223146558224 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
R/K 23098 Fn3-55 59 rs771768640 0.1142 -0.125 0.987 N 0.56 0.297 0.223146558224 gnomAD-4.0.0 3.71908E-06 None None None None N None 6.67824E-05 1.66767E-05 None 0 0 None 0 0 0 0 0
Q/L 23300 Fn3-57 61 None 0.2644 None 0.024 N 0.467 0.245 0.308278614506 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
T/I 23493 Fn3-58 59 None 0.18 None 0.815 N 0.516 0.336 0.385906861911 gnomAD-4.0.0 6.00161E-06 None None None None N None 0 0 None 0 0 None 0 0 6.56251E-06 0 0
T/S 23493 Fn3-58 59 rs375675901 0.0744 None 0.004 N 0.188 0.093 None gnomAD-3.1.2 2.63E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
T/S 23493 Fn3-58 59 rs375675901 0.0744 None 0.004 N 0.188 0.093 None gnomAD-4.0.0 7.43708E-06 None None None None N None 6.67485E-05 0 None 0 0 None 0 0 5.08613E-06 0 1.60128E-05
E/K 23589 Fn3-59 58 None 0.4023 None 0.88 N 0.533 0.332 0.254761474806 gnomAD-4.0.0 1.59176E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85899E-06 0 0
E/Q 23589 Fn3-59 58 rs776167958 0.2042 -0.666 0.914 N 0.588 0.247 0.286848849266 gnomAD-2.1.1 8.05E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
E/Q 23589 Fn3-59 58 rs776167958 0.2042 -0.666 0.914 N 0.588 0.247 0.286848849266 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/Q 23589 Fn3-59 58 rs776167958 0.2042 -0.666 0.914 N 0.588 0.247 0.286848849266 gnomAD-4.0.0 6.57177E-06 None None None None I None 0 0 None 0 0 None 0 0 1.4705E-05 0 0
T/A 23785 Fn3-60 60 rs765937279 0.1017 -0.916 0.999 N 0.527 0.327 0.371344866733 gnomAD-2.1.1 8.1E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.79E-05 0
T/A 23785 Fn3-60 60 rs765937279 0.1017 -0.916 0.999 N 0.527 0.327 0.371344866733 gnomAD-4.0.0 6.38048E-06 None None None None N None 0 0 None 0 0 None 0 0 1.14609E-05 0 0
T/I 23785 Fn3-60 60 None 0.1947 None 1.0 N 0.769 0.389 0.466571191598 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
E/G 23983 Fn3-62 60 rs1299777918 0.2365 None 0.642 N 0.505 0.211 0.318828661733 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.41E-05 0 0
E/G 23983 Fn3-62 60 rs1299777918 0.2365 None 0.642 N 0.505 0.211 0.318828661733 gnomAD-4.0.0 6.40763E-06 None None None None N None 0 0 None 0 0 None 0 0 1.19693E-05 0 0
E/K 23983 Fn3-62 60 None 0.1667 None 0.27 N 0.367 0.24 0.201204373187 gnomAD-4.0.0 1.36864E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79913E-06 0 0
S/L 24383 Fn3-65 61 rs368415251 0.1424 0.436 0.98 N 0.596 0.321 None gnomAD-2.1.1 1.79E-05 None None None None I None 1.65659E-04 0 None 0 0 None 0 None 0 7.85E-06 0
S/L 24383 Fn3-65 61 rs368415251 0.1424 0.436 0.98 N 0.596 0.321 None gnomAD-3.1.2 3.95E-05 None None None None I None 1.44788E-04 0 0 0 0 None 0 0 0 0 0
S/L 24383 Fn3-65 61 rs368415251 0.1424 0.436 0.98 N 0.596 0.321 None gnomAD-4.0.0 7.4395E-06 None None None None I None 1.3354E-04 0 None 0 0 None 0 0 1.69562E-06 0 0
E/K 24673 Fn3-67 58 rs745794676 0.1612 0.434 0.994 N 0.532 0.348 0.31501682445 gnomAD-4.0.0 1.59302E-06 None None None None N None 0 0 None 0 0 None 1.88772E-05 0 0 0 0
T/R 24867 Fn3-68 60 None 0.3614 None 0.988 D 0.723 0.353 0.625243557465 gnomAD-4.0.0 1.203E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31565E-06 0 0
K/T 24967 Fn3-69 60 None 0.0965 None 0.051 N 0.421 0.184 0.1749357433 gnomAD-4.0.0 1.59177E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85925E-06 0 0
H/N 25065 Fn3-70 60 rs1318351282 0.0781 -0.356 0.006 N 0.225 0.093 0.168933306366 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14758E-04 0 None 0 0 None 0 None 0 0 0
H/P 25065 Fn3-70 60 rs182161195 0.6906 0.215 0.028 N 0.35 0.254 0.366848117066 gnomAD-2.1.1 3.19E-05 None None None None I None 1.14784E-04 0 None 0 0 None 0 None 0 0 0
H/R 25065 Fn3-70 60 rs182161195 0.0697 -0.626 0.003 N 0.238 0.143 None gnomAD-2.1.1 2.64306E-04 None None None None I None 0 0 None 0 3.6942E-03 None 0 None 0 7.82E-06 1.40568E-04
H/R 25065 Fn3-70 60 rs182161195 0.0697 -0.626 0.003 N 0.238 0.143 None gnomAD-3.1.2 1.18371E-04 None None None None I None 0 0 0 0 3.48972E-03 None 0 0 0 0 0
H/R 25065 Fn3-70 60 rs182161195 0.0697 -0.626 0.003 N 0.238 0.143 None 1000 genomes 5.99042E-04 None None None None I None 0 0 None None 3E-03 0 None None None 0 None
H/R 25065 Fn3-70 60 rs182161195 0.0697 -0.626 0.003 N 0.238 0.143 None gnomAD-4.0.0 2.07622E-04 None None None None I None 0 1.66639E-05 None 0 7.31588E-03 None 0 0 3.39106E-06 0 3.20215E-05
R/C 25363 Fn3-72 60 rs757511354 0.5396 -0.664 1.0 N 0.706 0.43 0.684613241775 gnomAD-2.1.1 1.21E-05 None None None None I None 6.46E-05 0 None 0 0 None 6.54E-05 None 0 0 0
R/C 25363 Fn3-72 60 rs757511354 0.5396 -0.664 1.0 N 0.706 0.43 0.684613241775 gnomAD-3.1.2 1.32E-05 None None None None I None 2.42E-05 0 0 0 1.94099E-04 None 0 0 0 0 0
R/C 25363 Fn3-72 60 rs757511354 0.5396 -0.664 1.0 N 0.706 0.43 0.684613241775 gnomAD-4.0.0 2.85157E-05 None None None None I None 2.67251E-05 0 None 0 2.45711E-04 None 0 1.64636E-04 2.28894E-05 3.29453E-05 3.20287E-05
R/H 25363 Fn3-72 60 rs749274818 0.3173 -1.065 1.0 N 0.671 0.355 0.293147016451 gnomAD-2.1.1 2.51E-05 None None None None I None 8.27E-05 0 None 0 0 None 3.27E-05 None 0 3.14E-05 0
R/H 25363 Fn3-72 60 rs749274818 0.3173 -1.065 1.0 N 0.671 0.355 0.293147016451 gnomAD-3.1.2 2.63E-05 None None None None I None 4.83E-05 6.56E-05 0 0 0 None 0 0 1.47E-05 0 0
R/H 25363 Fn3-72 60 rs749274818 0.3173 -1.065 1.0 N 0.671 0.355 0.293147016451 gnomAD-4.0.0 2.54158E-05 None None None None I None 5.34259E-05 1.668E-05 None 0 0 None 0 0 2.79766E-05 2.1964E-05 1.60149E-05
R/L 25363 Fn3-72 60 None 0.8181 None 0.913 N 0.599 0.364 0.644876160298 gnomAD-4.0.0 6.84396E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99617E-07 0 0
R/S 25363 Fn3-72 60 None 0.9231 None 0.913 N 0.589 0.273 0.38342384377 gnomAD-4.0.0 1.36879E-06 None None None None I None 0 0 None 0 0 None 0 0 1.7992E-06 0 0
T/I 25949 Fn3-76 60 rs1706723806 0.2135 None 0.955 N 0.581 0.46 0.451407941134 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
T/I 25949 Fn3-76 60 rs1706723806 0.2135 None 0.955 N 0.581 0.46 0.451407941134 gnomAD-4.0.0 6.57523E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47059E-05 0 0
Q/K 26049 Fn3-77 60 rs1706572074 0.0862 None 0.003 N 0.151 0.082 0.168933306366 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/K 26049 Fn3-77 60 rs1706572074 0.0862 None 0.003 N 0.151 0.082 0.168933306366 gnomAD-4.0.0 6.57791E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47102E-05 0 0
Q/E 26147 Fn3-78 60 rs774587761 0.0941 0.316 0.001 N 0.173 0.103 0.149567049428 gnomAD-2.1.1 2.02E-05 None None None None N None 0 0 None 0 0 None 1.6387E-04 None 0 0 0
Q/E 26147 Fn3-78 60 rs774587761 0.0941 0.316 0.001 N 0.173 0.103 0.149567049428 gnomAD-4.0.0 6.85138E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.0445E-04 1.65887E-05
Q/H 26147 Fn3-78 60 rs749374532 0.1895 -0.435 0.007 N 0.309 0.089 0.12205267543 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.68E-05 0
Q/H 26147 Fn3-78 60 rs749374532 0.1895 -0.435 0.007 N 0.309 0.089 0.12205267543 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
Q/H 26147 Fn3-78 60 rs749374532 0.1895 -0.435 0.007 N 0.309 0.089 0.12205267543 gnomAD-4.0.0 6.20374E-06 None None None None N None 0 0 None 0 0 None 0 0 8.48479E-06 0 0
S/C 26345 Fn3-79 60 rs1402438452 0.0757 None 0.928 N 0.546 0.307 0.376216005999 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
S/C 26345 Fn3-79 60 rs1402438452 0.0757 None 0.928 N 0.546 0.307 0.376216005999 gnomAD-4.0.0 6.57704E-06 None None None None N None 2.41418E-05 0 None 0 0 None 0 0 0 0 0
S/F 26345 Fn3-79 60 rs1402438452 0.124 -0.595 0.627 N 0.593 0.236 0.483448007585 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
S/F 26345 Fn3-79 60 rs1402438452 0.124 -0.595 0.627 N 0.593 0.236 0.483448007585 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/F 26345 Fn3-79 60 rs1402438452 0.124 -0.595 0.627 N 0.593 0.236 0.483448007585 gnomAD-4.0.0 6.57704E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47072E-05 0 0
S/Y 26345 Fn3-79 60 None 0.1324 -0.361 0.773 N 0.571 0.293 0.507152531357 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
S/Y 26345 Fn3-79 60 None 0.1324 -0.361 0.773 N 0.571 0.293 0.507152531357 gnomAD-4.0.0 4.77535E-06 None None None None N None 0 0 None 0 0 None 0 0 8.57819E-06 0 0
R/C 26445 Fn3-80 60 rs780658084 0.6118 -0.668 1.0 N 0.777 0.384 None gnomAD-2.1.1 8.06E-06 None None None None N None 0 2.9E-05 None 0 0 None 3.27E-05 None 0 0 0
R/C 26445 Fn3-80 60 rs780658084 0.6118 -0.668 1.0 N 0.777 0.384 None gnomAD-4.0.0 7.52881E-06 None None None None N None 0 4.47327E-05 None 0 0 None 1.88416E-05 0 1.79907E-06 3.47834E-05 4.97117E-05
R/H 26445 Fn3-80 60 rs764254441 0.4146 -1.446 1.0 N 0.771 0.342 None gnomAD-2.1.1 5.01E-05 None None None None N None 8.27E-05 5.66E-05 None 0 0 None 3.27E-05 None 0 7.05E-05 0
R/H 26445 Fn3-80 60 rs764254441 0.4146 -1.446 1.0 N 0.771 0.342 None gnomAD-3.1.2 8.55E-05 None None None None N None 0 6.55E-05 0 0 1.93874E-04 None 0 0 1.61774E-04 0 0
R/H 26445 Fn3-80 60 rs764254441 0.4146 -1.446 1.0 N 0.771 0.342 None gnomAD-4.0.0 7.19055E-05 None None None None N None 4.00502E-05 5.00283E-05 None 0 8.92817E-05 None 0 1.64474E-04 8.05303E-05 6.58747E-05 6.40594E-05
R/L 26445 Fn3-80 60 None 0.8697 None 1.0 N 0.658 0.386 0.674874776785 gnomAD-4.0.0 6.84406E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99536E-07 0 0
R/S 26445 Fn3-80 60 rs780658084 0.9656 -1.025 1.0 N 0.732 0.268 0.379193981924 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
R/S 26445 Fn3-80 60 rs780658084 0.9656 -1.025 1.0 N 0.732 0.268 0.379193981924 gnomAD-4.0.0 6.84437E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99533E-07 0 0
R/Q 26547 Fn3-81 61 rs771534555 0.0922 -0.591 0.924 N 0.491 0.179 0.128392430309 gnomAD-2.1.1 3.22E-05 None None None None I None 1.6533E-04 0 None 0 0 None 3.27E-05 None 0 3.13E-05 0
R/Q 26547 Fn3-81 61 rs771534555 0.0922 -0.591 0.924 N 0.491 0.179 0.128392430309 gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
R/Q 26547 Fn3-81 61 rs771534555 0.0922 -0.591 0.924 N 0.491 0.179 0.128392430309 gnomAD-4.0.0 2.60335E-05 None None None None I None 6.67771E-05 0 None 0 2.22955E-05 None 0 0 2.37353E-05 1.09791E-05 1.12111E-04
S/G 26741 Fn3-82 59 rs750048032 0.146 -0.557 0.745 N 0.525 0.373 None gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
S/G 26741 Fn3-82 59 rs750048032 0.146 -0.557 0.745 N 0.525 0.373 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/G 26741 Fn3-82 59 rs750048032 0.146 -0.557 0.745 N 0.525 0.373 None gnomAD-4.0.0 1.54935E-05 None None None None N None 0 0 None 0 0 None 0 0 2.1192E-05 0 0
S/N 26741 Fn3-82 59 None 0.2308 None 0.001 N 0.411 0.131 0.177238962908 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.07533E-05 0
T/A 27031 Fn3-84 60 None 0.0918 None 0.63 N 0.448 0.237 0.24896430686 gnomAD-4.0.0 1.36854E-06 None None None None N None 0 0 None 0 0 None 1.87287E-05 0 8.99536E-07 0 0
T/I 27031 Fn3-84 60 rs777849777 0.3108 0.398 0.983 N 0.641 0.437 0.513394077459 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
T/I 27031 Fn3-84 60 rs777849777 0.3108 0.398 0.983 N 0.641 0.437 0.513394077459 gnomAD-4.0.0 5.47434E-06 None None None None N None 0 0 None 0 0 None 0 0 7.19635E-06 0 0
K/R 27131 Fn3-85 60 None 0.0655 None 0.005 N 0.198 0.083 0.158396225186 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 27229 Fn3-86 60 None 0.2072 None 0.309 N 0.399 0.227 0.193865811164 gnomAD-4.0.0 1.59442E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43414E-05 0
N/K 27428 Fn3-87 60 rs749118760 0.3554 0.449 0.822 N 0.405 0.147 0.188950314367 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
N/K 27428 Fn3-87 60 rs749118760 0.3554 0.449 0.822 N 0.405 0.147 0.188950314367 gnomAD-4.0.0 2.0527E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99488E-07 2.31873E-05 0
R/Q 27528 Fn3-88 60 rs765230578 0.2555 0.185 0.994 N 0.658 0.211 None gnomAD-2.1.1 1.21E-05 None None None None N None 6.46E-05 0 None 0 5.57E-05 None 0 None 0 8.88E-06 0
R/Q 27528 Fn3-88 60 rs765230578 0.2555 0.185 0.994 N 0.658 0.211 None gnomAD-3.1.2 2.63E-05 None None None None N None 2.41E-05 6.55E-05 0 0 0 None 0 0 2.94E-05 0 0
R/Q 27528 Fn3-88 60 rs765230578 0.2555 0.185 0.994 N 0.658 0.211 None gnomAD-4.0.0 1.61126E-05 None None None None N None 1.33536E-05 1.66694E-05 None 0 2.22916E-05 None 0 0 1.78002E-05 1.09786E-05 1.60128E-05
R/W 27528 Fn3-88 60 rs749852593 0.3805 -0.222 1.0 N 0.635 0.325 0.387042434762 gnomAD-2.1.1 3.22E-05 None None None None N None 0 1.15895E-04 None 0 0 None 9.8E-05 None 0 8.88E-06 0
R/W 27528 Fn3-88 60 rs749852593 0.3805 -0.222 1.0 N 0.635 0.325 0.387042434762 gnomAD-3.1.2 1.97E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 1.47E-05 0 0
R/W 27528 Fn3-88 60 rs749852593 0.3805 -0.222 1.0 N 0.635 0.325 0.387042434762 gnomAD-4.0.0 2.29299E-05 None None None None N None 4.00641E-05 6.668E-05 None 0 0 None 0 0 1.52574E-05 1.31749E-04 0
Q/E 27630 Fn3-89 61 None 0.0869 None 0.101 N 0.339 0.1 0.148003135375 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/K 27630 Fn3-89 61 None 0.0984 None 0.001 N 0.231 0.174 0.124217242631 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
Q/P 27630 Fn3-89 61 rs375607506 0.4003 -0.145 0.523 N 0.521 0.329 None gnomAD-2.1.1 1.79E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.92E-05 0
Q/P 27630 Fn3-89 61 rs375607506 0.4003 -0.145 0.523 N 0.521 0.329 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Q/P 27630 Fn3-89 61 rs375607506 0.4003 -0.145 0.523 N 0.521 0.329 None gnomAD-4.0.0 8.67611E-06 None None None None N None 0 0 None 0 0 None 0 0 1.18672E-05 0 0
T/I 27824 Fn3-90 59 None 0.1452 None 0.012 N 0.371 0.118 0.242825505644 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
S/F 28113 Fn3-92 59 rs753201539 0.3187 -0.862 0.994 N 0.733 0.454 0.65667953858 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66168E-04
S/F 28113 Fn3-92 59 rs753201539 0.3187 -0.862 0.994 N 0.733 0.454 0.65667953858 gnomAD-4.0.0 1.02644E-05 None None None None N None 0 0 None 0 0 None 0 0 1.34926E-05 0 0
S/T 28113 Fn3-92 59 None 0.0801 None 0.944 N 0.472 0.279 0.238705975628 gnomAD-4.0.0 1.59172E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.0248E-05
S/Y 28113 Fn3-92 59 rs753201539 0.3031 -0.514 0.994 N 0.733 0.44 0.657976263744 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
Y/C 28311 Fn3-94 60 None 0.0909 None 0.032 N 0.475 0.142 0.354183961838 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31251E-06 0 0
S/F 28509 Fn3-95 60 rs1575614269 0.1333 None None N 0.464 0.202 0.482574385019 gnomAD-4.0.0 1.59209E-06 None None None None N None 0 0 None 0 2.78133E-05 None 0 0 0 0 0
S/T 28509 Fn3-95 60 rs1329788185 0.0792 -0.159 0.001 N 0.254 0.119 0.168933306366 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.94E-06 0
S/T 28509 Fn3-95 60 rs1329788185 0.0792 -0.159 0.001 N 0.254 0.119 0.168933306366 gnomAD-4.0.0 1.36869E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79899E-06 0 0
R/G 28609 Fn3-96 60 None 0.8184 None 0.892 N 0.602 0.37 0.559310644637 gnomAD-4.0.0 1.59128E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85827E-06 0 0
R/K 28609 Fn3-96 60 None 0.3555 None 0.025 N 0.359 0.154 0.185906805712 gnomAD-4.0.0 6.84214E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
R/T 28609 Fn3-96 60 rs755662471 0.7235 -0.28 0.967 N 0.677 0.326 0.480574121323 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
R/T 28609 Fn3-96 60 rs755662471 0.7235 -0.28 0.967 N 0.677 0.326 0.480574121323 gnomAD-4.0.0 6.84214E-07 None None None None N None 0 2.23604E-05 None 0 0 None 0 0 0 0 0
E/K 28709 Fn3-97 59 rs562860372 0.206 0.215 0.999 N 0.608 0.392 0.337135696972 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.96E-06 0
E/K 28709 Fn3-97 59 rs562860372 0.206 0.215 0.999 N 0.608 0.392 0.337135696972 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
E/K 28709 Fn3-97 59 rs562860372 0.206 0.215 0.999 N 0.608 0.392 0.337135696972 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 1E-03 None None None 0 None
E/K 28709 Fn3-97 59 rs562860372 0.206 0.215 0.999 N 0.608 0.392 0.337135696972 gnomAD-4.0.0 6.56754E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47003E-05 0 0
E/Q 28709 Fn3-97 59 None 0.1456 None 1.0 N 0.675 0.247 0.364141725642 gnomAD-4.0.0 3.42118E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49728E-06 0 0
H/D 28999 Fn3-99 58 rs879148150 0.1536 None 0.062 N 0.409 0.259 None gnomAD-4.0.0 1.36842E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79888E-06 0 0
H/Y 28999 Fn3-99 58 rs879148150 0.0835 None 0.211 N 0.448 0.195 0.261217442401 gnomAD-4.0.0 1.36842E-06 None None None None I None 2.98721E-05 0 None 0 0 None 0 0 8.99441E-07 0 0
M/I 29196 Fn3-100 60 None 0.1684 None None N 0.098 0.051 0.313818047136 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
M/T 29196 Fn3-100 60 rs758449685 0.0622 -1.274 None N 0.161 0.098 0.159798565429 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
M/T 29196 Fn3-100 60 rs758449685 0.0622 -1.274 None N 0.161 0.098 0.159798565429 gnomAD-4.0.0 1.59104E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43295E-05 0
M/V 29196 Fn3-100 60 rs765797994 0.0577 -1.465 None N 0.085 0.059 0.279370189704 gnomAD-2.1.1 2.81E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.21E-05 0
M/V 29196 Fn3-100 60 rs765797994 0.0577 -1.465 None N 0.085 0.059 0.279370189704 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/V 29196 Fn3-100 60 rs765797994 0.0577 -1.465 None N 0.085 0.059 0.279370189704 gnomAD-4.0.0 8.05519E-06 None None None None N None 0 0 None 0 0 None 1.56177E-05 0 9.32319E-06 0 1.60097E-05
H/D 29296 Fn3-101 60 rs1304860683 0.3743 None 1.0 N 0.726 0.45 0.353336612579 gnomAD-3.1.2 6.57E-06 None None None None I None 2.41E-05 0 0 0 0 None 0 0 0 0 0
H/D 29296 Fn3-101 60 rs1304860683 0.3743 None 1.0 N 0.726 0.45 0.353336612579 gnomAD-4.0.0 3.09821E-06 None None None None I None 1.33451E-05 0 None 0 0 None 0 0 3.3902E-06 0 0
H/Y 29296 Fn3-101 60 None 0.1219 None 0.999 N 0.534 0.467 0.371903410333 gnomAD-4.0.0 6.84157E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99418E-07 0 0
I/F 29592 Fn3-103 60 None 0.1398 None 0.884 N 0.486 0.178 0.319402600006 gnomAD-4.0.0 1.36835E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79885E-06 0 0
I/L 29592 Fn3-103 60 None 0.0945 None 0.003 N 0.153 0.091 0.223847106136 gnomAD-4.0.0 6.84173E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15934E-05 0
I/V 29592 Fn3-103 60 rs1700602244 0.0711 None 0.309 N 0.389 0.069 0.332902724076 gnomAD-4.0.0 3.42087E-06 None None None None N None 0 0 None 0 1.26027E-04 None 0 0 0 0 0
R/K 29692 Fn3-104 60 rs745523889 0.3246 -0.685 0.997 N 0.489 0.243 0.259272394797 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.89E-06 0
R/K 29692 Fn3-104 60 rs745523889 0.3246 -0.685 0.997 N 0.489 0.243 0.259272394797 gnomAD-4.0.0 6.1581E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69835E-06 6.95604E-05 0
E/D 29794 Fn3-105 61 rs1700216447 0.3485 None 0.999 N 0.507 0.229 0.188950314367 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
S/F 29991 Fn3-106 59 rs879239139 0.2034 -0.702 0.879 N 0.697 0.428 None gnomAD-2.1.1 3.19E-05 None None None None I None 1.14837E-04 0 None 0 0 None 0 None 0 0 0
S/F 29991 Fn3-106 59 rs879239139 0.2034 -0.702 0.879 N 0.697 0.428 None gnomAD-3.1.2 1.32E-05 None None None None I None 4.83E-05 0 0 0 0 None 0 0 0 0 0
S/F 29991 Fn3-106 59 rs879239139 0.2034 -0.702 0.879 N 0.697 0.428 None gnomAD-4.0.0 5.12535E-06 None None None None I None 6.76865E-05 0 None 0 0 None 0 0 0 0 0
S/T 29991 Fn3-106 59 rs777975852 0.0655 -0.014 None N 0.213 0.121 0.0551355673512 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.9E-06 0
S/T 29991 Fn3-106 59 rs777975852 0.0655 -0.014 None N 0.213 0.121 0.0551355673512 gnomAD-4.0.0 1.5914E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85796E-06 0 0
T/N 30283 Fn3-108 60 rs1385680700 0.2034 None 1.0 D 0.723 0.28 0.408444019923 gnomAD-4.0.0 1.59155E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85863E-06 0 0
E/Q 30383 Fn3-109 60 rs749647536 0.208 -0.194 1.0 N 0.671 0.241 0.372087925617 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
E/Q 30383 Fn3-109 60 rs749647536 0.208 -0.194 1.0 N 0.671 0.241 0.372087925617 gnomAD-4.0.0 1.3684E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79893E-06 0 0
Q/H 30480 Fn3-110 59 rs794729532 0.29 -0.845 0.999 N 0.669 0.32 0.277730125212 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.91E-05 None 0 0 None 0 None 0 0 0
Q/H 30480 Fn3-110 59 rs794729532 0.29 -0.845 0.999 N 0.669 0.32 0.277730125212 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
Q/H 30480 Fn3-110 59 rs794729532 0.29 -0.845 0.999 N 0.669 0.32 0.277730125212 gnomAD-4.0.0 2.47947E-06 None None None None N None 1.3354E-05 3.33611E-05 None 0 0 None 0 0 0 0 1.60169E-05
S/N 30678 Fn3-111 60 None 0.1725 None 0.822 N 0.547 0.179 0.151104730317 gnomAD-4.0.0 1.59134E-06 None None None None N None 0 0 None 0 0 None 0 0 0 0 3.02407E-05
R/T 30779 Fn3-112 61 rs1289817129 0.5109 None 1.0 N 0.709 0.341 0.520640030592 gnomAD-4.0.0 3.18207E-06 None None None None N None 0 0 None 0 5.5457E-05 None 0 0 0 0 0
Q/H 31367 Fn3-116 60 None 0.2072 None 0.996 N 0.469 0.201 0.204665344411 gnomAD-4.0.0 6.84259E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99489E-07 0 0
F/L 31568 Fn3-118 63 rs1431320981 0.6801 -0.905 0.201 N 0.416 0.147 0.273938319068 gnomAD-2.1.1 7.15E-06 None None None None N None 0 0 None 0 1.02533E-04 None 0 None 0 0 0
F/L 31568 Fn3-118 63 rs1431320981 0.6801 -0.905 0.201 N 0.416 0.147 0.273938319068 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 1.92678E-04 None 0 0 0 2.07211E-04 0
F/L 31568 Fn3-118 63 rs1431320981 0.6801 -0.905 0.201 N 0.416 0.147 0.273938319068 gnomAD-4.0.0 3.84329E-06 None None None None N None 0 0 None 0 4.84801E-05 None 0 0 0 1.34009E-05 0
S/F 31766 Fn3-119 59 rs191484894 0.3409 -0.632 1.0 N 0.863 0.466 None gnomAD-2.1.1 3.38793E-03 None None None None N None 2.0656E-04 7.63877E-04 None 1.06465E-03 1.02554E-04 None 2.16979E-02 None 4E-05 1.70344E-03 2.94695E-03
S/F 31766 Fn3-119 59 rs191484894 0.3409 -0.632 1.0 N 0.863 0.466 None gnomAD-3.1.2 1.77438E-03 None None None None N None 2.41266E-04 1.83414E-03 0 8.64055E-04 0 None 0 0 1.66093E-03 2.3198E-02 1.91388E-03
S/F 31766 Fn3-119 59 rs191484894 0.3409 -0.632 1.0 N 0.863 0.466 None 1000 genomes 5.99042E-03 None None None None N None 0 1.4E-03 None None 0 2E-03 None None None 2.76E-02 None
S/F 31766 Fn3-119 59 rs191484894 0.3409 -0.632 1.0 N 0.863 0.466 None gnomAD-4.0.0 2.17057E-03 None None None None N None 3.19838E-04 9.83301E-04 None 8.44538E-04 1.56048E-04 None 6.24785E-05 4.12405E-03 1.05695E-03 2.11787E-02 2.92903E-03
R/G 31867 Fn3-120 61 rs778708400 0.7693 None 1.0 N 0.649 0.498 0.588622743037 gnomAD-4.0.0 3.42136E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49783E-06 0 0
R/S 31867 Fn3-120 61 None 0.8203 None 1.0 N 0.708 0.31 0.305086939656 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
L/F 32163 Fn3-122 59 rs1448896859 0.093 -1.234 0.046 N 0.451 0.109 0.408853032482 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
L/F 32163 Fn3-122 59 rs1448896859 0.093 -1.234 0.046 N 0.451 0.109 0.408853032482 gnomAD-4.0.0 1.59147E-06 None None None None N None 5.65547E-05 0 None 0 0 None 0 0 0 0 0
E/G 32261 Fn3-123 60 rs1060500578 0.2132 None 0.77 N 0.495 0.335 0.352693368174 gnomAD-3.1.2 6.57E-06 None None None None N None 0 6.55E-05 0 0 0 None 0 0 0 0 0
E/G 32261 Fn3-123 60 rs1060500578 0.2132 None 0.77 N 0.495 0.335 0.352693368174 gnomAD-4.0.0 4.05999E-06 None None None None N None 0 6.15612E-05 None 0 0 None 0 0 3.61483E-06 0 0
T/A 32458 Fn3-124 60 rs1362121048 0.0909 -0.725 0.625 D 0.383 0.171 0.269111216191 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
T/A 32458 Fn3-124 60 rs1362121048 0.0909 -0.725 0.625 D 0.383 0.171 0.269111216191 gnomAD-4.0.0 1.59154E-06 None None None None N None 0 0 None 0 2.77639E-05 None 0 0 0 0 0
T/K 32458 Fn3-124 60 None 0.2737 None 0.954 N 0.507 0.346 0.332902724076 gnomAD-4.0.0 1.36853E-06 None None None None N None 2.98846E-05 0 None 0 0 None 0 0 0 0 1.65678E-05
T/M 32458 Fn3-124 60 rs749501290 0.0878 -0.033 0.672 N 0.361 0.214 0.331876078066 gnomAD-2.1.1 7.15E-06 None None None None N None 4.14E-05 2.83E-05 None 0 0 None 0 None 0 0 0
T/M 32458 Fn3-124 60 rs749501290 0.0878 -0.033 0.672 N 0.361 0.214 0.331876078066 gnomAD-3.1.2 6.58E-06 None None None None N None 2.42E-05 0 0 0 0 None 0 0 0 0 0
T/M 32458 Fn3-124 60 rs749501290 0.0878 -0.033 0.672 N 0.361 0.214 0.331876078066 gnomAD-4.0.0 1.85934E-06 None None None None N None 1.33568E-05 1.66711E-05 None 0 0 None 0 0 0 0 1.60133E-05
R/Q 32558 Fn3-125 60 rs369237346 0.1524 0.285 1.0 N 0.747 0.361 None gnomAD-2.1.1 1.07667E-04 None None None None I None 0 1.13662E-04 None 0 0 None 3.63733E-04 None 0 1.0983E-04 1.40964E-04
R/Q 32558 Fn3-125 60 rs369237346 0.1524 0.285 1.0 N 0.747 0.361 None gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 2.07039E-04 0
R/Q 32558 Fn3-125 60 rs369237346 0.1524 0.285 1.0 N 0.747 0.361 None gnomAD-4.0.0 1.22169E-04 None None None None I None 1.33568E-05 6.67579E-05 None 0 2.23284E-05 None 0 1.64582E-04 1.26345E-04 4.07633E-04 6.41026E-05
R/W 32558 Fn3-125 60 rs727505090 0.3109 -0.162 1.0 N 0.762 0.473 0.546607571196 gnomAD-2.1.1 8.08E-06 None None None None I None 0 0 None 0 0 None 0 None 0 1.78E-05 0
R/W 32558 Fn3-125 60 rs727505090 0.3109 -0.162 1.0 N 0.762 0.473 0.546607571196 gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
R/W 32558 Fn3-125 60 rs727505090 0.3109 -0.162 1.0 N 0.762 0.473 0.546607571196 gnomAD-4.0.0 4.96078E-06 None None None None I None 1.33533E-05 3.337E-05 None 0 0 None 0 0 4.23968E-06 0 0
E/K 32659 Fn3-126 60 None 0.7746 None 0.999 N 0.569 0.414 0.378847511475 gnomAD-4.0.0 3.18234E-06 None None None None N None 0 0 None 0 0 None 1.88232E-05 0 2.85824E-06 0 0
E/Q 32659 Fn3-126 60 None 0.3952 None 1.0 N 0.648 0.311 0.264547087235 gnomAD-4.0.0 1.59117E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85824E-06 0 0
E/V 32659 Fn3-126 60 rs747898161 0.7657 0.386 1.0 N 0.757 0.558 0.623669286631 gnomAD-2.1.1 8.03E-06 None None None None N None 1.29182E-04 0 None 0 0 None 0 None 0 0 0
E/V 32659 Fn3-126 60 rs747898161 0.7657 0.386 1.0 N 0.757 0.558 0.623669286631 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
E/V 32659 Fn3-126 60 rs747898161 0.7657 0.386 1.0 N 0.757 0.558 0.623669286631 gnomAD-4.0.0 3.84307E-06 None None None None N None 5.07477E-05 0 None 0 0 None 0 0 0 0 0
S/F 32854 Fn3-127 60 rs958621500 0.447 -0.725 0.999 N 0.797 0.423 0.718403584121 gnomAD-2.1.1 1.21E-05 None None None None N None 0 8.69E-05 None 0 0 None 0 None 0 0 0
S/F 32854 Fn3-127 60 rs958621500 0.447 -0.725 0.999 N 0.797 0.423 0.718403584121 gnomAD-3.1.2 3.29E-05 None None None None N None 0 3.27611E-04 0 0 0 None 0 0 0 0 0
S/F 32854 Fn3-127 60 rs958621500 0.447 -0.725 0.999 N 0.797 0.423 0.718403584121 gnomAD-4.0.0 6.19697E-06 None None None None N None 0 1.33369E-04 None 0 0 None 0 0 1.69521E-06 0 0
S/T 32854 Fn3-127 60 None 0.1398 None 0.989 N 0.434 0.286 0.185906805712 gnomAD-4.0.0 2.05259E-06 None None None None N None 0 0 None 0 2.51927E-05 None 0 0 1.79895E-06 0 0
S/Y 32854 Fn3-127 60 None 0.3978 None 0.999 N 0.797 0.423 0.707523986535 gnomAD-4.0.0 6.84198E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99473E-07 0 0
M/K 32956 Fn3-128 61 None 0.5093 None 0.994 N 0.659 0.457 0.638638447811 gnomAD-4.0.0 6.8422E-07 None None None None N None 0 0 None 0 0 None 0 0 0 0 1.65662E-05
M/R 32956 Fn3-128 61 None 0.51 None 0.998 N 0.696 0.48 0.622465732353 gnomAD-4.0.0 1.36844E-06 None None None None N None 0 0 None 0 0 None 0 0 1.799E-06 0 0
M/T 32956 Fn3-128 61 rs727504962 0.2881 None 0.994 N 0.641 0.455 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
M/T 32956 Fn3-128 61 rs727504962 0.2881 None 0.994 N 0.641 0.455 None gnomAD-4.0.0 9.2957E-06 None None None None N None 1.33501E-05 0 None 0 0 None 0 0 1.18671E-05 0 0
M/V 32956 Fn3-128 61 rs727503538 0.1449 -0.144 0.985 N 0.509 0.344 0.526539220858 gnomAD-2.1.1 1.43E-05 None None None None N None 8.26E-05 0 None 0 1.02459E-04 None 0 None 0 0 0
M/V 32956 Fn3-128 61 rs727503538 0.1449 -0.144 0.985 N 0.509 0.344 0.526539220858 gnomAD-3.1.2 3.94E-05 None None None None N None 7.24E-05 1.31096E-04 0 0 0 None 0 0 0 0 4.78011E-04
M/V 32956 Fn3-128 61 rs727503538 0.1449 -0.144 0.985 N 0.509 0.344 0.526539220858 gnomAD-4.0.0 1.85901E-05 None None None None N None 7.99659E-05 3.33378E-05 None 0 1.11448E-04 None 0 0 8.47659E-07 0 2.56082E-04
Q/H 33057 Fn3-129 60 None 0.2221 None 0.999 N 0.667 0.323 0.215869574891 gnomAD-4.0.0 1.36844E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79899E-06 0 0
Q/K 33057 Fn3-129 60 rs756651625 0.1235 0.04 0.997 N 0.473 0.344 0.262175524916 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
Q/K 33057 Fn3-129 60 rs756651625 0.1235 0.04 0.997 N 0.473 0.344 0.262175524916 gnomAD-4.0.0 7.95661E-06 None None None None N None 0 0 None 0 0 None 0 0 0 7.16394E-05 0
Q/P 33057 Fn3-129 60 rs1177530238 0.6876 0.155 0.999 N 0.697 0.535 0.488337271218 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.87E-06 0
Q/P 33057 Fn3-129 60 rs1177530238 0.6876 0.155 0.999 N 0.697 0.535 0.488337271218 gnomAD-4.0.0 3.18261E-06 None None None None N None 0 2.28624E-05 None 0 0 None 0 0 2.85851E-06 0 0
T/I 33350 Fn3-130 61 rs370300135 0.5047 0.301 0.946 N 0.754 0.379 None gnomAD-2.1.1 1.25489E-04 None None None None N None 2.90939E-04 0 None 0 1.3929E-03 None 0 None 0 0 1.40885E-04
T/I 33350 Fn3-130 61 rs370300135 0.5047 0.301 0.946 N 0.754 0.379 None gnomAD-3.1.2 1.64292E-04 None None None None N None 3.86194E-04 0 0 0 1.7341E-03 None 0 0 0 0 0
T/I 33350 Fn3-130 61 rs370300135 0.5047 0.301 0.946 N 0.754 0.379 None 1000 genomes 5.99042E-04 None None None None N None 0 0 None None 3E-03 0 None None None 0 None
T/I 33350 Fn3-130 61 rs370300135 0.5047 0.301 0.946 N 0.754 0.379 None gnomAD-4.0.0 4.52519E-05 None None None None N None 2.66667E-04 0 None 0 8.7038E-04 None 0 0 2.54334E-06 1.09926E-05 1.60133E-04
V/A 33451 Fn3-131 60 rs1467511236 0.217 -1.143 0.911 N 0.413 0.092 0.515430650102 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.89E-06 0
V/L 33451 Fn3-131 60 rs2154137428 0.274 None 0.977 N 0.464 0.203 0.498323335527 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 3.16456E-03 0 0 0
V/L 33451 Fn3-131 60 rs2154137428 0.274 None 0.977 N 0.464 0.203 0.498323335527 gnomAD-4.0.0 6.56564E-06 None None None None I None 0 0 None 0 0 None 0 3.40136E-03 0 0 0
R/C 33746 Fn3-132 58 rs199594729 0.186 -0.478 1.0 N 0.532 0.358 0.667503297862 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 1.77E-05 0
R/C 33746 Fn3-132 58 rs199594729 0.186 -0.478 1.0 N 0.532 0.358 0.667503297862 gnomAD-3.1.2 3.29E-05 None None None None N None 0 1.96412E-04 0 0 0 None 0 0 2.94E-05 0 0
R/C 33746 Fn3-132 58 rs199594729 0.186 -0.478 1.0 N 0.532 0.358 0.667503297862 gnomAD-4.0.0 9.91489E-06 None None None None N None 2.67008E-05 5.00033E-05 None 0 4.45494E-05 None 0 0 4.23786E-06 1.09786E-05 4.80261E-05
R/H 33746 Fn3-132 58 rs372584865 0.1017 -1.193 0.067 N 0.345 0.203 None gnomAD-2.1.1 1.61E-05 None None None None N None 0 2.9E-05 None 0 0 None 3.27E-05 None 0 1.77E-05 0
R/H 33746 Fn3-132 58 rs372584865 0.1017 -1.193 0.067 N 0.345 0.203 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/H 33746 Fn3-132 58 rs372584865 0.1017 -1.193 0.067 N 0.345 0.203 None gnomAD-4.0.0 1.61112E-05 None None None None N None 1.33522E-05 1.66672E-05 None 0 0 None 0 0 1.69512E-05 2.19553E-05 3.20184E-05
R/P 33746 Fn3-132 58 rs372584865 0.9482 None 0.994 N 0.555 0.331 0.50466331119 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
R/P 33746 Fn3-132 58 rs372584865 0.9482 None 0.994 N 0.555 0.331 0.50466331119 gnomAD-4.0.0 2.47865E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39024E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.